TumCP Cancer Research Results

TumCP, Tumor Cell proliferation: Click to Expand ⟱
Source:
Type:
Tumor cell proliferation is a key characteristic of cancer. It refers to the rapid and uncontrolled growth of cells that can lead to the formation of tumors.
Scientific Papers found: Click to Expand⟱
6133- CHr,    Chrysin in PI3K/AKT and other apoptosis signalling pathways, and its effect on HeLa cells.
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, eff↑, CYP19↓, Hif1a↓, VEGF↓, NF-kB↓, PI3K↓, Akt↓,
6132- CHr,  MET,    Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression
- in-vitro, BC, T47D
Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, TumCP↓, Apoptosis↑, TumCI↓, TumMeta↓, angioG↓, selectivity↑,
6128- CHr,    Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential
- Review, Nor, NA - Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, AntiCan↑, *neuroP↑, *ROS↓, *BioAv↓, *BioAv↑, *cardioP↑, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *lipid-P↓, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *GSH↑, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *5HT↑, *Casp3↓, *Casp9↓, TumCCA↑, MAPK↓, PI3K↓, Akt↓, TumCP↓, TET1↑, TLR4↓, HER2/EBBR2↓, HK2↓, Glycolysis↓, glucose↓, lactateProd↓, ROS↑, mTOR↓, TumAuto↑, tumCV↓, ER Stress↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, BioAv↑,
2590- CHr,    Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway
- in-vitro, GBM, T98G - in-vitro, GBM, U251 - in-vitro, GBM, U87MG
TumCP↓, TumCMig↓, TumCI↓, NRF2↓, HO-1↓, NADPH↓, ERK↓,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, Synergy↑, Synergy↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, Synergy↑,
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2/PTGS2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
2787- CHr,    Network pharmacology unveils the intricate molecular landscape of Chrysin in breast cancer therapeutics
- Analysis, Var, MCF7
TumCP↓, angioG↓, TumCI↓, TumMeta↓, TP53↑, Akt↓, Casp3↑, tumCV↓, TNF-α↓, BioAv↑, BioAv↑, AKT1↓,
2791- CHr,    Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction
- in-vitro, Ovarian, OV90
TumCP↓, TumCD↑, ROS↑, Ca+2↑, MMP↓, MAPK↑, PI3K↑, p‑Akt↑, PCNA↓, p‑p70S6↑, p‑ERK↑, p38↑, JNK↑, DNAdam↑, TumCCA↑, chemoP↑,
1107- CHr,    Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway
- in-vitro, BC, NA
TumCP↓, Apoptosis↑, MMP-10↓, E-cadherin↑, Vim↓, Snail↓, Slug↓, EMT↓,
6628- Cic,    The Prevention and Treatment of Colorectal Cancer by Traditional Plants
- Review, CRC, NA
tumCV↓, Telomerase↓, Casp9↑, cl‑PARP↑, TumCP↓, β-catenin/ZEB1↓,
7039- Cic,    Chicoric acid targets PYGL to normalize glycogenolysis-driven glycolysis to suppress non-small cell lung cancer
- in-vitro, NSCLC, H1975 - in-vitro, NSCLC, H460
PYGL↓, Glycolysis↓, LDHA↓, lactateProd↓, GlucoseCon↓, TumCP↓,
6162- Cin,    Anticancer Potential and Molecular Mechanisms of Cinnamaldehyde and Its Congeners Present in the Cinnamon Plant
- Review, Var, NA
AntiCan↑, Apoptosis↑, ROS↑, BAX↑, Cyt‑c↑, Fas↑, Casp9↑, E-cadherin↑, Casp7↑, PARP↑, Bak↑, AMPK↑, Ca+2↑, BAD↑, MMP↓, cycA1/CCNA1↓, CycB/CCNB1↓, ERK↓, VEGF↓, TumCP↓, MAPK↓, mTOR↓, PI3K↓, PCNA↓, Bcl-2↓, TumCCA↑, angioG↓, *ROS↓, Inflam↓,
6164- Cin,    Advances in pharmacological effects and mechanism of action of cinnamaldehyde
- Review, Var, NA - Review, PSA, NA
*glucose↑, *cardioP↑, *Inflam↓, *lipid-P↓, GutMicro↑, TumCP↓, Apoptosis↑, TumCI↓, TumCMig↓, BAX↑, P53↑, Bcl-2↓, IAP1↓, PI3K↓, Akt↓, *ROS↓, *NRF2↑, *NF-kB↓, NF-kB↑,
6141- Cin,    The role and mechanism of cinnamaldehyde in cancer
- Review, Var, NA
Apoptosis↑, Casp↑, mtDam↑, angioG↓, TumCP↓, *Inflam↓, *antiOx↑, *ROS↓, *DNAdam↓, ROS↑, *Bcl-2↑, *BAX↓, *NF-kB↓, ChemoSen↑, ICAM-1↓, VCAM-1↓, PI3K↓, Akt↓, mTOR↓, BioAv↝,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, Synergy↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
1055- Cin,    Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1
- vitro+vivo, Melanoma, NA - vitro+vivo, CRC, NA - vitro+vivo, lymphoma, NA
TumCP↓, NF-kB↓, AP-1↓, Bcl-2↓, Bcl-xL↓, survivin↓,
1583- Citrate,    Extracellular citrate and metabolic adaptations of cancer cells
- Review, Var, NA
Warburg↓, OXPHOS↓, Dose∅, TumCP↓, ATP↓, ChemoSen↑, Apoptosis↑, TumCG↓, PFK1↓,
1580- Citrate,    Citrate activates autophagic death of prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway
- in-vitro, Pca, PC3 - in-vivo, PC, NA - in-vitro, Pca, LNCaP - in-vitro, Pca, WPMY-1
Apoptosis↑, Ca+2↓, Akt↓, mTOR↓, selectivity↑, TumCP↓, cl‑Casp3↑, cl‑PARP↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, ATG5↑, ATG7↑, Beclin-1/ATG6↑, TumAuto↑, CaMKII ↓,
1579- Citrate,    Effect of Food Additive Citric Acid on The Growth of Human Esophageal Carcinoma Cell Line EC109
- in-vitro, ESCC, Eca109
TumCP↓, e-LDH↑, MMP↓, Ca+2?, PFK↓, Glycolysis↓,
1578- Citrate,    Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update
- Review, Var, NA
TCA↑, FASN↑, Glycolysis↓, glucoNG↑, PFK1↓, PFK2↓, FBPase↑, TumCP↓, eff↑, ACLY↓, Dose↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, Bcl-xL↓, Mcl-1↓, IGF-1R↓, PI3K↓, Akt↓, mTOR↓, PTEN↑, ChemoSen↑, Dose?,
1577- Citrate,    Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high-fat diet
- in-vivo, PC, NA - in-vitro, PC, PANC1 - in-vitro, PC, PATU-8988 - in-vitro, PC, MIA PaCa-2
Apoptosis↑, TumCP↓, TumCG↑, SPARC↑, Glycolysis↓, OCR↓, pol-M1↑, pol-M2 MC↓, Weight∅, ATP↓, ECAR↓, mitResp↓, i-ATP↑, p65↓, i-Ca+2↑, eff↓,
6146- Citrate,    Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high‐fat diet
- in-vitro, PC, NA
Apoptosis↑, TumCP↓, TumCG↓, SPARC↑, Glycolysis↓, OCR↓, ATP↓, NF-kB↓, Ca+2↑,
4762- CoQ10,    The role of coenzyme Q10 as a preventive and therapeutic agent for the treatment of cancers
- Review, Var, NA
*AntiCan↓, *ROS↓, chemoPv↑, TumCCA↑, Apoptosis↑, TumCP↓, angioG↓, MMPs↓, ChemoSen∅,
4772- CoQ10,    The anti-tumor activities of coenzyme Q0 through ROS-mediated autophagic cell death in human triple-negative breast cells
- in-vitro, BC, MDA-MB-468 - in-vitro, BC, MDA-MB-231
TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, LC3II↑, eff↓, TumCG↓, Bax:Bcl2↑, Beclin-1/ATG6↑, TumAuto↑, ROS↑,
6372- CPLE,    Anti-proliferation and Apoptosis Induction of Aqueous Leaf Extract of Carica papaya L. on Human Breast Cancer Cells MCF-7
- in-vitro, BC, MCF7
TumCP↓, Apoptosis↑,
6373- CPLE,    Anticancer Activity of Phytochemicals of the Papaya Plant Assessed: A Narrative Review
- Review, Var, NA
chemoPv↑, TumCP↓, angioG↓, TumMeta↓, ROS↑, Dose↝,
5810- CPT,  CPT-11,    Camptothein-Based Anti-Cancer Therapies and Strategies to Improve Their Therapeutic Index
- Review, Var, NA
AntiCan↑, BioAv↓, toxicity⇅, TOP1↓, Apoptosis↑, TumCP↓, other↝, BioAv↑, other↝, eff↑,
9272- CRAN,    Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents
- Review, Var, NA
TumCD↑, Apoptosis↑, necrosis↑, TumAuto↑, TumCP↓, ROS↝, tumCV↓, lipid-P↓, TNF-α↓, IL6↓, ROS↓, TumCCA↑, ROS↑, H2O2↑, PI3K↓, Akt↓, mTOR↓, Ingr↝,
6179- Cro,    Crocetin suppresses the growth and migration in HCT-116 human colorectal cancer cells by activating the p-38 MAPK signaling pathway
- in-vitro, CRC, HCT116
TumCMig↓, VEGF↓, MMP9↓, p‑p38↑, TumCP↓,
6178- Cro,    Exploring the therapeutic efficacy of crocetin in oncology: an evidence-based review
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, ChemoSen↑,
6291- Cro,    Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model
- vitro+vivo, PC, MIA PaCa-2 - vitro+vivo, PC, Bxpc-3 - vitro+vivo, PC, Capan1 - vitro+vivo, PC, AsPC-1
TumCG↓, EGFR↓, Apoptosis↑, Bax:Bcl2↑, TumCP↓, TumCCA↑, Dose↝,
6314- Cro,    Crocin promotes ferroptosis in gastric cancer via the Nrf2/GGTLC2 pathway
- in-vitro, GC, NA
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↓, antiOx↓, Ferroptosis↑, NRF2↑, P53↑, TumCCA↑, ChemoSen↑, EMT↓, Hif1a↓, ROS↑,
6309- Cro,    Crocin exerts anti-tumor effect in colon cancer cells via repressing the JaK pathway
- in-vitro, CRC, HCT116
tumCV↓, TumCP↓, Ki-67↓, Apoptosis↓, Inflam↓, ROS↑, MMP↓, JAK2↓, STAT3↓, ERK↓, MIP2↓, IL6↓, MCP1/CCL2↓, IL8↓, IL1β↓, TNF-α↓, SOD↓, Catalase↓, GSH↓, ROS↑, mtDam↑,
6308- Cro,    Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage
- vitro+vivo, PC, Bxpc-3
Bcl-2↓, Apoptosis↑, Cyt‑c↑, TumCG↓, radioP↑, TumCCA↑, TumCP↓, DNAdam↑, TBARS↓, P53↑, p38↑, CDK2↓, cMyc↓, *MDA↓, GSH↑,
6306- Cro,    Crocetin induces apoptosis of BGC-823 human gastric cancer cells
- in-vitro, GC, BGC-823
TumCP↓, MMP↓, Casp3↑, Cyt‑c↑,
6304- Cro,    Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ
- in-vitro, BC, NA
NF-kB↓, tumCV↓, TumCP↓, TNF-α↓, IL1β↓, Inflam↓, PRKCQ/PKCθ↓,
6294- Cro,    Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention
- Review, Var, NA
*chemoPv↑, *antiOx↑, Apoptosis↑, TumCP↓, Diff↑, TumCCA↑, TumCG↓, TOP2↓, hTERT/TERT↓, Inflam↓, IL1β↓, TNF-α↓, Casp8↑, BAX↑, Cyt‑c↑, ChemoSen↑, RadioS↑, Apoptosis↑, cycD1/CCND1↓, P21↑, p27/CDKN1B↑, Bcl-2↓, Bax:Bcl2↑, Casp9↑, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, N-cadherin↓,
6293- Cro,    Crocetin: an agent derived from saffron for prevention and therapy for cancer
- Review, Var, NA
*toxicity↓, *lipid-P↓, *neuroP↑, *BloodF↑, *BP↓, *RenoP↑, *ATP↑, AntiCan↑, TumCP↓, Apoptosis↑, lipid-P↓, ROS↓, GSTs↑, Catalase↑, SOD↑,
6292- Cro,    Crocetin induces cytotoxicity and enhances vincristine-induced cancer cell death via p53-dependent and -independent mechanisms
- in-vitro, Cerv, HeLa - in-vitro, Lung, A549 - in-vitro, Ovarian, SKOV3
TumCP↓, TumCCA↑, P21↑, Apoptosis↑, eff↑,
6521- CRV,    L-carvone induces p53, caspase 3 mediated apoptosis and inhibits the migration of breast cancer cell lines
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, Apoptosis↑, TumCCA↑, DNAdam↑, ROS↑, GSH↑, P53↑, BAD↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑,
6520- CRV,    Health Benefits and Pharmacological Properties of Carvone
- Review, Nor, NA
*Bacteria↓, *AntiFungal↑, *antiOx↑, *Inflam↓, AntiCan↑, *AntiDiabetic↑, *Obesity↓, TumCCA↑, *AntiArt↑, Imm↑, *P450↓, *GSR↑, GSTs↑, GSH↑, BAX↑, Casp3↑, TumCP↓, TumCMig↓, Apoptosis↑,
6523- CRV,    Anticancer effects of Carvone in myeloma cells is mediated through the inhibition of p38 MAPK signalling pathway, apoptosis induction and inhibition of cell invasion
- in-vitro, Melanoma, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, TumCI↓, p‑p38↓,
6526- CRV,    Multi-targeted effects of D-carvone against Non-Small Cell Lung Cancer (NSCLC): A network pharmacology-based study
- Review, NSCLC, NA
TumCP↓, Wound Healing↓, Apoptosis↓,
6528- CRV,    D-carvone inhibits growth, migration, cell cycle at G0/G1 phase and induces apoptosis in A431 cells by disrupting mitochondrial membrane potential
- in-vitro, Melanoma, A431
Apoptosis↑, ROS↑, MMP↓, TumCCA↑, TumCP↓,
6530- CRV,    Monoterpenes as Anticancer Therapeutic Agents
- Review, Var, NA
selectivity↑, TumCP↓, Apoptosis↑, TumCCA↑, tumCV↓,
7412- CS,  Chemo,    Artichoke Polyphenols Sensitize Human Breast Cancer Cells to Chemotherapeutic Drugs via a ROS-Mediated Downregulation of Flap Endonuclease 1
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Apoptosis↑, ROS↑, TumCP↓, DNAdam↑, FEN1↓, ChemoSen↑, NRF2↑,
7425- CS,    Artichoke as a melanoma growth inhibitor
- in-vitro, Melanoma, NA
AntiCan↑, tumCV↓, PCNA↓, Casp3↑, P21↑, p27/CDKN1B↑, CDK4↓, survivin↓, TumCP↓, Apoptosis↑,
6182- Cu,    Role of cuproptosis in digestive system tumors (Review)
- Review, Var, NA
Cupro↑, TumCG↓, Apoptosis↑, ROS↑, Ferroptosis↑, ETC↓, MMP↓, Ca+2↑, Fenton↑, lipid-P↑, MPT↑, ATP↓, Cyt‑c↑, Casp↑, angioG↑, TumCP↑, TumCMig↑, TumCI↑, TumMeta↑, DDS↑, eff↑,
6189- Cuc,    Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells
- in-vitro, Lung, A549
TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, Cyt‑c↑, STAT3↓, Casp3↑, Casp9↑, MMP↓,
6192- Cuc,    Cucurbitacin B and I inhibits colon cancer growth by targeting the Notch signaling pathway
- vitro+vivo, CRC, NA
TumCP↓, TumCCA↑, CD44↓, CSCs↓, NOTCH↓,

Showing Research Papers: 301 to 350 of 1302
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1302

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 2,   NA↑, 4,   NA↝, 1,   NA?, 1,   NA∅, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 2,   antiOx↓, 5,   antiOx↑, 25,   antiOx⇅, 2,   ARE↑, 1,   ARE/EpRE↑, 1,   Catalase↓, 9,   Catalase↑, 7,   DJ-1↓, 1,   ENOX2↑, 1,   Fenton↑, 4,   GCLC↑, 2,   GPx↓, 4,   GPx↑, 7,   GPx1↓, 1,   GPx4↓, 30,   GPx4↑, 2,   GSH↓, 60,   GSH↑, 12,   GSH/GSSG↓, 10,   GSR↓, 1,   GSR↑, 3,   GSSG↑, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 5,   H2O2↓, 3,   H2O2↑, 8,   mt-H2O2↑, 1,   HO-1↓, 9,   HO-1↑, 22,   HO-2↓, 1,   Iron↓, 3,   Iron↑, 19,   i-Iron↑, 5,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 2,   lipid-P↓, 10,   lipid-P↑, 41,   lipid-P↝, 1,   MDA↓, 4,   MDA↑, 20,   i-MDA↑, 2,   MPO↓, 1,   NADH↓, 2,   mt-NADH↑, 1,   NQO1?, 1,   NQO1↓, 1,   NQO1↑, 6,   Nrf1↑, 1,   NRF2↓, 27,   NRF2↑, 33,   NRF2↝, 1,   Prx↓, 1,   Prx3↑, 1,   Prx6↑, 1,   PrxII↓, 2,   RNS↑, 1,   ROS?, 3,   ROS↓, 38,   ROS↑, 412,   ROS⇅, 9,   ROS↝, 6,   ROS∅, 1,   i-ROS↑, 2,   mt-ROS↓, 2,   mt-ROS↑, 15,   selenoP↓, 1,   SOD↓, 13,   SOD↑, 11,   SOD1↓, 4,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 4,   mt-SOD2↑, 1,   TAC↓, 1,   TBARS↓, 1,   Thiols↓, 2,   i-Thiols↓, 1,   TKT↓, 1,   TKT↝, 1,   Trx↓, 3,   Trx↑, 1,   Trx1↓, 1,   Trx1↑, 1,   ox-Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 9,   TrxR1↓, 5,   TrxR1↑, 1,   xCT/SLC7A11↓, 10,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↝, 1,   FTH1↓, 5,   IronCh↑, 4,   LIP↑, 1,   NCOA4↑, 2,   SFXN2↓, 1,   Tf↑, 2,   TfR1/CD71↓, 1,   TfR1/CD71↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   BCR-ABL↓, 1,   CDC2↓, 5,   CDC25↓, 15,   CDC25↝, 1,   compI↓, 6,   compII↓, 1,   compIII↓, 3,   compV↓, 1,   EGF↓, 4,   ETC↓, 6,   HSP60/HSPD1↓, 2,   Insulin↓, 3,   KIF2C↓, 1,   mitResp↓, 6,   mitResp↑, 1,   MKK7↓, 2,   Mortalin↓, 1,   mtDam?, 1,   mtDam↑, 40,   OCR↓, 13,   OCR↑, 7,   mt-OCR↑, 1,   OXPHOS↓, 6,   OXPHOS↑, 10,   mt-OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 4,   PDH↝, 1,   PDH∅, 1,   PGC-1α↑, 2,   PHB↓, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 2,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 4,   5-HETE↓, 1,   5LO↓, 3,   ACC↓, 4,   ACC↑, 3,   p‑ACC↑, 1,   ACLY↓, 3,   ACOX1↑, 1,   ACSL1↓, 1,   ACSL4↑, 6,   ALAT↓, 5,   ALAT↑, 1,   ALDOA↓, 2,   ALDOB↑, 1,   AMP↑, 3,   AMPK?, 1,   AMPK↓, 2,   AMPK↑, 42,   p‑AMPK↑, 6,   ATP↓, 47,   ATP↑, 3,   e-ATP↑, 1,   i-ATP↓, 1,   i-ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 5,   CAIX/CA9↑, 1,   CBS↑, 1,   CPT1A↓, 1,   CPT1A↑, 1,   DGAT1↓, 1,   ECAR↓, 8,   ECAR↑, 1,   ECAR↝, 1,   ENO1↓, 3,   ENO3↑, 1,   FABP4↓, 1,   FAO↓, 1,   FASN↓, 12,   FASN↑, 1,   FBI-1↓, 1,   FBP1↑, 1,   FBPase↑, 1,   FDG↓, 1,   G6PD↓, 2,   GALNT10↓, 1,   GLO-I↓, 1,   GLS↓, 3,   glucoNG↓, 1,   glucoNG↑, 1,   glucose↓, 6,   GlucoseCon↓, 34,   glut↓, 1,   GlutaM↓, 1,   GlutMet↓, 3,   Glycolysis↓, 84,   Glycolysis↑, 1,   Glycolysis↝, 1,   GPI↓, 1,   GSK‐3β↓, 13,   GSK‐3β↑, 9,   p‑GSK‐3β↓, 7,   H2S↑, 1,   ac‑Histones↑, 1,   HK1↓, 2,   HK2↓, 39,   HK3↑, 1,   HMG-CoA↓, 6,   HSD17B4↓, 1,   IDH1↓, 1,   lactateProd↓, 40,   lactateProd↑, 1,   LDHA↓, 19,   LDHA∅, 1,   LDL↓, 4,   LDL↑, 1,   lipidLev↓, 2,   lipoGen↓, 2,   MCT4↓, 1,   NAD↓, 1,   NADPH↓, 6,   O-Glc↓, 1,   PCK1↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 15,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 1,   PFK↓, 10,   PFK1↓, 6,   PFK2↓, 1,   PFKFB3↓, 2,   PFKFB4?, 1,   PGC1A↑, 1,   PGK1↓, 2,   PGK2↑, 1,   PGM1↓, 1,   PGM1↑, 1,   PGM3↑, 1,   PIP3↑, 1,   PKLR↑, 1,   PKM1↑, 1,   PKM2↓, 37,   PKM2↑, 1,   PKM2∅, 2,   p‑PKM2↓, 1,   polyA↓, 1,   PPP↓, 3,   PYGL↓, 1,   Pyrim↓, 1,   R5P↝, 1,   p‑S6↓, 2,   SCD1↓, 4,   SCP2↓, 1,   SIRT1↓, 8,   SIRT1↑, 10,   SIRT2↓, 1,   SIRT2↑, 1,   SREBF2↓, 1,   SREBP1/SREBF1↓, 6,   SREBP2↓, 2,   TCA↓, 2,   TCA↑, 2,   TPI↓, 1,   TS↓, 3,   TumCM/A↓, 1,   UGDH↓, 2,   Warburg↓, 25,  

Cell Death(tgid=5) ⓘ

AIF↑, 12,   APAF1↑, 9,   Apoptosis?, 6,   Apoptosis↓, 20,   Apoptosis↑, 647,   mt-Apoptosis↑, 4,   ASC↑, 1,   BAD?, 1,   BAD↓, 3,   BAD↑, 19,   p‑BAD↓, 1,   Bak↑, 10,   BAX↓, 6,   BAX↑, 210,   BAX⇅, 1,   BAX↝, 1,   Bax:Bcl2↑, 41,   Bcl-2↓, 223,   Bcl-2↑, 6,   Bcl-2↝, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 46,   Bcl-xL↑, 2,   BID↓, 1,   BID↑, 6,   BIM↑, 7,   BNIP3↑, 2,   BOK↑, 1,   Casp↓, 3,   Casp↑, 53,   Casp↝, 2,   cl‑Casp↑, 3,   Casp1↑, 1,   cl‑Casp1↑, 1,   Casp10↑, 2,   Casp10∅, 1,   Casp12↑, 3,   Casp12↝, 1,   cl‑Casp12↑, 2,   cl‑Casp12↝, 1,   Casp2↑, 3,   Casp3↓, 7,   Casp3↑, 205,   Casp3↝, 2,   cl‑Casp3↓, 1,   cl‑Casp3↑, 84,   proCasp3↓, 1,   proCasp3↑, 3,   CASP4↑, 1,   Casp6↑, 1,   Casp7↓, 1,   Casp7↑, 27,   cl‑Casp7↑, 4,   Casp8↓, 1,   Casp8↑, 44,   Casp8∅, 1,   cl‑Casp8↑, 9,   proCasp8↓, 1,   proCasp8↑, 3,   Casp9↑, 106,   p‑Casp9↑, 1,   cl‑Casp9↓, 1,   cl‑Casp9↑, 22,   proCasp9↓, 1,   proCasp9↑, 2,   cFLIP↓, 1,   Cupro↑, 1,   Cyt‑c↑, 104,   Cyt‑c↝, 3,   mt-Cyt‑c↓, 1,   Diablo↑, 5,   DIDO1/DIO-1↑, 1,   DR5↑, 21,   DR5∅, 1,   Endon↑, 4,   FADD↑, 8,   FADD∅, 1,   Fas↓, 2,   Fas↑, 21,   FasL↓, 1,   FasL↑, 7,   FasL⇅, 1,   Ferroptosis↓, 2,   Ferroptosis↑, 47,   GranB/GZMB↑, 1,   GRP58↓, 1,   GSDMD↑, 2,   cl‑GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 11,   IAP1↑, 1,   IAP2/BIRC3↓, 2,   ICAD↓, 1,   ICAD↑, 1,   ICD↑, 2,   iNOS↓, 16,   Mcl-1↓, 29,   MDM2↓, 15,   p‑MDM2↓, 1,   MLKL↑, 1,   MOMP↑, 2,   NAIP↓, 1,   Necroptosis↑, 8,   necrosis↑, 4,   NOXA↑, 4,   p38↓, 4,   p38↑, 26,   p‑p38↓, 4,   p‑p38↑, 8,   Paraptosis↑, 1,   Perforin↑, 1,   PUMA↓, 1,   PUMA↑, 7,   Pyro↑, 4,   RIP3↓, 1,   RIP3↑, 2,   p‑RIP3↑, 1,   survivin↓, 72,   TNFR 1↓, 1,   TNFR 1↑, 2,   TRAIL↑, 3,   TRAIL⇅, 1,   TRAILR↑, 3,   TumCD?, 1,   TumCD↓, 2,   TumCD↑, 36,   TumCD∅, 2,   TUNEL↑, 2,   XIAP↓, 31,   YAP/TEAD↓, 12,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 239,   Akt↑, 9,   Akt↝, 1,   p‑Akt↓, 85,   p‑Akt↑, 2,   AKT1↓, 7,   Akt2↓, 3,   AKT3↓, 1,   AMPKα↓, 1,   AMPKα↑, 1,   BCAP↓, 1,   BRAF↓, 1,   CaMKII ↓, 3,   Cavin3↓, 1,   CIP2A↓, 2,   CK2↓, 3,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 2,   CREB2↓, 1,   cSrc↓, 3,   DDIT4↑, 1,   EGFR↓, 42,   p‑EGFR↓, 4,   ERK↓, 71,   ERK↑, 9,   ERK↝, 1,   p‑ERK↓, 28,   p‑ERK↑, 6,   FGFR1↓, 2,   FGFR2↓, 1,   FGFR4/CD334↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 13,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↓, 1,   IGF-1R↓, 10,   IGF-2R↑, 1,   IGFR↓, 4,   IKKα↓, 10,   IKKα↑, 3,   p‑IKKα↓, 2,   ILK↓, 1,   IR↓, 2,   IκB↓, 1,   JAK↓, 11,   JAK1↓, 9,   JAK1↑, 1,   JAK2↓, 23,   p‑JAK2↓, 2,   JNK↓, 6,   JNK↑, 30,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 7,   cl‑JNK↑, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 49,   MAPK↑, 23,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 4,   MARK4↓, 2,   MEK↓, 7,   p‑MEK↓, 3,   p‑MEK↑, 1,   MKK4↓, 1,   mTOR?, 1,   mTOR↓, 124,   mTOR↑, 6,   mTOR⇅, 1,   p‑mTOR↓, 20,   mTORC2↓, 1,   mTORC2↑, 1,   p42↑, 1,   p70S6↓, 2,   p70S6↑, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 7,   p‑P70S6K↓, 3,   p85S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PFKFB2↓, 1,   PHKG1↑, 1,   PI3K?, 1,   PI3K↓, 168,   PI3K↑, 3,   PI3K↝, 1,   p‑PI3K↓, 23,   PI3K/Akt↓, 6,   PI3k/Akt/mTOR↓, 1,   PI3K/mTOR/ETS2↓, 1,   PKA↓, 4,   PKCδ↓, 14,   PP2A↑, 1,   PRAS40↓, 1,   PRAS40↑, 1,   PRKCQ/PKCθ↓, 1,   PTEN↓, 3,   PTEN↑, 29,   Raf↓, 6,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 13,   RIP1↓, 2,   RIP1↑, 1,   S6K↓, 1,   p‑S6K↓, 1,   SGK1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 15,   Src↓, 3,   p‑Src↓, 2,   STAT↓, 8,   p‑STAT↓, 1,   STAT3↓, 94,   STAT3↑, 6,   STAT3↝, 1,   p‑STAT3↓, 23,   p‑STAT3↑, 2,   mt-STAT3↓, 1,   STAT4↓, 1,   STAT5↓, 3,   STAT6↓, 2,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF2↓, 2,   ATF3↑, 2,   ATF4↑, 14,   p‑ATF4↝, 1,   BRD4↓, 1,   CBP↓, 2,   CBP↑, 1,   ChrMod↑, 1,   cJun↓, 5,   cJun↑, 2,   p‑cJun↓, 1,   p‑cJun↑, 2,   cMyc↓, 54,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 6,   DNMT1↑, 1,   DNMT3A↓, 1,   DNMT3B↓, 2,   DNMTs↓, 7,   EZH2↓, 3,   FOXM1↓, 5,   FOXO↑, 2,   FOXO1↓, 3,   FOXO1↑, 4,   FOXO3↓, 2,   FOXO3↑, 4,   p‑FOXO3↓, 1,   FOXO4↓, 2,   FOXO4↑, 1,   GATA2↑, 1,   GATA3↓, 1,   H3↓, 2,   H3↑, 1,   p‑H3↑, 1,   ac‑H3↑, 3,   ac‑H3↝, 1,   H3K18↓, 1,   H3K27ac∅, 1,   H3K9↓, 2,   H4↑, 2,   ac‑H4↑, 1,   ac‑H4∅, 1,   HATs↓, 4,   HATs↑, 1,   HDAC↓, 25,   HDAC1↓, 6,   HDAC2↓, 3,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC6↓, 2,   HDAC8↓, 1,   HES1↓, 3,   HMTs↓, 1,   HOXB-AS1↓, 1,   IGF2BP3/IMP3/KOC↓, 1,   JPT1/HN1↓, 1,   KISS1↑, 1,   LINC01116↓, 1,   miR-106b↓, 2,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-122-5p↑, 1,   miR-124-3p↓, 1,   miR-130a↓, 3,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-143↑, 1,   miR-145↑, 1,   miR-148a↓, 1,   miR-149↑, 1,   miR-155↓, 3,   miR-182-5p↓, 1,   miR-192-5p↑, 1,   miR-19b↓, 2,   miR-205↑, 1,   miR-21↓, 12,   miR-21↝, 1,   miR-215-5p↑, 1,   miR-218↑, 1,   miR-22↑, 2,   miR-221↓, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-320a↓, 1,   miR-339-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↑, 6,   miR-375↓, 1,   miR-375↑, 2,   miR-384↑, 1,   miR-422a↑, 2,   miR-486↑, 1,   miR-490↑, 1,   miR-590-3p↑, 1,   miR-592↑, 1,   miR-99↑, 1,   MTA2↓, 1,   Myc↓, 5,   Myc↑, 1,   MYCN↓, 1,   MYCN↑, 1,   n-MYC↓, 1,   NDRG1↑, 1,   NNMT↓, 1,   OCT4↓, 11,   OLIG2↓, 1,   other?, 1,   other↓, 5,   other↑, 12,   other↝, 38,   other∅, 1,   PAX2↓, 1,   PCAF↓, 1,   SD↑, 1,   SOX2↓, 10,   SOX4↓, 1,   SOX9↓, 1,   SUV39H↓, 5,   TBX15↑, 1,   TFAP2A↓, 1,   TFE3↑, 1,   TLE1↓, 1,   tumCV↓, 115,   tumCV↑, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 5,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 26,   p‑CHOP/DDIT3↝, 1,   CRT↑, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 8,   p‑eIF2α↑, 5,   p‑eIF2α↝, 1,   ER Stress↓, 1,   ER Stress↑, 53,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 15,   GRP94↑, 1,   HSF1↓, 1,   HSP27↓, 3,   HSP27↑, 1,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 5,   e-HSP70/HSPA5↓, 1,   HSP90↓, 21,   HSP90↑, 2,   HTRA↓, 1,   IRE1↓, 1,   IRE1↑, 3,   IRE1∅, 1,   p‑IRE1↑, 1,   NQO2↑, 1,   OTUB2↓, 1,   PDI↑, 2,   PERK↑, 13,   p‑PERK↝, 1,   Proteasome↓, 3,   SERPINH1/HSP47↓, 1,   UPR↓, 1,   UPR↑, 10,   mt-UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 2,   ATG16L1↑, 1,   ATG3↓, 1,   ATG3↑, 3,   ATG5↓, 1,   ATG5↑, 10,   ATG7↑, 5,   autolysosome↑, 1,   Beclin-1/ATG6↓, 8,   Beclin-1/ATG6↑, 30,   CTSB↓, 2,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 7,   LC3B↓, 1,   LC3B↑, 3,   LC3B-II↓, 1,   LC3B-II↑, 7,   LC3I↓, 1,   LC3II↓, 2,   LC3II↑, 19,   LC3s↓, 1,   LC3s↑, 2,   lysoMP↑, 2,   MitoP↓, 1,   p62↓, 13,   p62↑, 7,   PARK2↑, 1,   RUBCN↓, 1,   SESN2↑, 2,   TumAuto?, 1,   TumAuto↓, 4,   TumAuto↑, 99,   TumAuto⇅, 1,   TumAuto↝, 2,   mt-TumAuto↑, 1,   ULK1/ATG1↑, 1,   p‑ULK1/ATG1↑, 1,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   ATM↓, 1,   ATM↑, 4,   p‑ATM↑, 1,   ATR↑, 4,   BRCA1↓, 3,   BRCA2↓, 1,   DNAdam↓, 5,   DNAdam↑, 95,   DNArepair↓, 5,   DNArepair↑, 3,   ERCC1↓, 2,   ERCC3↑, 1,   ERCC4/XPF↓, 1,   m-FAM72A↓, 1,   FEN1↓, 2,   hTERT/TERT↓, 13,   Ku70/XRCC6↓, 1,   NHEJ↓, 1,   NKX3.1↑, 1,   P53?, 2,   P53↓, 6,   P53↑, 128,   P53⇅, 1,   P53↝, 4,   p‑P53↓, 1,   p‑P53↑, 6,   p53 Wildtype↓, 1,   PARP↓, 3,   PARP↑, 24,   PARP↝, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 111,   PARP1↑, 4,   cl‑PARP1↑, 3,   PCNA↓, 44,   PCNA↑, 1,   PCNA↝, 1,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 2,   SIRT6↑, 1,   SMG1↑, 1,   Telomerase↓, 13,   TOP1↓, 6,   TOP2↓, 6,   TOP2↑, 1,   TP53↓, 1,   TP53↑, 3,   TRF2↓, 2,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 17,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

AURKB↓, 1,   BRD4↓, 1,   CC(CDKs/cyclins)↓, 2,   CDK1↓, 27,   CDK1↑, 5,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 53,   CDK2↑, 6,   CDK4↓, 61,   CDK4↑, 3,   CDK4∅, 1,   CDK4/6↓, 1,   CDK6↓, 19,   CDK6↑, 3,   CDK6∅, 1,   CDK7↓, 1,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN2C/p18↑, 1,   CHK1↓, 3,   CHK1↑, 4,   CHK1↝, 1,   p‑CHK1↓, 1,   p‑CHK1↑, 1,   Chk2↓, 3,   Chk2↑, 4,   p‑Chk2↑, 1,   Cyc↓, 4,   cycA1/CCNA1↓, 16,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 40,   CycB/CCNB1↑, 6,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 144,   cycD1/CCND1↑, 4,   cycD1/CCND1↝, 1,   cycD1/CCND1∅, 1,   CycD3↓, 4,   cycE/CCNE↓, 33,   cycE/CCNE↑, 3,   cycE/CCNE↝, 1,   cycE1↓, 1,   E2F4↑, 1,   E2Fs↓, 7,   E2Fs↑, 1,   FBXO5/EMI1↓, 1,   GADD34↑, 1,   GADD45A↓, 1,   GADD45A↑, 5,   Ki-67↓, 65,   MAD↓, 1,   mitA↑, 4,   MKI67↑, 1,   p19↑, 1,   P21↓, 5,   P21↑, 113,   P21↝, 1,   p‑P21↑, 1,   p27/CDKN1B↓, 5,   p27/CDKN1B↑, 35,   cl‑p27/CDKN1B↓, 1,   PLK1↓, 1,   pRB↓, 4,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 2,   RRM2↓, 1,   TAp63α↑, 1,   TumCCA?, 3,   TumCCA↓, 13,   TumCCA↑, 418,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   ALDH↓, 5,   ALDH1A1↓, 4,   ALDH1A3↓, 1,   AXIN1↓, 1,   AXIN1↑, 3,   BMI1↓, 2,   BMP7/OP1↓, 2,   CD133↓, 15,   CD24↓, 6,   CD34↓, 2,   cFos↓, 7,   cMYB↓, 1,   CSCs?, 1,   CSCs↓, 62,   CSCs↑, 3,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 11,   EIF4E↓, 1,   EP2↓, 1,   EP4/PTGER4↓, 2,   FGF↓, 3,   GH↓, 1,   Gli1↓, 14,   HH?, 1,   HH↓, 22,   HMGCR↓, 2,   IGF-1↓, 10,   IGF-1↑, 1,   IGF-2↓, 1,   IGF-2↑, 1,   IGFBP1↑, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Jun↓, 2,   Ki-67↓, 65,   Let-7↑, 3,   LRP6↓, 2,   MCM2↓, 1,   mTORC1↓, 4,   Nanog↓, 11,   Nestin↓, 1,   NICD↓, 1,   NKD2↑, 2,   NOTCH↓, 14,   NOTCH↑, 2,   NOTCH1↓, 11,   NOTCH1↑, 1,   NOTCH1↝, 1,   NOTCH2↓, 1,   NOTCH3↓, 3,   OGF↑, 1,   OGFr↑, 4,   p300↓, 3,   PCLAF↓, 1,   Piezo1↑, 1,   circ‑PLEKHM3↑, 1,   PTCH1↓, 2,   SCF↓, 1,   Shh↓, 10,   Smo↓, 6,   Smo∅, 1,   TAZ↓, 2,   TumCG?, 3,   TumCG↓, 213,   TumCG↑, 7,   TumCG↝, 1,   TumCG∅, 1,   TumCP?, 6,   TumCP↓, 1259,   TumCP↑, 26,   TumCP⇅, 6,   TumCP∅, 5,   p‑TumCP↓, 1,   tyrosinase↓, 2,   WDR72↓, 1,   Wnt↓, 57,   Wnt/(β-catenin)↓, 9,   ZFX↓, 2,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AGRN↓, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↑, 1,   AP-1↓, 12,   AP-1↝, 1,   ASAP2↓, 1,   ATPase↓, 2,   AXL↓, 2,   BACH1↓, 1,   BACH1↑, 1,   Ca+2?, 1,   Ca+2↓, 3,   Ca+2↑, 36,   Ca+2↝, 2,   i-Ca+2↑, 3,   CAFs/TAFs↓, 1,   cal2↑, 2,   CCAT1↓, 2,   CCN2/CTGF↓, 3,   CD11b↑, 1,   CD38↓, 1,   CD38↑, 1,   Cdc42↓, 1,   Cdc42↑, 1,   Chl↑, 1,   Cofilin↓, 2,   COL1A1↓, 1,   COL3A1↓, 1,   COL4A3↓, 1,   E-cadherin↓, 10,   E-cadherin↑, 62,   E-cadherin↝, 1,   EMT?, 1,   EMT↓, 117,   EMT↑, 2,   EpCAM↓, 2,   F-actin↓, 3,   FAK↓, 13,   FAK↑, 2,   p‑FAK↓, 5,   Fibronectin↓, 5,   Furin↓, 1,   GLI2↓, 4,   GLI3↑, 1,   IQGAP3↓, 1,   ITGA5↓, 1,   ITGB1↓, 3,   ITGB4↓, 1,   ITGB6↓, 1,   KRAS↓, 1,   LAMs↓, 2,   LEF1↓, 1,   LIMK2↓, 1,   MALAT1↓, 2,   MET↓, 2,   MET↑, 1,   MMP-10↓, 2,   MMP1↓, 4,   MMP13↓, 4,   MMP14↓, 1,   MMP16↓, 2,   MMP17↓, 1,   MMP2↓, 102,   proMMP2↓, 1,   MMP3↓, 8,   MMP7↓, 7,   MMP9↓, 139,   MMP9↑, 2,   MMPs↓, 31,   MMPs↝, 1,   MTA1↓, 1,   MUC1↓, 1,   MUC4↓, 1,   N-cadherin↓, 42,   N-cadherin↑, 1,   N-cadherin↝, 1,   NCAM↓, 1,   NEDD9↓, 1,   p44↓, 1,   p44↑, 1,   p‑p44↓, 1,   PAK1↓, 3,   pax↓, 2,   PCBP1↓, 1,   PDGF↓, 6,   Rac1↓, 2,   RHBDD1↓, 1,   Rho↓, 5,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 16,   Smad1↓, 1,   Smad1↑, 1,   Smad1↝, 1,   SMAD2↓, 2,   p‑SMAD2↓, 5,   SMAD3↓, 5,   SMAD3↑, 1,   p‑SMAD3↓, 3,   SMAD4↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 32,   Snail↑, 1,   SPARC↑, 2,   STAC2↓, 1,   talin?, 1,   talin↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 21,   TGF-β↑, 2,   TGF-β↝, 1,   TGF-β1↓, 3,   THBS1↓, 1,   TIMP1↓, 2,   TIMP1↑, 14,   TIMP2↓, 1,   TIMP2↑, 11,   TIMP3↑, 1,   TRIB3↑, 1,   TSC1↑, 2,   TumCA↓, 6,   TumCA↑, 1,   TumCI↓, 258,   TumCI↑, 4,   TumCMig?, 1,   TumCMig↓, 293,   TumCMig↑, 6,   TumMeta↓, 139,   TumMeta↑, 9,   TumPF↓, 1,   Twist↓, 16,   Twist↑, 1,   TXNIP↑, 3,   uPA↓, 16,   uPAR↓, 3,   UroPA↓, 1,   Vim?, 1,   Vim↓, 52,   Vim↑, 2,   vinculin↓, 1,   Zeb1↓, 7,   ZEB2↓, 2,   ZEB2↑, 1,   α-SMA↓, 4,   α-SMA↑, 1,   α-tubulin↓, 2,   β-catenin/ZEB1↓, 77,   β-catenin/ZEB1↑, 2,   p‑β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 162,   angioG↑, 5,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 4,   EGR1↓, 1,   EGR1↑, 1,   EGR4↓, 1,   Endoglin↑, 2,   eNOS↓, 3,   HIF-1↓, 6,   Hif1a↓, 84,   Hif1a↑, 2,   Hif1a↝, 1,   Hypoxia↓, 2,   LOX1↓, 1,   NO↓, 7,   NO↑, 5,   PGI2↓, 1,   TYMP/ECGF1↓, 1,   VCAM-1↓, 4,   VEGF↓, 120,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 5,   VEGFR2/KDR/Flk1↓, 15,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1,   AQPs↓, 2,   BBB↑, 6,   BBB∅, 1,   CellMemb↑, 3,   CLDN1↓, 1,   CLDN1↑, 1,   CLDN2↓, 2,   EPR↑, 9,   GLUT1↓, 25,   GLUT1↑, 2,   GLUT1∅, 1,   GLUT2↓, 3,   GLUT3↓, 2,   GLUT3↑, 1,   GLUT3∅, 1,   GLUT4↓, 1,   IBI↑, 1,   KCNH2/hERG↓, 1,   MMP↓, 173,   MMP↑, 4,   MMP↝, 2,   MMP∅, 1,   MPT↓, 1,   MPT↑, 4,   NHE1↓, 1,   OATPs↓, 1,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2↓, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPM7↑, 1,   TRPV1↑, 3,   TRPV1↝, 1,   VGCC↑, 2,   VGSC↑, 1,   ZO-1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   B2M↓, 1,   CB2 / CNR2↓, 1,   CB2 / CNR2↑, 3,   CD155↓, 2,   CD4+↓, 1,   CD4+↑, 5,   CD44↓, 19,   CD44↝, 1,   CD47↓, 1,   CD8+↑, 11,   cDC2↓, 1,   p‑cDC2↓, 1,   COX1↓, 3,   COX1↑, 1,   COX2/PTGS2↓, 85,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCL12↓, 2,   CXCL16↓, 1,   CXCL6/GCP-2↓, 1,   CXCL9↓, 1,   CXCR2↓, 2,   CXCR4↓, 14,   DCells↑, 1,   DR4↑, 11,   DR4∅, 1,   Eos↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   Gal-3↓, 3,   Gal1↑, 1,   HMGB1↓, 5,   HMGB1↑, 1,   ICAM-1↓, 9,   IFN-γ↓, 3,   IFN-γ↑, 3,   Igs↑, 2,   IL1↓, 3,   IL1↑, 2,   IL10↓, 2,   IL10↑, 2,   IL12↑, 3,   IL17↓, 1,   IL18↓, 2,   IL1α↓, 1,   IL1β↓, 22,   IL1β↑, 2,   IL2↓, 1,   IL2↑, 2,   IL4↓, 2,   IL4↑, 2,   IL5↓, 1,   IL6↓, 49,   IL6↑, 2,   IL8↓, 12,   IL8↑, 1,   Imm↑, 25,   Imm↝, 2,   Inflam↓, 65,   IRAK1↓, 1,   IRAK4↓, 1,   LIF↑, 1,   LRIG1↑, 1,   LTA/TNF-β↓, 1,   LTA/TNF-β↑, 1,   pol-M1↑, 2,   M2 MC↓, 4,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 4,   MCT1↓, 2,   MIP2↓, 1,   mPGES-1↓, 1,   MyD88↑, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 204,   NF-kB↑, 7,   NF-kB↝, 2,   p‑NF-kB↓, 3,   p‑NF-kB↑, 2,   NFKBIZ/IκBζ↓, 1,   NK cell↑, 7,   NLRP3↓, 6,   NLRP3↑, 3,   NOD1↓, 1,   p50↓, 1,   p65↓, 9,   p65↑, 1,   p‑p65↓, 1,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 10,   PD-L1↑, 3,   PGE2↓, 13,   PSA↓, 17,   SOCS-3↑, 1,   T-Cell↑, 4,   TCF↓, 5,   Th1 response↑, 2,   TIGIT↓, 1,   TLR1↑, 1,   TLR2↑, 1,   TLR4↓, 6,   TLR4↑, 2,   TNF-α↓, 42,   TNF-α↑, 8,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 3,   TRADD↑, 1,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   pH↓, 2,   pH↑, 1,   e-pH↑, 2,   i-pH↓, 1,   TAMS↓, 2,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   CAXII/CA12↑, 1,   ChE↓, 1,   PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 2,   ADRB2↓, 1,   AhR↓, 1,   AhR↑, 2,   AR↓, 24,   AR-V7?, 1,   COMT↓, 1,   CYP19?, 1,   CYP19↓, 2,   DHT↓, 1,   ER-α36↓, 3,   ER-α36↝, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   FGF21↓, 1,   NR1H4↑, 1,   NR3C2/MR↑, 2,   PPARα↓, 1,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 9,   PRL↓, 1,   RANKL↓, 2,   SRC3↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   AKR1B10↓, 1,   BioAv↓, 49,   BioAv↑, 50,   BioAv↝, 16,   BioEnh?, 1,   BioEnh↑, 1,   chemoR↓, 2,   ChemoSen?, 1,   ChemoSen↓, 4,   ChemoSen↑, 235,   ChemoSen⇅, 1,   ChemoSen↝, 1,   ChemoSen∅, 1,   CompStab↓, 2,   CompStab↑, 4,   CYP1A1↓, 3,   CYP1A1↑, 4,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP1B1↓, 2,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   DDS↑, 4,   Dose?, 11,   Dose↓, 3,   Dose↑, 7,   Dose⇅, 3,   Dose↝, 108,   Dose∅, 9,   DrugR↓, 2,   eff?, 1,   eff↓, 104,   eff↑, 145,   eff⇅, 3,   eff↝, 14,   eff∅, 4,   GSTA1↓, 1,   GSTA1↑, 1,   GSTP1/GSTπ↑, 1,   GSTZ1↓, 1,   Half-Life↓, 12,   Half-Life↑, 4,   Half-Life↝, 11,   Half-Life∅, 1,   MDR1↓, 11,   MRP↓, 1,   MRP1/ABCC1↓, 5,   MRP2↓, 1,   MRP5↓, 1,   P-gp/ABCB1↓, 20,   P-gp/ABCB1↑, 1,   P450↓, 3,   RadioS?, 1,   RadioS↑, 63,   RadioS↝, 1,   selectivity?, 1,   selectivity↑, 150,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 98,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 2,   ALAT↓, 5,   ALAT↑, 1,   ALB↑, 1,   ALP↓, 3,   ALP↑, 1,   AR↓, 24,   AST↓, 4,   AST↑, 1,   B2M↓, 1,   BloodF↓, 1,   BMD↑, 2,   BRAF↓, 1,   BRCA1↓, 3,   BUN↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 42,   p‑EGFR↓, 4,   ERα/ESR1↓, 1,   EZH2↓, 3,   Ferritin↓, 1,   Ferritin↑, 1,   FOXM1↓, 5,   HER2/EBBR2↓, 13,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 13,   IL6↓, 49,   IL6↑, 2,   KRAS↓, 1,   LDH↓, 12,   LDH↑, 4,   LDH↝, 2,   e-LDH↑, 1,   Maspin↑, 1,   Myc↓, 5,   Myc↑, 1,   NOS2↓, 1,   PD-L1↓, 10,   PD-L1↑, 3,   Polyps↓, 2,   PSA↓, 17,   TP53↓, 1,   TP53↑, 3,   TRIB3↑, 1,   Tumccf↓, 9,   Tumccf↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 87,   AntiCan∅, 1,   antiD↑, 1,   antiNeop↑, 6,   AntiTum↓, 2,   AntiTum↑, 37,   cachexia↓, 3,   cardioP↑, 6,   CardioT↓, 1,   CardioT↑, 1,   chemoP?, 1,   chemoP↑, 48,   chemoPv↑, 32,   ChemoSideEff↓, 5,   ChemoSideEff∅, 1,   fatigue↓, 1,   FTO↓, 1,   FTO↑, 2,   hepatoP↓, 1,   hepatoP↑, 9,   kidSt↓, 1,   neuroP↓, 1,   neuroP↑, 11,   NP/CIPN↓, 3,   OS↑, 30,   OS∅, 1,   Pain↓, 3,   PFS↑, 1,   PFS∅, 1,   Pin1↓, 2,   QoL↑, 11,   QoL∅, 1,   radioP↑, 15,   Remission↑, 2,   RenoP↑, 8,   Risk↓, 39,   Risk↑, 1,   Strength↑, 1,   TGFβR1↓, 1,   toxicity?, 1,   toxicity↓, 42,   toxicity↑, 6,   toxicity⇅, 1,   toxicity↝, 14,   toxicity∅, 3,   TumNum?, 1,   TumNum↓, 2,   TumVol?, 1,   TumVol↓, 58,   TumVol↑, 1,   TumVol∅, 1,   TumW↓, 30,   TumW∅, 1,   Weight↑, 1,   Weight∅, 4,   Wound Healing↓, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiP↑, 2,   Bacteria↓, 2,   GutMicro↑, 11,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 4,   Ingr↑, 1,   Ingr↝, 18,  
Total Targets: 1504

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 8,   antiOx↑, 101,   mt-antiOx↑, 1,   ARE↑, 2,   Catalase↑, 33,   Fenton↓, 1,   GPx↑, 26,   GPx1↑, 1,   GPx4↑, 1,   GSH↓, 2,   GSH↑, 31,   GSR↑, 7,   GSTs↑, 8,   H2O2↓, 3,   HDL↓, 1,   HDL↑, 4,   HO-1?, 1,   HO-1↓, 2,   HO-1↑, 21,   hyperG↓, 1,   hyperG↝, 1,   Keap1↓, 4,   Keap1↝, 1,   lipid-P↓, 26,   MDA↓, 20,   MDA↑, 1,   MPO↓, 4,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 4,   NRF2↓, 2,   NRF2↑, 40,   RNS↓, 5,   ROS?, 3,   ROS↓, 83,   ROS↑, 7,   ROS⇅, 1,   ROS∅, 1,   mt-ROS?, 1,   selenoP↑, 1,   SOD↑, 36,   SOD1↑, 6,   SOD2↑, 3,   TAC↑, 4,   TBARS↓, 2,   VitC↑, 2,   VitE↓, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,   IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 2,   mtDam↓, 1,   OCR↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   ACSL4↓, 1,   ALAT↓, 9,   AMPK↑, 6,   ATP↓, 1,   ATP↑, 6,   CRM↑, 1,   ECAR↓, 1,   ECAR∅, 1,   glucose↓, 6,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↑, 4,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 2,   HK2↑, 1,   HMG-CoA↓, 1,   LDHA↑, 1,   LDL↓, 7,   lipidLev↓, 2,   NADPH↓, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   Apoptosis↓, 5,   ASC↓, 1,   BAX↓, 3,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-2↑, 3,   Bcl-xL↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 8,   Casp3↑, 2,   cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 1,   Fas↓, 2,   FasL↓, 1,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 11,   iNOS↑, 2,   necrosis↓, 1,   p38↓, 3,   p‑p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 6,   Akt↝, 1,   p‑Akt↑, 2,   ERK↓, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IκB?, 1,   JAK↓, 1,   JAK2↑, 1,   JNK↓, 2,   JNK↑, 2,   p‑JNK↓, 4,   MAPK↓, 7,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 3,   mTOR↑, 2,   PDGFR-BB↓, 1,   PI3K↓, 2,   PI3K↑, 5,   PKCδ↓, 1,   PKCδ↑, 1,   RIP1↓, 1,   STAT↓, 1,   STAT3↓, 2,   STAT3↑, 2,   STAT3↝, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   ATF2↑, 1,   ATF4↓, 1,   cMyc↓, 1,   FOXO3↑, 1,   HDAC↓, 1,   HOTAIR↑, 1,   other?, 1,   other↓, 4,   other↑, 3,   other↝, 8,   PhotoS↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 2,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 2,   P53↑, 1,   PARP↑, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   E2Fs↑, 1,   P21↑, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   Diff↑, 1,   Diff↝, 1,   EP2↓, 1,   FGF↑, 1,   HH↓, 1,   neuroG↑, 2,   NOTCH↓, 1,   TumCP↓, 10,   TumCP↑, 1,   Wnt↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 1,   EMT↑, 1,   FAK↑, 1,   LAMs↑, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP9↓, 2,   Smad1↑, 1,   TGF-β↓, 2,   TGF-β↑, 3,   TumCI↓, 2,   TumCMig↓, 2,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 1,   E-sel↓, 1,   Hif1a↓, 1,   NO↓, 11,   VCAM-1↓, 4,   VEGF↓, 3,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 6,   BBB↝, 1,   GastroP↑, 3,   GLUT1↓, 1,   GLUT2↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 3,   MMP↑, 4,   MMP∅, 1,   SVCT-2↑, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   COX1↓, 4,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 4,   IFN-γ↓, 6,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 2,   IL10↑, 3,   IL12↓, 2,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 22,   IL2↓, 1,   IL23↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6?, 1,   IL6↓, 22,   IL6↑, 1,   IL8↓, 4,   Imm↑, 11,   Imm⇅, 1,   Imm↝, 1,   Inflam?, 1,   Inflam↓, 106,   Inflam↑, 1,   IRF3↓, 2,   LPS↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MCP1/CCL2↑, 1,   MyD88↓, 2,   NF-kB?, 1,   NF-kB↓, 28,   NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 6,   NLRP3↑, 2,   p65↓, 1,   PGE2↓, 6,   RAGE↓, 1,   SOCS-3↓, 1,   TLR2↓, 2,   TLR4↓, 6,   TLR4↑, 1,   TLR4∅, 1,   TNF-α?, 1,   TNF-α↓, 29,   TNF-α↑, 1,   Treg lymp↝, 1,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 2,   Ach↑, 1,   AChE↓, 12,   AChE↑, 1,   BChE↓, 3,   BDNF↑, 7,   proBDNF↑, 1,   ChAT↑, 1,   GABA↑, 2,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 4,   TPH1↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 1,   Aβ↓, 10,   BACE/β-secretase↓, 3,   tau↓, 1,   p‑tau↓, 3,   XO↓, 1,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   Estro↓, 1,   PPARγ↑, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 37,   BioAv↑, 49,   BioAv↝, 21,   BioEnh↑, 2,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 15,   eff↓, 1,   eff↑, 9,   eff↝, 2,   GSTA1↑, 2,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 9,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↑, 1,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 9,   ALP↓, 2,   AST↓, 10,   BG↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 7,   creat↓, 2,   CRP↓, 3,   HOMA↓, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 22,   IL6↑, 1,   IRes↝, 1,   LDH↓, 4,   NOS2↓, 2,   RAGE↓, 1,   SpO2↑, 1,   TC↓, 2,   TG/TAG↓, 2,   Urea↓, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 7,   antiAll↑, 13,   AntiArt↑, 6,   AntiCan↓, 2,   AntiCan↑, 21,   antiCG↑, 2,   antiD↑, 1,   AntiDiabetic↓, 3,   AntiDiabetic↑, 22,   antiPs↑, 2,   AntiTum↑, 9,   ANXi↓, 1,   Bone Healing↑, 1,   cardioP?, 1,   cardioP↑, 34,   CardioT↓, 1,   chemoP↑, 8,   chemoPv↑, 5,   cognitive↓, 1,   cognitive↑, 16,   diuretic↑, 2,   hepatoP↓, 2,   hepatoP↑, 37,   Learn↑, 1,   memory↑, 14,   Mood↑, 1,   motorD↓, 1,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 59,   Obesity↓, 15,   OS↑, 1,   Pain↓, 1,   QoL↓, 1,   radioP↑, 3,   RenoP↓, 1,   RenoP↑, 14,   Risk↓, 2,   Sleep↑, 2,   Stress↓, 2,   Stroke↓, 11,   toxicity↓, 48,   toxicity↑, 3,   toxicity↝, 9,   toxicity∅, 12,   Weight↑, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 11,   AntiFungal↑, 4,   AntiP↓, 1,   AntiP↑, 3,   AntiViral↑, 13,   Bacteria↓, 21,   GutMicro↑, 16,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   CA↑, 1,   Catechins↑, 1,   FA↑, 1,   Fibre↑, 1,   GA↑, 1,   Ingr↑, 2,   Ingr↝, 7,   LT↑, 1,   Myr↑, 1,   Phen↑, 1,   Poly↑, 1,   QC↑, 2,  
Total Targets: 448

Scientific Paper Hit Count for: TumCP, Tumor Cell proliferation
44 Curcumin
25 Quercetin
24 Luteolin
24 Thymoquinone
23 Magnetic Fields
23 Shikonin
19 EGCG (Epigallocatechin Gallate)
19 Sulforaphane (mainly Broccoli)
18 Berberine
18 Resveratrol
18 Matrine
17 Phenethyl isothiocyanate
17 Kaempferol
17 Licochalcone A
16 Silver-NanoParticles
16 Radiotherapy/Radiation
16 Baicalein
14 Cisplatin
14 Apigenin (mainly Parsley)
14 Melatonin
14 Capsaicin
14 phytic acid, Inositol hexakisphosphate
13 Propolis -bee glue
13 Formononetin
13 Honokiol
13 Magnolol
12 Artemisinin
12 Fisetin
12 Garcinol
12 Lycopene
11 Ashwagandha(Withaferin A)
11 Astaxanthin
11 Boron
11 Metformin
11 Crocetin
11 Emodin
11 Isorhamnetin
11 Juglone
11 Nimbolide
10 Chrysin
10 itraconazole
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
10 Urolithin
9 Berbamine
9 Flaxseed/Linseed
9 Gallic acid
9 Hyperoside
9 Ivermectin
8 Citric Acid
8 5-fluorouracil
8 chitosan
8 Beta-Caryophyllene
8 chaetocin
8 Dandelion Root
8 HydroxyTyrosol
8 Isobavachalcone
8 Isoliquiritigenin
8 Licorice
7 Astragalus
7 Benzyl isothiocyanate
7 Anethole/trans-Anethole
7 Paclitaxel/Taxol
7 Bufalin/Huachansu
7 Centella asiatica / Gotu kola → asiaticoside
7 Eugenol
7 Evodiamine
7 Ferulic acid
7 Gambogic Acid
7 Ginkgetin
7 isoorientin
7 Linalool
7 mebendazole
7 Mangiferin
7 Piperlongumine
6 Boswellia (frankincense)
6 Chemotherapy
6 Carnosic acid
6 Rosmarinic acid
6 Celastrol
6 Carvone
6 Cucurbitacin
6 Diclofenac
6 Diindolylmethane
6 Ellagic acid
6 isoquercitrin
6 Lemongrass Extract/Citral
6 Morin
6 Mushroom Lion’s Mane, Hericium erinaceus
6 Phenylbutyrate
6 salinomycin
6 Zyflamend
5 Allyl isothiocyanate
5 DTS(dibenzyl trisulphide) from Anamu
5 Gemcitabine (Gemzar)
5 Betulinic acid
5 Carvacrol
5 Cinnamon
5 Copper and Cu NanoParticles
5 Deguelin
5 Indole-3-carbinol
5 D-limonene
5 Fucoidan
5 Galloflavin
5 Geraniol
5 Hydrogen Gas
5 Helleborus niger extracts – Christmas Rose
5 low dose naltrexone
5 Magnetic Field Rotating
5 Patchouli Oil (Pogostemon cablin)
5 Vitamin K2
4 Allicin (mainly Garlic)
4 Atorvastatin
4 brusatol
4 Celecoxib
4 Chlorogenic acid
4 Chlorophyllin
4 Photodynamic Therapy
4 Date Fruit Extract
4 Disulfiram
4 Genistein (soy isoflavone)
4 Fenbendazole
4 Ginger/6-Shogaol/Gingerol
4 iodine
4 Inositol
4 Lutein
4 Marjoram (Origanum majorana)
4 Phycocyanin
4 Piperine
4 Ursolic acid
3 1,8-Cineole
3 Alpha-Lipoic-Acid
3 Andrographis
3 Isovitexin
3 Aspirin
3 immunotherapy
3 Docetaxel
3 α-Bisabolol / Chamomile oil
3 Butyrate
3 Caffeic acid
3 Thymol-Thymus vulgaris
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Cyclopamine
3 Cynaropicrin
3 Dichloroacetate
3 diet Methionine-Restricted Diet
3 Ginkgo biloba-EGb 761
3 Ginkgo biloba
3 Ginkgolide B
3 Vitamin C (Ascorbic Acid)
3 Lactoferrin/Talactoferrin
3 Methylene blue
3 Moringa oleifera
3 Mushroom Chaga, Inonotus obliquus
3 Oleuropein
3 Propyl gallate
3 Plumbagin
3 Pterostilbene
3 Selenium
3 Sesamin
3 Terpinen-4-ol / Tea Tree Oil
3 Aflavin-3,3′-digallate
3 VitK3,menadione
3 Walnut
3 Zerumbone
2 Sorafenib (brand name Nexavar)
2 3-bromopyruvate
2 Auranofin
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Ascorbyl Palmitate
2 Arctigenin
2 Baicalin
2 Biochanin A
2 Isothiocyanates
2 Brucea javanica
2 Bacopa monnieri
2 Beetroot
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Hydroxycinnamic-acid
2 Coenzyme Q10
2 Carica papaya leaf extract
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Dichloroacetophenone(2,2-)
2 diet FMD Fasting Mimicking Diet
2 diet Short Term Fasting
2 Echinacea
2 Eurycomanone
2 Flaxseed Oil
2 Arsenic trioxide
2 Ginkgolic acids
2 γ-linolenic acid (Borage Oil)
2 Graviola
2 Grapeseed extract
2 hydrogen sulfide
2 doxorubicin
2 Laetrile B17 Amygdalin
2 lambertianic acid
2 Lapachol
2 SDG/lignans
2 Mung Bean Sprouts
2 Modified Citrus Pectin
2 Lemon Balm/Melissa officinalis
2 Methylsulfonylmethane
2 Mistletoe/Viscum album Extracts
2 Naringin
2 Niclosamide (Niclocide)
2 Psoralidin
2 EMF
2 Rutin
2 α-Santalol/Sandalwood oil
2 Sulfasalazine
2 Salvia miltiorrhiza
2 Vitamin D3
1 2-DeoxyGlucose
1 Açaí, Euterpe oleracea
1 Glucose
1 SonoDynamic Therapy UltraSound
1 Zinc
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Fennel Oil/Foeniculum vulgare
1 Aloe anthraquinones
1 beta-glucans
1 almonertinib
1 bempedoic acid
1 Bevacizumab (brand Avastin)
1 temozolomide
1 Bromelain
1 borneol
1 Bortezomib
1 Bruteridin(bergamot juice)
1 Black turtle bean
1 Bullatacin
1 hydroxychloroquine
1 Cat’s Claw
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Cannabidiol
1 Camu camu
1 Camptothecin
1 irinotecan
1 Cranberry
1 CUSP9
1 Dasatinib/Phyrago
1 Dihydrocaffeic Acid
1 Electrical Pulses
1 Exercise
1 Vitamin E
1 ferumoxytol
1 Trastuzumab
1 tamoxifen
1 Vitamin A, Retinoic Acid
1 Shilajit/Fulvic Acid
1 Ginseng
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 HydroxyCitric Acid
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 Hibiscus sabdariffa
1 Hops (Humulus lupulus)
1 Hyperthermia
1 Inoscavin A
1 Recombinant Methioninase
1 L-Theanine
1 Lactobacillus
1 MCT, metronomic chemo
1 Methyl Jasmonate
1 methylseleninic acid
1 Caffeine
1 Magnesium
1 Methylglyoxal
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 magnetic nanoparticles
1 Mucuna pruriens/Velvet Bean
1 Mushroom Maitake
1 nicotinamide adenine dinucleotide
1 Bicarbonate(Sodium)
1 Oroxylin-A
1 Oleocanthal
1 Proanthocyanidins
1 sericin
1 Purple Corn / Purple Maize
1 xanthohumol
1 Pomi-T
1 Propranolol
1 Gold NanoParticles
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Oxaliplatin
1 Selenium NanoParticles
1 Lignans
1 diet Plant based
1 Spirulina(Arthrospira/Limnospira)
1 Spermidine
1 tetrathiomolybdate
1 Tumor Treating Fields
1 Turmerones
1 Usnic acid
1 Vitexin
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:327  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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