angioG Cancer Research Results

angioG, angiogenesis: Click to Expand ⟱
Source:
Type:
Process through which new blood vessels.
Angiogenesis, the process of new blood vessel formation from pre-existing vessels, plays a crucial role in cancer progression and metastasis. Tumors require a blood supply to grow beyond a certain size and to spread to other parts of the body.
Vascular Endothelial Growth Factor (VEGF): VEGF is one of the most important pro-angiogenic factors. It stimulates endothelial cell proliferation and migration, leading to the formation of new blood vessels. Many tumors overexpress VEGF, which correlates with poor prognosis.
Hypoxia-Inducible Factor (HIF): In response to low oxygen levels (hypoxia), tumors can activate HIF, which in turn promotes the expression of VEGF and other angiogenic factors. This mechanism allows tumors to adapt to their microenvironment and sustain growth.
-Tumour development and progression beyond a size of few millimetres‐cubed crucially depends on the onset of angiogenesis, that is, the ‘angiogenic switch’
Scientific Papers found: Click to Expand⟱
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
3267- Lyco,    Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways
- in-vitro, Nor, HUVECs
*VEGF↓, *MMP2↓, *uPA↓, *Rac1↑, *TIMP2↑, *p38↓, *Akt↓, *angioG↓,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, Synergy↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
8418- Lyco,  docx,    A phase I study of docetaxel plus synthetic lycopene in metastatic prostate cancer patients
- Trial, Pca, NA
Dose↝, BioEnh↑, angioG↓, IGF-1↓, ChemoSen↑, BioAv↑, CEC↝,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
8505- MAG,    Role of magnolol in gastrointestinal cancers: Recent trends and future perspectives
- Review, GC, NA
TumCP↓, TumCI↓, TumCMig↓, angioG↓, EMT↓, TumCCA↑, Apoptosis↑, PI3K↝, Akt↝, NF-kB↝, MAPK↝, JNK↝, ERK↝, TGF-β↝, Smad1↝,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27/CDKN1B↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
4515- MAG,    Magnolol as a Potential Anticancer Agent: A Proposed Mechanistic Insight
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↑, angioG↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, NF-kB↓,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, Synergy↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
972- MAG,    Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1α/VEGF signaling pathway in human bladder cancer cells
- vitro+vivo, Bladder, T24/HTB-9
angioG↓, VEGF↓, H2O2↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Akt↓, mTOR↓, P70S6K↓, 4E-BP1↓, TumCG↓, CD31/PECAM-1↓, CA↓,
8536- Matr,    Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway
- vitro+vivo, BC, 4T1 - in-vitro, BC, MCF7
tumCV↓, Apoptosis↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, angioG↓,
8654- MBZ,  SUL,    Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model
- in-vivo, Colon, HT-29 - in-vitro, Colon, SW48
Synergy↑, COX2/PTGS2↓, angioG↓, VEGFR2/KDR/Flk1↓, Ki-67↓, chemoPv↑,
8651- MBZ,  Rad,    Mebendazole and radiation in combination increase survival through anticancer mechanisms in an intracranial rodent model of malignant meningioma
- in-vitro, Var, NA
Dose↝, RadioS↑, cl‑Casp3↑, Apoptosis↑, TumCP↓, angioG↓,
8648- MBZ,    Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature
- Review, Var, NA
angioG↓, MMPs↓, MDR1↓, TubPol↓, RadioS?, ChemoSen?, TumCG↓, TumMeta?, OS↑, BioAv↓, BioAv↑, BBB↑, mitA↑, HH↓, Shh↓, Synergy↑, Gli1↓, PTCH2↓, XIAP↓, cl‑PARP↑, Casp3↑, BRAF↓, MEK↓, SYN1↑, Cyt‑c↑, TumVol↓, VEGFR2/KDR/Flk1↓, VEGF↓, VCAM-1↓, DYRK1B↓, QoL↑, Dose↝,
2487- mCHEMO,    Metronomic Chemotherapy: Possible Clinical Application in Advanced Hepatocellular Carcinoma
- Review, HCC, NA
toxicity↓, toxicity↓, eff↝, angioG↓, CSCs↓, TSP-1↑, Hif1a↓, VEGF↓, eff↑,
2490- mCHEMO,    Durable complete response of hepatocellular carcinoma after metronomic capecitabine
- Case Report, HCC, NA
angioG↓, TumVol↓, Remission↑,
8798- mCHEMO,    Metronomic Chemotherapy in Prostate Cancer
- Review, Pca, NA
TumCP↓, angioG↓, Imm↑, CSCs↑, NA↝,
8782- mCHEMO,  PacT,    Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
- in-vivo, BC, MDA-MB-231 - in-vivo, Pca, PC3
angioG↓, *ChemoSideEff↓, TSP-1↑,
8784- mCHEMO,    Metronomic chemotherapy following the maximum tolerated dose is an effective anti-tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells
- Review, Var, NA
Dose↝, TumCG↓, angioG↓, TSP-1↑, CD133↓, CSCs↓,
8786- mCHEMO,    Metronomic chemotherapy in cancer treatment: new wine in an old bottle
- Review, Var, NA
eff↑, ChemoSideEff↓, angioG↓, *toxicity↓, PFS↑, Hif1a↓, TumCD↑, CSCs↓, EMT↓, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, CD133↓, TumCCA↑, P21↓, DNAdam↑, Imm↑, Synergy↑, Synergy↑,
8787- mCHEMO,    Optimizing cancer therapy: a review of the multifaceted effects of metronomic chemotherapy
- Review, Var, NA
*toxicity↓, angioG↓, Imm↑, DCells↑, T-Cell↑, CSCs?, chemoR↓, QoL↑, RadioS↑, Synergy↑,
8788- mCHEMO,    Metronomic Chemotherapy: A Novel Approach in Cancer Treatment
- Review, Var, NA
angioG↓, Imm↑, toxicity↓, TSP-1↑, Synergy↑,
8789- mCHEMO,    Predictive Biomarkers of Metronomic Chemotherapy Response in Solid Tumors: Chasing an Elusive Signal
- Review, Var, NA
Synergy↑, angioG↓, Apoptosis↑, TSP-1↑, Imm↑, NA↑,
8821- MCP,  Rad,    Modified Citrus Pectin as a Potential Sensitizer for Radiotherapy in Prostate Cancer
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
Gal-3↓, TumCP↓, angioG↓, Apoptosis↑, RadioS?, BAX↓, DNArepair↓, PCNA↓, TumCI↓, TumCCA↑, ROS↑,
8816- MCP,    Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, 4T1
GlucoseCon↓, GLUT1↓, Gal-3↓, ROS↓, NRF2↓, Hif1a↓, angioG↓, pol-M2 MC↓, p‑STAT3↓, TumCG↓, TumW↓,
8716- MeJa,    Methyl jasmonate abolishes the migration, invasion and angiogenesis of gastric cancer cells through down-regulation of matrix metalloproteinase 14
- in-vitro, GC, SGC-7901 - in-vitro, GC, MKN-28
TumCMig↓, TumCI↓, angioG↓, MMP14↓, VEGF↓, Sp1/3/4↓,
8756- MeSA,    THE MAIN CYTOTOXIC EFFECTS OF METHYLSELENINIC ACID ON VARIOUS CANCER CELLS
- Review, Var, NA
ROS↑, GSH↓, RadioS↑, angioG↓, p‑Akt↓, IκB↓, NF-kB↓, ITGB3↓, p‑FOXO3↓, BAX↑, Cyt‑c↑, proCasp3↑, PARP↑, Glycolysis↓, TCA↓, NRF2↑, DNMT1↓, Hif1a↓, ER Stress↑, ChemoSen↑,
8749- MeSA,  etoposide,    Methylseleninic acid enhances the effect of etoposide to inhibit prostate cancer growth in vivo
- in-vivo, Pca, NA
TumCG↓, Apoptosis↑, p‑ERK↓, p‑Akt↓, FABP5/E-FABP↓, angioG↓, VEGF↓, ChemoSen↑,
8763- MeSA,    Methylseleninic Acid Provided at Nutritional Selenium Levels Inhibits Angiogenesis by Down-regulating Integrin β3 Signaling
- vitro+vivo, Nor, HUVECs
eff↑, angioG↓, ITGB3↓, p‑Akt↓, p‑IκB↓, p‑NF-kB↓,
4092- MF,    Mechanisms and therapeutic effectiveness of pulsed electromagnetic field therapy in oncology
- Review, Var, NA
Apoptosis↑, selectivity↑, ROS↑, Catalase↓, TumVol↓, angioG↓, Ca+2↝, eff↝, angioG↓, Imm↝, TNF-α↑, Casp8↑,
3464- MF,    Progressive Study on the Non-thermal Effects of Magnetic Field Therapy in Oncology
- Review, Var, NA
AntiTum↑, TumCG↓, TumCCA↑, Apoptosis↑, TumAuto↑, Diff↑, angioG↓, TumMeta↓, EPR↑, ChemoSen↑, ROS↑, DNAdam↑, P53↑, Akt↓, MAPK↑, Casp9↑, VEGFR2/KDR/Flk1↓, P-gp/ABCB1↓,
3477- MF,    Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosis
- Review, Var, NA
*Ca+2↑, *VEGF↑, *angioG↑, Ca+2↑, ROS↑, Necroptosis↑, TumCCA↑, Apoptosis↑, *ATP↑, *FAK↑, *Wnt↑, *β-catenin/ZEB1↑, *ROS↑, p38↑, MAPK↑, β-catenin/ZEB1↓, CSCs↓, TumCP↓, ROS↑, RadioS↑, Ca+2↑, eff↓, NO↑,
3465- MF,    Magnetic fields and angiogenesis
- Review, Var, NA
angioG↓, *angioG↑, selectivity↑, Ca+2↝, ROS↝,
3466- MF,    The effect of magnetic fields on tumor occurrence and progression: Recent advances
- Review, Var, NA
angioG↓, ROS↝, EGFR↝, TumCG↓,
3467- MF,    Pulsed Magnetic Field Induces Angiogenesis and Improves Cardiac Function of Surgically Induced Infarcted Myocardium in Sprague-Dawley Rats
- in-vivo, Nor, NA
*angioG↑, *cardioP↑,
3536- MF,    Targeting Mesenchymal Stromal Cells/Pericytes (MSCs) With Pulsed Electromagnetic Field (PEMF) Has the Potential to Treat Rheumatoid Arthritis
- Review, Arthritis, NA - Review, Stroke, NA
*Inflam↓, *Diff↑, *toxicity∅, *other↑, *SOX9↑, *COL2A1↑, *NO↓, *PGE2↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *angioG↑, *MSCs↑, *VEGF↑, *TGF-β↑, *angioG↝, *VEGF↓, Ca+2↝,
3478- MF,    One Month of Brief Weekly Magnetic Field Therapy Enhances the Anticancer Potential of Female Human Sera: Randomized Double-Blind Pilot Study
- Trial, BC, NA - in-vitro, BC, MCF7 - in-vitro, Nor, C2C12
TumCP↓, TumCMig↓, TumCI↓, *toxicity∅, TGF-β↓, Twist↓, Slug↓, β-catenin/ZEB1↓, Vim↓, p‑SMAD2↓, p‑SMAD3↓, angioG↓, VEGF↓, selectivity↑, LIF↑,
3482- MF,    Pulsed Electromagnetic Fields Increase Angiogenesis and Improve Cardiac Function After Myocardial Ischemia in Mice
- in-vitro, Nor, NA
*cardioP↑, *VEGF↑, *VEGFR2/KDR/Flk1↑, *Hif1a↑, *FGF↑, *ITGB1↑, *angioG↑,
524- MF,    Inhibition of Angiogenesis Mediated by Extremely Low-Frequency Magnetic Fields (ELF-MFs)
- vitro+vivo, PC, MS-1 - vitro+vivo, PC, HUVECs
other↓, TumCP↓, TumCMig↓, VEGFR2/KDR/Flk1↓, TumVol↓, HSP70/HSPA5↓, HSP90↓, TumCCA↑, angioG↓,
525- MF,    Pulsed electromagnetic fields regulate metabolic reprogramming and mitochondrial fission in endothelial cells for angiogenesis
- in-vitro, Nor, HUVECs
*angioG↑, *GPx1↑, *GPx4↑, *SOD↑, *PFKM↑, *PFKL↑, *PKM2↑, *PFKP↑, *HK2↑, *GLUT1↑, *GLUT4↑, *ROS↓, *MMP↝, *Glycolysis↑, *OXPHOS↓,
509- MF,    Is extremely low frequency pulsed electromagnetic fields applicable to gliomas? A literature review of the underlying mechanisms and application of extremely low frequency pulsed electromagnetic fields
- Review, GBM, NA
Ca+2↑, TumAuto↑, Apoptosis↑, angioG↓, ROS↑,
499- MF,    The Effect of Pulsed Electromagnetic Fields on Angiogenesis
- Review, Var, NA
*angioG↑, *VEGF↑, *VGCC↑,
3497- MFrot,  MF,    The Effect of a Rotating Magnetic Field on the Regenerative Potential of Platelets
- Human, Nor, NA
*PDGFR-BB↑, *TGF-β↑, *IGF-1↑, *FGF↑, *angioG↑, *Inflam↓, *ROS↓,
8669- MLT,    Melatonin in lung cancer: integrating molecular mechanisms, tumor microenvironment regulation, apoptotic signaling, and therapeutic opportunities
- Review, Lung, NA
Apoptosis↑, ROS↑, Cyt‑c↑, Bcl-2↓, Casp↑, TumCP↓, TumCI↓, angioG↓, Inflam↓, ChemoSen↑, RadioS↑,
8671- MLT,    Targeting mitochondrial metabolism in renal cell carcinoma with melatonin: Preclinical evidence and clinical perspectives
- Review, RCC, NA
OXPHOS↑, Warburg↓, ROS↑, Akt↓, mTOR↓, NF-kB↓, HIF-1↓, VEGF↓, MAPK↓, TumCG↓, angioG↓, TumCI↓, Apoptosis↑, TumAuto↑, Synergy↑, *toxicity↓,
8692- MLT,    Melatonin as a Radio-Sensitizer in Cancer
- Review, Var, NA
RadioS↑, radioP↑, ROS↑, DNArepair↓, angioG↓, Inflam↓, Apoptosis↑, Telomerase↓, HSP70/HSPA5↑, P53↑, Glycolysis↓, Dose?, OS∅,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
1779- MLT,    Therapeutic Potential of Melatonin Counteracting Chemotherapy-Induced Toxicity in Breast Cancer Patients: A Systematic Review
- Review, BC, NA
QoL↑, OS↑, Dose∅, antiOx↑, ROS↑, SOD↑, Catalase↑, GPx↑, Risk↓, NK cell↑, IL1β↓, IL6↓, TNF-α↓, radioP↑, chemoP↑, TumVol↓, TumMeta↓, angioG↓, ChemoSen↑, eff↑,
8618- MO,    Lemon Balm Extracts Prevent Breast Cancer Progression In Vitro and In Ovo on Chorioallantoic Membrane Assay
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, selectivity?, Ingr↝, Dose↝, eff?, angioG↓, chemoPv↑,
8799- MT/VAE,    Antiangiogenic properties of viscum album extracts are associated with endothelial cytotoxicity
- vitro+vivo, Lung, EAhy926
angioG↓,

Showing Research Papers: 301 to 350 of 463
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 463

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,   NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 14,   antiOx⇅, 1,   ARE↓, 1,   Catalase↓, 2,   Catalase↑, 3,   Copper↓, 2,   Fenton↑, 4,   frataxin↑, 1,   GPx↑, 4,   GPx4↓, 4,   GSH↓, 28,   GSH↑, 3,   GSH⇅, 1,   GSH/GSSG↓, 1,   GSR↓, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   H2O2↓, 1,   H2O2↑, 4,   HO-1↓, 6,   HO-1↑, 10,   HO-2↓, 1,   Iron↑, 2,   Iron∅, 1,   Keap1↓, 2,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 15,   MDA↓, 3,   MDA↑, 2,   NOX↓, 1,   NQO1↑, 1,   NRF2↓, 17,   NRF2↑, 17,   Prx↓, 2,   Prx4↑, 1,   PrxI↓, 1,   PrxII↓, 1,   PYCR1↓, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 18,   ROS↑, 176,   ROS⇅, 3,   ROS↝, 5,   i-ROS↑, 1,   mt-ROS↑, 5,   SOD↓, 5,   SOD↑, 7,   SOD1↓, 2,   SOD1↑, 1,   SOD2↑, 2,   TBARS↑, 1,   Thiols↓, 3,   Trx↓, 2,   ox-Trx1↑, 1,   TrxR↓, 6,   TrxR1↓, 2,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

ATOX1↝, 1,   Ferritin↓, 2,   IronCh↑, 2,   NCOA4↑, 1,   Tf↓, 2,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR-ABL↓, 1,   CDC2↓, 3,   CDC25↓, 6,   compI↓, 3,   compII↓, 2,   EGF↓, 5,   ETC↓, 5,   HSP60/HSPD1↓, 2,   mitResp↓, 2,   Mortalin↓, 1,   mtDam↓, 1,   mtDam↑, 17,   OCR↓, 5,   OCR↑, 2,   OXPHOS↓, 2,   OXPHOS↑, 3,   PDH↓, 1,   PINK1↑, 1,   SDH↓, 1,   SIRT3↓, 1,   VDAC1↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 3,   AApath↓, 1,   ACC↓, 1,   ACC↑, 1,   ALAT↓, 3,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 17,   p‑AMPK↑, 1,   p‑AMT/GCST/T-protein↑, 1,   ARG↓, 1,   ATP↓, 15,   mt-ATP↓, 2,   CAIX/CA9↓, 1,   CBS↑, 1,   citrate↓, 1,   CPT1A↓, 1,   CYP4A/CYP4A11/CYP4A22↓, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 1,   FABP5/E-FABP↓, 1,   FASN↓, 5,   FASN↑, 1,   GAPDH↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 31,   GSK‐3β↓, 11,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 4,   Histones↑, 1,   HK2↓, 11,   HMG-CoA↓, 2,   lactateProd↓, 5,   LDHA↓, 4,   LDL↓, 3,   LDL↑, 1,   lipoGen↓, 1,   NADPH↓, 4,   NADPH↑, 2,   NPC1L1↓, 2,   O-Glc↓, 1,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 8,   p‑PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PDKs↓, 1,   PFK↓, 2,   PFK1↓, 1,   PFK2?, 1,   PKM2↓, 9,   PKM2↑, 1,   PKM2:PKM1↓, 1,   SIRT1↓, 8,   SIRT1↑, 9,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 2,   Warburg↓, 6,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 6,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 6,   Apoptosis↑, 180,   mt-Apoptosis↑, 3,   ASK1↑, 1,   BAD↓, 2,   BAD↑, 4,   Bak↑, 12,   BAX↓, 3,   BAX↑, 72,   BAX⇅, 1,   Bax:Bcl2↑, 22,   Bcl-2↓, 78,   Bcl-2↑, 2,   Bcl-xL↓, 27,   BID↓, 1,   BID↑, 3,   BIM↓, 1,   BIM↑, 5,   BNIP3↝, 1,   BOK↑, 1,   Casp↓, 2,   Casp↑, 34,   Casp↝, 1,   cl‑Casp↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3?, 1,   Casp3↓, 4,   Casp3↑, 95,   cl‑Casp3↑, 12,   proCasp3↑, 2,   Casp6↓, 1,   Casp6↑, 1,   Casp7↑, 15,   Casp8↓, 1,   Casp8↑, 23,   Casp8∅, 1,   cl‑Casp8↑, 3,   proCasp8↑, 1,   pro‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 62,   cl‑Casp9↑, 7,   cFLIP↓, 2,   Cupro↑, 2,   Cyt‑c↑, 66,   Cyt‑c↝, 2,   Diablo↑, 8,   DR5↑, 22,   FADD↑, 7,   Fas↓, 2,   Fas↑, 18,   FasL↑, 7,   Ferroptosis↑, 12,   GSDME↑, 1,   IAP1↓, 8,   IAP2/BIRC3↓, 5,   ICAD↓, 1,   ICD↑, 1,   iNOS↓, 11,   Mcl-1?, 1,   Mcl-1↓, 29,   MDM2↓, 10,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↓, 1,   MOMP↑, 5,   NAIP↓, 1,   Necroptosis↑, 4,   necrosis↑, 3,   NOXA↑, 4,   p38↓, 1,   p38↑, 13,   p‑p38↓, 3,   p‑p38↑, 2,   Paraptosis↑, 2,   PUMA↑, 6,   Pyro↑, 3,   RIP1↑, 1,   RIP3↑, 1,   survivin↓, 54,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAIL⇅, 1,   TRAILR↑, 2,   TumCD↑, 16,   XIAP↓, 28,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 123,   Akt↑, 8,   Akt↝, 1,   Akt∅, 1,   p‑Akt↓, 27,   AKT1↓, 2,   Akt2↓, 1,   BRAF↓, 1,   CK2↓, 3,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 1,   CREB2↓, 1,   cSrc↓, 1,   DDIT4↑, 1,   DYRK1B↓, 1,   EGFR↓, 28,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 36,   ERK↑, 8,   ERK↝, 2,   ERK∅, 1,   p‑ERK↓, 9,   p‑ERK↑, 1,   FGFR1↓, 2,   FOXD3↑, 2,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   Hippo↓, 1,   Hippo↝, 1,   IGF-1R↓, 3,   IGFR↓, 1,   IKKα↓, 6,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 5,   JAK1↓, 3,   JAK1↑, 1,   JAK2↓, 10,   JNK↓, 3,   JNK↑, 13,   JNK↝, 1,   p‑JNK↓, 2,   LIMK1↓, 1,   MAPK↓, 33,   MAPK↑, 11,   MAPK↝, 1,   MEK↓, 5,   mTOR↓, 74,   mTOR↑, 1,   p‑mTOR↓, 3,   mTORC2↓, 2,   mTORC2↑, 1,   p70S6↓, 1,   p‑p70S6↓, 1,   P70S6K↓, 5,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 89,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 2,   PI3K/Akt↓, 1,   p‑PI3k/Akt/mTOR↓, 1,   PKCδ↓, 10,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 2,   PTEN↑, 24,   p‑PTEN↓, 1,   Raf↓, 3,   RAS↓, 10,   SHP1↑, 1,   Sp1/3/4↓, 16,   STAT↓, 3,   STAT3↓, 59,   STAT3↑, 2,   STAT3↝, 1,   p‑STAT3↓, 9,   p‑STAT3↑, 2,   STAT5↓, 1,   STAT6↓, 3,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 3,   ATF4↝, 1,   CBP↓, 2,   cJun↓, 3,   cJun↑, 2,   cMyc↓, 34,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 6,   DNMT3A↓, 2,   DNMT3B↓, 2,   DNMTs↓, 6,   EZH2↓, 1,   FOXM1↓, 4,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 5,   FOXO3↑, 6,   FOXO3↝, 1,   p‑FOXO3↓, 2,   H3↓, 2,   p‑H3↓, 1,   ac‑H3↑, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 23,   HDAC1↓, 7,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC4↓, 2,   HDAC8↓, 2,   HES1↓, 2,   miR-106b↓, 1,   miR-107↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-194↑, 1,   miR-200b↑, 1,   miR-203↑, 1,   miR-205↑, 1,   miR-21↓, 5,   miR-21↑, 1,   miR-218↑, 1,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 1,   miR-34a↑, 2,   miR-34b-5p↑, 1,   miR-375↑, 1,   miR-384↑, 1,   miR-422a↑, 1,   Myc↓, 5,   MYCN↓, 1,   NDRG1↑, 1,   NEAT1↓, 1,   OCT4↓, 8,   other?, 1,   other↓, 4,   other↑, 4,   other↝, 14,   SOX2↓, 3,   SOX4↓, 1,   SOX4↑, 1,   SOX9↓, 1,   SUV39H↓, 2,   TFE3↑, 1,   tumCV↓, 29,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 17,   COX17↝, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↑, 3,   ER Stress↓, 2,   ER Stress↑, 35,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 9,   HSP27↓, 2,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 16,   HSP90↑, 1,   HTRA↓, 2,   PERK↑, 6,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↑, 4,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 2,   ATG5↑, 4,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 9,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↓, 1,   LC3B-II↑, 3,   LC3II↑, 10,   LC3s↑, 1,   p62↓, 4,   p62↑, 3,   p‑p62↑, 1,   PARK2↑, 1,   RUBCN↓, 1,   SESN2↑, 2,   TumAuto↓, 1,   TumAuto↑, 44,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   BRCA1↓, 3,   BRCA1↑, 2,   BRCA1↝, 1,   BRCA2↓, 1,   DFF45↓, 1,   DFF45↑, 2,   DNAdam↓, 3,   DNAdam↑, 48,   DNArepair↓, 5,   DNArepair↑, 1,   m-FAM72A↓, 1,   G9a↓, 1,   hTERT/TERT↓, 11,   MGMT↓, 1,   p16↑, 2,   P53?, 1,   P53↑, 64,   P53↝, 3,   p‑P53↑, 2,   PARP↓, 1,   PARP↑, 15,   cl‑PARP↓, 2,   cl‑PARP↑, 52,   PARP1↑, 1,   PCNA↓, 20,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 15,   TOP1↓, 8,   TOP2↓, 6,   TOP2↑, 1,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 9,   CDK1↑, 2,   p‑CDK1↓, 2,   CDK2↓, 31,   CDK2↑, 2,   CDK4↓, 34,   CDK4↑, 2,   CDK4/6↓, 1,   CDK6↓, 17,   CDK6↑, 2,   CDK7↓, 1,   CDK8↓, 1,   CHK1↓, 1,   CHK1↑, 2,   Chk2↓, 1,   Chk2↑, 2,   Cyc↓, 3,   cycA1/CCNA1↓, 7,   CycB/CCNB1↓, 17,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 55,   CycD3↓, 3,   cycE/CCNE↓, 19,   cycE1↓, 1,   E2Fs↓, 5,   E2Fs↑, 1,   GADD45A↓, 1,   Ki-67↓, 21,   mitA↓, 1,   mitA↑, 1,   p19↑, 1,   P21?, 1,   P21↓, 2,   P21↑, 42,   p27/CDKN1B↑, 19,   pRB↑, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 5,   Securin↓, 1,   TubPol↓, 1,   TumCCA?, 1,   TumCCA↓, 7,   TumCCA↑, 156,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 3,   p‑4E-BP1↓, 1,   ALDH↓, 8,   Axin2↑, 1,   BMPs↑, 2,   CD133↓, 4,   CD133↑, 1,   CD24↓, 1,   CD34↓, 1,   cFos↓, 6,   cMYB↓, 2,   CSCs?, 1,   CSCs↓, 45,   CSCs↑, 2,   Diff↑, 4,   FGF↓, 2,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 5,   HH↓, 10,   HH∅, 1,   HMGCR↓, 1,   IGF-1↓, 10,   IGF-2↓, 1,   IGFBP3↑, 4,   Jun↓, 1,   Ki-67↓, 21,   Let-7↑, 2,   mTORC1↓, 5,   Nanog↓, 6,   Nestin↓, 1,   NICD↓, 1,   NOTCH↓, 11,   NOTCH1↓, 8,   NOTCH1↑, 3,   OGF↑, 1,   OGFr↑, 1,   p300↓, 2,   PTCH1↓, 1,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 3,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 87,   TumCG↑, 1,   TumCP↓, 145,   TumCP↑, 6,   tyrosinase↓, 1,   Wnt↓, 35,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   annexin II↓, 1,   AntiAg?, 1,   AP-1↓, 8,   ARG1/2↑, 1,   ASAP2↓, 1,   AXL↓, 1,   CA↓, 3,   Ca+2↓, 3,   Ca+2↑, 24,   Ca+2↝, 5,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↓, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   Chl↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   COL4A3↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 29,   EM↑, 1,   EMT↓, 64,   EMT↑, 2,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 18,   p‑FAK↓, 4,   p‑FAK↑, 1,   Fibronectin↓, 2,   GLI2↓, 1,   GLI3↓, 1,   IQGAP3↓, 1,   ITGB1↓, 2,   ITGB3↓, 3,   ITGB6↓, 1,   KRAS↓, 1,   LEF1↓, 1,   MALAT1↓, 2,   MET↓, 1,   MMP-10↓, 2,   MMP1↓, 9,   MMP13↓, 3,   MMP14↓, 1,   MMP16↓, 2,   MMP2?, 1,   MMP2↓, 73,   MMP3↓, 9,   MMP7↓, 9,   MMP9?, 1,   MMP9↓, 91,   MMP9↑, 2,   MMPs↓, 39,   MUC4↓, 2,   N-cadherin↓, 17,   NEDD9↓, 1,   p‑p44↓, 1,   PAK1↓, 1,   PAK1↑, 1,   pax↓, 1,   PDGF↓, 10,   Rac1↓, 3,   RECK↑, 3,   Rho↓, 5,   Rho↑, 1,   ROCK1↓, 4,   ROCK1↑, 1,   Slug↓, 9,   Smad1↓, 2,   Smad1↝, 1,   p‑SMAD2↓, 1,   SMAD3↓, 2,   p‑SMAD3↓, 1,   Snail?, 1,   Snail↓, 16,   STAC2↓, 1,   TET1↑, 2,   TGF-β↓, 17,   TGF-β↑, 1,   TGF-β↝, 1,   TGF-β1↓, 2,   TIMP1↑, 10,   TIMP2↓, 1,   TIMP2↑, 13,   TIMP3↑, 1,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 9,   TumCA↓, 1,   TumCI↓, 97,   TumCI↑, 1,   TumCMig↓, 76,   TumCMig↑, 3,   TumMeta?, 1,   TumMeta↓, 119,   TumMeta↑, 7,   Twist↓, 16,   TXNIP↑, 1,   uPA↓, 18,   uPAR↓, 2,   Vim↓, 24,   Zeb1↓, 7,   ZEB2↓, 2,   α-SMA↓, 2,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 39,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 420,   angioG↑, 10,   angioG∅, 1,   angioS↑, 1,   CD31/PECAM-1↓, 11,   EGR1↑, 1,   Endoglin↓, 1,   Endoglin↑, 1,   eNOS↓, 3,   HIF-1↓, 10,   Hif1a↓, 83,   Hif1a↑, 1,   Hif1a↝, 1,   LymphAG↓, 1,   NO↓, 3,   NO↑, 1,   TYMP/ECGF1↓, 1,   VCAM-1↓, 2,   VEGF↓, 173,   VEGF↑, 2,   VEGFR1↓, 4,   VEGFR2/KDR/Flk1↓, 31,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 8,   CLDN1↓, 2,   CLDN1↑, 1,   CLDN2↓, 1,   CTR1↝, 1,   CX43/GJA1↓, 1,   EPR↑, 10,   GLUT1↓, 12,   GLUT2↓, 1,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 78,   MMP↑, 2,   MMP↝, 1,   MPT↑, 5,   NHE1↓, 2,   OCLN↑, 1,   TJ↑, 1,   TRPV1↑, 2,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↓, 1,   CD44↓, 13,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 65,   COX2/PTGS2↑, 2,   CXCL16↓, 1,   CXCL6/GCP-2↓, 1,   CXCR2↓, 2,   CXCR4↓, 14,   DCells↑, 1,   DR4↑, 9,   Gal-3↓, 2,   GM-CSF↓, 3,   HLA-I/II↑, 1,   ICAM-1↓, 7,   IFN-γ↓, 2,   IFN-γ↑, 3,   Igs↑, 1,   IL1↓, 6,   IL10↓, 4,   IL10↑, 2,   IL12↓, 1,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 15,   IL2↓, 2,   IL2↑, 5,   IL4↓, 2,   IL4↑, 1,   IL6↓, 32,   IL8↓, 9,   Imm↑, 21,   Imm↝, 6,   INF-γ↑, 1,   Inflam↓, 44,   Inflam↝, 1,   LIF↑, 1,   LRIG1↑, 1,   M2 MC↓, 2,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 6,   MCT1↓, 1,   MDSCs↓, 2,   MIP2↓, 1,   mPGES-1↓, 2,   MyD88↓, 1,   MyD88↑, 1,   NAF1↓, 1,   NF-kB↓, 137,   NF-kB↑, 3,   NF-kB↝, 2,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 7,   NLRP3↓, 4,   NLRP3↑, 1,   p50↓, 1,   p65↓, 1,   PD-L1↓, 7,   PGE2↓, 16,   PSA↓, 6,   PSA∅, 1,   RAGE↓, 2,   SOCS-3↓, 1,   T-Cell↑, 1,   T-Cell↝, 1,   TCF↓, 3,   TCF↝, 1,   Th1 response↑, 1,   Th2↑, 1,   TLR4↓, 6,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 34,   TNF-α↑, 3,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRAF1↓, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,   pH↝, 1,   e-pH↑, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AR↓, 12,   CYP17A1↓, 1,   CYP19↓, 2,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   Estro↝, 1,   FGF21↓, 2,   GR↑, 1,   PPARα↓, 2,   cl‑PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   BioAv↓, 50,   BioAv↑, 58,   BioAv↝, 8,   BioEnh↑, 5,   CBR1↓, 1,   chemoR↓, 1,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 159,   ChemoSen⇅, 1,   ChemoSen∅, 1,   CompStab?, 1,   CompStab↓, 3,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 3,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 3,   DDS↑, 5,   Dose?, 4,   Dose↓, 4,   Dose↑, 3,   Dose⇅, 1,   Dose↝, 53,   Dose∅, 8,   DrugR↓, 2,   eff?, 1,   eff↓, 30,   eff↑, 98,   eff↝, 10,   eff∅, 3,   GSTZ1↓, 1,   Half-Life↓, 16,   Half-Life↑, 5,   Half-Life↝, 9,   Half-Life∅, 2,   MDR1↓, 11,   MRP1/ABCC1↓, 3,   NAT↓, 1,   P-gp/ABCB1↓, 20,   P-gp/ABCB1↝, 1,   P450↓, 4,   RadioS?, 2,   RadioS↑, 49,   selectivity?, 1,   selectivity↑, 65,   Synergy↑, 100,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   AFP↑, 1,   ALAT↓, 3,   ALP↓, 3,   AR↓, 12,   ascitic↓, 2,   AST↓, 2,   BRAF↓, 1,   BRCA1↓, 3,   BRCA1↑, 2,   BRCA1↝, 1,   CEC↝, 1,   CIT↓, 1,   CRP↓, 2,   CTC↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 28,   EGFR↝, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 1,   Ferritin↓, 2,   FOXM1↓, 4,   HemoG↓, 1,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 11,   IL6↓, 32,   KRAS↓, 1,   LDH↓, 6,   LDH↑, 2,   Maspin↑, 1,   Myc↓, 5,   NOS2↓, 1,   PD-L1↓, 7,   PSA↓, 6,   PSA∅, 1,   RAGE↓, 2,   TP53↑, 3,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 60,   AntiCan∅, 1,   antiNeop↑, 3,   AntiTum↑, 23,   cardioP↑, 10,   CardioT↓, 1,   CardioT↑, 2,   chemoP↑, 29,   chemoPv↑, 25,   ChemoSideEff↓, 5,   fatigue↓, 3,   fatigue∅, 1,   hepatoP↓, 1,   hepatoP↑, 9,   Mucositis↓, 1,   neuroP↑, 8,   OS↑, 19,   OS∅, 1,   Pain↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 8,   QoL∅, 1,   radioP↑, 10,   Remission↑, 3,   RenoP↑, 7,   Risk↓, 19,   Risk↑, 2,   Sleep↑, 1,   toxicity↓, 27,   toxicity↑, 4,   toxicity↝, 11,   toxicity∅, 1,   TumNum?, 1,   TumVol↓, 26,   TumVol∅, 1,   TumW↓, 15,   TumW∅, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 1,   GutMicro↑, 6,   GutMicro↝, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 996

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 6,   antiOx↑, 75,   Catalase↑, 25,   DPPH↓, 1,   GPx↑, 20,   GPx1↑, 3,   GPx4↑, 2,   GSH↑, 20,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 9,   H2O2↓, 2,   HDL↑, 1,   HNE↓, 1,   HO-1↑, 11,   i-Iron↓, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↓, 23,   MDA↓, 13,   MPO↓, 1,   NADH↓, 1,   NOX4↓, 1,   Nrf1↑, 2,   NRF2↑, 24,   RNS↓, 1,   ROS↓, 79,   ROS↑, 2,   ROS∅, 1,   SAM-e↑, 1,   selenoP↑, 1,   SOD↑, 27,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 3,   TBARS↓, 1,   TOS↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   OXPHOS↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 4,   5LO↝, 1,   ALAT?, 1,   ALAT↓, 5,   AMPK↓, 1,   AMPK↑, 3,   ATP↑, 1,   ATP↝, 1,   BHB↑, 1,   cytoP450↓, 1,   glucose↓, 5,   GlucoseCon↑, 1,   Glycolysis↑, 1,   GSK‐3β↓, 2,   HK2↑, 1,   LDHA↑, 1,   LDL↓, 5,   lipidLev↓, 1,   NAD↝, 1,   NADPH↑, 1,   PFKL↑, 1,   PFKM↑, 1,   PFKP↑, 1,   PKM2↑, 1,   SIRT1↑, 7,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   ASC?, 1,   BAX↓, 2,   Bcl-2↑, 1,   Casp1↓, 1,   Casp3↓, 5,   Casp9↓, 3,   Cyt‑c↓, 2,   Ferroptosis↓, 1,   iNOS↓, 10,   iNOS↑, 1,   p38↓, 3,   Pyro?, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 1,   AKT1↑, 1,   p‑CREB↑, 1,   ERK↓, 1,   ERK↑, 2,   JAK2↓, 1,   JNK↓, 1,   JNK↑, 1,   p‑JNK↓, 2,   p‑LIMK1↑, 1,   MAPK↓, 4,   MAPK↑, 2,   p‑MEK↑, 1,   mTOR↓, 1,   mTOR↑, 1,   PDGFR-BB↑, 1,   PI3K↓, 1,   PI3K↑, 2,   PKCδ↑, 1,   Sp1/3/4↓, 1,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF4↓, 1,   cMyc↓, 2,   HDAC↓, 1,   OCT4↓, 1,   other↓, 4,   other↑, 5,   other↝, 6,   SOX18↑, 1,   SOX9↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 1,   ER Stress↓, 3,   GRP78/BiP↓, 1,   HSP70/HSPA5↑, 2,   HSPs↑, 1,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   GADD45A↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CD133↑, 1,   Diff↑, 1,   FGF↑, 2,   IGF-1↑, 1,   MSCs↑, 1,   neuroG↑, 2,   TumCP↓, 4,   tyrosinase↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   Ca+2↓, 2,   Ca+2↑, 1,   Ca+2↝, 2,   p‑Cofilin↑, 1,   COL1↑, 1,   COL2A1↑, 1,   EMT↓, 1,   FAK↑, 1,   ITGB1↑, 1,   p‑MLC2/MYL9↑, 1,   MMP13↓, 1,   MMP2↓, 2,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 2,   MMP9↑, 2,   MYPT1 / PPP1R12A↑, 1,   p‑MYPT1 / PPP1R12A↑, 1,   N-cadherin↑, 1,   Rac1↑, 1,   Rho↓, 1,   ROCK1↑, 1,   serineP↓, 1,   Snail↑, 1,   TGF-β↓, 1,   TGF-β↑, 3,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP2↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   Twist↑, 1,   uPA↓, 1,   Vim↑, 1,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 14,   angioG↑, 28,   angioG↝, 1,   CD31/PECAM-1↑, 1,   E-sel↓, 1,   eNOS↓, 2,   eNOS↑, 2,   Hif1a↓, 2,   Hif1a↑, 4,   NO↓, 8,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 8,   VEGF↑, 12,   VEGFR2/KDR/Flk1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 6,   CLDN5↑, 1,   GastroP↑, 1,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   ketosis↑, 1,   MMP↑, 4,   MMP↝, 1,   MMP∅, 1,   OATPs↓, 1,   VGCC↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 23,   CXCR4↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 2,   IL10↑, 3,   IL12↓, 1,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 12,   IL2↓, 1,   IL4↓, 1,   IL6↓, 16,   IL6↑, 1,   IL8↓, 1,   Imm↑, 6,   Imm⇅, 1,   Imm↝, 1,   Inflam↓, 87,   Inflam↑, 3,   IRF3↓, 2,   MCP1/CCL2↓, 1,   MyD88↓, 2,   NF-kB↓, 22,   NK cell↑, 1,   NLRP3↓, 3,   p65↓, 1,   PGE2↓, 9,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 3,   TLR4↓, 3,   TLR4∅, 1,   TNF-α↓, 20,   TNF-α↑, 1,   TRIF↓, 1,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 7,   BChE↓, 1,   BDNF↑, 1,   GABA↑, 2,   GABA↝, 1,   MAOA↓, 1,   MAOB↓, 2,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 9,   BACE/β-secretase↓, 1,   tau↓, 3,   p‑tau↓, 3,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↓, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 27,   BioAv↑, 29,   BioAv⇅, 1,   BioAv↝, 14,   BioAv∅, 1,   BioEnh↑, 2,   CompStab↑, 2,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 8,   Dose∅, 1,   eff↑, 8,   eff↝, 2,   GSTA1↑, 2,   Half-Life↑, 2,   Half-Life↝, 5,   Half-Life∅, 3,   P450↓, 1,   selectivity↑, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 5,   ALP↓, 2,   ascitic↓, 1,   AST↓, 7,   BloodF↑, 1,   BMD↑, 3,   BP↓, 2,   Calcium↑, 1,   CRP↓, 4,   hs-CRP↓, 1,   IL6↓, 16,   IL6↑, 1,   LDH↓, 4,   Mag↑, 1,   NOS2↓, 1,   TC↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 6,   AntiArt↑, 3,   AntiCan↓, 2,   AntiCan↑, 10,   AntiDiabetic↓, 1,   AntiDiabetic↑, 17,   AntiTum↓, 1,   AntiTum↑, 2,   Bone Healing↑, 1,   cardioP↑, 30,   cardioP⇅, 1,   chemoP↑, 3,   chemoPv↑, 3,   ChemoSideEff↓, 2,   cognitive↓, 1,   cognitive↑, 8,   diuretic↑, 1,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 25,   memory↑, 11,   Mood↑, 1,   motorD↑, 2,   neuroP?, 1,   neuroP↓, 2,   neuroP↑, 43,   Obesity↓, 5,   OS↑, 1,   Pain↓, 3,   PDE4↓, 1,   radioP↑, 3,   RenoP↑, 5,   Risk↓, 2,   Sleep↑, 1,   Stress↓, 1,   Stroke↓, 3,   Stroke↝, 1,   toxicity↓, 31,   toxicity↑, 3,   toxicity↝, 7,   toxicity∅, 8,   Weight↓, 1,   Wound Healing↑, 5,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 8,   AntiFungal↑, 4,   AntiP↑, 4,   AntiViral↑, 8,   Bacteria↓, 17,   Bacteria↑, 1,   GutMicro↑, 11,   GutMicro↝, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,  
Total Targets: 360

Scientific Paper Hit Count for: angioG, angiogenesis
14 Magnetic Fields
14 Thymoquinone
12 itraconazole
11 Curcumin
11 Chrysin
9 Fisetin
9 Fucoidan
9 MCT, metronomic chemo
9 Resveratrol
9 Sulforaphane (mainly Broccoli)
9 Silymarin (Milk Thistle) silibinin
8 Artemisinin
8 Propolis -bee glue
8 Copper and Cu NanoParticles
8 Kaempferol
8 Quercetin
8 Luteolin
7 Ashwagandha(Withaferin A)
7 Betulinic acid
7 Cinnamon
7 Radiotherapy/Radiation
7 Eugenol
7 Nimbolide
6 Capsaicin
5 Silver-NanoParticles
5 Apigenin (mainly Parsley)
5 Berberine
5 chitosan
5 Ellagic acid
5 EGCG (Epigallocatechin Gallate)
5 Formononetin
5 Gambogic Acid
5 Magnolol
5 Melatonin
5 Selenite (Sodium)
4 immunotherapy
4 Beta-Caryophyllene
4 Boswellia (frankincense)
4 Rosmarinic acid
4 Celastrol
4 D-limonene
4 Disulfiram
4 Isoliquiritigenin
4 Lycopene
4 Phenethyl isothiocyanate
3 Carvacrol
3 Chlorogenic acid
3 Hydroxycinnamic-acid
3 Coenzyme Q10
3 Crocetin
3 Dichloroacetate
3 Emodin
3 Ferulic acid
3 Gallic acid
3 phytic acid, Inositol hexakisphosphate
3 Ivermectin
3 Juglone
3 mebendazole
3 methylseleninic acid
3 Piperlongumine
3 tetrathiomolybdate
2 3-bromopyruvate
2 chemodynamic therapy
2 Allicin (mainly Garlic)
2 Alpha-Lipoic-Acid
2 Chemotherapy
2 beta-glucans
2 Baicalein
2 Boron
2 Caffeic acid
2 Carnosic acid
2 chaetocin
2 Carica papaya leaf extract
2 Cucurbitacin
2 Deguelin
2 Diclofenac
2 Dipyridamole
2 Dandelion Root
2 Ginkgo biloba-EGb 761
2 Flaxseed/Linseed
2 Garcinol
2 Ginkgolide B
2 Helleborus niger extracts – Christmas Rose
2 Honokiol
2 HydroxyTyrosol
2 isoflavones
2 Isovitexin
2 Licochalcone A
2 SDG/lignans
2 Linalool
2 Modified Citrus Pectin
2 Mistletoe/Viscum album Extracts
2 Naringin
2 Piperine
2 Pterostilbene
2 α-Santalol/Sandalwood oil
2 Selenium
2 Selenium NanoParticles
2 Ursolic acid
1 Annona atemoya Seed Extract
1 Auranofin
1 Astragalus
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Aspirin
1 Ascorbyl Palmitate
1 Atorvastatin
1 Aloe anthraquinones
1 Biochanin A
1 Bufalin/Huachansu
1 borneol
1 urea
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Sorafenib (brand name Nexavar)
1 Carnosine
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chocolate
1 Metformin
1 Citric Acid
1 Vitamin E
1 diet FMD Fasting Mimicking Diet
1 diet Ketogenic
1 Diindolylmethane
1 Zinc
1 Echinacea
1 Electrical Pulses
1 flavonoids
1 olaparib/LYNPARZA
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 Gossypol/AT-101
1 Hydrogen Gas
1 hydrogen sulfide
1 Hibiscus sabdariffa
1 Hops (Humulus lupulus)
1 isoorientin
1 Vitexin
1 low dose naltrexone
1 Docetaxel
1 Matrine
1 Sulindac
1 Paclitaxel/Taxol
1 Methyl Jasmonate
1 vp16, etoposide
1 Magnetic Field Rotating
1 Lemon Balm/Melissa officinalis
1 Neem
1 Oroxylin-A
1 Oleuropein
1 Oleocanthal
1 Marjoram (Origanum majorana)
1 Oregano
1 Phenylbutyrate
1 Plumbagin
1 Psoralidin
1 Ramucirumab (CYRAMZA)
1 Rutin
1 buckwheat sprouts
1 Salvia officinalis
1 salinomycin
1 Shikonin
1 Theobromine
1 Aflavin-3,3′-digallate
1 Thymol-Thymus vulgaris
1 Urolithin
1 Usnic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:447  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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