TumCI Cancer Research Results

TumCI, Tumor Cell invasion: Click to Expand ⟱

Source:

Type:

Tumor cell invasion is a critical process in cancer progression and metastasis, where cancer cells spread from the primary tumor to surrounding tissues and distant organs. This process involves several key steps and mechanisms:

1.Epithelial-Mesenchymal Transition (EMT): Many tumors originate from epithelial cells, which are typically organized in layers. During EMT, these cells lose their epithelial characteristics (such as cell-cell adhesion) and gain mesenchymal traits (such as increased motility). This transition is crucial for invasion.

2.Degradation of Extracellular Matrix (ECM): Tumor cells secrete enzymes, such as matrix metalloproteinases (MMPs), that degrade the ECM, allowing cancer cells to invade surrounding tissues. This degradation facilitates the movement of cancer cells through the tissue.

3.Cell Migration: Once the ECM is degraded, cancer cells can migrate. They often use various mechanisms, including amoeboid movement and mesenchymal migration, to move through the tissue. This migration is influenced by various signaling pathways and the tumor microenvironment.

4.Angiogenesis: As tumors grow, they require a blood supply to provide nutrients and oxygen. Tumor cells can stimulate the formation of new blood vessels (angiogenesis) through the release of growth factors like vascular endothelial growth factor (VEGF). This not only supports tumor growth but also provides a route for cancer cells to enter the bloodstream.

5.Invasion into Blood Vessels (Intravasation): Cancer cells can invade nearby blood vessels, allowing them to enter the circulatory system. This step is crucial for metastasis, as it enables cancer cells to travel to distant sites in the body.

6.Survival in Circulation: Once in the bloodstream, cancer cells must survive the immune response and the shear stress of blood flow. They can form clusters with platelets or other cells to evade detection.

7.Extravasation and Colonization: After traveling through the bloodstream, cancer cells can exit the circulation (extravasation) and invade new tissues. They may then establish secondary tumors (metastases) in distant organs.

8.Tumor Microenvironment: The surrounding microenvironment plays a significant role in tumor invasion. Factors such as immune cells, fibroblasts, and signaling molecules can either promote or inhibit invasion and metastasis.

Scientific Papers found: Click to Expand⟱

7549-

HYP,

Rad,

Study on the mechanism of hyperoside in affecting the biological progression and radiosensitivity of esophageal carcinoma by modulating the STAT3/AKT/ERK pathway

-

vitro+vivo,

ESCC,

TE1

-

vitro+vivo,

ESCC,

KYSE150

TumCP↓, TumCI↓, TumCMig↓, EMT↓, Apoptosis↑, RadioS↑, p‑STAT3↓, p‑Akt↓, p‑ERK↓,

7582-

I3C,

Indole-3-Carbinol Promotes Apoptosis and Inhibits the Metastasis of Esophageal Squamous Cell Carcinoma by Downregulating the Wnt/β-Catenin Signaling Pathway

-

vitro+vivo,

ESCC,

NA

nude BALB/c mice bearing EC18 xenografts were treated with I3C and/or LiCl.

Apoptosis↑, TumCMig↓, TumCI↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓,

7584-

I3C,

Functional effect of indole-3 carbinol in the viability and invasive properties of cultured cancer cells

-

in-vitro,

Cerv,

HeLa

-

in-vitro,

CRC,

HCT8

-

in-vitro,

Liver,

HepG2

TumCP↓, Apoptosis↑, TumCI↓, *antiOx↑, AhR↑, MMP↓, Casp3↑, Casp8↑,

7592-

I3C,

Indole-3-carbinol as a chemopreventive and anti-cancer agent

-

Review,

Var,

NA

JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,

7809-

IBC,

Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways

-

in-vitro,

GC,

MGC803

TumCMig↓, TumCI↓, Akt↓, ERK↓, BAX↑, Bcl-2↓, Casp3↑,

7672-

iod,

Adjuvant Effect of Molecular Iodine in Conventional Chemotherapy for Breast Cancer. Randomized Pilot Study

-

Trial,

BC,

NA

 30 patients diagnosed with Early stage breast cancer were enrolled in the study and 23 completed the treatment

Dose↝, OS↑, TumCI↓, Apoptosis↑, EstroRS/ERS↑, Synergy↑, *cardioP↑, *antiOx↑, *Inflam↓,

7682-

iod,

Molecular Iodine Induces Anti- and Pro-Neoplastic Effects in Prostate Cancer Models

-

in-vitro,

Pca,

LNCaP

TRAMP mice (transgenic adenocarcinoma of the mouse prostate

-

in-vitro,

Pca,

DU145

-

in-vitro,

Pca,

PC3

PPARγ↑, antiNeop↑, TumCD↑, TumCI↓, AntiCan⇅, antiOx↑, Inflam↓, Apoptosis↑, tumCV↓,

7686-

iod,

Molecular Iodine Exhibited Differential Antiproliferative Actions in Progenitor and Stem Populations from Chemoresistant Cancer Cells

-

vitro+vivo,

BC,

MCF7

zebrafish xenograft

PPARγ↑, Apoptosis↑, Bax:Bcl2↑, CSCs↓, NRF2↑, tumCV↓, TumCI↓,

7699-

IP6,

IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise

-

Review,

Var,

NA

*Iron∅, ChemoSen↑, *cardioP↑, neuroP↑, IronCh∅, P21↓, p27/CDKN1B↓, p‑pRB↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TumW↓, TumCI↓, TumMeta↓, Imm↑, Diff↑, selectivity↑, toxicity↓, RenoP↑, QoL↑,

7748-

ISL,

GEM,

Isoliquiritigenin combined with gemcitabine inhibited lung cancer by suppressing JAK2/STAT3 signaling via lncRNA-p21/miRNA-4534 axis

-

in-vitro,

Lung,

NA

Dose↝, Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, P21↑, selectivity↑, JAK2↓, STAT3↓,

7756-

ISL,

Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway

-

vitro+vivo,

BC,

MCF7

-

vitro+vivo,

BC,

MDA-MB-231

AntiCan↑, VEGF↓, TumCI↓, TumCMig↓, Hif1a↓, TumCG↓, angioG↓, VEGFR2/KDR/Flk1↓, Apoptosis↑, toxicity↓, TumCCA↑, Inflam↓, ROS↑,

7757-

ISL,

Isoliquiritigenin Suppresses Oral Squamous Cell Carcinoma Progression by Targeting FABP5-Mediated Lipid Metabolism: Association with the circPOLB/miR-548ae-3p/C-MYC Axis

-

in-vitro,

Oral,

NA

FABP5/E-FABP↓, FAM↓, TumCI↓, lipidLev↓,

7783-

ISL,

Isoliquiritigenin Inhibits Ovarian Cancer Metastasis by Reversing Epithelial-to-Mesenchymal Transition

-

vitro+vivo,

Ovarian,

SKOV3

mice

-

in-vitro,

Ovarian,

OVCAR-3

EMT↓, E-cadherin↑, TumCMig↓, TumCI↓, OS↑, Zeb1↓, Vim↓, N-cadherin↓,

7730-

isoFl,

Anticancer Potential of Isoflavones: A Narrative Overview of Mechanistic Insights and Experimental Evidence from the Past Ten Years

-

Review,

Var,

NA

Apoptosis↑, ROS↓, TumCCA↓, TumCMig↓, TumCI↓, MMP↓, angioG↓, ChemoSen↑, p‑Akt↓, p‑mTOR↓, cl‑PARP↑, cycA1/CCNA1↓, CycB/CCNB1↓, STAT3↓,

7859-

isoO,

Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells

-

in-vitro,

PC,

PANC1

tumCV↓, Apoptosis↑, EMT↓, MMPs↓, VEGF↓, AMPK↑, TumCP↓, Dose↝, TumCMig↓, TumCI↓,

7869-

isoO,

Apoptosis induction and inhibition of invasion and migration in gastric cancer cells by Isoorientin studied using network pharmacology

-

in-vitro,

GC,

HGC27

69.7 µM at 48 h

TumCP↓, TumCMig↓, TumCI↓, BAX↑, Casp3↑, p‑PI3K↓, p‑Akt↓, Bcl-2↓, TumCCA↑, ROS↑,

7796-

ISQ,

Isoquercitrin restrains the proliferation and promotes apoptosis of human osteosarcoma cells by inhibiting the Wnt/β-catenin pathway

-

vitro+vivo,

OS,

143B

nude mouse xenograft

-

in-vitro,

OS,

U2OS

TumCP↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, Apoptosis↑, TumMeta↓, TumCCA↑, BAX↑, cl‑Casp3↑, Bcl-2↓,

7845-

ISQ,

Isoquercitrin, ingredients in Tetrastigma hemsleyanum Diels et Gilg, inhibits hepatocyte growth factor/scatter factor-induced tumor cell migration and invasion

-

vitro+vivo,

Bladder,

NBT-II

rat

p‑MET↓, TumCMig↓, TumCI↓, EMT↓, *Inflam?, *antiOx↑, *ROS↓, *lipid-P↓, *neuroP↑,

7997-

itraC,

Anti-fungal drug itraconazole exerts anti-cancer effects in oral squamous cell carcinoma via suppressing Hedgehog pathway

-

vitro+vivo,

SCC,

NA

TumCP↓, TumCCA↑, Apoptosis↑, TumCI↓, TumCMig?, TumCG↓, Ki-67↓, HH?,

7994-

itraC,

From fungus fighter to cancer slayer: itraconazole as a multifaceted candidate for drug-resistant prostate cancer

-

Review,

Pca,

NA

HH↓, Gli1↓, TumCP↓, TumCI↓, Synergy↑,

8043-

IVM,

Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma

-

vitro+vivo,

ESCC,

KYSE-30

-

in-vitro,

ESCC,

KYSE70

-

in-vitro,

ESCC,

KYSE150

tumCV↓, Apoptosis↑, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, PAK1↓, ChemoSen↑, cl‑PARP↑, Casp3↑, TumMeta↓,

7892-

IVT,

Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway

-

in-vitro,

Nor,

HCEC 1CT

-

in-vivo,

Colon,

NA

TumCP↓, selectivity↑, TumCMig↓, TumCI↓, EMT↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Bcl-2↓, BAX↑, Casp3↑, TumVol↓, TumW↓,

7965-

JG,

Mechanistic investigation of Juglone (5-hydroxy-1,4-naphthoquinone) as an anti-cancer agent in human colorectal cancer HCT116 and HT-29 cell lines

-

in-vitro,

CRC,

HCT116

-

in-vitro,

CRC,

HT-29

Apoptosis↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Bcl-2↓, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, ERK↓, AKT1↓, p38↑, JNK↑, TumCMig↓, TumCI↓, TumMeta↓,

974-

JG,

Juglone down-regulates the Akt-HIF-1α and VEGF signaling pathways and inhibits angiogenesis in MIA Paca-2 pancreatic cancer in vitro

-

in-vitro,

PC,

MIA PaCa-2

100nM-10uM

Hif1a↓, VEGF↓, p‑Akt↓, TumCP↓, TumCI↓,

5115-

JG,

Natural Products to Fight Cancer: A Focus on Juglans regia

-

Review,

Var,

NA

Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, Synergy↑, BAX↑, Fas↑, Pin1↓,

1924-

JG,

Juglone triggers apoptosis of non-small cell lung cancer through the reactive oxygen species -mediated PI3K/Akt pathway

-

in-vitro,

Lung,

A549

2-8uM

9.47 μM@24h

TumCMig↓, TumCI↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Cyt‑c↑, ROS↑, MDA↑, GPx4↓, SOD↓, PI3K↓, Akt↓, eff↓,

8089-

KAE,

Kaempferol impairs aerobic glycolysis against melanoma metastasis via inhibiting the mitochondrial binding of HK2 and VDAC1

-

in-vitro,

Melanoma,

A375

-

in-vitro,

Melanoma,

B16-F10

TumCMig↓, TumCI↓, TumMeta↓, ECAR↓, GlucoseCon↓, ATP↓, Pyruv↓, lactateProd↓, HK2↓, VDAC1↓, Akt↓, GSK‐3β↝, Glycolysis↓,

8072-

KAE,

Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation

-

Review,

CRC,

NA

AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, Synergy↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,

8237-

LCA,

Role of Licochalcone A in Potential Pharmacological Therapy: A Review

-

Review,

Var,

NA

*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑, *antiAll↑, *MUC5AC↓, *E-sel↓, *CCL11↓,

8243-

LCA,

Licochalcone A Inhibits Cellular Motility by Suppressing E-cadherin and MAPK Signaling in Breast Cancer

-

in-vitro,

BC,

MDA-MB-231

Inflam↓, AntiTum↑, TumAuto↑, Sp1/3/4↓, TumCMig↓, MAPK↓, Akt↓, cl‑Casp3↑, cl‑Casp9↑, Bcl-2↓, Cyt‑c↑, TumCP↓, ROS↑, Apoptosis↑, TumCMig↓, TumCI↓, MMP↓, γH2AX↑,

8251-

LCA,

Licochalcone A inhibits the migration and invasion of human lung cancer cells via inactivation of the Akt signaling pathway with downregulation of MMP-1/-3 expression

-

in-vitro,

Lung,

A549

-

in-vitro,

Lung,

H460

TumCMig↓, TumCI↓, MMP1↓, MMP3↓, p‑Akt↓, Akt↓, Sp1/3/4↓,

8275-

LCA,

Licochalcone A inhibits glioma migration, invasion, and growth by triggering mitochondrial dysfunction and ROS-mediated oxidative damage

-

vitro+vivo,

GBM,

NA

AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, mtDam↑, Bcl-2↓, ROS↑,

8235-

LCA,

Anticancer effects of licochalcones: A review of the mechanisms

-

Review,

Var,

NA

mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,

8229-

LCA,

Licochalcone A: a review of its pharmacology activities and molecular mechanisms

-

Review,

Nor,

NA

*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,

8232-

LCA,

Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study

-

vitro+vivo,

ESCC,

NA

TumCP↓, TumCMig↓, TumCI↓, MMPs↓, ROS↑, MMP↓, BAX↑, Casp3↑, Casp9↑, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK1↓, P53↑, TumCG↓, toxicity↓,

8338-

LDN,

Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway

-

vitro+vivo,

Cerv,

HeLa

mice

-

in-vitro,

Cerv,

SiHa

TumCP↓, TumCMig↓, TumCI↓, PI3K↓, p‑Akt↓, mTOR↓, OGFr↑, Dose↝, *toxicity↝, chemoP↑, ChemoSen↑,

8339-

LDN,

Low-dose naltrexone inhibits the epithelial-mesenchymal transition of cervical cancer cells in vitro and effects indirectly on tumor-associated macrophages in vivo

-

in-vivo,

Cerv,

HeLa

TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, TAMS↓, M2 MC↓, IL10↓, OGFr↑, chemoP↑,

8291-

LE,

Glycyrrhizic acid inhibits leukemia cell growth and migration via blocking AKT/mTOR/STAT3 signaling

-

vitro+vivo,

AML,

TF1

*Ingr↝, *AntiViral↑, *AntiCan↑, *Inflam↓, TumCMig↓, TumCI↓, Akt↓, mTOR↓, STAT3↓, Dose↝,

8288-

LE,

18 β-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration

-

vitro+vivo,

CRC,

NA

TumCP↓, survivin↓, cl‑PARP↑, TumCMig↓, Wound Healing↓, TumCI↓, MMPs↓, p‑PI3K↓, p‑Akt↓, p‑STAT↓,

8143-

LF,

Lactoferrin mediates epithelial-mesenchymal transformation by regulating the PI3K/AKT/mTOR pathway to inhibit nasopharyngeal carcinoma metastasis

-

in-vitro,

NPC,

NA

TumCP↓, TumCI↓, TumCMig↓, EMT↓, NA?,

8298-

lign,

Inhibitory Effects of Enterolactone on Growth and Metastasis in Human Breast Cancer

-

in-vitro,

BC,

MDA-MB-231

Risk↓, TumCP↓, Ki-67↓, PCNA↓, FOXM1↓, TumCCA↑, cycE/CCNE↓, cycA1/CCNA1↓, CycB/CCNB1↓, FAK↓, pax↓, TumCMig↓, TumCI↓,

8324-

LIN,

Linalool targets NR3C2 to inhibit NF-κB-mediated gastric cancer progression

-

vitro+vivo,

GC,

NA

nude mice

TumCP↓, TumCMig↓, TumCI↓, NR3C2/MR↑, NR3C2/MR↑, NFKBIZ/IκBζ↓,

8325-

LIN,

Validating linalool as a potential drug for breast cancer treatment based on machine learning and molecular docking

-

in-vitro,

BC,

NA

tumCV↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, TumCCA↑, PPARγ↑, PGK1↓,

8375-

LT,

Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches

-

Review,

Var,

NA

TumCP↓, TumCI↓, Apoptosis↑, TumCCA↑, Inflam↓, Ferroptosis↑, Pyro↑, ChemoSen↑, chemoP↑, *BioAv↓, OATPs↓,

8384-

LT,

Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors

-

Review,

GC,

NA

Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,

8390-

LT,

Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective

-

Review,

IBD,

NA

-

Review,

CRC,

NA

*Diff↝, *Inflam↓, *ROS↓, *GutMicro↑, *IBI↑, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, *BioAv↑, *iNOS↓, *TNF-α↓, *IL6↓, *MDA↓, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *Catalase↑, *5HT↓, *TPH1↓, *MAPK↓, *ERK↓, *Inflam↓, cycD1/CCND1↓, CDK4↓, TumCCA↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, E-cadherin↑, N-cadherin↓, Vim↓,

8400-

LT,

Luteolin inhibits triple-negative breast cancer by inducing apoptosis and autophagy through SGK1-FOXO3a-BNIP3 signaling

-

in-vitro,

BC,

NA

TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, SGK1↓, AKT3↓, BNIP3↑,

8397-

LT,

Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules

-

Review,

Var,

NA

tumCV↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, mTOR↓, PI3K↓, Akt↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Apoptosis↑, hTERT/TERT↓, AP-1↓, NF-kB↓, MAPK↓, HSP90↓, AR↓, IGF-1R↓, Akt↓, NOTCH↓, IL6↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, TumVol∅, TumW∅, miR-34a↑, miR-107↑, miR-139-5p↑, miR-422a↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, *toxicity↓,

8371-

LT,

Study on the regulatory mechanism of luteolin inhibiting WDR72 on the proliferation and metastasis of non small cell lung cancer

-

vitro+vivo,

Lung,

A549

-

in-vitro,

Lung,

H1299

-

in-vitro,

Nor,

BEAS-2B

TumCP↓, TumCI↓, TumCMig↓, TumVol↓, p‑Akt↓, Apoptosis↓, EMT↓, Dose↝, Akt↓, WDR72↓, TumMeta↓,

4687-

LT,

QC,

Dietary Flavonoids Luteolin and Quercetin Suppressed Cancer Stem Cell Properties and Metastatic Potential of Isolated Prostate Cancer Cells

-

in-vitro,

Pca,

DU145

CSCs↓, EMT↓, MMPs↓, TumCMig↓, TumCI↓,

Showing Research Papers: 301 to 350 of 545
Prev Page 7 of 11 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 545

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

NA↑, 1, NA?, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1, antiOx↓, 2, antiOx↑, 6, ARE↓, 1, Catalase↓, 3, Copper↑, 1, ENOX2↓, 1, Fenton↑, 2, GPx↓, 1, GPx↑, 2, GPx1↓, 1, GPx4↓, 13, GSH↓, 27, GSH↑, 2, GSR↓, 1, GSTs↑, 1, H2O2↓, 2, H2O2↑, 2, HO-1↓, 5, HO-1↑, 9, Iron↑, 4, i-Iron↑, 1, Keap1↓, 1, Keap1↑, 1, lipid-P?, 1, lipid-P↓, 3, lipid-P↑, 8, MDA?, 1, MDA↑, 7, i-MDA↑, 1, NADH↓, 2, NQO1?, 1, NQO1↑, 1, NRF2↓, 16, NRF2↑, 15, Prx↓, 1, Prx4↑, 1, PrxII↓, 1, PYCR1↓, 1, ROS↓, 19, ROS↑, 146, ROS⇅, 2, ROS↝, 2, ROS∅, 1, i-ROS↓, 1, i-ROS↑, 1, mt-ROS↑, 5, SOD↓, 5, SOD↑, 2, SOD1↓, 1, SOD1↑, 1, SOD2↓, 4, SOD2↑, 1, TAC↓, 1, TAC↑, 1, TKT↝, 1, Trx↓, 2, ox-Trx1↑, 1, TrxR↓, 5, TrxR1↓, 3, xCT/SLC7A11↓, 5,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1, IronCh∅, 1, Tf↓, 1, Tf↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1, CDC2↓, 4, CDC25↓, 6, compI↓, 1, compIII↓, 1, compV↓, 1, compV↓, 1, EGF↓, 1, ETC↓, 3, MFN2↓, 1, mitResp↑, 1, Mortalin↓, 1, mtDam↑, 14, OCR↓, 6, OCR↑, 1, OXPHOS↓, 2, OXPHOS↑, 5, mt-OXPHOS↓, 1, PDH↑, 2, PDH↝, 1, PDH∅, 1, PGC-1α↑, 1, PINK1↑, 3, SIRT3↑, 2, VDAC1↓, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2, 5LO↓, 3, ACADS/SCAD↓, 1, ACC↓, 2, ACLY↓, 1, ACSL4↑, 1, ALAT↓, 2, AMPK↓, 1, AMPK↑, 25, AMPK↝, 1, p‑AMPK↑, 5, ATP↓, 19, CAIX/CA9↓, 1, citrate↓, 1, ECAR↓, 3, ENO1↓, 1, FABP4↑, 1, FABP5/E-FABP↓, 1, FAM↓, 1, FASN↓, 6, FDG↓, 1, G6PD↓, 5, GAPDH↓, 2, GLS↓, 1, glucoNG↓, 1, GlucoseCon↓, 11, GlutMet↓, 1, Glycolysis↓, 34, GSK‐3β↓, 10, GSK‐3β↑, 1, GSK‐3β↝, 1, p‑GSK‐3β↓, 1, Histones↑, 1, ac‑Histones↑, 1, HK1↓, 1, HK2↓, 17, HMG-CoA↓, 1, IDH1↑, 1, lactateProd↓, 11, lactateProd↑, 1, LDHA↓, 11, LDHA∅, 1, LDL↓, 3, lipidLev↓, 2, lipoGen↓, 2, NADPH↓, 1, PDHB↓, 1, PDK1 / PDPK1↓, 5, p‑PDK1 / PDPK1↓, 1, PFK↓, 4, PFK1↓, 1, PGK1↓, 2, PGM1↓, 1, PIP3↑, 1, PKM2↓, 19, PKM2∅, 1, Pyruv↓, 1, R5P↝, 1, RARα↓, 1, RARβ↑, 1, RARγ↑, 1, p‑S6↓, 1, SCD1↓, 2, SIRT1↓, 5, SIRT1↑, 4, SIRT2↑, 1, SREBP1/SREBF1↓, 3, SREBP2↓, 2, TCA↓, 1, Warburg↓, 8,

Cell Death(tgid=5) ⓘ

AIF↑, 4, APAF1↑, 6, Apoptosis?, 3, Apoptosis↓, 7, Apoptosis↑, 233, mt-Apoptosis↑, 1, ASC↓, 1, ASC↑, 1, ASK1↑, 1, BAD↓, 1, BAD↑, 3, Bak↑, 2, BAX↓, 1, BAX↑, 84, Bax:Bcl2↑, 14, Bcl-2↓, 99, Bcl-xL↓, 15, BIM↑, 2, BNIP3↑, 1, Casp↑, 23, Casp1↓, 1, Casp1↑, 1, cl‑Casp1↑, 1, proCasp1↓, 1, Casp10↓, 1, Casp10∅, 1, Casp12↑, 1, cl‑Casp12↑, 1, Casp2↑, 1, Casp3↓, 2, Casp3↑, 94, cl‑Casp3↑, 24, Casp7↑, 13, cl‑Casp7↑, 1, Casp8↓, 1, Casp8↑, 23, Casp8∅, 1, cl‑Casp8↑, 3, proCasp8↑, 1, Casp9↓, 1, Casp9↑, 58, p‑Casp9↑, 1, cl‑Casp9↑, 8, cFLIP↓, 2, Cupro↑, 1, Cyt‑c↓, 2, Cyt‑c↑, 47, Cyt‑c↝, 1, DR5↑, 10, DR5∅, 1, Endon↑, 1, FADD↑, 3, FADD∅, 1, Fas↓, 2, Fas↑, 11, FasL↓, 1, FasL↑, 4, Ferroptosis↑, 22, GSDMD↑, 2, IAP1↓, 5, IAP2/BIRC3↓, 2, cl‑IAP2/BIRC3↑, 1, iNOS↓, 7, Mcl-1↓, 10, Mcl-1↑, 1, MDM2↓, 7, MDM2↑, 1, MOMP↓, 1, MOMP↑, 3, Necroptosis↑, 2, necrosis↑, 2, NOXA↑, 2, P2X7↓, 1, p38↓, 6, p38↑, 9, p‑p38↓, 4, p‑p38↑, 3, p‑p38↝, 1, Paraptosis↑, 1, PDCD4↑, 1, PUMA↑, 2, Pyro↑, 3, RIP1↓, 1, survivin↓, 38, TNFR 1↓, 1, TRAILR↑, 1, TumCD↓, 1, TumCD↑, 9, TUNEL↑, 1, XIAP↓, 19, YAP/TEAD↓, 6, YAP/TEAD↑, 1, β-TRCP↑, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1, Akt↓, 122, Akt↑, 5, Akt↝, 1, p‑Akt↓, 43, p‑Akt↑, 1, AKT1↓, 4, AKT3↓, 1, p‑CaMKII ↓, 1, CIP2A↓, 1, CK2↓, 4, cMET↓, 1, p‑cMET↑, 2, cSrc↓, 1, EF-1α↓, 1, EGFR↓, 34, p‑EGFR↓, 1, ERK↓, 31, ERK↑, 7, ERK↝, 2, p‑ERK↓, 17, p‑ERK↑, 1, p‑ERK↝, 1, FGFR1↓, 1, HER2/EBBR2↓, 10, p‑HER2/EBBR2↓, 1, IGF-1R↓, 2, IGFR↓, 1, p‑IGFR↓, 1, IKKα↓, 10, IKKα↝, 1, p‑IKKα↓, 1, IR↓, 1, IκB↑, 1, p‑IκB↓, 1, p‑IκB↑, 1, JAK↓, 6, JAK↝, 1, p‑JAK↓, 1, JAK1↓, 2, JAK2↓, 11, p‑JAK2↓, 2, p‑JAK3↓, 1, JNK↓, 3, JNK↑, 10, JNK↝, 1, p‑JNK↓, 2, p‑JNK↑, 1, p‑JNK↝, 1, p‑MAP2K1/MEK1↓, 1, MAPK↓, 27, MAPK↑, 9, MAPK↝, 1, p‑MAPK↓, 2, p‑MAPK↑, 1, MEK↓, 4, p‑MEK↓, 2, mTOR↓, 66, mTOR↑, 4, mTOR↝, 1, p‑mTOR↓, 12, mTORC2↓, 2, mTORC2↑, 1, NRAS↓, 1, p42↑, 1, P70S6K↓, 4, p‑P70S6K↓, 1, P90RSK↓, 1, p‑P90RSK↑, 1, p‑PDGFR-BB↓, 1, PDGFRA↓, 1, PFKFB2↓, 1, PI3K↓, 82, PI3K↝, 1, p‑PI3K↓, 13, PI3K/Akt↓, 4, PI3k/Akt/mTOR↓, 1, PIK3CA↓, 1, PKA↓, 1, PKCδ↓, 8, p‑PKCδ↓, 1, PP2A↑, 1, PRAS40↑, 1, PTEN↑, 22, PTK2B / PYK2↓, 1, Raf↓, 3, c-Raf↓, 1, RAS↓, 10, RAS↑, 1, p‑S6K↓, 1, SGK1↓, 1, Sp1/3/4↓, 19, Src↓, 4, p‑Src↓, 1, STAT↓, 6, p‑STAT↓, 1, p‑STAT2↓, 1, STAT3↓, 57, STAT3↑, 3, p‑STAT3↓, 10, p‑STAT3↑, 2, STAT5↓, 1, STAT6↓, 3, THEM4/CTMP↑, 1, TSC2↑, 2, p‑TSC2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2, ATF4↑, 6, ATF4↝, 1, CBP↓, 2, cJun↓, 6, cJun↑, 2, p‑cJun↓, 1, cMyc↓, 26, DNMT1↓, 4, DNMT1↑, 1, DNMTs↓, 2, EZH2↓, 1, FOXM1↓, 2, FOXO↑, 2, FOXO1↓, 2, FOXO1↑, 1, FOXO3↑, 4, p‑FOXO3↓, 1, FOXO4↓, 1, FOXO4↑, 1, H3↑, 1, ac‑H3↑, 2, H4↑, 2, ac‑H4↑, 1, HATs↓, 5, HATs↑, 1, HDAC↓, 11, HDAC1↓, 4, HDAC3↓, 1, HDAC4↓, 1, HDAC6↓, 2, HDAC8↓, 1, HES1↓, 2, HMTs↓, 1, HOXB-AS1↓, 1, JPT1/HN1↓, 1, KISS1↑, 1, LINC01116↓, 1, Matr↓, 1, METTL7A↑, 1, miR-107↑, 2, miR-10b-5p↓, 1, miR-124-3p↓, 1, miR-130a↓, 2, miR-133a-3p↑, 1, miR-139-5p↑, 3, miR-145↑, 1, miR-149↑, 1, miR-155↓, 2, miR-182-5p↓, 1, miR-192-5p↑, 1, miR-194↑, 1, miR-200b↑, 1, miR-205↑, 2, miR-206↑, 1, miR-21↓, 8, miR-223-3p↓, 1, miR-224↓, 2, miR-25-5p↓, 1, miR-29b↑, 1, miR-301a-3p↓, 1, miR-30a-5p↑, 1, miR-340↓, 2, miR-34a↓, 1, miR-34a↑, 5, miR-375↑, 2, miR-384↑, 1, miR-422a↑, 2, miR-542↓, 1, miR-590-3p↑, 1, miR-592↑, 1, miR-7641↓, 1, miR-99↑, 1, Myc↓, 1, Myc↑, 1, NDRG1↑, 1, OCT4↓, 12, other?, 1, other↓, 2, other↑, 3, other↝, 11, PCAF↓, 1, PhotoS↑, 2, RASSF1A↑, 1, sonoS↑, 1, SOX2↓, 10, SOX4↓, 1, SOX4↑, 1, SUV39H↓, 1, TCF-4↓, 1, TLE1↓, 1, tumCV↓, 71, tumCV∅, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 18, cl‑CHOP/DDIT3↑, 1, CUL1↝, 1, CUL5↝, 1, eIF2α↓, 1, eIF2α↑, 4, p‑eIF2α↑, 2, ER Stress↑, 27, Erlin1↑, 1, GRP78/BiP?, 1, GRP78/BiP↓, 2, GRP78/BiP↑, 8, HSP70/HSPA5↓, 3, HSP70/HSPA5↑, 1, e-HSP70/HSPA5↓, 1, HSP90↓, 13, HSPs↓, 1, IRE1↑, 3, OTUB2↓, 1, PDI↑, 1, PERK↑, 9, p‑PERK↑, 1, Proteasome↓, 1, UPR↓, 1, UPR↑, 2, XBP-1↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1, ATG16L1↑, 1, ATG3↑, 1, ATG5↓, 1, ATG5↑, 2, ATG7↑, 2, Beclin-1/ATG6↓, 4, Beclin-1/ATG6↑, 5, LC3‑Ⅱ/LC3‑Ⅰ↑, 3, LC3A↑, 2, LC3B↑, 1, LC3B-II↓, 1, LC3B-II↑, 1, LC3I↑, 1, LC3II↓, 1, LC3II↑, 7, LC3s↑, 1, MitoP↑, 1, p62↓, 4, p62↑, 3, p‑p62↑, 1, PARK2↑, 3, RUBCN↓, 1, SESN2↑, 1, TumAuto↓, 1, TumAuto↑, 42, TumAuto⇅, 1, TumAuto↝, 1, ULK1/ATG1↑, 1, VMP-1↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3, BRCA1↓, 2, BRCA1↑, 2, BRCA2↑, 1, DNAdam↓, 1, DNAdam↑, 33, DNArepair↓, 5, ERCC1↓, 2, ERCC3↑, 1, ERCC4/XPF↓, 1, m-FAM72A↓, 1, hTERT/TERT↓, 3, Ku70/XRCC6↓, 1, p16↑, 2, P53?, 1, P53↓, 1, P53↑, 50, p‑P53↑, 3, p73↑, 1, PARP↓, 3, PARP↑, 9, cl‑PARP↑, 42, PARP1↑, 1, cl‑PARP1↑, 1, PCNA↓, 21, PCNA↑, 1, POLD1↓, 1, Telomerase↓, 5, TOP1↓, 3, TOP2↓, 2, TOP2↑, 1, TP53↑, 2, XRCC1↓, 1, γH2AX↑, 5, γH2AX↝, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 2, CDK1↓, 9, CDK1↑, 1, CDK2↓, 20, CDK2↑, 3, CDK4↓, 25, CDK4↑, 2, CDK4∅, 1, CDK4/6↓, 1, CDK6↓, 10, CDK6↑, 2, CDK6∅, 1, CDK7↓, 1, cellSen↑, 1, CHK1↓, 1, CHK1↑, 1, p‑CHK1↑, 1, Chk2↑, 1, p‑Chk2↑, 1, Cyc↓, 1, cycA1/CCNA1↓, 7, CycB/CCNB1↓, 15, cycD1/CCND1↓, 53, cycD1/CCND1↑, 2, cycD1/CCND1∅, 1, CycD3↓, 3, cycE/CCNE↓, 14, E2Fs↓, 2, Ki-67↓, 31, MAD↓, 1, P21?, 1, P21↓, 3, P21↑, 40, p27/CDKN1B↓, 2, p27/CDKN1B↑, 10, p‑pRB↓, 2, RB1↓, 1, RB1↑, 1, p‑RB1↓, 3, RRM2↓, 1, Securin↓, 1, TumCCA↓, 6, TumCCA↑, 149, WEE1↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2, p‑4E-BP1↓, 2, ALDH↓, 8, ALDH1A1↓, 1, Axin2↑, 1, BMI1↓, 1, BMP2↓, 1, BMPs↑, 2, CD133↓, 11, CD133↑, 1, CD24↓, 4, CD34↓, 1, cFos↓, 7, p‑cFos↓, 1, cMYB↓, 1, CSCs↓, 38, Diff↑, 5, FGF↓, 2, FGF↑, 1, Gli↓, 1, Gli1↓, 13, HH?, 1, HH↓, 12, IGF-1↓, 4, IGFBP3↓, 1, IGFBP3↑, 2, JAG1↓, 1, Jun↓, 2, Ki-67↓, 31, Let-7↑, 1, LRP6↓, 2, p‑LRP6↓, 2, MCM2↓, 1, mTORC1↓, 5, Nanog↓, 10, Nestin↓, 3, NOTCH↓, 10, NOTCH↑, 1, NOTCH1↓, 5, NOTCH1↝, 1, NOTCH3↓, 3, OGFr↑, 2, p300↓, 3, PCLAF↓, 1, Piezo1↑, 2, PTCH1↓, 3, PTCH2↓, 1, SCF↓, 1, Shh↓, 4, Smo↓, 6, STAT1↓, 1, p‑STAT1↓, 1, Sufu↓, 1, TAZ↓, 1, TOPflash↓, 2, TumCG?, 2, TumCG↓, 108, TumCG↑, 3, TumCG∅, 1, TumCP?, 1, TumCP↓, 239, TumCP↑, 5, tyrosinase↓, 1, URGCP/URG4↓, 1, WDR72↓, 1, Wnt↓, 30, Wnt/(β-catenin)↓, 7, ZFX↓, 1,

Migration(tgid=13) ⓘ

AGRN↓, 1, annexin II↓, 1, AntiAg?, 1, AntiAg↑, 3, AP-1↓, 10, AP-1↝, 1, ASAP2↓, 1, Ca+2↑, 20, CAFs/TAFs↓, 1, CAFs/TAFs↝, 1, cal2↑, 2, Cav1↓, 1, p‑Cofilin↑, 2, COL11A1↓, 1, E-cadherin↓, 6, E-cadherin↑, 70, EMT?, 1, EMT↓, 124, EMT↑, 4, EpCAM↓, 3, F-actin↓, 3, FAK↓, 14, FAK↑, 1, p‑FAK↓, 3, Fibronectin↓, 7, GLI2↓, 2, ITGA2↓, 1, ITGA5↓, 1, ITGA6↓, 1, ITGB1↓, 4, ITGB3↓, 1, ITGB4↓, 3, ITGB6↓, 1, LAMs↓, 1, LEF1↓, 2, LRP1↓, 1, MALAT1↓, 3, MET↓, 2, MET↑, 1, p‑MET↓, 1, MMP-10↓, 1, MMP1↓, 5, MMP13↓, 5, MMP14↓, 2, MMP16↓, 2, MMP17↓, 1, MMP2?, 1, MMP2↓, 117, MMP2↝, 1, MMP3↓, 8, MMP7↓, 11, MMP9?, 1, MMP9↓, 133, MMP9↑, 1, MMP9↝, 1, MMPs↓, 32, MTA1↓, 2, MUC1↓, 1, MUC4↓, 1, N-cadherin?, 1, N-cadherin↓, 53, NEDD9↓, 3, p44↑, 1, PAK1↓, 1, pax↓, 1, PDGF↓, 4, RECK↑, 2, RHBDD1↓, 1, Rho↓, 5, ROCK1↓, 7, Sharpin↓, 1, Slug↓, 27, Smad1↓, 2, Smad1↑, 1, Smad1↝, 1, SMAD2↓, 4, p‑SMAD2↓, 9, SMAD3↓, 8, p‑SMAD3↓, 7, SMAD4↓, 1, p‑SMAD4↓, 1, Snail↓, 44, Snail↑, 1, T-cadherin↑, 1, talin?, 1, talin↓, 1, TET1↓, 1, TET1↑, 3, TGF-β↓, 17, TGF-β↑, 3, TGF-β↝, 1, TGF-β1↓, 3, THBS1↓, 1, TIMP1↓, 1, TIMP1↑, 7, TIMP2↓, 2, TIMP2↑, 9, TIMP3↑, 2, TRIB3↑, 1, TSC1↑, 1, TSP-1↑, 1, TumCA↓, 10, TumCA↑, 1, TumCI?, 1, TumCI↓, 540, TumCI↑, 7, TumCMig?, 1, TumCMig↓, 344, TumCMig↑, 5, TumMeta↓, 118, TumMeta↑, 5, Twist↓, 16, Twist↑, 1, TXNIP↑, 1, uPA↓, 14, uPAR↓, 2, UroPA↓, 1, Vim?, 1, Vim↓, 58, Vim↑, 1, vinculin↓, 1, Zeb1↓, 17, Zeb1↑, 1, ZEB2↓, 3, ZEB2↑, 1, α-SMA↓, 3, α-SMA↑, 1, α-tubulin↑, 2, β-catenin/ZEB1↓, 53, β-catenin/ZEB1↑, 2, cl‑β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 96, angioG↑, 2, EGR1↓, 1, EGR4↓, 1, eNOS↓, 1, HIF-1↓, 6, Hif1a↓, 52, Hif1a↑, 1, Hif1a↝, 1, NO↓, 1, PHDs↑, 1, TXA2↓, 1, VEGF↓, 69, VEGF↑, 1, VEGFR1↓, 2, VEGFR2/KDR/Flk1↓, 8,

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1, BBB↑, 2, CLDN1↓, 1, CLDN1↑, 1, CX43/GJA1↓, 1, EPR↑, 2, GLUT1↓, 12, GLUT1∅, 1, GLUT3↓, 1, GLUT3∅, 1, MMP↓, 65, MMP↑, 1, MPT↑, 4, OATPs↓, 1, TRPM7↓, 2, TRPM7↑, 1, TRPV1↑, 1, ZO-1↓, 1, ZO-1↑, 4,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1, CD25+↑, 1, CD4+↓, 1, CD4+↑, 2, CD44↓, 13, CD47↓, 1, CD8+↑, 5, p‑cDC2↓, 1, COX1↓, 3, COX2/PTGS2↓, 37, COX2/PTGS2↑, 2, COX2/PTGS2↝, 1, CXCL12↓, 2, CXCR2↓, 1, CXCR4↓, 11, DR4↑, 7, DR4∅, 1, FOXP3↑, 1, Gal-3↓, 2, HLA-I/II↑, 1, HMGB1↓, 2, ICAM-1↓, 4, IFN-γ↑, 1, Igs↑, 1, IL1↓, 3, IL10↓, 1, IL12↓, 1, IL12↑, 1, IL18↓, 2, IL1α↓, 2, IL1β↓, 11, IL2↓, 2, IL6↓, 26, IL6↑, 1, IL8↓, 8, Imm↑, 11, Imm↝, 2, Inflam↓, 34, Inflam↝, 2, IRAK4↓, 1, LIF↑, 1, LRIG1↑, 1, M2 MC↓, 1, MCP1/CCL2↓, 5, MCT1↓, 1, MIP2↓, 1, NF-kB↓, 114, NF-kB↑, 6, NF-kB↝, 2, p‑NF-kB↓, 4, p‑NF-kB↑, 1, NFKBIZ/IκBζ↓, 1, NK cell↑, 3, NLRP3↓, 5, NLRP3↑, 2, p65↓, 5, p‑p65↓, 2, PD-1↓, 3, PD-L1↓, 8, PD-L1↑, 2, PGE2↓, 12, PSA↓, 2, T-Cell↑, 1, TCF↓, 2, Th1 response↑, 1, TLR2↓, 1, TLR4↓, 8, TNF-α↓, 20, TNF-α↑, 3, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1, WFDC10A↑, 1,

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1, pH↑, 1, e-pH↑, 3, i-pH↓, 1, TAMS↓, 1, TAMS↝, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, PTN↓, 1,

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1, XO↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1, AhR↑, 2, AhR↓, 1, AR↓, 10, ER-α36↓, 2, ERα/ESR1↓, 1, Estro↝, 1, EstroRS/ERS↑, 1, FGF21↓, 1, NR3C2/MR↑, 2, PPARα↓, 1, PPARα↑, 1, PPARα↝, 1, PPARγ↑, 5, RANKL↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3, AKR1B10↓, 1, BioAv↓, 22, BioAv↑, 23, BioAv↝, 11, BioEnh?, 1, BioEnh↑, 2, ChemoSen↓, 2, ChemoSen↑, 107, CompStab↓, 1, CYP1A1↓, 1, CYP1A1↑, 1, CYP1A2↑, 1, CYP2A3/CYP2A6↓, 1, CYP2E1↑, 1, CYP3A4↓, 2, DDS↑, 1, Dose↓, 5, Dose↑, 3, Dose↝, 42, Dose∅, 4, eff↓, 20, eff↑, 55, eff↝, 3, eff∅, 1, GSTZ1↓, 1, Half-Life↓, 7, Half-Life↑, 2, Half-Life↝, 7, MDR1↓, 2, MRP1/ABCC1↓, 2, NAT↓, 1, P-gp/ABCB1↓, 14, P450↓, 1, RadioS?, 1, RadioS↑, 31, selectivity↑, 62, Synergy↑, 75,

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1, AFP↓, 1, ALAT↓, 2, ALB↑, 1, ALP↓, 2, AR↓, 10, ascitic↓, 1, AST?, 1, AST↓, 1, BMD↑, 2, BP↓, 1, BRCA1↓, 2, BRCA1↑, 2, CRP↓, 1, DBIL↓, 1, EGFR↓, 34, p‑EGFR↓, 1, ERα/ESR1↓, 1, EstroRS/ERS↑, 1, EZH2↓, 1, Ferritin↓, 1, FOXM1↓, 2, HER2/EBBR2↓, 10, p‑HER2/EBBR2↓, 1, hTERT/TERT↓, 3, IBIL↓, 1, IL6↓, 26, IL6↑, 1, LDH↓, 7, LDH↑, 2, Myc↓, 1, Myc↑, 1, NOS2↓, 1, PD-L1↓, 8, PD-L1↑, 2, PSA↓, 2, TBIL↓, 1, TG/TAG↓, 1, TP53↑, 2, TRIB3↑, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1, AntiCan↑, 32, AntiCan⇅, 1, AntiCan∅, 1, antiD↑, 1, AntiDiabetic↑, 2, antiNeop↑, 3, AntiTum↓, 3, AntiTum↑, 23, cachexia↓, 1, cardioP↑, 6, CardioT↑, 1, chemoP?, 1, chemoP↑, 18, chemoPv↑, 15, ChemoSideEff↓, 3, fatigue↓, 2, FTO↓, 1, FTO↑, 1, hepatoP↓, 1, hepatoP↑, 4, Mucositis↓, 1, neuroP↑, 4, NP/CIPN↓, 1, OS↑, 11, Pain↓, 1, PFS↑, 1, Pin1↓, 1, QoL↑, 5, radioP↑, 6, Remission↑, 1, RenoP↑, 2, Risk↓, 8, Risk↑, 1, Sleep↑, 1, Strength↑, 1, Symptoms↓, 1, toxicity?, 1, toxicity↓, 19, toxicity↑, 4, toxicity↝, 5, toxicity∅, 1, TumVol↓, 25, TumVol∅, 1, TumW↓, 14, TumW∅, 1, Weight∅, 1, Wound Healing↓, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1, GutMicro↑, 3, Sepsis↓, 2,
Total Targets: 1048

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4, antiOx↑, 49, Catalase↑, 18, Fenton↓, 1, GPx↑, 13, GPx1↑, 1, GSH↑, 13, GSR↑, 1, GSTs↑, 2, H2O2↓, 1, HDL↑, 2, HO-1?, 1, HO-1↓, 1, HO-1↑, 10, Iron∅, 1, Keap1↓, 2, lipid-P↓, 17, MDA↓, 12, MPO↓, 2, NOX↓, 1, NOX4↓, 1, NQO1↑, 1, NRF2↑, 22, RNS↓, 3, ROS↓, 44, ROS↑, 1, SOD↑, 16, SOD1↑, 2, SOD2↑, 1, TAC↑, 3, TBARS↓, 1, VitE↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1, compIII↑, 1, HSP60/HSPD1↓, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1, ALAT↓, 6, AMPK↓, 1, AMPK↑, 2, ATP↓, 1, ATP↑, 1, cytoP450↓, 1, glucose↓, 2, glucose↑, 1, glucose↝, 2, GlucoseCon↑, 2, HMG-CoA↓, 2, LDL↓, 3, NAD↓, 1, NADPH↓, 2, NADPH↑, 1, SIRT1↑, 2,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3, BAX↓, 3, Bcl-2↓, 1, Bcl-2↑, 1, Bcl-xL↑, 1, Casp12↓, 1, Casp3↓, 5, Casp9↓, 3, Cyt‑c↓, 1, Fas↓, 1, GranB/GZMB↓, 1, iNOS↓, 8, iNOS↑, 1, p38↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1, Akt↑, 4, p‑Akt↑, 1, ERK↓, 1, p‑ERK↑, 1, HGF/c-Met↑, 1, IKKα↑, 1, JAK2↑, 1, JNK↑, 2, p‑JNK↓, 1, MAPK↓, 4, MAPK↑, 2, mTOR↓, 2, mTOR↑, 2, PI3K↑, 4, PKCδ↓, 1, PKCδ↑, 1, STAT3↑, 2, p‑STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2, ATF4↓, 2, cMyc↓, 1, HDAC↓, 1, HOTAIR↑, 1, other↓, 2, other↑, 1, other↝, 4, tumCV↓, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2, CHOP/DDIT3↑, 1, p‑eIF2α↓, 1, ER Stress↓, 2, GRP78/BiP↓, 1, GRP78/BiP↑, 1, GRP94↑, 1, XBP-1↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 1, LC3II↓, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1, P53↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1, GADD34↓, 1, P21↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1, TumCP↓, 3,

Migration(tgid=13) ⓘ

AntiAg↑, 2, Ca+2↝, 1, EMT↑, 1, MMP9↓, 1, PAI-1/SERPINE1↓, 1, p‑Rac1↓, 1, TGF-β↓, 1, TGF-β↑, 1, TumCI↓, 2, TumCI∅, 1, TumCMig↓, 1, TumCMig∅, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1, E-sel↓, 1, Hif1a↓, 1, NO↓, 5, VEGF↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3, GastroP↑, 2, GLUT2↑, 2, GLUT3↑, 1, GLUT4↑, 1, IBI↑, 3, MMP↑, 2, MUC5AC↓, 1, VGSC↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1, CD25+↑, 1, CD4+↑, 2, COX2/PTGS2↓, 12, FOXP3↑, 1, HMGB1↓, 1, IFN-γ↓, 2, IL1↓, 2, IL10↓, 3, IL10↑, 3, IL12↓, 2, IL17↓, 1, IL1β↓, 7, IL4↓, 1, IL4↑, 1, IL6↓, 14, Imm↓, 1, Imm↑, 3, Inflam?, 1, Inflam↓, 55, Inflam↑, 2, IRF3↓, 1, LPS↓, 1, M2 MC↑, 1, MCP1/CCL2↓, 1, MyD88↓, 1, NF-kB↓, 13, NLRP3↓, 3, PGE2↓, 5, TLR2↓, 2, TLR4↓, 4, TNF-α↓, 14, Treg lymp↝, 1, TRIF↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, Ach↑, 1, AChE↓, 4, AChE↑, 1, BChE↓, 1, BDNF↓, 1, BDNF↑, 1, ChAT↑, 1, MAOA↓, 1, TPH1↓, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2, APP↓, 1, Aβ↓, 4, BACE/β-secretase↓, 1, tau↓, 1, p‑tau↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1, PPARγ↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 13, BioAv↑, 20, BioAv⇅, 1, BioAv↝, 9, BioEnh↑, 1, CompStab↑, 1, CompStab↝, 1, Dose↓, 1, Dose↑, 1, Dose↝, 7, eff↑, 5, Half-Life↓, 3, Half-Life↝, 2, Half-Life∅, 1, P-gp/ABCB1↓, 1, Synergy↑, 3,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6, ALP↓, 2, AST↓, 6, BMD↑, 2, BP↓, 1, BUN↓, 1, creat↓, 1, CRP↓, 3, IL6↓, 14, LDH↓, 2, SpO2↑, 1, TG/TAG↓, 1, Urea↓, 1,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1, AntiAge↑, 1, antiAll↑, 7, AntiArt↑, 3, AntiCan↑, 6, antiD↓, 1, AntiDiabetic↑, 8, antiPs↑, 1, AntiTum↓, 1, AntiTum↑, 2, cardioP↑, 19, chemoP↑, 1, chemoPv↑, 2, cognitive↑, 4, diuretic↑, 1, hepatoP↑, 17, memory↑, 3, neuroP?, 1, neuroP↑, 32, Obesity↓, 3, OS↑, 1, Pain↓, 2, radioP↑, 3, RenoP↑, 6, Risk↓, 1, Stroke↓, 3, toxicity↓, 22, toxicity↑, 2, toxicity↝, 6, toxicity∅, 7, Weight↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5, AntiFungal↑, 1, AntiP↑, 2, AntiViral↑, 6, Bacteria↓, 10, GutMicro↑, 9, Sepsis↓, 2,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,
Total Targets: 259

Scientific Paper Hit Count for: TumCI, Tumor Cell invasion

21 Curcumin
15 Resveratrol
14 Quercetin
13 Matrine
12 Honokiol
12 Magnolol
12 Shikonin
11 Berberine
11 Fisetin
10 Apigenin (mainly Parsley)
10 EGCG (Epigallocatechin Gallate)
10 Sulforaphane (mainly Broccoli)
9 Thymoquinone
8 Melatonin
8 Eugenol
8 Garcinol
8 Luteolin
7 Ashwagandha(Withaferin A)
7 Betulinic acid
7 Chlorogenic acid
7 Chrysin
7 Licochalcone A
7 Magnetic Fields
6 Metformin
6 Cinnamon
6 Dandelion Root
6 Emodin
6 Formononetin
6 Ginkgetin
6 Piperlongumine
5 Astragalus
5 Gemcitabine (Gemzar)
5 Ferulic acid
5 Hyperoside
5 Lycopene
5 Morin
5 Pterostilbene
4 Artemisinin
4 Baicalein
4 Carvacrol
4 Celastrol
4 Cyclopamine
4 Radiotherapy/Radiation
4 Gambogic Acid
4 Isoliquiritigenin
4 Juglone
4 Nimbolide
4 Phenethyl isothiocyanate
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
4 Urolithin
3 Silver-NanoParticles
3 Alpha-Lipoic-Acid
3 Berbamine
3 Brucea javanica
3 brusatol
3 Capsaicin
3 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
3 Centella asiatica / Gotu kola → asiaticoside
3 chaetocin
3 Zinc
3 Propolis -bee glue
3 Crocetin
3 Copper and Cu NanoParticles
3 Diindolylmethane
3 Evodiamine
3 Gallic acid
3 Paclitaxel/Taxol
3 Genistein (soy isoflavone)
3 Hydrogen Gas
3 Indole-3-carbinol
3 iodine
3 Magnetic Field Rotating
3 Bicarbonate(Sodium)
3 Piperine
3 Whole Body Vibration
2 alpha Linolenic acid
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Aspirin
2 Astaxanthin
2 Beta-Caryophyllene
2 Boron
2 Boswellia (frankincense)
2 α-Bisabolol / Chamomile oil
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Celecoxib
2 Hydroxycinnamic-acid
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Dasatinib/Phyrago
2 Deguelin
2 Disulfiram
2 Ellagic acid
2 Ginkgolic acids
2 Ginkgolide B
2 5-fluorouracil
2 Graviola
2 Grapeseed extract
2 Hibiscus sabdariffa
2 HydroxyTyrosol
2 isoflavones
2 isoorientin
2 isoquercitrin
2 itraconazole
2 Kaempferol
2 low dose naltrexone
2 Licorice
2 Linalool
2 Lutein
2 Modified Citrus Pectin
2 Mushroom Chaga, Inonotus obliquus
2 Marjoram (Origanum majorana)
2 Cisplatin
2 salinomycin
2 Sulfasalazine
2 Selenite (Sodium)
2 Aflavin-3,3′-digallate
2 Vitamin C (Ascorbic Acid)
1 1,8-Cineole
1 3-bromopyruvate
1 Ajoene (compound of Garlic)
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Ascorbyl Palmitate
1 Aloe anthraquinones
1 Biochanin A
1 Atorvastatin
1 bempedoic acid
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Butyrate
1 Carnosic acid
1 chitosan
1 Selenium NanoParticles
1 Chlorophyllin
1 Carvone
1 CUSP9
1 Cynaropicrin
1 Cysteamine
1 Dichloroacetate
1 Date Fruit Extract
1 Mistletoe/Viscum album Extracts
1 Ginkgo biloba-EGb 761
1 eicosapentaenoic acid
1 Sorafenib (brand name Nexavar)
1 Fucoidan
1 Galloflavin
1 Ginkgo biloba
1 Geraniol
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Proanthocyanidins
1 Hops (Humulus lupulus)
1 Isobavachalcone
1 phytic acid, Inositol hexakisphosphate
1 Ivermectin
1 Isovitexin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 mebendazole
1 Methyl Jasmonate
1 methylseleninic acid
1 Methyl salicylate / Sweet Birch oil
1 doxorubicin
1 immunotherapy
1 Magnesium
1 Methylsulfonylmethane
1 Noscapine
1 Oroxylin A
1 Oleuropein
1 Orlistat
1 Psoralidin
1 Docetaxel
1 Germacranolide sesquiterpene lactone
1 Rauwolfia serpentina/Indian Snakeroot
1 Salvia miltiorrhiza
1 Terpinen-4-ol / Tea Tree Oil
1 Thymol-Thymus vulgaris
1 Ursolic acid
1 Usnic acid
1 Arsenic trioxide
1 Vitamin K2
1 VitK3,menadione
1 Vitexin
1 β‐Elemene

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:324  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Home Page