Casp3 Cancer Research Results

Casp3, CPP32, Cysteinyl aspartate specific proteinase-3: Click to Expand ⟱
Source:
Type:
Also known as CP32.
Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a common key protein in the apoptosis and pyroptosis pathways, and when activated, the expression level of tumor suppressor gene Gasdermin E (GSDME) determines the mechanism of tumor cell death.
As a key protein of apoptosis, caspase-3 can also cleave GSDME and induce pyroptosis. Loss of caspase activity is an important cause of tumor progression.
Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to shrink tumors. Crucial for apoptotic function are executioner caspases, most notably caspase-3, that proteolyze a variety of proteins, inducing cell death. Paradoxically, overexpression of procaspase-3 (PC-3), the low-activity zymogen precursor to caspase-3, has been reported in a variety of cancer types. Until recently, this counterintuitive overexpression of a pro-apoptotic protein in cancer has been puzzling. Recent studies suggest subapoptotic caspase-3 activity may promote oncogenic transformation, a possible explanation for the enigmatic overexpression of PC-3. Herein, the overexpression of PC-3 in cancer and its mechanistic basis is reviewed; collectively, the data suggest the potential for exploitation of PC-3 overexpression with PC-3 activators as a targeted anticancer strategy.
Caspase 3 is the main effector caspase and has a key role in apoptosis. In many types of cancer, including breast, lung, and colon cancer, caspase-3 expression is reduced or absent.
On the other hand, some studies have shown that high levels of caspase-3 expression can be associated with a better prognosis in certain types of cancer, such as breast cancer. This suggests that caspase-3 may play a role in the elimination of cancer cells, and that therapies aimed at activating caspase-3 may be effective in treating certain types of cancer.
Procaspase-3 is a apoptotic marker protein.
Prognostic significance:
• High Cas3 expression: Associated with good prognosis and increased sensitivity to chemotherapy in breast, gastric, lung, and pancreatic cancers.
• Low Cas3 expression: Linked to poor prognosis and increased risk of recurrence in colorectal, hepatocellular carcinoma, ovarian, and prostate cancers.
Scientific Papers found: Click to Expand⟱
5880- CAR,    In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, PC9
Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP/DDIT3↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,
5907- CAR,    Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2
- in-vitro, Liver, HepG2
TumCG↓, Apoptosis↓, Casp3↓, cl‑PARP↑, Bcl-2↓, p‑ERK↓, p‑p38↑, *Bacteria↓, *AntiAg↑, *Inflam↓, *antiOx↑, *AChE↓, AntiTum↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp↑, DNAdam↑, selectivity↑,
5901- CAR,    Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement
- Review, Stroke, NA
*neuroP↑, *ROS↓, *MDA↓, *4-HNE↓, *SOD↑, *Catalase↑, *GPx↑, *Apoptosis↓, *cl‑Casp3↓, *TRPM7⇅, *BBB↓, *TRPM7↓,
5897- CAR,    Carvacrol Selectively Induces Mitochondria-Related Apoptotic Signaling in Primary Breast Cancer-Associated Fibroblasts
- in-vitro, BC, NA
Bax:Bcl2↑, PPARα↓, NF-kB↓, SIRT1↑, SIRT3↑, MMP3↓, selectivity↑, Bcl-2↓, BAX↑, Casp3↑, Casp6↑, Casp9↑, mt-Apoptosis↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2/PTGS2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, CompStab↝, CompStab↑,
5891- CAR,  SRF,    Carvacrol enhances anti-tumor activity and mitigates cardiotoxicity of sorafenib in thioacetamide-induced hepatocellular carcinoma model through inhibiting TRPM7
- in-vivo, HCC, NA
Synergy↑, OS↑, hepatoP↑, AFP↓, NOTCH↓, cycD1/CCND1↓, Bcl-xL↑, Casp3↑, TRPM7↓, Dose↝,
1287- CAR,    Carvacrol induces apoptosis in human breast cancer cells via Bcl-2/CytC signaling pathway
- in-vitro, BC, HCC1937
TumCP↓, TumCCA↑, Apoptosis↑, BAX↑, Cyt‑c↑, Casp3↑, Bcl-2↓,
5919- Cats,  Cisplatin,    Uncaria tomentosa Leaves Decoction Modulates Differently ROS Production in Cancer and Normal Cells, and Effects Cisplatin Cytotoxicity
- in-vitro, Liver, HepG2
ROS↑, GSH↓, Apoptosis↑, Casp3↑, Casp7↑, NF-kB↓, selectivity↑, ChemoSen↑, chemoP↑,
5914- Cats,    Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells
- in-vitro, AML, HL-60
*Inflam↓, eff↑, DNAdam↑, Cyt‑c↑, Casp3↑, PARP↑, Fas↑, proCasp8↑, cl‑BID↑, BAX↑, Bcl-xL↑, cl‑Mcl-1↑,
5939- Cela,  Chemo,    Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
- in-vitro, Melanoma, U266 - in-vitro, Melanoma, RPMI-8226
TumCP↓, ChemoSen↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, XIAP↓, Mcl-1↓, NF-kB↓, IL6↓, STAT3↓, Apoptosis↑, TumCCA↑, Casp3↑, HSP90↓, HO-1↑, JAK2↓, Src↓, Akt↑,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2/PTGS2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
5948- Cela,    Recent Trends in anti-tumor mechanisms and molecular targets of celastrol
- Review, Var, NA
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP/DDIT3↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,
6615- Cen,    Asiaticoside suppresses cell proliferation by inhibiting the NF-κB signaling pathway in colorectal cancer
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
Dose↝, TumCP↓, selectivity↑, MMP↓, Apoptosis↑, TumCCA↑, NF-kB↓, CDK4↓, cycD1/CCND1↓, Casp9↑, Casp3↑, Bax:Bcl2↑, TumCG↓, ChemoSen↑, TNF-α↓, IL1β↓, P53↑, P21↑,
6656- Cen,    Recent insights into therapeutic potential and nanostructured carrier systems of Centella asiatica: An evidence-based review
- Review, Var, NA - Review, AD, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *antiOx↑, *cardioP↑, *Inflam↓, *hepatoP↑, *AntiAge↑, *AST↓, *ALAT↓, *LDH↓, *lipid-P↓, Casp3↑, *memory↑, *Wound Healing↑, eff↑,
6651- Cen,    Study of the cytotoxicity of asiaticoside on rats and tumour cells
- vitro+vivo, BC, MCF7
Casp3↑, TNF-α↓, IL1β↓, Apoptosis↑, TumCCA↑, TumVol↓, radioP↑, Inflam↓,
6652- Cen,    AA-PMe, a novel asiatic acid derivative, induces apoptosis and suppresses proliferation, migration, and invasion of gastric cancer cells
- in-vitro, GC, SGC-7901 - in-vitro, GC, HGC27
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Apoptosis↑, Bcl-2↓, BAX↑, cMyc↓, Casp3↑, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, tumCV↓,
6645- Cen,    Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy?—A Review
- Review, Var, NA
TumCD↑, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, P70S6K↓, STAT3↓, N-cadherin↓, β-catenin/ZEB1↓, CLDN1↓, Vim↓, TumAuto↑, *BioAv↓, Casp3↑, ROS↑, MMP15↓, MMP↓, Synergy↑, *toxicity↓,
6017- CGA,    Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment
- Review, Var, NA
AntiCan↑, *chemoP↑, TNF-α↓, COX2/PTGS2↓, IL6↓, eff↑, PD-L1↓, *cognitive↓, *Aβ↓, *TAC↑, *SOD↑, *eff↑, *eff↑, ChemoSen↑, tumCV↓, Apoptosis↑, ERK↓, chemoP↑, *GPx↑, *GSTs↑, *GSH↑, *SOD↑, *Catalase↑, *ROS↓, *lipid-P↓, *MDA↓, *Casp3↓, *HO-1↓, cardioP↑, radioP↑,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *Stroke↓, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
6009- CGA,    Chlorogenic Acid: An In-Depth Review of Its Effectiveness in Cancer Treatment
- Review, Var, NA
TumCCA↑, TumCI↓, TumMeta↓, angioG↓, ROS↑, ChemoSen↑, BioAv↓, Half-Life↓, PI3K↓, Akt↓, mTOR↓, Apoptosis↑, NOTCH↓, Hif1a↓, VEGF↓, Casp3↑, MMP↓, Ferroptosis↑, ATP↓,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP/DDIT3↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2/PTGS2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6012- CGA,    Chlorogenic Acid as a Potential Therapeutic Agent for Cholangiocarcinoma
- in-vitro, CCA, HCC9810
TumCP↓, TumCMig↓, TumCI↓, EMT↓, Apoptosis↑, TumCCA↑, AKR1B10↓, Akt↓, mtDam↑, BAX↑, Casp9↑, Casp3↑, Bcl-2↓,
1298- CGA,    Chlorogenic acid regulates apoptosis and stem cell marker-related gene expression in A549 human lung cancer cells
- in-vitro, Lung, A549
Bcl-2↓, BAX↑, Casp3↑, p38↑, JNK↑, Nanog↓, SOX2↓, OCT4↓,
6654- CGA,    Chlorogenic acid induces 4T1 breast cancer tumor's apoptosis via p53, Bax, Bcl-2, and caspase-3 signaling pathways in BALB/c mice
- in-vivo, BC, 4T1
TumW↓, TumVol↓, TumMeta↓, Bax:Bcl2↑, P53↑, Casp3↑,
6630- CGA,    In Vitro and In Silico Study on the Impact of Chlorogenic Acid in Colorectal Cancer Cells: Proliferation, Apoptosis, and Interaction with β-Catenin and LRP6
- in-vitro, CRC, HT29 - in-vitro, CRC, SW480
tumCV↓, DNAdam↑, mt-ROS↑, MMP↓, Casp3↑, eff↝,
7180- CHA,    Chaetocin: A review of its anticancer potentials and mechanisms
- Review, Var, NA
TumCG↓, TumCP↓, Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumCMig↓, SUV39H↓, TrxR↓, Hif1a↓, HSP90↓, ox-Trx1↑, ROS↑, PI3K↓, Akt↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, DR5↑, CHOP/DDIT3↑, ATF3↑, angioG↓, VEGF↑, LDHA↓, ENO1↓,
7185- CHA,    Chaetocin-induced ROS-mediated apoptosis involves ATM–YAP1 axis and JNK-dependent inhibition of glucose metabolism
- vitro+vivo, GBM, A172 - in-vitro, GBM, T98G - in-vitro, GBM, U87MG
HMTs↓, ROS↑, p‑ATM↑, YAP/TEAD↑, p‑JNK↑, TumPF↓, SUV39H↓, TrxR↓, Casp3↑, Trx1↓, H3↓, lactateProd↓, ATP↓, GlucoseCon↓, TumCG↓, Dose↝,
7173- CHA,    Natural compound chaetocin induced DNA damage and apoptosis through reactive oxygen species-dependent pathways in A549 lung cancer cells and in vitro evaluations
- in-vitro, Lung, A549
TumCG↓, TumCCA↑, ROS↑, DNAdam↑, CD47↓, *toxicity↓, MMP↓, Casp3↑, mtDam↓,
7166- CHA,    Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1
- vitro+vivo, AML, U937
SUV39H↓, Apoptosis↑, ROS↑, TumCCA↑, tumCV↓, Casp3↑, Casp9↑, Fas↑, FasL↑, DR4↑, P21↑, eff↓, eff↑,
7164- CHA,    Chaetocin induces apoptosis in human melanoma cells through the generation of reactive oxygen species and the intrinsic mitochondrial pathway, and exerts its anti-tumor activity in vivo
- vitro+vivo, Melanoma, A375
TumCP↓, Apoptosis↑, ROS↑, eff↓, MMP↓, Cyt‑c↑, BAX↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-2↓, TumCG↓, PCNA↓, tumCV↓, NRF2↑, SOD2↑, Catalase↑, NRF2↓, SOD2↓, Catalase↓, TrxR↓,
7159- CHA,    ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
- vitro+vivo, GC, HGC27 - in-vitro, GC, AGS - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, HEK293
TumCP↓, TumCCA↑, Casp↑, Apoptosis↑, TrxR1↓, ROS↑, eff↓, eff↑, PI3K↓, Akt↓, TumCG↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓, TumVol↓, TumW↓, Weight∅, toxicity↓, Ki-67↓, other↝,
5994- Chit,    Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
- Review, Var, NA
angioG↓, *Imm↑, *antiOx↑, selectivity↑, other↝, toxicity↓, BioAv↑, eff↝, Half-Life↑, MPT↑, MMP9↓, lipid-P↑, EPR↑, NK cell↑, Casp3↑, Casp8↑, TumCCA↑, ROS↑, DDS↑, VEGF↓, TIMP1↑, ChemoSen↑, eff↑,
4478- Chit,    Chitosan promotes ROS-mediated apoptosis and S phase cell cycle arrest in triple-negative breast cancer cells: evidence for intercalative interaction with genomic DNA
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, BC, T47D
TumCP↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, Apoptosis↑, Casp3↑,
6130- CHr,    Anticancer Properties of Chrysin on Colon Cancer Cells, In vitro and In vivo with Modulation of Caspase-3, -9, Bax and Sall4
- vitro+vivo, Colon, CT26
tumCV↓, Apoptosis↑, TumVol↓, BAX↑, SALL4↓, Casp3↑, Casp9↑, ChemoSen↑, GSH↓,
6128- CHr,    Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential
- Review, Nor, NA - Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, AntiCan↑, *neuroP↑, *ROS↓, *BioAv↓, *BioAv↑, *cardioP↑, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *lipid-P↓, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *GSH↑, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *5HT↑, *Casp3↓, *Casp9↓, TumCCA↑, MAPK↓, PI3K↓, Akt↓, TumCP↓, TET1↑, TLR4↓, HER2/EBBR2↓, HK2↓, Glycolysis↓, glucose↓, lactateProd↓, ROS↑, mTOR↓, TumAuto↑, tumCV↓, ER Stress↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, BioAv↑,
6126- CHr,    Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis
- in-vitro, Melanoma, NA
tumCV↓, selectivity↑, MPT↑, Cyt‑c↑, Casp3↑, Casp9↑, Apoptosis↑, mtDam↑, chemoPv↑,
2804- CHr,  Rad,    Gamma-Irradiated Chrysin Improves Anticancer Activity in HT-29 Colon Cancer Cells Through Mitochondria-Related Pathway
- in-vitro, CRC, HT29
RadioS↑, ROS↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑,
2805- CHr,    Chrysin serves as a novel inhibitor of DGKα/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC)
- in-vitro, ESCC, KYSE150 - in-vivo, ESCC, NA
FAK↓, GlucoseCon↓, Casp3↑, Casp7↑, p‑Akt↓, TumCG↓, Weight∅,
2807- CHr,    Evidence-based mechanistic role of chrysin towards protection of cardiac hypertrophy and fibrosis in rats
- in-vivo, Nor, NA
*antiOx↑, Inflam↓, *cardioP↑, *GSH↑, *SOD↑, *Catalase↑, *GAPDH↑, *BAX↓, *Bcl-2↑, *PARP↓, *Cyt‑c↓, *Casp3↓, *NOX4↓, *NRF2↑, *HO-1↑, *HSP70/HSPA5↑,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2/PTGS2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓, *antiAll↑,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, Synergy↑, Synergy↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, Synergy↑,
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2/PTGS2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, Synergy↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
2787- CHr,    Network pharmacology unveils the intricate molecular landscape of Chrysin in breast cancer therapeutics
- Analysis, Var, MCF7
TumCP↓, angioG↓, TumCI↓, TumMeta↓, TP53↑, Akt↓, Casp3↑, tumCV↓, TNF-α↓, BioAv↑, BioAv↑, AKT1↓,
2790- CHr,    Chrysin: Pharmacological and therapeutic properties
- Review, Var, NA
*hepatoP↑, *neuroP↓, *ROS↓, *cardioP↑, *Inflam↓, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, MMP9↓, MMP2↓, TIMP1↑, TIMP2↑, BioAv↑, HK2↓, ROS↑, MMP↓, Casp3↑, ADP:ATP↑, Apoptosis↑, ER Stress↑, UPR↑, GRP78/BiP↝, Synergy↑, Ca+2↑,
1144- CHr,    8-bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK
- in-vitro, HCC, HepG2 - in-vitro, HCC, Bel-7402 - in-vitro, Nor, HL7702
Casp3↑, *ROS∅, ROS↑, JNK↑, *toxicity↓,
1145- CHr,    Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways
- in-vitro, Cerv, HeLa
tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB/CCNB1↓, cycD1/CCND1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1 / PDPK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27/CDKN1B↑, P53↑,
1249- CHr,    Chrysin as an Anti-Cancer Agent Exerts Selective Toxicity by Directly Inhibiting Mitochondrial Complex II and V in CLL B-lymphocytes
- in-vitro, CLL, NA
ROS↑, MMP↓, ADP:ATP↑, Casp3↑, Apoptosis↑,

Showing Research Papers: 301 to 350 of 1195
Prev Page 7 of 24 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1195

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 3,   NA↑, 6,   NA⇅, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 7,   antiOx↑, 16,   antiOx⇅, 1,   ARE↓, 1,   Catalase↓, 17,   Catalase↑, 12,   Ceru↓, 1,   Copper↑, 1,   ENOX2↓, 1,   Fenton↑, 4,   frataxin↑, 1,   GCLM↓, 1,   GPx↓, 8,   GPx↑, 9,   GPx4↓, 11,   GSH↓, 82,   GSH↑, 16,   mt-GSH↓, 1,   GSH/GSSG↓, 9,   GSR↓, 3,   GSR↑, 5,   GSS↑, 1,   GSSG↓, 1,   GSSG↑, 1,   GSTs↓, 4,   GSTs↑, 5,   H2O2↓, 1,   H2O2↑, 15,   i-H2O2↑, 1,   mt-H2O2↑, 1,   HO-1↓, 13,   HO-1↑, 22,   HO-1↝, 1,   HO-2↓, 1,   hyperG↓, 1,   Iron↓, 1,   Iron↑, 5,   Iron↝, 1,   i-Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 11,   lipid-P↑, 22,   lipid-P↝, 1,   MDA↓, 8,   MDA↑, 20,   MPO↓, 4,   NADH↓, 1,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 3,   NQO1↑, 5,   Nrf1↑, 1,   NRF2↓, 29,   NRF2↑, 32,   NRF2⇅, 1,   NRF2↝, 1,   NRF2∅, 1,   p‑NRF2↓, 1,   p‑NRF2↑, 1,   OSI↑, 2,   Prx↓, 1,   Prx4↑, 1,   PrxII↓, 1,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 5,   ROS↓, 48,   ROS↑, 523,   ROS⇅, 14,   ROS↝, 2,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 5,   mt-ROS↑, 17,   RPM↑, 1,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 27,   SOD↑, 14,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 6,   SOD2↑, 8,   TAC↓, 2,   TAC↑, 2,   TBARS↑, 3,   Thiols↓, 3,   Thiols↝, 1,   TKT↓, 1,   TOS↑, 2,   Trx↓, 3,   Trx1↓, 2,   Trx1↑, 1,   ox-Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 12,   TrxR1↓, 7,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 3,   FTH1↓, 2,   IronCh↑, 4,   NCOA4↑, 1,   STEAP3↓, 1,   Tf↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 4,   CDC2↓, 9,   CDC2↑, 1,   CDC25↓, 23,   CDC25↑, 1,   p‑CDC25↑, 1,   compI↓, 3,   compII↓, 1,   compIII↓, 2,   compIV↓, 1,   compV↓, 1,   compV↓, 1,   EGF↓, 8,   EGF↑, 1,   ETC↓, 9,   ETC↝, 1,   HSP60/HSPD1↑, 1,   MCU↓, 1,   MFN2↓, 1,   MFN2↑, 1,   mitResp↓, 6,   mitResp↑, 1,   MKK7↓, 1,   mtDam↓, 1,   mtDam↑, 56,   OCR↓, 11,   OCR↑, 2,   OXPHOS↓, 7,   OXPHOS↑, 2,   OXPHOS↝, 1,   mt-OXPHOS↓, 4,   PDH↓, 3,   PDH↑, 3,   PDH↝, 1,   p‑PDH↓, 1,   PINK1↑, 4,   SDH↓, 4,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 6,   5LO↓, 4,   ACC↑, 5,   p‑ACC↑, 1,   Acetyl-CoA↓, 1,   ACLY↓, 5,   ACSL4↑, 2,   adiP↑, 1,   ALAT↓, 6,   ALAT↑, 1,   ALAT↝, 1,   ALDOA↓, 2,   AMP↑, 2,   AMPK↓, 3,   AMPK↑, 39,   p‑AMPK↑, 3,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 39,   ATP↝, 1,   e-ATP↑, 1,   CAIX/CA9↓, 4,   CAIX/CA9↑, 1,   i-Cer↑, 1,   citrate↓, 1,   CPT1A↓, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 4,   FAO↑, 1,   FASN↓, 8,   FASN↑, 2,   FBI-1↓, 1,   FBPase↑, 2,   FFA/NEFA↓, 1,   GALNT10↓, 1,   GAPDH↓, 2,   GLS↓, 1,   glucoNG↓, 1,   glucoNG↑, 2,   glucose↓, 1,   GlucoseCon↓, 24,   GlutaM↓, 1,   GlutMet↓, 2,   glyC↓, 1,   Glycolysis↓, 55,   GSK‐3β↓, 18,   GSK‐3β↑, 8,   p‑GSK‐3β↓, 9,   p‑GSK‐3β↑, 1,   Histones↑, 1,   HK1↓, 2,   HK2↓, 33,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   IDO1↓, 1,   lactateProd↓, 26,   lactateProd↑, 1,   LDHA↓, 13,   LDL↓, 2,   lipidLev↓, 1,   MCT4↓, 1,   NAD↓, 1,   NAD↝, 1,   NADPH↓, 5,   NADPH↑, 2,   O-Glc↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 10,   PDKs↓, 3,   PFK↓, 4,   PFK1↓, 2,   PFK2?, 1,   PFK2↓, 2,   PFKFB4?, 1,   PFKP↓, 1,   PGK1↓, 1,   PKM2↓, 19,   PKM2∅, 1,   PLA2↓, 1,   PPP↓, 2,   Pyruv↓, 1,   Pyruv↑, 1,   p‑S6↓, 1,   SIRT1↓, 12,   SIRT1↑, 7,   SREBP1/SREBF1↓, 3,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 6,   TCA↑, 2,   TS↓, 2,   TumCM/A↓, 1,   Warburg↓, 9,   β-oxidation↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 27,   APAF1↑, 19,   Apoptosis?, 4,   Apoptosis↓, 11,   Apoptosis↑, 587,   Apoptosis↝, 1,   mt-Apoptosis↑, 7,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 4,   BAD?, 1,   BAD↓, 5,   BAD↑, 32,   p‑BAD↓, 1,   Bak↓, 1,   Bak↑, 23,   BAX?, 1,   BAX↓, 9,   BAX↑, 410,   BAX⇅, 1,   BAX↝, 3,   BAX∅, 1,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 85,   Bcl-2↓, 421,   Bcl-2↑, 13,   Bcl-2↝, 3,   Bcl-2∅, 2,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 84,   Bcl-xL↑, 4,   Bcl-xL↝, 2,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 18,   p‑BID↓, 1,   cl‑BID↑, 4,   BIM↓, 1,   BIM↑, 14,   BNIP3?, 1,   BNIP3↑, 3,   BNIP3↝, 1,   BOK↑, 2,   Casp↓, 1,   Casp↑, 28,   Casp1↓, 2,   Casp1↑, 2,   Casp10↓, 1,   Casp10↑, 3,   Casp12?, 1,   Casp12↑, 11,   Casp12↝, 1,   cl‑Casp12↑, 1,   Casp2↑, 5,   Casp3?, 4,   Casp3↓, 15,   Casp3↑, 833,   Casp3↝, 4,   Casp3∅, 2,   cl‑Casp3↓, 3,   cl‑Casp3↑, 204,   cl‑Casp3⇅, 1,   cl‑Casp3∅, 1,   proCasp3↓, 8,   proCasp3↑, 9,   pro‑Casp3↓, 1,   pro‑Casp3↑, 2,   pro‑Casp3↝, 1,   CASP4↑, 3,   Casp6↓, 1,   Casp6↑, 6,   Casp7?, 1,   Casp7↓, 1,   Casp7↑, 88,   cl‑Casp7↑, 11,   Casp8↓, 3,   Casp8↑, 144,   Casp8↝, 1,   Casp8∅, 3,   cl‑Casp8↑, 27,   proCasp8↓, 2,   proCasp8↑, 4,   pro‑Casp8↑, 1,   Casp9?, 2,   Casp9↓, 4,   Casp9↑, 380,   Casp9↝, 1,   Casp9∅, 1,   cl‑Casp9↓, 2,   cl‑Casp9↑, 64,   proCasp9↓, 4,   proCasp9↑, 5,   pro‑Casp9↑, 1,   CellShr↑, 1,   cFLIP↓, 16,   Cupro↑, 1,   Cyt‑c↓, 5,   Cyt‑c↑, 280,   Cyt‑c↝, 4,   Cyt‑c?, 1,   cl‑Cyt‑c↑, 1,   Diablo↑, 12,   DIDO1/DIO-1↑, 1,   DR5↑, 48,   Endon↑, 2,   FADD↑, 14,   Fap1↓, 2,   Fas↓, 3,   Fas↑, 45,   FasL↑, 28,   Ferroptosis↓, 1,   Ferroptosis↑, 15,   GranB/GZMB↝, 1,   GRP58↓, 1,   GSDME↑, 2,   cl‑GSDME↑, 1,   GSDME-N↑, 2,   HEY1↓, 2,   IAP1↓, 15,   IAP2/BIRC3↓, 6,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 2,   iNOS↓, 26,   iNOS↑, 1,   Mcl-1?, 1,   Mcl-1↓, 61,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 17,   MDM2↑, 2,   p‑MDM2↓, 2,   MLKL↑, 3,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 10,   NAIP↓, 2,   Necroptosis↑, 8,   necrosis↑, 6,   NOXA↑, 7,   p38↓, 7,   p38↑, 45,   p‑p38↓, 5,   p‑p38↑, 11,   Paraptosis↑, 1,   PDCD4↑, 1,   Perforin↝, 1,   PUMA↑, 12,   PUMA↝, 1,   Pyro↑, 9,   RIP3↓, 1,   RIP3↑, 5,   p‑RIP3↑, 3,   survivin↓, 107,   survivin↑, 1,   survivin↝, 2,   TNFR 1↑, 3,   TRAIL↑, 11,   TRAIL⇅, 1,   TRAILR↑, 3,   TumCD↓, 5,   TumCD↑, 48,   TumCD∅, 1,   TUNEL↑, 2,   XIAP↓, 54,   XIAP↑, 1,   YAP/TEAD↓, 4,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 226,   Akt↑, 14,   Akt↝, 1,   p‑Akt↓, 87,   AKT1↓, 5,   Akt2↓, 2,   AMPKα↑, 2,   BRAF↓, 2,   BRAF↝, 1,   CaMKII ↓, 3,   CIP2A↓, 2,   CK2↓, 4,   cMET↓, 4,   p‑cMET↑, 2,   p‑CREB↓, 2,   CREB2↓, 1,   cSrc↓, 6,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 49,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 3,   ERK↓, 78,   ERK↑, 17,   ERK↝, 1,   p‑ERK↓, 30,   p‑ERK↑, 8,   e-ERK↑, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 19,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 3,   Hippo↑, 1,   HRAS↓, 1,   IGF-1R↓, 8,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 9,   IKKα↑, 2,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 1,   IκB↑, 3,   p‑IκB↓, 3,   JAK↓, 4,   JAK1?, 1,   JAK1↓, 11,   JAK1↑, 2,   p‑JAK1↓, 2,   JAK2↓, 21,   p‑JAK2↓, 5,   JNK↓, 9,   JNK↑, 55,   JNK↝, 1,   p‑JNK↓, 4,   p‑JNK↑, 12,   cl‑JNK↑, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 47,   MAPK↑, 27,   MAPK↝, 3,   p‑MAPK↓, 3,   p‑MAPK↑, 3,   MARK4↓, 1,   MEK↓, 11,   p‑MEK↓, 4,   p‑MEK↑, 1,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   Mst1↑, 1,   mTOR↓, 111,   mTOR↑, 5,   mTOR↝, 2,   p‑mTOR↓, 27,   mTORC2↓, 4,   NIK↓, 1,   p70S6↓, 2,   P70S6K↓, 9,   p‑P70S6K↓, 2,   P90RSK↓, 1,   PDE3B↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 151,   PI3K↑, 3,   PI3K↝, 1,   p‑PI3K↓, 21,   PI3K/Akt↓, 5,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 4,   PI3k/Akt/mTOR↝, 1,   PIAS-3↑, 1,   PIK3CA↓, 1,   PKA↓, 3,   p‑PKA↓, 1,   PKCδ↓, 12,   p‑PKCδ↓, 1,   cl‑PKCδ↑, 1,   PP2A↑, 1,   PRAS40↑, 1,   PRKCG↑, 1,   PTEN↓, 4,   PTEN↑, 38,   PTEN↝, 2,   p‑PTEN↓, 2,   Raf↓, 7,   c-Raf↓, 1,   RAS↓, 12,   RAS↑, 1,   Rictor↓, 1,   RIP1↓, 2,   RIP1↑, 3,   RPS6KA1↓, 1,   p‑RSK↓, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,   S6K↓, 1,   p‑S6K↓, 2,   SHP1↓, 1,   SHP1↑, 5,   Sp1/3/4↓, 13,   Src↓, 5,   Src↑, 1,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 2,   STAT3↓, 97,   STAT3↑, 5,   p‑STAT3↓, 27,   p‑STAT3↑, 2,   STAT5↓, 3,   p‑STAT5↓, 1,   STAT6↓, 3,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 2,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   AntiThr↑, 1,   ATF1↓, 1,   ATF2↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 24,   ATF4↝, 1,   ATFs↑, 1,   ChrMod↑, 1,   ChrMod↝, 1,   cJun↓, 7,   cJun↑, 5,   p‑cJun↑, 2,   cMyc↓, 59,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 12,   DNMT1↑, 1,   DNMT3A↓, 4,   DNMTs↓, 9,   EZH2↓, 2,   FOXM1↓, 8,   FOXO↑, 2,   FOXO1↓, 2,   FOXO1↑, 4,   FOXO3↓, 7,   FOXO3↑, 9,   FOXO3↝, 1,   p‑FOXO3↓, 2,   FOXO4↑, 2,   GATA3↑, 1,   H3↓, 5,   H3↑, 2,   ac‑H3↑, 3,   H4↓, 1,   H4↑, 2,   ac‑H4↑, 2,   HATs↓, 7,   HATs↑, 2,   HDAC↓, 33,   HDAC1↓, 7,   HDAC10↑, 1,   HDAC2↓, 5,   HDAC3↓, 4,   HDAC8↓, 3,   HES1↓, 2,   HMTs↓, 2,   HOXB-AS1↓, 1,   KCNQ1OT1↓, 1,   KLF2↓, 1,   KLF5↓, 1,   miR-106b↓, 1,   miR-107↑, 1,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 4,   miR-17↓, 2,   miR-195↑, 1,   miR-200b↑, 1,   miR-21↓, 10,   miR-21↑, 1,   miR-22↑, 1,   miR-221↓, 1,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-25-5p↑, 1,   miR-27a-3p↓, 2,   miR-27a-3p↑, 1,   miR-29b↓, 1,   miR-30a-5p↑, 1,   miR-320a↓, 1,   miR-340↓, 1,   miR-340↑, 1,   miR-34a↓, 2,   miR-34a↑, 5,   miR-34b-5p↑, 1,   miR-384↑, 2,   miR-422a↑, 1,   miR-497↑, 1,   miR-590-3p↑, 1,   Myc↓, 6,   MYCN↓, 1,   n-MYC↓, 1,   NR1D2↓, 1,   OCT4↓, 17,   OCT4↑, 1,   other?, 1,   other↓, 5,   other↑, 10,   other↝, 13,   PhotoS↑, 2,   SALL4↓, 1,   sonoS↑, 2,   SOX2↓, 10,   SOX4↓, 1,   SOX4↑, 2,   SOX9?, 1,   SOX9↓, 1,   SUV39H↓, 3,   TCF-4↓, 2,   TET3↑, 1,   tumCV?, 3,   tumCV↓, 196,   tumCV↑, 1,   tumCV∅, 1,   ZBTB10↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 6,   cl‑ATF6↑, 1,   c-ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 57,   cl‑CHOP/DDIT3↑, 1,   CRT↑, 1,   CUL1↝, 1,   CUL5↝, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 14,   p‑eIF2α↓, 1,   p‑eIF2α↑, 13,   ER Stress↓, 5,   ER Stress↑, 94,   ER Stress↝, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 34,   GRP78/BiP↝, 1,   GRP94↑, 4,   HSF1↓, 1,   HSP27↓, 10,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 10,   HSP70/HSPA5↑, 4,   HSP70/HSPA5⇅, 1,   HSP70/HSPA5↝, 1,   HSP72↓, 1,   HSP90↓, 16,   HSP90↑, 3,   HSPs↓, 1,   IRE1↑, 9,   p‑IRE1↑, 1,   PDI↑, 1,   PERK↑, 17,   p‑PERK↑, 3,   SERPINH1/HSP47↓, 1,   UPR↑, 16,   XBP-1↓, 2,   XBP-1↑, 8,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 4,   ATG5↑, 19,   ATG5↝, 1,   ATG7↑, 5,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 34,   Beclin-1/ATG6↝, 1,   CTSB↓, 2,   CTSD↓, 2,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 9,   LC3A↑, 3,   LC3B↑, 6,   LC3B-II↑, 5,   LC3I↓, 1,   LC3I↑, 2,   LC3II↓, 3,   LC3II↑, 29,   LC3s↓, 1,   LC3s↑, 3,   MitoP↑, 2,   p62↓, 13,   p62↑, 10,   PARK2↑, 4,   RUBCN↓, 1,   SESN2↑, 2,   TumAuto↑, 93,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   APE1/APEX1↓, 1,   ATM↓, 1,   ATM↑, 4,   p‑ATM↑, 3,   ATR↑, 1,   BRCA1↓, 2,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 2,   DFF45↑, 3,   DNA-PK↑, 2,   DNAdam↓, 4,   DNAdam↑, 154,   mt-DNAdam↑, 2,   DNArepair↓, 5,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC3↑, 1,   ERCC4/XPF↓, 1,   FEN1↓, 1,   hTERT/TERT↓, 18,   Ku70/XRCC6↓, 2,   MGMT↓, 2,   NHEJ↓, 1,   p16↑, 6,   P53?, 1,   P53↓, 6,   P53↑, 204,   P53↝, 3,   P53∅, 2,   p‑P53↓, 1,   p‑P53↑, 12,   ac‑P53↑, 1,   p53 Wildtype↓, 2,   PARP↓, 11,   PARP↑, 65,   PARP↝, 2,   p‑PARP↑, 5,   cl‑PARP↓, 4,   cl‑PARP↑, 247,   cl‑PARP↝, 1,   cl‑PARP∅, 2,   proPARP↓, 2,   PARP1↓, 1,   PARP1↑, 9,   cl‑PARP1↑, 6,   PCNA↓, 52,   RAD51↓, 1,   SIRT6↑, 1,   SMG1↑, 1,   Telomerase↓, 18,   TOP1↓, 6,   TOP2↓, 6,   TOP2↑, 1,   TP53↓, 3,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   XRCC1↓, 2,   γH2AX↓, 1,   γH2AX↑, 21,   γH2AX↝, 1,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   CC(CDKs/cyclins)↓, 1,   CDK1↓, 31,   CDK1↑, 4,   p‑CDK1↓, 2,   p‑CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 55,   CDK2↑, 5,   p‑CDK2↓, 1,   CDK4↓, 67,   CDK4↑, 6,   CDK4↝, 1,   p‑CDK4↓, 1,   CDK6↓, 28,   CDK6↑, 5,   CDK8↓, 1,   CDKN2C/p18↑, 1,   CHK1↓, 4,   CHK1↑, 1,   p‑CHK1↓, 1,   p‑CHK1↑, 2,   Chk2↓, 2,   Chk2↑, 1,   p‑Chk2↓, 1,   p‑Chk2↑, 1,   ChrCon↑, 2,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 16,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 50,   CycB/CCNB1↑, 6,   cycD1/CCND1↓, 150,   cycD1/CCND1↑, 6,   cycD1/CCND1↝, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 33,   cycE/CCNE↑, 1,   cycE1↓, 2,   cycF↑, 1,   E2Fs↓, 5,   FBXO5/EMI1↓, 1,   GADD45A↓, 1,   GADD45A↑, 2,   Ki-67↓, 53,   MAD↓, 1,   mitA↑, 6,   p19↑, 2,   P21?, 2,   P21↓, 14,   P21↑, 129,   P21↝, 2,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 51,   pRB↓, 1,   pRB↑, 3,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 7,   Securin↓, 2,   TubPol↓, 1,   TumCCA?, 2,   TumCCA↓, 10,   TumCCA↑, 386,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 2,   ALDH↓, 5,   ALDH1A1↓, 3,   Axin2↑, 1,   BMI1↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 2,   CD133↓, 10,   CD24↓, 2,   CD34↓, 2,   CEBPA↑, 1,   cFos↓, 10,   cFos↑, 1,   cMYB↓, 1,   CSCs?, 1,   CSCs↓, 48,   Diff↓, 1,   Diff↑, 2,   EIF4E↓, 2,   FGF↓, 4,   Gli↓, 3,   Gli1↓, 13,   HH↓, 11,   IGF-1↓, 13,   p‑IGF-1↓, 1,   IGF-2↓, 2,   IGF-2↑, 1,   IGFBP1↑, 2,   IGFBP3↑, 5,   JAG1↓, 1,   Jun↓, 2,   Ki-67↓, 53,   Let-7↓, 1,   Let-7↑, 4,   MCM2↓, 1,   mTORC1↓, 8,   p‑mTORC1↓, 1,   Nanog↓, 14,   Nanog↑, 1,   Nestin↓, 4,   NICD↓, 1,   NOTCH↓, 19,   NOTCH1↓, 17,   NOTCH1↑, 2,   NOTCH2↑, 1,   NOTCH3↓, 5,   OGFr↑, 2,   PCLAF↓, 1,   circ‑PLEKHM3↑, 1,   PTCH1↓, 2,   PTCH2↓, 2,   SCF↓, 2,   Shh↓, 14,   Smo↓, 7,   STAT1↓, 2,   Sufu↑, 1,   TAZ↓, 1,   TumCG?, 2,   TumCG↓, 188,   TumCG↑, 4,   TumCP?, 1,   TumCP↓, 300,   TumCP↑, 5,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt?, 1,   Wnt↓, 49,   Wnt↑, 1,   Wnt/(β-catenin)↓, 7,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 13,   AP-1↑, 1,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 2,   BACH1↓, 1,   Ca+2↓, 9,   Ca+2↑, 60,   Ca+2↝, 8,   i-Ca+2?, 1,   i-Ca+2↑, 6,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal1↑, 2,   cal2↓, 1,   cal2↑, 6,   CCN2/CTGF↓, 1,   Cdc42↓, 2,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 2,   COL3A1↓, 1,   DLC1↑, 2,   E-cadherin↓, 9,   E-cadherin↑, 64,   EM↑, 1,   EMT?, 1,   EMT↓, 89,   EMT↑, 3,   EMT↝, 1,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 23,   p‑FAK↓, 4,   p‑FAK↑, 1,   Fibronectin↓, 5,   GIT1↓, 1,   GLI2↓, 6,   hnRNPA1↓, 1,   IQGAP3↓, 1,   ITGA5↓, 2,   ITGB1↓, 3,   ITGB3↓, 2,   ITGB4↓, 1,   LAMs↓, 2,   LEF1↓, 3,   LIMK2↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 3,   MET↑, 1,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 6,   MMP13↓, 4,   MMP15↓, 1,   MMP16↓, 2,   MMP2↓, 127,   MMP2↝, 1,   proMMP2↓, 1,   MMP3↓, 10,   MMP7↓, 14,   MMP9↓, 146,   MMP9↑, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 45,   MTA1↓, 2,   MUC4↓, 1,   N-cadherin?, 1,   N-cadherin↓, 46,   p44↓, 1,   p‑p44↓, 1,   PAI-1/SERPINE1↑, 1,   PAK1↓, 2,   pax↓, 1,   p‑pax↓, 1,   PCBP1↓, 1,   PDGF↓, 6,   proline↓, 1,   Rac1↓, 3,   RECK↑, 1,   Rho↓, 4,   Rho↑, 1,   ROCK1↓, 3,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 20,   Smad1↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 4,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↓, 1,   p‑SMAD4↓, 2,   Snail?, 1,   Snail↓, 43,   TET1↑, 6,   TGF-β↓, 20,   TGF-β↑, 5,   TGF-β1↓, 1,   THBS1↑, 1,   TIMP1↓, 5,   TIMP1↑, 18,   TIMP2↓, 4,   TIMP2↑, 17,   TIMP3↑, 1,   TPM4↓, 1,   TRIB3↑, 2,   TSC1↑, 1,   TSP-1↑, 3,   TumCA↓, 4,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 124,   TumCI↑, 1,   TumCMig↓, 119,   TumCMig↑, 1,   TumMeta?, 1,   TumMeta↓, 87,   TumMeta↑, 5,   TumPF↓, 4,   Twist↓, 21,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 26,   uPA↝, 1,   uPAR↓, 1,   UroPA↓, 1,   Vim↓, 49,   Vim↑, 1,   Zeb1↓, 15,   Zeb1↑, 1,   ZEB2↓, 3,   α-SMA↓, 1,   α-tubulin↓, 3,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 62,   β-catenin/ZEB1↑, 3,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 117,   angioG↑, 2,   CD31/PECAM-1↓, 12,   EGR1↑, 1,   Endoglin↑, 3,   eNOS↓, 3,   eNOS↑, 1,   HIF-1↓, 4,   Hif1a↓, 90,   Hif1a↑, 2,   NO↓, 5,   NO↑, 4,   NO↝, 1,   VCAM-1↓, 4,   VEGF↓, 151,   VEGF↑, 2,   VEGF↝, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 23,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 6,   BBB∅, 2,   CellMemb↓, 1,   CellMemb↑, 1,   CLDN1↓, 3,   CLDN1↑, 1,   CLDN2↓, 2,   CLDN2↑, 1,   CX43/GJA1↓, 1,   EPR↑, 6,   GLUT1↓, 18,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 2,   IBI↑, 1,   KCNH2/hERG↓, 1,   memfluid↓, 1,   MMP?, 3,   MMP↓, 329,   MMP↑, 4,   MMP↝, 1,   MMP∅, 2,   MPT↑, 14,   NHE1↓, 2,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2↝, 1,   TJ↑, 1,   TRPM7↓, 3,   TRPV1↑, 4,   TRPV1↝, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CCR7↓, 2,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 5,   CD44↓, 17,   CD47↓, 1,   CD8+↑, 3,   cDC2↓, 5,   p‑cDC2↓, 1,   p‑cDC2↑, 1,   COX1?, 1,   COX1↓, 2,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 110,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 3,   CXCR2↓, 1,   CXCR4↓, 16,   CXCR4↑, 1,   DCells↑, 1,   DR4↑, 12,   DR4∅, 1,   DR6↑, 1,   FOXP3↓, 2,   FOXP3↑, 2,   Gal-3↓, 1,   HLA-I/II↑, 1,   HMGB1↓, 5,   HMGB1↑, 1,   ICAM-1↓, 6,   IFN-γ↓, 4,   IFN-γ↑, 4,   Igs↓, 1,   IL1↓, 5,   IL1↑, 2,   IL10↓, 8,   IL10↑, 2,   IL12↓, 2,   IL12↑, 1,   IL17↓, 2,   IL18↓, 1,   IL18↑, 1,   IL1α↓, 1,   IL1β↓, 22,   IL1β↑, 5,   IL2↓, 2,   IL2↑, 6,   IL22↓, 1,   IL23↓, 1,   IL4↓, 3,   IL4↑, 2,   IL5↓, 1,   IL6↓, 66,   IL6↑, 1,   IL6↝, 1,   IL8↓, 13,   Imm↑, 16,   Imm↝, 3,   Inflam↓, 47,   pol-M1↑, 1,   MCP1/CCL2↓, 6,   MCT1↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NAF1↓, 1,   NF-kB↓, 211,   NF-kB↑, 11,   NF-kB↝, 1,   p‑NF-kB↓, 3,   p‑NF-kB↑, 2,   NK cell↑, 7,   NLRP3↓, 3,   NLRP3↑, 2,   NOD1↓, 1,   p50↓, 3,   p65↓, 11,   p‑p65↓, 3,   ac‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 9,   PGE2↓, 26,   PSA↓, 11,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   RANTES?, 1,   SOCS-3↓, 1,   SOCS1↑, 1,   T-Cell↑, 2,   T-Cell↝, 1,   TCF↓, 2,   TCF↑, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR4↓, 11,   TLR4↝, 1,   TNF-α↓, 52,   TNF-α↑, 11,   TNF-α↝, 1,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 4,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   GGT/CD224↑, 1,   IM↓, 1,   pH↓, 1,   pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 1,   PTN↓, 1,   SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   ACE/ACE1↓, 1,   AhR↑, 1,   AR↓, 21,   AR↝, 1,   AR-V7?, 1,   CYP19?, 1,   ER-α36↓, 5,   ER(estro)↓, 1,   GR↑, 1,   PPARα↓, 4,   cl‑PPARα↓, 1,   PPARγ↓, 4,   PPARγ↑, 8,   RANKL↓, 1,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 48,   BioAv↑, 56,   BioAv↝, 11,   BioEnh↑, 6,   ChemoSen?, 2,   ChemoSen↓, 3,   ChemoSen↑, 201,   ChemoSen↝, 1,   CompStab↓, 3,   CompStab↑, 5,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1B1↑, 1,   CYP3A4↓, 2,   DDS↑, 2,   Dose?, 12,   Dose↓, 5,   Dose↑, 11,   Dose⇅, 1,   Dose↝, 92,   Dose∅, 18,   eff↓, 138,   eff↑, 136,   eff↝, 16,   eff∅, 5,   GSTA1↓, 1,   GSTA1↑, 2,   Half-Life↓, 12,   Half-Life↑, 2,   Half-Life↝, 12,   Half-Life∅, 1,   MDR1↓, 6,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 19,   P450↓, 5,   RadioS?, 1,   RadioS↑, 60,   selectivity?, 2,   selectivity↓, 1,   selectivity↑, 166,   selectivity∅, 1,   Synergy?, 1,   Synergy↑, 140,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 4,   ALAT↓, 6,   ALAT↑, 1,   ALAT↝, 1,   ALP↓, 4,   ALP↝, 1,   AR↓, 21,   AR↝, 1,   ascitic↓, 1,   AST↓, 5,   AST↑, 1,   AST↝, 1,   BG↓, 1,   BloodF↓, 1,   BRAF↓, 2,   BRAF↝, 1,   BRCA1↓, 2,   p‑BRCA1↑, 1,   CA19-9↓, 1,   CEA↓, 3,   CRP↓, 3,   E6↓, 5,   E7↓, 4,   EGFR↓, 49,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 3,   EZH2↓, 2,   Ferritin↓, 3,   FOXM1↓, 8,   HER2/EBBR2↓, 19,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 18,   IL6↓, 66,   IL6↑, 1,   IL6↝, 1,   LDH?, 1,   LDH↓, 22,   LDH↑, 11,   LDH↝, 2,   i-LDH↓, 1,   Myc↓, 6,   NSE↓, 1,   PD-L1↓, 9,   PSA↓, 11,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   TG/TAG↓, 1,   TP53↓, 3,   TP53↑, 3,   TRIB3↑, 2,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 76,   AntiCan∅, 1,   antiCG↓, 1,   antiD↑, 1,   antiNeop↑, 4,   AntiTum↓, 1,   AntiTum↑, 37,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 4,   cardioP↑, 10,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 37,   chemoPv↑, 31,   ChemoSideEff↓, 11,   ChemoSideEff∅, 1,   cognitive↑, 1,   hepatoP↓, 1,   hepatoP↑, 11,   memory↑, 2,   neuroP↑, 11,   NP/CIPN↓, 1,   OS↑, 20,   OS⇅, 1,   Pain↓, 4,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 3,   QoL↑, 7,   QoL∅, 1,   radioP↑, 9,   Remission↑, 1,   RenoP↑, 13,   Risk↓, 20,   Sleep↑, 1,   Strength↑, 4,   TGFβR1↓, 1,   toxicity?, 1,   toxicity↓, 23,   toxicity↑, 8,   toxicity↝, 10,   toxicity∅, 2,   TumNum↓, 3,   TumVol↓, 58,   TumVol↑, 2,   TumW↓, 27,   Weight↓, 1,   Weight↑, 4,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 1,   AntiP↑, 1,   Bacteria↓, 4,   Bacteria↑, 1,   GutMicro↑, 4,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 3,   Ingr↝, 9,  
Total Targets: 1449

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx?, 1,   antiOx↓, 7,   antiOx↑, 133,   ARE↑, 2,   Bil↓, 1,   Catalase↓, 1,   Catalase↑, 70,   Copper↓, 1,   Fenton↓, 3,   GCLC↝, 1,   GCLM↝, 1,   GPx↑, 54,   GPx1↑, 1,   GPx4↑, 2,   GSH↓, 2,   GSH↑, 78,   GSH/GSSG↑, 1,   GSR↓, 2,   GSR↑, 10,   GSTs↓, 3,   GSTs↑, 19,   H2O2↓, 6,   HDL↑, 4,   HO-1↓, 4,   HO-1↑, 35,   hyperG↝, 1,   Iron↓, 3,   Keap1↓, 3,   Keap1↑, 2,   Keap1↝, 2,   lipid-P↓, 50,   MDA?, 1,   MDA↓, 57,   MDA↑, 4,   MPO↓, 10,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 2,   NQO1↑, 5,   NQO1↝, 1,   NRF2↓, 2,   NRF2↑, 70,   Prx↑, 2,   RNS↓, 6,   ROS?, 1,   ROS↓, 180,   ROS↑, 9,   ROS⇅, 1,   ROS∅, 5,   mt-ROS?, 1,   SOD?, 1,   SOD↓, 3,   SOD↑, 91,   SOD1↑, 4,   SOD2↑, 3,   TAC↑, 9,   TBARS↓, 4,   Thiols↑, 1,   Trx↑, 2,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FPN↑, 1,   IronCh↑, 3,   IronCh↝, 1,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 2,   FIS1↓, 1,   Insulin↑, 3,   MFN2↑, 2,   mitResp↑, 1,   mtDam↓, 5,   PGC-1α↓, 1,   PGC-1α↑, 4,   PGC-1α↝, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 3,   adiP↑, 1,   ALAT↓, 23,   AMPK↓, 1,   AMPK↑, 15,   ATP↓, 3,   ATP↑, 11,   cAMP↑, 2,   DGAT1↓, 1,   FASN↓, 1,   FFA/NEFA↓, 1,   GAPDH↑, 1,   glucose↓, 6,   glucose↝, 4,   GlucoseCon↑, 1,   GlutMet↑, 1,   GSK‐3β↓, 10,   GSK‐3β↑, 3,   p‑GSK‐3β↑, 1,   H2S↑, 2,   HMG-CoA↓, 2,   LDHA↑, 1,   LDL↓, 7,   lipidLev↓, 3,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 4,   NADPH↑, 3,   NH3↓, 1,   PLA2↓, 2,   SIRT1↑, 11,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 3,   APAF1↓, 2,   Apoptosis↓, 46,   Apoptosis∅, 1,   ASC↓, 1,   BAD↓, 3,   BAX↓, 47,   BAX↑, 4,   Bax:Bcl2↓, 8,   Bax:Bcl2↑, 3,   Bcl-2↓, 9,   Bcl-2↑, 31,   Bcl-xL↓, 1,   Bcl-xL↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp12↓, 3,   Casp3?, 1,   Casp3↓, 104,   Casp3↑, 10,   Casp3∅, 2,   cl‑Casp3↓, 20,   cl‑Casp3↑, 1,   proCasp3↓, 2,   proCasp3↑, 1,   Casp7↓, 1,   Casp8↓, 5,   Casp8↑, 1,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 27,   Casp9↑, 4,   Casp9∅, 1,   cl‑Casp9↓, 3,   cl‑Casp9↑, 1,   Cyt‑c↓, 17,   Cyt‑c↑, 1,   Cyt‑c∅, 2,   Fas↓, 2,   Fas↑, 2,   FasL↓, 1,   Ferroptosis↓, 3,   GSDMD↓, 1,   iNOS↓, 26,   iNOS↑, 3,   MLKL↓, 1,   necrosis↓, 1,   p38↓, 3,   p38↑, 1,   p‑p38↓, 2,   Pyro↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 8,   Akt↑, 10,   p‑Akt↓, 4,   p‑Akt↑, 9,   Akt2↓, 1,   CaMKII ↓, 1,   CREB↑, 4,   p‑CREB↑, 3,   EGFR↓, 1,   ERK↓, 6,   ERK↑, 5,   p‑ERK↓, 1,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 2,   IKKα↑, 1,   IκB?, 1,   IκB↑, 1,   JAK↓, 2,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 6,   JNK↑, 3,   p‑JNK↓, 2,   MAPK↓, 19,   MAPK↑, 3,   Mst1↓, 1,   mTOR↓, 3,   mTOR↑, 4,   p‑mTOR↓, 4,   p‑mTOR↑, 2,   p‑p70S6↓, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 8,   PI3K↑, 8,   PKCδ?, 1,   PKCδ↓, 1,   PKCδ↑, 1,   PTEN↓, 2,   RAS↓, 1,   RIP1↓, 2,   STAT↓, 1,   STAT3↓, 2,   STAT3↑, 4,   p‑STAT3↑, 1,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   ATF4↓, 1,   cJun↓, 2,   p‑cJun↓, 2,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO3↑, 1,   HDAC↓, 3,   HDAC2↓, 1,   HDAC3↓, 1,   HOTAIR↑, 1,   other↓, 3,   other↑, 6,   other↝, 12,   RUNX2↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 7,   CHOP/DDIT3↑, 1,   ER Stress↓, 8,   GRP78/BiP↓, 7,   GRP78/BiP↑, 2,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↑, 5,   HSP90↓, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↓, 3,   PERK↓, 2,   UPR↓, 3,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 3,   LC3II↓, 1,   LC3II↑, 4,   MitoP↑, 1,   p62↓, 1,   p62↑, 4,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 9,   p16↓, 1,   P53↓, 7,   P53↑, 2,   PARP↓, 2,   PARP∅, 1,   p‑PARP↓, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 2,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 2,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 4,   P21↑, 2,   RB1↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↓, 1,   Diff↑, 2,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 1,   Ki-67↓, 1,   neuroG↑, 3,   TumCG↓, 1,   TumCP↓, 4,  

Migration(tgid=13) ⓘ

AntiAg↑, 9,   AP-1↓, 3,   mt-ATPase↑, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 7,   Ca+2↑, 1,   Ca+2↝, 3,   cal2↓, 1,   Cartilage↑, 1,   COL1↓, 2,   COL1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 2,   MMP2↑, 1,   MMP3↓, 3,   MMP7↓, 1,   MMP9↓, 5,   MUC1↑, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 6,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 1,   Vim↓, 1,   Zeb1↓, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 2,   eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 4,   Hif1a↑, 1,   NO?, 1,   NO↓, 21,   NO↑, 5,   VCAM-1↓, 4,   VEGF↓, 3,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 2,   BBB↑, 19,   BBB↝, 1,   BBB∅, 2,   CLDN1↓, 1,   CLDN5↓, 1,   GastroP↑, 6,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 6,   MMP↑, 23,   MMP∅, 1,   MUC5AC↓, 1,   OCLN↓, 2,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 3,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPM7⇅, 1,   TRPV1↑, 1,   ZO-1↓, 4,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 3,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 5,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 40,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 9,   IL10↑, 8,   IL12↓, 2,   IL13↑, 1,   IL17↓, 2,   IL18↓, 3,   IL1β↓, 51,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 1,   IL33↓, 1,   IL4↓, 2,   IL4↑, 1,   IL5↓, 1,   IL6↓, 59,   IL6↑, 1,   IL8↓, 7,   Imm↓, 1,   Imm↑, 8,   Imm⇅, 1,   INF-γ↓, 2,   Inflam↓, 161,   Inflam↑, 2,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   MyD88↓, 2,   NeuroI↓, 5,   NF-kB↓, 65,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 10,   p65↓, 2,   PAF↑, 1,   PGE2↓, 20,   PGE2↑, 3,   RAGE↓, 2,   RANTES↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 9,   TNF-α↓, 85,   TNF-α↑, 2,   Treg lymp↝, 1,   TRIF↓, 2,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 5,   Ach↑, 6,   AChE↓, 25,   BChE↓, 6,   BDNF↓, 2,   BDNF↑, 24,   BDNF⇅, 1,   BDNF∅, 1,   ChAT↑, 4,   DA↑, 1,   GABA↑, 1,   MAOA↓, 2,   MAOB↓, 1,   NGF↑, 4,   PSD95↑, 5,   SNAP25↑, 2,   TPH1↓, 1,   TrkB↑, 3,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 2,   Aβ↓, 27,   Aβ42↓, 6,   BACE/β-secretase↓, 9,   IDE↑, 1,   tau↓, 7,   p‑tau↓, 7,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE/ACE1↑, 1,   ACE2↓, 1,   BNP↓, 1,   CYP19↓, 1,   Estro↓, 1,   FGF21↑, 1,   GR↑, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 9,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 48,   BioAv↑, 47,   BioAv⇅, 1,   BioAv↝, 22,   BioAv∅, 1,   BioEnh↑, 2,   ChemoSen↑, 2,   CompStab↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 22,   Dose∅, 2,   eff↓, 5,   eff↑, 21,   eff↝, 1,   GSTA1↑, 2,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 14,   Half-Life∅, 3,   MRP↓, 1,   P-gp/ABCB1↓, 2,   P450↓, 3,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 12,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 23,   ALB↝, 1,   ALP↓, 6,   anemia↓, 1,   AST↓, 24,   BG↓, 1,   Bil↓, 1,   BloodF↑, 2,   BMD↑, 2,   BP↓, 5,   BUN?, 1,   BUN↓, 4,   CEA↓, 1,   colonLen↑, 1,   creat↓, 9,   CRP↓, 7,   EGFR↓, 1,   Ferritin↓, 1,   HemoG↑, 1,   hs-CRP↓, 1,   IL6↓, 59,   IL6↑, 1,   IRes↝, 1,   LDH↓, 12,   NOS2↓, 1,   RAGE↓, 2,   RBC↑, 1,   SpO2↑, 1,   TG/TAG↓, 2,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 7,   antiAll↑, 22,   AntiArt↑, 12,   AntiCan↑, 26,   antiCG↑, 3,   antiD↓, 1,   AntiDiabetic↑, 35,   antiNeop↑, 1,   antiPs↑, 3,   AntiTum↓, 2,   AntiTum↑, 7,   cardioP?, 1,   cardioP↑, 55,   chemoP↑, 12,   chemoPv↑, 6,   cognitive↓, 1,   cognitive↑, 36,   diuretic↑, 3,   GFR↑, 1,   hepatoP↓, 1,   hepatoP↑, 53,   Learn↑, 4,   memory↑, 34,   Mood↑, 1,   motorD↑, 7,   Mucositis↓, 2,   neuroP?, 1,   neuroP↓, 2,   neuroP↑, 100,   Obesity↓, 12,   OS↑, 3,   Pain↓, 4,   radioP↑, 8,   RenoP↓, 1,   RenoP↑, 19,   Risk↓, 1,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 14,   toxicity?, 1,   toxicity↓, 60,   toxicity↑, 4,   toxicity↝, 8,   toxicity∅, 11,   Weight↑, 1,   Weight∅, 1,   Wound Healing↑, 7,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 15,   AntiFungal↓, 1,   AntiFungal↑, 5,   AntiP↓, 1,   AntiP↑, 4,   AntiViral↑, 15,   Bacteria↓, 32,   Diar↓, 3,   GutMicro↑, 17,   Inf↓, 1,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr↑, 1,   Ingr↝, 6,   Phen↑, 1,   QC↑, 1,  
Total Targets: 616

Scientific Paper Hit Count for: Casp3, CPP32, Cysteinyl aspartate specific proteinase-3
38 Silver-NanoParticles
35 Quercetin
32 Curcumin
29 Thymoquinone
26 Apigenin (mainly Parsley)
23 Sulforaphane (mainly Broccoli)
22 Luteolin
21 Baicalein
21 Berberine
18 EGCG (Epigallocatechin Gallate)
18 Emodin
18 Fisetin
17 Shikonin
16 Cisplatin
16 Propolis -bee glue
16 Chrysin
16 Honokiol
14 Artemisinin
14 Magnetic Fields
14 Allicin (mainly Garlic)
14 Capsaicin
14 Licochalcone A
14 Magnolol
13 Ashwagandha(Withaferin A)
13 Radiotherapy/Radiation
13 Kaempferol
12 Betulinic acid
12 Benzyl isothiocyanate
12 Boron
12 Silymarin (Milk Thistle) silibinin
11 doxorubicin
11 Eugenol
11 Gambogic Acid
11 Hyperoside
11 Morin
10 Chlorogenic acid
10 Ginkgetin
10 Graviola
10 isoorientin
10 Juglone
10 Lycopene
10 Matrine
10 Resveratrol
9 Alpha-Lipoic-Acid
9 Carvacrol
9 Phenylbutyrate
8 5-fluorouracil
8 D-limonene
8 Phenethyl isothiocyanate
8 Citric Acid
8 Dandelion Root
8 Formononetin
8 Garcinol
8 Ivermectin
7 Allyl isothiocyanate
7 Melatonin
7 Gallic acid
7 Isobavachalcone
7 Vitexin
7 L-Theanine
7 mebendazole
7 Piperlongumine
7 Rosmarinic acid
6 Beta-Caryophyllene
6 Bufalin/Huachansu
6 chaetocin
6 chitosan
6 Ferulic acid
6 phytic acid, Inositol hexakisphosphate
6 Isoliquiritigenin
6 Licorice
6 Nimbolide
6 Selenite (Sodium)
6 Vitamin K2
5 Boswellia (frankincense)
5 α-Bisabolol / Chamomile oil
5 Caffeic acid
5 Chemotherapy
5 Centella asiatica / Gotu kola → asiaticoside
5 Crocetin
5 Ursolic acid
5 Dichloroacetate
5 salinomycin
5 Ellagic acid
5 Paclitaxel/Taxol
5 Evodiamine
5 Isorhamnetin
5 isoquercitrin
5 lambertianic acid
5 Linalool
5 Magnetic Field Rotating
5 Mangiferin
5 Mushroom Lion’s Mane, Hericium erinaceus
5 Plumbagin
5 Aflavin-3,3′-digallate
4 3-bromopyruvate
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Anethole/trans-Anethole
4 Astaxanthin
4 Photodynamic Therapy
4 Bromelain
4 borneol
4 Carvone
4 Cucurbitacin
4 Geraniol
4 Isovitexin
4 Lemongrass Extract/Citral
4 Lutein
4 methylseleninic acid
4 Moringa oleifera
4 Naringin
4 Marjoram (Origanum majorana)
4 Propyl gallate
4 Piperine
4 VitK3,menadione
4 Urolithin
3 Açaí, Euterpe oleracea
3 Auranofin
3 Metformin
3 Berbamine
3 Biochanin A
3 Brucea javanica
3 Carnosic acid
3 Thymol-Thymus vulgaris
3 Celastrol
3 Cynaropicrin
3 Deguelin
3 Date Fruit Extract
3 Docetaxel
3 Echinacea
3 Fenbendazole
3 Fucoidan
3 Ginkgo biloba
3 Ginkgolide B
3 Gossypol/AT-101
3 Hydrogen Gas
3 Hydroxycinnamic-acid
3 Hibiscus sabdariffa
3 Helleborus niger extracts – Christmas Rose
3 Rutin
3 itraconazole
3 Laetrile B17 Amygdalin
3 Methylsulfonylmethane
3 Patchouli Oil (Pogostemon cablin)
3 Phycocyanin
3 Psoralidin
3 Pterostilbene
3 α-Santalol/Sandalwood oil
3 Vitamin C (Ascorbic Acid)
2 1,8-Cineole
2 Coenzyme Q10
2 Astragalus
2 SonoDynamic Therapy UltraSound
2 entinostat
2 Gemcitabine (Gemzar)
2 tamoxifen
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Andrographis
2 Fennel Oil/Foeniculum vulgare
2 Aloe anthraquinones
2 brusatol
2 Bullatacin
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Cat’s Claw
2 Cichoric acid / Chicoric acid
2 methotrexate
2 Cinnamon
2 Citicoline, CDP-Choline
2 Copper and Cu NanoParticles
2 Oxaliplatin
2 Diclofenac
2 diet FMD Fasting Mimicking Diet
2 Ginkgo biloba-EGb 761
2 Electrical Pulses
2 Eurycomanone
2 Flaxseed/Linseed
2 carboplatin
2 Ginkgolic acids
2 Ginger/6-Shogaol/Gingerol
2 HydroxyCitric Acid
2 HydroxyTyrosol
2 Huperzine A/Huperzia serrata
2 Inositol
2 low dose naltrexone
2 Lactoferrin/Talactoferrin
2 Methyl Jasmonate
2 Magnesium
2 Mistletoe/Viscum album Extracts
2 Mushroom Chaga, Inonotus obliquus
2 Oleuropein
2 Parthenolide
2 Selenium
2 Selenium NanoParticles
2 Vitamin D3
2 Zyflamend
1 5-Aminolevulinic acid
1 Camptothecin
1 Resiquimod
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Angelica archangelica / Garden Angelica
1 2-DeoxyGlucose
1 Ascorbyl Palmitate
1 Trastuzumab
1 almonertinib
1 epirubicin
1 temozolomide
1 Bacopa monnieri
1 Beetroot
1 Black turtle bean
1 Butyrate
1 Mung Bean Sprouts
1 Sorafenib (brand name Nexavar)
1 immunotherapy
1 Polyphenols
1 CUSP9
1 Chlorella (Chlorella vulgaris)
1 Dichloroacetophenone(2,2-)
1 diet Methionine-Restricted Diet
1 Cannabichromene
1 eicosapentaenoic acid
1 ferumoxytol
1 Geldanamycin
1 Radicicol/monorden
1 Bortezomib
1 Flaxseed Oil
1 Galloflavin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 hydrogen sulfide
1 Orlistat
1 Hyperthermia
1 Indole-3-carbinol
1 iodine
1 Inulin Prebiotic
1 Lactobacillus
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lapachol
1 Lasiodin
1 Dordaviprone; Modeyso
1 MCT, metronomic chemo
1 Modified Citrus Pectin
1 Moringin
1 magnetic nanoparticles
1 Iron
1 Lemon Balm/Melissa officinalis
1 Myricetin
1 nelfinavir/Viracept
1 sericin
1 Purple Corn / Purple Maize
1 topotecan
1 isoflavones
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Sanguinarine
1 Scoulerine
1 polyethylene glycol
1 Folic Acid, Vit B9
1 Sesamin
1 Lignans
1 Spirulina(Arthrospira/Limnospira)
1 Osimertinib
1 Adagrasib
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 triptolide
1 Turmerones
1 Vitamin B1/Thiamine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:42  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page