Akt Cancer Research Results

Akt, PKB-Protein kinase B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes; Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport.

Inhibitors:
-Curcumin: downregulate AKT phosphorylation and signaling.
-Resveratrol
-Quercetin: inhibit the PI3K/AKT pathway.
-Epigallocatechin Gallate (EGCG)
-Luteolin and Apigenin: inhibit AKT phosphorylation


Scientific Papers found: Click to Expand⟱
1184- DHA,    Syndecan-1-Dependent Suppression of PDK1/Akt/Bad Signaling by Docosahexaenoic Acid Induces Apoptosis in Prostate Cancer
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vivo, NA, NA
SDC1↑, p‑PCK1↓, Akt↓, BAD↓,
1844- dietFMD,    Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment
- Review, NA, NA
Risk↓, AMPK↑, Akt↓, mTOR↓, SIRT1↑, Hif1a↓, NRF2↓, SOD↑, ROS↑, IGF-1↓, p‑Akt↓, PI3K↑, GutMicro↑, OS↑, eff↝, ROS↑, TumCCA↑, *DNArepair↑, DNAdam↑,
1854- dietFMD,    How Far Are We from Prescribing Fasting as Anticancer Medicine?
- Review, Var, NA
ChemoSideEff↓, ChemoSen↑, IGF-1↓, IGFBP1↑, adiP↑, glyC↓, E-cadherin↑, MMPs↓, Casp3↑, ROS↑, ATP↓, AMPK↑, mTOR↓, ROS↑, Glycolysis↓, NADPH↓, OXPHOS↝, eff↑, eff↑, *RAS↓, *MAPK↓, *PI3K↓, *Akt↓, eff↑, ROS↑, Akt↑, Casp3↑,
1860- dietFMD,  Chemo,    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
- in-vitro, BC, SUM159 - in-vitro, BC, 4T1
PI3K↑, Akt↑, mTOR↑, CDK4↑, CDK6↑, hyperG↓, TumCG↓, TumVol↓, Casp3↑, BG↓, eff↑, eff∅, PKA↓, KLF5↓, p‑GSK‐3β↑, Nanog↓, OCT4↓, KLF2↓, eff↑, ROS↑, BIM↑, ASK1↑, PI3K↑, Akt↑, mTOR↑, CDK1↓, CDK4↑, CDK6↑, eff↑,
2269- dietMet,    Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice
- in-vivo, Nor, NA
*adiP↑, *FGF↑, *Insulin↓, *glucose↓, *Akt↑, *GSH↓, *PTEN↓, *FGF21↑, *PIP3↑,
2263- dietMet,    Methionine Restriction and Cancer Biology
- Review, Var, NA
AntiCan↑, TumCP↓, TumCG↓, selectivity↑, ChemoSen↓, RadioS↑, Insulin↓, *GlucoseCon↑, *ROS↓, *antiOx↑, *GSH↑, GSH↑, eff↑, polyA↓, TS↓, Raf↓, Akt↓, Casp9↑, Bak↑, P21↑, p27↑, Insulin↓, IGF-1↓,
4987- Dipy,  ATV,    Enhanced cardioprotection against ischemia-reperfusion injury with a dipyridamole and low-dose atorvastatin combination
- in-vivo, Nor, NA
*cardioP↑, *Akt↑, *eNOS↑,
6269- DL,    Induction of apoptosis by D-limonene is mediated by inactivation of Akt in LS174T human colon cancer cells
- in-vitro, CRC, LS174T
tumCV↓, Apoptosis↑, Casp3↑, Casp9↑, cl‑PARP↑, BAX↑, Cyt‑c↑, Bcl-2↓, PI3K↓, Akt↓,
6287- DL,    D-Limonene Is a Potential Monoterpene to Inhibit PI3K/Akt/IKK-α/NF-κB p65 Signaling Pathway in Coronavirus Disease 2019 Pulmonary Fibrosis
- in-vivo, Covid, NA
*PI3K↓, *Akt↓, *NF-kB↓,
6342- DRE,    Mechanistic Study on the Inhibitory Effect of Dandelion Extract on Breast Cancer Cell Proliferation and Its Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
eff↑, selectivity↑, Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, JAK1↓, STAT↓, PPARγ↑, TumCP↓, SIRT6↓, SCD1↓, STAT3↓, Casp8↓, STAT6↓, PAK1↓, FABP4↓,
6343- DRE,    Dandelion root extract affects ESCC progression via regulating multiple signal pathways
- vitro+vivo, ESCC, NA
*Inflam↓, TumCG↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↓, TumCG↓, PI3K↓, p‑Akt↓, RAS↓, Raf↓, p‑ERK↓, Bcl-2↓, BAX↑,
6348- DRE,    New prospects in oncotherapy: bioactive compounds from Taraxacum officinale
- Review, Var, NA
Dose↝, TumCP↓, toxicity↓, *AntiDiabetic↑, *antiOx↑, *hepatoP↑, *diuretic↑, *Inflam↓, *neuroP↑, *Imm↑, eff↑, Apoptosis↑, tumCV↓, selectivity↑, TumCMig↓, EMT↓, MMP2↓, MMP9↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, JNK↓, ERK↓,
6354- DRE,    Taraxacum officinale L. in leukemia and lymphoma: current knowledge and prospects for horticulture
- Review, AML, NA
ROS↑, mt-Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, STAT3↓, Dose↝, *hepatoP↑, Casp8↑, mtDam↑, TumCD↑, selectivity↑, DNAdam↑, BAX↑, P53↑, Bcl-2↓, CSCs↓, *toxicity↓, tumCV↓, Imm↑, FAK↓, mTOR↓, ChemoSen↑, eff↝, eff↑,
6359- DRE,    Natural Health Products (NHP’s) and Natural Compounds as Therapeutic Agents for the Treatment of Cancer; Mechanisms of Anti-Cancer Activity of Natural Compounds and Overall Trends
- Review, Var, NA
*antiOx↑, *Inflam↓, Dose↝, PI3K↓, Akt↓, NF-kB↓,
6360- DRE,    Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma
- in-vitro, ESCC, KYSE450 - in-vitro, ESCC, Eca109
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, survivin↓, Bax:Bcl2↑, Casp3↑, Casp9↑, MMP2↓, MMP9↓, VEGF↓, EMT↓, eff↑, DNAdam↑, p‑STAT3↑, ChemoSen↑,
5012- DSF,  Cu,    Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems
ROS↑, ALDH↓, TumCP↓, CSCs↓, angioG↓, TumMeta↓, DNAdam↑, Proteasome↓, SOD1↓, GSR↓, ox-GSSG↑, GSH/GSSG↓, MMP↓, Akt↓, cycD1/CCND1↓, NF-kB↓, CSCs↓, MAPK↓, angioG↓, DrugR↓, EMT↓, Vim↓, BioAv↑, eff↑,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
1606- EA,    Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells
- in-vitro, Colon, HCT15
TumCP↓, cycD1/CCND1↓, Apoptosis↑, PI3K↓, Akt↓, ROS↑, Casp3↑, Cyt‑c↑, Bcl-2↓, TumCCA↑, Dose∅, ALP↓, LDH↓, PCNA↓, P53↑, Bax:Bcl2↑,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
1610- EA,    Anticancer Effect of Pomegranate Peel Polyphenols against Cervical Cancer
- Review, Cerv, NA
TumCCA↑, STAT3↓, P21↑, IGFBP7↑, Akt↓, mTOR↓, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑,
1618- EA,    A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
- Review, BC, NA
TumCCA↑, TumCMig↓, TumCI↓, TumMeta↓, Apoptosis↑, TGF-β↓, SMAD3↓, CDK6↓, PI3K↓, Akt↓, angioG↓, VEGFR2↓, MAPK↓, NEDD9↓, NF-kB↓, eff↑, eff↑, RadioS↑, ChemoSen↑, DNAdam↑, eff↑, *toxicity∅, *toxicity∅,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, PANC1
HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2↓, Hif1a↓, VEGF↓, VEGFR2↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,
1036- EGCG,    Green Tea Catechin Is an Alternative Immune Checkpoint Inhibitor that Inhibits PD-L1 Expression and Lung Tumor Growth
- in-vitro, Lung, A549 - in-vitro, Lung, LU99
PD-L1↓, EGF↓, Akt↓,
20- EGCG,    Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer
- in-vivo, Liver, NA - in-vivo, Tong, NA
HH↓, Gli1↓, Smo↓, TNF-α↓, COX2↓, *antiOx↑, Hif1a↓, NF-kB↓, VEGF↓, STAT3↓, Bcl-2↓, P53↑, Akt↓, p‑Akt↓, p‑mTOR↓, EGFR↓, AP-1↓, BAX↑, ROS↑, Casp3↑, Apoptosis↑, NRF2↑, *H2O2↓, *NO↓, *SOD↑, *Catalase↑, *GPx↑, *ROS↓,
692- EGCG,    EGCG: The antioxidant powerhouse in lung cancer management and chemotherapy enhancement
- Review, NA, NA
ROS↑, Apoptosis↑, DNAdam↑, CTR1↑, JWA↑, β-catenin/ZEB1↓, P53↑, Vim↓, VEGF↓, p‑Akt↓, Hif1a↓, COX2↓, ERK↓, NF-kB↓, Akt↓, Bcl-xL↓, miR-210↓,
688- EGCG,  GEM,    Akt_Pathway_and_Epithelial-Mesenchymal_Transition_Enhanced_Efficacy_whe">Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial–Mesenchymal Transition: Enhanced Efficacy When Combined with Gemcitabine
- in-vitro, PC, NA
Zeb1↓, β-catenin/ZEB1↓, Vim↓, Akt↓, p‑IGFR↓, TumCG↓, TumCMig↓, TumCI↓,
684- EGCG,    Improving the anti-tumor effect of EGCG in colorectal cancer cells by blocking EGCG-induced YAP activation
- in-vitro, CRC, NA
eff↑, Akt↓, VEGFR2↓, STAT3↓, P53↓, Hippo↓, YAP/TEAD↑,
680- EGCG,    Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
- Review, NA, NA
NF-kB↓, STAT3↓, PI3K↓, HGF/c-Met↓, Akt↓, ERK↓, MAPK↓, AR↓, Casp↑, Ki-67↓, PARP↑, Bcl-2↓, BAX↑, PCNA↓, p27↑, P21↑,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, eff↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
2459- EGCG,    Epigallocatechin gallate inhibits human tongue carcinoma cells via HK2‑mediated glycolysis
- in-vitro, Tong, Tca8113 - in-vitro, Tong, TSCCa
EGFR↓, Akt↓, ERK↓, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓,
988- EMD,    Emodin Induced Necroptosis and Inhibited Glycolysis in the Renal Cancer Cells by Enhancing ROS
- in-vitro, RCC, NA
Necroptosis↑, p‑RIP1↑, MLKL↑, ROS↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, eff↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6820- EMD,    The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update
- Review, Nor, NA - Review, Arthritis, NA - Review, AD, NA
*diuretic↑, *Bacteria↓, *Inflam↓, AntiCan↑, TumCP↓, TumCI↓, angioG↓, *toxicity↓, IFN-γ↑, IL12↑, ROS↑, TNF-α↓, TNF-α↓, TGF-β↓, MAPK↓, PKCδ↓, NF-kB↓, HER2/EBBR2↓, VEGF↓, DNAdam↑, Necroptosis↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓, Casp9↑, Casp3↑, BAX↑, Bcl-2↓, eff↑, MMP2↓, MMP9↓, eff↑, ChemoSen↑, P-gp↓, SREBP2↓, eff↑, *other↝, *COX2↓, *Hif1a↓, *HDAC↓, *tau↓, *PKCδ↑, *ROS↓, *Inflam↓, AntiAg?,
6823- EMD,    Role of emodin to prevent gastrointestinal cancers: recent trends and future prospective
- Review, Var, NA
AntiCan↑, *antiOx↑, *chemoP↑, *Inflam↓, TumCP↓, TumMeta↓, TumCCA↑, MAPK↑, BAX↑, Casp↑, ROS↑, *BioAv↓, other↝, TumCI↓, EMT↓, TumCG↑, Apoptosis↑, TumCP↑, MMP2↓, Casp3↑, ChemoSen↑, PI3K↓, Akt↓, Cyt‑c↑, cl‑PARP↑, MMP↓, Warburg↓, HK2↓, PKM2↓, LDHA↓, mtDam↑, Apoptosis↑, N-cadherin↓, Vim↓, E-cadherin↑, eff↑, eff↑, eff↑, toxicity↝, toxicity↑,
6824- EMD,    Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer’s Dementia: A Systematic Review
- Review, AD, NA
*Inflam?, *antiOx↑, *tau↓, *Aβ↓, *neuroP↑, *ROS↓, *memory↑, *cognitive↑, *other↝, *AChE↓, *BACE↓, *LC3II↓, *Beclin-1↓, *p‑tau↓, *CREB↑, *HNE↓, *BioAv↓, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, BioAv↑, *HO-1↑, *PKCδ↑, *Akt↑, *NLRP3↓, *NF-kB↓, *TLR3↓,
5225- EMD,    Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3
- vitro+vivo, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
STAT3↓, Akt↓, cSrc↓, JAK1↓, JAK2↓, SHP1↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCP↓, Casp3↑, cl‑PARP↑, ChemoSen↑, XIAP↓,
5223- EMD,    Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways
- in-vitro, CRC, DLD1 - in-vitro, Nor, CCD841
tumCV↓, Apoptosis↑, selectivity↑, Casp↑, Bcl-2↓, MMP↓, TumCD↑, MAPK↓, JNK↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, Diff↓, P53↑, PARP↓,
1327- EMD,    Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway
- in-vitro, Lung, A549
Cyt‑c↑, Casp2↑, Casp3↑, Casp9↑, ERK↓, Akt↓, ROS↑, MMP↓, Bcl-2↓, BAX↑,
1322- EMD,    The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers
- Review, Var, NA
Apoptosis↑, TumCP↓, ROS↑, TumAuto↑, EMT↓, TGF-β↓, DNAdam↑, ER Stress↑, TumCCA↑, ATP↓, NF-kB↓, CYP1A1↑, STAC2↓, JAK↓, PI3K↓, Akt↓, MAPK↓, FASN↓, HER2/EBBR2↓, ChemoSen↑, eff↑, ChemoSen↑, angioG↓, VEGF↓, MMP2↓, eNOS↓, FOXD3↑, MMP9↓, TIMP1↑,
1324- EMD,    Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin
- Review, Var, NA
*toxicity↑, *BioAv↓, Akt↓, ERK↓, ROS↑, MMP↓, Bcl-2↓, BAX↑, TumCCA↑,
1325- EMD,  PacT,    Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo
- vitro+vivo, Lung, A549
TumCP↓, Apoptosis↑, BAX↑, Casp3↑, Bcl-2↓, p‑Akt↓, p‑ERK↓, ChemoSideEff∅, ChemoSen↑,
1320- EMD,  SRF,    Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism
- vitro+vivo, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7 - vitro+vivo, Hepat, SK-HEP-1
SREBF2↓, Akt↓, TumCCA↑, TumCG↓, STAT3↓,
6580- EU,    Eurycomanone Blocks TGF-β1-Induced Epithelial-to-Mesenchymal Transition, Migration, and Invasion Pathways in Human Non-Small Cell Lung Cancer Cells by Targeting Smad and Non-Smad Signaling
- in-vitro, Lung, A549 - in-vitro, Lung, Calu-1
TumCMig↓, MMP2↓, EMT↓, E-cadherin↑, Akt↓, N-cadherin↓, TGF-β↓, Smad1↓,
6583- EU,    Inactivation of AKT/NF-κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, Calu-1
tumCV↓, TumCCA↑, Casp3↑, PARP↑, Bcl-xL↓, survivin↓, Akt↓, NF-kB↓, ChemoSen↑,
6585- EU,    Anti-Tumor Activity of Eurycoma longifolia Root Extracts against K-562 Cell Line: In Vitro and In Vivo Study
- vitro+vivo, AML, K562
Dose↝, TumCG↓, Apoptosis↑, TumCCA↑, DNAdam↑, Akt↓, Bcl-2↓, PCNA↓,
6390- Eug,    Molecular mechanisms of eugenol as an antitumour bioactive compound: A comprehensive review
- Review, Var, NA
TumCCA↑, angioG↓, TumMeta↓, tumCV↓, Casp3↑, Casp6↑, DFF45↑, PARP↑, ROS↑, Cyt‑c↑, MPT↑, *ROS↓, NF-kB↓, COX2↓, 5LO↓, EMT↓, Snail↓, E-cadherin↑, Vim↓, PI3K↓, Akt↓, mTORC2↓, TumAuto↑, FOXO3↓, Apoptosis↑, ChemoSen↑, RadioS↑, DNMT1↓, DNMT3A↓,
6391- Eug,  BCP,  5-FU,    Exploring Mechanism of Actions for Eugenol and Beta-Caryophyllene to Combat Colorectal Cancer Chemotherapy Using Network Pharmacology
- in-vitro, CRC, HCT116
eff↑, ChemoSen↑, HSP90↓, Dose↝, TumAuto↑, Apoptosis↑, PI3K↓, Akt↓, mTOR↓, JNK↓, p38↓, EMT↓,
6381- Eug,    Biological Properties and Prospects for the Application of Eugenol—A Review
- Review, Var, NA
*eff↑, *BioAv↝, *BioAv↝, *BioAv↑, *antiOx↑, *AntiAg↑, *Inflam↓, *AntiBio↑, *MAOA↓, *neuroP↑, *ROS↓, *RNS↓, *eff↑, NF-kB↓, PGE2↓, COX2↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, tumCV↓, PI3K↓, Akt↓, MMPs↓, ChemoSen↑, ALDH↓, *Pain↓, *VGSC↓, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *5LO↓, *chemoPv↑,

Showing Research Papers: 301 to 350 of 663
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 663

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   CYP1A1↑, 1,   GSH↑, 1,   GSH/GSSG↓, 1,   GSR↓, 1,   ox-GSSG↑, 1,   GSTs↑, 1,   HO-1↓, 2,   HO-2↓, 1,   hyperG↓, 1,   MAD↓, 1,   NRF2↓, 1,   NRF2↑, 1,   OXPHOS↝, 1,   ROS↑, 25,   SOD↑, 1,   SOD1↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

KLF5↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 2,   EGF↓, 1,   Insulin↓, 2,   MMP↓, 7,   MMP↑, 1,   MPT↑, 1,   mtDam↑, 2,   OCR↓, 1,   Raf↓, 2,   XIAP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,   ALAT↓, 1,   AMPK↑, 3,   cMyc↓, 2,   ECAR↝, 1,   FABP4↓, 1,   FASN↓, 1,   GlucoseCon↓, 2,   glyC↓, 1,   Glycolysis↓, 6,   HK2↓, 2,   lactateProd↓, 3,   LDH↓, 2,   LDHA↓, 1,   NADPH↓, 1,   p‑PCK1↓, 1,   PDH↝, 1,   PDK1?, 2,   PDK1↓, 1,   PKM2↓, 1,   polyA↓, 1,   PPARγ↑, 1,   SCD1↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,   SREBF2↓, 1,   SREBP2↓, 1,   TS↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 38,   Akt↑, 4,   p‑Akt↓, 9,   Apoptosis↓, 1,   Apoptosis↑, 21,   mt-Apoptosis↑, 1,   ASK1↑, 1,   BAD↓, 1,   BAD↑, 1,   Bak↑, 2,   BAX↑, 13,   Bax:Bcl2↑, 3,   Bcl-2↓, 15,   Bcl-xL↓, 4,   BIM↑, 1,   Casp↑, 4,   Casp2↑, 1,   Casp3↑, 18,   Casp6↑, 1,   Casp8↓, 2,   Casp8↑, 3,   Casp9↑, 6,   Cyt‑c↑, 7,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 1,   Fas↑, 1,   HEY1↓, 1,   HGF/c-Met↓, 1,   Hippo↓, 1,   iNOS↓, 1,   JNK↓, 3,   JWA↑, 1,   MAPK↓, 7,   MAPK↑, 1,   Mcl-1↓, 2,   MDM2↓, 1,   MLKL↑, 1,   Myc↓, 2,   Necroptosis↑, 2,   NOXA↑, 1,   p27↑, 2,   p38↓, 1,   Proteasome↓, 1,   PUMA↑, 1,   p‑RIP1↑, 1,   survivin↓, 5,   Telomerase↓, 1,   TumCD↑, 2,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,   tumCV↓, 9,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↑, 2,   ER Stress↑, 4,   GRP78/BiP↑, 1,   HSP90↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   LC3B↑, 1,   LC3II↑, 2,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 11,   DNMT1↓, 1,   DNMT3A↓, 1,   P53↓, 1,   P53↑, 7,   PARP↓, 1,   PARP↑, 4,   cl‑PARP↑, 6,   PCNA↓, 6,   SIRT6↓, 1,   SIRT6↑, 1,   TP53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 2,   CDK2↑, 1,   CDK4↑, 2,   cycD1/CCND1↓, 6,   cycE/CCNE↓, 1,   P21↑, 6,   p‑RB1↓, 1,   TumCCA↑, 16,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   CDK8↓, 2,   CIP2A↓, 1,   CSCs↓, 4,   Diff↓, 1,   EMT↓, 11,   ERK↓, 6,   p‑ERK↓, 3,   FOXO3↓, 1,   Gli1↓, 2,   p‑GSK‐3β↑, 1,   HH↓, 2,   IGF-1↓, 3,   IGF-1R↑, 1,   IGFBP1↑, 1,   IGFBP7↑, 1,   p‑IGFR↓, 1,   miR-34a↓, 1,   mTOR↓, 5,   mTOR↑, 2,   mTOR⇅, 1,   p‑mTOR↓, 1,   mTORC2↓, 1,   Nanog↓, 1,   NOTCH↓, 4,   NOTCH1↓, 2,   NOTCH3↓, 2,   OCT4↓, 1,   P90RSK↓, 1,   PI3K↓, 20,   PI3K↑, 3,   PTEN↑, 2,   RAS↓, 1,   Shh↓, 2,   SHP1↑, 1,   Smo↓, 1,   STAT↓, 2,   STAT3↓, 11,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   STAT6↓, 1,   TumCG↓, 10,   TumCG↑, 1,   Wnt↓, 1,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg?, 1,   AP-1↓, 1,   Ca+2↝, 1,   E-cadherin↑, 6,   FAK↓, 1,   p‑FAK↓, 1,   GLI2↓, 1,   Ki-67↓, 3,   KLF2↓, 1,   MMP2↓, 10,   MMP9↓, 7,   MMPs↓, 2,   N-cadherin↓, 2,   NEDD9↓, 1,   PAK1↓, 1,   PKA↓, 1,   PKCδ↓, 3,   SDC1↑, 1,   Slug↓, 1,   Smad1↓, 1,   SMAD3↓, 2,   Snail↓, 5,   STAC2↓, 1,   TGF-β↓, 6,   TGF-β↑, 1,   TIMP1↑, 1,   TRIB3↑, 1,   TSC1↑, 1,   TumCI↓, 9,   TumCMig↓, 7,   TumCP↓, 17,   TumCP↑, 1,   TumMeta↓, 6,   TumMeta↑, 1,   Twist↓, 2,   Vim↓, 6,   Zeb1↓, 1,   Zeb1↑, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   ATF4↑, 1,   EGFR↓, 3,   Endoglin↑, 1,   eNOS↓, 1,   Hif1a↓, 6,   miR-210↓, 1,   VEGF↓, 10,   VEGFR2↓, 4,  

Barriers & Transport(tgid=15) ⓘ

CTR1↑, 1,   GLUT1↓, 3,   NHE1↓, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2↓, 7,   IFN-γ↑, 1,   IL12↑, 1,   IL6↓, 2,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 1,   JAK↓, 2,   JAK1↓, 2,   JAK2↓, 1,   NF-kB↓, 15,   NF-kB↑, 1,   PD-1↓, 1,   PD-L1↓, 2,   PGE2↓, 1,   TNF-α↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 5,   CDK6↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   ChemoSen↓, 1,   ChemoSen↑, 16,   Dose↝, 6,   Dose∅, 3,   DrugR↓, 1,   eff↑, 29,   eff↝, 2,   eff∅, 1,   RadioS↑, 6,   selectivity↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 2,   AR↓, 1,   AST↓, 1,   BG↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 3,   GutMicro↑, 1,   HER2/EBBR2↓, 2,   IL6↓, 2,   Ki-67↓, 3,   LDH↓, 2,   Myc↓, 2,   PD-L1↓, 2,   TG/TAG↓, 1,   TP53↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   ChemoSideEff↓, 2,   ChemoSideEff∅, 1,   OS↑, 1,   Risk↓, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 1,  
Total Targets: 306

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   diuretic↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 9,   Catalase↑, 1,   GPx↑, 2,   GSH↓, 1,   GSH↑, 3,   H2O2↓, 1,   HNE↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   MPO↓, 1,   NRF2↓, 1,   NRF2↑, 1,   RNS↓, 1,   ROS↓, 8,   SOD↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   Insulin↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,   ALAT↓, 1,   AMPK↓, 1,   CREB↑, 1,   FGF21↑, 1,   glucose↓, 2,   GlucoseCon↑, 1,   LDL↓, 1,   NAD↓, 1,   PIP3↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   Akt↑, 3,   Apoptosis↓, 1,   BAX↓, 2,   Bcl-2↓, 1,   Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   GADD34↓, 1,   iNOS↓, 2,   MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 2,   LC3II↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FGF↑, 1,   HDAC↓, 1,   PI3K↓, 2,   PTEN↓, 1,   RAS↓, 1,   VGSC↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 1,   Ca+2?, 1,   PKCδ↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 1,   eNOS↑, 1,   Hif1a↓, 1,   NO↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   IFN-γ↓, 1,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL6↓, 2,   Imm↓, 1,   Imm↑, 1,   Inflam?, 1,   Inflam↓, 10,   NF-kB↓, 4,   PGE2↓, 1,   TLR3↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↓, 1,   MAOA↓, 1,   tau↓, 2,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 7,   BioAv↝, 3,   BioEnh↑, 1,   eff↑, 2,   Half-Life∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 2,   cardioP↑, 3,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 4,   memory↑, 2,   neuroP↑, 7,   Pain↓, 1,   toxicity↓, 2,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 106

Scientific Paper Hit Count for: Akt, PKB-Protein kinase B
39 Curcumin
28 Quercetin
24 Thymoquinone
24 Apigenin (mainly Parsley)
21 Baicalein
19 Resveratrol
16 Berberine
16 Chrysin
15 Fisetin
14 Shikonin
13 Alpha-Lipoic-Acid
12 Emodin
11 Magnetic Fields
11 Lycopene
11 Sulforaphane (mainly Broccoli)
10 Ashwagandha(Withaferin A)
10 Eugenol
10 Honokiol
9 Carvacrol
9 EGCG (Epigallocatechin Gallate)
9 Magnolol
8 Silver-NanoParticles
8 Cisplatin
8 Artemisinin
8 Beta-Caryophyllene
8 Rosmarinic acid
8 Capsaicin
8 Deguelin
8 Ellagic acid
8 Piperlongumine
8 Urolithin
7 Propolis -bee glue
7 Cinnamon
7 Citric Acid
7 HydroxyTyrosol
7 Nimbolide
7 Phenethyl isothiocyanate
7 Silymarin (Milk Thistle) silibinin
6 5-fluorouracil
6 Celastrol
6 Dandelion Root
6 Luteolin
5 Allicin (mainly Garlic)
5 Anethole/trans-Anethole
5 Carnosic acid
5 Chlorogenic acid
5 Ursolic acid
5 Naringin
5 Piperine
5 Selenite (Sodium)
4 Coenzyme Q10
4 Astragalus
4 Chemotherapy
4 brusatol
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 Celecoxib
4 Ferulic acid
4 Gambogic Acid
4 Juglone
4 Magnetic Field Rotating
4 Vitamin K2
3 1,8-Cineole
3 doxorubicin
3 Gemcitabine (Gemzar)
3 Paclitaxel
3 Astaxanthin
3 Baicalin
3 Betulinic acid
3 Bufalin/Huachansu
3 Brucea javanica
3 Bacopa monnieri
3 Boron
3 Caffeic acid
3 Thymol-Thymus vulgaris
3 Cucurbitacin
3 Radiotherapy/Radiation
3 diet FMD Fasting Mimicking Diet
3 Eurycomanone
3 Gallic acid
3 Garcinol
3 Pterostilbene
3 Sanguinarine
3 Aflavin-3,3′-digallate
2 3-bromopyruvate
2 Auranofin
2 Berbamine
2 Biochanin A
2 Bromelain
2 Sorafenib (brand name Nexavar)
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Centella asiatica / Gotu kola → asiaticoside
2 Hydroxycinnamic-acid
2 CUSP9
2 Diclofenac
2 diet Methionine-Restricted Diet
2 D-limonene
2 Geraniol
2 Ginseng
2 Hydrogen Gas
2 Huperzine A/Huperzia serrata
2 Melatonin
2 Myricetin
2 Oleuropein
2 Plumbagin
2 Parthenolide
2 α-Santalol/Sandalwood oil
1 Camptothecin
1 chemodynamic therapy
1 Acetyl-l-carnitine
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Aloe anthraquinones
1 almonertinib
1 borneol
1 Caffeine
1 Trastuzumab
1 hydroxychloroquine
1 Carnosine
1 Chocolate
1 Cichoric acid / Chicoric acid
1 immunotherapy
1 Vitamin E
1 Crocetin
1 gefitinib, erlotinib
1 Photodynamic Therapy
1 Dichloroacetophenone(2,2-)
1 Docosahexaenoic Acid
1 Dipyridamole
1 Atorvastatin
1 Disulfiram
1 Copper and Cu NanoParticles
1 Fucoidan
1 Ai-Tong-An-Gao-Ji
1 flavonoids
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Grapeseed extract
1 itraconazole
1 Laetrile B17 Amygdalin
1 Licorice
1 MCToil
1 Metformin
1 Neem
1 nelfinavir/Viracept
1 Docetaxel
1 Oleocanthal
1 Proanthocyanidins
1 sericin
1 Psoralidin
1 salinomycin
1 Selenate
1 Selenium NanoParticles
1 Formononetin
1 acetazolamide
1 statins
1 Tomatine
1 Turmerones
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Wogonin
1 Zinc
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:4  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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