TumAuto Cancer Research Results

TumAuto, Tumor autophagy: Click to Expand ⟱

Source: HalifaxProj(activate)

Type:

Autophagy genes, including Atg3, Atg5, Atg6, Atg7, Atg10, Atg12, and Atg17.
Tumor autophagy refers to the process by which cancer cells degrade and recycle cellular components through autophagy, a cellular mechanism that helps maintain homeostasis and respond to stress. Autophagy can have dual roles in cancer, acting as both a tumor suppressor and a promoter, depending on the context.
Authophagy is the process used by cancer cells to “self-eat” to survive. Authophagy can be both good and bad. If authophagy is prolonged this will become a lethal process to cancer. On the other hand, for a short while (e.g. during chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive.
For example, Chloroquine is a blocker of autophagy and has been used in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy.

Scientific Papers found: Click to Expand⟱

4894-

Sper,

Application of Spermidine in Cancer Research Models: Notes and Protocols

-

Review,

Var,

NA

TumAuto↑, AntiTum↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑,

4895-

Sper,

Spermidine as a target for cancer therapy

-

Review,

Var,

NA

-

Review,

AD,

NA

TumAuto↑, Apoptosis↑, OS↑, CRM↑, TumCG⇅, cardioP↑, cognitive↑, *Dose⇅,

4897-

Sper,

Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms

-

Review,

Var,

NA

Inflam↓, TumAuto↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Bcl-2↓,

1018-

SSE,

Selenite-induced autophagy antagonizes apoptosis in colorectal cancer cells in vitro and in vivo

-

vitro+vivo,

CRC,

HCT116

injected i.p. with sodium selenite (2 mg/kg/day

-

vitro+vivo,

CRC,

SW480

TumAuto↑, LC3s↑, TumW↓, Weight∅, Beclin-1/ATG6↑, p62↓, ROS↑,

5074-

SSE,

Application of Sodium Selenite in the Prevention and Treatment of Cancers

-

Review,

Var,

NA

Imm↑, angioG↑, DNArepair↑, NK cell↑, ROS↑, AntiCan↑, selectivity↑, ER Stress↑, TumAuto↑, necrosis↑, toxicity↝, Dose↑,

5110-

SSE,

Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells

-

in-vitro,

AML,

APL NB4

Apoptosis↑, selectivity↑, TumAuto↓, PI3K↓, Akt↓,

5105-

SSE,

Sodium selenite induces apoptosis by generation of superoxide via the mitochondrial-dependent pathway in human prostate cancer cells

-

in-vitro,

Pca,

LNCaP

0, 0.5, 1.0, 1.5, 2.0, or 2.5 μM selenite for 5 days

TumCD↑, Apoptosis↑, ROS↑, eff↓, MMP↓, Cyt‑c↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, necrosis↑, chemoPv↑,

5086-

SSE,

Sodium Selenite Induces Superoxide-Mediated Mitochondrial Damage and Subsequent Autophagic Cell Death in Malignant Glioma Cells

-

in-vitro,

GBM,

U87MG

-

in-vitro,

GBM,

T98G

-

in-vitro,

GBM,

A172

TumAuto↑, ROS↑, TumCD↑, tumCV↓, selectivity↑, MMP↓, eff↓, MitoP↑,

2350-

UA,

Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells

-

in-vitro,

BC,

MCF7

20uM

-

in-vitro,

BC,

MDA-MB-231

Akt↓, Glycolysis↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, AMPK↑, TumAuto↑, Apoptosis↑, ERK↓, MMP↓, NO↑, ROS↑, DNAdam↑,

5021-

UA,

Anticancer effect of ursolic acid via mitochondria-dependent pathways

-

Review,

Var,

NA

Inflam↓, TNF-α↓, IL6↓, IL17↓, NF-kB↓, COX2/PTGS2↓, *AntiDiabetic↑, *hepatoP↑, ALAT↓, AST↓, TumCP↓, Apoptosis↑, TumCCA↑, TumAuto↑, tumCV↓, TumCMig↓, Glycolysis↓, ATP↓, lactateProd↓, HK2↓, PKA↓, COX2/PTGS2↓, mtDam↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, ROS↑, MMP↓, P53↑,

4833-

Uro,

Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine

-

Review,

Var,

NA

392 to 566 µM across various breast cancer cell lines

-

Review,

AD,

NA

-

Review,

IBD,

NA

BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2/PTGS2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,

4837-

Uro,

Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review

-

Review,

Var,

NA

AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2/PTGS2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,

4847-

Uro,

Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells

-

in-vitro,

CRC,

SW-620

TumCP↓, TumCMig↓, MMP9↓, TumAuto↑, Apoptosis↑, TumCCA↓, TumMeta↓, ChemoSen↓,

4849-

Uro,

Urolithin A suppresses tumor progression and induces autophagy in gastric cancer via the PI3K/Akt/mTOR pathway

-

vitro+vivo,

GC,

NA

TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, TumAuto↑, TumCG↓, chemoP↑, ChemoSen↑,

1824-

VitK2,

Vitamin K and its analogs: Potential avenues for prostate cancer management

-

Review,

Pca,

NA

AntiCan↑, toxicity∅, Risk↓, Apoptosis↑, ROS↑, TumCCA↑, Synergy↑, DNAdam↑, MMP↓, Cyt‑c↑, pro‑Casp3↑, FasL↑, Fas↑, TumAuto↑, ChemoSen↑, RadioS↑,

1817-

VitK2,

Research progress on the anticancer effects of vitamin K2

-

Review,

Var,

NA

TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, Synergy↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27/CDKN1B↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, Synergy↑, Synergy↑,

1816-

VitK2,

Role of Vitamin K in Selected Malignant Neoplasms in Women

-

Review,

Var,

NA

TumCP↓, TumMeta↓, TumAuto↑, Apoptosis↑, Apoptosis↑, Casp3↑, Casp7↑, ROS↑, AR↓, EMT↓, Wnt↓, MMP↓, Cyt‑c↑, NF-kB↓, cycD1/CCND1↓, TumCCA↓,

1214-

VitK2,

Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells

-

in-vitro,

Bladder,

T24/HTB-9

50 μM

-

in-vitro,

Bladder,

J82

Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,

1837-

VitK3,

VitC,

Alpha-Tocopheryl Succinate Inhibits Autophagic Survival of Prostate Cancer Cells Induced by Vitamin K3 and Ascorbate to Trigger Cell Death

-

in-vivo,

Pca,

NA

mice

eff↑, ROS↑, TumAuto↑,

9133-

ZYF,

Zyflamend induces apoptosis in pancreatic cancer cells via modulation of the JNK pathway

-

in-vitro,

PC,

NA

TumCP↓, Apoptosis↑, TumCCA↑, ER Stress↑, TumAuto↑, JNK↑, Synergy↑, cl‑Casp3↑, cl‑PARP↑, p‑Akt↓, ERK↓, PERK↑, eIF2α↑, p‑IRE1↑, CHOP/DDIT3↑, AMPK↑,

Showing Research Papers: 301 to 320 of 320
Prev Page 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 320

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4, ARE↓, 1, Catalase↓, 4, Catalase↑, 5, DJ-1↓, 1, Fenton↑, 3, GPx↓, 1, GPx4↓, 10, GPx4↑, 1, GSH↓, 14, GSH↑, 2, GSH/GSSG↓, 1, GSR↑, 1, GSTs↑, 2, H2O2↑, 8, HNE↑, 1, HO-1↓, 6, HO-1↑, 3, Iron↑, 9, i-Iron↓, 1, i-Iron↑, 2, Keap1↑, 1, Keap1↝, 1, lipid-P↓, 2, lipid-P↑, 7, MDA↓, 2, MDA↑, 5, NQO1↓, 1, NQO1↑, 1, NRF2↓, 9, NRF2↑, 4, NRF2↝, 1, Prx↓, 2, PrxI↓, 1, PrxII↓, 1, ROS↓, 14, ROS↑, 169, ROS⇅, 2, ROS↝, 2, i-ROS↑, 1, m-ROS↑, 1, mt-ROS↑, 4, SOD?, 1, SOD↓, 3, SOD↑, 2, mt-SOD↑, 1, SOD1↓, 1, SOD2↓, 1, SOD2↑, 1, TAC↓, 1, Thiols↓, 1, TKT↓, 1, TrxR↓, 2, TrxR1↓, 3, xCT/SLC7A11↓, 4, xCT/SLC7A11↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 6, FTH1↓, 1, IronCh↑, 1, NCOA4↑, 1, SFXN2↓, 1, Tf↓, 1, Tf↑, 2, TfR1/CD71↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1, CDC2↓, 4, CDC25↓, 8, compI↓, 4, compIII↓, 1, compV↓, 1, EGF↓, 1, ETC↓, 3, Insulin↓, 1, mitResp↓, 2, mitResp↑, 1, Mortalin↓, 1, mtDam↑, 27, OCR↓, 6, OCR↑, 1, OXPHOS↓, 6, OXPHOS↑, 5, OXPHOS↝, 1, mt-OXPHOS↓, 1, PDH↓, 2, PDH↝, 1, PINK1↑, 5, SIRT3↑, 2,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1, AApath↓, 1, ACC↓, 1, ACC-α↓, 1, ACC1↓, 1, Acetyl-CoA↓, 1, ACLY↓, 4, ACSL4↑, 1, ALAT↓, 2, ALDOA↓, 1, AMP↓, 1, AMP↑, 1, AMPK↑, 26, p‑AMPK↑, 2, ATGL/PNPLA2↓, 1, ATP↓, 26, ATP↝, 1, CRM↑, 2, ECAR↓, 1, ENO1↓, 1, FASN↓, 2, FFA/NEFA↓, 1, GAPDH↓, 1, GLS↑, 1, glucose↓, 2, GlucoseCon↓, 4, GlucoseCon↑, 1, GlutMet↑, 1, Glycolysis↓, 25, Glycolysis↑, 1, Glycolysis↝, 1, GSK‐3β↓, 5, GSK‐3β↑, 2, p‑GSK‐3β↓, 1, Histones↝, 1, HK1↓, 1, HK2↓, 15, HK2↑, 1, HMG-CoA↓, 3, HSL/LIPE↓, 1, p‑HSL/LIPE↑, 1, lactateProd↓, 12, lactateProd↑, 1, LDHA↓, 4, LDHA↑, 1, LDL↓, 1, lipoGen↓, 2, MCT4↓, 1, NAD↑, 1, NADH:NAD↓, 1, NADPH↓, 1, PDK1 / PDPK1↓, 3, p‑PDK1 / PDPK1↓, 1, PDKs↓, 1, PFK↓, 1, PFKP↓, 1, PKM2↓, 10, PKM2↑, 1, PLA2↓, 1, p‑S6↓, 1, SCP2↓, 1, SIRT1↓, 5, SIRT1↑, 4, SREBP1/SREBF1↓, 2, TCA↓, 2, Warburg↓, 3,

Cell Death(tgid=5) ⓘ

AIF↑, 5, APAF1↑, 4, Apoptosis?, 2, Apoptosis↓, 4, Apoptosis↑, 183, mt-Apoptosis↑, 1, ASC↓, 1, BAD↓, 1, BAD↑, 5, Bak↑, 1, BAX↓, 1, BAX↑, 50, Bax:Bcl2↑, 15, Bcl-2↓, 57, Bcl-2↑, 1, Bcl-xL↓, 12, Bcl-xL↑, 2, BID↑, 2, cl‑BID↑, 1, BIM↑, 2, BNIP3?, 1, BNIP3↝, 2, Casp↑, 16, cl‑Casp↑, 1, Casp1↓, 2, proCasp1↓, 1, Casp12↑, 2, Casp3↓, 2, Casp3↑, 62, cl‑Casp3↑, 29, proCasp3↓, 1, proCasp3↑, 1, pro‑Casp3↑, 1, Casp6↑, 1, Casp7↑, 3, cl‑Casp7↑, 1, Casp8↑, 14, cl‑Casp8↑, 2, proCasp8↑, 2, Casp9↑, 33, cl‑Casp9↑, 7, proCasp9↑, 1, CellShr↑, 1, cFLIP↓, 3, Cyt‑c↑, 41, DR5↑, 9, Endon↑, 1, FADD↑, 3, Fap1↓, 1, Fas?, 1, Fas↓, 2, Fas↑, 13, FasL↑, 8, Ferroptosis↓, 1, Ferroptosis↑, 20, GRP58↓, 1, IAP1↓, 4, ICD↑, 2, iNOS↓, 5, iNOS↑, 1, Mcl-1↓, 4, MDM2↓, 8, MLKL↑, 2, p‑MLKL↓, 1, MOMP↑, 5, Necroptosis↑, 4, necrosis↑, 8, NOXA↑, 1, oncosis↑, 2, P2X7↓, 1, p38↓, 4, p38↑, 11, p‑p38↑, 3, Paraptosis↑, 2, PUMA↓, 1, PUMA↑, 2, Pyro↑, 2, RIP3↓, 1, RIP3↑, 2, p‑RIP3↑, 2, survivin↓, 20, TNFR 1↑, 1, TRAIL↑, 2, TRAIL⇅, 1, TRAILR↑, 2, TumCD↓, 1, TumCD↑, 18, XIAP↓, 7, YAP/TEAD↓, 6,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 87, Akt↑, 4, p‑Akt↓, 21, p‑Akt↑, 1, AKT1↓, 3, AMPKα↑, 3, BCAP↓, 1, CaMKII ↓, 1, Cavin3↓, 1, CIP2A↓, 2, cMET↓, 1, p‑cMET↑, 1, EGFR↓, 13, ERK↓, 17, ERK↑, 3, ERK↝, 2, p‑ERK↓, 6, p‑ERK↑, 3, FOXD3↑, 1, GNAI1↓, 1, HER2/EBBR2↓, 6, Hippo↓, 1, IGFR↓, 1, IKKα↓, 1, IKKα↑, 1, p‑IKKα↓, 1, IκB↑, 1, JAK↓, 2, JAK1↓, 2, JAK2↓, 2, JAK3↓, 1, JNK↓, 3, JNK↑, 18, p‑JNK↑, 2, p‑MAP2K1/MEK1↓, 1, MAPK↓, 14, MAPK↑, 11, MAPK↝, 1, p‑MAPK↓, 1, p‑MAPK↑, 1, MEK↓, 3, MEK↑, 1, MKK4↓, 1, mTOR↓, 75, mTOR↑, 7, mTOR∅, 1, p‑mTOR↓, 13, p‑mTOR↑, 1, mTORC2↓, 2, p‑p70S6↓, 2, P70S6K↓, 6, P70S6K↑, 1, p‑P70S6K↓, 1, p‑P70S6K↑, 1, PDE3B↓, 1, PDGFR-BB↑, 1, PDGFRB↓, 1, PI3K↓, 64, PI3K↑, 1, p‑PI3K↓, 3, PI3k/Akt/mTOR↓, 2, PIK3CA↑, 1, p‑PIK3R1↓, 1, PKA↓, 1, p‑PKA↓, 1, PKCδ↓, 3, PP2A↑, 1, PRAS40↑, 1, PTEN↓, 1, PTEN↑, 7, Raf↓, 1, RAS↓, 5, Rictor↓, 1, RIP1↓, 2, SHP1↑, 1, Sp1/3/4↓, 7, Src↓, 1, STAT↓, 2, STAT3↓, 19, STAT3↑, 3, STAT3↝, 2, p‑STAT3↓, 1, STAT6↓, 1, THEM4/CTMP↑, 1, TSC2↑, 2,

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1, ATF4↑, 7, cJun↓, 1, cJun↑, 2, cMyc↓, 10, cMyc↑, 2, p‑cMyc↑, 1, COMP↓, 1, CREBBP↓, 1, DNMT1↓, 2, DNMT3A↓, 1, DNMT3B↓, 1, DNMTs↓, 1, EZH2↓, 2, FOXM1↓, 1, FOXO↓, 1, FOXO1↓, 1, FOXO1↑, 3, FOXO3↓, 2, FOXO3↑, 3, FOXO3↝, 1, FOXO4↑, 1, ac‑H3↑, 1, ac‑H4↑, 1, HATs↓, 1, HDAC↓, 8, HDAC∅, 1, HDAC3↓, 1, HDAC4↓, 1, HDAC8↓, 2, HES1↓, 1, HMTs↓, 1, JPT1/HN1↓, 1, LINC01116↓, 1, miR-107↑, 1, miR-10b-5p↓, 1, miR-133a-3p↑, 1, miR-139-5p↑, 2, miR-140↑, 1, miR-155↓, 1, miR-182-5p↓, 1, miR-199↓, 1, miR-200c↑, 1, miR-21↓, 4, miR-224↓, 1, miR-25-5p↓, 1, miR-29b↓, 1, miR-340↓, 1, miR-34a↑, 2, miR-375↑, 1, miR-384↑, 1, miR-422a↑, 1, miR-486↑, 1, miR-592↑, 1, MTA2↓, 1, Myc↓, 2, OCT4↓, 4, other?, 1, other↓, 5, other↑, 4, other↝, 17, SOX2↓, 1, SOX4↓, 2, SUV39H↓, 1, TFAP2A↓, 1, TFE3↑, 2, tumCV?, 1, tumCV↓, 41, tumCV↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2, CHOP/DDIT3↓, 2, CHOP/DDIT3↑, 19, CHOP/DDIT3↝, 1, CUL1↝, 1, CUL5↝, 1, eIF2α↓, 1, eIF2α↑, 6, p‑eIF2α↑, 2, ER Stress↓, 1, ER Stress↑, 50, Erlin1↑, 1, ERStress↑, 1, GRP78/BiP↓, 3, GRP78/BiP↑, 9, GRP94↑, 1, HSP27↓, 1, HSP70/HSPA5↓, 2, HSP90↓, 10, HSP90↑, 1, HSPs↑, 1, IRE1↓, 1, IRE1↑, 2, p‑IRE1↑, 1, PDI↑, 2, PERK↑, 7, Proteasome↓, 1, UPR↑, 6, XBP-1↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

APA↑, 1, ATG13↑, 2, ATG16L1↑, 1, ATG3↑, 5, ATG5↑, 17, ATG5↝, 1, ATG7↑, 7, autoF↓, 2, autolysosome↑, 1, AVOs↑, 1, Beclin-1/ATG6↓, 4, Beclin-1/ATG6↑, 49, Beclin-1/ATG6↝, 1, p‑Beclin-1/ATG6↑, 2, CTSB↓, 2, CTSD↓, 1, CTSL↓, 1, CTSL↑, 1, CTSS↓, 1, CTSZ↓, 1, LAMP1?, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 14, LC3A↑, 1, LC3B↑, 5, LC3B-II↓, 1, LC3B-II↑, 11, LC3I↓, 1, LC3I↑, 2, LC3II↑, 41, LC3s↓, 1, LC3s↑, 3, LC3s↝, 1, lysoM↓, 1, LysoPr↑, 1, lysosome↓, 3, MitoP↑, 3, p62↓, 28, p62↑, 11, PARK2↑, 4, RUBCN↓, 1, TFEB↑, 1, TumAuto?, 1, TumAuto↓, 16, TumAuto↑, 299, TumAuto⇅, 2, TumAuto↝, 3, mt-TumAuto↑, 2, ULK1/ATG1↑, 2,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1, p‑ATM↑, 1, p‑ATR↑, 1, BRCA1↓, 1, BRCA1↝, 1, DFF45↑, 1, DNAdam↑, 31, DNAdam⇅, 1, DNArepair↓, 1, DNArepair↑, 1, ERCC3↑, 1, m-FAM72A↓, 1, HR↓, 1, hTERT/TERT↓, 4, p16↑, 2, P53↓, 3, P53↑, 45, p‑P53↑, 4, PARP↓, 1, PARP↑, 10, p‑PARP↑, 1, cl‑PARP↑, 34, cl‑PARP↝, 1, PARP1↑, 1, cl‑PARP1↑, 2, PCNA↓, 5, RAD51↓, 1, Telomerase↓, 4, TP53↓, 1, TP53↑, 1, TRF2↓, 1, XRCC1↓, 1, γH2AX↑, 5,

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1, CDK1↓, 5, CDK1↑, 1, CDK2↓, 6, CDK2↑, 2, CDK4↓, 6, CDK4↑, 1, CDK4/6↓, 1, CDK6↓, 4, CDK6↑, 1, CDK7↓, 1, CDKN1C/p57↓, 1, p‑CHK1↑, 2, p‑Chk2↑, 1, ChrCon↑, 1, cycA1/CCNA1↓, 2, CycB/CCNB1↓, 9, CycB/CCNB1↑, 1, cycD1/CCND1↓, 18, cycD1/CCND1↑, 1, CycD3↓, 1, cycE/CCNE↓, 4, cycE1↓, 1, E2Fs↓, 2, Ki-67↓, 11, MAD↓, 1, mitA↓, 1, mitA↑, 1, P21↓, 2, P21↑, 21, p27/CDKN1B↓, 2, p27/CDKN1B↑, 8, RB1↑, 1, TumCCA↓, 3, TumCCA↑, 96, WEE1↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2, 4E-BP1↑, 1, p‑4E-BP1↓, 3, ALDH↓, 2, ALDH1A1↓, 1, BMI1↓, 3, BMP2↓, 1, BMP7/OP1↓, 1, CD133↓, 2, CD24↓, 1, cFos↓, 1, cMYB↓, 1, CSCs↓, 24, CSCs↑, 1, CSCsMark↓, 1, Diff↑, 2, EIF4E↓, 1, Gli1↓, 2, HH↓, 5, HMGCR↓, 2, IGF-1↓, 3, JAG1↓, 1, p‑Jun↑, 1, Ki-67↓, 11, Let-7↑, 1, LGR5↓, 1, mTORC1↓, 9, Nanog↓, 4, NICD↓, 1, NOTCH↓, 6, NOTCH↑, 1, NOTCH1↓, 6, NOTCH1↑, 1, NOTCH3↓, 1, Piezo1↑, 1, PTCH1↓, 1, Shh↓, 2, Smo↓, 1, STAT1↓, 1, TAZ↓, 1, TumCG?, 1, TumCG↓, 60, TumCG↑, 1, TumCG⇅, 1, TumCP?, 1, TumCP↓, 106, TumCP↑, 2, tyrosinase↓, 1, Wnt↓, 23, Wnt/(β-catenin)↓, 4, Wnt/(β-catenin)↑, 1,

Migration(tgid=13) ⓘ

AEG1↓, 1, AGRN↓, 1, annexin II↓, 1, AP-1↓, 2, AP-1↑, 1, ASAP2↓, 1, AXL↓, 1, Ca+2↓, 2, Ca+2↑, 19, CAFs/TAFs↓, 1, Cal1↑, 1, cal2↑, 1, Cav1↓, 1, CCN2/CTGF↓, 1, Chl↑, 1, COL1↓, 2, COL2A1↓, 1, COL4A3↓, 1, COL9A3↓, 1, E-cadherin↑, 14, EMT↓, 30, EMT↑, 1, EpCAM↓, 1, F-actin↓, 1, FAK↓, 5, FAK↑, 1, Fibronectin↓, 1, GLI2↓, 1, GP1BB↓, 1, ITGB1↓, 2, ITGB1↑, 1, ITGB4↓, 1, ITGB6↓, 2, LAMA5↓, 1, LRP1↓, 1, MALAT1↓, 2, MET↓, 1, MMP-10↓, 1, MMP1↓, 1, MMP13↓, 1, MMP15↓, 1, MMP16↓, 1, MMP2↓, 27, MMP3↓, 5, MMP9↓, 34, MMP9:TIMP1↓, 1, MMPs↓, 7, MTA1↓, 1, N-cadherin↓, 7, NCAM↑, 1, PAK1↓, 3, PAK1↑, 1, RECK↑, 1, Rho↓, 1, ROCK1↓, 2, Sharpin↓, 1, Slug↓, 4, Smad1↓, 1, SMAD3↓, 1, SMAD4↓, 1, p‑SMAD4↓, 1, Snail?, 1, Snail↓, 9, STAC2↓, 1, TET1↑, 2, TGF-β↓, 6, TGF-β↑, 2, TIMP1↓, 1, TIMP1↑, 5, TIMP2↓, 3, TIMP2↑, 4, TSC1↑, 1, TumCA↓, 2, TumCA↑, 1, TumCI?, 1, TumCI↓, 49, TumCMig↓, 42, TumMeta↓, 37, TumMeta↑, 1, Twist↓, 3, uPA↓, 6, uPAR↓, 1, Vim↓, 14, Zeb1↓, 3, ZEB2↓, 1, α-SMA↓, 1, ac‑α-tubulin↑, 1, β-catenin/ZEB1↓, 19,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 50, angioG↑, 2, CD31/PECAM-1↓, 2, ECM/TCF↓, 1, Endoglin↑, 1, eNOS↓, 1, eNOS↑, 1, HIF-1↓, 3, Hif1a↓, 21, Hif1a↑, 2, NO↓, 2, NO↑, 3, TYMP/ECGF1↓, 1, VCAM-1↓, 1, VEGF↓, 30, VEGFR1↓, 2, VEGFR2/KDR/Flk1↓, 8,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1, BBB∅, 1, CLDN1↓, 1, CX43/GJA1↓, 1, EPR↑, 2, GLUT1↓, 8, GLUT1↑, 1, GLUT2↓, 1, GLUT4↓, 1, MMP?, 1, MMP↓, 72, MMP↑, 1, MPT↑, 5, TRPM7↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1, CD4+↓, 1, CD4+↑, 1, CD44↓, 6, CD59↑, 1, COX2/PTGS2↓, 25, COX2/PTGS2↑, 1, CXCL6/GCP-2↓, 1, CXCR4↓, 3, DR4↑, 4, FOXP3↑, 2, Gal1↑, 1, HLA-I/II↑, 1, HMGB1↓, 2, ICAM-1↓, 2, IFN-γ↓, 2, Igs↑, 1, IL1↓, 4, IL10↓, 3, IL17↓, 1, IL1β↓, 6, IL1β↑, 1, IL2↓, 1, IL4↓, 2, IL4↑, 1, IL6↓, 13, IL8↓, 3, Imm↑, 14, Imm↝, 3, Inflam↓, 20, Inflam↝, 1, IRAK1↓, 1, LRIG1↑, 1, pol-M1↑, 1, M2 MC↓, 2, MCP1/CCL2↓, 3, MCT1↓, 1, MIP2↓, 1, MyD88↑, 1, NAF1↓, 1, NF-kB↓, 51, NF-kB↑, 3, NF-kB↝, 1, p‑NF-kB↓, 1, p‑NF-kB↑, 1, NK cell↑, 2, NLRP3↓, 2, NLRP3↑, 2, NOD1↓, 1, p65↓, 1, PD-1↓, 1, PD-L1↓, 4, PGE2↓, 7, PSA↓, 1, RAGE↓, 2, T-Cell↑, 1, TCF↓, 1, TCF↝, 1, Th1 response↑, 1, Th17↑, 1, TLR4↓, 5, TLR4↑, 1, TNF-α↓, 11, TNF-α↑, 2, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1, TRADD↑, 1,

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1, e-pH↑, 2, i-pH↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1, AhR↓, 1, AR↓, 4, CYP19↓, 1, ER-α36↓, 1, Estro↝, 1, PPARγ↑, 1, RANKL↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1, ABCG2↓, 2, BioAv↓, 22, BioAv↑, 19, BioAv↝, 5, BioEnh↑, 2, CBR1↓, 1, ChemoSen↓, 4, ChemoSen↑, 77, CompStab?, 1, CompStab↓, 1, CYP1A1↑, 2, CYP1A2↑, 1, CYP2A3/CYP2A6↓, 1, CYP2E1↑, 1, CYP3A4↓, 2, Dose?, 1, Dose↓, 2, Dose↑, 2, Dose⇅, 1, Dose↝, 32, Dose∅, 7, eff↓, 46, eff↑, 57, eff↝, 5, eff∅, 1, GSTZ1↓, 1, Half-Life↓, 6, Half-Life↝, 3, MDR1↓, 7, P-gp/ABCB1↓, 12, P-gp/ABCB1↝, 1, P450↓, 1, RadioS↑, 27, selectivity↓, 1, selectivity↑, 37, selectivity∅, 1, Synergy?, 1, Synergy↑, 57, Synergy↝, 1,

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1, AFP↓, 1, ALAT↓, 2, ALP↓, 1, AR↓, 4, AST↓, 2, BRCA1↓, 1, BRCA1↝, 1, CA19-9↓, 1, CEA↓, 1, EGFR↓, 13, EZH2↓, 2, Ferritin↓, 6, FOXM1↓, 1, HER2/EBBR2↓, 6, hTERT/TERT↓, 4, IL6↓, 13, LDH↓, 8, LDH↑, 2, p‑LDH↓, 1, Myc↓, 2, PD-L1↓, 4, PSA↓, 1, RAGE↓, 2, TP53↓, 1, TP53↑, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1, AntiCan↓, 3, AntiCan↑, 33, antiD↑, 1, antiNeop↑, 2, AntiTum↑, 14, cachexia↓, 1, cardioP↑, 4, CardioT↑, 1, chemoP↑, 11, chemoPv↑, 8, ChemoSideEff↓, 4, cognitive↑, 1, fatigue↓, 2, hepatoP↓, 1, hepatoP↑, 1, hepatoP∅, 1, Mucositis↓, 1, neuroP↑, 2, OS↑, 9, OS∅, 1, PFS∅, 1, QoL↑, 4, radioP↑, 1, Remission↑, 1, RenoP↑, 3, Risk↓, 9, Sleep↑, 1, toxicity↓, 15, toxicity↑, 3, toxicity↝, 9, toxicity∅, 3, TumVol↓, 21, TumW↓, 13, Weight∅, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1, AntiP↑, 1, Bacteria↓, 2, GutMicro↑, 2,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 7,
Total Targets: 896

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, antiOx↑, 27, ARE↑, 1, Catalase↑, 9, GPx↑, 7, GPx1↑, 2, GPx4↑, 2, GSH↑, 2, GSR↑, 1, GSTs↑, 3, HO-1?, 1, HO-1↑, 4, i-Iron↓, 1, lipid-P↓, 8, MDA↓, 5, MPO↓, 1, NQO1↑, 1, NRF2↑, 11, ROS↓, 29, ROS↑, 1, SOD↑, 10, SOD1↑, 3, SOD2↑, 1, TAC↑, 2, xCT/SLC7A11↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↑, 1, mtDam↓, 1, OCR↓, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2, AMPK↑, 1, glucose↓, 2, glucose↝, 1, H2S↑, 1, LDL↓, 3, SIRT1↑, 1,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3, BAX↓, 2, Casp3↓, 4, Casp9↓, 2, Cyt‑c↓, 1, Ferroptosis↓, 1, iNOS↓, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1, Akt↑, 2, p‑Akt↑, 1, CREB↑, 1, MAPK↓, 3, mTOR↓, 1, mTOR↑, 1, PDGFR-BB↓, 1, PDGFRB↓, 1, PI3K↓, 1, PI3K↑, 2, STAT↓, 1, STAT3↑, 1, p‑STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3, HOTAIR↑, 1, other↑, 2, other↝, 5,

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1, HSP70/HSPA5↑, 1, HSPs↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1, DNArepair↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

AntiAg↑, 2, AP-1↓, 1, Cartilage↑, 1, MMP9↓, 1, PAI-1/SERPINE1↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

E-sel↓, 1, NO↓, 1,

Barriers & Transport(tgid=15) ⓘ

MMP↑, 1, MUC5AC↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1, CD8+↑, 1, COX1↓, 1, COX2/PTGS2↓, 5, CXCR4↓, 1, IL10↓, 1, IL17↓, 2, IL18↓, 1, IL1β↓, 3, IL2↓, 1, IL6↓, 8, IL8↓, 2, Imm↑, 2, Imm↝, 1, Inflam↓, 31, NeuroI↓, 1, NF-kB?, 1, NF-kB↓, 10, NF-kB↑, 1, NLRP3↓, 3, NLRP3↑, 2, PGE2↓, 2, TNF-α↓, 10,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1, AChE↓, 1, BDNF↑, 4, GABA↑, 1, NGF↑, 1, TrkB↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, Aβ↓, 4, p‑tau↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 14, BioAv↑, 10, BioAv↝, 5, CompStab↑, 1, CYP1A1↑, 1, CYP1A2↑, 1, CYP2D6↓, 1, Dose⇅, 2, Dose↝, 10, eff↑, 1, eff↝, 1, Half-Life↑, 1, Half-Life↝, 2, Synergy↑, 2,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2, AST↓, 2, BloodF↑, 1, BP↓, 1, BUN↓, 1, colonLen↑, 1, creat↓, 1, CRP↓, 2, IL6↓, 8, LDH↓, 1, Urea↓, 1,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1, AntiAge↑, 3, antiAll↑, 2, AntiArt↑, 4, AntiCan↓, 1, AntiCan↑, 9, antiCG↑, 1, antiD↓, 1, AntiDiabetic↑, 8, AntiTum↑, 4, cardioP↑, 17, chemoP↑, 2, chemoPv↑, 1, cognitive↑, 6, cough?, 1, hepatoP↑, 11, memory↑, 4, neuroP?, 1, neuroP↓, 1, neuroP↑, 21, Obesity↓, 2, OS↑, 1, Pain↓, 1, QoL↑, 1, RenoP↑, 4, Risk↓, 1, SoreThr?, 1, Stroke↓, 6, Stroke↝, 1, toxicity?, 1, toxicity↓, 11, toxicity↑, 2, toxicity↝, 11,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5, AntiFungal↓, 1, AntiFungal↑, 2, AntiP↑, 6, AntiViral↑, 6, Bacteria↓, 8, Diar↓, 1, GutMicro↑, 4, Sepsis↓, 2,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,
Total Targets: 178

Scientific Paper Hit Count for: TumAuto, Tumor autophagy

15 Curcumin
13 Silver-NanoParticles
11 Artemisinin
9 salinomycin
7 Apigenin (mainly Parsley)
7 EGCG (Epigallocatechin Gallate)
7 Gambogic Acid
7 Ivermectin
6 Magnetic Fields
6 Baicalein
6 Kaempferol
5 Celastrol
5 Eugenol
5 Spermidine
5 itraconazole
5 Licochalcone A
5 Luteolin
5 Matrine
5 Melatonin
5 Shikonin
5 Selenite (Sodium)
4 Radiotherapy/Radiation
4 Allicin (mainly Garlic)
4 Berberine
4 Capsaicin
4 Dandelion Root
4 hydroxychloroquine
4 Ginkgetin
4 Hyperoside
4 Juglone
4 Phenethyl isothiocyanate
4 Urolithin
4 Vitamin K2
3 Astragalus
3 Atorvastatin
3 Betulinic acid
3 Cynaropicrin
3 Dichloroacetate
3 diet Short Term Fasting
3 Fisetin
3 Hibiscus sabdariffa
3 Isoliquiritigenin
3 Sulforaphane (mainly Broccoli)
3 Isovitexin
3 Licorice
3 Quercetin
2 2-DeoxyGlucose
2 3-bromopyruvate
2 Photodynamic Therapy
2 Metformin
2 Ashwagandha(Withaferin A)
2 Boron
2 Centella asiatica / Gotu kola → asiaticoside
2 Chrysin
2 Cranberry
2 Resveratrol
2 diet Methionine-Restricted Diet
2 Chemotherapy
2 Emodin
2 Formononetin
2 Paclitaxel/Taxol
2 Cisplatin
2 Gossypol/AT-101
2 Graviola
2 HydroxyCitric Acid
2 Honokiol
2 isoquercitrin
2 Methyl Jasmonate
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Phenylbutyrate
2 Propolis -bee glue
2 Phycocyanin
2 Psoralidin
2 Silymarin (Milk Thistle) silibinin
2 Ursolic acid
1 cetuximab
1 5-Aminolevulinic acid
1 entinostat
1 wortmannin
1 Allyl isothiocyanate
1 Alpha-Lipoic-Acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Bufalin/Huachansu
1 Benzyl isothiocyanate
1 borneol
1 Beetroot
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Celecoxib
1 chaetocin
1 chitosan
1 Citric Acid
1 Coenzyme Q10
1 Copper and Cu NanoParticles
1 Cucurbitacin
1 CUSP9
1 Diindolylmethane
1 Indole-3-carbinol
1 D-limonene
1 Ellagic acid
1 Bortezomib
1 Estrogen
1 Beta-Caryophyllene
1 5-fluorouracil
1 Evodiamine
1 Ferulic acid
1 Gallic acid
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Hydrogen Gas
1 Calorie Restriction Mimetics
1 Hydroxycinnamic-acid
1 Gemcitabine (Gemzar)
1 Helleborus niger extracts – Christmas Rose
1 Isobavachalcone
1 isoorientin
1 Isothiocyanates
1 Vitexin
1 Magnolol
1 mebendazole
1 immunotherapy
1 Magnetic Field Rotating
1 Magnesium
1 Morin
1 doxorubicin
1 Mushroom Chaga, Inonotus obliquus
1 Myricetin
1 Bicarbonate(Sodium)
1 Naringin
1 Patchouli Oil (Pogostemon cablin)
1 Propyl gallate
1 Piperine
1 Plumbagin
1 Parthenolide
1 Pterostilbene
1 α-Santalol/Sandalwood oil
1 Sesamin
1 Spirulina(Arthrospira/Limnospira)
1 VitK3,menadione
1 Vitamin C (Ascorbic Acid)
1 Zyflamend

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:321  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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