Catalase Cancer Research Results

Catalase, Catalase: Click to Expand ⟱
Source:
Type:
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Caspase-1 may have both tumorigenic or antitumorigenic effects on cancer development and progression, but it depends on the type of inflammasome, methodology, and cancer.
Catalase is an enzyme found in nearly all living cells exposed to oxygen. Its primary role is to protect cells from oxidative damage by catalyzing the conversion of hydrogen peroxide (H₂O₂), a potentially damaging byproduct of metabolism, into water (H₂O) and oxygen (O₂). This detoxification process is crucial because excess H₂O₂ can lead to the formation of reactive oxygen species (ROS) that damage proteins, lipids, and DNA.

Catalase and Cancer
Oxidative Stress and Cancer:
Cancer cells often experience increased levels of oxidative stress due to rapid proliferation and metabolic changes. This stress can lead to DNA damage, promoting tumorigenesis.
Catalase helps mitigate oxidative stress, and its expression can influence the survival and proliferation of cancer cells.
Expression Levels in Different Cancers:
Overexpression: In some cancers, such as breast cancer and certain types of leukemia, catalase may be overexpressed. This overexpression can help cancer cells survive in oxidative environments, potentially leading to more aggressive tumor behavior.
Downregulation: Conversely, in other cancers, such as colorectal cancer, reduced catalase expression has been observed. This downregulation can lead to increased oxidative stress, contributing to tumor progression and metastasis.
Prognostic Implications:
Survival Rates: Studies have shown that high levels of catalase expression can be associated with poor prognosis in certain cancers, as it may enable cancer cells to resist apoptosis (programmed cell death) induced by oxidative stress.

Some types of cancer cells have been reported to exhibit lower catalase activity, possibly increasing their vulnerability to oxidative damage under certain conditions. This vulnerability has even been exploited in some therapeutic strategies (for example, approaches that generate excess H₂O₂ or other ROS specifically targeting cancer cells have been researched).
Scientific Papers found: Click to Expand⟱
3184- SFN,    The Integrative Role of Sulforaphane in Preventing Inflammation, Oxidative Stress and Fatigue: A Review of a Potential Protective Phytochemical
- Review, Nor, NA
*NRF2↑, *Inflam↓, *NF-kB↓, *ROS↓, *BioAv↝, *BioAv↝, *BioAv↝, *BioAv↝, *cardioP↑, *GPx↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *NADPH↑, *NQO1↑, *LDH↓, *hepatoP↑, *ALAT↓, *AST↓, *IL6↓,
2444- SFN,    Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage
- in-vitro, Nor, MRC-5
*GlucoseCon↓, *ROS↓, *Trx↓, *HK2↓, *NRF2↑, *Catalase↑, *TXNIP↑, *PFKFB2↓, *G6PD↑,
2553- SFN,    Mechanistic review of sulforaphane as a chemoprotective agent in bladder cancer
- Review, Bladder, NA
antiOx↓, Inflam↓, ChemoSen↑, ROS⇅, *NRF2↑, *GSH↑, Catalase↑, HO-1↑, NAD↑, chemoP↑,
3315- SIL,    Silymarin alleviates docetaxel-induced central and peripheral neurotoxicity by reducing oxidative stress, inflammation and apoptosis in rats
- in-vivo, Nor, NA
neuroP↑, *NRF2↑, *HO-1↑, *lipid-P↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *NF-kB↓, *TNF-α↓, *JNK↓, *Bcl-2↑, *BAX↑,
3307- SIL,    Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications
- Review, Var, NA
*NRF2↑, *antiOx↑, *chemoP↑, *Inflam↓, *BioAv↑, Synergy↑, *NQO1↑, TNF-α↓, IL6↓, *GSH↑, *ROS↓, *MDA↓, Synergy↑, *hepatoP↑, *GPx↑, *SOD↑, *Catalase↑, *HO-1↑, *neuroP↑,
3310- SIL,    Silymarin attenuates paraquat-induced lung injury via Nrf2-mediated pathway in vivo and in vitro
- in-vitro, Lung, A549
Inflam↓, MPO↓, NO↓, iNOS↓, ROS↓, MDA↑, SOD↑, Catalase↑, GPx↑, NRF2↑, HO-1↑, NADPH↑,
3300- SIL,    Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy
- Review, Var, NA
*ROS↓, *SOD↑, *hepatoP↑, *AST↓, *ALAT↓, *lipid-P↓, *GSH↑, *Catalase↑, *GSTs↑, *GSR↑, *TNF-α↓, *IFN-γ↓, *IL4↓, *IL2↓, *NF-kB↓, *IL10↑, *Inflam↓, COX2/PTGS2↓, Apoptosis↑, ChemoSen↑, PGE2↓, VEGF↓,
4205- SIL,    The Therapeutic Effect of Silymarin and Silibinin on Depression and Anxiety Disorders and Possible Mechanism in the Brain: A Systematic Review
- Review, AD, NA
*BDNF↑, *5HT↑, *MDA↓, *GSH↑, *SOD↑, *Catalase↑, *IL6↓, *IL1β↓,
3318- SIL,    Pharmaceutical prospects of Silymarin for the treatment of neurological patients: an updated insight
- Review, AD, NA - Review, Park, NA
*hepatoP↑, *neuroP↑, *TLR4↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *memory↑, *cognitive↑, *NRF2↑, *HO-1↑, *ROS↓, *Akt↑, *mTOR↑, *SOD↑, *Catalase↑, *GSH↑, *IL10↑, *IL6↑, *NO↓, *MDA↓, *AChE↓, *MAPK↓, *BDNF↑,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2/PTGS2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,
3040- SK,    Pharmacological Properties of Shikonin – A Review of Literature since 2002
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA
*Half-Life↝, *BioAv↓, *BioAv↑, *BioAv↑, *Inflam↓, *TNF-α↓, *other↑, *MPO↓, *COX2/PTGS2↓, *NF-kB↑, *STAT3↑, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *Catalase↑, *GPx↑, *Bcl-2↑, *BAX↓, cardioP↑, AntiCan↑, NF-kB↓, ROS↑, PKM2↓, TumCCA↑, Necroptosis↑, Apoptosis↑, DNAdam↑, MMP↓, Cyt‑c↑, LDH↝,
1344- SK,    Novel multiple apoptotic mechanism of shikonin in human glioma cells
- in-vitro, GBM, U87MG - in-vitro, GBM, Hs683 - in-vitro, GBM, M059K
ROS↑, GSH↓, MMP↓, P53↑, cl‑PARP↑, Catalase↓, SOD1↑, Bcl-2↓, BAX↑, eff↓,
1345- SK,    The Critical Role of Redox Homeostasis in Shikonin-Induced HL-60 Cell Differentiation via Unique Modulation of the Nrf2/ARE Pathway
- in-vitro, AML, HL-60
CD14↑, CD11b↑, ROS↑, GSH↓, GSH/GSSG↓, GPx↑, Catalase↓, Diff↑,
984- SSE,    Effects of selenite on estrogen receptor-alpha expression and activity in MCF-7 breast cancer cells
- in-vitro, BC, MCF7
ERα/ESR1↓, PR↑, pS2/TFF1↑, Catalase↑,
4731- SSE,    Dietary selenium mitigates cadmium-induced apoptosis and inflammation in chicken testicles by inhibiting oxidative stress through the activation of the Nrf2/HO-1 signaling pathway
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *H2O2↓, *Catalase↑, *GSH↑, *NRF2↑, *HO-1↑, *Bcl-2↑, *other↝,
3960- Taur,    Versatile Triad Alliance: Bile Acid, Taurine and Microbiota
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *Inflam↓, *GABA↑, *memory↑, *cognitive↑, *iNOS↓, *CRP↓, *HO-1↑, *Prx↑, *Trx↑, *NRF2↑, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *MDA↓, *eff↝, *GutMicro↑, other↑,
1937- TQ,    Migration and Proliferation Effects of Thymoquinone-Loaded Nanostructured Lipid Carrier (TQ-NLC) and Thymoquinone (TQ) on In Vitro Wound Healing Models
- in-vitro, Wounds, 3T3
*ROS↓, *antiOx↓, *BioAv↓, *BioAv↑, *NO↑, *SOD↑, *GPx↑, *Catalase↑,
2121- TQ,    Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
p‑p38↑, ROS↑, TumCP↓, ChemoSen↑, XIAP↓, survivin↓, Bcl-xL↓, Bcl-2↓, Ki-67↓, *Catalase↑, *SOD↑, *GSH↑, hepatoP↑, p‑MAPK↑, JNK↓, eff↓,
2086- TQ,    Cardioprotective effects of Nigella sativa oil on cyclosporine A-induced cardiotoxicity in rats
- in-vivo, Nor, NA
*SOD↑, *Catalase↑, *GSH↑, *cardioP↑, *lipid-P↓,
2087- TQ,    Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats
- in-vivo, Nor, NA
*LDL↓, *SOD1↑, *Catalase↑, *GPx↑, *antiOx↑,
2088- TQ,    Nigella sativa L. and Its Bioactive Constituents as Hepatoprotectant: A Review
- Review, Nor, NA
*hepatoP↑, *lipid-P↓, *Thiols↑, *ROS↓, *Catalase↑, *SOD↑, *GSTs↑, *NF-kB↓, *COX2/PTGS2↓, *LOX1↓,
2089- TQ,    Modulation of Hydrogen Peroxide-Induced Oxidative Stress in Human Neuronal Cells by Thymoquinone-Rich Fraction and Thymoquinone via Transcriptomic Regulation of Antioxidant and Apoptotic Signaling Genes
- in-vitro, Nor, SH-SY5Y
*neuroP↑, *ROS↓, *SOD1↑, *Catalase↑,
2092- TQ,    Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease
- Review, AD, NA
*iNOS↓, *ROS↓, *GSH↑, *neuroP↑, *MMPs↓, *MMP↑, *TXNIP↓, *Prx↑, *memory↑, *MDA↓, *SOD↑, *Catalase↑, *BioAv↑,
2106- TQ,    Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy
- Review, Var, NA
Apoptosis↑, TumCCA↑, ROS↑, *Catalase↑, *SOD↑, *GR↑, *GSTA1↓, *GPx↑, *H2O2↓, *ROS↓, *lipid-P↓, *HO-1↑, p‑Akt↓, AMPKα↑, NK cell↑, selectivity↑, Dose↝, eff↑, GSH↓, eff↓, P53↑, p‑STAT3↓, PI3K↑, MAPK↑, GSK‐3β↑, ChemoSen↑, RadioS↑, BioAv↓, NRF2↑,
3410- TQ,    Anti-inflammatory effects of thymoquinone and its protective effects against several diseases
- Review, Arthritis, NA
*Inflam↓, *antiOx↑, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL6↓, *TNF-α↓, *IFN-γ↓, *PGE2↓, *cardioP↑, *Catalase↑, *SOD↑, *Thiols↑, *neuroP↑, *IL12↓, *MCP1/CCL2↓, *CXCc↓, *ROS↓, *antiAll↑,
3404- TQ,    The Neuroprotective Effects of Thymoquinone: A Review
- Review, Var, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *TNF-α↓, *IL6↓, *IL1β↓, *NF-kB↓, *iNOS↓, *NRF2↑, *neuroP↑, *MMP↑, *ROS↓, *MDA↓, *GSH↑, *Catalase↑, *SOD↑, *IL12↓, *MCP1/CCL2↓, *IP-10/CXCL-10↓, *PGE2↓, *antiAll?,
3400- TQ,  Chemo,    Thymoquinone Ameliorates Carfilzomib-Induced Renal Impairment by Modulating Oxidative Stress Markers, Inflammatory/Apoptotic Mediators, and Augmenting Nrf2 in Rats
- in-vitro, Nor, NA
*GSH↑, *SOD↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *Casp3↓, *Catalase↑, *NRF2↑, *RenoP↑,
3399- TQ,    Anticancer Effects of Thymoquinone through the Antioxidant Activity, Upregulation of Nrf2, and Downregulation of PD-L1 in Triple-Negative Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - NA, BC, MDA-MB-468
ROS↓, H2O2↓, Catalase↑, SOD↑, GSH↑, NQO1↑, GCLM↑, NRF2↑, PD-L1↓, GSSG↑, GPx1⇅, GPx4↓,
3398- TQ,  5-FU,    Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo
- in-vivo, Nor, NA
*RenoP↑, *TAC↑, *ROS↓, *lipid-P↓, *p38↓, *MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *MDA↓, *GPx↑, *GSR↑, *Catalase↑, *BUN↓, *LDH↓, *IL1β↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, CompStab↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2/PTGS2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
5024- TQ,    Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?
- Review, Covid, NA
*NRF2↑, *NF-kB↓, *Inflam↓, *ROS↓, *HO-1↑, antiOx↑, GSH↑, GSTs↑, GSR↑, SOD1↑, Catalase↑, GPx↑, p62↓, Beclin-1/ATG6↑, Sepsis↓, cardioP↑, hepatoP↑, neuroP↑,
4538- TQ,    Thymoquinone Anticancer Effects Through the Upregulation of NRF2 and the Downregulation of PD‐L1 in MDA‐MB‐231 Triple‐Negative Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
antiOx↑, H2O2↓, Catalase↑, SOD↑, GSH↑, PRNP↑, NQO1↑, GCLM↑, NRF2↑, PD-L1↓, chemoPv↑, ROS↓,
6460- TUR,  CUR,    Neuroprotective Effect of Turmeric Extract in Combination with Its Essential Oil and Enhanced Brain Bioavailability in an Animal Model
- in-vivo, AD, NA
*memory↑, *lipid-P↓, *GSH↑, *AChE↑, *Catalase↑, *BioAv↑, *P-gp/ABCB1↓, *BioAv↑, *SOD↑, *BBB↑, *ROS↓,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31/PECAM-1↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *Synergy↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4876- Uro,    Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management
- Review, Park, NA - Review, AD, NA
*Inflam↓, *antiOx↓, *neuroP↑, *p‑tau↓, *Aβ↓, *Synergy↑, *BioAv↓, *BioAv↑, *GSH↑, *SOD↑, *lipid-P↓, *Catalase↑, *GSR↑, *GPx↑, *ROS↓, *NRF2↑, *GutMicro↑, *Risk↓, *BBB↓, *NLRP3↓, *MAOA↓,
4880- Uro,    Urolithins: A Prospective Alternative against Brain Aging
- Review, AD, NA
*cognitive↑, *memory↑, *antiOx↑, *BBB↑, *ROS↓, *lipid-P↓, *Catalase↑, *SOD↑, *GSR↑, *GPx↑, *CREB↑, *BDNF↑, *neuroP↑, *Inflam↓, *MitoP↑, *Aβ↓, *tau↓, *NLRP3↓, *SIRT1↑, *SIRT3↑,
4858- Uro,    The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent
- in-vitro, Nor, NA
*ROS?, *neuroP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *monoA↓, *tyrosinase↓,
618- VitC,    Low levels of catalase enzyme make cancer cells vulnerable to high-dose ascorbate
- in-vitro, Var, NA
Catalase↓,
619- VitC,    Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress
- in-vitro, BC, BT20
Catalase↝,
3110- VitC,    Vitamin C Attenuates Oxidative Stress, Inflammation, and Apoptosis Induced by Acute Hypoxia through the Nrf2/Keap1 Signaling Pathway in Gibel Carp (Carassius gibelio)
- in-vivo, Nor, NA
*IL2↑, *IL6↑, *IL12↑, *NRF2↑, *Catalase↑, *SOD↑, *GPx↑, *GRP78/BiP↓, *ER Stress↓,
3112- VitC,    Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
- Review, Nor, NA
*ROS↓, *antiOx↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *AP-1↑, *Inflam↓, *CRP↓, IFN-γ↓,
7921- VT,    Vitexin's Role in Colon Cancer Apoptosis: AMPK/mTOR Pathway Modulation Explored Through Experimental and Computational Approaches
- in-vitro, Colon, Caco-2
Dose↝, tumCV↓, SOD↓, Catalase↓, MDA↑, P53↑, BAX↓, TSC2↑, SESN2↑, PUMA↑, AMPK↑, PI3K↑, Akt↑, mTOR↓,

Showing Research Papers: 301 to 346 of 346
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 346

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 11,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 44,   Catalase↑, 34,   Catalase↝, 1,   Catalase∅, 2,   GCLM↑, 2,   GPx↓, 8,   GPx↑, 19,   GPx1⇅, 1,   GPx1∅, 1,   GPx4↓, 4,   GSH↓, 30,   GSH↑, 15,   GSH/GSSG↓, 2,   GSR↓, 1,   GSR↑, 4,   GSS↑, 1,   GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 4,   GSTs∅, 1,   H2O2↓, 3,   H2O2↑, 2,   HO-1↓, 6,   HO-1↑, 12,   Iron↑, 1,   i-Iron↑, 1,   lipid-P↓, 5,   lipid-P↑, 9,   MDA?, 1,   MDA↓, 8,   MDA↑, 12,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 3,   NRF2↓, 12,   NRF2↑, 18,   NRF2↝, 1,   Prx↓, 2,   PrxII↓, 1,   ROS↓, 27,   ROS↑, 97,   ROS⇅, 2,   ROS↝, 1,   i-ROS↑, 1,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 27,   SOD↑, 25,   SOD∅, 1,   SOD1↓, 2,   SOD1↑, 3,   SOD2↓, 7,   SOD2↑, 2,   T-SOD↓, 1,   TAC↓, 3,   TBARS↑, 1,   Thiols↓, 1,   TOS↑, 1,   Trx↓, 2,   Trx1↓, 1,   Trx1↑, 1,   TrxR↓, 1,   uricA↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 1,   CDC25↓, 4,   compI↓, 1,   compIII↓, 1,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 7,   OCR↑, 2,   OXPHOS↑, 4,   PGC-1α↑, 1,   PINK1↑, 1,   SIRT3↓, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 2,   ALAT↓, 3,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 5,   ATP↓, 7,   ATP↑, 2,   mt-ATP↓, 1,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   citrate↓, 1,   FAO↑, 1,   FASN↓, 3,   G6PD↓, 1,   GAPDH↓, 1,   GLO-I↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 12,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 4,   HK2↓, 4,   lactateProd↓, 4,   LDHA↓, 4,   LDL↓, 1,   MCT4↓, 1,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 2,   NADPH↑, 4,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PKM2↓, 3,   Pyruv↓, 1,   SCD1↓, 1,   SIRT1↓, 4,   SIRT1↑, 4,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 7,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 5,   Apoptosis↓, 5,   Apoptosis↑, 74,   ASC↓, 1,   BAD↓, 1,   BAD↑, 4,   Bak↓, 1,   Bak↑, 2,   BAX↓, 4,   BAX↑, 47,   Bax:Bcl2↑, 6,   Bcl-2↓, 48,   Bcl-2↑, 3,   Bcl-xL↓, 9,   Bcl-xL↑, 1,   BID↑, 2,   BIM↑, 1,   BNIP3↑, 1,   Casp↑, 10,   Casp↝, 1,   Casp1↓, 1,   Casp3↓, 2,   Casp3↑, 53,   cl‑Casp3↑, 7,   cl‑Casp3⇅, 1,   proCasp3↓, 1,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 17,   cl‑Casp8↑, 1,   Casp9↑, 37,   cl‑Casp9↑, 6,   proCasp9↓, 1,   cFLIP↓, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 26,   mt-Cyt‑c↓, 1,   Diablo↑, 1,   DR5↑, 6,   FADD↑, 1,   Fas↑, 10,   FasL↑, 2,   Ferroptosis↑, 1,   GSDMD↑, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 4,   iNOS↑, 1,   Mcl-1↓, 1,   MDM2↓, 3,   p‑MDM2↓, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 7,   p‑p38↑, 3,   pS2/TFF1↑, 1,   PUMA↑, 3,   survivin↓, 9,   TumCD↑, 9,   XIAP↓, 9,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 44,   Akt↑, 5,   p‑Akt↓, 12,   AMPKα↑, 1,   BRAF↑, 1,   BRAF↝, 1,   CK2↓, 2,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 9,   EGFR↑, 2,   p‑EGFR↓, 1,   ERK↓, 16,   ERK↑, 1,   p‑ERK↓, 4,   FGFR1↓, 2,   FGFR2↓, 1,   HER2/EBBR2↓, 3,   HGF/c-Met↓, 1,   IGF-1R↓, 3,   IKKα↓, 1,   JAK↓, 2,   JAK1↓, 1,   JAK2↓, 2,   JNK↓, 2,   JNK↑, 9,   p‑JNK↓, 1,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 9,   MAPK↑, 11,   MAPK↝, 2,   p‑MAPK↑, 1,   MARK4↓, 1,   p‑MEK↓, 2,   MKK4↓, 1,   mTOR↓, 25,   mTOR↝, 1,   p‑mTOR↓, 4,   P70S6K↓, 3,   p‑P70S6K↓, 1,   PI3K↓, 33,   PI3K↑, 3,   p‑PI3K↓, 2,   p‑PI3K↑, 1,   PI3K/Akt↓, 2,   PI3K/Akt↝, 1,   PKCδ↓, 3,   PTEN↓, 2,   PTEN↑, 5,   PTEN↝, 1,   Raf↓, 2,   RAS↓, 5,   RAS↑, 1,   Sp1/3/4↓, 4,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 24,   p‑STAT3↓, 6,   p‑STAT3↑, 1,   p‑STAT6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 3,   cJun↓, 1,   cMyc↓, 8,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 2,   EZH2↓, 2,   FOXM1↓, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 3,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   H3↓, 1,   H4↓, 1,   HATs↓, 1,   HDAC↓, 8,   HDAC1↓, 3,   HDAC2↓, 5,   HDAC3↓, 3,   miR-124-3p↓, 1,   miR-155↓, 1,   miR-21↓, 1,   miR-22↑, 1,   miR-25-5p↓, 1,   miR-34a↓, 1,   OCT4↓, 4,   other?, 1,   other↓, 5,   other↑, 7,   other↝, 1,   PAX2↓, 1,   PhotoS↑, 1,   SOX2↓, 1,   SOX9↓, 1,   TET3↑, 1,   tumCV?, 1,   tumCV↓, 19,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 5,   eIF2α↑, 3,   p‑eIF2α↑, 1,   ER Stress↑, 14,   GRP78/BiP↑, 2,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 5,   HSPs↑, 2,   NQO2↑, 1,   PERK↑, 1,   p‑PERK↑, 1,   UPR↑, 4,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 7,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 3,   MitoP↑, 1,   p62↓, 2,   PARK2↑, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 14,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↓, 2,   DNAdam↑, 22,   DNArepair↑, 1,   hTERT/TERT↓, 2,   P53↓, 2,   P53↑, 40,   P53↝, 1,   p‑P53↑, 1,   PARP↑, 8,   cl‑PARP↓, 1,   cl‑PARP↑, 16,   PCNA↓, 13,   SIRT6↓, 1,   Telomerase↓, 3,   TOP1↓, 3,   TOP2↓, 3,   γH2AX↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 1,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK2↓, 12,   CDK2↑, 2,   CDK4↓, 16,   CDK6↓, 3,   CDK6↑, 1,   CDKN1C/p57↑, 1,   CHK1↓, 1,   Chk2↓, 1,   Cyc↓, 3,   cycA1/CCNA1↓, 2,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 21,   cycE/CCNE↓, 4,   cycE/CCNE↑, 1,   E2Fs↓, 2,   GADD45A↑, 1,   Ki-67↓, 8,   mitA↑, 1,   P21↓, 2,   P21↑, 21,   p27/CDKN1B↑, 10,   pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 63,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 1,   CD34↓, 1,   cFos↑, 1,   CSCs↓, 5,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 2,   Gli1↓, 3,   HH↓, 1,   IGF-1↓, 6,   IGFBP3↑, 1,   Ki-67↓, 8,   mTORC1↓, 1,   Nanog↓, 2,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH1↓, 4,   NOTCH1↑, 1,   Shh↓, 2,   Smo↓, 1,   TumCG↓, 17,   TumCG↑, 2,   TumCP↓, 44,   tyrosinase↓, 1,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   ATPase↓, 1,   AXL↓, 2,   BACH1↓, 1,   Ca+2↓, 1,   Ca+2↑, 6,   Ca+2↝, 1,   i-Ca+2↑, 2,   cal2↓, 1,   CD11b↑, 1,   Cdc42↓, 1,   E-cadherin↓, 6,   E-cadherin↑, 12,   EMT↓, 19,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 2,   F-actin↓, 1,   FAK↓, 5,   p‑FAK↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   LAMs↓, 1,   LRP1↓, 1,   LRP1↑, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 2,   MMP13↓, 2,   MMP2↓, 23,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 28,   MMP9↑, 2,   MMPs↓, 10,   MTA1↓, 1,   N-cadherin↓, 11,   PDGF↓, 2,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 3,   Rho↝, 1,   ROCK1↓, 2,   Slug?, 1,   Slug↓, 1,   Smad1↓, 1,   Smad1↑, 1,   Snail?, 1,   Snail↓, 3,   TET1↑, 3,   TGF-β↓, 3,   TIMP1↑, 4,   TIMP2↓, 2,   TIMP2↑, 4,   TIMP3↑, 1,   TumCI↓, 21,   TumCMig↓, 21,   TumMeta↓, 21,   TumMeta↑, 2,   Twist↓, 6,   Tyro3↓, 1,   uPA↓, 2,   uPAR↓, 1,   Vim↓, 10,   Vim↑, 1,   Zeb1↓, 2,   ZEB2↓, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 27,   angioG↑, 1,   CD31/PECAM-1↓, 2,   HIF-1↓, 2,   Hif1a↓, 21,   Hif1a↑, 1,   NO↓, 4,   NO↑, 3,   VCAM-1↓, 1,   VEGF↓, 35,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB∅, 1,   CLDN1↓, 2,   GLUT1↓, 4,   GLUT1↑, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 2,   MMP↓, 39,   MMP↑, 2,   NHE1↓, 1,   TRPM7↓, 1,   TRPV1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 4,   CD47↓, 1,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 32,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCR4↓, 4,   DR4↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 4,   IFN-γ↓, 3,   IL1↓, 4,   IL1↑, 1,   IL10↑, 2,   IL1β↓, 6,   IL2↓, 2,   IL2↑, 3,   IL4↓, 2,   IL4↑, 2,   IL6↓, 22,   IL8↓, 6,   Imm↑, 3,   Imm↝, 1,   Inflam↓, 11,   Inflam↑, 1,   MCP1/CCL2↓, 4,   MCT1↓, 1,   MIP2↓, 1,   NF-kB↓, 42,   NF-kB↑, 2,   p‑NF-kB↑, 1,   NK cell↑, 6,   NLRP3↓, 2,   NLRP3↑, 2,   p65↓, 3,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 6,   PGE1↓, 1,   PGE2↓, 10,   PSA↓, 3,   PSA∅, 1,   RAGE↓, 1,   Resistin↓, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 3,   TNF-α↓, 20,   TNF-α↑, 3,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,   pH∅, 1,   e-pH↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   PRNP↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 6,   ERα/ESR1↓, 2,   Estro↝, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARγ↓, 1,   PPARγ↑, 3,   PPARγ↝, 1,   PR↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 12,   BioAv↑, 8,   BioAv↝, 5,   ChemoSen↑, 52,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A2↓, 1,   DDS↑, 1,   Dose↑, 2,   Dose↝, 22,   Dose∅, 3,   eff↓, 12,   eff↑, 29,   eff↝, 3,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↝, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   P-gp/ABCB1↑, 1,   P450↓, 2,   RadioS↑, 17,   selectivity↓, 1,   selectivity↑, 34,   Synergy↑, 38,   TET2↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 3,   AR↓, 6,   AST↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 1,   BRAF↑, 1,   BRAF↝, 1,   BRCA1↑, 1,   BUN↓, 1,   CEA↓, 2,   creat↓, 1,   CRP↓, 1,   EGFR↓, 9,   EGFR↑, 2,   p‑EGFR↓, 1,   ERα/ESR1↓, 2,   EZH2↓, 2,   FOXM1↓, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 2,   IL6↓, 22,   KRAS↓, 1,   LDH↓, 2,   LDH↝, 1,   NSE↓, 1,   PD-L1↓, 6,   PSA↓, 3,   PSA∅, 1,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 28,   antiNeop↑, 1,   AntiTum↑, 5,   Appetite↑, 1,   BowelM↑, 1,   cachexia↓, 2,   cardioP↑, 10,   chemoP↑, 19,   chemoPv↑, 5,   ChemoSideEff↓, 1,   cognitive↑, 3,   fatigue↓, 1,   hepatoP↑, 10,   Mucositis↓, 1,   neuroP↑, 5,   NP/CIPN↓, 2,   OS↑, 9,   Pain↓, 3,   PFS↑, 1,   Pin1↓, 1,   QoL↑, 6,   radioP↑, 10,   RenoP↑, 5,   Risk↓, 6,   Sleep↑, 2,   toxicity↓, 4,   toxicity↝, 2,   TumVol↓, 12,   TumW↓, 2,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 3,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,  
Total Targets: 671

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx?, 2,   antiOx↓, 2,   antiOx↑, 128,   ARE↑, 5,   Bil↓, 1,   Bil↑, 1,   Catalase↓, 9,   Catalase↑, 265,   Catalase↝, 2,   Copper↓, 1,   Fenton↓, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx↓, 5,   GPx↑, 120,   GPx↝, 1,   GPx1↑, 5,   GPx3↑, 1,   GPx4↓, 1,   GPx4↑, 5,   GSH↓, 4,   GSH↑, 131,   GSH∅, 1,   GSH/GSSG↓, 1,   GSH/GSSG↑, 1,   GSR↓, 1,   GSR↑, 25,   GSTs↓, 1,   GSTs↑, 36,   H2O2↓, 11,   HDL↓, 1,   HDL↑, 5,   HO-1↓, 3,   HO-1↑, 74,   HO-1⇅, 1,   Iron↓, 2,   i-Iron↓, 1,   i-Iron↑, 1,   Keap1↓, 5,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 88,   MDA↓, 108,   MDA↑, 4,   MPO↓, 6,   MPO↑, 1,   NADH↓, 1,   NOX↓, 3,   NOX4↓, 3,   NQO1↑, 15,   Nrf1↑, 2,   NRF2↓, 4,   NRF2↑, 112,   Prx↑, 4,   RNS↓, 5,   ROMO1↑, 1,   ROS?, 2,   ROS↓, 220,   ROS↑, 4,   ROS⇅, 1,   ROS∅, 2,   mt-ROS?, 1,   mt-ROS↓, 3,   SAM-e↑, 1,   SOD?, 2,   SOD↓, 7,   SOD↑, 220,   SOD↝, 2,   SOD1↑, 9,   SOD2↑, 7,   TAC↑, 18,   TBARS↓, 5,   TBARS↑, 1,   Thiols↑, 3,   TOS↓, 1,   Trx↓, 1,   Trx↑, 3,   Trx1↑, 3,   uricA↓, 3,   VitC↑, 4,   VitE↓, 1,   VitE↑, 3,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 8,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   EGF↓, 1,   ETC↑, 1,   HSP60/HSPD1↓, 1,   Insulin↑, 3,   MFN1↑, 1,   MFN2↑, 1,   mtDam↓, 7,   NGB↑, 1,   OCR↑, 1,   OPA1↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 3,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 6,   ACC↓, 1,   ACC↑, 1,   mt-ACC⇅, 1,   ACSL4↓, 1,   ALAT↓, 35,   ALAT↑, 1,   ALAT∅, 1,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 9,   ATP↑, 13,   ATP↝, 1,   Buty↑, 1,   cAMP↑, 1,   CRM↑, 1,   cytoP450↓, 1,   DGAT1↓, 1,   FAO↑, 1,   FASN↓, 2,   G6PD↑, 1,   GAPDH↑, 1,   glucose↓, 6,   glucose↝, 2,   GlucoseCon↓, 1,   GlucoseCon↑, 3,   Glycolysis↝, 1,   GSK‐3β↓, 12,   GSK‐3β↑, 1,   H2S↑, 2,   HK2↓, 1,   HK2↑, 1,   HMG-CoA↓, 2,   IDH1↑, 1,   LDL↓, 14,   NAD↑, 2,   NAD↝, 1,   NADPH↓, 8,   NADPH↑, 7,   NADPH∅, 1,   PDKs↑, 1,   PFK↓, 1,   PGC1A↑, 1,   PKM1↑, 1,   PKM2↓, 1,   PKM2↑, 1,   PLA2↓, 1,   SCFAs↑, 1,   SIRT1↑, 15,   SREBP1/SREBF1↓, 1,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 22,   ASC↓, 1,   ASK1↓, 1,   BAD↓, 1,   BAX↓, 19,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-2↑, 16,   Bcl-2↝, 1,   Bcl-xL↑, 1,   Casp↓, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 28,   Casp3↑, 1,   cl‑Casp3↓, 1,   Casp8↓, 1,   Casp9↓, 9,   Cyt‑c↓, 4,   Fas↓, 1,   Ferroptosis↓, 5,   GranB/GZMB↓, 1,   iNOS↓, 32,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 6,   p38↑, 1,   p‑p38↓, 1,   survivin↓, 1,   TUNEL↓, 1,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 14,   p‑Akt↓, 1,   p‑Akt↑, 3,   CREB↑, 1,   p‑CREB↑, 3,   ERK↓, 6,   ERK↑, 4,   p‑ERK↓, 2,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   Hippo↑, 1,   IKKα↓, 1,   IKKα↑, 1,   IκB?, 1,   JAK2↓, 2,   JAK2↑, 1,   p‑JAK2↓, 1,   JNK↓, 9,   JNK↑, 1,   p‑JNK↓, 5,   MAPK↓, 12,   MAPK↑, 2,   MAPK↝, 1,   p‑MAPK↓, 1,   mTOR↓, 4,   mTOR↑, 6,   p‑mTOR↓, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PFKFB2↓, 1,   PI3K↓, 4,   PI3K↑, 13,   p‑PI3K↓, 1,   PKCδ↑, 1,   PP2A↑, 1,   PTEN↓, 1,   PTEN↑, 2,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 4,   STAT3↑, 2,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF4↓, 2,   cJun↓, 1,   cMyc↓, 1,   FOXO1↝, 1,   FOXO3?, 1,   FOXO3↑, 3,   HDAC↓, 1,   miR-34a↓, 1,   other↓, 6,   other↑, 14,   other↝, 5,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 4,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 7,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 5,   HSPs↑, 1,   PERK↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↓, 1,   p62↑, 4,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 14,   P53↓, 2,   PARP↓, 1,   PARP1↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   cycD1/CCND1↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↑, 1,   Diff↝, 1,   IGF-1↑, 1,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 1,   NOTCH1↑, 1,   TumCP↓, 2,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AP-1↓, 3,   AP-1↑, 1,   BACH1↓, 1,   Ca+2↓, 10,   Ca+2↑, 1,   Ca+2↝, 1,   i-Ca+2↓, 1,   Cartilage↑, 2,   COL1↓, 2,   COL1↑, 2,   E-cadherin↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   LRP1↑, 1,   MMP13↓, 2,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 7,   MMPs↓, 5,   MUC1↑, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   ROCK1↓, 1,   serineP↓, 1,   TGF-β↓, 5,   TGF-β↑, 3,   TGF-β1↓, 2,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 2,   TXNIP↑, 1,   Vim↓, 2,   α-SMA↓, 6,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 1,   eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 2,   LOX1↓, 2,   NO↓, 33,   NO↑, 6,   TXA2↓, 1,   VCAM-1↓, 5,   VEGF↓, 4,   VEGF↑, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 2,   BBB↑, 19,   BBB↝, 1,   CLDN1↓, 1,   GastroP↑, 5,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 6,   MMP↓, 2,   MMP↑, 24,   OCLN↓, 1,   TJ↑, 2,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 3,   TRPM7⇅, 1,   TRPV3↑, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 4,   CD8+↑, 1,   COX1↓, 5,   COX2/PTGS2↓, 58,   COX2/PTGS2↑, 2,   CXCc↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 6,   IFN-γ↓, 5,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 10,   IL10↑, 14,   IL12↓, 4,   IL12↑, 1,   IL17↓, 3,   IL18↓, 1,   IL1β↓, 70,   IL1β↑, 1,   IL2↓, 4,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL4↓, 8,   IL4↑, 4,   IL5↓, 2,   IL6↓, 64,   IL6↑, 5,   IL8↓, 7,   IL8↑, 1,   Imm↑, 10,   INF-γ↓, 2,   Inflam↓, 148,   Inflam↑, 2,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 2,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 8,   MyD88↓, 2,   NeuroI↓, 4,   NF-kB↓, 78,   NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 15,   NLRP3↑, 1,   p65↓, 1,   PGE2↓, 19,   PGE2↑, 3,   RAGE↓, 4,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 19,   TNF-α↓, 95,   TNF-α↑, 2,   Treg lymp↝, 1,   TRIF↓, 2,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 6,   Ach↑, 5,   AChE↓, 40,   AChE↑, 1,   ADAM10↑, 2,   BChE↓, 8,   BDNF↑, 26,   BDNF∅, 1,   ChAT↑, 5,   EndoR↑, 1,   GABA↓, 2,   GABA↑, 3,   MAOA↓, 5,   MAOB↓, 1,   monoA↓, 1,   monoA↑, 1,   NGF↑, 5,   PSD95↑, 2,   RELN↑, 1,   SNAP25↑, 2,   TPH1↓, 1,   TrkB↑, 4,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 5,   APP↓, 6,   Aβ↓, 42,   Aβ42↓, 3,   BACE/β-secretase↓, 10,   PSEN1/PS1↓, 1,   tau↓, 8,   p‑tau↓, 10,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   BNP↓, 1,   cortisol↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   GLP-1R↑, 1,   GR↓, 1,   GR↑, 4,   GR↝, 1,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 5,   testos↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 22,   BioAv↑, 50,   BioAv⇅, 1,   BioAv↝, 21,   BioEnh↑, 3,   ChemoSen↑, 1,   CompStab↑, 3,   CYP2D6↓, 1,   CYP2E1↓, 2,   CYP3A2↓, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose↝, 29,   eff↑, 21,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 6,   Half-Life↓, 1,   Half-Life↑, 2,   Half-Life↝, 8,   P-gp/ABCB1↓, 2,   P450↓, 2,   P450↑, 2,   selectivity↑, 1,   Synergy↑, 17,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 35,   ALAT↑, 1,   ALAT∅, 1,   ALP↓, 14,   AST↓, 37,   AST↑, 1,   AST∅, 1,   BG↓, 4,   Bil↓, 1,   Bil↑, 1,   BloodF↑, 2,   BMD↑, 3,   BP↓, 11,   BP∅, 1,   BUN?, 1,   BUN↓, 5,   Calcium↑, 1,   creat↓, 10,   CRP↓, 7,   hs-CRP↓, 1,   IL6↓, 64,   IL6↑, 5,   LDH↓, 12,   LDH↑, 2,   Mag↑, 1,   NOS2↓, 2,   RAGE↓, 4,   SpO2↑, 1,   TG/TAG↓, 2,   Urea↓, 4,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 5,   antiAll?, 1,   antiAll↑, 17,   AntiArt↑, 8,   AntiCan↑, 18,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 25,   antiM↑, 1,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 3,   antiPy↑, 1,   AntiTum↑, 1,   ANXi↓, 1,   cardioP?, 1,   cardioP↑, 54,   CardioT↓, 1,   chemoP↑, 11,   chemoPv↑, 2,   ChemoSideEff↓, 1,   cognitive↓, 2,   cognitive↑, 53,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 58,   Learn↑, 6,   memory↑, 50,   Mood↑, 1,   motorD↓, 1,   motorD↑, 10,   Mucositis↓, 2,   neuroP?, 1,   neuroP↑, 110,   NP/CIPN↓, 1,   Obesity↓, 10,   OS↑, 2,   Pain↓, 7,   QoL↑, 2,   radioP↑, 8,   RenoP↓, 1,   RenoP↑, 26,   Risk↓, 3,   Sleep↑, 3,   Strength↑, 3,   Stroke↓, 9,   toxicity?, 2,   toxicity↓, 23,   toxicity↑, 4,   toxicity↝, 6,   toxicity∅, 5,   Weight↓, 2,   Weight↑, 1,   Wound Healing↓, 1,   Wound Healing↑, 9,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiBio↑, 12,   AntiFungal↑, 4,   AntiP↑, 2,   AntiViral↑, 8,   Bacteria↓, 17,   Diar↓, 3,   GutMicro↑, 26,   Inf↓, 1,   Sepsis↓, 9,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 1,   Ingr↝, 4,   Phen↑, 1,   QC↑, 1,  
Total Targets: 602

Scientific Paper Hit Count for: Catalase, Catalase
18 Thymoquinone
13 Magnetic Fields
13 Curcumin
12 Hydrogen Gas
11 Luteolin
10 Silver-NanoParticles
10 Lycopene
9 Melatonin
9 Quercetin
8 Resveratrol
8 Carvacrol
8 Ferulic acid
7 Boron
7 Chrysin
7 Silymarin (Milk Thistle) silibinin
6 Selenium NanoParticles
6 Moringa oleifera
6 Rosmarinic acid
5 Apigenin (mainly Parsley)
5 Propolis -bee glue
5 Crocetin
5 EGCG (Epigallocatechin Gallate)
5 Hyperoside
4 Alpha-Lipoic-Acid
4 Radiotherapy/Radiation
4 Betulinic acid
4 Chlorogenic acid
4 Chemotherapy
4 Eugenol
4 Gallic acid
4 Morin
4 Sulforaphane (mainly Broccoli)
4 Urolithin
4 Vitamin C (Ascorbic Acid)
3 Ascorbyl Palmitate
3 Capsaicin
3 doxorubicin
3 D-limonene
3 Fisetin
3 Isoliquiritigenin
3 Licorice
3 Pterostilbene
3 Shikonin
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Artemisinin
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Berberine
2 Selenium
2 Boswellia (frankincense)
2 α-Bisabolol / Chamomile oil
2 buckwheat sprouts
2 Thymol-Thymus vulgaris
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Carvone
2 Copper and Cu NanoParticles
2 Date Fruit Extract
2 Sesame seeds and Oil
2 Shilajit/Fulvic Acid
2 Cisplatin
2 Graviola
2 HydroxyCitric Acid
2 Hibiscus sabdariffa
2 Honokiol
2 isoquercitrin
2 Kaempferol
2 Magnolol
2 Matrine
2 Magnetic Field Rotating
2 Methylsulfonylmethane
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Piperine
2 Piperlongumine
2 salinomycin
2 Selenite (Sodium)
1 1,8-Cineole
1 5-Aminolevulinic acid
1 Annona atemoya Seed Extract
1 Photodynamic Therapy
1 Allicin (mainly Garlic)
1 Andrographis
1 Astaxanthin
1 Aloe anthraquinones
1 Beta-Caryophyllene
1 Bacopa monnieri
1 Bromelain
1 Caffeic acid
1 chaetocin
1 Ginkgo biloba-EGb 761
1 Emodin
1 Exercise
1 Formononetin
1 Fucoidan
1 Germanium inorganic
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Zinc
1 Germacranolide sesquiterpene lactone
1 Orlistat
1 Hydroxycinnamic-acid
1 Isobavachalcone
1 Inositol
1 Butein
1 Scopoletin
1 isoorientin
1 Ivermectin
1 Juglone
1 Linalool
1 Mung Bean Sprouts
1 Methyl Jasmonate
1 Metformin
1 Magnesium
1 Lemon Balm/Melissa officinalis
1 Oleuropein
1 HydroxyTyrosol
1 Propyl gallate
1 Parthenolide
1 Oxygen, Hyperbaric
1 Taurine
1 5-fluorouracil
1 Turmerones
1 Ursolic acid
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:46  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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