HO-1 Cancer Research Results

HO-1, HMOX1: Click to Expand ⟱
Source:
Type:
(Also known as Hsp32 and HMOX1)
HO-1 is the common abbreviation for the protein (heme oxygenase‑1) produced by the HMOX1 gene.
HO-1 is an enzyme that plays a crucial role in various cellular processes, including the breakdown of heme, a toxic molecule. Research has shown that HO-1 is involved in the development and progression of cancer.
-widely regarded as having antioxidant and cytoprotective effects
-The overall activity of HO‑1 helps to reduce the pro‐oxidant load (by degrading free heme, a pro‑oxidant) and to generate molecules (like bilirubin) that can protect cells from oxidative damage

Studies have found that HO-1 is overexpressed in various types of cancer, including lung, breast, colon, and prostate cancer. The overexpression of HO-1 in cancer cells can contribute to their survival and proliferation by:
  Reducing oxidative stress and inflammation
  Promoting angiogenesis (the formation of new blood vessels)
  Inhibiting apoptosis (programmed cell death)
  Enhancing cell migration and invasion
When HO-1 is at a normal level, it mainly exerts an antioxidant effect, and when it is excessively elevated, it causes an accumulation of iron ions.

A proper cellular level of HMOX1 plays an antioxidative function to protect cells from ROS toxicity. However, its overexpression has pro-oxidant effects to induce ferroptosis of cells, which is dependent on intracellular iron accumulation and increased ROS content upon excessive activation of HMOX1.

-Curcumin   Activates the Nrf2 pathway leading to HO‑1 induction; known for its anti‑inflammatory and antioxidant effects.
-Resveratrol  Induces HO‑1 via activation of SIRT1/Nrf2 signaling; exhibits antioxidant and cardioprotective properties.
-Quercetin   Activates Nrf2 and related antioxidant pathways; contributes to anti‑oxidative and anti‑inflammatory responses.
-EGCG     Promotes HO‑1 expression through activation of the Nrf2/ARE pathway; also exhibits anti‑inflammatory and anticancer properties.
-Sulforaphane One of the most potent natural HO‑1 inducers; triggers Nrf2 nuclear translocation and upregulates a battery of phase II detoxifying enzymes.
-Luteolin    Induces HO‑1 via Nrf2 activation; may also exert anti‑inflammatory and neuroprotective effects in various cell models.
-Apigenin   Has been reported to induce HO‑1 expression partly via the MAPK and Nrf2 pathways; also known for anti‑inflammatory and anticancer activities.
Scientific Papers found: Click to Expand⟱
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp/ABCB1↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2/PTGS2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp/ABCB1↓, Synergy↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,
4908- Sal,    Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
tumCV↓, ROS↑, lipid-P↑, UPR↑, ER Stress↑, NRF2↓, NADPH↓, HO-1↓, SOD↓, Catalase↓, GPx↓, eff↓, TumCP↓,
1090- SANG,    Sanguinarine inhibits invasiveness and the MMP-9 and COX-2 expression in TPA-induced breast cancer cells by inducing HO-1 expression.
- in-vitro, BC, MCF7
MMP9↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, AP-1↓, p‑Akt↓, p‑ERK↓, HO-1↑,
4726- Se,  Oxy,    Oxygen therapy accelerates apoptosis induced by selenium compounds via regulating Nrf2/MAPK signaling pathway in hepatocellular carcinoma
- in-vivo, HCC, NA
eff↝, NRF2↓, p‑p38↑, Apoptosis↑, eff↑, TumVol↓, other↝, toxicity↓, Dose↝, NRF2↝, HO-1↓, Catalase↓, SOD↓, e-pH↓, pH∅, MAPK↑, eff↑,
4190- Sesame,    Sesame Seeds: A Nutrient-Rich Superfood
- Review, Nor, NA
*antiOx↑, *LDL↓, *Aβ↓, *TNF-α↓, *SOD↑, *SIRT1↑, *Catalase↑, *GSH↑, *MDA↓, *GSTs↑, *IL4↑, *GPx↑, *COX2/PTGS2↓, *PGE2↓, *NO↓, CDK2↑, COX2/PTGS2↑, MMP9↑, ICAM-1↓, *BDNF↑, *PPARγ↑, *AChE↓, *Inflam↓, *HO-1↑, *NF-kB↓, *ROS↓,
4199- SFN,    Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders
- Review, AD, NA - Review, Park, NA
*BBB↑, *BDNF↑, *neuroG↑, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *HSPs↑, *GSTs↑, *Trx↑, *GPx↑, *GSR↑, *GSH↑, *NQO1↑, *GutMicro↑, *Inflam↓, *neuroP↑,
3663- SFN,    Efficacy of Sulforaphane in Neurodegenerative Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *Half-Life↝, *NRF2↑, *NQO1↑, *HO-1↑, *TrxR↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *Aβ↓, *GSH↑, *cognitive↑, *BACE/β-secretase↓, *HSP70/HSPA5↑, *neuroP↑, *ROS↓, *BBB↑, *MMP9↓,
3660- SFN,    Sulforaphane - role in aging and neurodegeneration
- Review, AD, NA
*antiOx↑, *Inflam↓, *NRF2↑, *NF-kB↓, *HDAC↓, *DNMTs↓, *neuroP↑, *AntiAge↑, *DNMT1↓, *DNMT3A↓, *memory↑, *HO-1↑, *ROS↓, *NO↓, *GSH↑, *NF-kB↓, *TNF-α↓, *IL10↑,
3658- SFN,    Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer’s Disease
- Review, AD, NA
*NRF2↑, *antiOx↑, *neuroP↑, *Aβ↓, *BACE/β-secretase↓, *NQO1↑, *IL1β↓, *TNF-α↓, *IL6↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *NLRP3↓, *Ca+2↓, *GSH↑, *MDA↓, *ROS↓, *SOD↑, *HO-1↑, *TrxR↑, *cognitive↑, *tau↓, *HSP70/HSPA5↑,
3657- SFN,    Sulforaphane exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages
- in-vitro, AD, THP1
*NLRP3↓, *Inflam↓, *IL1β↓, *NRF2↑, *HO-1↑,
3184- SFN,    The Integrative Role of Sulforaphane in Preventing Inflammation, Oxidative Stress and Fatigue: A Review of a Potential Protective Phytochemical
- Review, Nor, NA
*NRF2↑, *Inflam↓, *NF-kB↓, *ROS↓, *BioAv↝, *BioAv↝, *BioAv↝, *BioAv↝, *cardioP↑, *GPx↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *NADPH↑, *NQO1↑, *LDH↓, *hepatoP↑, *ALAT↓, *AST↓, *IL6↓,
3192- SFN,    Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention
- in-vitro, Pca, PC3
Sp1/3/4↓, selectivity↑, NRF2↑, HDAC↓, DNMTs↓, TumCCA↑, selectivity↑, HO-1↑, NQO1↑, CDK2↓, TumCP↓, BID↑, Smad1↑, Diablo↑, ICAD↑, Cyt‑c↑, IAP1↑, HSP27↑, *Cyt‑c↓, *IAP1↓, *HSP27↓, survivin↓, CDK4↓, VEGF↓, AR↓,
2553- SFN,    Mechanistic review of sulforaphane as a chemoprotective agent in bladder cancer
- Review, Bladder, NA
antiOx↓, Inflam↓, ChemoSen↑, ROS⇅, *NRF2↑, *GSH↑, Catalase↑, HO-1↑, NAD↑, chemoP↑,
2552- SFN,  Chemo,    Chemopreventive activity of sulforaphane
- Review, Var, NA
chemoPv↑, TumCG↓, *ROS↓, *Inflam↓, *Dose↝, *NRF2↑, *HO-1↑, *NQO1↑, NF-kB↓, ROS↑,
1437- SFN,    Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition
- Review, Var, NA
HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, HDAC8↓, eff↑, ac‑HSP90↑, DNMT1↓, DNMT3A↓, hTERT/TERT↓, NRF2↑, HO-1↑, NQO1↑, miR-155↓, miR-200c↑, SOX9↓, *toxicity↓,
1431- SFN,    Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts
- in-vivo, Nor, NA
*NADPH↑, *NQO1↑, *GSTA1↑, *HO-1↑,
1482- SFN,    Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: the involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway
- in-vitro, Bladder, T24/HTB-9
tumCV↓, Apoptosis↑, Cyt‑c↑, Bax:Bcl2↑, Casp9↑, Casp3↑, Casp8∅, cl‑PARP↑, ROS↑, MMP↓, eff↓, ER Stress↑, p‑NRF2↑, HO-1↑,
1429- SFN,    Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast
- in-vivo, Nor, NA - Human, Nor, NA
*NADPH↑, *NQO1↑, *HO-1↑, *Risk↑,
1722- SFN,    Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems
- Review, Var, NA
TumCCA↑, CYP1A1↓, CYP3A4↓, Cyt‑c↑, Casp9↑, Apoptosis↑, ROS↑, MAPK↑, P53↑, BAX↑, ChemoSen↑, HDAC↓, GSH↓, HO-1↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3302- SIL,    Protective effects of silymarin in glioblastoma cancer cells through redox system regulation
- in-vitro, GBM, U87MG
NRF2↑, HO-1↑, Trx↑, antiOx↑,
3315- SIL,    Silymarin alleviates docetaxel-induced central and peripheral neurotoxicity by reducing oxidative stress, inflammation and apoptosis in rats
- in-vivo, Nor, NA
neuroP↑, *NRF2↑, *HO-1↑, *lipid-P↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *NF-kB↓, *TNF-α↓, *JNK↓, *Bcl-2↑, *BAX↑,
3307- SIL,    Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications
- Review, Var, NA
*NRF2↑, *antiOx↑, *chemoP↑, *Inflam↓, *BioAv↑, Synergy↑, *NQO1↑, TNF-α↓, IL6↓, *GSH↑, *ROS↓, *MDA↓, Synergy↑, *hepatoP↑, *GPx↑, *SOD↑, *Catalase↑, *HO-1↑, *neuroP↑,
3310- SIL,    Silymarin attenuates paraquat-induced lung injury via Nrf2-mediated pathway in vivo and in vitro
- in-vitro, Lung, A549
Inflam↓, MPO↓, NO↓, iNOS↓, ROS↓, MDA↑, SOD↑, Catalase↑, GPx↑, NRF2↑, HO-1↑, NADPH↑,
3313- SIL,    Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats
- in-vivo, Nor, NA
*NRF2↑, *HO-1↑, *creat↓, *BUN↓, *RenoP↑, *MDA↓, *TNF-α↓, *IL1β↓, *Cyt‑c↓, *Casp3↓, *GSTs↓, *GSH↑, *GPx4↑, *SOD↑, *GSR↓, *Ferroptosis↓,
3318- SIL,    Pharmaceutical prospects of Silymarin for the treatment of neurological patients: an updated insight
- Review, AD, NA - Review, Park, NA
*hepatoP↑, *neuroP↑, *TLR4↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *memory↑, *cognitive↑, *NRF2↑, *HO-1↑, *ROS↓, *Akt↑, *mTOR↑, *SOD↑, *Catalase↑, *GSH↑, *IL10↑, *IL6↑, *NO↓, *MDA↓, *AChE↓, *MAPK↓, *BDNF↑,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2/PTGS2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,
3316- SIL,  Chemo,    Silymarin Nanoparticles Counteract Cognitive Impairment Induced by Doxorubicin and Cyclophosphamide in Rats; Insights into Mitochondrial Dysfunction and Nrf2/HO-1 Axis
- in-vivo, Nor, NA
Inflam↓, antiOx↓, neuroP↑, cognitive↑, NRF2↑, HO-1↑, memory↑, AChE↓, Casp3↓,
3324- SIL,    Silymarin prevents NLRP3 inflammasome activation and protects against intracerebral hemorrhage
- in-vivo, Stroke, NA
*ROS↓, *TAC↑, *NF-kB↓, *IL2↓, *NRF2↑, *HO-1↑, *neuroP↑, *Inflam↓, *NLRP3↓,
1346- SK,    An Oxidative Stress Mechanism of Shikonin in Human Glioma Cells
- in-vitro, GBM, U87MG - in-vitro, GBM, Hs683
NRF2↓, ROS↑, Apoptosis↑, Cyt‑c↑, GSH↓, MMP↓, P53↑, HO-1⇅,
2201- SK,    Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice
- in-vitro, PSA, HaCaT - in-vivo, NA, NA
*eff↑, *IL6↓, *IL17↓, *TNF-α↓, *lipid-P↑, *NRF2↓, *HO-1↝, *NCOA4↝, *GPx4↓, *Ferroptosis↓, *Inflam↓, *ROS↓, *Iron↓,
2196- SK,    Research progress in mechanism of anticancer action of shikonin targeting reactive oxygen species
- Review, Var, NA
*ALAT↓, *AST↓, *Inflam?, *EMT↑, ROS?, TrxR1↓, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, IRE1↑, JNK↑, eff↝, DR5↑, Glycolysis↓, PKM2↓, ChemoSen↑, GPx4↓, HO-1↑,
2195- SK,    Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS-regulated HIF-1α/HO-1 axis
- in-vitro, OS, NA
TumCP↓, Ferroptosis↓, Hif1a↑, HO-1↑, Iron↑, ROS↑, GSH/GSSG↓, GPx4↓,
2220- SK,    Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *SIRT1↓, *NRF2↑, *HO-1↑, *GSH↑, *TAC↑, *SOD↑, *MDA↓, *NO↓, *iNOS↓, *NHE3↑, *PI3K↑,
2217- SK,    Shikonin Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis to Attenuate Renal Ischemia/Reperfusion Injury by Activating the Sirt1/Nrf2/HO-1 Pathway
- in-vivo, Nor, NA - in-vitro, Nor, HK-2
*ER Stress↓, *SIRT1↑, *NRF2↑, *HO-1↑, *eff↓, *RenoP↑, *GRP78/BiP↓, *CHOP/DDIT3↓, *Casp12↓, *BAX↓, *cl‑Casp3↓,
2214- SK,    Shikonin Attenuates Cochlear Spiral Ganglion Neuron Degeneration by Activating Nrf2-ARE Signaling Pathway
- in-vitro, Nor, NA
*NRF2↑, *HO-1↑, *NQO1↑, *antiOx↑, *neuroP↑, *ROS↓, *MDA↓, *SOD↑, GSH↑,
2218- SK,    Shikonin Alleviates Endothelial Cell Injury Induced by ox-LDL via AMPK/Nrf2/HO-1 Signaling Pathway
- in-vitro, Nor, HUVECs
*Dose↝, *Apoptosis↓, *Casp3↓, *Bcl-2↑, *Inflam↓, *VCAM-1↓, *ICAM-1↓, *E-sel↓, *ROS↓, *SOD↑, *AMPK↑, *NRF2↑, *HO-1↑, *TNF-α↓, *IL1β↓, *IL6↓,
3042- SK,    The protective effects of Shikonin on lipopolysaccharide/D -galactosamine-induced acute liver injury via inhibiting MAPK and NF-kB and activating Nrf2/HO-1 signaling pathways
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *IFN-γ↓, *ALAT↓, *AST↓, *MPO↓, *ROS↓, *JNK↓, *ERK↓, *p38↓, *NF-kB↓, *p‑IKKα↓, *SOD↑, *GSH↑, *HO-1↑, *NRF2↑, *hepatoP↑,
4892- Sper,  erastin,    Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer
- in-vitro, Pca, PC3 - in-vivo, Pca, NA
Ferroptosis↑, lipid-P↑, Iron↑, Synergy↑, HO-1↑, NRF2↑, ROS↑, AntiTum↑, eff↓,
4731- SSE,    Dietary selenium mitigates cadmium-induced apoptosis and inflammation in chicken testicles by inhibiting oxidative stress through the activation of the Nrf2/HO-1 signaling pathway
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *H2O2↓, *Catalase↑, *GSH↑, *NRF2↑, *HO-1↑, *Bcl-2↑, *other↝,
3960- Taur,    Versatile Triad Alliance: Bile Acid, Taurine and Microbiota
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *Inflam↓, *GABA↑, *memory↑, *cognitive↑, *iNOS↓, *CRP↓, *HO-1↑, *Prx↑, *Trx↑, *NRF2↑, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *MDA↓, *eff↝, *GutMicro↑, other↑,
1935- TQ,    Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
- Review, OS, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, ROS↑, P53↑, Twist↓, E-cadherin↑, N-cadherin↓, NF-kB↓, IL8↓, XIAP↓, Bcl-2↓, STAT3↓, MAPK↓, PI3K↓, Akt↓, ERK↓, MMP2↓, MMP9↓, *ROS↓, HO-1↑, selectivity↑, TumCG↓,
2128- TQ,    Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo
- in-vivo, Nor, NA
*COX2/PTGS2↓, *NF-kB↓, *p‑Akt↓, *p‑cJun↓, *p‑p38↓, *HO-1↑, *NADPH↑, *GSTA1↑, *antiOx↑, *Inflam↓, *NQO1↑, *GCLC↑, *GSTA1↑,
2130- TQ,    Thymoquinone Attenuates Brain Injury via an Anti-oxidative Pathway in a Status Epilepticus Rat Model
- in-vivo, Nor, NA
*eff↑, *memory↑, *NRF2↑, *HO-1↑, *SOD↑, *ROS↓,
2131- TQ,    Therapeutic impact of thymoquninone to alleviate ischemic brain injury via Nrf2/HO-1 pathway
- in-vitro, Stroke, NA - in-vivo, Nor, NA
*eff↑, *OS↑, *Inflam↓, *ROS↓, *NRF2↑, *HO-1↑,
2132- TQ,    Thymoquinone treatment modulates the Nrf2/HO-1 signaling pathway and abrogates the inflammatory response in an animal model of lung fibrosis
- in-vivo, Nor, NA
*Weight∅, *antiOx↑, *lipid-P↓, *MMP7↓, *Casp3↓, *BAX↓, *TGF-β↓, *Diff↑, *NRF2↓, *HO-1↓, *NF-kB↓, *IκB↑,
2133- TQ,  CUR,  Cisplatin,    Thymoquinone and curcumin combination protects cisplatin-induced kidney injury, nephrotoxicity by attenuating NFκB, KIM-1 and ameliorating Nrf2/HO-1 signalling
- in-vitro, Nor, HEK293 - in-vivo, NA, NA
*creat↓, *TNF-α↓, *IL6↓, *MRP↓, *GFR↑, *mt-ATPase↑, *p‑Akt↑, *NRF2↑, *HO-1↑, *Casp3↓, *NF-kB↓, *RenoP↑,
2134- TQ,    Modulation of Nrf2/HO1 Pathway by Thymoquinone to Exert Protection Against Diazinon-induced Myocardial Infarction in Rats
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *MDA↓, *ROS↓, *GSSG↓, *GSH↑, *VitE↑, *VitC↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *cardioP↑, *GSH/GSSG↑, *GPx↑,
2135- TQ,    Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets
- in-vitro, Nor, HaCaT
*HO-1↑, *NRF2↑, *e-ERK↑, *e-Akt↑, *AMPKα↑, *ROS⇅, *eff↓, *tumCV∅,

Showing Research Papers: 301 to 350 of 366
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 366

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 6,   Catalase↓, 6,   Catalase↑, 9,   Copper↑, 1,   Fenton↑, 8,   GCLC↑, 2,   GPx↓, 3,   GPx↑, 6,   GPx1↓, 2,   GPx4↓, 16,   GPx4∅, 1,   GSH↓, 23,   GSH↑, 8,   GSH/GSSG↓, 4,   GSR↓, 1,   GSR↑, 3,   GSS↑, 1,   GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 5,   H2O2↑, 4,   HNE↑, 1,   HO-1↓, 46,   HO-1↑, 74,   HO-1⇅, 1,   HO-1↝, 2,   HO-2↓, 1,   Iron↑, 13,   i-Iron↑, 1,   Keap1↓, 2,   Keap1↝, 1,   lipid-P↓, 3,   lipid-P↑, 14,   MDA↓, 5,   MDA↑, 11,   MPO↓, 2,   NADH↓, 1,   NFE2L2↑, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↓, 5,   NQO1↑, 11,   Nrf1↑, 1,   NRF2↓, 33,   NRF2↑, 46,   NRF2⇅, 1,   NRF2↝, 2,   NRF2∅, 1,   p‑NRF2↑, 1,   Prx↓, 1,   Prx4↑, 1,   PrxII↓, 1,   ROS?, 2,   ROS↓, 23,   ROS↑, 99,   ROS⇅, 2,   ROS↝, 1,   mt-ROS↑, 2,   SOD?, 1,   SOD↓, 5,   SOD↑, 10,   SOD1↑, 3,   SOD2↓, 5,   SOD2↑, 2,   T-SOD↓, 1,   Trx↓, 1,   Trx↑, 2,   ox-Trx1↑, 1,   TrxR↓, 4,   TrxR1↓, 2,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FTH1↓, 1,   FTH1↑, 1,   FTL↑, 1,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 3,   CDC25↓, 1,   compI↓, 1,   compII↓, 1,   EGF↓, 1,   ETC↓, 3,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 2,   MKK7↓, 1,   mtDam↑, 6,   OCR↓, 1,   OCR↑, 2,   OXPHOS↓, 2,   OXPHOS↑, 2,   PDH↝, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↑, 1,   ACLY↓, 1,   ACSL4↑, 2,   ACSL4↝, 1,   ALAT↓, 2,   AMPK↑, 10,   ATP↓, 7,   ATP↑, 2,   CRM↑, 1,   ECAR↓, 1,   ECAR↝, 1,   FASN↓, 3,   G6PD↓, 1,   GLS↓, 1,   glucose↓, 1,   GlucoseCon↓, 4,   GlutMet↓, 1,   Glycolysis↓, 13,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 3,   HK2↓, 6,   lactateProd↓, 5,   lactateProd↑, 1,   LDHA↓, 3,   LDL↓, 1,   NAD↑, 1,   NADPH↓, 3,   NADPH↑, 2,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 2,   PFK↓, 1,   PKM2↓, 4,   SCD1↓, 2,   SIRT1↓, 4,   SIRT1↑, 4,   SREBP2↓, 1,   TCA↓, 2,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 2,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 62,   ASC↓, 1,   BAD↑, 1,   BAX↓, 2,   BAX↑, 28,   Bax:Bcl2↑, 7,   Bcl-2↓, 32,   Bcl-xL↓, 5,   BID↑, 1,   BIM↑, 5,   Casp↑, 7,   Casp↝, 1,   Casp1↓, 1,   Casp10↑, 1,   Casp3↓, 2,   Casp3↑, 32,   cl‑Casp3↑, 7,   cl‑Casp3⇅, 1,   Casp7↑, 4,   cl‑Casp7↑, 1,   Casp8↑, 9,   Casp8∅, 1,   cl‑Casp8↑, 1,   Casp9↑, 19,   cl‑Casp9↑, 8,   cFLIP↓, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 29,   Diablo↑, 6,   DR5↑, 9,   Fas↑, 4,   FasL↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 19,   GSDMD↑, 1,   HEY1↓, 1,   IAP1↓, 1,   IAP1↑, 1,   IAP2/BIRC3↓, 2,   ICAD↑, 1,   iNOS↓, 9,   Mcl-1?, 1,   Mcl-1↓, 8,   MDM2↓, 6,   p‑MDM2↓, 1,   MOMP↑, 1,   NOXA↑, 1,   p38↓, 3,   p38↑, 7,   p‑p38↑, 3,   pS2/TFF1↓, 1,   PUMA↑, 2,   Pyro↑, 1,   survivin↓, 18,   TNFR 1↑, 1,   TRAILR↑, 2,   TumCD↓, 1,   TumCD↑, 5,   XIAP↓, 17,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 50,   Akt↑, 3,   p‑Akt↓, 18,   AMPKα↑, 2,   p‑CaMKII ↓, 1,   CIP2A↓, 2,   CK2↓, 1,   cMET↓, 2,   p‑cMET↑, 1,   p‑CREB↑, 1,   EGFR↓, 14,   EGFR↑, 1,   ERK↓, 19,   ERK↑, 1,   p‑ERK↓, 3,   p‑ERK↑, 1,   ERK5↓, 1,   HER2/EBBR2↓, 4,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↝, 1,   HRAS↓, 1,   IGF-1R↓, 2,   IKKα↓, 5,   IκB↓, 1,   JAK↓, 4,   JAK↝, 1,   JAK1↓, 1,   JAK2↓, 4,   JNK↓, 2,   JNK↑, 10,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAPK↓, 9,   MAPK↑, 12,   MAPK↝, 2,   MKK4↓, 1,   mTOR↓, 34,   mTOR↝, 1,   p‑mTOR↓, 4,   p70S6↓, 2,   P70S6K↓, 3,   p‑P70S6K↓, 1,   p85S6K↓, 1,   PDGFR-BB↓, 2,   PI3K↓, 38,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 5,   PI3K/Akt↓, 2,   PKCδ↓, 7,   PTEN↓, 2,   PTEN↑, 12,   Raf↓, 1,   RAS↓, 5,   RAS↑, 1,   RET↓, 1,   Sp1/3/4↓, 7,   Src↓, 1,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 23,   STAT3↑, 1,   p‑STAT3↓, 3,   STAT5↓, 1,   STAT6↓, 1,   p‑STAT6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 3,   ATF4↓, 1,   ATF4↑, 6,   ATF4↝, 1,   ATFs↑, 1,   cJun↓, 4,   cMyc↓, 13,   p‑cMyc↑, 1,   DNMT1↓, 3,   DNMT3A↓, 2,   DNMTs↓, 6,   EZH2↓, 3,   FOXM1↓, 1,   FOXO↑, 2,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 3,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 1,   H3↑, 1,   ac‑H3↓, 1,   H3K9↓, 1,   H4↓, 1,   ac‑H4↓, 1,   HATs↓, 2,   HDAC↓, 11,   HDAC1↓, 4,   HDAC2↓, 2,   HDAC3↓, 1,   HDAC8↓, 1,   HES1↓, 1,   miR-124-3p↓, 1,   miR-155↓, 1,   miR-19b↓, 1,   miR-200c↑, 1,   miR-21↓, 1,   miR-27a-3p↓, 1,   miR-34a↑, 1,   miR-34b-5p↑, 1,   miR-384↑, 1,   Myc↓, 2,   MYCN↑, 1,   OCT4↓, 3,   OLIG2↓, 1,   other?, 1,   other↓, 2,   other↑, 3,   other⇅, 1,   other↝, 2,   PhotoS↑, 1,   SOX2↓, 4,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 2,   SOX9↑, 1,   SUV39H↓, 1,   TET3↑, 1,   tumCV?, 1,   tumCV↓, 18,   USF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 17,   eIF2α↓, 1,   eIF2α↑, 3,   p‑eIF2α↑, 3,   ER Stress↑, 19,   GRP78/BiP↑, 3,   HSF1↓, 1,   HSP27↓, 5,   HSP27↑, 1,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 3,   HSP72↓, 1,   HSP90↓, 9,   ac‑HSP90↑, 1,   IRE1↑, 3,   NQO2↑, 1,   PERK↑, 5,   p‑PERK↑, 1,   UPR↑, 4,   XBP-1↓, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 1,   ATG7↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 8,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 2,   p62↓, 5,   p62↑, 1,   SESN2↑, 1,   TumAuto↑, 13,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 19,   hTERT/TERT↓, 3,   p16↑, 1,   P53↓, 2,   P53↑, 37,   P53↝, 1,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 6,   cl‑PARP↓, 1,   cl‑PARP↑, 21,   PCNA↓, 10,   POLD1↓, 1,   SIRT6↑, 1,   Telomerase↓, 3,   TOP1↓, 1,   TOP2↓, 2,   TP53↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

AURKB↓, 1,   CDK1↓, 7,   CDK1↑, 1,   CDK2↓, 16,   CDK2↑, 2,   CDK4↓, 19,   CDK6↓, 9,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 1,   Chk2↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 4,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 25,   cycE/CCNE↓, 7,   Ki-67↓, 8,   MAD↓, 1,   mitA↑, 1,   P21↓, 1,   P21↑, 22,   p27/CDKN1B↑, 8,   RB1↓, 1,   p‑RB1↓, 3,   Securin↓, 1,   TumCCA↑, 51,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMP7/OP1↓, 1,   BMPs↑, 3,   CD133↓, 2,   CD133↑, 1,   CD34↓, 1,   cFos↓, 4,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 15,   Diff↑, 2,   FOSL1↑, 1,   Gli↓, 1,   HH↓, 2,   IGF-1↓, 6,   Ki-67↓, 8,   mTORC1↓, 1,   Nanog↓, 4,   Nestin↓, 1,   NICD↓, 1,   NOTCH↓, 7,   NOTCH↑, 1,   NOTCH1↓, 6,   NOTCH1↑, 1,   NOTCH3↓, 1,   Shh↓, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 26,   TumCG↑, 1,   TumCP↓, 52,   Wnt↓, 18,   Wnt↝, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AP-1↓, 6,   AP-1↑, 1,   AXL↓, 1,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↑, 5,   Ca+2↝, 3,   CAFs/TAFs↓, 1,   Cdc42↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 17,   EMT↓, 26,   EMT↝, 1,   FAK↓, 3,   FAK↑, 1,   p‑FAK↓, 1,   Fibronectin↓, 3,   ITGB1↓, 1,   KRAS↓, 1,   LAMs↓, 2,   LEF1↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 3,   MMP13↓, 1,   MMP16↓, 1,   MMP2↓, 26,   MMP2↑, 1,   MMP3↓, 5,   MMP7↓, 5,   MMP9↓, 32,   MMP9↑, 2,   MMPs↓, 13,   N-cadherin↓, 15,   Rac1↓, 1,   Rho↓, 1,   Rho↑, 1,   ROCK1↓, 3,   ROCK1↑, 1,   Slug↓, 5,   Smad1↓, 1,   Smad1↑, 2,   SMAD2↓, 1,   SMAD3↓, 2,   SMAD4↓, 1,   Snail↓, 13,   T-cadherin↑, 1,   TET1↓, 1,   TET1↑, 4,   TGF-β↓, 7,   TGF-β↑, 2,   TGF-β1↓, 1,   TIMP1↑, 1,   TIMP2↑, 2,   TSP-1↑, 1,   TumCI↓, 26,   TumCMig↓, 21,   TumMeta↓, 22,   Twist↓, 11,   Tyro3↓, 1,   uPA↓, 7,   Vim?, 1,   Vim↓, 17,   Vim↑, 1,   Zeb1↓, 4,   α-SMA↓, 1,   β-catenin/ZEB1↓, 21,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 24,   CD31/PECAM-1↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 22,   Hif1a↑, 1,   NO↓, 1,   NO↑, 1,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 34,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 3,   EPR↑, 1,   GLUT1↓, 4,   GLUT4↓, 2,   MMP↓, 24,   MMP↑, 1,   NHE1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 5,   CD47↓, 1,   CD8+↑, 5,   CLP↑, 1,   COX1↓, 3,   COX2/PTGS2↓, 25,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCL12↓, 1,   CXCR4↓, 6,   DR4↑, 2,   HMGB1↓, 1,   ICAM-1↓, 4,   IFN-γ↓, 4,   IL1↓, 1,   IL10↓, 1,   IL10↑, 1,   IL12↓, 2,   IL18↓, 1,   IL1β↓, 7,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 19,   IL8↓, 7,   Imm↑, 3,   Imm↝, 1,   Inflam↓, 14,   Inflam↑, 1,   M1↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   MCT1↓, 1,   NF-kB?, 1,   NF-kB↓, 59,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 2,   NLRP3↑, 3,   p50↓, 1,   p65↓, 2,   p‑p65↓, 2,   PD-1↓, 4,   PD-L1↓, 3,   PGE2↓, 10,   PSA↓, 3,   PSA∅, 1,   RAGE↓, 1,   TCF↓, 2,   Th1 response↑, 1,   TILs↑, 1,   TLR4↓, 2,   TNF-α↓, 13,   TNF-α↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   pH∅, 1,   e-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 6,   ER-α36↓, 2,   FGF21↓, 2,   GR↑, 1,   PPARα↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 15,   BioAv↝, 5,   BioEnh?, 1,   BioEnh↑, 1,   chemoR↓, 1,   ChemoSen↓, 1,   ChemoSen↑, 64,   CYP1A1↓, 2,   CYP3A4↓, 2,   Dose↓, 1,   Dose↑, 2,   Dose↝, 17,   Dose∅, 1,   eff↓, 9,   eff↑, 38,   eff⇅, 1,   eff↝, 5,   GSTA1↓, 1,   GSTM1↑, 1,   Half-Life↝, 5,   MDR1↓, 4,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 7,   P-gp/ABCB1↑, 1,   P450↓, 1,   RadioS↑, 20,   selectivity↑, 26,   selectivity∅, 1,   Synergy↑, 37,   TET2↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 6,   AST↓, 1,   BG↓, 1,   BP↓, 1,   CEA↓, 1,   CRP↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 14,   EGFR↑, 1,   EZH2↓, 3,   Ferritin↓, 1,   Ferritin↑, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 4,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 19,   KRAS↓, 1,   LDH↓, 3,   Myc↓, 2,   NSE↓, 1,   PD-L1↓, 3,   PSA↓, 3,   PSA∅, 1,   RAGE↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 11,   AntiTum↑, 8,   Appetite↑, 1,   cachexia↓, 1,   cardioP↑, 6,   CardioT↑, 1,   chemoP↑, 17,   chemoPv↑, 2,   ChemoSideEff↓, 4,   cognitive↑, 3,   hepatoP↓, 1,   hepatoP↑, 3,   memory↑, 1,   neuroP↑, 8,   NP/CIPN↓, 2,   OS↑, 4,   Pain↓, 1,   PFS↑, 1,   QoL↑, 4,   radioP↑, 7,   RenoP↑, 5,   Risk↓, 3,   Sleep↑, 1,   toxicity↓, 6,   toxicity↑, 2,   toxicity↝, 4,   toxicity∅, 1,   TumVol↓, 5,   TumW↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 4,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 716

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 119,   ARE↓, 1,   ARE↑, 8,   Bil↑, 2,   Catalase↑, 81,   DUOX1↓, 1,   Fenton↓, 3,   GCLC↑, 5,   GCLC↝, 1,   GCLM↑, 4,   GCLM↝, 1,   GPx↓, 1,   GPx↑, 54,   GPx1↑, 1,   GPx4↓, 2,   GPx4↑, 6,   GPx4∅, 1,   GSH↓, 2,   GSH↑, 90,   GSH/GSSG↑, 1,   GSR↓, 1,   GSR↑, 9,   GSS↑, 1,   GSSG↓, 1,   GSTs↓, 2,   GSTs↑, 14,   H2O2↓, 5,   H2O2↑, 1,   HDL↓, 1,   HDL↑, 1,   HNE↓, 2,   HNE↑, 1,   HO-1?, 2,   HO-1↓, 9,   HO-1↑, 237,   HO-1⇅, 1,   HO-1↝, 1,   HO-1∅, 1,   HO-2↓, 1,   hyperG↝, 1,   Iron↓, 3,   Iron↝, 1,   i-Iron↓, 1,   Keap1↓, 12,   Keap1↑, 1,   Keap1↝, 2,   lipid-P↓, 56,   lipid-P↑, 3,   mt-lipid-P↓, 1,   MDA↓, 84,   MDA↑, 1,   MPO↓, 12,   MPO↑, 1,   NOX↓, 2,   NOX1↓, 1,   NOX2↓, 2,   NOX4↓, 7,   NQO1↑, 47,   NQO1↝, 2,   Nrf1↑, 3,   NRF2↓, 7,   NRF2↑, 216,   NRF2∅, 1,   p‑NRF2↑, 1,   ONOO↓, 1,   Prx↑, 4,   RNS↓, 2,   ROS?, 1,   ROS↓, 201,   ROS↑, 4,   ROS⇅, 2,   ROS∅, 1,   mt-ROS?, 1,   mt-ROS↓, 2,   SOD↓, 2,   SOD↑, 120,   SOD1↑, 7,   SOD2↑, 5,   TAC↑, 13,   TBARS↓, 4,   Thiols↑, 1,   TOS↓, 1,   Trx↑, 3,   Trx1↑, 6,   TrxR↑, 2,   TrxR1↑, 1,   UCPs↑, 1,   uricA↓, 1,   VitC↑, 5,   VitE↓, 1,   VitE↑, 4,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↓, 1,   FTH1↑, 1,   IronCh↑, 10,   Mets↝, 1,   NCOA4↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   Insulin↑, 1,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 9,   mtDam↑, 1,   NGB↑, 1,   OCR↑, 1,   PDH↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 5,   PGC-1α↝, 2,   PINK1↓, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   3MST/MPST↑, 1,   5LO↓, 3,   ACC↓, 1,   ACSL4↓, 1,   ACSL4∅, 1,   ALAT↓, 18,   AMPK↑, 17,   p‑AMPK↑, 1,   ATP↑, 10,   Buty↑, 1,   cAMP↑, 1,   CBS↑, 1,   CRM↑, 2,   cytoP450↓, 1,   FABP4↓, 1,   FASN↓, 1,   G6PD↑, 1,   GAPDH↑, 1,   glucose↓, 5,   glucose↝, 1,   GlucoseCon↑, 6,   GlutMet↑, 1,   Glycolysis↑, 3,   GSK‐3β↓, 16,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 4,   H2S↑, 2,   HK1↑, 1,   HK2↑, 1,   HMG-CoA↓, 1,   LDHA↓, 1,   LDL↓, 6,   NAD↑, 1,   NADH:NAD↑, 1,   NADPH↓, 9,   NADPH↑, 10,   PDKs↓, 1,   PFK↓, 1,   PFK↑, 1,   PKM2↓, 2,   PKM2↑, 1,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 25,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   Apoptosis↓, 31,   ASC?, 1,   ASC↓, 1,   ASK1↓, 1,   BAX↓, 15,   BAX↑, 2,   Bax:Bcl2↓, 7,   Bcl-2↓, 1,   Bcl-2↑, 17,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp↓, 2,   Casp1↓, 4,   proCasp1↓, 1,   Casp12↓, 2,   Casp3?, 1,   Casp3↓, 27,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 5,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 7,   Casp9↑, 1,   Casp9∅, 1,   Cyt‑c↓, 5,   Cyt‑c∅, 3,   Fas↓, 1,   Ferroptosis↓, 12,   Ferroptosis↑, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 39,   iNOS↑, 2,   necrosis↓, 2,   p38↓, 5,   p‑p38↓, 3,   Pyro?, 1,   Pyro↓, 1,   RIP1↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 6,   Akt↑, 19,   p‑Akt↓, 1,   p‑Akt↑, 4,   e-Akt↑, 1,   AMPKα↑, 2,   CREB↑, 4,   p‑CREB↑, 2,   ERK↓, 10,   ERK↑, 9,   p‑ERK↓, 2,   p‑ERK↑, 3,   e-ERK↑, 1,   HGF/c-Met↑, 1,   IKKα↓, 2,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB?, 1,   IκB↓, 1,   IκB↑, 2,   JAK↓, 1,   JAK2↓, 1,   JAK2↑, 1,   JNK↓, 8,   p‑JNK↓, 5,   p‑JNK↑, 1,   LPAR1/EDG2↑, 1,   MAPK?, 1,   MAPK↓, 23,   p‑MAPK?, 1,   p‑MAPK↓, 2,   MEK↓, 1,   mTOR↓, 5,   mTOR↑, 1,   p‑mTOR↓, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 3,   PI3K↑, 14,   p‑PI3K↑, 1,   PKA↑, 2,   PKCδ↓, 2,   PKCδ↑, 1,   PP2A↑, 2,   PTEN↓, 1,   STAT↓, 1,   STAT3↓, 6,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF2↑, 1,   ATF4↓, 3,   ATF4↑, 1,   cJun↓, 1,   p‑cJun↓, 2,   p‑cMyc↑, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXO↑, 1,   FOXO3↑, 2,   HDAC↓, 2,   HDAC↑, 1,   miR-34a↓, 1,   other?, 1,   other↓, 3,   other↑, 6,   other↝, 5,   SOX2↑, 1,   tumCV↓, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 8,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 7,   GRP78/BiP↓, 5,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 5,   HSP70/HSPA5↝, 1,   HSPs↑, 1,   HSPs↝, 1,   PERK↓, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↓, 1,   autophagy↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3II↓, 1,   LC3II↑, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 2,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 10,   PARP↓, 1,   PARP∅, 1,   PARP1↓, 1,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 2,   Ki-67↓, 1,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   cFos↓, 1,   Choline↑, 1,   Diff↑, 1,   Diff↝, 1,   FGF↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 1,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 3,   NOTCH1↑, 1,   p300↓, 1,   TumCP↓, 2,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 6,   AP-1↓, 3,   mt-ATPase↑, 1,   Ca+2↓, 9,   Ca+2↑, 1,   i-Ca+2↓, 1,   Cartilage↑, 1,   COL1↓, 1,   EMT↑, 1,   Fibrosis↓, 1,   heparanase↑, 1,   LRP1↑, 1,   MMP1↓, 1,   MMP2↓, 2,   MMP2↑, 2,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 8,   MMP9↑, 1,   MUC1↑, 1,   Na+↑, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   TGF-β↓, 5,   TGF-β↑, 2,   TGF-β1↓, 2,   TGF-β1↑, 1,   TIMP1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TXNIP↓, 3,   uPA↑, 1,   α-SMA↓, 2,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 3,   Endoglin↑, 1,   eNOS↑, 1,   p‑eNOS↑, 2,   Hif1a↓, 2,   Hif1a↑, 2,   LOX1↓, 1,   NO↓, 24,   NO↑, 2,   TXA2↓, 1,   VCAM-1↓, 10,   VEGF↓, 4,   VEGF↑, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 23,   BBB↝, 1,   GLUT2↑, 2,   GLUT3↑, 4,   GLUT4↑, 6,   H+/K+-ATPase↓, 1,   IBI↑, 4,   memfluid↑, 1,   MMP↓, 3,   MMP↑, 15,   Na+↑, 1,   NHE3↑, 1,   OCLN↑, 1,   TJ↑, 1,   TRPA1↑, 1,   TRPC1↓, 1,   TRPV1↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 2,   CD25+↑, 1,   CD4+↑, 2,   COX1↓, 2,   COX2/PTGS2↓, 54,   COX2/PTGS2↑, 2,   CXCc↓, 1,   FOXP3↑, 2,   HMGB1↓, 5,   ICAM-1↓, 10,   IFN-γ↓, 8,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 7,   IL10↑, 13,   IL12↓, 3,   IL17↓, 7,   IL18↓, 4,   IL1β↓, 75,   IL2↓, 5,   IL22↓, 1,   IL23↓, 3,   IL33↓, 2,   IL4↓, 3,   IL4↑, 5,   IL6↓, 73,   IL6↑, 3,   IL8↓, 9,   Imm↑, 4,   Imm↝, 1,   Inflam?, 2,   Inflam↓, 145,   Inflam↑, 2,   LPS↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 8,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 2,   MyD88↓, 2,   NeuroI↓, 3,   NF-kB↓, 97,   NF-kB↑, 3,   NLRP3↓, 29,   NLRP3↑, 1,   NOD1↓, 1,   p65↓, 5,   PGE2↓, 16,   RAGE↓, 3,   RANTES↓, 1,   TLR1↓, 1,   TLR2↓, 2,   TLR3↓, 1,   TLR4↓, 19,   TLR4↑, 1,   TLR4∅, 1,   TNF-α↓, 98,   TNF-α↑, 1,   TRAF6↓, 1,   Treg lymp↝, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 6,   Ach↑, 4,   AChE↓, 34,   AChE∅, 1,   BChE↓, 7,   BChE∅, 1,   BDNF↑, 30,   BrainVol↑, 1,   ChAT↑, 6,   ChE↓, 1,   GABA↑, 2,   GDNF↑, 1,   MAOA↓, 4,   MAOB↓, 2,   NGF↑, 5,   PSD95↑, 4,   SYP↑, 1,   TPH1↓, 1,   TrkB↑, 5,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 5,   Aβ↓, 41,   BACE/β-secretase↓, 15,   tau↓, 11,   p‑tau↓, 11,   XO↓, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   END↑, 1,   ER(estro)↑, 1,   FGF21↑, 1,   GLP-1R↑, 1,   GR↑, 2,   NR1H4↑, 1,   PPARα↑, 4,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 14,   p‑PPARγ↓, 1,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 28,   BioAv↑, 36,   BioAv↝, 21,   ChemoSen↑, 3,   CompStab↑, 1,   CYP2D6↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 21,   eff↓, 2,   eff↑, 22,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 4,   Half-Life↓, 5,   Half-Life↑, 3,   Half-Life↝, 9,   MRP↓, 1,   P-gp/ABCB1↓, 1,   P450↑, 2,   selectivity↑, 2,   Synergy↑, 16,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 18,   ALB↑, 1,   ALP↓, 3,   AST↓, 19,   BG↓, 1,   Bil↑, 2,   BloodF↑, 2,   BMD↑, 2,   BP↓, 6,   BUN?, 1,   BUN↓, 4,   creat↓, 8,   CRP↓, 5,   Ferritin↑, 1,   IL6↓, 73,   IL6↑, 3,   IRes↝, 1,   LDH↓, 6,   LDH↑, 3,   NOS2↓, 4,   RAGE↓, 3,   SpO2↑, 1,   TMAO↓, 1,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 9,   antiAll↑, 10,   AntiArt↑, 3,   AntiCan↑, 11,   antiCG↑, 2,   AntiDiabetic↑, 12,   antiPs↑, 2,   AntiTum↑, 5,   ANXi↓, 1,   cardioP?, 2,   cardioP↑, 45,   CardioT↓, 2,   chemoP↑, 13,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 47,   diuretic↑, 2,   fatigue↓, 1,   GFR↑, 1,   hepatoP↓, 2,   hepatoP↑, 45,   Learn↑, 6,   memory↑, 51,   Mood↑, 1,   motorD↓, 1,   motorD↑, 5,   neuroP↑, 115,   NP/CIPN↓, 2,   Obesity↓, 9,   OS↑, 5,   Pain↓, 4,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 25,   Risk↓, 1,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 3,   Stress↓, 1,   Stroke↓, 11,   toxicity↓, 18,   toxicity↑, 2,   toxicity↝, 4,   toxicity∅, 3,   Weight↓, 1,   Weight↑, 1,   Weight∅, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 4,   AntiFungal↑, 5,   AntiViral↑, 7,   Bacteria↓, 10,   Diar↓, 3,   GutMicro↑, 21,   Sepsis↓, 7,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 619

Scientific Paper Hit Count for: HO-1, HMOX1
17 Curcumin
16 Luteolin
15 Resveratrol
15 Sulforaphane (mainly Broccoli)
15 Thymoquinone
11 Quercetin
9 Chemotherapy
9 Hydrogen Gas
9 Silymarin (Milk Thistle) silibinin
9 Shikonin
8 Ashwagandha(Withaferin A)
8 Fisetin
7 Ferulic acid
7 isoorientin
7 Lycopene
6 Cisplatin
6 Baicalein
6 Chlorogenic acid
6 Chrysin
6 Honokiol
6 Isoliquiritigenin
6 Morin
5 Alpha-Lipoic-Acid
5 diet FMD Fasting Mimicking Diet
5 EGCG (Epigallocatechin Gallate)
5 Hyperoside
5 Propolis -bee glue
4 doxorubicin
4 Berberine
4 Beta-Caryophyllene
4 Betulinic acid
4 Carnosic acid
4 Crocetin
4 Vitamin C (Ascorbic Acid)
4 Emodin
4 Piperlongumine
4 Pterostilbene
4 Rosmarinic acid
3 Artemisinin
3 Radiotherapy/Radiation
3 Berbamine
3 Boron
3 Boswellia (frankincense)
3 Capsaicin
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Celastrol
3 isoquercitrin
3 Isovitexin
3 Kaempferol
3 Matrine
3 Vitexin
2 Silver-NanoParticles
2 Selenite (Sodium)
2 Allicin (mainly Garlic)
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 methotrexate
2 Cinnamon
2 Copper and Cu NanoParticles
2 Ellagic acid
2 Gallic acid
2 Geraniol
2 Ginger/6-Shogaol/Gingerol
2 Licochalcone A
2 SDG/lignans
2 Linalool
2 Melatonin
2 5-fluorouracil
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Vitamin K2
1 1,8-Cineole
1 5-Aminolevulinic acid
1 chemodynamic therapy
1 Apigenin (mainly Parsley)
1 Astaxanthin
1 xanthohumol
1 Brucea javanica
1 brusatol
1 Bromelain
1 buckwheat sprouts
1 Caffeic acid
1 Carvacrol
1 Thymol-Thymus vulgaris
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chaetocin
1 Cucurbitacin
1 Cynaropicrin
1 diet Methionine-Restricted Diet
1 diet Short Term Fasting
1 Diindolylmethane
1 Indole-3-carbinol
1 Dipyridamole
1 Dandelion Root
1 Disulfiram
1 Eugenol
1 Formononetin
1 Fucoidan
1 Ginkgo biloba
1 Ginkgetin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Isobavachalcone
1 Juglone
1 Lactobacillus
1 lambertianic acid
1 Licorice
1 Lutein
1 Metformin
1 Magnetic Fields
1 Lemon Balm/Melissa officinalis
1 Zeolite
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Nimbolide
1 Oleuropein
1 Marjoram (Origanum majorana)
1 Propyl gallate
1 Phenolic Acids
1 Hydroxycinnamic-acid
1 Piperine
1 Polyphenols
1 salinomycin
1 Sanguinarine
1 Selenium
1 Oxygen, Hyperbaric
1 Sesame seeds and Oil
1 Spermidine
1 erastin
1 Taurine
1 Urolithin
1 Vanillic Acid
1 Mung Bean Sprouts
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:597  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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