TumMeta Cancer Research Results

TumMeta, Cancer Metastasis: Click to Expand ⟱
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Cancer metastasis is the process by which cancer cells spread from the original (primary) tumor to other parts of the body, forming new (secondary) tumors. This occurs when cancer cells invade surrounding tissues, enter the bloodstream or lymphatic system, and travel to distant organs or tissues.


Scientific Papers found: Click to Expand⟱
5187- PEITC,    Phenethyl Isothiocyanate Inhibits Migration and Invasion of Human Gastric Cancer AGS Cells through Suppressing MAPK and NF-κB Signal Pathways
- in-vitro, GC, AGS
TumMeta↓, ERK↓, MKK7↓, PKCδ↓, Rho↓, uPA↓, MMP2↓, MMP9↓, RAS↓, VEGF↓, FAK↓, iNOS↓, COX2/PTGS2↓, TumCP↓,
5209- PI,    Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP-9 signaling pathway in DU145 cells
- in-vitro, Pca, DU145
TumCP↓, TumCMig↓, Apoptosis↑, p‑Akt↓, MMP9↓, p‑mTOR↓, TumMeta↓, *antiOx↓, *Inflam↓, *hepatoP↑, *Imm↑, *AntiCan↑,
2973- PL,    The Natural Alkaloid Piperlongumine Inhibits Metastatic Activity and Epithelial-to-Mesenchymal Transition of Triple-Negative Mammary Carcinoma Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1
MMP2↓, MMP9↓, IL6↓, E-cadherin↑, ROS↑, EMT↓, Zeb1↓, Slug↓, TumMeta↓, selectivity↑, MMP2↓, GSH↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
1945- PL,  SANG,    The Synergistic Effect of Piperlongumine and Sanguinarine on the Non-Small Lung Cancer
- in-vitro, Lung, A549
toxicity∅, Apoptosis↑, TumMeta↓, ROS↑, TumCCA↑,
4967- PSO,    Psoralidin's Anti-Cancer Mechanisms: A Technical Guide
- Review, Var, NA
NF-kB↓, PI3K↓, Akt↓, ITGB1↓, FAK↓, BAX↑, Casp3↑, Apoptosis↑, Bcl-2↓, DR5↑, TumCCA↑, TumAuto↑, TumMeta↓,
1236- PTS,    Pterostilbene inhibits the metastasis of TNBC via suppression of β-catenin-mediated epithelial to mesenchymal transition and stemness
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
TumMeta↓, EMT↓, E-cadherin↑, Zeb1↓, Snail↓, β-catenin/ZEB1↓, CD44↓, MMPs↓, CSCs↓,
4697- PTS,    Pterostilbene and cancer: current review
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumMeta↑, toxicity↓, BioAv↑,
4694- PTS,    Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions
- Review, Var, NA
BioAv↑, AntiCan↑, Casp↑, TumCCA↑, angioG↓, TumMeta↓, MMP9↓, VEGF↓, CSCs↓, CD44↓, cMyc↓, ChemoSen↑, mTOR↓,
4692- PTS,    Pterostilbene Suppresses both Cancer Cells and Cancer Stem-Like Cells in Cervical Cancer with Superior Bioavailability to Resveratrol
- in-vitro, Cerv, HeLa
TumCG↓, TumMeta↓, TumCCA↑, ROS↑, Apoptosis↑, MMP2↓, MMP9↓, CD133↓, OCT4↓, SOX2↓, Nanog↓, STAT3↓, CSCs↓,
4690- PTS,  immuno,    Pterostilbene: Mechanisms of its action as oncostatic agent in cell models and in vivo studies
- Review, Var, NA
eff↑, Half-Life↑, TumCG↓, TumMeta↓, angioG↓, CSCs↓, Apoptosis↑, Synergy↑, CD44↓, CD24↓,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
3929- PTS,    New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects
- Review, Var, NA - Review, Arthritis, NA
*NRF2↑, *BioAv↑, *ROS↓, *Inflam↓, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *hepatoP↑, *neuroP↑, *iNOS↓, *COX2/PTGS2↓, TumMeta↓, SOD2↓, ROS↑, TumCI↓, TumCG↓, HDAC1↓, PTEN↑, BP↓, *GutMicro↑,
2341- QC,    Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
MMP2↓, MMP9↓, VEGF↓, Glycolysis↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, TumAuto↑, Akt↓, mTOR↓, TumMeta↓, MMP3↓, eff↓, GlucoseCon↓, lactateProd↓, TumAuto↑, LC3B-II↑,
1201- QC,    Quercetin: a silent retarder of fatty acid oxidation in breast cancer metastasis through steering of mitochondrial CPT1
- in-vivo, BC, NA
mitResp↓, Glycolysis↓, ATP↓, ROS↑, GSH↓, TumMeta↓, Apoptosis↑, FAO↓,
3353- QC,    Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
- in-vitro, Oral, KON - in-vitro, Nor, MRC-5
tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2/PTGS2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *Synergy↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, Synergy↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
3374- QC,    Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis
- Review, Oral, NA - Review, AD, NA
α-SMA↓, α-SMA↑, TumCP↓, tumCV↓, TumVol↓, TumCI↓, TumMeta↓, TumCMig↓, ROS↑, Apoptosis↑, BioAv↓, *neuroP↑, *antiOx↑, *Inflam↓, *Aβ↓, *cardioP↑, MMP↓, Cyt‑c↑, MMP2↓, MMP9↓, EMT↓, MMPs↓, Twist↓, Slug↓, Ca+2↑, AIF↑, Endon↑, P-gp/ABCB1↓, LDH↑, HK2↓, PKA↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, GRP78/BiP↑, Casp12↑, CHOP/DDIT3↑,
56- QC,    Quercetin inhibits epithelial–mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial–mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, PATU-8988
EMT↓, MMPs↓, MMP2↓, MMP7↓, STAT3↓, TumCI↓, TumMeta↓, tumCV↓,
80- QC,    Quercetin reverses EGF-induced epithelial to mesenchymal transition and invasiveness in prostate cancer (PC-3) cell line via EGFR/PI3K/Akt pathway
- in-vitro, Pca, PC3
Vim↓, ERK↓, Snail↓, Slug↓, Twist↓, EGFR↓, p‑Akt↓, EGFR↓, N-cadherin↓, TumMeta↓, EMT↓,
3083- RES,    Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
YAP/TEAD↓, Rho↓, FAK↓, MMP9↓, ChemoSen↑, RAS↓, ROCK1↓, TumCI↓, TumMeta↓,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2/PTGS2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, Synergy↑, Synergy↑, Synergy↑,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
101- RES,    Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis
- in-vitro, GC, SGC-7901
HH↓, Gli1↓, EMT↓, Snail↓, N-cadherin↓, E-cadherin↑, TumCI↓, TumMeta↓,
878- RES,    Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression
- vitro+vivo, CRC, LoVo
TumMeta↓, E-cadherin↑, Vim↓, TGF-β↓, SMAD2↓, EMT↓, SMAD3↓,
877- RES,    Resveratrol Inhibits Invasion and Metastasis of Colorectal Cancer Cells via MALAT1 Mediated Wnt/β-Catenin Signal Pathway
- in-vitro, CRC, LoVo - in-vitro, CRC, HCT116
MALAT1↓, Wnt/(β-catenin)↓, TumCI↓, TumMeta↓,
7150- RES,    Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
- Review, Var, NA
AntiTum↑, PI3K↓, Akt↓, *AntiAge↑, *SIRT1↑, *lipid-P↓, *ROS↓, *BioAv↓, *NRF2↑, *HO-1↑, SOD↑, HDAC1↓, PTEN↑, P53↑, TumCCA↑, TumCI↓, TumMeta↓, EMT↓, MMPs↓, MMP9↓, angioG↓, VEGF↓, EGFR↓, FGF21↓, HIF-1↓, *neuroP↑, *cardioP↑, BMPs↑, ROS↑, Vim↓, N-cadherin↓, MMP3↓, MMP13↓, E-cadherin↑, Ki-67↓,
3003- RosA,    Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, FOXM1↓, cycD1/CCND1↓, CDK4↓, MMP9↓, HDAC2↓,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp/ABCB1↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2/PTGS2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27/CDKN1B↑, CHOP/DDIT3↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
5035- SAS,    Sulfasalazine, a potent suppressor of gastric cancer proliferation and metastasis by inhibition of xCT: Conventional drug in new use
- Human, GC, NA - in-vitro, GC, NCI-N87 - in-vitro, GC, SGC-7901
other?, TumCP↓, TumMeta↓, TumCI↓, xCT/SLC7A11↓, OS↑,
6220- Se,  CUR,  Rad,    Selenium-Curcumin-PEG Nanoparticles Radiosensitization for Intensity-Modulated Radiation Therapy of Lung Tumor Cells: In Vitro Synergistic Combination Therapy
- in-vitro, Lung, A549
RadioS↑, TumCD↑, ROS↑, Imm↑, angioG↓, BioAv↑, TumCP↓, Apoptosis↓, TumMeta↓, CompStab↑,
4492- Se,    Selenium in cancer prevention: a review of the evidence and mechanism of action
- Review, Var, NA
Risk↓, AntiCan↑, *selenoP↑, TumMeta↓, *DNAdam↓, OS↑, *ROS↓,
4603- SeNPs,    Therapeutic applications of selenium nanoparticles
- Review, Var, NA
AntiCan↑, Imm↑, *AntiDiabetic↑, *antiOx↑, *Inflam↓, ROS↑, ER Stress↑, DNAdam↑, *toxicity↓, *eff↑, *BioAv↑, selectivity↑, TumCCA↑, Risk↓, *lipid-P↓, *TNF-α↓, *CRP↓, TumMeta↓, angioG↓, selectivity↑, Synergy↑, *Synergy↑,
4469- SeNPs,    Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential
- Review, Var, NA
antiOx↑, selectivity↑, eff↑, AntiCan↑, Apoptosis↑, ROS↑, MMP↓, Casp3↑, Casp9↑, AntiTum↑, TumCG↓, TumMeta↓, angioG↓, Cyt‑c↑, DNAdam↑, RadioS↑, BBB↑, *toxicity↓, ChemoSen↑,
3188- SFN,    Sulforaphane inhibited tumor necrosis factor-α induced migration and invasion in estrogen receptor negative human breast cancer cells
- in-vitro, BC, NA
TNF-α↓, TumCI↓, TumMeta↓, MMPs↓, MMP2↓, MMP9↓, MMP13↓,
3182- SFN,    Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells
- in-vitro, AML, NA
Prx↓, AQPs↓, NOX↓, tumCV↓, AntiCan↑, cardioP↑, neuroP↑, Inflam↓, chemoPv↑, angioG↓, TumMeta↓, selectivity↑, ROS↓,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2/PTGS2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,
1484- SFN,    Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action
- Review, Var, NA - Review, AD, NA
neuroP↑, AntiCan↑, NRF2↑, HDAC↓, eff↑, *ROS↓, neuroP↑, HDAC↓, *toxicity∅, BioAv↑, eff↓, cycD1/CCND1↓, CDK4↓, p‑RB1↓, Glycolysis↓, miR-30a-5p↑, TumCCA↑, TumCG↓, TumMeta↓, eff↑, ChemoSen↑, RadioS↑, CardioT↓, angioG↓, Hif1a↓, VEGF↓, *BioAv?, *Half-Life∅,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, Synergy↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
3323- SIL,    Anticancer therapeutic potential of silibinin: current trends, scope and relevance
- Review, Var, NA
Inflam↓, angioG↓, antiOx↑, TumMeta↓, TumCP↓, TumCCA↑, TumCD↑, α-SMA↓, p‑Akt↓, p‑STAT3↓, COX2/PTGS2↓, IL6↓, MMP2↓, HIF-1↓, Snail↓, Slug↓, Zeb1↓, NF-kB↓, p‑EGFR↓, JAK2↓, PI3K↓, PD-L1↓, VEGF↓, CDK4↓, CDK2↓, cycD1/CCND1↓, E2Fs↓,
3041- SK,    Promising Nanomedicines of Shikonin for Cancer Therapy
- Review, Var, NA
Glycolysis↓, TAMS↝, BioAv↓, Half-Life↝, P21↑, ERK↓, ROS↑, GSH↓, MMP↓, TrxR↓, MMP13↓, MMP2↓, MMP9↓, SIRT2↑, Hif1a↓, PKM2↓, TumCP↓, TumMeta↓, TumCI↓,
4742- SSE,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
5337- TFdiG,    Theaflavin 3,3'-digallate suppresses metastasis and reduces insulin-like growth factor-1-induced cancer stemness and invasiveness in human melanoma cells
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, A2058
TumCMig↓, TumCI↓, MMPs↓, ALDH↓, CSCs↓, ABCG2↓, CD44↓, CXCR4↓, TumCG↓, angioG↓, TumMeta↓,
1138- TQ,    Thymoquinone inhibits epithelial-mesenchymal transition in prostate cancer cells by negatively regulating the TGF-β/Smad2/3 signaling pathway
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumMeta↓, EMT↓, E-cadherin↑, Vim↓, Slug↓, TGF-β↓, SMAD2↓, SMAD3↓,
1930- TQ,    Therapeutic implications and clinical manifestations of thymoquinone
- Review, Var, NA
AntiCan↑, antiOx↑, Inflam↓, TumCP↓, TumCCA↑, Apoptosis↑, ROS↑, TumMeta↓, TumCI↓,

Showing Research Papers: 301 to 350 of 372
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 372

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 16,   antiOx⇅, 1,   Catalase↑, 3,   Fenton↑, 2,   GPx↑, 3,   GPx1↓, 1,   GPx4↓, 5,   GSH↓, 20,   GSH↑, 4,   GSH/GSSG↓, 1,   GSR↓, 2,   GSR↑, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 3,   HO-1↑, 9,   Iron↑, 2,   lipid-P↓, 2,   lipid-P↑, 9,   MDA↓, 2,   MDA↑, 5,   NADH↓, 1,   NOX↓, 1,   NQO1↑, 1,   NRF2↓, 12,   NRF2↑, 10,   NRF2↝, 1,   Prx↓, 2,   Prx4↑, 1,   ox-PrxI↑, 1,   PrxII↓, 1,   RNS↑, 1,   ROS↓, 17,   ROS↑, 141,   ROS⇅, 4,   ROS↝, 1,   i-ROS↓, 1,   mt-ROS↑, 2,   SOD↓, 1,   SOD↑, 6,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 3,   Thiols↓, 1,   Trx↓, 1,   TrxR↓, 6,   TrxR1↓, 1,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR-ABL↓, 1,   CDC25↓, 4,   compI↓, 1,   EGF↓, 1,   ETC↓, 5,   mitResp↓, 3,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↑, 9,   OCR↓, 5,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,   PDH↝, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 2,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 2,   ACC↑, 1,   ALAT↓, 3,   AMPK?, 1,   AMPK↓, 1,   AMPK↑, 14,   p‑AMPK↑, 1,   ATP↓, 14,   ATP↑, 1,   mt-ATP↓, 1,   Buty↑, 1,   CAIX/CA9↑, 1,   ECAR↓, 3,   ENO1↓, 1,   FAO↓, 1,   FASN↓, 5,   G6PD↓, 3,   GAPDH↓, 1,   GLS↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 12,   GlutMet↓, 1,   Glycolysis↓, 31,   GSK‐3β↓, 11,   GSK‐3β↑, 1,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 2,   Histones↑, 1,   HK2↓, 13,   HMG-CoA↓, 1,   lactateProd↓, 10,   lactateProd↑, 1,   LDHA↓, 6,   LDL↓, 3,   NADPH↓, 3,   NADPH↑, 1,   PA↑, 1,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PFK↓, 1,   PFK1↓, 1,   PKM2↓, 10,   PPP↓, 1,   Pyruv↓, 1,   SCD1↓, 1,   SCFAs↑, 1,   SIRT1↓, 5,   SIRT1↑, 8,   SIRT2↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 7,   Apoptosis↑, 154,   m-Apoptosis↑, 1,   mt-Apoptosis↑, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 3,   BAD↑, 2,   Bak↑, 4,   BAX↓, 1,   BAX↑, 57,   Bax:Bcl2↑, 11,   Bcl-2↓, 65,   Bcl-2↑, 4,   Bcl-xL↓, 18,   BID↓, 1,   BID↑, 3,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 6,   BNIP3↑, 1,   Casp↓, 1,   Casp↑, 24,   Casp↝, 1,   Casp∅, 1,   cl‑Casp↑, 1,   Casp1↓, 2,   Casp1↑, 1,   Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 76,   cl‑Casp3↑, 7,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 13,   cl‑Casp7↑, 2,   Casp8↑, 11,   cl‑Casp8↑, 2,   proCasp8↑, 1,   Casp9↑, 44,   cl‑Casp9↑, 3,   proCasp9↑, 1,   cFLIP↓, 2,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 46,   Cyt‑c↝, 1,   Diablo↑, 6,   DR5↑, 10,   Endon↑, 1,   FADD↑, 5,   Fas↓, 1,   Fas↑, 10,   FasL↑, 4,   Ferroptosis↑, 11,   GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 5,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   ICD↑, 1,   iNOS↓, 8,   Mcl-1↓, 14,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 6,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↑, 1,   Necroptosis↑, 1,   necrosis↑, 2,   NOXA↑, 1,   p38↓, 4,   p38↑, 11,   p‑p38↓, 3,   p‑p38↑, 2,   Paraptosis↑, 1,   PUMA↑, 2,   Pyro↑, 3,   survivin↓, 37,   TRAIL↑, 1,   TumCD↓, 1,   TumCD↑, 14,   TumCD∅, 1,   XIAP↓, 13,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 111,   Akt↑, 1,   p‑Akt↓, 16,   p‑Akt↑, 1,   AKT1↓, 3,   Akt2↓, 1,   BRAF↓, 1,   CaMKII ↑, 1,   CIP2A↓, 1,   CK2↓, 3,   cMET↓, 2,   CREB↓, 1,   CREB↑, 1,   cSrc↓, 2,   DDIT4↑, 1,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 27,   p‑EGFR↓, 1,   ERK↓, 30,   ERK↑, 4,   ERK↝, 1,   p‑ERK↓, 8,   p‑ERK↑, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↝, 1,   IGF-1R↓, 4,   IGFR↓, 1,   IKKα↓, 5,   IP6K1↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 4,   JAK1↓, 3,   JAK2↓, 8,   JNK↓, 4,   JNK↑, 13,   p‑JNK↓, 3,   p‑JNK↑, 2,   MAPK?, 1,   MAPK↓, 34,   MAPK↑, 7,   MARK4↓, 1,   MEK↓, 3,   mTOR↓, 51,   mTOR↑, 1,   p‑mTOR↓, 3,   mTORC2↓, 1,   p42↑, 1,   P70S6K↓, 3,   PI3K↓, 79,   p‑PI3K↓, 2,   PKA↓, 1,   PKCδ↓, 7,   PTEN↓, 1,   PTEN↑, 17,   p‑PTEN↓, 1,   Raf↓, 2,   c-Raf↓, 1,   RAS↓, 6,   SHP1↑, 2,   Sp1/3/4↓, 10,   Src↓, 2,   STAT↓, 4,   STAT3↓, 51,   STAT3↑, 1,   STAT3↝, 1,   p‑STAT3↓, 7,   STAT5↓, 2,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↓, 1,   ATF4↑, 4,   ATF4↝, 1,   CBP↓, 3,   ChrMod↑, 1,   circNAV3↓, 1,   cJun↓, 3,   cJun↑, 2,   cMyc↓, 23,   cMyc↑, 1,   DNMT1↓, 5,   DNMT3A↓, 2,   DNMTs↓, 5,   EZH2↓, 2,   FOXM1↓, 2,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 3,   FOXO3↑, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   GATA2↑, 1,   H3↑, 1,   ac‑H3↑, 2,   H4↑, 2,   ac‑H4↑, 2,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 16,   HDAC1↓, 5,   HDAC2↓, 2,   HDAC4↓, 3,   HDAC8↓, 1,   HES1↓, 1,   miR-106b↓, 1,   miR-107↑, 1,   miR-125b↝, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 1,   miR-200b↑, 1,   miR-205↑, 1,   miR-21↓, 4,   miR-218↑, 1,   miR-224↓, 1,   miR-29b↑, 2,   miR-30a-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-422a↑, 1,   miR-590-3p↑, 1,   Myc↓, 4,   NDRG1↑, 2,   OCT4↓, 9,   other?, 3,   other↓, 1,   other↑, 8,   other↝, 12,   PCAF↓, 1,   SD↝, 1,   SOX2↓, 7,   SOX4↓, 1,   SOX4↑, 1,   TCF-4↓, 1,   TLE1↓, 1,   tumCV↓, 26,   tumCV∅, 1,   YMcells↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 11,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 2,   p‑eIF2α↑, 3,   ER Stress↓, 2,   ER Stress↑, 23,   GRP78/BiP↓, 2,   GRP78/BiP↑, 6,   HSF1↓, 1,   HSP27↓, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 3,   e-HSP70/HSPA5↓, 1,   HSP90↓, 8,   HSP90↑, 1,   HSPs↓, 1,   IRE1↑, 2,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 3,   LC3B-II↑, 1,   LC3II↑, 10,   LC3s↓, 1,   LC3s↑, 1,   p62↓, 4,   p62↑, 1,   PARK2↑, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 34,   TumAuto↝, 1,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   BRCA1↓, 2,   BRCA1↑, 2,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 38,   DNArepair↓, 2,   DNArepair↑, 1,   m-FAM72A↓, 1,   G9a↓, 1,   hTERT/TERT↓, 5,   P53?, 1,   P53↓, 2,   P53↑, 59,   P53↝, 2,   p‑P53↑, 3,   PARP↑, 5,   cl‑PARP↓, 1,   cl‑PARP↑, 38,   PARP1↑, 3,   PCNA↓, 20,   POLD1↓, 1,   SIRT6↓, 1,   Telomerase↓, 5,   TOP1↓, 5,   TOP2↓, 4,   TP53↑, 1,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 5,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK2↓, 21,   CDK2↑, 1,   CDK4↓, 29,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 9,   CDK6↑, 1,   CDK7↓, 1,   CHK1↓, 2,   CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 2,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 12,   cycD1/CCND1↓, 47,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 11,   E2Fs↓, 5,   E2Fs↑, 1,   GADD45A↓, 1,   Ki-67↓, 22,   Ki-67↑, 1,   MAD↓, 1,   mitA↑, 2,   P21?, 1,   P21↓, 3,   P21↑, 40,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 15,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 3,   RRM2↓, 1,   Securin↓, 1,   TubPol↓, 1,   TumCCA?, 1,   TumCCA↓, 8,   TumCCA↑, 132,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 8,   ALDH1A1↓, 1,   AXIN1↑, 1,   Axin2↑, 1,   BMI1↓, 1,   BMPs↑, 2,   CD133↓, 5,   CD133↑, 1,   CD24↓, 3,   CD34↓, 2,   cFos↓, 5,   cMYB↓, 1,   CSCs↓, 35,   CSCsMark↓, 1,   Diff↑, 4,   Gli1↓, 7,   HH↓, 7,   HMGCR↓, 1,   IGF-1↓, 5,   IGF-2↓, 1,   IGFBP3↑, 2,   Jun↓, 1,   Ki-67↓, 22,   Ki-67↑, 1,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 7,   Nestin↓, 1,   NOTCH↓, 9,   NOTCH1↓, 9,   NOTCH1↑, 2,   NOTCH1↝, 1,   NOTCH3↓, 2,   p300↓, 3,   Piezo1↑, 1,   PTCH1↓, 1,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 3,   Smo↓, 2,   STAT1↓, 1,   TumCG?, 1,   TumCG↓, 86,   TumCG↑, 4,   TumCG⇅, 1,   TumCG↝, 1,   TumCG∅, 2,   TumCP↓, 134,   TumCP↑, 4,   WDR72↓, 1,   Wnt↓, 29,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   annexin II↓, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 10,   AP-1↝, 1,   ASAP2↓, 1,   AXL↓, 2,   BACH1↑, 1,   Ca+2↓, 2,   Ca+2↑, 14,   CAFs/TAFs↓, 1,   cal2↑, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 1,   Cdc42↑, 1,   Cofilin↓, 1,   COL11A1↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 45,   EMT↓, 80,   EMT↑, 2,   EpCAM↓, 3,   F-actin↓, 2,   FAK↓, 15,   p‑FAK↓, 4,   p‑FAK↑, 1,   Fibronectin↓, 4,   GIT1↓, 1,   GLI2↓, 1,   ITGB1↓, 4,   ITGB4↓, 2,   ITGB6↓, 1,   LAMs↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MET↓, 1,   MMP1↓, 5,   MMP13↓, 5,   MMP15↓, 1,   MMP16↓, 1,   MMP2↓, 76,   MMP3↓, 6,   MMP7↓, 4,   MMP9↓, 96,   MMP9↑, 3,   MMPs↓, 40,   MUC4↓, 2,   N-cadherin↓, 29,   Na+↑, 1,   NEDD9↓, 1,   p44↑, 1,   PAK1↓, 1,   pax↓, 1,   PDGF↓, 4,   Rac1↓, 2,   RECK↑, 2,   Rho↓, 7,   ROCK1↓, 5,   Slug↓, 14,   SMAD2↓, 3,   SMAD3↓, 4,   SMAD4↓, 2,   Snail?, 1,   Snail↓, 27,   TET1↑, 2,   TGF-β↓, 16,   TGF-β↑, 2,   TIMP1↑, 8,   TIMP2↑, 9,   TIMP3↑, 1,   pol-TregCell↓, 1,   TRIB3↑, 2,   TSP-1↑, 2,   TumCA↓, 1,   TumCI?, 1,   TumCI↓, 117,   TumCI↑, 3,   TumCMig↓, 65,   TumCMig↑, 2,   TumMeta?, 1,   TumMeta↓, 355,   TumMeta↑, 20,   TumMeta∅, 1,   TumPF↓, 1,   Twist↓, 18,   TXNIP↑, 1,   uPA↓, 12,   uPAR↓, 2,   Vim?, 1,   Vim↓, 34,   Vim↑, 1,   Zeb1↓, 15,   ZEB2↓, 3,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↓, 40,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 125,   angioG↑, 5,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   ECM/TCF↓, 1,   eNOS↓, 1,   HIF-1↓, 5,   Hif1a↓, 41,   Hif1a↝, 1,   NO↓, 4,   TXA2↓, 2,   VCAM-1↓, 1,   VEGF↓, 76,   VEGFR1↓, 4,   VEGFR2/KDR/Flk1↓, 15,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 9,   CellMemb↑, 1,   CLDN1↓, 1,   CLDN1↑, 1,   CLDN2↓, 1,   EPR↑, 9,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↑, 1,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 59,   MPT↑, 2,   Na+↑, 1,   OCLN↑, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPM7↑, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 11,   CD8+↑, 6,   COX1↓, 5,   COX2/PTGS2↓, 52,   COX2/PTGS2↑, 1,   CXCL12↓, 1,   CXCL16↓, 1,   CXCR2↓, 2,   CXCR4↓, 13,   DCells↑, 1,   DR4↑, 5,   FOXP3↓, 1,   Gal-3↓, 2,   HMGB1↓, 2,   ICAM-1↓, 6,   IFN-γ↑, 1,   Igs↑, 1,   IL1↓, 4,   IL1↑, 1,   IL10↓, 3,   IL10↑, 1,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 4,   IL4↓, 2,   IL4↑, 1,   IL6↓, 33,   IL6↑, 1,   IL8↓, 9,   IL8↑, 1,   Imm↑, 23,   Imm↝, 3,   Inflam↓, 30,   Inflam↝, 1,   LRIG1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 4,   MCT1↓, 1,   MDSCs↓, 1,   mPGES-1↓, 1,   NF-kB?, 1,   NF-kB↓, 100,   NF-kB↑, 2,   NF-kB↝, 1,   p‑NF-kB↑, 1,   NK cell↑, 7,   NLRP3↓, 5,   NLRP3↑, 1,   p65↓, 4,   p‑p65↓, 2,   PD-1↓, 2,   PD-L1↓, 3,   PGE2↓, 14,   PSA↓, 6,   RAGE↓, 1,   T-Cell↑, 2,   TCF↓, 1,   TCF7/TCF1↓, 1,   Th1 response↑, 2,   TLR4↓, 2,   TLR4↝, 1,   TNF-α↓, 20,   TNF-α↑, 4,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   e-pH↑, 5,   TAMS↑, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AR↓, 7,   ERα/ESR1↓, 1,   FGF21↓, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 3,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 38,   BioAv↑, 40,   BioAv↝, 8,   BioEnh↑, 2,   ChemoSen?, 1,   ChemoSen↓, 2,   ChemoSen↑, 119,   ChemoSen∅, 1,   CompStab?, 1,   CompStab↓, 3,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 3,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   DDS↑, 4,   Dose?, 2,   Dose↓, 2,   Dose↑, 3,   Dose↝, 37,   Dose∅, 6,   DrugR↓, 1,   eff↓, 15,   eff↑, 73,   eff↝, 4,   eff∅, 2,   GSTA1↑, 1,   GSTP1/GSTπ↓, 1,   Half-Life↓, 12,   Half-Life↑, 3,   Half-Life↝, 8,   Half-Life∅, 1,   MDR1↓, 6,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 14,   P-gp/ABCB1↑, 1,   P-gp/ABCB1↝, 1,   P450↓, 2,   RadioS?, 1,   RadioS↑, 27,   selectivity?, 1,   selectivity↑, 45,   Synergy↑, 63,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 3,   ALP↓, 1,   AR↓, 7,   ascitic↓, 1,   AST↓, 2,   BP↓, 1,   BRAF↓, 1,   BRCA1↓, 2,   BRCA1↑, 2,   p‑BRCA1↑, 1,   CRP↓, 1,   CTC↓, 1,   EGFR↓, 27,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 2,   FOXM1↓, 2,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 5,   IL6↓, 33,   IL6↑, 1,   LDH↓, 2,   LDH↑, 2,   e-LDH↑, 1,   Maspin↑, 1,   Myc↓, 4,   NOS2↓, 1,   PD-L1↓, 3,   PSA↓, 6,   PSADT↓, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TP53↑, 1,   TRIB3↑, 2,   XIST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 39,   AntiCan∅, 1,   AntiDiabetic↑, 1,   antiNeop↑, 2,   AntiTum↑, 27,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 6,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 21,   chemoPv↑, 20,   ChemoSideEff↓, 3,   fatigue↓, 1,   FTO↓, 1,   hepatoP↓, 1,   hepatoP↑, 6,   kidSt↓, 1,   neuroP↑, 7,   OS↑, 20,   OS⇅, 1,   Pain↓, 3,   Pin1↓, 1,   QoL↑, 8,   radioP↑, 11,   Remission↑, 3,   RenoP↑, 3,   Risk↓, 21,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 14,   toxicity↑, 4,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 26,   TumVol∅, 1,   TumW↓, 7,   TumW∅, 1,   Weight↓, 1,   Weight↑, 2,   Weight∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 2,   GutMicro↑, 6,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 2,   Ingr↝, 3,  
Total Targets: 886

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 3,   antiOx↑, 51,   Catalase↑, 19,   GPx↑, 16,   GPx1↑, 2,   GSH↑, 12,   GSR↑, 4,   GSTs↑, 10,   H2O2↓, 1,   HDL↓, 1,   HO-1↑, 11,   hyperG↝, 1,   Iron∅, 1,   Keap1↓, 1,   lipid-P↓, 18,   MDA↓, 6,   NRF2↑, 20,   RNS↓, 2,   ROS?, 2,   ROS↓, 50,   selenoP↑, 1,   SOD↓, 1,   SOD↑, 19,   SOD1↑, 4,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 1,   VitC↑, 1,   VitE↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↓, 1,   AMPK↑, 4,   ATP↓, 1,   cytoP450↓, 1,   glucose↓, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 1,   LDL↓, 2,   lipidLev↓, 2,   NAD↓, 1,   NADPH↑, 1,   SIRT1↑, 2,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↓, 1,   Casp3↓, 1,   cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 8,   p38↓, 1,   RIP1↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt2↓, 1,   CREB↑, 1,   ERK↑, 1,   IKKα↓, 1,   p‑JNK↓, 1,   MAPK↓, 4,   mTOR↓, 1,   PI3K↓, 1,   PKCδ↓, 2,   STAT↓, 1,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   other↓, 2,   other↝, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   HSP70/HSPA5↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   P53↓, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   GADD34↓, 1,   P21↓, 2,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↑, 1,   neuroG↑, 1,   TumCG↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 7,   AP-1↓, 2,   Ca+2↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 1,   MMP9↓, 1,   TGF-β↓, 1,   TumMeta↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 5,   TXA2↓, 1,   VCAM-1↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   GastroP↑, 3,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   MMP↓, 1,   MMP↑, 1,   MMP∅, 1,   OCLN↝, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 13,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 1,   IL17↓, 2,   IL1β↓, 9,   IL2↓, 1,   IL23↓, 1,   IL6?, 1,   IL6↓, 11,   Imm↓, 1,   Imm↑, 5,   Imm⇅, 1,   Inflam?, 1,   Inflam↓, 54,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB?, 1,   NF-kB↓, 15,   NLRP3↓, 3,   PGE2↓, 6,   TLR4↓, 1,   TLR4↑, 1,   TNF-α?, 1,   TNF-α↓, 13,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 6,   AChE↝, 1,   BDNF↓, 1,   BDNF↑, 1,   GABA↑, 2,   MAOA↓, 1,   NGF↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   Estro↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 17,   BioAv↑, 23,   BioAv↝, 6,   BioEnh↑, 1,   CompStab↑, 2,   Dose?, 1,   Dose↝, 4,   eff↑, 3,   GSTA1↑, 2,   Half-Life↓, 3,   Half-Life↝, 2,   Half-Life∅, 1,   P450↑, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 3,   AST↓, 4,   BG↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 1,   CRP↓, 4,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 11,   IRes↑, 1,   LDH↓, 2,   TC↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 5,   antiAll↑, 2,   AntiArt↑, 4,   AntiCan↑, 12,   antiCG↑, 1,   AntiDiabetic↑, 13,   AntiTum↑, 3,   Bone Healing↑, 1,   cardioP↑, 23,   chemoP↑, 4,   cognitive↓, 1,   cognitive↑, 8,   cough?, 1,   hepatoP↑, 18,   memory↑, 8,   Mood↑, 1,   motorD↓, 1,   neuroP↑, 33,   Obesity↓, 4,   OS↑, 1,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 1,   SoreThr?, 1,   Stroke↓, 2,   toxicity↓, 19,   toxicity↑, 1,   toxicity↝, 6,   toxicity∅, 4,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6,   AntiFungal↑, 3,   AntiP↑, 1,   AntiViral↑, 6,   Bacteria↓, 9,   GutMicro↑, 9,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr↑, 3,   Ingr↝, 8,   Phen↑, 1,   QC↑, 1,  
Total Targets: 231

Scientific Paper Hit Count for: TumMeta, Cancer Metastasis
15 Curcumin
11 Thymoquinone
9 Nimbolide
8 Resveratrol
8 Eugenol
8 Quercetin
7 Melatonin
7 Pterostilbene
6 Chrysin
6 Magnetic Fields
6 Bicarbonate(Sodium)
5 Artemisinin
5 Aspirin
5 chitosan
5 Fisetin
5 Fucoidan
5 Gambogic Acid
5 Honokiol
5 phytic acid, Inositol hexakisphosphate
5 Kaempferol
5 Luteolin
5 Phenethyl isothiocyanate
4 Silver-NanoParticles
4 brusatol
4 Capsaicin
4 Celastrol
4 Flaxseed/Linseed
4 Inositol
4 Ivermectin
4 Magnetic Field Rotating
4 Marjoram (Origanum majorana)
4 Piperlongumine
4 Sulforaphane (mainly Broccoli)
4 Silymarin (Milk Thistle) silibinin
3 Baicalein
3 Berbamine
3 Biochanin A
3 Beta-Caryophyllene
3 Propolis -bee glue
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Chlorogenic acid
3 Cinnamon
3 Copper and Cu NanoParticles
3 Disulfiram
3 immunotherapy
3 EGCG (Epigallocatechin Gallate)
3 Garcinol
3 Ginkgetin
3 Licorice
3 Matrine
3 mebendazole
3 Modified Citrus Pectin
3 Ursolic acid
3 Vitamin C (Ascorbic Acid)
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 Isovitexin
2 Ashwagandha(Withaferin A)
2 Ascorbyl Palmitate
2 Astaxanthin
2 Betulinic acid
2 Brucea javanica
2 Bromelain
2 Boswellia (frankincense)
2 Bruteridin(bergamot juice)
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Zinc
2 Coenzyme Q10
2 Vitamin K2
2 Cucurbitacin
2 Cyclopamine
2 Deguelin
2 D-limonene
2 Ellagic acid
2 Emodin
2 Sorafenib (brand name Nexavar)
2 Formononetin
2 Gallic acid
2 Ginkgo biloba
2 Isoliquiritigenin
2 isoorientin
2 Juglone
2 Licochalcone A
2 Lycopene
2 Magnolol
2 Radiotherapy/Radiation
2 Rosmarinic acid
2 Selenium
2 Selenium NanoParticles
2 Urolithin
1 1,8-Cineole
1 3-bromopyruvate
1 Astragalus
1 Ajoene (compound of Garlic)
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 almonertinib
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Atorvastatin
1 beta-glucans
1 Berberine
1 Bufalin/Huachansu
1 borneol
1 Butyrate
1 Carnosic acid
1 Caffeic acid
1 urea
1 Cannabidiol
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorophyllin
1 Docetaxel
1 Chocolate
1 Metformin
1 Boron
1 Carica papaya leaf extract
1 Crocetin
1 Dasatinib/Phyrago
1 Diclofenac
1 Date Fruit Extract
1 Docosahexaenoic Acid
1 Dipyridamole
1 Ginkgo biloba-EGb 761
1 Electrical Pulses
1 Ferulic acid
1 ferumoxytol
1 Flaxseed Oil
1 Shilajit/Fulvic Acid
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Inulin Prebiotic
1 capecitabine
1 Gemcitabine (Gemzar)
1 isoflavones
1 isoquercitrin
1 itraconazole
1 Vitexin
1 Lapachol
1 VitK3,menadione
1 Lasiodin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Lutein
1 MCT oil
1 Magnesium
1 Moringa oleifera
1 Methylsulfonylmethane
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 nicotinamide adenine dinucleotide
1 Dichloroacetate
1 Oleuropein
1 Aromatherapy
1 Phenylbutyrate
1 Piperine
1 Sanguinarine
1 Psoralidin
1 salinomycin
1 Sulfasalazine
1 Shikonin
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Vitamin D3
1 Whole Body Vibration
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:604  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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