MDA Cancer Research Results

MDA, Serum malondialdehyde: Click to Expand ⟱
Source:
Type:
MDA : malondialdehyde. The level of oxidative stress can be measured by assessing the MDA levels.
Since MDA is highly cytotoxic and carcinogenic agent it is frequently used as a biomarker of oxidative stress during major health problems such as cancer, etc.
Malondialdehyde (MDA) is the most widely used agent to estimate the extent of lipid peroxidation. Timely diagnosis of the condition followed by supplementation with antioxidants like beta-carotene, pro-vitamin A, vitamin A, vitamin C, vitamin E, lipoic acid, zinc, selenium, and spirulina can prevent potentially malignant disorders.
MDA is a lipid peroxidation marker
Scientific Papers found: Click to Expand⟱
3014- RosA,    Rosmarinic Acid Supplementation Acts as an Effective Antioxidant for Restoring the Antioxidation/Oxidation Balance in Wistar Rats with Cadmium-Induced Toxicity
- in-vivo, Nor, NA
*antiOx↑, *Thiols↑, *GSH↑, *TAC↑, *SOD↑, *GPx↑, *Catalase↑, *ALP↓, *ALAT↓, *AST↓, *creat↓, *BUN↓, *H2O2↓, *MDA↓, *ROS↓, cardioP↑, hepatoP↑, neuroP↑, *antiAll↑,
3007- RosA,    Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action
- Review, Nor, NA
*ROS↓, *lipid-P↓, *Inflam↓, *neuroP↑, *angioG↓, *Synergy↑, *AST↓, *ALAT↓, *GSSG↓, *eNOS↓, *iNOS↓, *NO↓, *NF-kB↓, *MMP2↓, *MDA↓, *TNF-α↓, *GSH↑, *SOD↑, *IL6↓, *PGE2↓, *COX2/PTGS2↓, *mTOR↑,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
1251- RT,  OLST,    Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions
- in-vitro, BC, MCF7 - in-vitro, PC, PANC1 - in-vivo, NA, NA
TumVol↓, *CEA↓, *FASN↓, *ROS↓, *MDA↓, *GSH↑, Apoptosis↑,
3936- RT,    Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation
- in-vivo, AD, NA
*memory↑, *Aβ↓, *SOD↑, *GSH↑, *GSSG↓, *MDA↓, *IL1β↓, *IL6↓, *antiOx↑, *Inflam↓,
3934- RT,    Rutin: A Potential Therapeutic Agent for Alzheimer Disease
- Review, AD, NA
*ROS↓, *Aβ↓, *neuroP↑, *memory↑, *GSH↑, *SOD↑, *lipid-P↓, *MDA↓, *IL1β↓, *IL6↓, *cognitive↑, *BBB↑, *MAPK↑, *IL8↓, *COX2/PTGS2↓, *NF-kB↓, *iNOS↓,
323- Sal,  AgNPs,    Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy
- in-vitro, BC, MDA-MB-231 - in-vitro, Ovarian, A2780S
TumCD↑, LDH↓, MDA↑, SOD↓, ROS↑, GSH↓, Catalase↓, MMP↓, P53↑, P21↑, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Apoptosis↑, TumAuto↑,
5139- SAS,    Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis
- in-vitro, OS, MG63 - in-vitro, OS, U2OS
*Inflam↓, TumCP↓, TumCMig↓, Apoptosis↑, Ferroptosis↑, Iron↑, MDA↑, ROS↑, GSH↓, SOD↓, MMP↓, NRF2↓, xCT/SLC7A11↓, GPx4↓, FTH1↓,
4749- Se,  Chemo,  antiOx,    Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy
- Trial, Ovarian, NA
*GSH↑, *MDA↑, *other?, *other?, *chemoP↑,
4735- SeNPs,    Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum
- in-vivo, Nor, NA
*MDA↓, *H2O2↓, *Catalase↑, *SOD↑, *GSTs↑, *GSH↑, *NRF2↓, *ATG3↓, *AMPK↓, *ROS↓,
4445- SeNPs,  DFE,    A comparative study on the hepatoprotective effect of selenium-nanoparticles and dates flesh extract on carbon tetrachloride induced liver damage in albino rats
- in-vivo, LiverDam, NA
*hepatoP↑, *antiOx↑, *AntiCan↑, *BioAv↑, *toxicity↓, *ROS↓, *MDA↓, *ALAT↓, *ALB↑, *GSH↑, *SOD↑, *RenoP↑,
9281- SES, SSM,  LIGs,    A comprehensive review on the anti-cancer properties of sesame lignans: chemical composition, molecular mechanisms and prospects
- Review, Var, NA
Ingr↝, ChemoSen↑, *Sleep↑, *antiOx↑, *GPx↑, *GSR↑, *GSH↑, *MDA↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK2↓, P53↑, COX2/PTGS2↓, TumCP↓, Apoptosis↑, DNAdam↑, cl‑Casp3↑, NF-kB↓, ROS↑, MMP↓, VEGF↓, MMP9↓, Hif1a↓,
4190- Sesame,    Sesame Seeds: A Nutrient-Rich Superfood
- Review, Nor, NA
*antiOx↑, *LDL↓, *Aβ↓, *TNF-α↓, *SOD↑, *SIRT1↑, *Catalase↑, *GSH↑, *MDA↓, *GSTs↑, *IL4↑, *GPx↑, *COX2/PTGS2↓, *PGE2↓, *NO↓, CDK2↑, COX2/PTGS2↑, MMP9↑, ICAM-1↓, *BDNF↑, *PPARγ↑, *AChE↓, *Inflam↓, *HO-1↑, *NF-kB↓, *ROS↓,
3659- SFN,    Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease
- in-vitro, AD, NA
*NRF2↑, *ROS↓, *MDA↓, *SOD↑, *IL1β↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *Inflam↓,
3658- SFN,    Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer’s Disease
- Review, AD, NA
*NRF2↑, *antiOx↑, *neuroP↑, *Aβ↓, *BACE/β-secretase↓, *NQO1↑, *IL1β↓, *TNF-α↓, *IL6↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *NLRP3↓, *Ca+2↓, *GSH↑, *MDA↓, *ROS↓, *SOD↑, *HO-1↑, *TrxR↑, *cognitive↑, *tau↓, *HSP70/HSPA5↑,
1483- SFN,    Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment
- in-vitro, OS, 143B - in-vitro, Nor, HEK293 - in-vivo, OS, NA
AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,
1479- SFN,    Sulforaphane triggers Sirtuin 3-mediated ferroptosis in colorectal cancer cells via activating the adenosine 5'-monophosphate (AMP)-activated protein kinase/ mechanistic target of rapamycin signaling pathway
- in-vitro, CRC, HCT116
Ferroptosis↑, SIRT3↑, AMPK↑, mTOR↑, tumCV↓, ROS↑, MDA↑, Iron↑,
3948- Shank,    Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain
- in-vivo, AD, NA
*AChE↓, *ChAT↑, *NGF↑, *CDK5↓, *neuroP↑, *MDA↓,
3307- SIL,    Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications
- Review, Var, NA
*NRF2↑, *antiOx↑, *chemoP↑, *Inflam↓, *BioAv↑, Synergy↑, *NQO1↑, TNF-α↓, IL6↓, *GSH↑, *ROS↓, *MDA↓, Synergy↑, *hepatoP↑, *GPx↑, *SOD↑, *Catalase↑, *HO-1↑, *neuroP↑,
3310- SIL,    Silymarin attenuates paraquat-induced lung injury via Nrf2-mediated pathway in vivo and in vitro
- in-vitro, Lung, A549
Inflam↓, MPO↓, NO↓, iNOS↓, ROS↓, MDA↑, SOD↑, Catalase↑, GPx↑, NRF2↑, HO-1↑, NADPH↑,
3311- SIL,    Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells
- in-vitro, Nor, PC12
*antiOx↑, *Inflam↓, AntiCan↑, *ROS↓, *MDA↓, *GSH↓, *NRF2↑, *GPx↑, *GCLC↑, *GCLM↑,
3313- SIL,    Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats
- in-vivo, Nor, NA
*NRF2↑, *HO-1↑, *creat↓, *BUN↓, *RenoP↑, *MDA↓, *TNF-α↓, *IL1β↓, *Cyt‑c↓, *Casp3↓, *GSTs↓, *GSH↑, *GPx4↑, *SOD↑, *GSR↓, *Ferroptosis↓,
4205- SIL,    The Therapeutic Effect of Silymarin and Silibinin on Depression and Anxiety Disorders and Possible Mechanism in the Brain: A Systematic Review
- Review, AD, NA
*BDNF↑, *5HT↑, *MDA↓, *GSH↑, *SOD↑, *Catalase↑, *IL6↓, *IL1β↓,
3318- SIL,    Pharmaceutical prospects of Silymarin for the treatment of neurological patients: an updated insight
- Review, AD, NA - Review, Park, NA
*hepatoP↑, *neuroP↑, *TLR4↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *memory↑, *cognitive↑, *NRF2↑, *HO-1↑, *ROS↓, *Akt↑, *mTOR↑, *SOD↑, *Catalase↑, *GSH↑, *IL10↑, *IL6↑, *NO↓, *MDA↓, *AChE↓, *MAPK↓, *BDNF↑,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2/PTGS2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,
3329- SIL,    Silymarin regulates the HIF-1 and iNOS expression in the brain and Gills of the hypoxic-reoxygenated rainbow trout (Oncorhynchus mykis)
- in-vivo, Nor, NA
*NO↓, *MDA↓, *TAC↑, *Hif1a↓, *iNOS↓,
3325- SIL,    Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury
- in-vivo, Nor, NA
*Inflam↓, *ROS↓, *Casp3↑, *Casp9↑, *Hif1a↓, *iNOS↓, *SOD↑, *MDA↓,
3653- SIL,    Silibinin ameliorates Aβ25-35-induced memory deficits in rats by modulating autophagy and attenuating neuroinflammation as well as oxidative stress
- in-vivo, AD, NA
*hepatoP↑, *neuroP↑, *cognitive↑, *memory↑, *Inflam↓, *GSH↑, *MDA↓, *Inflam↓, *antiOx↓,
4126- Silicon,  H2,    Oral Administration of Si-Based Agent Attenuates Oxidative Stress and Ischemia-Reperfusion Injury in a Rat Model: A Novel Hydrogen Administration Method
- in-vivo, Nor, NA
*creat↓, *ROS↓, *other↑, *MDA↓, *other↑, *Inflam↓,
2199- SK,    Induction of Ferroptosis by Shikonin in Gastric Cancer via the DLEU1/mTOR/GPX4 Axis
- in-vitro, GC, NA
ROS↑, lipid-P↑, Iron↑, MDA↑, GPx4↓, Ferritin↓, DLEU1↓, mTOR↓, Ferroptosis↑,
2198- SK,    Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis
- in-vitro, OS, MG63 - in-vitro, OS, 143B
TumCP↓, TumCCA↑, Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, mtDam↑, NRF2↓, xCT/SLC7A11↓, GPx4↓, GSH/GSSG↓, Keap1↑,
2220- SK,    Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *SIRT1↓, *NRF2↑, *HO-1↑, *GSH↑, *TAC↑, *SOD↑, *MDA↓, *NO↓, *iNOS↓, *NHE3↑, *PI3K↑,
2214- SK,    Shikonin Attenuates Cochlear Spiral Ganglion Neuron Degeneration by Activating Nrf2-ARE Signaling Pathway
- in-vitro, Nor, NA
*NRF2↑, *HO-1↑, *NQO1↑, *antiOx↑, *neuroP↑, *ROS↓, *MDA↓, *SOD↑, GSH↑,
1284- SK,    Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy
- in-vitro, Melanoma, RPMI-8226 - in-vitro, Melanoma, U266
Ferroptosis↑, LDH↓, ROS↑, Iron↑, lipid-P↑, ATP↓, HMGB1↓, GPx4↓, MDA↑, SOD↓, GSH↓,
9033- SP,    Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,
9043- SP,    Spirulina inhibits hepatocellular carcinoma through activating p53 and apoptosis and suppressing oxidative stress and angiogenesis
- in-vivo, HCC, NA
Dose↝, OS↑, AFP↓, TAC↑, BAX↑, P53↑, MDA↓, VEGF↓, ROS↓, angioG↓,
4498- SSE,    Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
*Imm↑, *GutMicro↑, *BioAv↑, *Risk↓, *Dose↝, Risk↓, *CRP↓, *GPx↓, *Inflam↓, *selenoP↑, *Dose↝, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *IL1↓, *MCP1/CCL2↓, *IL6↓, *TNF-α↓, Risk↓, *neuroP↑, *memory↑,
4723- SSE,    Selenium Induces Ferroptosis in Colorectal Cancer Cells via Direct Interaction with Nrf2 and Gpx4
- in-vitro, CRC, HCT116
TumCP↓, Iron↑, MDA↑, ROS↑, MMP↓, NRF2↓, GPx4↓, Ferroptosis↑,
4731- SSE,    Dietary selenium mitigates cadmium-induced apoptosis and inflammation in chicken testicles by inhibiting oxidative stress through the activation of the Nrf2/HO-1 signaling pathway
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *H2O2↓, *Catalase↑, *GSH↑, *NRF2↑, *HO-1↑, *Bcl-2↑, *other↝,
4215- SY,    Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathway
- in-vivo, AD, NA
*memory↑, *AChE↓, *ChAT↑, *SOD↓, *MDA↓, *GPx↑, *BDNF↑, *TrkB↑, *CREB↑, *ROS↓,
3960- Taur,    Versatile Triad Alliance: Bile Acid, Taurine and Microbiota
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *Inflam↓, *GABA↑, *memory↑, *cognitive↑, *iNOS↓, *CRP↓, *HO-1↑, *Prx↑, *Trx↑, *NRF2↑, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *MDA↓, *eff↝, *GutMicro↑, other↑,
1928- TQ,    Thymoquinone Crosstalks with DR5 to Sensitize TRAIL Resistance and Stimulate ROS-Mediated Cancer Apoptosis
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCP↓, DR4↑, DR5↑, Casp8↑, FADD↑, Bcl-2↓, ROS↑, NO↑, MDA↑,
2115- TQ,    Protective effects of Nigella sativa on gamma radiation-induced jejunal mucosal damage in rats
- in-vivo, Nor, NA
*radioP↑, *MDA↓, *GSH↑,
2124- TQ,    Thymoquinone: an emerging natural drug with a wide range of medical applications
- Review, Var, NA
hepatoP↑, Bax:Bcl2↑, cycD1/CCND1↓, P21↑, TRAIL↑, P53↑, TumCCA↑, hepatoP↑, *ALAT↓, *AST↓, *MDA↓, *GSSG↓, *COX2/PTGS2↓, *lipid-P↓, PPARγ↑, p38↑, ROS↑, ChemoSen↑, selectivity↑, selectivity↑, *MDA↓, *SOD↑, *antiAll↑,
2134- TQ,    Modulation of Nrf2/HO1 Pathway by Thymoquinone to Exert Protection Against Diazinon-induced Myocardial Infarction in Rats
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *MDA↓, *ROS↓, *GSSG↓, *GSH↑, *VitE↑, *VitC↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *cardioP↑, *GSH/GSSG↑, *GPx↑,
2092- TQ,    Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease
- Review, AD, NA
*iNOS↓, *ROS↓, *GSH↑, *neuroP↑, *MMPs↓, *MMP↑, *TXNIP↓, *Prx↑, *memory↑, *MDA↓, *SOD↑, *Catalase↑, *BioAv↑,
3409- TQ,    Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives
- in-vivo, Nor, NA
*MDA↓, *TGF-β↓, *CRP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *Casp3↓, *GSH↑, *NRF2↑, *IL10↑, *neuroP↑, *ROS↓, *Apoptosis↓, *Inflam↓,
3406- TQ,  SeNPs,    A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s disease
- in-vivo, AD, NA
*NRF2↑, *GSH↑, *MDA↓, *TNF-α↓,
3404- TQ,    The Neuroprotective Effects of Thymoquinone: A Review
- Review, Var, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *TNF-α↓, *IL6↓, *IL1β↓, *NF-kB↓, *iNOS↓, *NRF2↑, *neuroP↑, *MMP↑, *ROS↓, *MDA↓, *GSH↑, *Catalase↑, *SOD↑, *IL12↓, *MCP1/CCL2↓, *IP-10/CXCL-10↓, *PGE2↓, *antiAll?,
3398- TQ,  5-FU,    Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo
- in-vivo, Nor, NA
*RenoP↑, *TAC↑, *ROS↓, *lipid-P↓, *p38↓, *MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *MDA↓, *GPx↑, *GSR↑, *Catalase↑, *BUN↓, *LDH↓, *IL1β↓,

Showing Research Papers: 301 to 350 of 363
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 363

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 2,   Catalase↓, 11,   Catalase↑, 12,   Fenton↑, 2,   GCLM↓, 1,   GPx↓, 3,   GPx↑, 7,   GPx4↓, 30,   GPx4↑, 1,   GSH↓, 50,   GSH↑, 10,   GSH/GSSG↓, 2,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 3,   HO-1↓, 6,   HO-1↑, 11,   Iron↑, 25,   Iron↝, 1,   i-Iron↑, 3,   Keap1↑, 3,   lipid-P↓, 3,   lipid-P↑, 23,   MDA?, 1,   MDA↓, 23,   MDA↑, 63,   i-MDA↑, 4,   MPO↓, 2,   NADH↓, 1,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 2,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 14,   NRF2↑, 11,   OSI↑, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 14,   ROS↑, 94,   ROS⇅, 1,   ROS↝, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 14,   SOD↑, 17,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   T-SOD↓, 1,   TAC↓, 2,   TAC↑, 1,   TBARS↓, 1,   TOS↑, 2,   TrxR↓, 2,   uricA↓, 1,   xCT/SLC7A11↓, 8,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FTH1↓, 6,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 1,   NCOA4↑, 3,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   compI↓, 1,   compII↓, 1,   compIV↓, 1,   EGF↓, 1,   ETC↓, 2,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mtDam↑, 11,   OXPHOS↓, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SDH↓, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACSL4↑, 3,   ALAT↓, 4,   AMPK↓, 1,   AMPK↑, 8,   p‑AMPK↑, 2,   ATP↓, 7,   mt-ATP↓, 1,   citrate↓, 1,   FASN↓, 3,   G6PD↓, 2,   GAPDH↓, 1,   GLS↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 9,   GSK‐3β↓, 1,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 2,   HK2↓, 6,   lactateProd↓, 4,   lactateProd↑, 1,   LDHA↓, 3,   NAD↝, 1,   NADPH↑, 1,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PFKP↓, 1,   PKM2↓, 2,   PKM2↑, 1,   Pyruv↓, 1,   SCD1↓, 2,   SIRT1↓, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 2,   Apoptosis↓, 3,   Apoptosis↑, 56,   mt-Apoptosis↑, 1,   BAD↑, 1,   Bak↓, 1,   Bak↑, 2,   BAX↓, 1,   BAX↑, 34,   Bax:Bcl2↑, 10,   Bcl-2↓, 36,   Bcl-xL↓, 3,   BID↑, 3,   BIM↑, 1,   Casp↑, 5,   cl‑Casp↑, 1,   Casp12↑, 1,   Casp3↓, 2,   Casp3↑, 46,   cl‑Casp3↑, 6,   cl‑Casp3⇅, 1,   proCasp3↓, 1,   Casp7↑, 7,   Casp8↑, 14,   Casp9↑, 25,   cl‑Casp9↑, 2,   CellShr↑, 1,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 22,   mt-Cyt‑c↓, 1,   DR5↓, 1,   DR5↑, 5,   Endon↑, 1,   FADD↑, 3,   Fas↑, 5,   FasL↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 35,   GranB/GZMB↝, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   iNOS↓, 4,   Mcl-1↓, 1,   MDM2↓, 2,   MOMP↑, 2,   necrosis↑, 2,   p38↑, 5,   Perforin↝, 1,   pS2/TFF1↓, 1,   PUMA↑, 1,   Pyro↑, 2,   survivin↓, 6,   TNFR 1↑, 1,   TRAIL↑, 1,   TumCD↑, 6,   XIAP↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 37,   Akt↑, 4,   p‑Akt↓, 6,   AMPKα↑, 1,   BRAF↑, 1,   BRAF↝, 1,   CaMKII ↓, 1,   cMET↓, 2,   cSrc↓, 1,   EGFR↓, 5,   EGFR↑, 1,   ERK↓, 9,   ERK↑, 3,   p‑ERK↓, 1,   ERK5↓, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   IGF-1R↓, 2,   IKKα↓, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 5,   JNK↓, 1,   JNK↑, 4,   p‑JNK↑, 1,   LIMK1↓, 1,   MAPK↓, 10,   MAPK↑, 4,   MAPK↝, 2,   p‑MEK↓, 1,   mTOR↓, 23,   mTOR↑, 1,   mTOR↝, 1,   p‑mTOR↓, 4,   P70S6K↓, 1,   PI3K↓, 31,   PI3K↑, 1,   PI3K/Akt↝, 1,   PKCδ↓, 3,   PTEN↓, 1,   PTEN↑, 3,   PTEN↝, 1,   Raf↓, 2,   RAS↓, 1,   p‑S6K↓, 2,   Sp1/3/4↓, 4,   STAT↓, 2,   STAT3↓, 22,   p‑STAT3↓, 3,   TSC2↑, 1,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 5,   ATFs↑, 1,   cJun↓, 1,   cMyc↓, 10,   DLEU1↓, 1,   DNMT1↓, 3,   DNMT1↑, 1,   DNMTs↓, 1,   EZH2↓, 3,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 2,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   HDAC↓, 2,   HDAC1↓, 2,   HDAC2↓, 2,   HDAC3↓, 2,   miR-124-3p↓, 1,   miR-21↓, 1,   miR-21↑, 1,   miR-27a-3p↓, 1,   miR-34a↓, 1,   MYCN↓, 1,   OCT4↓, 4,   other↓, 1,   other↑, 2,   other↝, 2,   PAX2↓, 1,   PhotoS↑, 1,   SOX2↓, 3,   SOX4↓, 2,   SOX9?, 1,   tumCV?, 1,   tumCV↓, 15,   USF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 6,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 11,   GRP78/BiP↑, 2,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 2,   HSP90↓, 1,   PERK↑, 1,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 5,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 10,   p‑Beclin-1/ATG6↑, 1,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3A↑, 1,   LC3B↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 2,   MitoP↑, 1,   p62↓, 1,   p62↑, 1,   PARK2↑, 1,   SESN2↑, 1,   TumAuto↑, 12,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 18,   p16↑, 1,   P53↓, 1,   P53↑, 29,   p‑P53↑, 2,   PARP↓, 1,   PARP↑, 6,   cl‑PARP↑, 7,   cl‑PARP1↑, 1,   PCNA↓, 8,   SIRT6↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TOP2↑, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK1↑, 1,   CDK2↓, 9,   CDK2↑, 2,   CDK4↓, 11,   CDK6↓, 3,   CDK6↑, 1,   CHK1↓, 1,   ChrCon↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 16,   cycE/CCNE↓, 1,   Ki-67↓, 10,   mitA↑, 1,   P21↓, 1,   P21↑, 16,   p27/CDKN1B↑, 3,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 1,   TumCCA↑, 51,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 1,   BMP7/OP1↓, 2,   CD133↑, 1,   cFos↓, 2,   CSCs↓, 7,   EIF4E↓, 1,   FGF↓, 2,   FOSL1↑, 1,   GDF15↓, 1,   Gli↓, 1,   HH↓, 2,   IGF-1↓, 3,   IGFBP3↑, 1,   Ki-67↓, 10,   Nanog↓, 4,   NOTCH↓, 2,   NOTCH↑, 1,   NOTCH1↓, 1,   NOTCH1↑, 1,   Shh↓, 1,   STAT1↓, 1,   TumCG↓, 21,   TumCP↓, 42,   Wnt↓, 8,  

Migration(tgid=13) ⓘ

AP-1↓, 3,   AXL↓, 1,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↓, 2,   Ca+2↑, 4,   i-Ca+2↑, 1,   COL1↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 6,   EMT↓, 19,   EMT↝, 1,   F-actin↓, 1,   FAK↓, 1,   p‑FAK↓, 2,   Fibronectin↓, 1,   LAMs↓, 2,   LRP1↑, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP2↓, 16,   MMP2↑, 1,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 23,   MMP9↑, 2,   MMPs↓, 4,   N-cadherin↓, 6,   NeuroT↓, 1,   PCBP1↓, 1,   PDGF↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug?, 1,   Slug↓, 2,   SMAD2↓, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 3,   TET1↑, 1,   TGF-β↓, 3,   TGF-β1↓, 1,   THBS1↓, 1,   TIMP2↓, 2,   TIMP2↑, 1,   TSP-1↑, 1,   TumCI↓, 20,   TumCMig↓, 20,   TumMeta↓, 10,   TumMeta↑, 1,   Twist↓, 3,   uPA↓, 3,   uPAR↓, 1,   Vim↓, 7,   Zeb1↓, 2,   α-SMA↓, 1,   β-catenin/ZEB1↓, 10,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 17,   EGR1↓, 1,   Hif1a↓, 16,   Hypoxia↓, 1,   NO↓, 2,   NO↑, 3,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 25,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   BBB∅, 1,   GLUT1↓, 4,   MMP↓, 24,   MPT↑, 1,   SLC12A5↓, 1,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 3,   CD47↓, 1,   CD8+↑, 3,   COX2/PTGS2↓, 17,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCL12↓, 1,   CXCR2↓, 1,   CXCR4↓, 3,   DR4↑, 3,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 1,   IL1↓, 2,   IL1↑, 1,   IL10↓, 1,   IL10↑, 2,   IL12↓, 1,   IL1β↓, 4,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 13,   IL8↓, 3,   Imm↑, 5,   Imm↝, 1,   Inflam↓, 5,   pol-M1↑, 2,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   NF-kB?, 1,   NF-kB↓, 25,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 1,   NLRP3↑, 1,   p65↓, 1,   PD-1↓, 1,   PD-L1↓, 4,   PGE2↓, 4,   PSA↓, 1,   PSA∅, 1,   RAGE↓, 1,   Th1 response↑, 1,   Th17↑, 1,   TLR4↓, 3,   TNF-α↓, 10,   TNF-α↑, 3,   TRADD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 4,   BNP↓, 1,   ER-α36↓, 1,   GR↑, 1,   PPARγ↓, 1,   PPARγ↑, 3,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 6,   BioAv↑, 8,   BioAv↝, 2,   BioEnh↑, 2,   chemoR↓, 1,   ChemoSen↑, 40,   CompStab↓, 1,   CompStab↝, 1,   Dose↑, 1,   Dose↝, 17,   eff↓, 13,   eff↑, 12,   eff↝, 1,   eff∅, 1,   GSTA1↓, 1,   GSTM1↑, 1,   Half-Life↓, 1,   Half-Life↝, 2,   MDR1↓, 2,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 4,   P-gp/ABCB1⇅, 1,   RadioS↑, 10,   selectivity↑, 22,   Synergy?, 1,   Synergy↑, 24,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 4,   ALAT↓, 4,   AR↓, 4,   AST↓, 2,   BMD↑, 1,   BRAF↑, 1,   BRAF↝, 1,   BUN↓, 1,   CA19-9↓, 1,   CEA↓, 2,   creat↓, 2,   CRP↓, 2,   EGFR↓, 5,   EGFR↑, 1,   EZH2↓, 3,   Ferritin↓, 1,   Ferritin↑, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   IL6↓, 13,   LDH↓, 6,   LDH↑, 1,   NOS2↑, 1,   PD-L1↓, 4,   PSA↓, 1,   PSA∅, 1,   RAGE↓, 1,   TP53↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 18,   antiCG↓, 1,   antiNeop↑, 1,   AntiTum↑, 5,   cachexia↓, 1,   cardioP↑, 7,   chemoP↑, 13,   chemoPv↑, 4,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↑, 8,   memory↑, 1,   neuroP↑, 1,   NP/CIPN↓, 2,   OS↓, 1,   OS↑, 5,   Pain↓, 1,   PFS↑, 1,   QoL↑, 3,   radioP↑, 8,   RenoP↑, 8,   Risk↓, 3,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 2,   TumVol↓, 9,   TumW↓, 6,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   Bacteria↓, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 6,  
Total Targets: 602

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx?, 2,   antiOx↓, 6,   antiOx↑, 113,   ARE↑, 2,   Bil↑, 2,   Catalase↓, 5,   Catalase↑, 108,   Catalase↝, 1,   Copper↓, 1,   Fenton↓, 3,   GCLC↑, 3,   GCLM↑, 3,   GPx↓, 5,   GPx↑, 81,   GPx∅, 1,   GPx1↑, 1,   GPx4↓, 1,   GPx4↑, 6,   GPx4∅, 1,   GSH↓, 6,   GSH↑, 136,   GSH⇅, 1,   GSH∅, 2,   GSH/GSSG↑, 2,   GSR↓, 3,   GSR↑, 9,   GSSG↓, 6,   GSTs↓, 2,   GSTs↑, 13,   H2O2↓, 9,   H2O2↑, 1,   HDL↓, 1,   HDL↑, 5,   HDL∅, 1,   HNE↓, 1,   HO-1?, 1,   HO-1↓, 5,   HO-1↑, 79,   HO-1⇅, 1,   HO-1∅, 1,   Iron↓, 4,   Iron↝, 1,   i-Iron↓, 3,   i-Iron↑, 1,   Keap1↓, 7,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 61,   lipid-P↑, 1,   mt-lipid-P↓, 1,   MDA?, 1,   MDA↓, 269,   MDA↑, 12,   MDA∅, 1,   MPO↓, 17,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 3,   NQO1↑, 21,   NQO1↝, 1,   Nrf1↑, 1,   NRF2↓, 5,   NRF2↑, 119,   NRF2∅, 1,   p‑NRF2↑, 1,   ONOO↓, 1,   Prx↑, 3,   RNS↓, 3,   ROMO1↑, 1,   ROS?, 2,   ROS↓, 217,   ROS↑, 7,   ROS⇅, 3,   i-ROS↑, 1,   mt-ROS?, 1,   mt-ROS↓, 2,   selenoP↑, 1,   SOD?, 2,   SOD↓, 9,   SOD↑, 183,   SOD↝, 1,   mt-SOD↑, 1,   SOD1↑, 4,   SOD2↑, 2,   TAC↑, 24,   TBARS↓, 5,   Thiols↑, 2,   TOS↓, 2,   Trx↑, 2,   Trx1↑, 2,   TrxR↑, 1,   uricA↓, 3,   VitC↑, 3,   VitE↓, 1,   VitE↑, 1,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↓, 1,   FTH1↑, 1,   FTL↓, 1,   IronCh↓, 1,   IronCh↑, 7,   Mets↝, 1,   TfR1/CD71↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   Insulin↓, 1,   Insulin↑, 2,   mtDam↓, 7,   NGB↑, 1,   OCR↑, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 2,   ACC↓, 1,   ACSL4↓, 2,   ACSL4∅, 1,   adiP↓, 1,   ALAT↓, 38,   ALAT↑, 1,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 13,   ATP↓, 1,   ATP↑, 8,   Buty↑, 1,   cAMP↑, 2,   CRM↑, 2,   DGAT1↓, 1,   FASN↓, 4,   glucose↓, 8,   glucose↝, 1,   GlucoseCon↑, 2,   Glycolysis↑, 1,   GSK‐3β↓, 15,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   H2S↑, 3,   HK2↑, 1,   HMG-CoA↓, 2,   LDL↓, 10,   lipidLev↓, 2,   NAD↑, 1,   NADH:NAD↑, 1,   NADPH↓, 4,   NADPH↑, 3,   PFK↓, 1,   PFK↑, 1,   PKM2↓, 2,   PKM2↑, 1,   PLA2↓, 1,   SCFAs↑, 2,   SIRT1↓, 1,   SIRT1↑, 17,   SREBP1/SREBF1↓, 3,   SREBP2↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 3,   APAF1↓, 1,   Apoptosis↓, 30,   Apoptosis∅, 1,   ASC↓, 1,   BAX↓, 22,   BAX↑, 2,   Bax:Bcl2↓, 2,   Bcl-2↓, 3,   Bcl-2↑, 19,   Bcl-xL↑, 1,   Casp↓, 1,   Casp1↓, 3,   Casp12↓, 1,   Casp3↓, 36,   Casp3↑, 2,   cl‑Casp3↓, 5,   proCasp3↓, 1,   Casp8↓, 2,   Casp9↓, 12,   Casp9↑, 1,   Cyt‑c↓, 6,   Cyt‑c∅, 1,   Fas↓, 1,   Ferroptosis↓, 10,   Ferroptosis↑, 1,   GranB/GZMB↓, 1,   iNOS↓, 42,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 6,   p38↑, 1,   p‑p38↓, 2,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 12,   p‑Akt↓, 4,   p‑Akt↑, 2,   CREB↑, 3,   p‑CREB↑, 2,   ERK↓, 6,   ERK↑, 3,   p‑ERK↓, 2,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IKKα↓, 2,   JAK2↓, 3,   JAK2↑, 3,   p‑JAK2↓, 1,   JNK↓, 12,   JNK↑, 1,   p‑JNK↓, 3,   MAPK?, 1,   MAPK↓, 15,   MAPK↑, 4,   p‑MAPK?, 1,   p‑MAPK↓, 2,   mTOR↓, 3,   mTOR↑, 3,   p‑mTOR↓, 4,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 13,   p‑PI3K↓, 1,   PKA↑, 1,   PKCδ↑, 1,   PP2A↑, 2,   PTEN↓, 1,   STAT↓, 1,   STAT3?, 1,   STAT3↓, 5,   STAT3↑, 2,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   ATF4↑, 1,   cJun↓, 1,   p‑cJun↓, 1,   cMyc↓, 1,   FOXO↑, 1,   FOXO1↑, 1,   FOXO3↑, 2,   HDAC↓, 1,   other?, 3,   other↓, 7,   other↑, 14,   other↝, 5,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 7,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 11,   GRP78/BiP↓, 10,   GRP78/BiP↑, 2,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 6,   HSP70/HSPA5↝, 1,   IRE1↓, 3,   PDI↓, 1,   PERK↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   ATG5↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 2,   LC3II↑, 4,   MitoP↑, 1,   p62↓, 1,   p62↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 10,   P53↓, 2,   PARP1↓, 1,   PCNA↓, 1,   SIRT6↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   cycD1/CCND1↓, 1,   Ki-67↓, 2,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↝, 1,   IGF-1↓, 1,   Ki-67↓, 2,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 3,   NOTCH1↑, 1,   TumCG↓, 1,   TumCP↓, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 7,   AP-1↓, 1,   BACH1↓, 1,   Ca+2↓, 9,   cal2↓, 1,   COL1↓, 3,   COL1↑, 2,   COL3A1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   heparanase↑, 1,   LRP1↑, 2,   MMP13↓, 1,   MMP2↓, 2,   MMP2↑, 1,   MMP9↓, 8,   MMP9↑, 1,   MMPs↓, 1,   MUC1↑, 1,   ROCK1↓, 1,   Sema3A/PlexinA1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 7,   TGF-β↑, 2,   TGF-β1↓, 3,   TGF-β1↑, 2,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 1,   TXNIP↓, 3,   Vim↓, 2,   α-SMA↓, 7,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 1,   eNOS↓, 1,   Hif1a↓, 5,   LOX1↓, 1,   NO?, 1,   NO↓, 43,   NO↑, 3,   VCAM-1↓, 8,   VEGF↓, 4,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 17,   BBB↝, 1,   BBB∅, 2,   GastroP↑, 4,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 5,   MMP↓, 1,   MMP↑, 15,   NHE3↑, 1,   TJ↑, 2,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 3,   TRPM7⇅, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

BALF-Infl↓, 2,   BALF-Lym↓, 1,   CD25+↑, 1,   CD4+↑, 3,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 3,   COX2/PTGS2↓, 52,   COX2/PTGS2↑, 2,   CXCL15↓, 1,   CXCR4↓, 1,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 9,   IFN-γ↓, 6,   IFN-γ↑, 2,   IgE↓, 2,   IL1↓, 3,   IL10↓, 7,   IL10↑, 17,   IL12↓, 4,   IL13↓, 2,   IL17↓, 5,   IL18↓, 2,   IL1β↓, 73,   IL1β↑, 1,   IL2↓, 4,   IL22↓, 1,   IL23↓, 2,   IL33↓, 1,   IL4↓, 8,   IL4↑, 5,   IL5↓, 3,   IL5↑, 1,   IL6?, 1,   IL6↓, 72,   IL6↑, 3,   IL8↓, 11,   Imm↑, 10,   INF-γ↓, 3,   Inflam↓, 147,   Inflam↑, 5,   IP-10/CXCL-10↓, 2,   IRF3↓, 1,   LPS↓, 2,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 8,   MIP2↓, 1,   MyD88↓, 4,   NeuroI↓, 7,   Neut↓, 1,   NF-kB↓, 77,   NK cell↑, 1,   NLRP3↓, 18,   p65↓, 4,   PGE2↓, 18,   PGE2↑, 2,   RAGE↓, 3,   RANTES↓, 2,   SOCS-3↓, 1,   Th2↓, 1,   TLR2↓, 3,   TLR4↓, 25,   TNF-α↓, 104,   TNF-α↑, 3,   TRAF1↓, 1,   TRAF6↓, 1,   Treg lymp↝, 1,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

Astr↓, 1,   GFAP↓, 3,   GGT/CD224↓, 1,   MGlio↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 5,   Ach↑, 6,   AChE↓, 42,   AChE↝, 1,   ADAM10↑, 1,   BChE↓, 7,   BDNF↑, 30,   BDNF⇅, 1,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 8,   ChE↓, 1,   GABA↑, 2,   GDNF↑, 1,   MAOA↓, 4,   MAOB↓, 2,   monoA↑, 1,   NGF↑, 6,   PSD95↑, 5,   RELN↑, 1,   SNAP25↑, 2,   TPH1↓, 1,   TrkB↑, 5,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APOE4↓, 1,   APP↓, 7,   cl‑APP↑, 1,   Aβ↓, 42,   Aβ42↓, 2,   BACE/β-secretase↓, 19,   PSEN1/PS1↓, 1,   PSEN1/PS1↑, 1,   tau↓, 11,   p‑tau↓, 10,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   BNP↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   FGF21↑, 1,   GLP-1R↑, 1,   GR↑, 2,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 25,   BioAv↑, 38,   BioAv⇅, 1,   BioAv↝, 12,   BioEnh↑, 1,   ChemoSen↑, 1,   CompStab↝, 1,   CYP2D6↓, 1,   CYP2E1↓, 3,   Dose?, 5,   Dose↓, 1,   Dose↑, 5,   Dose↝, 37,   eff↓, 4,   eff↑, 29,   eff↝, 3,   GSTA1↑, 2,   Half-Life↓, 3,   Half-Life↑, 2,   Half-Life↝, 9,   P-gp/ABCB1↓, 1,   P450↑, 1,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 14,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 38,   ALAT↑, 1,   ALB↑, 1,   ALP↓, 6,   AST↓, 39,   AST↑, 1,   BG↓, 1,   Bil↑, 2,   BloodF↑, 1,   BMD↑, 3,   BP↓, 6,   BP↝, 1,   BP∅, 1,   BUN?, 1,   BUN↓, 6,   CEA↓, 2,   CK/CK-MB↓, 1,   creat↓, 13,   CRP↓, 13,   Ferritin↑, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 72,   IL6↑, 3,   LDH↓, 14,   LDH↑, 2,   LDH∅, 1,   NOS2↓, 3,   RAGE↓, 3,   SpO2↑, 1,   TC↓, 2,   TG/TAG↓, 3,   Urea↓, 3,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 3,   AirwayM↓, 1,   AntiAge↑, 3,   antiAll?, 1,   antiAll↑, 18,   AntiArt↑, 5,   AntiCan↑, 14,   antiCG↑, 1,   AntiDiabetic↑, 23,   antiPs↑, 3,   AntiTum↑, 1,   ANXi↓, 1,   BOLD↑, 1,   cardioP?, 1,   cardioP↑, 40,   CardioT↓, 1,   chemoP↑, 13,   chemoPv↑, 1,   cognitive↓, 1,   cognitive↑, 56,   cognitive∅, 1,   diuretic↑, 1,   hepatoP↓, 3,   hepatoP↑, 63,   Learn↑, 10,   memory↑, 63,   Mood↑, 4,   motorD↑, 6,   Mucositis↓, 1,   neuroP↑, 109,   NP/CIPN↓, 1,   Obesity↓, 10,   OS↑, 4,   Pain↓, 5,   QoL↑, 2,   radioP↑, 7,   RenoP↓, 1,   RenoP↑, 28,   Risk↓, 5,   Sleep↑, 3,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 13,   toxicity↓, 27,   toxicity↑, 2,   toxicity↝, 7,   toxicity∅, 5,   Weight↓, 1,   Weight↑, 3,   Weight∅, 1,   Wound Healing↑, 8,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 8,   AntiFungal↑, 4,   AntiP↑, 1,   AntiViral↑, 6,   Bacteria↓, 11,   Diar↓, 3,   GutMicro↑, 28,   Inf↓, 1,   Sepsis↓, 9,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 3,   Ingr↝, 4,  
Total Targets: 611

Scientific Paper Hit Count for: MDA, Serum malondialdehyde
17 Curcumin
14 Thymoquinone
12 Hydrogen Gas
11 Silver-NanoParticles
11 Boron
11 Lycopene
11 Quercetin
10 Silymarin (Milk Thistle) silibinin
9 Luteolin
8 Magnetic Fields
7 Propolis -bee glue
6 doxorubicin
6 Betulinic acid
6 Carvacrol
6 Chlorogenic acid
6 Ferulic acid
5 Cisplatin
5 Baicalein
5 Crocetin
5 isoorientin
5 Sulforaphane (mainly Broccoli)
5 Kaempferol
5 L-Theanine
5 Matrine
5 Moringa oleifera
5 Morin
5 Shikonin
4 Resveratrol
4 Alpha-Lipoic-Acid
4 Astaxanthin
4 Berberine
4 Vitamin C (Ascorbic Acid)
4 Chrysin
4 Hyperoside
4 Rosmarinic acid
4 Rutin
3 Allicin (mainly Garlic)
3 Apigenin (mainly Parsley)
3 Melatonin
3 Radiotherapy/Radiation
3 Benzyl isothiocyanate
3 Phenethyl isothiocyanate
3 α-Bisabolol / Chamomile oil
3 Centella asiatica / Gotu kola → asiaticoside
3 Chemotherapy
3 Spirulina(Arthrospira/Limnospira)
3 EGCG (Epigallocatechin Gallate)
3 Selenium NanoParticles
3 Selenite (Sodium)
3 Vitexin
2 1,8-Cineole
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Andrographis
2 Artemisinin
2 Ashwagandha(Withaferin A)
2 Ascorbyl Palmitate
2 Allyl isothiocyanate
2 borneol
2 Selenium
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Carvone
2 Copper and Cu NanoParticles
2 Chlorella (Chlorella vulgaris)
2 Dandelion Root
2 Emodin
2 Sesame seeds and Oil
2 Gallic acid
2 Graviola
2 HydroxyCitric Acid
2 Isoliquiritigenin
2 Isovitexin
2 Juglone
2 Licochalcone A
2 Licorice
2 Linalool
2 Magnolol
2 Lemon Balm/Melissa officinalis
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Piperlongumine
2 Pterostilbene
1 3-bromopyruvate
1 cetuximab
1 5-Hydroxytryptophan
1 Anthocyanins
1 Paclitaxel/Taxol
1 Baicalin
1 Biochanin A
1 Bromelain
1 Boswellia (frankincense)
1 Caffeic acid
1 Carnosic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celastrol
1 chitosan
1 Chlorophyllin
1 Chocolate
1 Cichoric acid / Chicoric acid
1 Cinnamon
1 Citric Acid
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Galantamine
1 Diclofenac
1 Docosahexaenoic Acid
1 diet Methionine-Restricted Diet
1 Diindolylmethane
1 D-limonene
1 Ellagic acid
1 Eurycomanone
1 Eugenol
1 Formononetin
1 Flaxseed/Linseed
1 Flaxseed Oil
1 Fucoidan
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Huperzine A/Huperzia serrata
1 Isobavachalcone
1 isoquercitrin
1 Isothiocyanates
1 Ivermectin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Vitamin E
1 Metformin
1 Magnetic Field Rotating
1 Magnesium
1 Methylsulfonylmethane
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Myricetin
1 Oleuropein
1 HydroxyTyrosol
1 Aromatherapy
1 buckwheat sprouts
1 Orlistat
1 salinomycin
1 Sulfasalazine
1 Anti-oxidants
1 Date Fruit Extract
1 Sesamin
1 Lignans
1 Shankhpushpi
1 Silicic Acid
1 Safflower yellow
1 Taurine
1 5-fluorouracil
1 Urolithin
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:570  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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