VEGF Cancer Research Results

VEGF, Vascular endothelial growth factor: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
A signal protein produced by many cells that stimulates the formation of blood vessels. Vascular endothelial growth factor (VEGF) is a signal protein that plays a crucial role in angiogenesis, the process by which new blood vessels form from existing ones. This process is vital for normal physiological functions, such as wound healing and the menstrual cycle, but it is also a key factor in the growth and spread of tumors in cancer.
Because of its significant role in tumor growth and progression, VEGF has become a target for cancer therapies. Anti-VEGF therapies, such as monoclonal antibodies (e.g., bevacizumab) and small molecule inhibitors, aim to inhibit the action of VEGF, thereby reducing blood supply to tumors and limiting their growth. These therapies have been used in various types of cancer, including colorectal, lung, and breast cancer.
Scientific Papers found: Click to Expand⟱
8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, *AntiCan↑, *AMPK↑, *β-HEX↓, NA↑, TumCCA↑, AMPK↑, ACC↑, p‑Akt↓, FOXM1↓, CycB/CCNB1↓, XIAP↓, Bcl-2↓, p‑STAT3↓, p‑NF-kB↓, Bcl-xL↓, survivin↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ROS↑, STK11/LKB1↑, cl‑Casp3↑, cl‑PARP↑, Synergy↑, AR↓, TumCP↓, p‑P53↓, P21↓, p27/CDKN1B↓, cycD1/CCND1↓, CDK4↓, PSA↓, STAT3↓, ac‑p65↓, *antiAll↑,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8222- LCA,    Licochalcone A Induces Cholangiocarcinoma Cell Death Via Suppression of Nrf2 and NF-κB Signaling Pathways
- in-vitro, CCA, KKU-100 - in-vitro, CCA, KKU-213 - in-vitro, CCA, KKU-214 - in-vitro, CCA, KKU-156 - in-vitro, 0-Reserved, KKU-452
TumCP?, TumCD?, ROS↑, NRF2↓, BAX↑, Cyt‑c↑, TumCMig↓, TumCCA↑, NF-kB↓, STAT3↓, cycD1/CCND1↓, VEGF↓, ICAM-1↓,
8224- LCA,    3,3',4,4'-Tetrahydroxy-2-methoxychalcone from Glycyrrhiza uralensis roots inhibits HIF-1α and Nrf2, suppressing hypoxia-induced angiogenesis
- in-vitro, CRC, HCT116
Hif1a↓, NRF2↓, VEGF↓, HO-1↓, ROS↓,
8290- LE,    Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells
- vitro+vivo, Pca, DU145
*toxicity↝, Apoptosis↑, TumCCA↑, TumCMig↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, COX2/PTGS2↓, VEGF↓, MMP9↓, ICAM-1↓, VCAM-1↓,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8140- LF,    Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
P53↑, AChE↑, Ach↓, VEGF↓, Akt↓,
8293- lign,  FS,    Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivo
- in-vivo, BC, MCF7
TumCG↓, angioG↓, VEGF↓, Dose↝,
8311- lign,    The Power of Lignans: Plant Compounds with Multifaceted Health-Promoting Effects
- Review, Nor, NA
*cardioP↑, *AntiDiabetic↑, *Obesity↓, *Bacteria↓, *AntiFungal↑, *AntiViral↑, *neuroP↑, *antiOx↑, *lipid-P↓, *memory↑, *CREB↑, *BDNF↑, *PSD95↑, *β-Amyloid↓, *TNF-α↓, *IL6↓, *IL10↓, *GutMicro↑, *Endoglin↑, *END↑, *cognitive↑, *Akt↓, *IκB↓, *NF-kB↓, *HO-1↑, *VEGF↑, *p‑eNOS↑, *GRP78/BiP↓, *PERK↓, *ATF4↓, *CHOP/DDIT3↓, *SREBP1/SREBF1↓, *ROS↓, TumVol↓,
8393- LT,    Progress, pharmacokinetics and future perspectives of luteolin modulating signaling pathways to exert anticancer effects: A review
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, EMT↓, Imm↝, ChemoSen↑, *Inflam↓, *COX2/PTGS2↓, *NF-kB↓, MMP2↓, MMP9↓, p‑Akt↓, p‑PI3K↓, IGF-2↓, IGF-1R↓, CXCL16↓, NOTCH1↓, HES1↓, VEGF↓, ROS↑,
8401- LT,    Multi-Faceted Role of Luteolin in Cancer Metastasis: EMT, Angiogenesis, ECM Degradation and Apoptosis
- Review, Var, NA
EMT↓, N-cadherin↓, Vim↓, VEGF↓, VEGFR1↓, MMPs↓, Telomerase↓, NF-kB↓, cMyc↓, Bax:Bcl2↑, Casp3↑, PI3K↓, Akt↓, FOXO3↑, P21↑, p27/CDKN1B↑, cl‑PARP↑, Cyt‑c↑, NOTCH↓, HES1↓, ROS↑, SOD↓, miR-34b-5p↑, Hif1a↓, P21↓, survivin↓, Mcl-1?, Bcl-xL↓, MDM2↓, MMP2↓, MMP9↓, MMP3↓, MMP16↓, miR-384↑, NRF2↓, HO-1↓, angioG↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
3267- Lyco,    Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways
- in-vitro, Nor, HUVECs
*VEGF↓, *MMP2↓, *uPA↓, *Rac1↑, *TIMP2↑, *p38↓, *Akt↓, *angioG↓,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, Synergy↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
8421- Lyco,    Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *AntiMyl↑, *ROS↓, *MMP↑, *NGF↑, *BDNF↑, *VEGF↑, *Aβ42↓, *PI3K↑, *Akt↑, *NRF2↑, *lipid-P↓, *GSH↑, *Catalase↑, *SOD↑, *cognitive↑, *Learn↑, *memory↑, *APP↓, *BACE/β-secretase↓, *ADAM10↑, *NF-kB↓, *AChE↓, *MAOA↓, *BioAv↝,
4782- Lyco,    New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, TumCI↓, TumCA↓, ROS↓, MMP2↓, MMP7↓, MMP9↓, VEGF↓, E-cadherin↑, TIMP1↑, TIMP2↑, BioAv↝, *IL12↓, *TNF-α↓, *IL1↓, *IL1β↓, *IL6↓, COX2/PTGS2↓, iNOS↓, *radioP↑, NF-kB↓, survivin↓, Casp3↑, Bax:Bcl2↑,
4516- MAG,    Magnolol Induces Apoptosis and Suppresses Immune Evasion in Non-small Cell Lung Cancer Xenograft Models
- in-vivo, NSCLC, NA
selectivity↑, Apoptosis↑, TumCCA↑, Casp3↑, cycD1/CCND1↓, CDK4↓, VEGF↓, FOXP3↓, IDO1↓,
4519- MAG,    Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiAg↑, *BBB↑, *BioAv↓, BAD↑, Casp3↑, Casp6↑, Casp9↑, JNK↑, Bcl-xL↓, PTEN↑, Akt↓, NF-kB↓, MMP7↓, MMP9↓, uPA↓, Hif1a↓, VEGF↓, FOXO3↓, Ca+2↑, TumCCA↑, ROS↑, Cyt‑c↑,
972- MAG,    Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1α/VEGF signaling pathway in human bladder cancer cells
- vitro+vivo, Bladder, T24/HTB-9
angioG↓, VEGF↓, H2O2↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Akt↓, mTOR↓, P70S6K↓, 4E-BP1↓, TumCG↓, CD31/PECAM-1↓, CA↓,
8574- Matr,    Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration
- in-vitro, Lung, A549 - ex-vivo, HCC, SMMC-7721 cell
TumCG↓, Bcl-2↓, BAX↑, TumCMig↓, tumCV∅, VEGF↓, Synergy↑,
8536- Matr,    Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway
- vitro+vivo, BC, 4T1 - in-vitro, BC, MCF7
tumCV↓, Apoptosis↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, angioG↓,
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8631- MBZ,  BEV,    Mebendazole; from an anti-parasitic drug to a promising candidate for drug repurposing in colorectal cancer
- Trial, CRC, NA
Dose?, Synergy↑, PFS↑, VEGF↓, ChemoSen↑,
8648- MBZ,    Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature
- Review, Var, NA
angioG↓, MMPs↓, MDR1↓, TubPol↓, RadioS?, ChemoSen?, TumCG↓, TumMeta?, OS↑, BioAv↓, BioAv↑, BBB↑, mitA↑, HH↓, Shh↓, Synergy↑, Gli1↓, PTCH2↓, XIAP↓, cl‑PARP↑, Casp3↑, BRAF↓, MEK↓, SYN1↑, Cyt‑c↑, TumVol↓, VEGFR2/KDR/Flk1↓, VEGF↓, VCAM-1↓, DYRK1B↓, QoL↑, Dose↝,
2500- MBZ,    Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme
- in-vitro, GBM, U87MG - in-vivo, GBM, NA
α-tubulin↓, AntiCan↑, TumCG↓, OS↑, VEGF↓, Hif1a↓,
2487- mCHEMO,    Metronomic Chemotherapy: Possible Clinical Application in Advanced Hepatocellular Carcinoma
- Review, HCC, NA
toxicity↓, toxicity↓, eff↝, angioG↓, CSCs↓, TSP-1↑, Hif1a↓, VEGF↓, eff↑,
8716- MeJa,    Methyl jasmonate abolishes the migration, invasion and angiogenesis of gastric cancer cells through down-regulation of matrix metalloproteinase 14
- in-vitro, GC, SGC-7901 - in-vitro, GC, MKN-28
TumCMig↓, TumCI↓, angioG↓, MMP14↓, VEGF↓, Sp1/3/4↓,
8750- MeSA,    Methylseleninic acid restricts tumor growth in nude mice model of metastatic breast cancer probably via inhibiting angiopoietin-2
- vitro+vivo, BC, MDA-MB-231
ANGPT2↓, VEGF↓, TumVol↓, TumW↓,
8749- MeSA,  etoposide,    Methylseleninic acid enhances the effect of etoposide to inhibit prostate cancer growth in vivo
- in-vivo, Pca, NA
TumCG↓, Apoptosis↑, p‑ERK↓, p‑Akt↓, FABP5/E-FABP↓, angioG↓, VEGF↓, ChemoSen↑,
8758- MeSA,    Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential
- vitro+vivo, RCC, 786-O - in-vitro, Kidney, Caki-1
TGF-β1↓, PD-L1↓, VEGF↓, TumCG↓,
8762- MeSA,    Methylseleninic Acid Sensitizes Ovarian Cancer Cells to T-Cell Mediated Killing by Decreasing PDL1 and VEGF Levels
- in-vitro, Ovarian, A2780S
selectivity↑, NK cell↑, T-Cell↑, PD-L1↓, Hif1a↓, VEGF↓, ROS↑, *NRF2↑,
5241- MF,    A review on the use of magnetic fields and ultrasound for non-invasive cancer treatment
- Review, Var, NA
other↑, BloodF↑, Glycolysis↓, ATP↓, VEGF↓, ROS↑, P-gp/ABCB1↓, Apoptosis↑, selectivity↑, Ca+2↑, Catalase↑,
2243- MF,    Pulsed electromagnetic fields increase osteogenetic commitment of MSCs via the mTOR pathway in TNF-α mediated inflammatory conditions: an in-vitro study
- in-vitro, Nor, NA
*eff↑, *mTOR↑, *Akt↑, *PKA↑, *MAPK↑, *ERK↑, *BMP2↑, *Diff↑, *PKCδ↓, *VEGF↑, *IL10↑,
4150- MF,    Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice
- in-vitro, Nor, NA
*BDNF↑, *VEGF↑,
4111- MF,    Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell
- Review, Arthritis, NA
*Inflam↓, *Cartilage↑, *Pain↓, *QoL↑, *Dose↝, *VEGF↑, *NO↑, *TGF-β↑, *MMP9↓, *PGE2↑, *GPx3↑, *SOD2↑, *Catalase↑, *GSR↑, *Ca+2↑,
3477- MF,    Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosis
- Review, Var, NA
*Ca+2↑, *VEGF↑, *angioG↑, Ca+2↑, ROS↑, Necroptosis↑, TumCCA↑, Apoptosis↑, *ATP↑, *FAK↑, *Wnt↑, *β-catenin/ZEB1↑, *ROS↑, p38↑, MAPK↑, β-catenin/ZEB1↓, CSCs↓, TumCP↓, ROS↑, RadioS↑, Ca+2↑, eff↓, NO↑,
3476- MF,    Pulsed Electromagnetic Fields Stimulate HIF-1α-Independent VEGF Release in 1321N1 Human Astrocytes Protecting Neuron-like SH-SY5Y Cells from Oxygen-Glucose Deprivation
- in-vitro, Stroke, 1321N1 - in-vitro, Park, NA
*VEGF↑, *eff↑, *neuroP↑, *other↑, *eff↑, *Inflam↓, *Hif1a∅,
3479- MF,    Evaluation of Pulsed Electromagnetic Field Effects: A Systematic Review and Meta-Analysis on Highlights of Two Decades of Research In Vitro Studies
- Review, Var, NA
*eff↓, eff↝, *Hif1a↑, *VEGF↑, *TIMP1↑, *E2Fs↑, *MMP2↑, *MMP9↑, Apoptosis↑,
3501- MF,    Unveiling the Power of Magnetic-Driven Regenerative Medicine: Bone Regeneration and Functional Reconstruction
- Review, Nor, NA
*VEGF↑, *BMPs↓, *SMAD4↑, *SMAD5↑, *Ca+2↑,
3536- MF,    Targeting Mesenchymal Stromal Cells/Pericytes (MSCs) With Pulsed Electromagnetic Field (PEMF) Has the Potential to Treat Rheumatoid Arthritis
- Review, Arthritis, NA - Review, Stroke, NA
*Inflam↓, *Diff↑, *toxicity∅, *other↑, *SOX9↑, *COL2A1↑, *NO↓, *PGE2↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *angioG↑, *MSCs↑, *VEGF↑, *TGF-β↑, *angioG↝, *VEGF↓, Ca+2↝,
3478- MF,    One Month of Brief Weekly Magnetic Field Therapy Enhances the Anticancer Potential of Female Human Sera: Randomized Double-Blind Pilot Study
- Trial, BC, NA - in-vitro, BC, MCF7 - in-vitro, Nor, C2C12
TumCP↓, TumCMig↓, TumCI↓, *toxicity∅, TGF-β↓, Twist↓, Slug↓, β-catenin/ZEB1↓, Vim↓, p‑SMAD2↓, p‑SMAD3↓, angioG↓, VEGF↓, selectivity↑, LIF↑,
3480- MF,    Cellular and Molecular Effects of Magnetic Fields
- Review, Nor, NA
ROS↑, *Ca+2↑, *Inflam↓, *Akt↓, *mTOR↓, selectivity↑, *memory↑, *MMPs↑, *VEGF↑, *FGF↑, *PDGF↑, *TNF-α↑, *HGF/c-Met↑, *IL1↑,
3482- MF,    Pulsed Electromagnetic Fields Increase Angiogenesis and Improve Cardiac Function After Myocardial Ischemia in Mice
- in-vitro, Nor, NA
*cardioP↑, *VEGF↑, *VEGFR2/KDR/Flk1↑, *Hif1a↑, *FGF↑, *ITGB1↑, *angioG↑,
499- MF,    The Effect of Pulsed Electromagnetic Fields on Angiogenesis
- Review, Var, NA
*angioG↑, *VEGF↑, *VGCC↑,
194- MF,    Electromagnetic Field as a Treatment for Cerebral Ischemic Stroke
- Review, Stroke, NA
*BAD↓, *BAX↓, *Casp3↓, *Bcl-xL↑, *p‑Akt↑, *MMP9↓, *p‑ERK↑, *HIF-1↓, *ROS↓, *VEGF↑, *Ca+2↓, *SOD↑, *IL2↑, *p38↑, *HSP70/HSPA5↑, *Apoptosis↓, *ROS↓, *NO↓,
8671- MLT,    Targeting mitochondrial metabolism in renal cell carcinoma with melatonin: Preclinical evidence and clinical perspectives
- Review, RCC, NA
OXPHOS↑, Warburg↓, ROS↑, Akt↓, mTOR↓, NF-kB↓, HIF-1↓, VEGF↓, MAPK↓, TumCG↓, angioG↓, TumCI↓, Apoptosis↑, TumAuto↑, Synergy↑, *toxicity↓,

Showing Research Papers: 301 to 350 of 466
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 466

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 8,   antiOx⇅, 1,   ARE↓, 1,   Catalase↓, 8,   Catalase↑, 4,   Copper↑, 1,   Fenton↑, 1,   GPx↓, 3,   GPx↑, 4,   GPx4↓, 4,   GSH↓, 26,   GSH↑, 5,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 2,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 9,   HO-1↑, 15,   HO-2↓, 1,   Iron↑, 1,   Iron∅, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 9,   MDA↓, 5,   MDA↑, 4,   MPO↓, 2,   NADH↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 2,   NQO1↑, 3,   NRF2↓, 24,   NRF2↑, 24,   NRF2↝, 1,   p‑NRF2↓, 1,   OSI↑, 1,   Prx4↑, 1,   PrxI↓, 1,   PYCR1↓, 1,   ROMO1↑, 1,   ROS?, 1,   ROS↓, 16,   ROS↑, 175,   ROS⇅, 12,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 11,   SOD↑, 6,   SOD2↓, 4,   TAC↓, 3,   Thiols↓, 1,   TOS↑, 1,   Trx1↑, 1,   ox-Trx1↑, 1,   TrxR↓, 5,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR-ABL↓, 1,   CDC2↓, 8,   CDC25↓, 8,   EGF↓, 6,   ETC↓, 2,   HSP60/HSPD1↓, 2,   mitResp↓, 4,   MKK7↓, 2,   Mortalin↓, 1,   mtDam↑, 10,   OCR↓, 3,   OCR↑, 2,   OXPHOS↓, 2,   OXPHOS↑, 3,   PINK1↑, 1,   SIRT3↓, 2,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 6,   AApath↓, 1,   ACC↑, 2,   ALAT↓, 5,   ALAT↑, 1,   ALAT↝, 1,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 20,   p‑AMPK↑, 1,   p‑AMT/GCST/T-protein↑, 1,   ARG↓, 1,   ATP↓, 14,   ATP↑, 1,   ATP↝, 1,   i-ATP↓, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 2,   CAIX/CA9↑, 1,   CYP4A/CYP4A11/CYP4A22↓, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 1,   FABP5/E-FABP↓, 1,   FASN↓, 7,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↓, 1,   GlucoseCon↓, 10,   GlutMet↓, 1,   Glycolysis↓, 31,   GSK‐3β↓, 11,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 7,   HK2↓, 12,   IDO1↓, 1,   lactateProd↓, 11,   lactateProd↑, 1,   e-lactateProd↓, 1,   LDHA↓, 9,   LDL↓, 1,   MCT4↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 11,   PDK3↑, 1,   PFK↓, 1,   PKM2↓, 11,   PKM2↑, 1,   p‑S6↓, 2,   SCD1↓, 1,   SIRT1↓, 6,   SIRT1↑, 8,   SIRT2↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 2,   TCA↑, 1,   TS↓, 1,   Warburg↓, 7,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 152,   Apoptosis↝, 1,   mt-Apoptosis↑, 2,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 2,   BAD↓, 3,   BAD↑, 9,   Bak↑, 11,   BAX↓, 2,   BAX↑, 86,   BAX⇅, 1,   BAX↝, 1,   BAX∅, 1,   Bax:Bcl2↑, 26,   Bcl-2↓, 116,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-2∅, 1,   Bcl-xL↓, 41,   Bcl-xL↝, 1,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 4,   BIM↓, 1,   BIM↑, 4,   BNIP3↑, 3,   BNIP3↝, 1,   Casp↓, 1,   Casp↑, 33,   Casp↝, 1,   cl‑Casp↑, 1,   Casp1↓, 2,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 2,   Casp3?, 1,   Casp3↓, 3,   Casp3↑, 118,   Casp3↝, 1,   cl‑Casp3↑, 17,   proCasp3↑, 1,   Casp6↑, 1,   Casp7?, 1,   Casp7↑, 16,   cl‑Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 29,   cl‑Casp8↑, 6,   proCasp8↑, 1,   Casp9?, 1,   Casp9↑, 69,   cl‑Casp9↑, 9,   proCasp9↓, 1,   cFLIP↓, 5,   Cyt‑c↑, 67,   Cyt‑c↝, 3,   mt-Cyt‑c↓, 1,   Diablo↑, 10,   DIDO1/DIO-1↑, 1,   DR5↑, 21,   Endon↑, 1,   FADD↑, 3,   Fas↑, 22,   FasL↑, 6,   Ferroptosis↑, 7,   GSDME↑, 1,   HEY1↓, 2,   IAP1↓, 14,   IAP1↑, 1,   IAP2/BIRC3↓, 7,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICAD↑, 1,   iNOS↓, 21,   JWA↑, 1,   Mcl-1?, 1,   Mcl-1↓, 29,   MDM2↓, 9,   MDM2↑, 1,   p‑MDM2↓, 2,   MOMP↑, 2,   Necroptosis↑, 4,   necrosis↑, 3,   NOXA↑, 4,   oncosis↑, 1,   p38↓, 10,   p38↑, 16,   p‑p38↓, 3,   p‑p38↑, 3,   PUMA↑, 5,   Pyro↑, 3,   RIP1↑, 2,   RIP3↑, 2,   survivin↓, 68,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAIL⇅, 1,   TRAILR↑, 4,   TumCD?, 1,   TumCD↑, 6,   TUNEL↑, 1,   XIAP?, 1,   XIAP↓, 35,   XIAP↑, 1,   YAP/TEAD↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 135,   Akt↑, 4,   Akt↝, 1,   Akt∅, 1,   p‑Akt↓, 36,   BRAF↓, 1,   Brk/PTK6↓, 1,   CK2↓, 5,   cMET↓, 3,   p‑cMET↑, 2,   cSrc↓, 3,   DYRK1B↓, 1,   EGFR↓, 45,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 2,   ERK↓, 52,   ERK↑, 7,   ERK↝, 1,   ERK∅, 1,   p‑ERK↓, 16,   p‑ERK↑, 2,   ERK5↓, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 9,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 6,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 14,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 2,   p‑IκB↓, 1,   JAK↓, 3,   JAK1↓, 4,   p‑JAK1↓, 1,   JAK2↓, 17,   p‑JAK2↓, 3,   JNK↓, 6,   JNK↑, 20,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 29,   MAPK↑, 12,   MAPK↝, 1,   MARK4↓, 1,   MEK↓, 10,   MKK4↓, 2,   mTOR↓, 81,   mTOR↝, 1,   p‑mTOR↓, 9,   mTORC2↓, 1,   p‑p70S6↓, 2,   P70S6K↓, 5,   p‑P70S6K↓, 2,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 106,   PI3K↝, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 1,   p‑PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 11,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 30,   PTEN↝, 1,   p‑PTEN↓, 1,   PTPN6↑, 1,   Raf↓, 7,   e-Raf↓, 1,   RAS↓, 10,   RAS↑, 1,   p‑S6K↓, 2,   SHP1↑, 4,   Sp1/3/4↓, 17,   Src↓, 4,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 3,   STAT3↓, 86,   p‑STAT3↓, 20,   p‑STAT3↑, 3,   STAT5↓, 4,   STAT6↓, 3,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 5,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 5,   cJun↑, 1,   cMyc↓, 46,   p‑cMyc↑, 1,   DNMT1↓, 7,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 8,   EZH2↓, 2,   FOXM1↓, 6,   FOXO↑, 2,   FOXO1↓, 2,   FOXO3↓, 5,   FOXO3↑, 5,   FOXO3↝, 1,   FOXO4↓, 2,   H3↓, 1,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 3,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 2,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 27,   HDAC1↓, 5,   HDAC2↓, 2,   HDAC3↓, 2,   HDAC4↓, 1,   HDAC8↓, 2,   HES1↓, 2,   HOTAIR↓, 1,   KISS1↑, 1,   miR-10a-5p↝, 1,   miR-133a-3p↑, 1,   miR-134↑, 1,   miR-155↝, 1,   miR-194↑, 1,   miR-200b↑, 2,   miR-200c↑, 1,   miR-203↓, 1,   miR-203↑, 1,   miR-21↓, 5,   miR-21↑, 1,   miR-21↝, 1,   miR-210↓, 1,   miR-210↑, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-30a-5p↑, 1,   miR-34a↑, 3,   miR-34a↝, 1,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-548ah-5p↑, 1,   Myc↓, 9,   MYCN↓, 1,   n-MYC↓, 1,   NDRG1↑, 1,   NEAT1↓, 1,   OCT4↓, 7,   other?, 1,   other↓, 1,   other↑, 3,   other↝, 6,   other∅, 1,   PAX2↓, 1,   PCAF↓, 1,   PhotoS↑, 1,   Prot↓, 1,   SOX2↓, 7,   SOX4↓, 1,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   SUV39H↓, 2,   TFAP2A↓, 1,   tumCV↓, 29,   tumCV∅, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 24,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 2,   eIF2α↑, 2,   p‑eIF2α↑, 2,   ER Stress↓, 2,   ER Stress↑, 29,   GRP78/BiP↓, 3,   GRP78/BiP↑, 9,   HSP27↓, 3,   HSP27↑, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP90↓, 11,   HSPs↓, 2,   HTRA↓, 2,   IRE1↑, 2,   PERK↑, 3,   p‑PERK↑, 1,   UPR↑, 7,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 5,   ATG5↝, 1,   ATG7↑, 2,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 14,   Beclin-1/ATG6↝, 1,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 1,   LC3B-II↑, 3,   LC3II↓, 2,   LC3II↑, 12,   LC3s↑, 1,   p62↓, 9,   p62↑, 3,   PARK2↑, 1,   RUBCN↓, 1,   TumAuto↓, 1,   TumAuto↑, 28,   TumAuto⇅, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATM?, 1,   ATM↑, 1,   p‑ATM↑, 2,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA1↝, 1,   BRCA2↓, 1,   BRCA2↑, 1,   DFF45↓, 2,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 45,   DNArepair↓, 3,   DNArepair↑, 2,   m-FAM72A↓, 1,   HR↓, 1,   hTERT/TERT↓, 14,   p16↑, 5,   P53?, 1,   P53↓, 4,   P53↑, 74,   P53↝, 1,   p‑P53↓, 1,   p‑P53↑, 4,   PARP↓, 3,   PARP↑, 18,   PARP↝, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 57,   PARP1↑, 3,   cl‑PARP1↑, 1,   PCNA↓, 28,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 15,   TOP1↓, 9,   TOP2↓, 6,   TOP2↑, 2,   TP53↓, 1,   TP53↑, 3,   UHRF1↓, 1,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 7,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 37,   CDK2↑, 1,   CDK4↓, 46,   CDK4↑, 1,   CDK4/6↓, 2,   CDK6↓, 21,   CDK6↑, 1,   CDK8↓, 2,   CDKN1C/p57↑, 1,   CHK1↓, 3,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 1,   p‑Chk2↑, 2,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 8,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 20,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 82,   cycD1/CCND1↑, 1,   cycD1/CCND1↝, 1,   CycD3↓, 2,   cycE/CCNE↓, 15,   cycE/CCNE↑, 2,   cycE1↓, 2,   cycF↓, 1,   E2Fs↓, 5,   E2Fs↑, 1,   GADD45A↓, 1,   GADD45A↑, 1,   Ki-67↓, 24,   mitA↑, 2,   P21↓, 4,   P21↑, 55,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 27,   pRB↑, 1,   p‑pRB↓, 2,   RB1↑, 1,   p‑RB1↓, 6,   TubPol↓, 1,   TumCCA↓, 6,   TumCCA↑, 151,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 1,   ALDH↓, 4,   BMP2↓, 1,   BMP7/OP1↓, 1,   BMPs↑, 3,   CD133↓, 5,   CD133↑, 1,   CD24↓, 1,   CD34↓, 2,   cFos↓, 3,   cFos↑, 1,   cMYB↓, 2,   CSCs↓, 39,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 4,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 10,   HH↓, 7,   IGF-1?, 1,   IGF-1↓, 11,   IGF-2↓, 1,   IGFBP3↑, 5,   Jun↓, 1,   Ki-67↓, 24,   Let-7↑, 5,   MCM2↓, 1,   mTORC1↓, 2,   p‑mTORC1↓, 1,   Nanog↓, 6,   Nestin↓, 3,   NICD↓, 1,   NOTCH↓, 17,   NOTCH1↓, 12,   NOTCH1↑, 3,   NOTCH3↓, 3,   p300↓, 2,   PTCH1↓, 3,   PTCH2↓, 1,   SCF↓, 2,   Shh↓, 11,   Smo↓, 6,   STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TumCG↓, 79,   TumCG↑, 2,   TumCP?, 1,   TumCP↓, 115,   TumCP↑, 1,   tyrosinase↓, 2,   Wnt↓, 38,   Wnt↑, 2,   Wnt/(β-catenin)↓, 9,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   ANGPT2↓, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 14,   AP-1↝, 1,   ARG1/2↑, 1,   ATPase↓, 1,   AXL↓, 3,   BACH1↓, 1,   CA↓, 3,   Ca+2↓, 1,   Ca+2↑, 28,   Ca+2↝, 3,   CAFs/TAFs↓, 2,   cal2↓, 1,   cal2↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 2,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 10,   E-cadherin↑, 45,   EM↑, 1,   EMT?, 1,   EMT↓, 72,   EMT↑, 1,   EMT↝, 1,   EpCAM↓, 3,   F-actin↓, 3,   FAK↓, 22,   p‑FAK↓, 4,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 3,   GIT1↓, 1,   GLI2↓, 4,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 1,   LAMs↓, 3,   LEF1↓, 1,   LRP1↓, 1,   MALAT1↓, 2,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 3,   MMP1↓, 8,   MMP13↓, 4,   MMP14↓, 1,   MMP16↓, 1,   MMP2↓, 115,   MMP2↝, 1,   MMP3↓, 11,   MMP7↓, 13,   MMP9↓, 146,   MMP9↑, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 42,   MMPs↝, 1,   MRGPRF↓, 1,   MTA1↓, 1,   MUC4↓, 2,   N-cadherin↓, 28,   NCAM↑, 1,   PAK1↓, 1,   pax↓, 1,   PDGF↓, 11,   Rac1↓, 3,   RECK↑, 2,   Rho↓, 5,   Rho↑, 1,   ROCK1↓, 5,   ROCK1↑, 2,   Slug↓, 10,   Smad1↓, 1,   Smad1↑, 1,   SMAD2↓, 2,   p‑SMAD2↓, 1,   SMAD3↓, 3,   p‑SMAD3↓, 1,   Snail?, 1,   Snail↓, 24,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 24,   TGF-β↑, 2,   TGF-β1↓, 3,   TIMP1↓, 2,   TIMP1↑, 12,   TIMP2↓, 3,   TIMP2↑, 14,   TIMP3↑, 1,   TSC1↑, 1,   TSP-1↑, 5,   TumCA↓, 2,   TumCI↓, 68,   TumCMig↓, 73,   TumCMig↑, 1,   TumMeta?, 1,   TumMeta↓, 72,   TumMeta↑, 5,   Twist↓, 26,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 29,   uPAR↓, 4,   UroPA↓, 1,   Vim?, 1,   Vim↓, 34,   Vim↑, 1,   Zeb1↓, 12,   Zeb1↑, 1,   ZEB2↓, 3,   α-SMA↓, 4,   α-tubulin↓, 2,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 47,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 169,   angioG↑, 5,   angioS↑, 1,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 14,   EGR1↑, 1,   Endoglin↓, 1,   Endoglin↑, 1,   eNOS↓, 4,   HIF-1↓, 11,   Hif1a↓, 141,   LOX1↓, 3,   NO↓, 8,   NO↑, 2,   NO↝, 1,   VCAM-1↓, 4,   VEGF↓, 412,   VEGF↑, 5,   VEGF↝, 2,   VEGFR1↓, 7,   VEGFR2/KDR/Flk1↓, 29,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 4,   CLDN1↓, 3,   CLDN1↑, 1,   CLDN2↓, 1,   CLDN2↑, 1,   CTR1↑, 2,   CX43/GJA1↓, 1,   EPR↑, 4,   EPR↝, 1,   GLUT1↓, 20,   GLUT1↑, 1,   GLUT3↑, 1,   IBI↑, 1,   KCNH2/hERG↓, 1,   MMP↓, 67,   MMP↑, 5,   MMP∅, 1,   MPT↑, 4,   NHE1↓, 2,   OCLN↑, 1,   TJ↑, 1,   TRPM7↓, 2,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↑, 2,   CD44↓, 14,   CD8+↑, 2,   COX1↓, 3,   COX2/PTGS2↓, 96,   COX2/PTGS2↑, 3,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 4,   CXCL16↓, 1,   CXCR2↓, 1,   CXCR4↓, 20,   CXCR4↑, 1,   DR4↑, 6,   FOXP3↓, 2,   GM-CSF↓, 2,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 12,   IFN-γ↓, 3,   IFN-γ↑, 3,   Igs↑, 1,   IL1↓, 10,   IL10↓, 8,   IL10↑, 3,   IL12↓, 4,   IL12↑, 1,   IL1α↓, 2,   IL1β↓, 13,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 7,   IL4↓, 2,   IL4↑, 1,   IL6↓, 52,   IL6↑, 1,   IL6↝, 1,   IL8↓, 16,   Imm↑, 10,   Imm↝, 3,   INF-γ↑, 1,   Inflam↓, 26,   LIF↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 6,   MCT1↓, 1,   MDSCs↓, 2,   MIP2↓, 2,   mPGES-1↓, 3,   MyD88↓, 1,   MyD88↑, 1,   NF-kB↓, 157,   NF-kB↑, 1,   NF-kB↝, 2,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 9,   NLRP3↓, 4,   NLRP3↑, 2,   p50↓, 1,   p65↓, 10,   p65↑, 1,   p‑p65↓, 4,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 11,   PGE2↓, 16,   PSA↓, 9,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 3,   Th2↑, 1,   TLR4↓, 8,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 39,   TNF-α↑, 4,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRAF1↓, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   Ach↓, 1,   AChE↑, 1,   SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AhR↑, 1,   AhR↓, 1,   AR↓, 18,   AR↝, 1,   CYP19↓, 2,   ER-α36↓, 2,   ER-α36↝, 1,   ER(estro)↓, 2,   Estro↝, 1,   FGF21↓, 2,   GR↑, 1,   PPARα↓, 3,   cl‑PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 9,   RANKL↓, 1,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   BioAv↓, 42,   BioAv↑, 48,   BioAv↝, 6,   BioEnh↑, 5,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 128,   ChemoSen⇅, 1,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1A2↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 4,   Dose↓, 1,   Dose↑, 9,   Dose↝, 33,   Dose∅, 7,   eff↓, 16,   eff↑, 54,   eff↝, 15,   eff∅, 1,   Half-Life↓, 13,   Half-Life↑, 3,   Half-Life↝, 8,   Half-Life∅, 2,   MDR1↓, 10,   MRP1/ABCC1↓, 6,   P-gp/ABCB1↓, 15,   P450↓, 4,   RadioS?, 1,   RadioS↑, 46,   selectivity↑, 50,   Synergy↑, 90,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 3,   ALAT↓, 5,   ALAT↑, 1,   ALAT↝, 1,   ALP↓, 4,   ALP↝, 1,   AR↓, 18,   AR↝, 1,   ascitic↓, 3,   AST↓, 4,   AST↑, 1,   AST↝, 1,   BloodF↓, 1,   BloodF↑, 1,   BRAF↓, 1,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA1↝, 1,   CEA↓, 1,   CRP↓, 3,   E6↓, 3,   E7↓, 3,   EGFR↓, 45,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 2,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 6,   HER2/EBBR2↓, 9,   hTERT/TERT↓, 14,   IL6↓, 52,   IL6↑, 1,   IL6↝, 1,   IRes↓, 1,   LDH↓, 2,   LDH↑, 2,   Maspin↑, 1,   Myc↓, 9,   NSE↓, 1,   PD-L1↓, 11,   PSA↓, 9,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   TP53↓, 1,   TP53↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 40,   AntiCan∅, 1,   antiNeop↑, 7,   AntiTum↑, 14,   cachexia↓, 2,   cardioP↑, 6,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 23,   chemoPv↑, 19,   ChemoSideEff↓, 7,   fatigue↓, 2,   hepatoP↑, 5,   Mucositis↓, 1,   neuroP↑, 7,   NP/CIPN↓, 1,   Obesity↓, 1,   ORR↑, 1,   OS↑, 19,   Pain↓, 1,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 4,   radioP↑, 9,   Remission↑, 1,   RenoP↑, 6,   Risk↓, 12,   Risk↑, 1,   Sleep↑, 1,   toxicity↓, 15,   toxicity↑, 3,   toxicity↝, 4,   toxicity∅, 1,   TumVol↓, 24,   TumW↓, 11,   Weight↓, 1,   Weight↑, 2,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 1080

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 2,   antiOx↓, 1,   antiOx↑, 64,   Catalase↓, 1,   Catalase↑, 36,   Fenton↓, 1,   GPx↓, 1,   GPx↑, 20,   GPx3↑, 1,   GPx4↑, 1,   GSH↑, 24,   GSR↑, 6,   GSTs↑, 9,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 18,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 24,   MDA↓, 22,   MPO↓, 4,   MPO↑, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 40,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 93,   ROS↑, 1,   mt-ROS?, 1,   SOD↑, 37,   SOD1↑, 2,   SOD2↑, 3,   TBARS↓, 2,   TOS↓, 1,   uricA↓, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   PDH↑, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 4,   5LO↝, 1,   ALAT↓, 15,   AMPK↓, 1,   AMPK↑, 6,   p‑AMPK↑, 1,   ATP↑, 2,   cytoP450↓, 1,   glucose↓, 5,   GlucoseCon↑, 3,   Glycolysis↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   H2S↑, 1,   HK1↑, 1,   LDL↓, 4,   lipidLev↓, 1,   NADPH↓, 2,   NADPH↑, 1,   PDKs↓, 1,   SIRT1↑, 8,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 9,   ASC?, 1,   ASC↓, 1,   BAD↓, 1,   BAX↓, 6,   Bax:Bcl2↓, 2,   Bcl-2↓, 1,   Bcl-2↑, 3,   Bcl-xL↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp3?, 1,   Casp3↓, 14,   cl‑Casp8↑, 1,   Casp9↓, 4,   Cyt‑c↓, 4,   Fas↓, 1,   Ferroptosis↓, 2,   IAP1↓, 1,   iNOS↓, 10,   iNOS↑, 2,   p38↓, 3,   p38↑, 1,   Pyro?, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 9,   Akt↑, 6,   p‑Akt↑, 2,   AKT1↑, 1,   CREB↑, 1,   EGFR↓, 1,   ERK↓, 2,   ERK↑, 1,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IKKα↑, 1,   IκB?, 1,   IκB↓, 1,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 2,   p‑LIMK1↑, 1,   MAPK↓, 8,   MAPK↑, 3,   mTOR↓, 4,   mTOR↑, 2,   P70S6K↓, 1,   PI3K↓, 8,   PI3K↑, 5,   PKA↑, 1,   PKCδ↓, 2,   PKCδ↑, 1,   PTEN↑, 1,   Sp1/3/4↓, 1,   Sp1/3/4↑, 1,   STAT↓, 1,   STAT3↓, 4,   STAT3↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   cMyc↓, 2,   HDAC↓, 1,   OCT4↓, 1,   other↓, 2,   other↑, 6,   other↝, 4,   SOX18↑, 1,   SOX9↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   ER Stress↓, 2,   GRP78/BiP↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,   HSP90↑, 1,   HSPs↑, 1,   PERK↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,   DNAdam↓, 3,   P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD45A↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↓, 1,   CD133↑, 1,   Diff↑, 2,   FGF↑, 2,   IGF-1↓, 1,   IGFBP3↑, 1,   MSCs↑, 1,   neuroG↑, 1,   TumCP↓, 3,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 5,   Ca+2↑, 4,   Ca+2↝, 1,   Cartilage↑, 2,   p‑Cofilin↑, 1,   COL1↑, 1,   COL2A1↑, 1,   COL3A1↓, 1,   FAK↑, 1,   ITGB1↑, 1,   p‑MLC2/MYL9↑, 1,   MMP13↓, 1,   MMP2↓, 3,   MMP2↑, 2,   MMP3↓, 1,   MMP9↓, 6,   MMP9↑, 3,   MMPs↑, 1,   MYPT1 / PPP1R12A↑, 1,   p‑MYPT1 / PPP1R12A↑, 1,   N-cadherin↑, 2,   PAI-1/SERPINE1↓, 1,   PDGF↑, 1,   Rac1↑, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↑, 1,   SLIT2↑, 1,   SMAD4↑, 1,   SMAD5↑, 1,   TGF-β↓, 3,   TGF-β↑, 3,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   uPA↓, 1,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   angioG↑, 15,   angioG↝, 1,   CD31/PECAM-1↓, 2,   CD31/PECAM-1↑, 2,   E-sel↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   eNOS↑, 1,   p‑eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 5,   Hif1a↑, 6,   Hif1a∅, 1,   NO↓, 14,   NO↑, 3,   VCAM-1↓, 6,   VEGF↓, 22,   VEGF↑, 32,   VEGFR2/KDR/Flk1↓, 1,   VEGFR2/KDR/Flk1↑, 1,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 9,   BBB↝, 1,   GLUT2↑, 1,   GLUT3↑, 3,   GLUT4↑, 3,   MMP↑, 6,   MUC19↓, 1,   MUC2↓, 1,   MUC5AC↓, 1,   OATPs↓, 1,   OCLN↓, 1,   TRPC1↓, 1,   VGCC↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 29,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 3,   ICAM-1↓, 5,   IFN-γ↓, 3,   IL1↓, 4,   IL1↑, 1,   IL10↓, 3,   IL10↑, 9,   IL12↓, 2,   IL13↓, 1,   IL17↓, 3,   IL18↓, 3,   IL1β↓, 20,   IL2↓, 3,   IL2↑, 1,   IL23↓, 1,   IL4↓, 6,   IL4↑, 1,   IL5↓, 3,   IL6↓, 31,   IL6↑, 1,   IL8↓, 4,   Imm↑, 5,   Imm⇅, 1,   Inflam?, 1,   Inflam↓, 89,   Inflam↑, 1,   IRF3↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 3,   MyD88↓, 2,   NF-kB↓, 43,   NF-kB↑, 1,   NLRP3↓, 9,   p65↓, 1,   PGE2↓, 13,   PGE2↑, 2,   RAGE↓, 1,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 5,   TLR4∅, 1,   TNF-α↓, 34,   TNF-α↑, 2,   Treg lymp↝, 1,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 1,   AChE↓, 12,   ADAM10↑, 1,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 8,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 4,   PSD95↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 2,   Aβ↓, 13,   Aβ42↓, 1,   BACE/β-secretase↓, 4,   tau↓, 3,   p‑tau↓, 8,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   CYP19↓, 1,   END↑, 1,   Estro↓, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 3,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 32,   BioAv↑, 24,   BioAv↝, 9,   BioEnh↑, 2,   CompStab↑, 2,   Dose↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 9,   eff↓, 1,   eff↑, 11,   eff↝, 1,   GSTA1↑, 2,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 9,   Half-Life∅, 3,   P-gp/ABCB1↓, 1,   P450↓, 2,   selectivity↑, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 15,   ALP↓, 5,   ascitic↓, 1,   AST↓, 18,   BMD↑, 2,   BP↓, 2,   p‑BRCA1↑, 1,   BUN↓, 1,   creat↓, 1,   CRP↓, 4,   EGFR↓, 1,   IL6↓, 31,   IL6↑, 1,   LDH↓, 7,   LDH↑, 1,   NOS2↓, 1,   RAGE↓, 1,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AirwayM↓, 1,   Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 16,   AntiArt↑, 7,   AntiCan↓, 1,   AntiCan↑, 8,   antiD↓, 1,   AntiDiabetic↑, 14,   AntiMyl↑, 1,   antiPs↑, 2,   AntiTum↑, 1,   cardioP↑, 32,   chemoP↑, 8,   chemoPv↑, 1,   cognitive↓, 1,   cognitive↑, 18,   diuretic↑, 1,   hepatoP↑, 31,   Learn↑, 2,   memory↑, 21,   motorD↑, 4,   Mucositis↓, 1,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 58,   Obesity↓, 9,   OS↑, 2,   Pain↓, 5,   QoL↑, 1,   radioP↑, 5,   RenoP↓, 1,   RenoP↑, 8,   Stroke↓, 6,   toxicity↓, 22,   toxicity↑, 2,   toxicity↝, 6,   toxicity∅, 9,   Weight↑, 1,   Wound Healing↓, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 3,   AntiViral↑, 10,   Bacteria↓, 16,   Bacteria↑, 1,   GutMicro↑, 13,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,  
Total Targets: 437

Scientific Paper Hit Count for: VEGF, Vascular endothelial growth factor
17 Thymoquinone
16 Apigenin (mainly Parsley)
15 Curcumin
14 Magnetic Fields
13 EGCG (Epigallocatechin Gallate)
12 Resveratrol
11 Betulinic acid
11 Sulforaphane (mainly Broccoli)
10 Quercetin
10 Garcinol
9 Baicalein
9 Berberine
9 Chrysin
8 Silver-NanoParticles
8 Propolis -bee glue
8 Fisetin
8 Kaempferol
7 Artemisinin
7 Boswellia (frankincense)
7 Silymarin (Milk Thistle) silibinin
6 Radiotherapy/Radiation
6 Fucoidan
6 Luteolin
6 Melatonin
5 Beta-Caryophyllene
5 Chlorogenic acid
5 Ellagic acid
5 Emodin
5 Formononetin
5 Gambogic Acid
5 Hydrogen Gas
5 Honokiol
4 Cisplatin
4 Ashwagandha(Withaferin A)
4 Bevacizumab (brand Avastin)
4 Caffeic acid
4 Cinnamon
4 Deguelin
4 D-limonene
4 Ferulic acid
4 Isoliquiritigenin
4 Juglone
4 Lycopene
4 Matrine
4 methylseleninic acid
4 Methylsulfonylmethane
4 Nimbolide
4 Phenethyl isothiocyanate
3 Alpha-Lipoic-Acid
3 Chemotherapy
3 Boron
3 Capsaicin
3 Carvacrol
3 Crocetin
3 Diindolylmethane
3 Eugenol
3 Flaxseed/Linseed
3 Ginkgolide B
3 iodine
3 phytic acid, Inositol hexakisphosphate
3 Licochalcone A
3 Magnolol
3 mebendazole
3 Naringin
3 Piperine
3 Selenite (Sodium)
2 Biochanin A
2 Thymol-Thymus vulgaris
2 Celecoxib
2 Celastrol
2 chaetocin
2 Cucurbitacin
2 Ursolic acid
2 Diclofenac
2 Gallic acid
2 Gemcitabine (Gemzar)
2 Genistein (soy isoflavone)
2 Ginger/6-Shogaol/Gingerol
2 Gossypol/AT-101
2 Proanthocyanidins
2 Hydroxycinnamic-acid
2 HydroxyTyrosol
2 Hyperoside
2 MCT, metronomic chemo
2 lambertianic acid
2 Licorice
2 SDG/lignans
2 Phenylbutyrate
2 Piperlongumine
2 Rosmarinic acid
2 Shikonin
2 Vitamin C (Ascorbic Acid)
1 1,8-Cineole
1 Annona atemoya Seed Extract
1 Auranofin
1 Astragalus
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 Andrographis
1 Isovitexin
1 Ascorbyl Palmitate
1 Astaxanthin
1 Aloe anthraquinones
1 beta-glucans
1 immunotherapy
1 Baicalin
1 Berbamine
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Centella asiatica / Gotu kola → asiaticoside
1 chitosan
1 Coenzyme Q10
1 Vitamin E
1 Carvone
1 Dandelion Root
1 Ginkgo biloba-EGb 761
1 Docetaxel
1 Bortezomib
1 olaparib/LYNPARZA
1 Paclitaxel/Taxol
1 Ginkgetin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Grapeseed extract
1 Hibiscus sabdariffa
1 Hops (Humulus lupulus)
1 Indole-3-carbinol
1 Inositol
1 Extracorporeal Shock Wave Therapy
1 isoflavones
1 isoorientin
1 itraconazole
1 Lactoferrin/Talactoferrin
1 Methyl Jasmonate
1 vp16, etoposide
1 Moringa oleifera
1 tamoxifen
1 Mistletoe/Viscum album Extracts
1 Mushroom Shiitake, AHCC
1 Myricetin
1 Niclosamide (Niclocide)
1 Neem
1 Oleuropein
1 Marjoram (Origanum majorana)
1 Plumbagin
1 VitK3,menadione
1 Psoralidin
1 Pterostilbene
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Sanguinarine
1 Salvia miltiorrhiza
1 Theobromine
1 Aflavin-3,3′-digallate
1 Urolithin
1 Vitamin D3
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:334  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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