STAT3 Cancer Research Results

STAT3, Signal transducer and activator of transcription 3: Click to Expand ⟱
Source:
Type: Oncogene
Stat3 (Signal Transducer and Activator of Transcription 3) is a transcription factor that plays a crucial role in various cellular processes, including cell growth, survival, differentiation, and immune response.
Stat3 is frequently found to be constitutively activated in many types of cancers, including breast, prostate, lung, and head and neck cancers. (associated with poor prognosis and reduced survival.)

-STAT3 is typically activated by cytokines (such as IL-6) and growth factors binding to their respective receptors.
-Activated STAT3 upregulates the expression of genes that promote cell cycle progression (e.g., cyclin D1) and anti-apoptotic proteins (e.g., Bcl-2, Bcl-xL).
Scientific Papers found: Click to Expand⟱
4793- Lyco,    Lycopene treatment inhibits activation of Jak1/Stat3 and Wnt/β-catenin signaling and attenuates hyperproliferation in gastric epithelial cells
- in-vitro, GC, AGS
antiOx↑, AntiCan↑, ROS↓, JAK1↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, cycE/CCNE↓, TumCP↓, Risk↓,
1197- MAG,    Magnolol as STAT3 inhibitor for treating multiple sclerosis by restricting Th17 cells
- in-vivo, MS, NA
Weight↑, Th17↓, STAT3↓,
8500- MAG,    Magnolol Induces Apoptosis Through Extrinsic/intrinsic Pathways and Attenuates NF-κB/STAT3 Signaling in Non-small-cell Lung Cancer Cells
- in-vitro, NSCLC, A549
NF-kB↓, STAT3↓, EMT↓,
8513- MAG,    Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I
- vitro+vivo, Oral, SCC4 - in-vitro, Tong, SCC9 - in-vitro, SCC, CAL27
TumCG↓, TumMeta↓, *toxicity↓, Ingr?, chemoPv↑, compI↓, mitResp↓, ETC↓, AMPK↑, STAT3↓, ox-PrxI↑, Dose↝, Ki-67↓, STAT3↓, P70S6K↓, HK2↓, survivin↓, BioAv↝, Half-Life↝, ROS↑,
8506- MAG,    Magnolia officinalis Lignans induce apoptosis and epigenetic reprogramming via the miR-148a-3p/DNMT-1/UTF-1 axis in pancreatic cancer cells
- in-vitro, PC, Panc02 - in-vitro, PC, MIA PaCa-2
*Inflam↓, *antiOx↑, Ingr↝, tumCV↓, Apoptosis↑, ROS↑, MMP↓, Casp↑, selectivity↑, DNMT1↓, JAK2↓, STAT3↓, miR-148a↑, UTF1↑, IL6↓, survivin↓,
8541- Matr,    Matrine induces ferroptosis and suppresses colorectal cancer through targeting the STAT3/SLC7A11 pathway
- in-vivo, CRC, NA
TumCP↓, necrosis↑, Ferroptosis↑, TumCD↑, lipid-P↑, MDA↑, GSH↓, xCT/SLC7A11↓, P53↑, p‑STAT3↓,
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8555- Matr,    Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
- Review, Var, NA
*AntiTum↑, *Inflam↓, *Analgesic↑, *AntiViral↑, *Imm↑, *PI3K↑, *Akt↑, *mTOR↑, TumAuto↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, E-cadherin↑, Vim↓, MMP2↓, MMP9↓, Snail↓, Slug↓, PTEN↑, TumCP↓, TumCMig↓, TumCI↓, ChemoSen↑, ROS↑, uPA↓, p‑ERK↓, cachexia↓, antiD↑, GSK‐3β↓, LC3B-II↑, p62↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, FOXO1↑, FOXO3↑, FOXO4↑, PARP↑, BIM↑, Bcl-2↓, survivin↓, miR-21↓, *HOTAIR↑, *p‑Akt↑, *p‑STAT3↑, *STAT3↑, *ROS↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, JAG1↓, HES1↓, BioAv↝, toxicity↝,
8547- Matr,    Matrine in cancer therapy: antitumor mechanisms and nano-delivery strategies
- Review, Var, NA
*Ingr↝, *AntiTum↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, TumCMig↓, TumCI↓, JPT1/HN1↓, Erlin1↑, LINC01116↓, miR-592↑, ERK↓, JAK↓, STAT3↓, miR-182-5p↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, Sharpin↓, ROS↓, AMPK↑, mTOR↓, Snail↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, E-cadherin↑, PTEN↑, miR-10b-5p↓, GPx4↓, lipid-P↑, Iron↑, Piezo1↑,
8628- MBZ,    Mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated STAT3 signaling downregulation in non-small cell lung cancer
- vitro+vivo, Lung, A549 - in-vitro, Lung, H460
TumCP↓, TumCMig↓, Apoptosis↑, ROS↑, p‑JAK2↓, p‑STAT3↓, eff↓, TumCG?, Bcl-xL↓, EMT↓, Snail↓, Twist↓,
8819- MCP,  PacT,    Pectasol‐C Modified Citrus Pectin targets Galectin‐3‐induced STAT3 activation and synergize paclitaxel cytotoxic effect on ovarian cancer spheroids
- in-vitro, Ovarian, SKOV3
Gal-3↓, ChemoSen↑, STAT3↓, Hif1a↓, Akt↓, TumCMig↓, TumCI↓, ITGA2↓, ITGA5↓, ITGA6↓, ITGB1↓, ITGB3↓, ITGB4↓,
8816- MCP,    Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, 4T1
GlucoseCon↓, GLUT1↓, Gal-3↓, ROS↓, NRF2↓, Hif1a↓, angioG↓, pol-M2 MC↓, p‑STAT3↓, TumCG↓, TumW↓,
8761- MeSA,    Methylseleninic Acid Suppresses Breast Cancer Growth via the JAK2/STAT3 Pathway
- in-vitro, BC, 4T1
TumCI↓, Apoptosis↑, Casp3↑, PARP1↑, BAX↑, JAK2↓, STAT3↓,
2379- MET,    Down‐regulation of PKM2 enhances anticancer efficiency of THP on bladder cancer
- in-vitro, Bladder, T24/HTB-9 - in-vitro, BC, UMUC3
PKM2↓, p‑STAT3↓, TumCG↓, Synergy↑, chemoP↑, AMPK↑,
2378- MET,    Metformin inhibits epithelial-mesenchymal transition of oral squamous cell carcinoma via the mTOR/HIF-1α/PKM2/STAT3 pathway
- in-vitro, SCC, CAL27 - in-vivo, NA, NA
TumCP↓, TumCMig↓, TumCI↓, EMT↓, mTOR↓, Hif1a↓, PKM2↓, STAT3↓, E-cadherin↑, Vim↓, Snail↓, STAT3↓,
533- MF,    Effects of extremely low-frequency magnetic fields on human MDA-MB-231 breast cancer cells: proteomic characterization
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCD↑, necrosis↑, mt-ROS↑, other↑, *STAT3↓, STAT3↑,
3483- MF,    Pulsed Electromagnetic Fields Protect Against Brain Ischemia by Modulating the Astrocytic Cholinergic Anti-inflammatory Pathway
- in-vivo, Stroke, NA
*Inflam↓, *STAT3↓, *p‑STAT3↓,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
8683- MLT,    Intra-tumor ROS amplification by melatonin interferes in the apoptosis-autophagy-inflammation-EMT collusion in the breast tumor microenvironment
- in-vivo, BC, NA
ROS↑, SIRT1↑, IL6↓, STAT3↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, TumCP↓, tumCV↓, JNK↑, P53↑, Bax:Bcl2↑, cl‑Casp3↑, Apoptosis↑, eff∅, TumAuto↑, EMT↓, Half-Life↓, CompStab↓, BioAv↓, Dose↝, TumW↓, TumVol↓, Ki-67↓, PTEN↑,
8911- MO,    Anticancer Potential of Moringa Oleifera in Lung Cancer: A Mini Review of In vitro and In vivo Evidence
- Review, Lung, NA
tumCV↓, Apoptosis↑, BAX↑, Bcl-2↓, Cyt‑c↑, Casp↑, NF-kB↓, EGFR↓, STAT3↓, VEGF↓, eff↑, CD4+↑, CD8+↑,
8897- MOR,    Morin promotes prostate cancer cells chemosensitivity to paclitaxel through miR-155/GATA3 axis
- vitro+vivo, Pca, DU145 - in-vitro, Pca, PC3
tumCV↓, GATA3↑, ChemoSen↑, Dose↝, miR-155↓, MMP?, Casp3↑, Casp9↑, P21↑, BAD↑, Bcl-xL↓, STAT3↓,
8868- MOR,  PacT,    Synergistic effect of morin and paclitaxel impedes cell proliferation through PI3K/AKT/STAT3 signaling axis inhibition in gastric cancer
- in-vitro, GC, HGC27
ChemoSen↑, ROS↑, MMP↓, Apoptosis↑, cFos↓, KRAS↓, p‑ERK↓, PI3K↓, Akt↓, STAT3↓, TumCP↓,
8867- MOR,  doxoR,    Morin Sensitizes MDA-MB-231 Triple-Negative Breast Cancer Cells to Doxorubicin Cytotoxicity by Suppressing FOXM1 and Attenuating EGFR/STAT3 Signaling Pathways
- in-vitro, BC, MDA-MB-231
ChemoSen↑, EPR↑, DNAdam↑, γH2AX↑, p‑EGFR↓, p‑STAT3↓, TumCCA↑, P21↑, cycD1/CCND1↓, FOXM1↓, tumCV↓, *p38↑,
8859- MOR,    Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1
- in-vitro, Melanoma, U266 - in-vitro, BC, MCF7 - in-vitro, SCC, SCC4 - in-vitro, BC, MCF-10AT
STAT3↓, Src↓, JAK1↓, JAK2↓, PIAS-3↑, ChemoSen↑, SHP1↑, XIAP↓, cFLIP↓, Mcl-1↓, survivin↓, Bcl-2↓, Bcl-xL↓, IAP2/BIRC3↓, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, selectivity↑,
8777- MSM,  Tam,    The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts
- in-vitro, BC, MCF7 - in-vitro, BC, T47D
tumCV↓, TumCMig↓, JAK2↓, STAT5↓, ChemoSen↑, cycD1/CCND1↓, VEGF↓, IGF-1↓, IGF-1R↓, MMP2↓, MMP3↓, MMP9↓, TumVol↓, STAT3↓,
8765- MSM,    Combination of AG490, a Jak2 inhibitor, and methylsulfonylmethane synergistically suppresses bladder tumor growth via the Jak2/STAT3 pathway
- vitro+vivo, Bladder, NA
*toxicity↓, tumCV↓, TumCMig↓, TumCG↓, STAT3↓, STAT5↓, IGF-1R↓, VEGF↓, VEGFR2/KDR/Flk1↓, TumMeta↓, Synergy↑,
1203- MSM,    Methylsulfonylmethane Suppresses Breast Cancer Growth by Down-Regulating STAT3 and STAT5b Pathways
- vitro+vivo, BC, MDA-MB-231
tumCV↓, STAT3↓, STAT5↓, IGF-1↓, Hif1a↓, VEGF↓, Brk/PTK6↓, IGF-1R↓,
1170- MushCha,    Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism
- in-vitro, Oral, HSC4
tumCV↓, TumCP↓, TumCCA↑, STAT3↓, Glycolysis↓, MMP↓, TumAuto↑, p38↑, NF-kB↑,
930- MushShi,    Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation
- in-vitro, Ovarian, NA
p‑STAT3↓, PTPN6↑, cycD1/CCND1↓, Bcl-2↓, Mcl-1↓, survivin↓, VEGF↓,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, Var, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2/PTGS2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp/ABCB1↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
1269- NCL,    Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway
- in-vitro, Pca, DU145
STAT3↓, TumCG↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cMyc↓, Bcl-xL↓,
1271- NCL,    Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics
- vitro+vivo, Ovarian, SKOV3
Wnt/(β-catenin)↓, mTOR↓, STAT3↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, MEK↓, ERK↓, mitResp↓, Glycolysis↓, ROS↑, JNK↑,
5253- NCL,    Niclosamide: Beyond an antihelminthic drug
- Review, Var, NA
TumCP↓, Apoptosis↑, EMT↓, β-catenin/ZEB1↓, TumCG↓, toxicity↓, Wnt↓, LRP6↓, Synergy↑, DR5↑, mTORC1↓, pH↓, CSCs↓, IL6↓, JAK1↓, STAT3↓, ChemoSen↑, TumCG↓, tumCV↓, NOTCH↓, NF-kB↓, EGFR↓, ROS↑, RadioS↑, cFos↓, cJun↓, E2Fs↓, cMyc↓, Half-Life↓, BioAv↝,
5254- NCL,    The magic bullet: Niclosamide
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, RAS↓, STAT3↓, NOTCH↓, E2Fs↓, mTOR↓, Synergy↑, PD-1↓, PD-L1↓, BioAv↝, toxicity↓, BioAv↑, ETC↑, NADH:NAD↓, TCA↑, Warburg↓, Diff↑, AMPK↑, P53↑, PP2A↑, HIF-1↓, KRAS↓, Myc↓, RadioS↑, ChemoSen↑, Dose↝, Dose↑,
6489- Nimb,    Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model
- in-vivo, Pca, DU145 - in-vivo, Pca, LNCaP
tumCV↓, Apoptosis↑, TumCI↓, TumCMig↓, STAT3↓, ROS↑, TumCG↓, TumMeta↓, TumCCA↑, DNAdam↑, Casp3↑, Casp7↑, cl‑PARP↑, p‑STAT3↓, IL6↓, GSR↓,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP/DDIT3↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27/CDKN1B↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
4649- OLEC,    Anticancer molecular mechanisms of oleocanthal
- Review, Var, NA
Apoptosis↑, HGF/c-Met↝, STAT3↝,
4646- OLEC,    Oleocanthal as a Multifunctional Anti-Cancer Agent: Mechanistic Insights, Advanced Delivery Strategies, and Synergies for Precision Oncology
- Review, Var, NA
BioAv↓, *Inflam↓, *antiOx↓, cMET↓, STAT3↓, TNF-α↓, COX2/PTGS2↓, EMT↓, angioG↓, *GutMicro↝, eff↑,
4647- OLEC,    Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer
- Review, Var, NA
*Inflam↓, AntiCan↑, *COX2/PTGS2↓, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓, TumCP↓, *AntiAg↑, mTOR↓, STAT3↓, ERK↓, p‑Akt↓, Bcl-2↓, ROS↑, PSA↓,
1227- OLST,    Anti-Obesity Drug Orlistat Alleviates Western-Diet-Driven Colitis-Associated Colon Cancer via Inhibition of STAT3 and NF-κB-Mediated Signaling
- in-vivo, CRC, NA
OS↑, Inflam↓, TumCG↓, STAT3↓, NF-kB↓, β-catenin/ZEB1↓, Slug↓, XIAP↓, CDK4↓, cycD1/CCND1↓, Bcl-2↓,
8449- OM,    Ethanolic extract of Origanum syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties
- in-vitro, BC, MDA-MB-231
antiOx↑, ROS↑, TumCP↓, TumCCA↑, p‑p38↑, P21↑, Ki-67↓, eff↓, Apoptosis↑, Casp3↑, STAT3↑, P53↑, TumCMig↓, TumCI↓, FAK↓, iNOS↓, angioG↓,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, Synergy↑, Synergy↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
4918- PEITC,    Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
- Review, Var, NA
Apoptosis↑, TumCP↓, angioG↓, TumMeta↓, NF-kB↓, Akt↓, MAPK↓, *BioAv↓, ROS↑, lipid-P↑, AIF↑, Cyt‑c↑, DR4↑, DR5↑, TumCCA↑, JAK↓, STAT3↓, MMP2↓, MMP9↓, PKCδ↓, Hif1a↓, JNK↓, Mcl-1↓, COX2/PTGS2↓, MMP↓, Casp3↑, ChemoSen↑, *BioAv↓, Half-Life↓,
4936- PEITC,    PEITC treatment suppresses myeloid derived tumor suppressor cells to inhibit breast tumor growth
- in-vivo, BC, MDA-MB-231
TumCG↓, CD34↓, CD11b↓, CSCs↓, ALC∅, CD4+↓, NF-kB↓, STAT3↓, Hif1a↓,
5186- PEITC,    Phenethyl Isothiocyanate inhibits STAT3 activation in prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
TumCP↓, TumCCA↑, STAT3↓, p‑JAK2↓, eff↓, TumCCA↑, AR↓, ROS↑,
5211- PI,    Piperine inhibits colorectal cancer migration and invasion by regulating STAT3/Snail-mediated epithelial-mesenchymal transition
- in-vitro, CRC, NA
TumCMig↓, TumCI↓, EMT↓, Snail↓, STAT3↓,
3597- PI,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, AD, NA - Review, Park, NA - Review, Var, NA
*NF-kB↓, *MAPK↓, *AP-1↓, *COX2/PTGS2↓, *NOS2↓, *IL1β↓, *TNF-α↓, *PGE2↓, *STAT3↓, *IL10↑, *IL4↓, *IL5↓, P53↑, MMP9↓, MMP2↓, cMyc↓, VEGF↓, STAT3↓, survivin↓, p65↓, *antiAll↑,

Showing Research Papers: 301 to 350 of 428
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 428

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 9,   Catalase↓, 7,   Catalase↑, 4,   Copper↓, 1,   Fenton↑, 2,   GPx↓, 2,   GPx↑, 4,   GPx1↓, 1,   GPx4↓, 7,   GSH↓, 22,   GSH↑, 2,   GSR↓, 2,   GSR↑, 2,   GSTs↓, 1,   H2O2↑, 3,   HO-1↓, 4,   HO-1↑, 12,   HO-2↓, 1,   Iron↓, 1,   Iron↑, 4,   Iron↝, 1,   i-Iron↑, 1,   Keap1↑, 2,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 11,   MDA↓, 2,   MDA↑, 6,   MPO↓, 1,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 1,   NQO1↓, 1,   NQO1↑, 4,   NRF2↓, 22,   NRF2↑, 14,   NRF2↝, 1,   p‑NRF2↓, 1,   Prx↓, 1,   Prx3↑, 1,   Prx4↑, 1,   ox-PrxI↑, 1,   PrxII↓, 2,   ROS↓, 19,   ROS↑, 185,   ROS⇅, 7,   ROS∅, 2,   i-ROS↑, 1,   mt-ROS↑, 5,   SOD↓, 6,   SOD↑, 4,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 1,   TAC?, 1,   TBARS↑, 1,   Trx↓, 2,   Trx1↑, 1,   TrxR↓, 7,   TrxR1↓, 2,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 6,   CDC25↓, 5,   compI↓, 2,   compII↓, 1,   compIV↓, 1,   compV↓, 1,   ETC↓, 2,   ETC↑, 1,   HSP60/HSPD1↓, 1,   mitResp↓, 7,   MKK7↓, 1,   mtDam↑, 17,   OCR↓, 8,   OXPHOS↓, 6,   SIRT3↓, 2,   SIRT3↑, 2,   SSBP1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 4,   ACC↑, 1,   ACLY↓, 1,   ALAT↓, 4,   ALAT↝, 1,   ALDOA↓, 1,   AMPK↓, 2,   AMPK↑, 25,   AMPK↝, 1,   ATP↓, 14,   mt-ATP↓, 1,   BMAL1↝, 1,   CAIX/CA9↑, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 1,   FABP4↓, 1,   FAO↓, 1,   FAO↑, 1,   FASN↓, 4,   G6PD↓, 1,   GLO-I↓, 2,   GLS↓, 1,   glucose↓, 4,   GlucoseCon↓, 13,   GlucoseCon↑, 1,   glut↓, 1,   GlutMet↑, 1,   Glycolysis↓, 29,   GSK‐3β↓, 9,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 5,   HK2↓, 16,   HMG-CoA↓, 1,   HSD17B4↓, 1,   lactateProd↓, 16,   lactateProd↑, 1,   LAR↓, 1,   LDHA↓, 8,   LDL↓, 1,   MCT4↓, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PFK↓, 1,   PFK1↓, 1,   PKM2↓, 14,   PKM2↑, 1,   p‑PKM2↓, 1,   PLA2↓, 1,   PPP↓, 1,   Pyruv↓, 1,   p‑S6↓, 1,   SCD1↓, 2,   SIRT1↓, 7,   SIRT1↑, 7,   SIRT2↓, 2,   SREBF2↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   TCA↑, 2,   TS↓, 1,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 8,   APAF1↑, 4,   Apoptosis?, 2,   Apoptosis↓, 4,   Apoptosis↑, 157,   mt-Apoptosis↑, 3,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 2,   BAD↑, 4,   Bak↑, 4,   BAX↓, 4,   BAX↑, 82,   BAX↝, 1,   BAX∅, 1,   Bax:Bcl2↑, 19,   Bcl-2↓, 105,   Bcl-2↑, 6,   Bcl-2∅, 1,   Bcl-xL↓, 41,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 3,   BIM↑, 5,   BNIP3↑, 3,   Casp↑, 26,   Casp↝, 1,   cl‑Casp↑, 2,   Casp1↓, 2,   Casp10↑, 1,   Casp12↑, 2,   Casp3?, 1,   Casp3↓, 2,   Casp3↑, 106,   cl‑Casp3↑, 15,   proCasp3↓, 1,   proCasp3↑, 1,   Casp7?, 1,   Casp7↑, 12,   cl‑Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 22,   cl‑Casp8↑, 3,   pro‑Casp8↑, 1,   Casp9?, 1,   Casp9↑, 63,   cl‑Casp9↑, 6,   proCasp9↓, 1,   cFLIP↓, 9,   Cyt‑c↑, 44,   mt-Cyt‑c↓, 1,   Diablo↑, 5,   DR5↓, 1,   DR5↑, 22,   FADD↑, 3,   Fas↓, 1,   Fas↑, 15,   FasL↑, 3,   Ferroptosis↑, 12,   GranB/GZMB↑, 1,   GranB/GZMB↝, 1,   HEY1↓, 1,   IAP1↓, 8,   IAP2/BIRC3↓, 5,   ICAD↓, 1,   iNOS↓, 13,   iNOS↑, 1,   Mcl-1↓, 27,   Mcl-1↑, 2,   MDM2↓, 8,   p‑MDM2↓, 1,   MOMP↓, 1,   MOMP↑, 2,   Necroptosis↑, 1,   necrosis↑, 2,   NOXA↑, 3,   p38↓, 5,   p38↑, 16,   p‑p38↓, 3,   p‑p38↑, 6,   Perforin↑, 1,   Perforin↝, 1,   PUMA↑, 4,   Pyro↑, 1,   survivin↓, 67,   TNFR 1↑, 1,   TRAIL↑, 3,   TRAILR↑, 1,   TumCD?, 1,   TumCD↑, 12,   XIAP?, 1,   XIAP↓, 25,   XIAP↑, 1,   YAP/TEAD↓, 3,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 115,   Akt↑, 4,   Akt↝, 1,   p‑Akt↓, 31,   AMPKα↓, 1,   AMPKα↑, 1,   Brk/PTK6↓, 1,   CaMKII ↓, 2,   p‑CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 4,   cMET↓, 6,   p‑cMET↑, 1,   cSrc↓, 8,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 36,   EGFR↑, 1,   p‑EGFR↓, 3,   EphB4↓, 1,   ERK↓, 42,   ERK↑, 6,   ERK↝, 2,   p‑ERK↓, 18,   FGFR1↓, 2,   FGFR2↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   HGF/c-Met↝, 1,   Hippo↓, 1,   IGF-1R↓, 6,   IGFR↓, 2,   IKKα↓, 7,   p‑IKKα↓, 1,   IR↓, 2,   IκB↑, 1,   JAK↓, 18,   JAK↝, 1,   p‑JAK↓, 1,   JAK1?, 1,   JAK1↓, 18,   JAK1↑, 2,   p‑JAK1↓, 3,   JAK2↓, 54,   p‑JAK2↓, 9,   p‑JAK3↓, 2,   JNK↓, 2,   JNK↑, 21,   p‑JNK↓, 1,   p‑JNK↑, 3,   LIFR/CD118↓, 1,   LIMK1↓, 1,   MAPK↓, 20,   MAPK↑, 15,   MAPK↝, 1,   p‑MAPK↓, 2,   p‑MAPK↑, 1,   MARK4↓, 1,   MEK↓, 5,   MKK4↓, 1,   mTOR↓, 73,   mTOR↝, 1,   p‑mTOR↓, 10,   mTORC2↓, 1,   P70S6K↓, 3,   p‑P70S6K↓, 2,   P90RSK↓, 2,   p‑P90RSK↑, 1,   PAK↓, 1,   PDGFR-BB↓, 1,   PDGFR-BB↑, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 76,   PI3K↑, 3,   PI3K↝, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 2,   PIAS-3↑, 1,   PKA↓, 2,   PKCδ↓, 4,   PP2A↑, 1,   PRAS40↓, 1,   PTEN↓, 1,   PTEN↑, 26,   PTPN6↑, 2,   Raf↓, 3,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 8,   RAS↑, 1,   RET↓, 1,   p‑S6K↓, 1,   SHP1↓, 1,   SHP1↑, 7,   Sp1/3/4↓, 14,   Src↓, 5,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 5,   p‑STAT2↓, 1,   STAT3↓, 321,   STAT3↑, 13,   STAT3⇅, 1,   STAT3↝, 3,   p‑STAT3↓, 74,   p‑STAT3↑, 4,   i-STAT3↓, 1,   mt-STAT3↓, 1,   STAT4↓, 2,   STAT4↑, 1,   STAT5↓, 8,   p‑STAT5↓, 1,   STAT6↓, 2,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   TK1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 4,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 3,   cJun↑, 3,   cMyc↓, 50,   DNMT1↓, 9,   DNMT3A↓, 2,   DNMTs↓, 4,   EZH2↓, 2,   FOXM1↓, 6,   FOXO↓, 1,   FOXO↑, 1,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 3,   FOXO3↑, 5,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   GATA3↓, 1,   GATA3↑, 1,   H3↓, 1,   H3↑, 2,   p‑H3↓, 2,   ac‑H3↑, 2,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 2,   HATs↓, 5,   HATs↑, 2,   HDAC↓, 18,   HDAC1↓, 3,   HDAC10↓, 1,   HDAC2↓, 3,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC8↓, 3,   HES1↓, 1,   IRF1↑, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-134↑, 1,   miR-139-5p↑, 1,   miR-148a↓, 1,   miR-148a↑, 1,   miR-149↑, 1,   miR-155↓, 3,   miR-182-5p↓, 1,   miR-19b↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-203↑, 1,   miR-205↑, 1,   miR-21↓, 7,   miR-218↑, 1,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-29b↓, 1,   miR-301a-3p↓, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 2,   miR-422a↑, 1,   miR-592↑, 1,   Myc↓, 6,   MYCN↓, 1,   n-MYC↓, 1,   NDRG1↑, 1,   NNMT↓, 1,   OCT4↓, 13,   other↓, 3,   other↑, 1,   other↝, 5,   PAX2↓, 1,   PCAF↓, 1,   SOX2↓, 12,   SOX4↓, 2,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   SUV39H↓, 2,   TFE3↑, 1,   tumCV↓, 49,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 18,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 2,   eIF2α↑, 2,   p‑eIF2α↑, 5,   ER Stress↑, 31,   Erlin1↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 8,   HSP27↓, 3,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 15,   PERK↑, 4,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↑, 5,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 4,   ATG7↑, 2,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 11,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B-II↑, 1,   LC3II↓, 2,   LC3II↑, 9,   LC3s↑, 1,   MitoP↓, 1,   p62↓, 7,   SESN2↑, 2,   TumAuto↑, 24,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↓, 2,   BRCA1↑, 1,   BRCA2↑, 1,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 37,   DNArepair↓, 2,   DNArepair↑, 1,   hTERT/TERT↓, 9,   NKX3.1↑, 1,   p16↑, 3,   P53?, 1,   P53↓, 3,   P53↑, 65,   P53↝, 2,   p‑P53↓, 1,   i-P53↓, 1,   PARP↓, 1,   PARP↑, 15,   cl‑PARP↑, 58,   proPARP↓, 1,   PARP1↑, 3,   cl‑PARP1↑, 1,   PCNA↓, 23,   SIRT6↓, 2,   SIRT6↑, 1,   Telomerase↓, 9,   TOP1↓, 7,   TOP2↓, 4,   TOP2↑, 1,   TP53↓, 1,   TP53↑, 2,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 6,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 14,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 28,   CDK4↓, 32,   CDK4↑, 1,   CDK6↓, 11,   CDK6↑, 1,   CDK8↓, 2,   CDKN1C/p57↑, 1,   CHK1↓, 4,   CHK1↑, 1,   Chk2↓, 3,   Chk2↑, 1,   cycA1/CCNA1↓, 7,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 21,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 91,   cycD1/CCND1↑, 1,   CycD3↓, 3,   cycE/CCNE↓, 15,   cycE1↓, 1,   E2Fs↓, 4,   E2Fs↑, 1,   GADD45A↑, 1,   Ki-67↓, 26,   P21?, 1,   P21↓, 4,   P21↑, 46,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 20,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 6,   TumCCA↓, 4,   TumCCA↑, 150,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4,   ALDH1A1↓, 3,   Axin2↑, 1,   BMPs↑, 1,   CD133↓, 10,   CD24↓, 1,   CD34↓, 2,   cFos↓, 5,   cFos↑, 1,   CSCs↓, 42,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↓, 2,   Diff↑, 1,   EIF4E↓, 2,   FGF↓, 3,   Gli↓, 1,   Gli1↓, 5,   HH↓, 5,   HMGCR↓, 1,   IGF-1↓, 4,   IGFBP1↑, 1,   IGFBP3↑, 1,   IGFBP7↑, 1,   JAG1↓, 1,   Ki-67↓, 26,   Let-7↑, 3,   LRP6↓, 1,   MSCmark↓, 1,   mTORC1↓, 4,   p‑mTORC1↓, 1,   Nanog↓, 13,   Nestin↓, 5,   NOTCH↓, 19,   NOTCH⇅, 1,   NOTCH1↓, 12,   NOTCH1↑, 3,   NOTCH1↝, 1,   NOTCH2↓, 1,   NOTCH3↓, 2,   p300↓, 2,   Piezo1↑, 1,   PTCH1↓, 3,   SCF↓, 1,   Shh↓, 8,   Smo↓, 3,   STAT1↓, 3,   p‑STAT1↓, 1,   TumCG?, 2,   TumCG↓, 74,   TumCG↑, 3,   TumCP?, 2,   TumCP↓, 120,   TumCP↑, 2,   tyrosinase↓, 1,   Wnt↓, 37,   Wnt↑, 1,   Wnt/(β-catenin)↓, 6,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 14,   AP-1↑, 1,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 2,   CA↓, 2,   Ca+2↑, 16,   Ca+2↝, 2,   CAFs/TAFs↓, 1,   cal2↓, 1,   CD11b↓, 1,   Cdc42↓, 1,   Chl↑, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 8,   E-cadherin↑, 37,   EM↑, 1,   EMT↓, 68,   EMT↑, 2,   FAK↓, 16,   FAK↑, 1,   p‑FAK↓, 4,   fascin↓, 1,   Fibronectin↓, 2,   GIT1↓, 1,   GLI2↓, 1,   ITGA2↓, 1,   ITGA5↓, 3,   ITGA6↓, 1,   ITGB1↓, 3,   ITGB3↓, 1,   ITGB4↓, 1,   KRAS↓, 2,   LAMs↓, 2,   LEF1↓, 2,   MALAT1↓, 2,   MET↓, 3,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 3,   MMP15↓, 1,   MMP16↓, 1,   MMP2?, 1,   MMP2↓, 82,   MMP2↑, 1,   MMP3↓, 4,   MMP7↓, 8,   MMP9?, 1,   MMP9↓, 90,   MMP9↑, 2,   MMP9:TIMP1↓, 1,   MMPs↓, 24,   MUC4↓, 1,   N-cadherin↓, 25,   PAK1↓, 2,   PDGF↓, 4,   Rac1↓, 1,   Rho↓, 5,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 12,   Smad1↓, 2,   Smad1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   Snail?, 1,   Snail↓, 24,   TET1↑, 2,   TGF-β↓, 15,   TGF-β↑, 1,   TIMP1↓, 2,   TIMP1↑, 3,   TIMP2↓, 2,   TIMP2↑, 4,   TRIB3↑, 2,   TSP-1↑, 3,   TumCI↓, 73,   TumCI↑, 1,   TumCMig↓, 70,   TumCMig↑, 1,   TumMeta↓, 52,   TumMeta↑, 8,   Twist↓, 22,   Tyro3↓, 1,   uPA↓, 14,   uPAR↓, 1,   Vim↓, 31,   Vim↑, 1,   Zeb1↓, 10,   ZEB2↓, 2,   α-SMA↓, 3,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 52,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 69,   angioG↑, 3,   CD31/PECAM-1↓, 4,   ECM/TCF↓, 1,   Endoglin↑, 1,   eNOS↑, 1,   HIF-1↓, 5,   Hif1a↓, 57,   Hif1a↝, 2,   Hypoxia↓, 1,   NO↓, 5,   NO↑, 3,   NO↝, 1,   PHDs↓, 1,   VCAM-1↓, 1,   VEGF↓, 109,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 15,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 7,   CLDN1↓, 4,   CLDN1↑, 1,   CLDN2↓, 2,   EPR↑, 3,   GLUT1↓, 10,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 3,   IBI↑, 1,   MMP?, 1,   MMP↓, 67,   MMP↑, 1,   MMP↝, 1,   MPT↑, 3,   NHE1↓, 2,   OCLN↑, 1,   TJ↑, 1,   TRPV1↑, 3,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ALC∅, 1,   CB2 / CNR2↓, 1,   CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 2,   CD44↓, 10,   CD8+↑, 2,   COX1↓, 3,   COX2/PTGS2↓, 69,   COX2/PTGS2↑, 2,   CXCL1↓, 1,   CXCL12↓, 2,   CXCR2↓, 1,   CXCR4↓, 14,   CXCR4↑, 1,   DR4↑, 7,   FOXP3↓, 2,   Gal-3↓, 2,   HCAR1↓, 1,   HMGB1↓, 1,   ICAM-1↓, 6,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 4,   IL1↑, 1,   IL10↓, 8,   IL10↑, 1,   IL12↓, 2,   IL18↓, 2,   IL1α↓, 2,   IL1β↓, 11,   IL2↓, 2,   IL2↑, 4,   IL4↓, 2,   IL4↑, 2,   IL5↓, 1,   IL6↓, 64,   IL6↑, 1,   IL7↓, 1,   IL8↓, 10,   Imm↑, 6,   Imm↝, 2,   Inflam↓, 33,   M2 MC↓, 3,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 4,   MCT1↓, 3,   MIP2↓, 2,   NF-kB↓, 130,   NF-kB↑, 4,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 1,   NK cell↑, 4,   NLRP3↓, 5,   NLRP3↑, 2,   p65↓, 8,   p‑p65↓, 2,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 15,   PGE2↓, 15,   PSA↓, 4,   PSA∅, 1,   RAGE↓, 1,   RANTES↓, 1,   SOCS-3↓, 1,   SOCS-3↑, 2,   SOCS1↑, 1,   T-Cell↑, 2,   TCF↓, 1,   TCF7/TCF1↓, 1,   Th1 response↑, 1,   Th17↓, 1,   TLR2↓, 1,   TLR4↓, 3,   TNF-α↓, 32,   TNF-α↑, 4,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   pH↓, 1,   pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AR↓, 16,   AR↑, 1,   ER-α36↓, 2,   ER(estro)↓, 1,   GR↑, 1,   PPARα↓, 2,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 8,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 35,   BioAv↑, 33,   BioAv↝, 7,   BioEnh↑, 3,   chemoR↓, 1,   ChemoSen↓, 1,   ChemoSen↑, 110,   ChemoSen⇅, 1,   CompStab↓, 3,   CompStab↝, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1B1↑, 1,   Dose?, 3,   Dose↓, 2,   Dose↑, 6,   Dose↝, 34,   Dose∅, 11,   eff?, 1,   eff↓, 28,   eff↑, 55,   eff↝, 6,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 14,   Half-Life↑, 1,   Half-Life↝, 11,   MDR1↓, 5,   MRP1/ABCC1↓, 4,   NAT↓, 1,   P-gp/ABCB1↓, 13,   P-gp/ABCB1↝, 1,   P450↓, 2,   RadioS↑, 39,   selectivity↑, 46,   selectivity∅, 1,   Synergy↑, 81,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↑, 1,   ALAT↓, 4,   ALAT↝, 1,   ALP↓, 2,   ALP↝, 1,   AR↓, 16,   AR↑, 1,   ascitic↓, 2,   AST↓, 3,   AST↝, 1,   BRCA1↓, 2,   BRCA1↑, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 3,   E7↓, 3,   EGFR↓, 36,   EGFR↑, 1,   p‑EGFR↓, 3,   EZH2↓, 2,   FOXM1↓, 6,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 9,   IL6↓, 64,   IL6↑, 1,   KRAS↓, 2,   LDH↓, 5,   LDH↝, 1,   Myc↓, 6,   NSE↓, 1,   PD-L1↓, 15,   PSA↓, 4,   PSA∅, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TP53↓, 1,   TP53↑, 2,   TRIB3↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 29,   antiD↑, 1,   antiNeop↑, 5,   AntiTum↓, 1,   AntiTum↑, 8,   cachexia↓, 4,   cardioP↑, 9,   CardioT↑, 1,   chemoP↑, 19,   chemoPv↑, 17,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↓, 1,   hepatoP↑, 6,   K17↓, 1,   neuroP↑, 7,   NKG2D↑, 1,   Obesity↓, 2,   OS↑, 7,   Pain↓, 2,   QoL↑, 4,   radioP↑, 6,   RenoP↑, 4,   Risk↓, 3,   Strength↑, 1,   toxicity↓, 15,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 7,   toxicity∅, 1,   TumVol↓, 21,   TumVol∅, 1,   TumW↓, 13,   TumW∅, 1,   Weight↑, 1,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   Bacteria↓, 1,   GutMicro↑, 6,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 3,  
Total Targets: 982

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 3,   antiOx↑, 52,   ARE↑, 2,   Catalase↑, 29,   DUOX1↓, 1,   Fenton↓, 1,   GPx↑, 18,   GPx4↑, 1,   GSH↑, 28,   GSR↑, 1,   GSTs↑, 10,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 1,   HNE↑, 1,   HO-1↑, 16,   i-Iron↓, 1,   Keap1↓, 2,   lipid-P↓, 17,   MDA↓, 22,   MPO↓, 4,   MPO↑, 1,   NOX↓, 1,   NOX2↓, 1,   NOX4↓, 3,   NQO1↑, 4,   NRF2?, 1,   NRF2↓, 2,   NRF2↑, 29,   Prx↑, 1,   RNS↓, 1,   ROS?, 3,   ROS↓, 67,   SOD↑, 36,   SOD1↑, 3,   SOD2↑, 2,   TAC↑, 2,   TBARS↓, 3,   TOS↓, 1,   uricA↓, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 2,   PINK1↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 1,   ACC↓, 1,   ALAT↓, 8,   AMPK↓, 1,   AMPK↑, 6,   ATP↓, 1,   ATP↑, 1,   Buty↑, 1,   CRM↑, 1,   FASN↓, 2,   GSK‐3β↓, 1,   H2S↑, 1,   LDL↓, 2,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 2,   NADPH↑, 3,   PLA2↓, 1,   SCFAs↑, 1,   SIRT1↑, 5,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 3,   Bcl-2↓, 2,   Bcl-2↑, 3,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp1↓, 1,   Casp3?, 1,   Casp3↓, 7,   Casp9↓, 4,   Cyt‑c↓, 1,   Ferroptosis↓, 1,   GSDMD↓, 1,   iNOS↓, 13,   p38↓, 2,   p38↑, 1,   p‑p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 5,   Akt↝, 1,   p‑Akt↑, 1,   AKT1↓, 1,   EGFR↓, 1,   ERK↓, 2,   ERK↑, 1,   IKKα↑, 1,   IκB?, 1,   JAK↓, 2,   p‑JAK1↓, 1,   JAK2↓, 3,   JAK2↑, 4,   p‑JAK2↓, 2,   JNK↓, 2,   p‑JNK↓, 2,   LPAR1/EDG2↑, 1,   MAPK↓, 9,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 1,   mTOR↑, 3,   PI3K↓, 3,   PI3K↑, 5,   PTEN↑, 1,   STAT↓, 1,   STAT3?, 1,   STAT3↓, 18,   STAT3↑, 6,   STAT3↝, 1,   p‑STAT3↓, 4,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 3,   HDAC2↓, 1,   HOTAIR↑, 1,   OCT4↓, 1,   other↑, 2,   other↝, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   p‑eIF2α↓, 1,   ER Stress↓, 4,   GRP78/BiP↓, 2,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   IRE1↓, 1,   p‑PERK↓, 1,   UPR↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↓, 1,   autophagy↓, 1,   Beclin-1/ATG6↓, 3,   LC3B↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   Ki-67↓, 2,   P21↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↓, 2,   neuroG↑, 2,   p300↓, 1,   p‑STAT1↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   Ca+2↓, 1,   Ca+2↝, 1,   COL1↓, 1,   COL1↑, 1,   Fibrosis↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 4,   p‑Rac1↓, 1,   ROCK1↓, 1,   Sema3A/PlexinA1↑, 1,   p‑SMAD2↓, 1,   SPARC↓, 1,   TGF-β↓, 1,   TGF-β↑, 2,   TGF-β1↓, 1,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TXNIP↓, 1,   α-SMA↓, 4,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   CD31/PECAM-1↓, 1,   eNOS↑, 1,   NO↓, 12,   NO↑, 3,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   BBB∅, 2,   IBI↑, 1,   MMP↑, 4,   OATPs↓, 1,   TJ↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 17,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 3,   IFN-γ↓, 4,   IL1↓, 1,   IL10↓, 4,   IL10↑, 4,   IL17↓, 5,   IL18↓, 2,   IL1β↓, 23,   IL2↓, 3,   IL22↓, 3,   IL23↓, 1,   IL4↓, 3,   IL4↑, 1,   IL5↓, 2,   IL6↓, 25,   IL8↓, 5,   Imm↓, 1,   Imm↑, 1,   Imm⇅, 1,   Inflam↓, 65,   Inflam↑, 2,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   NeuroI↓, 1,   NF-kB↓, 30,   NF-kB↑, 1,   NLRP3↓, 7,   NLRP3↑, 1,   PGE2↓, 12,   PGE2↑, 1,   PSA↓, 1,   RAGE↓, 2,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 1,   TLR4↓, 3,   TNF-α↓, 33,   TNF-α↑, 1,   Treg lymp↝, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   BDNF↓, 1,   BDNF↑, 1,   GABA↑, 1,   PSD95↑, 1,   SNAP25↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 9,   BACE/β-secretase↓, 2,   tau↓, 2,   p‑tau↓, 1,   XO↓, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   DHT↓, 1,   GLP-1R↑, 1,   GR↑, 1,   PPARα↑, 1,   PPARγ↑, 1,   p‑PPARγ↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 29,   BioAv↑, 13,   BioAv↝, 12,   BioEnh↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 9,   eff↑, 7,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↑, 1,   Half-Life↝, 9,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↑, 1,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 8,   ALP↓, 1,   AST↓, 9,   BG↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 2,   creat↓, 2,   CRP↓, 1,   EGFR↓, 1,   IL6↓, 25,   LDH↓, 2,   NOS2↓, 1,   PSA↓, 1,   RAGE↓, 2,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 1,   antiAll↑, 14,   AntiArt↑, 4,   AntiCan↓, 1,   AntiCan↑, 10,   AntiDiabetic↑, 7,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 3,   cardioP↑, 18,   chemoP↑, 3,   chemoPv↑, 2,   cognitive↑, 9,   diuretic↑, 3,   hepatoP↑, 30,   Learn↑, 2,   memory↑, 10,   motorD↑, 1,   Mucositis↓, 2,   neuroP↑, 41,   Obesity↓, 2,   OS↑, 2,   radioP↑, 2,   RenoP↑, 6,   Stroke↓, 4,   toxicity↓, 16,   toxicity↑, 1,   toxicity↝, 5,   toxicity∅, 5,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↓, 1,   AntiP↑, 1,   AntiViral↑, 10,   Bacteria↓, 8,   GutMicro↑, 9,   GutMicro↝, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 340

Scientific Paper Hit Count for: STAT3, Signal transducer and activator of transcription 3
27 Curcumin
15 Thymoquinone
13 Cucurbitacin
13 Quercetin
12 Apigenin (mainly Parsley)
12 Luteolin
10 Resveratrol
9 EGCG (Epigallocatechin Gallate)
9 Baicalein
9 Capsaicin
9 Chrysin
9 Garcinol
9 Honokiol
8 Ashwagandha(Withaferin A)
8 Betulinic acid
8 Emodin
8 Ginkgetin
8 Silymarin (Milk Thistle) silibinin
7 Lycopene
6 Berberine
6 brusatol
6 Kaempferol
5 Artemisinin
5 Beta-Caryophyllene
5 Caffeic acid
5 Matrine
5 Pterostilbene
4 Cisplatin
4 Radiotherapy/Radiation
4 Berbamine
4 Sorafenib (brand name Nexavar)
4 Carnosic acid
4 Celastrol
4 Cynaropicrin
4 Ellagic acid
4 Fisetin
4 Formononetin
4 Sulforaphane (mainly Broccoli)
4 Ginger/6-Shogaol/Gingerol
4 HydroxyTyrosol
4 Isoliquiritigenin
4 Ivermectin
4 Magnolol
4 Morin
4 Niclosamide (Niclocide)
4 Piperine
4 Piperlongumine
3 Gemcitabine (Gemzar)
3 Melatonin
3 Chemotherapy
3 Boswellia (frankincense)
3 Propolis -bee glue
3 Magnetic Fields
3 chaetocin
3 Dandelion Root
3 Gambogic Acid
3 Paclitaxel/Taxol
3 isoorientin
3 lambertianic acid
3 Licorice
3 Methylsulfonylmethane
3 Nimbolide
3 Oleocanthal
3 Phenethyl isothiocyanate
3 Rosmarinic acid
3 Shikonin
3 Ursolic acid
2 Andrographis
2 Ascorbyl Palmitate
2 Arctigenin
2 Baicalin
2 Brucea javanica
2 borneol
2 Boron
2 Centella asiatica / Gotu kola → asiaticoside
2 Cinnamon
2 immunotherapy
2 methylseleninic acid
2 Fucoidan
2 Gallic acid
2 Genistein (soy isoflavone)
2 Geraniol
2 Indole-3-carbinol
2 Juglone
2 Lasiodin
2 Licochalcone A
2 Modified Citrus Pectin
2 Metformin
2 Vitamin C (Ascorbic Acid)
2 Sanguinarine
2 Vitamin K2
1 5-Hydroxytryptophan
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Astaxanthin
1 Biochanin A
1 Atorvastatin
1 Bufalin/Huachansu
1 Brutieridin–Melitidin Mixture
1 Black Rice, Oryza sativa
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carvacrol
1 Trastuzumab
1 Hydroxycinnamic-acid
1 Crocetin
1 Carvone
1 Oxygen, Hyperbaric
1 CUSP9
1 Deguelin
1 D-limonene
1 Tetrahydroxystilbene glucoside
1 Ferulic acid
1 Ginkgolic acids
1 Ginseng
1 Hydrogen Gas
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 Hyperoside
1 Isobavachalcone
1 Inositol
1 isoflavones
1 isoquercitrin
1 L-Theanine
1 Lactoferrin/Talactoferrin
1 Lemongrass Extract/Citral
1 mebendazole
1 Moringa oleifera
1 doxorubicin
1 tamoxifen
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Shiitake, AHCC
1 Naringin
1 Oleuropein
1 Orlistat
1 Marjoram (Origanum majorana)
1 Plumbagin
1 VitK3,menadione
1 Parthenolide
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Urolithin
1 Usnic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:373  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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