Cyt‑c Cancer Research Results

Cyt‑c, cyt-c Release into Cytosol: Click to Expand ⟱
Source:
Type:
Cytochrome c
** The term "release of cytochrome c" ** an increase in level for the cytosol.
Small hemeprotein found loosely associated with the inner membrane of the mitochondrion where it plays a critical role in cellular respiration. Cytochrome c is highly water-soluble, unlike other cytochromes. It is capable of undergoing oxidation and reduction as its iron atom converts between the ferrous and ferric forms, but does not bind oxygen. It also plays a major role in cell apoptosis.

The term "release of cytochrome c" refers to a critical step in the process of programmed cell death, also known as apoptosis.
In its new location—the cytosol—cytochrome c participates in the apoptotic signaling pathway by helping to form the apoptosome, which activates caspases that execute cell death.
Cytochrome c is a small protein normally located in the mitochondrial intermembrane space. Its primary role in healthy cells is to participate in the electron transport chain, a process that helps produce energy (ATP) through oxidative phosphorylation.
Mitochondrial outer membrane permeability leads to the release of cytochrome c from the mitochondria into the cytosol.
The release of cytochrome c is a pivotal event in apoptosis where cytochrome c moves from the mitochondria to the cytosol, initiating a chain reaction that leads to programmed cell death.

On the one hand, cytochrome c can promote cancer cell survival and proliferation by regulating the activity of various signaling pathways, such as the PI3K/AKT pathway. This can lead to increased cell growth and resistance to apoptosis, which are hallmarks of cancer.
On the other hand, cytochrome c can also induce apoptosis in cancer cells by interacting with other proteins, such as Apaf-1 and caspase-9. This can lead to the activation of the intrinsic apoptotic pathway, which can result in the death of cancer cells.
Overexpressed in Breast, Lung, Colon, and Prostrate.
Underexpressed in Ovarian, and Pancreatic.
Scientific Papers found: Click to Expand⟱
8245- LCA,    Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity
- in-vivo, LiverDam, NA
*hepatoP↑, *Apoptosis↓, *mtDam↓, *ROS↓, *NRF2↑, *Keap1↓, *ARE↑, *ALAT↓, *AST↓, *MDA↓, *MPO↓, *SOD↑, *GSH/GSSG↑, *Bcl-2↑, *BAX↓, *cl‑Casp3↓, *p‑cJun↓, *AIF↓, *Cyt‑c↓,
8243- LCA,    Licochalcone A Inhibits Cellular Motility by Suppressing E-cadherin and MAPK Signaling in Breast Cancer
- in-vitro, BC, MDA-MB-231
Inflam↓, AntiTum↑, TumAuto↑, Sp1/3/4↓, TumCMig↓, MAPK↓, Akt↓, cl‑Casp3↑, cl‑Casp9↑, Bcl-2↓, Cyt‑c↑, TumCP↓, ROS↑, Apoptosis↑, TumCMig↓, TumCI↓, MMP↓, γH2AX↑,
8254- LCA,  Geld,    Licochalcone A enhances geldanamycin-induced apoptosis through reactive oxygen species-mediated caspase activation
- in-vitro, Ovarian, NA
MMP↓, Cyt‑c↑, Casp↑, cl‑PARP1↑, ROS↑, GSH↓, eff↓,
8209- LCA,    Licochalcone A Exerts Anti-Cancer Activity by Inhibiting STAT3 in SKOV3 Human Ovarian Cancer Cells
- in-vitro, Ovarian, SKOV3
tumCV↓, TumCCA↑, ROS↑, MMP↓, Apoptosis↑, cl‑Casp↑, Cyt‑c↑, STAT3↓, TumCP↓, Dose↝, p‑STAT3↓,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8222- LCA,    Licochalcone A Induces Cholangiocarcinoma Cell Death Via Suppression of Nrf2 and NF-κB Signaling Pathways
- in-vitro, CCA, KKU-100 - in-vitro, CCA, KKU-213 - in-vitro, CCA, KKU-214 - in-vitro, CCA, KKU-156 - in-vitro, 0-Reserved, KKU-452
TumCP?, TumCD?, ROS↑, NRF2↓, BAX↑, Cyt‑c↑, TumCMig↓, TumCCA↑, NF-kB↓, STAT3↓, cycD1/CCND1↓, VEGF↓, ICAM-1↓,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8279- LE,    18β-Glycyrrhetinic Acid Has Anti-Cancer Effects via Inducing Apoptosis and G2/M Cell Cycle Arrest, and Inhibiting Migration of A549 Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H23 - in-vitro, Lung, H460
tumCV↓, selectivity↑, Apoptosis↑, ROS↑, TumCCA↑, TumCMig↓, TumCP↓, MMP↓, BAD↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, p‑STAT3↓, NF-kB↓,
8294- lign,    Secoisolariciresinol diglucoside induces pyroptosis by activating caspase-1 to cleave GSDMD in colorectal cancer cells
- vitro+vivo, CRC, LoVo - in-vitro, CRC, SW-620 - in-vitro, NA, SW480 - in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116
tumCV↓, Pyro↑, cl‑GSDMD↑, cl‑Casp1↑, ROS↑, p‑PI3K↓, TumCG↓, BAX↑, Cyt‑c↑, PI3K↓, Akt↓,
8403- LT,    Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells
- in-vitro, CRC, HT-29
tumCV↓, selectivity↑, Apoptosis↑, Casp↑, MMP↓, Ca+2↑, BAX↑, Bcl-2↓, Cyt‑c↑, Casp9↑, Casp3↑, ROS↓, SOD↑, Catalase↑, GSH↑, antiOx↑, MAPK↑,
8401- LT,    Multi-Faceted Role of Luteolin in Cancer Metastasis: EMT, Angiogenesis, ECM Degradation and Apoptosis
- Review, Var, NA
EMT↓, N-cadherin↓, Vim↓, VEGF↓, VEGFR1↓, MMPs↓, Telomerase↓, NF-kB↓, cMyc↓, Bax:Bcl2↑, Casp3↑, PI3K↓, Akt↓, FOXO3↑, P21↑, p27/CDKN1B↑, cl‑PARP↑, Cyt‑c↑, NOTCH↓, HES1↓, ROS↑, SOD↓, miR-34b-5p↑, Hif1a↓, P21↓, survivin↓, Mcl-1?, Bcl-xL↓, MDM2↓, MMP2↓, MMP9↓, MMP3↓, MMP16↓, miR-384↑, NRF2↓, HO-1↓, angioG↓,
8399- LT,    Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ-dependent mechanism in Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *cognitive↑, *neuroP↑, *Aβ↓, *mtDam↓, *Apoptosis↓, *PPARγ↑, *ROS↓, *SOD↑, *GSH↑, *NRF2↑, *MFN2↑, *DRP1/DNM1L↓, *FIS1↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *cl‑Casp9↓, *cl‑Casp3↓, *IDE↑, *BACE/β-secretase↓, *Aβ42↓,
2923- LT,    Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells
- in-vitro, neuroblastoma, NA
Apoptosis↑, TumCD↑, Casp12↑, Casp9↑, Casp3↑, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, GRP94↑, cl‑ATF6↑, p‑eIF2α↑, MMP↓, JNK↓, p38↑, ERK↑, Cyt‑c↑,
2903- LT,    Luteolin induces apoptosis by ROS/ER stress and mitochondrial dysfunction in gliomablastoma
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vivo, NA, NA
ER Stress↑, ROS↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, Casp12↑, eff↓, UPR↑, MMP↓, Cyt‑c↑, Bcl-2↓, BAX↑, TumCG↓, Weight∅, ALAT∅, AST∅,
2904- LT,    Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons
- in-vitro, Park, SK-N-SH - in-vitro, AD, NA
*ROS↓, *neuroP↑, *MMP↑, *Catalase↑, *GSH↑, selectivity↑, *eff↑, *Cyt‑c↓,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
3263- Lyco,    Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening
- in-vitro, Nor, H9c2 - in-vitro, Stroke, NA
*Apoptosis↓, *MMP↑, *Cyt‑c↓, *APAF1↓, *cl‑Casp9↓, *cl‑Casp3↓, *Bcl-2↑, *BAX↓, cardioP↑,
8420- Lyco,    Anticancer activity of lycopene in HT-29 colon cancer cell line
- in-vitro, CRC, HT-29
Risk↓, Dose↝, TumCP↓, Casp3↑, BAX↑, cl‑PARP↑, 8-oxo-dG↑, γH2AX↑, Cyt‑c↑,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
4794- Lyco,    Anticancer Effect of Lycopene in Gastric Carcinogenesis
- Review, GC, NA
*AntiCan↑, *ROS↓, *GSH↑, *GPx↑, *GSTs↑, TumCG↓, Apoptosis↑, ERK↓, Bcl-2↓, BAX↑, Cyt‑c↑, TumCCA↑, *DNAdam↓,
2545- M-Blu,    Reversing the Warburg Effect as a Treatment for Glioblastoma
- in-vitro, GBM, U87MG - NA, AD, NA - in-vitro, GBM, A172 - in-vitro, GBM, T98G
Warburg↓, OCR↑, lactateProd↓, TumCP↓, TumCCA↑, AMPK↑, ACC↓, Cyc↓, neuroP↑, Cyt‑c↝, Glycolysis↓, ECAR↓, TumCG↓, other↓,
8524- MAG,    Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, CRC, HCT116
Apoptosis↑, Akt?, BAD↑, Cyt‑c↑, cl‑Casp8↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, NA⇅, selectivity↑, p‑EGFR↓, p‑PI3K↓, p‑Akt↓,
8521- MAG,    Magnolol induces apoptosis via caspase-independent pathways in non-small cell lung cancer cells
- in-vitro, Lung, A549 - in-vitro, Lung, H520 - in-vitro, Lung, NCI-H441
TumCP↓, DNAdam↑, MMP↓, selectivity↑, BID↑, BAX↑, Cyt‑c↑, AIF↑, Endon↑, cl‑PARP↑, PI3K↓, Akt↓, ERK↓, p38↑, JNK↑,
8497- MAG,    Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway
- in-vitro, BC, MCF7
TumCP↓, Apoptosis↑, *TumCCA↑, *ROS↑, *MMP↓, *Cyt‑c↑, *AIF↑, *BAX↑, *P21↑, *P53↑, *Bcl-2↓, *CycB/CCNB1↓, *CDK1↓,
4534- MAG,    Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells
- in-vitro, Liver, HepG2 - in-vitro, CRC, COLO205
AntiCan↑, Apoptosis↑, selectivity↑, Ca+2↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,
4531- MAG,    Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway
- in-vitro, CRC, HCT116
Apoptosis↑, DNAdam↑, Casp3↑, cl‑PARP↑, p‑AMPK↑, Bcl-2↓, P53↑, BAX↑, Cyt‑c↑, TumCMig↓, TumCI↓,
4519- MAG,    Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiAg↑, *BBB↑, *BioAv↓, BAD↑, Casp3↑, Casp6↑, Casp9↑, JNK↑, Bcl-xL↓, PTEN↑, Akt↓, NF-kB↓, MMP7↓, MMP9↓, uPA↓, Hif1a↓, VEGF↓, FOXO3↓, Ca+2↑, TumCCA↑, ROS↑, Cyt‑c↑,
8536- Matr,    Effect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway
- vitro+vivo, BC, 4T1 - in-vitro, BC, MCF7
tumCV↓, Apoptosis↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, angioG↓,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8552- Matr,    Matrine exerts its neuroprotective effects by modulating multiple neuronal pathways
- Review, AD, NA
*BBB↑, *neuroP↑, *HMGB1↓, *NF-kB↓, *MyD88↓, *TLR4↓, *TRAF6↓, *Cyt‑c↓, *MDA↓, *Beclin-1/ATG6↑, *GPx↑, *IL23↓, *IL17↓, *NRF2↑, *HO-1↑, *SOD↑, *GSH↑, *Stroke↓, *BACE/β-secretase↓, *Aβ↓, *BDNF↑, *AChE↓, *BChE↓, *ROS↓, *memory↑, *NP/CIPN↓,
8626- MBZ,    The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells
- in-vitro, Lung, NA
mitA↑, Apoptosis↑, Casp↑, Cyt‑c↑, AntiTum↑, TumMeta↓, toxicity↓,
8632- MBZ,    Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo
- vitro+vivo, Lung, NA
Apoptosis↑, TumCCA?, Cyt‑c↑, selectivity↑,
8648- MBZ,    Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature
- Review, Var, NA
angioG↓, MMPs↓, MDR1↓, TubPol↓, RadioS?, ChemoSen?, TumCG↓, TumMeta?, OS↑, BioAv↓, BioAv↑, BBB↑, mitA↑, HH↓, Shh↓, Synergy↑, Gli1↓, PTCH2↓, XIAP↓, cl‑PARP↑, Casp3↑, BRAF↓, MEK↓, SYN1↑, Cyt‑c↑, TumVol↓, VEGFR2/KDR/Flk1↓, VEGF↓, VCAM-1↓, DYRK1B↓, QoL↑, Dose↝,
8725- MeJa,    Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice
- vitro+vivo, HCC, HCCLM3 - in-vitro, Liver, Bel-7402 - in-vitro, Liver, Hep3B - in-vitro, HCC, SMMC-7721 cell
HK2↓, MMP↓, Cyt‑c↑, AIF↑, Glycolysis↓, ChemoSen↑, selectivity↑, lactateProd↓, GlucoseCon↓, Synergy↑, Synergy↑,
8756- MeSA,    THE MAIN CYTOTOXIC EFFECTS OF METHYLSELENINIC ACID ON VARIOUS CANCER CELLS
- Review, Var, NA
ROS↑, GSH↓, RadioS↑, angioG↓, p‑Akt↓, IκB↓, NF-kB↓, ITGB3↓, p‑FOXO3↓, BAX↑, Cyt‑c↑, proCasp3↑, PARP↑, Glycolysis↓, TCA↓, NRF2↑, DNMT1↓, Hif1a↓, ER Stress↑, ChemoSen↑,
8759- MeSA,    Methylseleninic acid induces apoptosis of human bladder cancer cells through the ROS-mediated mitochondrial pathway
- in-vitro, Bladder, J82 - in-vitro, CRC, T24/HTB-9
tumCV↓, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, eff↓, BAX↑, Bcl-2↓, Cyt‑c↑, Casp9↑, Casp3↑,
2241- MF,    Pulsed electromagnetic therapy in cancer treatment: Progress and outlook
- Review, Var, NA
other↝, p‑ERK↝, P53↝, Cyt‑c↝, OXPHOS↑, Apoptosis↑, ROS↑,
2255- MF,    Pulsed Electromagnetic Fields Induce Skeletal Muscle Cell Repair by Sustaining the Expression of Proteins Involved in the Response to Cellular Damage and Oxidative Stress
- in-vitro, Nor, SkMC
*HSP70/HSPA5↑, *Apoptosis↓, *Inflam↓, *Trx↓, *PONs↓, *SOD2↓, *TumCG↑, *Diff↑, *HIF2a↑, *Cyt‑c↑, P21↑,
520- MF,    Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3β signaling pathway
- in-vitro, Nor, NA
*MPT↑, *Cyt‑c↑, *ROS↑, *p‑GSK‐3β↑, *eff↓, *MMP∅, *BAX↓, *Bcl-2∅,
2259- MFrot,  MF,    Method and apparatus for oncomagnetic treatment
- in-vitro, GBM, NA
MMP↓, Bcl-2↓, BAX↑, Bak↑, Cyt‑c↑, Casp3↑, Casp9↑, DNAdam↑, ROS↑, lactateProd↑, Apoptosis↑, MPT↑, *selectivity↑, ChemoSen↑, MMP↓, selectivity↑, TCA?, H2O2↑, eff↑, *antiOx↑, H2O2↑, eff↓, GSH/GSSG↓, *toxicity∅, OS↑,
3493- MFrot,  MF,    Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes
- in-vivo, GBM, NA
TumCD↑, MMP↓, Cyt‑c↑, Apoptosis↑, OS↑, DNAdam↑,
184- MFrot,  MF,    Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells
- in-vitro, GBM, GBM
ROS↑, mitResp↓, mtDam↑, Dose↝, MMP?, OCR↓, mt-H2O2↑, eff↓, SDH↓, Thiols↓, GSH↓, TumCD↑, Casp3↑, Casp7↑, MPT↑, Cyt‑c↑, selectivity↑, GSH/GSSG↓, ETC↓,
1891- MGO,    Methylglyoxal induces mitochondria-dependent apoptosis in sarcoma
- in-vitro, SCC, NA
NADH↓, MMP↓, Cyt‑c↑, selectivity↑, Apoptosis↑, ROS↑, ATP↓,
8737- MGO,    Induction of mitochondrial apoptotic pathway in triple negative breast carcinoma cells by methylglyoxal via generation of reactive oxygen species
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1
TumCP↓, TumCD↑, Apoptosis↑, ROS↑, eff↓, Cyt‑c↑, BAX↑, Bcl-2↓, p‑Akt↓, NF-kB↓,
8669- MLT,    Melatonin in lung cancer: integrating molecular mechanisms, tumor microenvironment regulation, apoptotic signaling, and therapeutic opportunities
- Review, Lung, NA
Apoptosis↑, ROS↑, Cyt‑c↑, Bcl-2↓, Casp↑, TumCP↓, TumCI↓, angioG↓, Inflam↓, ChemoSen↑, RadioS↑,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
1762- MNPs,  Fe,    Triggering the apoptosis of targeted human renal cancer cells by the vibration of anisotropic magnetic particles attached to the cell membrane
- in-vitro, RCC, NA
Dose∅, Apoptosis↑, Casp↑, tumCV↓, Casp3↑, Casp7↑, Ca+2↑, Cyt‑c↑,
8910- MO,    Moringa oleifera L. leaf extract induces cell cycle arrest and mitochondrial apoptosis in Dalton's Lymphoma: An in vitro and in vivo study
- vitro+vivo, lymphoma, NA
TumCP↓, MMP↓, TumCCA↑, P53↑, P21↑, BAX↑, Cyt‑c↑, Casp3↑, Bcl-2↑, Apoptosis↑, MEK↓, ERK↓,

Showing Research Papers: 301 to 350 of 464
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 464

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA⇅, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 5,   antiOx⇅, 1,   Catalase↓, 10,   Catalase↑, 3,   Ceru↓, 1,   Copper↑, 1,   Fenton↑, 5,   GCLM↓, 1,   GPx↓, 5,   GPx4↓, 6,   GSH↓, 41,   GSH↑, 6,   mt-GSH↓, 1,   GSH/GSSG↓, 6,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 3,   GSTs↑, 2,   GSTs↝, 1,   H2O2↑, 8,   i-H2O2↑, 1,   mt-H2O2↑, 1,   HO-1↓, 8,   HO-1↑, 12,   HO-1⇅, 1,   HO-2↓, 1,   Iron↑, 2,   c-Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 4,   lipid-P↑, 18,   MDA↓, 3,   MDA↑, 8,   MPO↓, 1,   NADH↓, 2,   NADPH/NADP+↓, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 16,   NRF2↑, 15,   NRF2⇅, 1,   NRF2↝, 1,   p‑NRF2↓, 1,   p‑NRF2↑, 1,   Prx↓, 1,   Prx4↑, 1,   PrxII↓, 1,   ROS?, 1,   ROS↓, 19,   ROS↑, 274,   ROS⇅, 5,   ROS↝, 1,   i-ROS↑, 4,   mt-ROS↑, 8,   SOD↓, 15,   SOD↑, 5,   SOD2↓, 5,   SOD2↑, 4,   TAC↓, 1,   TBARS↓, 1,   Thiols↓, 3,   Trx↓, 2,   Trx1↓, 1,   Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 5,   TrxR1↓, 2,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   FTH1↓, 2,   IronCh↑, 2,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 7,   CDC25↓, 14,   compI↓, 2,   compIII↓, 1,   compV↓, 1,   EGF↓, 4,   ETC↓, 5,   ETC↝, 1,   HTRA2/Omi/PARK13↑, 1,   MFN2↓, 1,   MFN2↑, 1,   mitResp↓, 6,   mitResp↑, 1,   MKK7↓, 1,   mtDam↑, 33,   OCR↓, 7,   OCR↑, 1,   OXPHOS↓, 2,   OXPHOS↑, 5,   mt-OXPHOS↓, 3,   PDH↓, 1,   PDH↑, 2,   PDH↝, 1,   PINK1↑, 2,   SDH↓, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 4,   5LO↓, 1,   ACC↓, 1,   ACC↑, 2,   ACSL4↑, 2,   ALAT↓, 1,   ALAT∅, 1,   AMP↑, 1,   AMPK?, 1,   AMPK↓, 2,   AMPK↑, 20,   AMPK↝, 1,   p‑AMPK↑, 2,   ATP↓, 24,   CAIX/CA9↓, 1,   ECAR↓, 1,   ECAR↝, 1,   FABP4↑, 1,   FASN↓, 4,   GALNT10↓, 1,   GAPDH↓, 2,   glucoNG↓, 1,   GlucoseCon↓, 9,   GlutaM↓, 1,   GlutMet↓, 1,   Glycolysis↓, 29,   GSK‐3β↓, 7,   GSK‐3β↑, 6,   p‑GSK‐3β↓, 6,   H2S↑, 1,   HK2?, 1,   HK2↓, 18,   lactateProd↓, 13,   lactateProd↑, 2,   LDHA↓, 7,   LDL↓, 2,   NADPH↓, 1,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 8,   PDKs↓, 1,   PFK↓, 2,   PFKP↓, 1,   PKM2↓, 7,   PKM2↑, 1,   PKM2∅, 1,   Pyruv↓, 1,   p‑S6↓, 1,   SIRT1↓, 9,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,   TCA?, 1,   TCA↓, 2,   TS↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 35,   AIF↝, 1,   APAF1↑, 14,   Apoptosis?, 1,   Apoptosis↓, 8,   Apoptosis↑, 260,   Apoptosis↝, 1,   mt-Apoptosis↑, 3,   ASC↓, 1,   ASK1↑, 2,   BAD↓, 2,   BAD↑, 24,   Bak↓, 1,   Bak↑, 16,   BAX↓, 4,   BAX↑, 192,   BAX⇅, 1,   BAX↝, 2,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 44,   Bcl-2↓, 173,   Bcl-2↑, 1,   Bcl-2↝, 2,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 36,   Bcl-xL↑, 2,   Bcl-xL↝, 1,   BID↑, 14,   cl‑BID↑, 4,   BIM↓, 1,   BIM↑, 7,   BNIP3?, 1,   BNIP3↓, 1,   BNIP3↑, 2,   BNIP3↝, 1,   BOK↑, 1,   Casp↑, 58,   cl‑Casp↑, 3,   Casp1↓, 1,   Casp1↑, 1,   cl‑Casp1↑, 1,   Casp10↑, 2,   Casp12↑, 12,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3?, 2,   Casp3↓, 6,   Casp3↑, 210,   Casp3↝, 2,   Casp3∅, 2,   cl‑Casp3↑, 54,   cl‑Casp3⇅, 1,   proCasp3↓, 2,   proCasp3↑, 3,   pro‑Casp3↑, 1,   Casp6↑, 4,   Casp7↑, 15,   cl‑Casp7↑, 6,   Casp8↓, 2,   Casp8↑, 55,   Casp8∅, 3,   cl‑Casp8↑, 9,   proCasp8↓, 1,   proCasp8↑, 1,   Casp9?, 1,   Casp9↓, 1,   Casp9↑, 153,   Casp9∅, 1,   cl‑Casp9↓, 1,   cl‑Casp9↑, 29,   proCasp9↓, 3,   proCasp9↑, 2,   cFLIP↓, 6,   Cupro↑, 2,   Cyt‑c↓, 5,   Cyt‑c↑, 421,   Cyt‑c↝, 8,   Cyt‑c?, 1,   mt-Cyt‑c↓, 1,   Diablo↑, 22,   DR5↑, 32,   Endon↑, 4,   FADD↑, 12,   Fap1↓, 1,   Fas↓, 1,   Fas↑, 39,   FasL↑, 21,   FasL⇅, 1,   Ferroptosis↑, 7,   cl‑GSDMD↑, 1,   cl‑GSDME↑, 1,   GSDME-N↑, 1,   HEY1↓, 1,   IAP1↓, 11,   IAP1↑, 1,   IAP2/BIRC3↓, 4,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 2,   ICAD↑, 1,   ICD↑, 1,   iNOS↓, 14,   Mcl-1?, 1,   Mcl-1↓, 26,   cl‑Mcl-1↑, 1,   MDM2↓, 11,   MDM2↑, 2,   p‑MDM2↓, 2,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↓, 2,   MOMP↑, 8,   NAIP↓, 1,   Necroptosis↑, 2,   necrosis↑, 2,   NOXA↑, 3,   p38↓, 5,   p38↑, 27,   p‑p38↓, 2,   p‑p38↑, 7,   Paraptosis↑, 1,   PUMA↑, 6,   Pyro↑, 5,   RIP1↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   survivin↓, 49,   TNFR 1↑, 1,   TRAIL↑, 5,   TRAILR↑, 1,   TumCD?, 1,   TumCD↑, 27,   XIAP↓, 31,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 104,   Akt↑, 5,   Akt↝, 1,   p‑Akt↓, 34,   p‑Akt↑, 1,   AKT1↓, 3,   Akt2↓, 1,   AMPKα↑, 1,   BRAF↓, 1,   CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 4,   cMET↓, 1,   p‑cMET↑, 1,   p‑CREB↓, 1,   CREB2↓, 1,   cSrc↓, 1,   DYRK1B↓, 1,   EGFR↓, 33,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 3,   ERK↓, 41,   ERK↑, 10,   p‑ERK↓, 14,   p‑ERK↑, 3,   p‑ERK↝, 1,   FGFR1↓, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 13,   HGF/c-Met↓, 3,   Hippo↓, 1,   IGF-1R↓, 2,   IGF-1R↑, 1,   IGFR↓, 2,   IKKα↓, 3,   IKKα↑, 2,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 2,   JAK1↓, 3,   JAK1↑, 1,   JAK2↓, 4,   p‑JAK2↓, 2,   JNK↓, 7,   JNK↑, 29,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 7,   MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 30,   MAPK↑, 14,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 2,   MEK↓, 8,   p‑MEK↑, 1,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 48,   mTOR↑, 1,   mTOR↝, 3,   p‑mTOR↓, 11,   mTORC2↓, 4,   p70S6↓, 2,   p70S6↑, 1,   P70S6K↓, 4,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 71,   PI3K↑, 2,   PI3K↝, 1,   p‑PI3K↓, 8,   PI3K/Akt↓, 3,   PI3k/Akt/mTOR↝, 1,   PIK3CA↓, 1,   PKA↓, 2,   PKCδ↓, 10,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 15,   PTEN↝, 1,   Raf↓, 5,   RAS↓, 9,   RSK2/RPS6KA3/p90RSK2↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 11,   Src↓, 2,   p‑Src↓, 1,   STAT3↓, 34,   STAT3↑, 1,   p‑STAT3↓, 13,   STAT5↓, 1,   STAT6↓, 1,   p‑STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF1↓, 1,   ATF3↓, 1,   ATF3↑, 3,   ATF4↓, 1,   ATF4↑, 13,   ATF4↝, 1,   ChrMod↑, 1,   ChrMod↝, 1,   cJun↓, 7,   cJun↑, 3,   p‑cJun↑, 1,   cMyc↓, 21,   DNMT1↓, 4,   DNMT3A↓, 2,   DNMTs↓, 6,   FOXM1↓, 2,   FOXO↑, 2,   FOXO1↓, 2,   FOXO3↓, 4,   FOXO3↑, 6,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 4,   H3↑, 1,   p‑H3↓, 1,   p‑H3↑, 1,   ac‑H3↑, 1,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 5,   HATs↑, 2,   HDAC↓, 22,   HDAC1↓, 2,   HDAC10↑, 1,   HDAC3↓, 1,   HDAC8↓, 1,   HES1↓, 1,   KCNQ1OT1↓, 1,   miR-122-5p↑, 1,   miR-203↑, 1,   miR-21↓, 3,   miR-21↑, 1,   miR-22↑, 2,   miR-34a↓, 1,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-497↑, 1,   miR-548ah-5p↑, 1,   Myc↓, 3,   OCT4↓, 6,   other?, 1,   other↓, 3,   other↑, 3,   other↝, 8,   PAX2↓, 1,   sonoS↑, 1,   SOX2↓, 3,   SOX4↓, 1,   SOX4↑, 1,   SOX9↓, 1,   TCF-4↓, 2,   TFAP2A↓, 1,   TFE3↑, 1,   tumCV?, 1,   tumCV↓, 66,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   cl‑ATF6↑, 2,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 36,   eIF2α↓, 1,   eIF2α↑, 7,   p‑eIF2α↓, 1,   p‑eIF2α↑, 4,   ER Stress↓, 1,   ER Stress↑, 62,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 20,   GRP94↑, 2,   HSF1↓, 1,   HSP27↓, 6,   HSP27↑, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 9,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP72↓, 1,   HSP90↓, 11,   HSPs↓, 2,   IRE1↑, 8,   PERK↑, 13,   UPR↑, 12,   XBP-1↓, 1,   XBP-1↑, 4,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 2,   ATG5↑, 9,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 15,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 4,   LC3A↑, 2,   LC3B↑, 3,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↑, 13,   LC3s↓, 1,   LC3s↑, 3,   MitoP↑, 2,   p62↓, 5,   p62↑, 5,   PARK2↑, 2,   RUBCN↓, 1,   SESN2↑, 2,   TumAuto↓, 1,   TumAuto↑, 37,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   ATM↑, 2,   BRCA1↓, 1,   BRCA2↓, 1,   DFF45↓, 1,   DFF45↑, 1,   DNA-PK↑, 1,   DNAdam↓, 1,   DNAdam↑, 65,   mt-DNAdam↑, 1,   DNArepair↓, 2,   ERCC1↓, 1,   ERCC4/XPF↓, 1,   hTERT/TERT↓, 12,   Ku70/XRCC6↓, 1,   p16↑, 4,   P53?, 1,   P53↓, 3,   P53↑, 89,   P53↝, 4,   p‑P53↑, 5,   PARP↓, 7,   PARP↑, 21,   PARP↝, 1,   p‑PARP↑, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 99,   cl‑PARP∅, 1,   PARP1↑, 1,   cl‑PARP1↑, 4,   PCNA↓, 24,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 17,   TOP1↓, 9,   TOP1∅, 1,   TOP2↓, 6,   TP53↓, 1,   TRF2↓, 1,   γH2AX↑, 7,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 15,   CDK1↑, 1,   p‑CDK1↓, 2,   CDK2↓, 33,   CDK2↑, 3,   p‑CDK2↓, 1,   CDK4↓, 43,   CDK4↑, 2,   CDK6↓, 18,   CDK6↑, 2,   CDK8↓, 1,   CHK1↓, 2,   CHK1↑, 2,   Chk2↓, 2,   Chk2↑, 2,   ChrCon↑, 1,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 9,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 19,   CycB/CCNB1↑, 4,   cycD1/CCND1↓, 67,   cycD1/CCND1↑, 2,   cycD1/CCND1↝, 2,   CycD3↓, 3,   cycE/CCNE↓, 23,   cycE/CCNE↑, 1,   cycF↓, 1,   E2Fs↓, 1,   GADD45A↓, 1,   Ki-67↓, 16,   MAD↓, 1,   mitA↓, 1,   mitA↑, 3,   p19↑, 1,   P21↓, 3,   P21↑, 67,   P21↝, 2,   p27/CDKN1B↑, 26,   pRB↑, 1,   p‑pRB↓, 3,   RB1↑, 2,   p‑RB1↓, 5,   Securin↓, 1,   TubPol↓, 1,   TumCCA?, 2,   TumCCA↓, 9,   TumCCA↑, 165,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 1,   ALDH↓, 3,   ALDH1A1↓, 1,   CD133↓, 3,   CD24↓, 1,   CD34↓, 2,   CEBPA↑, 1,   cFos↓, 7,   cFos↑, 1,   CSCs↓, 22,   Diff↑, 2,   EIF4E↓, 1,   FGF↓, 2,   Gli↓, 1,   Gli1↓, 6,   HH↓, 3,   IGF-1↓, 7,   IGF-2↓, 1,   IGFBP3↓, 1,   IGFBP3↑, 5,   Jun↓, 1,   Ki-67↓, 16,   Let-7↑, 1,   mTORC1↓, 7,   Nanog↓, 4,   NOTCH↓, 12,   NOTCH1↓, 5,   NOTCH1↑, 2,   NOTCH3↓, 1,   PTCH1↓, 1,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 3,   STAT1↓, 1,   TumCG↓, 73,   TumCG↑, 2,   TumCP?, 1,   TumCP↓, 102,   TumCP↑, 3,   Wnt?, 1,   Wnt↓, 27,   Wnt↑, 1,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 5,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 3,   BACH1↓, 1,   CA↓, 1,   Ca+2↓, 3,   Ca+2↑, 59,   Ca+2↝, 2,   i-Ca+2?, 1,   i-Ca+2↑, 3,   CAFs/TAFs↓, 2,   cal2↓, 1,   cal2↑, 5,   CCN2/CTGF↓, 1,   Cdc42↓, 2,   E-cadherin↓, 6,   E-cadherin↑, 34,   EMT↓, 47,   EMT↑, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 16,   p‑FAK↓, 3,   Fibronectin↓, 3,   GLI2↓, 2,   ITGB1↓, 2,   ITGB3↓, 1,   ITGB4↓, 1,   ITGB6↓, 1,   KRAS↓, 1,   LAMs↓, 2,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 4,   p‑MET↓, 1,   MMP-10↓, 3,   MMP1↓, 5,   MMP13↓, 2,   MMP16↓, 1,   MMP2↓, 62,   MMP2↝, 1,   proMMP2↓, 1,   MMP3↓, 6,   MMP7↓, 10,   MMP9↓, 66,   MMP9↑, 1,   MMPs↓, 24,   MRGPRF↓, 1,   MTA1↓, 1,   MUC4↓, 1,   N-cadherin↓, 25,   p44↓, 1,   PAK1↑, 1,   pax↓, 1,   PDGF↓, 5,   Rac1↓, 2,   RECK↑, 1,   Rho↓, 5,   ROCK1↓, 2,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 8,   Smad1↑, 3,   SMAD2↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 2,   p‑SMAD3↓, 1,   SMAD4↓, 1,   p‑SMAD4↓, 1,   Snail?, 2,   Snail↓, 23,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 12,   TGF-β↑, 3,   TIMP1↓, 1,   TIMP1↑, 5,   TIMP2↓, 4,   TIMP2↑, 9,   TIMP3↑, 1,   TRIB3↑, 2,   TSC1↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCA↑, 1,   TumCI↓, 50,   TumCI↑, 1,   TumCMig↓, 37,   TumCMig↑, 1,   TumMeta?, 1,   TumMeta↓, 47,   TumMeta↑, 3,   Twist↓, 16,   Tyro3↓, 1,   uPA↓, 25,   uPA↝, 1,   uPAR↓, 2,   Vim↓, 24,   Vim↑, 1,   Zeb1↓, 9,   Zeb1↑, 1,   ZEB2↓, 2,   α-SMA↓, 1,   α-SMA↑, 1,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 33,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 68,   angioG↑, 1,   CD31/PECAM-1↓, 3,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 4,   Hif1a↓, 43,   Hif1a↑, 2,   LOX1↓, 2,   NO↓, 3,   NO↑, 4,   NO↝, 1,   VCAM-1↓, 2,   VEGF↓, 74,   VEGF↝, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 14,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 6,   BBB∅, 1,   CellMemb↓, 1,   CLDN1↓, 2,   CLDN2↓, 2,   CLDN2↑, 1,   EPR↑, 4,   EPR↝, 1,   GLUT1↓, 8,   GLUT2↓, 1,   GLUT3↓, 1,   GLUT4↓, 1,   MMP?, 1,   MMP↓, 235,   MMP↑, 2,   MPT↑, 16,   NHE1↓, 3,   TRPM7↓, 2,   TRPV1↑, 5,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 3,   CD44↓, 12,   CD8+↑, 2,   cDC2↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 59,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL12↓, 1,   CXCR2↓, 1,   CXCR4↓, 9,   CXCR4↑, 1,   DR4↑, 10,   DR4∅, 1,   FOXP3↑, 2,   HCAR2↑, 1,   HMGB1↓, 2,   ICAM-1↓, 5,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 4,   IL1↑, 1,   IL10↓, 4,   IL12↓, 1,   IL12↑, 1,   IL1β↓, 13,   IL1β↑, 2,   IL2↓, 1,   IL2↑, 3,   IL4↓, 2,   IL6↓, 22,   IL6↝, 1,   IL8↓, 6,   IL8↑, 1,   Imm↑, 7,   Imm↝, 4,   Inflam↓, 22,   M2 MC↓, 2,   MCP1/CCL2↓, 5,   MCT1↓, 2,   MDSCs↓, 1,   NF-kB?, 1,   NF-kB↓, 106,   NF-kB↑, 10,   NF-kB↝, 1,   NK cell↑, 1,   NLRP3↓, 2,   p50↓, 2,   p65↓, 3,   p‑p65↓, 1,   p‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 7,   PGE2↓, 14,   PSA↓, 4,   PSA↝, 1,   RAGE↓, 1,   RANTES?, 1,   SOCS-3↓, 1,   T-Cell↑, 1,   TCF↑, 1,   TCF↝, 1,   TLR4↓, 6,   TNF-α↓, 23,   TNF-α↑, 4,   TNF-α↝, 1,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

SYN1↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 12,   AR↝, 1,   AR-V7?, 1,   CYP19?, 1,   ER-α36↓, 2,   ER(estro)↓, 1,   Estro↝, 1,   PPARα↓, 1,   PPARα↑, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 4,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 23,   BioAv↑, 22,   BioAv↝, 7,   BioEnh↑, 5,   ChemoSen?, 1,   ChemoSen↑, 100,   CompStab↑, 3,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 4,   DDS↑, 1,   Dose↓, 2,   Dose↑, 4,   Dose↝, 42,   Dose∅, 6,   eff↓, 58,   eff↑, 91,   eff↝, 13,   GSTA1↓, 1,   GSTA1↑, 1,   GSTZ1↝, 1,   Half-Life↓, 6,   Half-Life↝, 6,   MDR1↓, 4,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 11,   P450↓, 3,   P450↝, 1,   RadioS?, 1,   RadioS↑, 37,   RadioS↝, 1,   selectivity↓, 1,   selectivity↑, 95,   selectivity∅, 1,   Synergy↑, 67,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 1,   ALAT∅, 1,   ALP↓, 2,   AR↓, 12,   AR↝, 1,   AST↓, 1,   AST∅, 1,   BMD↑, 1,   BRAF↓, 1,   BRCA1↓, 1,   CEA↓, 2,   creat↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 33,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 3,   Ferritin↓, 2,   FOXM1↓, 2,   HER2/EBBR2↓, 13,   hTERT/TERT↓, 12,   IL6↓, 22,   IL6↝, 1,   KRAS↓, 1,   LDH?, 1,   LDH↓, 7,   LDH↑, 6,   LDH↝, 2,   i-LDH↓, 1,   Myc↓, 3,   NSE↓, 1,   PD-L1↓, 7,   PSA↓, 4,   PSA↝, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TP53↓, 1,   TRIB3↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 40,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 18,   cachexia↓, 2,   cardioP↑, 9,   CardioT↑, 1,   chemoP↑, 18,   chemoPv↑, 18,   ChemoSideEff↓, 2,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 7,   hepatoP∅, 1,   Mucositis↓, 1,   neuroP↑, 5,   NP/CIPN↓, 1,   NP/CIPN↑, 1,   Obesity↓, 1,   OS↑, 9,   Pain↓, 1,   Pin1↓, 1,   QoL↑, 3,   radioP↑, 4,   Remission↑, 1,   RenoP↑, 8,   Risk↓, 16,   Sleep↑, 1,   toxicity↓, 10,   toxicity↑, 4,   toxicity↝, 6,   toxicity∅, 3,   TumVol↓, 13,   TumW↓, 8,   Weight↑, 3,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 2,   GutMicro↑, 5,   GutMicro↝, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 1,  
Total Targets: 1019

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 2,   antiOx↑, 68,   ARE↑, 1,   Catalase↑, 24,   GPx↑, 18,   GPx1↑, 1,   GPx4↑, 2,   GSH↑, 28,   GSH/GSSG↑, 1,   GSR↓, 1,   GSR↑, 4,   GSTs↓, 1,   GSTs↑, 8,   H2O2↓, 3,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 15,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 20,   mt-lipid-P↓, 1,   MDA↓, 17,   MDA↑, 1,   MPO↓, 5,   NADH↓, 1,   NOX4↓, 1,   NQO1↑, 3,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 33,   Prx↑, 1,   RNS↓, 3,   ROS↓, 64,   ROS↑, 6,   ROS↝, 1,   ROS∅, 2,   mt-ROS?, 1,   SOD↓, 1,   SOD↑, 34,   SOD1↑, 2,   SOD2↓, 1,   SOD2↑, 3,   TAC↑, 3,   TBARS↓, 2,   Trx↓, 1,   Trx↑, 2,   uricA↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   FIS1↓, 1,   Insulin↑, 1,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 3,   PGC-1α↑, 4,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ALAT↓, 15,   AMPK↓, 1,   AMPK↑, 4,   ATP↓, 1,   ATP↑, 4,   ATP∅, 1,   cytoP450↓, 1,   DGAT1↓, 1,   FASN↓, 1,   GAPDH↑, 1,   glucose↓, 3,   glucose↝, 1,   GSK‐3β↓, 4,   p‑GSK‐3β↑, 1,   H2S↑, 1,   LDHA↑, 1,   LDL↓, 3,   lipidLev↓, 3,   NAD↓, 1,   NADH:NAD↑, 1,   NADPH↑, 1,   PONs↓, 1,   SIRT1↑, 7,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   AIF↑, 1,   APAF1↓, 1,   Apoptosis↓, 12,   Apoptosis∅, 1,   ASK1↓, 1,   BAX↓, 14,   BAX↑, 2,   Bax:Bcl2↝, 1,   Bcl-2↓, 2,   Bcl-2↑, 9,   Bcl-2∅, 1,   Bcl-xL↓, 1,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 16,   Casp3∅, 2,   cl‑Casp3↓, 3,   Casp8↓, 1,   Casp9↓, 7,   Casp9∅, 1,   cl‑Casp9↓, 2,   Cyt‑c↓, 24,   Cyt‑c↑, 5,   Cyt‑c∅, 4,   Ferroptosis↓, 2,   IAP1↓, 1,   iNOS↓, 11,   iNOS↑, 1,   MLKL↓, 1,   necrosis↓, 1,   p38↓, 1,   RIP1↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 1,   Akt2↓, 1,   CaMKII ↓, 1,   CREB↑, 1,   ERK↓, 1,   ERK↑, 3,   IGF-1R↓, 1,   IKKα↓, 1,   IκB?, 1,   JAK↓, 2,   JNK↓, 1,   p‑JNK↓, 2,   MAPK↓, 4,   mTOR↑, 1,   PDGFR-BB↓, 1,   PI3K↓, 5,   PI3K↑, 1,   PKCδ↓, 1,   STAT3↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   p‑cJun↓, 1,   p‑cMyc↑, 1,   FOXO↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   other↓, 2,   other↑, 5,   other↝, 7,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 2,   ER Stress↓, 2,   GRP78/BiP↓, 1,   HSP27↓, 1,   HSP27↑, 1,   HSP70/HSPA5↑, 3,   HSP70/HSPA5↝, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↓, 1,   PERK↓, 1,   UPR↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 2,   LC3II↓, 1,   LC3II↑, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   p16↓, 1,   P53↓, 4,   P53↑, 1,   PARP↓, 2,   PARP∅, 1,   PARP1↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 2,   P21↑, 1,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↑, 1,   IGF-1↑, 1,   Ki-67↓, 1,   TumCG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 6,   AP-1↓, 1,   Ca+2?, 1,   Ca+2↓, 1,   Ca+2↑, 1,   Ca+2↝, 2,   cal2↓, 1,   COL1↓, 1,   COL1↑, 1,   E-cadherin↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 2,   PAI-1/SERPINE1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 1,   TIMP1↓, 1,   TregCell↑, 1,   Zeb1↓, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   HIF2a↑, 1,   NO↓, 8,   NO↑, 1,   VCAM-1↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 10,   GastroP↑, 2,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   MMP↓, 2,   MMP↑, 13,   MMP∅, 2,   MPT↑, 1,   MUC5AC↓, 1,   OCLN↝, 1,   TJ↑, 1,   TRPA1↑, 1,   TRPV1↑, 1,   ZO-1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD4+↑, 1,   CD8+↑, 1,   COX1↓, 3,   COX2/PTGS2↓, 16,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 3,   IL1↓, 2,   IL10↓, 4,   IL10↑, 3,   IL17↓, 5,   IL18↓, 2,   IL1β↓, 12,   IL2↓, 1,   IL23↓, 1,   IL4↓, 1,   IL6↓, 16,   IL6↑, 1,   IL8↓, 2,   Imm↓, 1,   Imm↑, 3,   Inflam↓, 66,   Inflam↑, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 1,   MyD88↓, 2,   NF-kB↓, 21,   NF-kB↑, 1,   p65↓, 1,   PAF↓, 1,   PGE2↓, 8,   PGE2↑, 1,   RAGE↓, 1,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR1↓, 1,   TLR4↓, 3,   TNF-α↓, 28,   TRAF6↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   AChE↓, 7,   BChE↓, 3,   BDNF↓, 1,   BDNF↑, 4,   GABA↑, 1,   MAOA↓, 1,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 11,   Aβ42↓, 1,   BACE/β-secretase↓, 5,   IDE↑, 1,   tau↓, 2,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   Estro↓, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 5,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 21,   BioAv↑, 23,   BioAv↝, 4,   BioAv∅, 1,   BioEnh↑, 2,   CompStab↑, 1,   CYP2E1↓, 2,   Dose⇅, 1,   Dose↝, 7,   Dose∅, 1,   eff↓, 2,   eff↑, 16,   eff↝, 1,   Half-Life↓, 5,   Half-Life↑, 1,   Half-Life↝, 8,   Half-Life∅, 1,   P-gp/ABCB1↓, 2,   P450↓, 1,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 15,   ALB↝, 1,   ALP↓, 3,   AST↓, 14,   BP↓, 4,   BUN↓, 3,   creat↓, 4,   CRP↓, 3,   hs-CRP↓, 1,   IL6↓, 16,   IL6↑, 1,   LDH↓, 7,   LDH↑, 1,   NOS2↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 2,   antiAll↑, 12,   AntiArt↑, 7,   AntiCan↑, 8,   antiD↓, 1,   AntiDiabetic↑, 12,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 1,   Bone Healing↑, 1,   cardioP↑, 24,   chemoP↑, 5,   chemoPv↑, 4,   cognitive↑, 11,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 20,   Learn↑, 1,   memory↑, 9,   motorD↑, 4,   Mucositis↓, 1,   neuroP?, 1,   neuroP↑, 44,   NP/CIPN↓, 1,   Obesity↓, 5,   OS↑, 1,   Pain↓, 3,   radioP↑, 2,   RenoP↑, 7,   Risk↓, 1,   Stroke↓, 5,   toxicity↓, 21,   toxicity↑, 3,   toxicity↝, 4,   toxicity∅, 4,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 7,   AntiFungal↑, 3,   AntiP↑, 3,   AntiViral↑, 7,   Bacteria↓, 12,   Diar↓, 1,   GutMicro↑, 10,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 4,  
Total Targets: 393

Scientific Paper Hit Count for: Cyt‑c, cyt-c Release into Cytosol
16 Silver-NanoParticles
16 Betulinic acid
15 Curcumin
15 Fisetin
14 Baicalein
14 Sulforaphane (mainly Broccoli)
12 Apigenin (mainly Parsley)
12 Quercetin
11 Thymoquinone
10 Berberine
10 Emodin
9 Allicin (mainly Garlic)
9 Capsaicin
9 Luteolin
9 Phenethyl isothiocyanate
8 Carvacrol
8 Chrysin
7 Honokiol
7 Magnolol
7 Kaempferol
7 Licochalcone A
6 EGCG (Epigallocatechin Gallate)
6 Eugenol
6 Gambogic Acid
6 Juglone
6 Magnetic Fields
6 Silymarin (Milk Thistle) silibinin
5 Artemisinin
5 Graviola
5 Hibiscus sabdariffa
5 isoorientin
5 Resveratrol
5 Vitamin K2
4 3-bromopyruvate
4 Propolis -bee glue
4 Cisplatin
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 Thymol-Thymus vulgaris
4 Lycopene
4 Morin
4 Nimbolide
4 Shikonin
4 Selenite (Sodium)
3 Ashwagandha(Withaferin A)
3 Photodynamic Therapy
3 Crocetin
3 Dichloroacetate
3 D-limonene
3 Dandelion Root
3 Ellagic acid
3 Formononetin
3 Garcinol
3 Ginkgetin
3 Indole-3-carbinol
3 Ivermectin
3 Matrine
3 mebendazole
3 Magnetic Field Rotating
3 Rosmarinic acid
3 Spermidine
2 Chemotherapy
2 Celastrol
2 Citric Acid
2 Copper and Cu NanoParticles
2 Ursolic acid
2 Cynaropicrin
2 salinomycin
2 Diclofenac
2 Electrical Pulses
2 Eurycomanone
2 Radiotherapy/Radiation
2 Evodiamine
2 Flaxseed/Linseed
2 Gossypol/AT-101
2 Hyperthermia
2 HydroxyTyrosol
2 Hyperoside
2 Isoliquiritigenin
2 Licorice
2 methylseleninic acid
2 Methylglyoxal
2 Melatonin
2 Moringa oleifera
2 Methylsulfonylmethane
2 Phenylbutyrate
2 Piperine
2 Piperlongumine
2 Plumbagin
2 Aflavin-3,3′-digallate
1 1,8-Cineole
1 5-fluorouracil
1 Coenzyme Q10
1 Astragalus
1 chemodynamic therapy
1 SonoDynamic Therapy UltraSound
1 Camptothecin
1 Gemcitabine (Gemzar)
1 Ajoene (compound of Garlic)
1 Alpha-Lipoic-Acid
1 alpha Linolenic acid
1 Andrographis
1 Metformin
1 2-DeoxyGlucose
1 Biochanin A
1 Bufalin/Huachansu
1 Bromelain
1 Boron
1 Bullatacin
1 Butyrate
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cat’s Claw
1 chaetocin
1 Chlorophyllin
1 Cichoric acid / Chicoric acid
1 methotrexate
1 Cinnamon
1 Cucurbitacin
1 Dihydrocaffeic Acid
1 Diindolylmethane
1 Fenbendazole
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Gallic acid
1 Ginkgo biloba
1 Ginkgolide B
1 Hydroxycinnamic-acid
1 Baicalin
1 Isobavachalcone
1 iodine
1 phytic acid, Inositol hexakisphosphate
1 Isovitexin
1 Lapachol
1 Lasiodin
1 Geldanamycin
1 SDG/lignans
1 Methylene blue
1 Methyl Jasmonate
1 magnetic nanoparticles
1 Iron
1 Mangiferin
1 Mistletoe/Viscum album Extracts
1 Pterostilbene
1 Paclitaxel/Taxol
1 Rauwolfia serpentina/Indian Snakeroot
1 α-Santalol/Sandalwood oil
1 Selenium
1 chitosan
1 Selenium NanoParticles
1 Docetaxel
1 Osimertinib
1 Adagrasib
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 Urolithin
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 VitK3,menadione
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:77  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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