angioG Cancer Research Results

angioG, angiogenesis: Click to Expand ⟱
Source:
Type:
Process through which new blood vessels.
Angiogenesis, the process of new blood vessel formation from pre-existing vessels, plays a crucial role in cancer progression and metastasis. Tumors require a blood supply to grow beyond a certain size and to spread to other parts of the body.
Vascular Endothelial Growth Factor (VEGF): VEGF is one of the most important pro-angiogenic factors. It stimulates endothelial cell proliferation and migration, leading to the formation of new blood vessels. Many tumors overexpress VEGF, which correlates with poor prognosis.
Hypoxia-Inducible Factor (HIF): In response to low oxygen levels (hypoxia), tumors can activate HIF, which in turn promotes the expression of VEGF and other angiogenic factors. This mechanism allows tumors to adapt to their microenvironment and sustain growth.
-Tumour development and progression beyond a size of few millimetres‐cubed crucially depends on the onset of angiogenesis, that is, the ‘angiogenic switch’
Scientific Papers found: Click to Expand⟱
3259- PBG,    Propolis and its therapeutic effects on renal diseases: A review
- Review, Nor, NA
*Inflam↓, *COX2/PTGS2↓, *ROS↓, *NO↓, *NF-kB↓, TumCP↓, angioG↓, VEGF↓, STAT↓, Hif1a↓, RenoP↑, TLR4↓, *MDA↓, *GSH↑, *SOD↑, *Catalase↑, *toxicity∅,
1676- PBG,    Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
- Review, Var, NA
ROS↑, MMP↓, Bcl-2↓, eff↑, tumCV↓, TumCCA↑, angioG↓, PAK1↓, HDAC1↓, HDAC2↓, P53↑, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21?, BAX↑, cl‑Casp3↑, cl‑PARP↑, ChemoSen↑,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, eff↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2/PTGS2↓, eff↑, Bax:Bcl2↑,
1663- PBG,    Propolis and Their Active Constituents for Chronic Diseases
- Review, Var, NA
NF-kB↓, Casp↓, Fas↓, DNAdam↑, Casp3↑, P53↝, MMP↝, ROS↑, mtDam↑, Dose?, angioG↓, TumCP↓, TumCMig↓, BAX↑, selectivity↑, MMP↓, LDH↓, IL6↓, IL1β↓, TNF-α↓,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27/CDKN1B↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
2381- PBG,    Chinese Poplar Propolis Inhibits MDA-MB-231 Cell Proliferation in an Inflammatory Microenvironment by Targeting Enzymes of the Glycolytic Pathway
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCMig↓, TumCI↓, angioG↓, TNF-α↓, IL1β↓, IL6↓, NLRP3↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, ROS↑, MMP↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
4918- PEITC,    Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
- Review, Var, NA
Apoptosis↑, TumCP↓, angioG↓, TumMeta↓, NF-kB↓, Akt↓, MAPK↓, *BioAv↓, ROS↑, lipid-P↑, AIF↑, Cyt‑c↑, DR4↑, DR5↑, TumCCA↑, JAK↓, STAT3↓, MMP2↓, MMP9↓, PKCδ↓, Hif1a↓, JNK↓, Mcl-1↓, COX2/PTGS2↓, MMP↓, Casp3↑, ChemoSen↑, *BioAv↓, Half-Life↓,
4932- PEITC,    Pharmacokinetics and Pharmacodynamics of Phenethyl Isothiocyanate: Implications in Breast Cancer Prevention
- Review, BC, NA
TumCCA↑, ROS↑, GSH↓, ERα/ESR1↓, TumMeta↓, angioG↓,
4939- PEITC,    Phenethyl Isothiocyanate Inhibits Angiogenesis In vitro and Ex vivo
- in-vitro, Pca, PC3 - ex-vivo, Nor, HUVECs
Risk↓, angioG↓, VEGF↓, TumCMig↓, Akt↓, EGF↓, TumCMig↓,
1256- PI,    Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
- in-vitro, adrenal, PHEO - in-vivo, NA, NA
Apoptosis↑, ROS↑, TumCMig↓, TumCI↓, EMT↓, angioG↓, Necroptosis↑, MAPK↑, ERK↑,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *eff↑, *BioAv↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑,
2999- PL,    Piperlongumine alleviates corneal allograft rejection via suppressing angiogenesis and inflammation
- in-vivo, Nor, HUVECs
*Inflam↓, *angioG↓, *Hif1a↓, *VEGF↓, *ICAM-1↓, *VCAM-1↓, *neuroP↑,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
5164- PLB,    Plumbagin inhibits tumour angiogenesis and tumour growth through the Ras signalling pathway following activation of the VEGF receptor-2
- vitro+vivo, CRC, NA - in-vitro, Pca, NA
TumCP↓, TumCMig↓, angioG↓, VEGFR2/KDR/Flk1↓,
4968- PSO,    Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer
- in-vitro, Cerv, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiDiabetic↑, *Bacteria↓, AntiTum↑, CSCs↓, ROS↑, TumAuto↑, Apoptosis↑, ChemoSen↑, RadioS↑, BioAv↓, *cardioP↑, *ROS↓, *LDH↓, TumCP↓, TRAIL⇅, TumCMig↓, EMT↓, NF-kB↓, P53↑, Casp3↑, NOTCH↓, CSCs↓, angioG↓, VEGF↓, Ki-67↓, CD31/PECAM-1↓, TRAILR↑, MMP↓, BioAv↓, BioAv↑,
4694- PTS,    Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions
BioAv↑, AntiCan↑, Casp↑, TumCCA↑, angioG↓, TumMeta↓, MMP9↓, VEGF↓, CSCs↓, CD44↓, cMyc↓, ChemoSen↑, mTOR↓,
4690- PTS,  immuno,    Pterostilbene: Mechanisms of its action as oncostatic agent in cell models and in vivo studies
- Review, Var, NA
eff↑, Half-Life↑, TumCG↓, TumMeta↓, angioG↓, CSCs↓, Apoptosis↑, eff↑, CD44↓, CD24↓,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp/ABCB1↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3363- QC,    The Protective Effect of Quercetin on Endothelial Cells Injured by Hypoxia and Reoxygenation
- in-vitro, Nor, HBMECs
*Apoptosis↓, *angioG↑, *NRF2↑, *Keap1↓, *ATF6↓, *GRP78/BiP↓, *CLDN5↑, *ZO-1↑, *MMP↑, *BBB↑, *ROS↓, *ER Stress↓,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
57- QC,    Quercetin inhibits angiogenesis through thrombospondin-1 upregulation to antagonize human prostate cancer PC-3 cell growth in vitro and in vivo
- vitro+vivo, PC, PC3
TSP-1↑, angioG↓, TumCMig↓, TumCI↓,
50- QC,    Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer
- vitro+vivo, Ovarian, A2780S
Casp3↑, Casp9↑, Mcl-1↓, Bcl-2↓, BAX↑, angioG↓, TumCG↓, Apoptosis↑, p‑p44↓, Akt↓, TumCP↓, eff↑,
92- QC,    Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways
- vitro+vivo, Pca, HUVECs - vitro+vivo, Pca, PC3
VEGFR2/KDR/Flk1↓, HemoG↓, Akt↓, mTOR↓, P70S6K↓, angioG↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
5284- Ramu,    https://pmc.ncbi.nlm.nih.gov/articles/PMC4131847/
- Review, Var, NA
VEGFR2/KDR/Flk1↓, OS↑, angioG↓, toxicity↝, ChemoSen↑, Dose↝,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, eff↑, HK2↓, ROS↑, MMP↓,
3080- RES,    Resveratrol: A miraculous natural compound for diseases treatment
- Review, Var, NA
SIRT1↑, ROCK1↓, AMPK↑, *lipid-P↓, Aβ↓, COX2/PTGS2↓, angioG↓, Hif1a↓, VEGF↓,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2/PTGS2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, eff↑, eff↑, eff↑,
3076- RES,    Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells
- Review, Var, NA
IL6↓, MMPs↓, MMP2↓, MMP9↓, BioAv↓, Half-Life↑, BioAv↑, Dose↝, angioG↓, IL10↓, VEGF↓, NF-kB↓, COX2/PTGS2↓, SIRT1↑, Wnt↓, cMyc↓, STAT3↓, PTEN↑, ROS↑, RadioS↑, Hif1a↓, E-cadherin↓, Vim↓, angioG↓,
3089- RES,    The Role of Resveratrol in Cancer Therapy
- Review, Var, NA
angioG↓, VEGF↓, EGFR↓, FGF↑, TumCMig↓, TumCI↓, TIMP1↑, MMP2↓, MMP9↓, NF-kB↓, Hif1a↓, PI3K↓, Akt↓, MAPK↓, EMT↓, AR↓,
3090- RES,    The Effects of Resveratrol Targeting MicroRNA-4325P/PDGF-B to Regulate Tumor Angiogenesis in Osteosarcoma Microenvironment
- in-vitro, OS, MG63
PDGFR-BB↓, angioG↓,
882- RES,    Resveratrol: A Double-Edged Sword in Health Benefits
- Review, NA, NA
AntiTum↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Bcl-xL↓, P53↑, NAF1↓, NRF2↑, ROS↑, Apoptosis↑, HDAC↓, TumCCA↑, TumAuto↑, angioG↓, iNOS↓,
883- RES,    Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy
HDAC↓, TumCCA↑, Apoptosis↑, angioG↓, ROS↑,
7150- RES,    Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
- Review, Var, NA
AntiTum↑, PI3K↓, Akt↓, *AntiAge↑, *SIRT1↑, *lipid-P↓, *ROS↓, *BioAv↓, *NRF2↑, *HO-1↑, SOD↑, HDAC1↓, PTEN↑, P53↑, TumCCA↑, TumCI↓, TumMeta↓, EMT↓, MMPs↓, MMP9↓, angioG↓, VEGF↓, EGFR↓, FGF21↓, HIF-1↓, *neuroP↑, *cardioP↑, BMPs↑, ROS↑, Vim↓, N-cadherin↓, MMP3↓, MMP13↓, E-cadherin↑, Ki-67↓,
3007- RosA,    Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action
- Review, NA, NA
*ROS↓, *lipid-P↓, *Inflam↓, *neuroP↑, *angioG↓, *eff↑, *AST↓, *ALAT↓, *GSSG↓, *eNOS↓, *iNOS↓, *NO↓, *NF-kB↓, *MMP2↓, *MDA↓, *TNF-α↓, *GSH↑, *SOD↑, *IL6↓, *PGE2↓, *COX2/PTGS2↓, *mTOR↑,
3006- RosA,    Rosmarinic acid attenuates glioblastoma cells and spheroids’ growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229
TumCG↓, EMT↓, SIRT1↓, FOXO1↓, NF-kB↓, angioG↓, ROS↓, PTEN↓, PI3K↓, Akt↓, *Inflam↓, *cardioP↑, *hepatoP↑, *neuroP↑, Warburg↓,
3618- RosA,    Antioxidant and Antimicrobial Properties of Rosemary (Rosmarinus officinalis, L.): A Review
- Review, AD, NA
*hepatoP↑, *antiOx↑, *angioG↓, *other↓, *Inflam↓, *ROS↓, *IronCh↑, *lipid-P↓, *antiOx↑,
3639- Sage,    Pharmacological properties of Salvia officinalis and its components
- Review, AD, NA - Review, Var, NA
AntiCan↑, *Inflam↓, *antiOx↑, *cognitive↑, *memory↑, *LDL↓, TumCG↓, MAPK↓, ROS↓, NF-kB↓, COX2/PTGS2↓, angioG↓, *AST↓, *ALAT?,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27/CDKN1B↑, CHOP/DDIT3↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
6441- SAO,    Sandalwood Album Oil as a Botanical Therapeutic in Dermatology
- Review, PSA, NA
*Inflam↓, *eff↑, *5LO↓, *DPPH↓, *hepatoP↑, *ROS↓, *PGE2↓, *IL1β↓, *IL17↓, *PDE4↓, *tyrosinase↓, *AntiFungal↑, angioG↓, TumCG↓, DNAdam↑, *Snail↑, *Twist↑, *Vim↑, *EMT↓, *toxicity↓,
6442- SAO,    Medicinal properties of alpha-santalol, a naturally occurring constituent of sandalwood oil: review
- Review, RCC, NA
AntiTum↑, Apoptosis↑, TumCCA↑, *Inflam↓, selectivity↑, tumCV↓, Casp8↓, Casp9↓, Casp6↓, Casp3↓, cl‑PARP↑, angioG↓, VEGFR2/KDR/Flk1↓, Akt↑, mTOR↓, TumCG↓, *GSTs↑, *antiOx↑, *ROS↓,
6220- Se,  CUR,  Rad,    Selenium-Curcumin-PEG Nanoparticles Radiosensitization for Intensity-Modulated Radiation Therapy of Lung Tumor Cells: In Vitro Synergistic Combination Therapy
- in-vitro, Lung, A549
RadioS↑, TumCD↑, ROS↑, Imm↑, angioG↓, BioAv↑, TumCP↓, Apoptosis↓, TumMeta↓,
4603- SeNPs,    Therapeutic applications of selenium nanoparticles
- Review, Var, NA
AntiCan↑, Imm↑, *AntiDiabetic↑, *antiOx↑, *Inflam↓, ROS↑, ER Stress↑, DNAdam↑, *toxicity↓, *eff↑, *BioAv↑, selectivity↑, TumCCA↑, Risk↓, *lipid-P↓, *TNF-α↓, *CRP↓, TumMeta↓, angioG↓, selectivity↑, eff↑, *eff↑,
4469- SeNPs,    Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential
- Review, Var, NA
antiOx↑, selectivity↑, eff↑, AntiCan↑, Apoptosis↑, ROS↑, MMP↓, Casp3↑, Casp9↑, AntiTum↑, TumCG↓, TumMeta↓, angioG↓, Cyt‑c↑, DNAdam↑, RadioS↑, BBB↑, *toxicity↓, ChemoSen↑,
3182- SFN,    Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells
- in-vitro, AML, NA
Prx↓, AQPs↓, NOX↓, tumCV↓, AntiCan↑, cardioP↑, neuroP↑, Inflam↓, chemoPv↑, angioG↓, TumMeta↓, selectivity↑, ROS↓,
963- SFN,    Sulforaphane inhibits hypoxia-induced HIF-1α and VEGF expression and migration of human colon cancer cells
- in-vitro, CRC, HCT116 - in-vitro, GC, AGS
Hif1a↓, VEGF↓, angioG↓, Akt∅, ERK∅,
2556- SFN,    The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review
- Review, Var, NA
chemoPv↑, HDAC↓, Hif1a↓, angioG↓, CYP1A1↓, eff↑, BioAv↑,
1469- SFN,    Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vivo, Pca, NA
eff↑, ROS↑, MMP↓, Casp3↑, Casp9↑, DR4↑, DR5↑, BAX↑, Bak↑, BIM↑, NOXA↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, eff↓, TumCG↓, TumCP↓, eff↑, NF-kB↓, PI3K↓, Akt↓, MEK↓, ERK↓, angioG↓, FOXO3↑,

Showing Research Papers: 301 to 350 of 395
Prev Page 7 of 8 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 395

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP2E1↑, 1,   GSH↓, 6,   GSH↑, 1,   HO-1↑, 3,   lipid-P↑, 2,   MDA↓, 1,   MDA↑, 1,   NAF1↓, 1,   NQO1↑, 1,   NRF2↑, 4,   Prx↓, 1,   Prx4↑, 1,   ROS↓, 6,   ROS↑, 24,   SOD↑, 3,   SOD1↑, 1,   SOD2↑, 1,   TrxR↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 2,   EGF↓, 2,   FGFR1↓, 1,   MEK↓, 1,   MMP↓, 14,   MMP↝, 1,   mtDam↑, 2,   OCR↓, 1,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 2,   cMyc↓, 10,   CYP3A4↓, 1,   FGF21↓, 1,   Glycolysis↓, 4,   HK2↓, 5,   LDH↓, 1,   LDH↑, 1,   LDHA↓, 2,   NADPH↑, 1,   PFK↓, 2,   PKM2↓, 2,   SIRT1↓, 2,   SIRT1↑, 3,   SIRT2↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 15,   Akt↑, 1,   Akt∅, 1,   p‑Akt↓, 2,   Apoptosis↓, 1,   Apoptosis↑, 15,   Bak↑, 2,   BAX↓, 1,   BAX↑, 10,   Bax:Bcl2↑, 1,   Bcl-2↓, 8,   Bcl-xL↓, 2,   BIM↑, 2,   Casp↓, 1,   Casp↑, 1,   Casp10↑, 1,   Casp3↓, 2,   Casp3↑, 11,   cl‑Casp3↑, 2,   Casp6↓, 1,   Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 2,   cl‑Casp8↑, 2,   Casp9↓, 1,   Casp9↑, 7,   Cyt‑c↑, 7,   DR4↑, 3,   DR5↑, 4,   Fas↓, 1,   Fas↑, 2,   FasL↑, 1,   iNOS↓, 2,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 4,   MAPK↑, 2,   Mcl-1↓, 3,   MDM2↓, 2,   Myc↓, 1,   Necroptosis↑, 1,   necrosis↑, 1,   NOXA↑, 1,   p27/CDKN1B↑, 2,   p38↑, 1,   PUMA↑, 1,   survivin↓, 5,   Telomerase↓, 1,   TNFR 1↑, 1,   TRAIL⇅, 1,   TRAILR↑, 2,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   Sp1/3/4↓, 5,  

Transcription & Epigenetics(tgid=7) ⓘ

H3↓, 1,   miR-21↑, 1,   other↓, 1,   other↝, 1,   p‑pRB↓, 1,   tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↑, 2,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 1,   PERK↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3B-II↑, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNAdam↑, 7,   P53↑, 9,   P53↝, 1,   p‑P53↑, 1,   PARP↓, 1,   cl‑PARP↑, 6,   PCNA↓, 2,   TP53↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   p‑CDK1↓, 1,   CDK2↓, 2,   CDK2↑, 1,   CDK4↓, 3,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 4,   cycD1/CCND1↓, 6,   cycE/CCNE↓, 1,   P21?, 1,   P21↑, 5,   RB1↓, 1,   p‑RB1↓, 1,   TumCCA↑, 15,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   CD24↓, 1,   CD44↓, 3,   cFos↓, 1,   cMET↓, 1,   CSCs↓, 8,   EMT↓, 10,   ERK↓, 4,   ERK↑, 2,   ERK∅, 1,   p‑ERK↑, 1,   FGF↓, 1,   FGF↑, 1,   FOXO1↓, 1,   FOXO3↓, 2,   FOXO3↑, 1,   p‑FOXO3↓, 1,   Gli1↓, 2,   GSK‐3β↓, 5,   HDAC↓, 4,   HDAC1↓, 2,   HDAC2↓, 1,   IGFBP3↑, 1,   mTOR↓, 8,   Nanog↓, 2,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH1↓, 1,   OCT4↓, 1,   P70S6K↓, 2,   PI3K↓, 6,   PTCH1↓, 1,   PTEN↓, 1,   PTEN↑, 5,   p‑PTEN↓, 1,   RAS↓, 3,   Shh↓, 2,   Smo↓, 1,   SOX2↓, 1,   STAT↓, 1,   STAT1↓, 1,   STAT3↓, 6,   STAT6↓, 1,   TCF↓, 1,   TOP2↓, 3,   TumCG↓, 11,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   i-Ca+2↑, 1,   CD31/PECAM-1↓, 1,   CLDN2↓, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 3,   FAK↓, 1,   p‑FAK↑, 1,   GLI2↓, 1,   ITGB1↓, 1,   ITGB6↓, 1,   Ki-67↓, 3,   KRAS↓, 1,   LEF1↓, 1,   MALAT1↓, 1,   MMP13↓, 1,   MMP2↓, 6,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 10,   MMPs↓, 6,   N-cadherin↓, 2,   p‑p44↓, 1,   PAK1↓, 1,   PDGF↓, 1,   PKCδ↓, 2,   RAGE↓, 1,   ROCK1↓, 1,   Slug↓, 3,   Snail↓, 3,   SOX4↑, 1,   TGF-β↓, 2,   TIMP1↑, 2,   TIMP2↑, 1,   TSP-1↑, 3,   TumCI↓, 9,   TumCMig↓, 12,   TumCP↓, 13,   TumMeta↓, 15,   Twist↓, 2,   uPA↓, 1,   uPAR↓, 2,   Vim↓, 5,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 44,   ATF4↑, 1,   ATF4↝, 1,   EGFR↓, 6,   HIF-1↓, 1,   Hif1a↓, 10,   PDGFR-BB↓, 1,   VEGF↓, 17,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 1,   P-gp/ABCB1↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 10,   CRP↓, 1,   CXCR4↓, 3,   ICAM-1↓, 1,   IFN-γ↓, 1,   IKKα↓, 2,   IL10↓, 2,   IL10↑, 1,   IL1β↓, 3,   IL2↑, 1,   IL6↓, 9,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 3,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 1,   NF-kB↓, 18,   PGE2↓, 1,   TLR4↓, 3,   TNF-α↓, 4,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   NLRP3↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CDK6↓, 2,   ER(estro)↓, 1,   ERα/ESR1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 6,   BioEnh↑, 1,   ChemoSen↑, 13,   ChemoSen⇅, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose?, 2,   Dose↓, 1,   Dose↝, 4,   eff↓, 1,   eff↑, 27,   eff∅, 1,   Half-Life↓, 1,   Half-Life↑, 2,   Half-Life↝, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P450↓, 3,   RadioS↑, 8,   selectivity↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AR↓, 2,   AST↓, 1,   BMPs↑, 1,   CRP↓, 1,   EGFR↓, 6,   ERα/ESR1↓, 1,   HemoG↓, 1,   HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   IL6↓, 9,   Ki-67↓, 3,   KRAS↓, 1,   LDH↓, 1,   LDH↑, 1,   Myc↓, 1,   RAGE↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   AntiTum↑, 5,   cardioP↑, 3,   chemoPv↑, 2,   ChemoSideEff↓, 1,   neuroP↑, 1,   OS↑, 2,   RenoP↑, 1,   Risk↓, 3,   toxicity↓, 1,   toxicity↝, 1,   TumW↓, 1,  
Total Targets: 336

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 9,   Catalase↑, 3,   DPPH↓, 1,   GPx↑, 1,   GPx1↑, 1,   GSH↑, 6,   GSSG↓, 1,   GSTs↑, 2,   HO-1↑, 2,   Keap1↓, 1,   lipid-P↓, 8,   MDA↓, 2,   Nrf1↑, 1,   NRF2↑, 4,   ROS↓, 13,   SOD↑, 4,   SOD1↑, 1,   SOD2↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT?, 1,   ALAT↓, 2,   AMPK↑, 1,   LDH↓, 1,   LDL↓, 1,   PPARγ↑, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   GSK‐3β↓, 2,   mTOR↑, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   MMP2↓, 1,   Snail↑, 1,   Twist↑, 1,   VCAM-1↓, 1,   Vim↑, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   angioG↑, 3,   CLDN5↑, 1,   eNOS↓, 1,   Hif1a↓, 1,   NO↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   CRP↓, 1,   ICAM-1↓, 1,   IL10↓, 1,   IL17↓, 2,   IL1β↓, 2,   IL6↓, 1,   Inflam↓, 12,   MCP1/CCL2↓, 1,   NF-kB↓, 2,   PGE2↓, 2,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 5,   Dose↝, 2,   eff↑, 6,   Half-Life↑, 1,   Half-Life↝, 1,   P450↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 2,   ALP↓, 1,   AST↓, 3,   BP↓, 1,   CRP↓, 1,   IL6↓, 1,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 2,   cardioP↑, 6,   cognitive↑, 2,   hepatoP↑, 5,   memory↑, 3,   motorD↑, 1,   neuroP↑, 8,   Pain↓, 1,   PDE4↓, 1,   toxicity↓, 3,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 1,  
Total Targets: 102

Scientific Paper Hit Count for: angioG, angiogenesis
14 Magnetic Fields
14 Thymoquinone
11 Curcumin
11 Chrysin
9 Fisetin
9 Fucoidan
9 Resveratrol
9 Sulforaphane (mainly Broccoli)
9 Silymarin (Milk Thistle) silibinin
8 Artemisinin
8 Propolis -bee glue
8 Copper and Cu NanoParticles
7 Ashwagandha(Withaferin A)
7 Betulinic acid
7 Cinnamon
7 Eugenol
7 Nimbolide
7 Quercetin
6 Capsaicin
5 Apigenin (mainly Parsley)
5 Berberine
5 chitosan
5 Ellagic acid
5 Radiotherapy/Radiation
5 EGCG (Epigallocatechin Gallate)
5 Formononetin
5 Gambogic Acid
5 Selenite (Sodium)
4 Silver-NanoParticles
4 immunotherapy
4 Beta-Caryophyllene
4 Boswellia (frankincense)
4 Rosmarinic acid
4 Celastrol
4 D-limonene
4 Disulfiram
4 Isoliquiritigenin
4 Luteolin
4 Magnolol
4 Phenethyl isothiocyanate
3 Carvacrol
3 Chlorogenic acid
3 Hydroxycinnamic-acid
3 Coenzyme Q10
3 Crocetin
3 Dichloroacetate
3 Emodin
3 Ferulic acid
3 Gallic acid
3 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
3 Lycopene
3 Piperlongumine
3 tetrathiomolybdate
2 3-bromopyruvate
2 chemodynamic therapy
2 Allicin (mainly Garlic)
2 Alpha-Lipoic-Acid
2 Chemotherapy
2 beta-glucans
2 Baicalein
2 Boron
2 Caffeic acid
2 Carnosic acid
2 chaetocin
2 Carica papaya leaf extract
2 Cucurbitacin
2 Deguelin
2 Diclofenac
2 Dipyridamole
2 Dandelion Root
2 Ginkgo biloba-EGb 761
2 Garcinol
2 Ginkgolide B
2 Helleborus niger extracts – Christmas Rose
2 Honokiol
2 HydroxyTyrosol
2 isoflavones
2 itraconazole
2 Isovitexin
2 metronomic chemo
2 Naringin
2 Piperine
2 Pterostilbene
2 α-Santalol/Sandalwood oil
2 Selenium
2 Selenium NanoParticles
2 Ursolic acid
1 Auranofin
1 Astragalus
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Aspirin
1 Ascorbyl Palmitate
1 Atorvastatin
1 Aloe anthraquinones
1 Biochanin A
1 Bufalin/Huachansu
1 borneol
1 urea
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Sorafenib (brand name Nexavar)
1 Carnosine
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chocolate
1 Metformin
1 Citric Acid
1 Vitamin E
1 diet FMD Fasting Mimicking Diet
1 Zinc
1 Echinacea
1 Electrical Pulses
1 flavonoids
1 olaparib/LYNPARZA
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 Gossypol/AT-101
1 Hydrogen Gas
1 hydrogen sulfide
1 Hibiscus sabdariffa
1 Hops (Humulus lupulus)
1 isoorientin
1 Vitexin
1 Juglone
1 Melatonin
1 Magnetic Field Rotating
1 Mistletoe/Viscum album Extracts
1 Neem
1 Oroxylin-A
1 Oleuropein
1 Oleocanthal
1 Oregano
1 Phenylbutyrate
1 Plumbagin
1 Psoralidin
1 Ramucirumab (CYRAMZA)
1 Salvia officinalis
1 salinomycin
1 Shikonin
1 Theobromine
1 Aflavin-3,3′-digallate
1 Thymol-Thymus vulgaris
1 Urolithin
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:447  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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