DNAdam Cancer Research Results

DNAdam, DNA damage: Click to Expand ⟱
Source: HalifaxProj(prevent)
Type:
DNA damage plays a crucial role in the development of cancer. The integrity of DNA is essential for the proper functioning of cells, and when DNA is damaged, it can lead to mutations that may contribute to cancer progression.
Scientific Papers found: Click to Expand⟱
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
8521- MAG,    Magnolol induces apoptosis via caspase-independent pathways in non-small cell lung cancer cells
- in-vitro, Lung, A549 - in-vitro, Lung, H520 - in-vitro, Lung, NCI-H441
TumCP↓, DNAdam↑, MMP↓, selectivity↑, BID↑, BAX↑, Cyt‑c↑, AIF↑, Endon↑, cl‑PARP↑, PI3K↓, Akt↓, ERK↓, p38↑, JNK↑,
4533- MAG,    Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways
- in-vitro, GC, SGC-7901
AntiCan↑, DNAdam↑, Apoptosis↑, TumCCA↑, Bax:Bcl2↑, MMP↓, Casp3↑, PI3K↓, Akt↓,
4531- MAG,    Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway
- in-vitro, CRC, HCT116
Apoptosis↑, DNAdam↑, Casp3↑, cl‑PARP↑, p‑AMPK↑, Bcl-2↓, P53↑, BAX↑, Cyt‑c↑, TumCMig↓, TumCI↓,
8627- MBZ,    Treatment of breast and colon cancer cell lines with anti-helmintic benzimidazoles mebendazole or albendazole results in selective apoptotic cell death
- in-vitro, CRC, HT-29 - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCD↑, selectivity↑, Apoptosis↑, Casp3↑, DNAdam↑, MOMP↑, ROS↑, TumCCA↑, eff↓, RadioS↑,
8634- MBZ,  Rad,    Mebendazole Potentiates Radiation Therapy in Triple-Negative Breast Cancer
- vitro+vivo, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
RadioS↑, TumCCA↑, DNAdam↑, Apoptosis↑, TumCD↑, *toxicity↓,
8650- MBZ,    Autophagy Is a Potential Target for Enhancing the Anti-Angiogenic Effect of Mebendazole in Endothelial Cells
- in-vitro, Var, NA
TumCP↓, TumCCA↑, Apoptosis↑, DNAdam↑, P53↑, Casp3↑, TumAuto↑, Synergy↑, eff↑,
8786- mCHEMO,    Metronomic chemotherapy in cancer treatment: new wine in an old bottle
- Review, Var, NA
eff↑, ChemoSideEff↓, angioG↓, *toxicity↓, PFS↑, Hif1a↓, TumCD↑, CSCs↓, EMT↓, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, CD133↓, TumCCA↑, P21↓, DNAdam↑, Imm↑, Synergy↑, Synergy↑,
8742- MeSA,    Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells
- in-vitro, Pca, DU145
TumCCA↑, DNAdam↑, Casp↑, cl‑PARP↑, p27/CDKN1B↑, P21↑, Apoptosis↑, Akt↓, ERK↓,
8764- MeSA,    Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition
- in-vitro, Lung, A549
FOXO3↑, DNAdam↑, ROS↓, TumCCA↑, Apoptosis↑, ChemoSen↑, Glycolysis↓, TCA↓, Synergy↑,
6536- MeSal,    Salicylates inhibit NF-kappaB activation and enhance TNF-alpha-induced apoptosis in human pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
p‑IKKα↓, Apoptosis↑, DNAdam↑, NF-kB↓,
5800- MET,    Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect
- Review, Var, NA
ChemoSen↑, RadioS↑, Imm↑, *AntiDiabetic↑, *AMPK↑, TumCP↓, hepatoP↑, ATP↓, AMP↑, glucoNG↓, ROS↑, compI↓, DNAdam↑, CSCs↓, NP/CIPN↓, chemoP↑, toxicity↓, Trx↓, Synergy↑, cycD1/CCND1↓, CDK4↓, CDK6↓, cycE/CCNE↓, CDK2↓,
489- MF,    Time-varying magnetic fields of 60 Hz at 7 mT induce DNA double-strand breaks and activate DNA damage checkpoints without apoptosis
- in-vitro, Cerv, HeLa - in-vitro, NA, IMR90
DNAdam↑,
488- MF,    Repetitive exposure to a 60-Hz time-varying magnetic field induces DNA double-strand breaks and apoptosis in human cells
- in-vitro, Var, HeLa - in-vitro, NA, IMR90
DNAdam↑, p‑γH2AX↑, Chk2↑, p38↑, Apoptosis↑,
497- MF,    In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells
- vitro+vivo, BC, MCF7 - vitro+vivo, Lung, A549
TumCG↓, TumVol↓, Casp3↑, Casp7↑, Apoptosis↑, DNAdam↑, TumCCA↑, ChemoSen↑, EPR↑,
501- MF,    Low Intensity and Frequency Pulsed Electromagnetic Fields Selectively Impair Breast Cancer Cell Viability
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
Apoptosis↑, *toxicity↓, ChemoSen↑, chemoP↑, selectivity↑, DNAdam↑,
2251- MF,  Rad,    BEMER Electromagnetic Field Therapy Reduces Cancer Cell Radioresistance by Enhanced ROS Formation and Induced DNA Damage
- in-vitro, Lung, A549 - in-vitro, HNSCC, UTSCC15 - in-vitro, CRC, DLD1 - in-vitro, PC, MIA PaCa-2
RadioS↑, DNAdam↑, ROS↑, ChemoSen∅, Pyruv↓, ADP:ATP↓, ROS↑,
8483- MF,    Magnetic Fields in Cancer Therapy: Mechanistic Insights, Signaling Pathways, and Evidence from Clinical and In Vitro Studies
- Review, Var, NA
Apoptosis↑, TumCP↓, Ferroptosis↑, TumCMig↓, EMT↓, ROS↝, ChemoSen↑, RadioS↑, Telomerase↓, selectivity↑, ROS↑, DNAdam↑, Casp↑, Ca+2↑, MMP↓, lysoMP↑, lipid-P↑, NA↑, other↑, ChemoSen↑, P53↑,
8486- MF,    Silent forces, hidden currents: the influence of static magnetic field stimulation on tumor biophysics
- Review, Var, NA
Ca+2↑, TumCG↓, MMP↓, CellMemb↑, SOX2↓, Nanog↓, cMyc↓, CD44↓, CD133↓, P53↑, ROS↑, DNAdam↑, CDK1↓, CycB/CCNB1↓, TumCCA↑, TumCP↓, pH↓, TumCP↓, Telomerase↓, ChemoSen↑, TRPV1↝, Bax:Bcl2↑, Casp3↑, Akt↓, mTOR↓, mitA↑, ROS↓, P-gp/ABCB1↓, MDR1↓, RadioS↑, Apoptosis↑, GSH↓, lipid-P↑, Iron↑, Iron↓, Fenton↑,
3464- MF,    Progressive Study on the Non-thermal Effects of Magnetic Field Therapy in Oncology
- Review, Var, NA
AntiTum↑, TumCG↓, TumCCA↑, Apoptosis↑, TumAuto↑, Diff↑, angioG↓, TumMeta↓, EPR↑, ChemoSen↑, ROS↑, DNAdam↑, P53↑, Akt↓, MAPK↑, Casp9↑, VEGFR2/KDR/Flk1↓, P-gp/ABCB1↓,
3468- MF,    An integrative review of pulsed electromagnetic field therapy (PEMF) and wound healing
- Review, Nor, NA
*other↑, *necrosis↓, *IL6↑, *TGF-β↑, *iNOS↑, *MMP2↑, *MCP1/CCL2↑, *HO-1↑, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *BioAv↑, eff⇅, DNAdam↑, Apoptosis↑, ROS↑, TumCP↓, *ROS↓, *FGF↑,
3486- MF,    Pulsed electromagnetic field potentiates etoposide-induced MCF-7 cell death
- in-vitro, BC, MCF-10AT
ChemoSen↑, tumCV↓, cl‑PARP↑, Casp7↑, Casp9↑, survivin↓, BAX↑, DNAdam↑, ROS↑, eff↓,
7382- MFrot,    Inhibition of mitochondrial NADH:ubiquinone oxidoreductase by spinning oscillating magnetic fields causes toxicity in cancer cells
- vitro+vivo, GBM, NA
ROS↑, compI↓, DNAdam↑, TumCCA↑, Casp↓, Apoptosis↑, mt-NADH↓, selectivity?, *toxicity?,
2259- MFrot,  MF,    Method and apparatus for oncomagnetic treatment
- in-vitro, GBM, NA
MMP↓, Bcl-2↓, BAX↑, Bak↑, Cyt‑c↑, Casp3↑, Casp9↑, DNAdam↑, ROS↑, lactateProd↑, Apoptosis↑, MPT↑, *selectivity↑, ChemoSen↑, MMP↓, selectivity↑, TCA?, H2O2↑, eff↑, *antiOx↑, H2O2↑, eff↓, GSH/GSSG↓, *toxicity∅, OS↑,
2258- MFrot,  MF,    EXTH-68. ONCOMAGNETIC TREATMENT SELECTIVELY KILLS GLIOMA CANCER CELLS BY INDUCING OXIDATIVE STRESS AND DNA DAMAGE
- in-vitro, GBM, GBM - in-vitro, Nor, SVGp12
TumVol↓, OS↑, γH2AX↑, DNAdam↑, selectivity↑, ROS↑, TumCD↑, eff↑, eff↓,
3493- MFrot,  MF,    Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes
- in-vivo, GBM, NA
TumCD↑, MMP↓, Cyt‑c↑, Apoptosis↑, OS↑, DNAdam↑,
8672- MLT,    Glioblastoma and Melatonin’s Effects: A Narrative Review
- Review, GBM, NA
selectivity↑, *ROS↓, *DNAdam↓, *SOD↑, *Catalase↑, *GPx↑, *Inflam↓, *EGF↓, *HIF-1↓, Pyruv↓, Glycolysis↓, ROS↑, TumCG↓, IL1β↓, ICAM-1↓, VCAM-1↓, NRF2↓, RadioS↑, OS↑, NAD↓, LDHA↓, MCT4↓, pH↝, ChemoSen↑, Synergy↑, TRPV1↓, Pain↓, Synergy↑, Dose↑,
3844- MO,    Review of the Safety and Efficacy of Moringa oleifera
- Review, Nor, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,
8912- MO,    Anticancer effect of Moringa oleifera in oral squamous cell carcinoma: a systematic review
- Review, Oral, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *chemoPv↑, *Ingr↝, *AntiDiabetic↑, *hepatoP↑, *Bacteria↓, *AntiFungal↑, Apoptosis↑, ROS↑, DNAdam↑, Casp3↑, TumCCA↑, ROS↓, chemoP↑,
8867- MOR,  doxoR,    Morin Sensitizes MDA-MB-231 Triple-Negative Breast Cancer Cells to Doxorubicin Cytotoxicity by Suppressing FOXM1 and Attenuating EGFR/STAT3 Signaling Pathways
- in-vitro, BC, MDA-MB-231
ChemoSen↑, EPR↑, DNAdam↑, γH2AX↑, p‑EGFR↓, p‑STAT3↓, TumCCA↑, P21↑, cycD1/CCND1↓, FOXM1↓, tumCV↓, *p38↑,
8886- MOR,  doxoR,    Morin overcomes doxorubicin resistance in human breast cancer by inducing DNA damage and modulating the LKB1/AMPK/mTORC1 signaling pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
DNAdam↑, DNArepair↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, CycB/CCNB1↓, PARP↓, Bcl-xL↓, p‑AMPK↑, p‑STK11/LKB1↑, p‑mTOR↓, p‑Akt↓, p‑GSK‐3β↓, tumCV↓,
8920- MP,    Therapeutic peptides of Mucuna pruriens L.: Anti‐genotoxic molecules against human hepatocellular carcinoma and hepatitis C virus
- in-vitro, Liver, HepG2 - in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, QGY-7703
TumCD↑, Dose↝, *DNAdam↓,
8918- MP,  Cisplatin,    Mucuna pruriens (L.) DC chemo sensitize human breast cancer cells via downregulation of prolactin-mediated JAK2/STAT5A signaling
- in-vitro, BC, T47D - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-231
Dose?, TumCP↓, DNAdam↑, TumCCA↑, PRL↓, JAK2↓, STAT5↓, cycD1/CCND1↓, ChemoSen↑,
8772- MSM,  doxoR,    Methylsulfonylmethane sensitizes endometrial cancer cells to doxorubicin
- in-vitro, EC, NA
Apoptosis↑, ChemoSen↑, DNAdam↑, tumCV↓, ROS↑,
8804- MT/VAE,    Activation of caspase cascades in Korean mistletoe (Viscum album var. coloratum) lectin-II-induced apoptosis of human myeloleukemic U937 cells
- in-vitro, lymphoma, U937
DNAdam↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, cl‑PKCδ↑, Apoptosis↑,
4036- NAD,  VitB3,    NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
- in-vivo, AD, NA
*Inflam↓, *p‑tau↓, *DNAdam↓, *memory↑, *motorD↑, *cognitive↑, *BBB↑, IL1β↓, *TNF-α↓, *MCP1/CCL2↓, *RANTES↓, *ROS↓, *SIRT3↑, *SIRT6↑,
4035- NAD,  VitB3,    NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING
- in-vitro, AD, NA
*Inflam↓, *DNAdam↓, *NLRP3↓, *cGAS–STING↓,
2933- NAD,    Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns
- Review, Nor, NA - NA, AD, NA - NA, Diabetic, NA - NA, Stroke, NA - NA, LiverDam, NA - NA, Park, NA
*mtDam↓, *BioAv↝, *BioAv↑, *OS↑, *eff↑, *eff↑, *cognitive↑, *DNAdam↓, *SIRT1↑, *cardioP↑, *ROS↓, *Dose↝, *BioAv↑, *hepatoP↑, *eff↑, *BG↓, *creat↓,
2936- NAD,    The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
- Review, Nor, NA
*ROS↓, *DNAdam↓, *neuroP↑, *Inflam↓, *BioAv↑, *SIRT1↑, BioAv↝,
2939- NAD,  Rad,    NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7
- in-vitro, Nor, NA
*SIRT6↑, *DNAdam↓, *radioP↑, *ROS↓,
6489- Nimb,    Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model
- in-vivo, Pca, DU145 - in-vivo, Pca, LNCaP
tumCV↓, Apoptosis↑, TumCI↓, TumCMig↓, STAT3↓, ROS↑, TumCG↓, TumMeta↓, TumCCA↑, DNAdam↑, Casp3↑, Casp7↑, cl‑PARP↑, p‑STAT3↓, IL6↓, GSR↓,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
4973- Nimb,    Nimbolide Exhibits Potent Anticancer Activity Through ROS-Mediated ER Stress and DNA Damage in Human Non-small Cell Lung Cancer Cells
- in-vitro, NSCLC, A549
tumCV↓, ROS↑, ER Stress↑, DNAdam↑, Apoptosis↑, eff↓,
8426- OM,    Origanum majorana Ethanolic Extract Promotes Colorectal Cancer Cell Death by Triggering Abortive Autophagy and Activation of the Extrinsic Apoptotic Pathway
- in-vitro, CRC, HT-29 - in-vitro, Colon, Caco-2
TumCP↓, tumCV↓, mitA↑, DNAdam↑, Casp3↑, Casp7↑, survivin↓, TumAuto↑,
8435- OM,  Aroma,    Memory-Enhancing Effects of Origanum majorana Essential Oil in an Alzheimer's Amyloid beta1-42 Rat Model: A Molecular and Behavioral Study
- in-vivo, AD, NA
*Dose?, *antiOx↑, *BDNF↑, *cognitive↑, *AntiViral↑, *AChE↝, *TumMeta↓, *TumCG↓, *Ingr↝, *DNAdam↓, *ROS↓, *MDA↓, *memory↑,
8427- OM,    Mitotic arrest and apoptosis in breast cancer cells induced by Origanum majorana extract: upregulation of TNF-α and downregulation of survivin and mutant p53
- in-vitro, BC, MDA-MB-231
tumCV↓, Dose↝, mitA↑, Apoptosis↑, TNF-α↑, Casp3↑, Casp8↑, cl‑PARP↑, survivin↓, p53 Wildtype↓, P21↑, ac‑H3↑, ac‑H4↑, γH2AX↑, DNAdam↑, TumCCA↑,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
1680- PBG,    Protection against Ultraviolet A-Induced Skin Apoptosis and Carcinogenesis through the Oxidative Stress Reduction Effects of N-(4-bromophenethyl) Caffeamide, a Propolis Derivative
- in-vitro, Nor, HS68
*ROS↓, *NRF2↑, *HO-1↑, *cJun↓, *MMP1↓, *MMP2↓, *p‑cJun↓, *cFos↓, *BAX↓, *Casp3↓, *DNAdam↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *PGE2↓, *NO↓,
1666- PBG,    Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
- Review, Var, NA
ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2/PTGS2↑, ER(estro)↓, cycA1/CCNA1↓, CycB/CCNB1↓, CDK2↓, P21↑, p27/CDKN1B↑, hTERT/TERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,
1663- PBG,    Propolis and Their Active Constituents for Chronic Diseases
- Review, Var, NA
NF-kB↓, Casp↓, Fas↓, DNAdam↑, Casp3↑, P53↝, MMP↝, ROS↑, mtDam↑, Dose?, angioG↓, TumCP↓, TumCMig↓, BAX↑, selectivity↑, MMP↓, LDH↓, IL6↓, IL1β↓, TNF-α↓,

Showing Research Papers: 301 to 350 of 452
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 452

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 2,   antiOx↑, 10,   Catalase↓, 7,   Catalase↑, 3,   Catalase∅, 1,   cystine↓, 1,   Fenton↑, 8,   GPx↓, 2,   GPx↑, 4,   GPx4↓, 5,   GSH↓, 30,   GSH↑, 5,   GSH∅, 1,   mt-GSH↓, 1,   GSH/GSSG↓, 5,   GSR↓, 2,   GSR↑, 2,   GSSG↑, 1,   ox-GSSG↑, 1,   GSTs↓, 2,   GSTs∅, 1,   H2O2↓, 1,   H2O2↑, 14,   HO-1↓, 7,   HO-1↑, 7,   HO-2↓, 1,   HO-2↑, 1,   Iron↓, 1,   Iron↑, 4,   c-Iron↑, 1,   lipid-P↓, 4,   lipid-P↑, 19,   lipid-P↝, 1,   MDA↓, 2,   MDA↑, 3,   i-MDA↑, 1,   mt-NADH↓, 1,   NADPH/NADP+↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 12,   NRF2↑, 12,   Prx4↑, 1,   PrxII↓, 1,   ROS↓, 22,   ROS↑, 253,   ROS⇅, 4,   ROS↝, 1,   i-ROS↓, 1,   i-ROS↑, 3,   m-ROS↑, 1,   mt-ROS↑, 6,   SOD↓, 6,   SOD↑, 5,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   TAC?, 1,   TBARS↓, 1,   TBARS↑, 1,   Thiols↓, 1,   Trx↓, 4,   Trx↑, 1,   Trx1↓, 1,   Trx2↓, 1,   TrxR↓, 10,   TrxR1↓, 2,   TrxR1⇅, 1,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 1,   NCOA4↑, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   ADP:ATP↑, 1,   BCR↓, 1,   CDC2↓, 3,   CDC25↓, 10,   CDC25↝, 1,   compI↓, 2,   EGF↓, 3,   ETC↓, 2,   ETC↝, 1,   Insulin↓, 2,   mitResp↓, 2,   MKK7↓, 1,   mtDam↓, 1,   mtDam↑, 19,   OCR↓, 1,   mt-OCR↓, 1,   OXPHOS↓, 3,   OXPHOS↑, 2,   PDH↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   ACC↑, 2,   ACLY↓, 1,   ACSL4↑, 2,   ALAT↓, 3,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 17,   p‑AMPK↑, 2,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 22,   ATP↑, 1,   CRM↑, 1,   ECAR↓, 1,   ECAR↝, 1,   p‑ENO1↓, 1,   FASN↓, 2,   G6PD∅, 1,   GAPDH↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 7,   GlucoseCon∅, 1,   Glycolysis↓, 21,   GSK‐3β↓, 6,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 4,   H2S↑, 1,   Histones↑, 2,   HK2↓, 8,   lactateProd↓, 9,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 6,   LDL↓, 2,   MCT4↓, 1,   NAD↓, 5,   NADPH↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 6,   p‑PDK1 / PDPK1↓, 1,   PKM2↓, 7,   PPP↓, 1,   Pyruv↓, 2,   Pyruv↑, 1,   p‑S6↓, 1,   SIRT1↓, 4,   SIRT1↑, 6,   SIRT2↓, 1,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 17,   APAF1↑, 6,   Apoptosis↓, 6,   Apoptosis↑, 208,   mt-Apoptosis↑, 4,   BAD↓, 1,   BAD↑, 8,   Bak↑, 4,   BAX?, 1,   BAX↓, 2,   BAX↑, 74,   Bax:Bcl2↑, 26,   Bcl-2↓, 74,   Bcl-2↑, 2,   Bcl-xL↓, 13,   Bcl-xL↑, 1,   BID↑, 3,   p‑BID↓, 1,   cl‑BID↑, 2,   BIM↑, 5,   Casp↓, 2,   Casp↑, 33,   Casp3↓, 3,   Casp3↑, 129,   cl‑Casp3↑, 19,   proCasp3↑, 1,   pro‑Casp3↑, 2,   Casp6↑, 1,   Casp7↑, 20,   cl‑Casp7↑, 2,   Casp8↑, 28,   cl‑Casp8↑, 3,   proCasp8↑, 1,   Casp9?, 1,   Casp9↑, 71,   cl‑Casp9↑, 11,   proCasp9↑, 1,   pro‑Casp9↑, 1,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 64,   Diablo↑, 8,   DR5↑, 6,   Endon↑, 2,   FADD↑, 2,   Fap1↓, 1,   Fas↓, 2,   Fas↑, 13,   FasL↑, 5,   Ferroptosis↑, 8,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 8,   JWA↑, 1,   Mcl-1↓, 8,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 4,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 4,   Necroptosis↑, 5,   necrosis↑, 6,   NOXA↑, 2,   oncosis↑, 1,   p38↓, 4,   p38↑, 13,   p‑p38↑, 2,   Paraptosis↑, 2,   PUMA↑, 4,   RIP3↑, 2,   p‑RIP3↑, 2,   survivin↓, 23,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↑, 32,   XIAP↓, 11,   YAP/TEAD↓, 1,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 81,   Akt↑, 2,   p‑Akt↓, 17,   p‑Akt↑, 2,   Akt2↓, 1,   CK2↓, 2,   cMET↓, 1,   cSrc↓, 1,   DDIT4↑, 1,   EGFR↓, 18,   p‑EGFR↓, 1,   ERK↓, 31,   ERK↑, 4,   p‑ERK↓, 5,   p‑ERK↑, 2,   FGFR1↓, 2,   FGFR2↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   HRAS↓, 1,   IKKα↓, 2,   p‑IKKα↓, 1,   JAK↓, 5,   p‑JAK↓, 1,   JAK1↓, 4,   JAK1↑, 1,   JAK2↓, 7,   JNK↓, 4,   JNK↑, 13,   p‑JNK↑, 2,   MAPK↓, 23,   MAPK↑, 10,   MAPK↝, 1,   MARK4↓, 1,   MEK↓, 3,   MKK4↓, 1,   mTOR↓, 41,   mTOR↑, 2,   mTOR⇅, 1,   p‑mTOR↓, 1,   mTORC2↓, 2,   NRAS↓, 1,   p70S6↓, 2,   p‑p70S6↑, 1,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   PI3K↓, 47,   PI3K↑, 4,   p‑PI3K↓, 1,   PI3K/Akt↓, 1,   PIK3CA↓, 1,   PKCδ↓, 9,   cl‑PKCδ↑, 1,   PTEN↓, 1,   PTEN↑, 13,   Raf↓, 4,   RAS↓, 6,   RIP1↑, 1,   p‑S6K↓, 2,   Sp1/3/4↓, 6,   STAT↓, 3,   p‑STAT↓, 1,   STAT3↓, 34,   STAT3↑, 2,   p‑STAT3↓, 6,   p‑STAT3↑, 1,   STAT5↓, 4,   STAT6↓, 1,   p‑STK11/LKB1↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ATF4↑, 5,   ATF4↝, 1,   ATFs↑, 1,   CBP↓, 1,   ChrMod↑, 1,   cJun↓, 7,   cJun↑, 1,   cMyc↓, 23,   p‑cMyc↑, 1,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 1,   EZH2↓, 1,   FOXM1↓, 3,   FOXO↓, 1,   FOXO↑, 1,   FOXO3↑, 1,   FOXO3↝, 1,   FOXO4↑, 2,   ac‑H3↑, 3,   H3K18↓, 1,   ac‑H4↑, 2,   HATs↓, 2,   HDAC↓, 7,   HDAC1↓, 3,   HDAC2↓, 2,   HDAC3↓, 1,   HDAC8↓, 1,   miR-21↓, 2,   miR-210↓, 1,   miR-218↑, 1,   miR-27a-3p↓, 1,   miR-590-3p↑, 1,   Myc↓, 4,   n-MYC↓, 1,   OCT4↓, 7,   other↓, 1,   other↑, 9,   other↝, 9,   OV6↓, 1,   PhotoS↑, 2,   SOX2↓, 5,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   TCF-4↓, 2,   tumCV?, 1,   tumCV↓, 58,   tumCV∅, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   cl‑ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 12,   eIF2α↑, 2,   p‑eIF2α↓, 1,   p‑eIF2α↑, 2,   ER Stress↓, 2,   ER Stress↑, 35,   GRP78/BiP?, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 12,   HSF1↓, 1,   HSP27↓, 3,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   IRE1↑, 4,   NPL4↓, 1,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 10,   XBP-1↓, 1,   XBP-1↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 2,   ATG5↑, 2,   ATG7↑, 1,   autoF↓, 1,   AVOs↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 8,   CTSB↓, 1,   CTSD↓, 1,   LAMP2↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 2,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↓, 2,   LC3II↑, 3,   LC3s↝, 1,   lysoMP↑, 2,   lysosome↝, 1,   MitoP↑, 1,   p62↓, 5,   p62↑, 3,   SESN2↑, 2,   TumAuto↓, 1,   TumAuto↑, 28,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 6,   p‑ATM↑, 1,   ATR↑, 3,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   DFF45↓, 1,   DNAdam↓, 14,   DNAdam↑, 377,   mt-DNAdam↑, 2,   DNArepair↓, 3,   FEN1↓, 2,   HR↓, 1,   hTERT/TERT↓, 6,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   NHEJ↓, 1,   p16↑, 2,   P53↓, 3,   P53↑, 67,   P53↝, 3,   p‑P53↑, 5,   p53 Wildtype↓, 1,   PARP↓, 3,   PARP↑, 13,   p‑PARP↑, 1,   cl‑PARP↓, 3,   cl‑PARP↑, 56,   cl‑PARP↝, 1,   PARP1↑, 3,   PCNA↓, 21,   RAD51↓, 1,   SIRT6↑, 1,   Telomerase↓, 10,   TOP1↓, 6,   TOP1∅, 1,   TOP2↓, 8,   TP53↑, 2,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 25,   p‑γH2AX↑, 6,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 6,   CDK1↑, 3,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK2↓, 24,   CDK2↑, 1,   CDK4↓, 26,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 11,   CDK6↑, 2,   CDK8↓, 1,   CHK1↓, 4,   CHK1↑, 2,   CHK1↝, 1,   p‑CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 5,   p‑Chk2↑, 1,   ChrCon↑, 3,   Cyc↓, 1,   cycA1/CCNA1↓, 6,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 2,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 54,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 19,   cycE1↓, 2,   E2Fs↓, 2,   E2Fs↑, 1,   GADD45A↑, 2,   Ki-67↓, 12,   mitA↑, 3,   P21↓, 3,   P21↑, 55,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 20,   RB1↓, 1,   p‑RB1↓, 4,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 3,   TumCCA↑, 166,   TumCCA∅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 7,   ALDH1A1↓, 2,   ALDH1A3↓, 1,   CD133↓, 7,   CD133↑, 1,   cFos↓, 7,   CSCs↓, 34,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 4,   FGF↓, 1,   Gli1↓, 4,   HH↓, 2,   IGF-1↓, 5,   IGF-2↓, 1,   IGFBP3↑, 1,   IGFBP7↑, 1,   Ki-67↓, 12,   mTORC1↓, 3,   p‑mTORC1↓, 1,   Nanog↓, 7,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 5,   NOTCH⇅, 1,   NOTCH1↓, 7,   NOTCH1↑, 2,   NOTCH2↓, 1,   p300↓, 1,   PTCH1↓, 3,   SCF↓, 1,   Shh↓, 2,   Smo↓, 3,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 63,   TumCG↑, 1,   TumCP↓, 97,   TumCP↑, 2,   tyrosinase↓, 1,   Wnt↓, 20,   Wnt/(β-catenin)↓, 5,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↑, 1,   AP-1↓, 6,   APC↑, 1,   AXL↓, 1,   Ca+2↓, 2,   Ca+2↑, 26,   Ca+2↝, 1,   i-Ca+2↑, 1,   cal2↓, 1,   CCN2/CTGF↓, 1,   CD11b↑, 1,   Cdc42↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 17,   EMT↓, 33,   EMT↑, 1,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 4,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 3,   GLI2↓, 2,   ITGB1↑, 1,   KRAS↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 42,   MMP3↓, 4,   MMP7↓, 6,   MMP9↓, 43,   MMPs↓, 10,   MUC4↓, 1,   N-cadherin↓, 11,   NCAM↑, 1,   NEDD9↓, 1,   PDGF↓, 1,   RECK↑, 1,   Slug?, 1,   Slug↓, 4,   p‑SMAD2↓, 1,   SMAD3↓, 3,   p‑SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 7,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 4,   TGF-β↓, 11,   TGF-β↑, 1,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 7,   TRIB3↑, 1,   TSC1↑, 1,   TumCA↓, 2,   TumCI↓, 34,   TumCMig↓, 37,   TumMeta↓, 42,   TumMeta↑, 1,   Twist↓, 5,   TXNIP↑, 1,   uPA↓, 8,   Vim↓, 14,   Zeb1↓, 2,   α-SMA↓, 1,   β-catenin/ZEB1↓, 21,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 54,   angioG↑, 2,   CD31/PECAM-1↓, 1,   Endoglin↑, 2,   eNOS↓, 2,   HIF-1↓, 4,   Hif1a↓, 29,   Hif1a↑, 1,   Hypoxia↓, 2,   LOX1↓, 2,   NO↓, 4,   NO↑, 5,   VCAM-1↓, 3,   VEGF↓, 51,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   CellMemb↑, 4,   CLDN1↓, 1,   CTR1↑, 2,   EPR↑, 11,   GLUT1↓, 5,   GLUT2↓, 1,   MMP↓, 115,   MMP↑, 2,   MMP↝, 1,   MPT↓, 1,   MPT↑, 4,   NHE1↓, 1,   SVCT-2↝, 1,   SVCT-2∅, 1,   TRPM7↓, 2,   TRPV1↓, 1,   TRPV1↑, 1,   TRPV1↝, 1,   VGCC↑, 1,   VGSC↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD44↓, 8,   CD47↓, 1,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 34,   COX2/PTGS2↑, 2,   CXCL12↓, 1,   CXCR4↓, 7,   DR4↑, 1,   FOXP3↑, 1,   HMGB1↓, 3,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   Igs↑, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 1,   IL12↓, 1,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 8,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 2,   IL4↓, 2,   IL4↑, 1,   IL6↓, 22,   IL8↓, 3,   Imm↑, 13,   Inflam↓, 19,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   Neut↓, 1,   NF-kB↓, 65,   NF-kB↑, 7,   NF-kB↝, 1,   p‑NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 1,   NLRP3↑, 1,   p65↓, 3,   PD-L1↓, 2,   PD-L1↑, 1,   PGE2↓, 14,   PSA↓, 2,   TCF↓, 1,   TCF↑, 1,   TLR4↓, 3,   TNF-α↓, 17,   TNF-α↑, 4,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   pH↑, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 7,   AR-V7?, 1,   CYP19?, 1,   ER-α36↓, 1,   ER(estro)↓, 1,   PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 2,   PRL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 20,   BioAv↑, 24,   BioAv↝, 5,   BioEnh↑, 3,   CBR1↓, 1,   chemoR↓, 2,   ChemoSen↓, 2,   ChemoSen↑, 114,   ChemoSen⇅, 1,   ChemoSen↝, 1,   ChemoSen∅, 1,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   DDS↑, 1,   Dose?, 6,   Dose↓, 5,   Dose↑, 7,   Dose↝, 34,   Dose∅, 10,   DrugR↓, 1,   eff↓, 48,   eff↑, 88,   eff⇅, 1,   eff↝, 12,   GSTA1↑, 2,   Half-Life↓, 5,   Half-Life↝, 5,   MDR1↓, 8,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 13,   P450↓, 2,   RadioS↓, 1,   RadioS↑, 59,   selectivity?, 2,   selectivity↓, 2,   selectivity↑, 99,   selectivity↝, 1,   Synergy↑, 62,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 3,   ALP↓, 1,   AR↓, 7,   AST↓, 1,   BG↓, 2,   BloodF↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 18,   p‑EGFR↓, 1,   EZH2↓, 1,   Ferritin↓, 2,   FOXM1↓, 3,   HER2/EBBR2↓, 7,   hTERT/TERT↓, 6,   IL6↓, 22,   KRAS↓, 1,   LDH↓, 6,   LDH↑, 2,   LDH↝, 1,   Myc↓, 4,   PD-L1↓, 2,   PD-L1↑, 1,   PSA↓, 2,   TP53↑, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 2,   AntiCan↑, 42,   AntiCan∅, 1,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 11,   cachexia↓, 1,   cardioP↑, 4,   chemoP↑, 17,   chemoPv↑, 6,   ChemoSideEff↓, 5,   hepatoP↑, 4,   K17↓, 1,   LC↑, 1,   neuroP↑, 3,   NKG2D↑, 1,   NP/CIPN↓, 1,   NP/CIPN↝, 1,   OS↑, 13,   Pain↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 4,   radioP↑, 7,   RenoP↑, 4,   Risk↓, 10,   Strength↑, 1,   toxicity↓, 11,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 13,   TumW↓, 4,   Weight↑, 2,   Weight∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 5,   Sepsis↓, 2,  
Total Targets: 831

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5,   antiOx↑, 57,   Bil↓, 1,   Catalase↑, 28,   DPPH↓, 1,   Fenton↓, 1,   GPx↑, 21,   GPx1↑, 2,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 24,   GSR↑, 2,   GSTs↑, 9,   H2O2↓, 1,   H2O2↑, 1,   HDL↓, 1,   HDL↑, 4,   HO-1↑, 17,   Keap1↓, 1,   lipid-P↓, 22,   lipid-P↑, 1,   MDA↓, 20,   MPO↓, 3,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2↑, 20,   p‑NRF2↑, 1,   Prx↑, 1,   RNS↓, 3,   ROS?, 1,   ROS↓, 75,   ROS↑, 3,   ROS∅, 4,   selenoP↑, 5,   SOD↓, 2,   SOD↑, 31,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 2,   Trx1↑, 1,   uricA↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

EGF↓, 1,   FIS1↓, 1,   mtDam↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 4,   ACC↓, 1,   ALAT↓, 7,   AMPK↑, 2,   Buty↑, 1,   DGAT1↓, 1,   FASN↓, 2,   glucose↓, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 2,   HMG-CoA↓, 1,   LDL↓, 6,   lipidLev↓, 1,   NADPH↓, 1,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 5,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 6,   BAX↓, 7,   Bax:Bcl2↓, 1,   Bcl-2↑, 5,   Bcl-xL↑, 1,   Casp↓, 1,   Casp3↓, 7,   cl‑Casp3↓, 1,   Casp9↓, 2,   Cyt‑c↓, 2,   iNOS↓, 10,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 2,   p38↑, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   ERK↓, 2,   ERK↑, 3,   IκB?, 1,   JAK2↓, 1,   JAK2↑, 1,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 2,   PI3K↓, 1,   PI3K↑, 1,   PKCδ↑, 1,   STAT3↓, 2,   STAT3↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 2,   p‑cJun↓, 1,   p‑cMyc↑, 1,   HDAC↓, 2,   HDAC3↓, 1,   other↓, 4,   other↑, 4,   other↝, 3,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 2,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

CTSZ↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 63,   DNAdam↑, 3,   DNAdam∅, 1,   DNArepair↑, 2,   SIRT6↑, 2,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cellSen↓, 1,   Ki-67↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↓, 1,   FGF↑, 1,   Ki-67↓, 2,   TumCG↓, 1,   TumCP↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   Ca+2↓, 3,   Ca+2↝, 1,   COL1↓, 1,   COL1↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   LRP1↑, 1,   MMP1↓, 1,   MMP2↓, 1,   MMP2↑, 2,   MMP3↓, 1,   MMP9↓, 1,   MUC1↑, 1,   ROCK1↓, 2,   Snail↑, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,   Twist↑, 1,   Vim↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   HIF-1↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO↓, 5,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 7,   GastroP↑, 3,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 2,   MMP↑, 3,   MUC19↓, 1,   MUC2↓, 1,   TJ↑, 1,   VGCC↝, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD25+↑, 1,   CD4+↑, 2,   cGAS–STING↓, 2,   COX1↓, 2,   COX2/PTGS2↓, 16,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 2,   IL10↑, 5,   IL17↓, 3,   IL1α↓, 1,   IL1β↓, 9,   IL2↓, 1,   IL22↓, 2,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 19,   IL6↑, 1,   IL8↓, 1,   Imm↑, 4,   Inflam↓, 70,   Inflam↑, 1,   IRF3↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 4,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 1,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 19,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 4,   PGE2↓, 8,   PGE2↑, 1,   RAGE↓, 2,   RANTES↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR1↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 23,   TNF-α↑, 1,   Treg lymp↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 6,   AChE↑, 1,   AChE↝, 1,   BChE↓, 2,   BDNF↑, 6,   GABA↑, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   Aβ↓, 7,   BACE/β-secretase↓, 2,   tau↓, 2,   p‑tau↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GLP-1R↑, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 17,   BioAv↑, 25,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↑, 2,   CompStab↑, 1,   CompStab↝, 1,   CYP2E1↓, 1,   Dose?, 2,   Dose↓, 2,   Dose↑, 2,   Dose↝, 19,   Dose∅, 1,   eff↓, 1,   eff↑, 16,   eff↝, 1,   Half-Life↓, 2,   Half-Life↝, 2,   Half-Life∅, 1,   P450↓, 1,   P450↑, 1,   RadioS↑, 1,   selectivity↑, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALB↑, 1,   ALB↝, 1,   ALP↓, 3,   AST↓, 8,   BG↓, 1,   Bil↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 5,   BUN↓, 2,   creat↓, 3,   CRP↓, 4,   HOMA↓, 1,   hs-CRP↓, 1,   IL6↓, 19,   IL6↑, 1,   LDH↓, 2,   NOS2↓, 1,   RAGE↓, 2,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 6,   AntiArt↑, 4,   AntiCan↑, 13,   AntiDiabetic↑, 16,   AntiTum↑, 1,   Bone Healing↑, 1,   cardioP↑, 19,   CardioT↓, 1,   chemoP↑, 4,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 10,   diuretic↑, 2,   hepatoP↑, 20,   memory↑, 11,   Mood↑, 1,   motorD↑, 2,   neuroP↓, 1,   neuroP↑, 27,   Obesity↓, 4,   OS↑, 3,   Pain↓, 3,   PDE4↓, 1,   QoL↑, 1,   radioP↑, 11,   RenoP↑, 7,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 1,   toxicity?, 2,   toxicity↓, 27,   toxicity↝, 6,   toxicity∅, 6,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 4,   AntiViral↑, 5,   Bacteria↓, 15,   Diar↓, 1,   GutMicro↑, 8,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 4,  
Total Targets: 339

Scientific Paper Hit Count for: DNAdam, DNA damage
33 Silver-NanoParticles
19 Radiotherapy/Radiation
17 Vitamin C (Ascorbic Acid)
14 Magnetic Fields
12 Curcumin
11 Fisetin
9 Cisplatin
8 Quercetin
8 Lycopene
7 Chemotherapy
7 Ashwagandha(Withaferin A)
7 doxorubicin
7 Chrysin
7 salinomycin
7 Selenium NanoParticles
7 Sulforaphane (mainly Broccoli)
6 Artemisinin
6 Apigenin (mainly Parsley)
6 Berberine
6 Carvacrol
6 Emodin
6 Piperlongumine
5 Copper and Cu NanoParticles
5 Allicin (mainly Garlic)
5 Baicalein
5 Betulinic acid
5 Ellagic acid
5 diet FMD Fasting Mimicking Diet
5 Dandelion Root
5 Gallic acid
5 Kaempferol
5 nicotinamide adenine dinucleotide
5 Selenite (Sodium)
5 Thymoquinone
4 Auranofin
4 Beta-Caryophyllene
4 Capsaicin
4 Thymol-Thymus vulgaris
4 Echinacea
4 Electrical Pulses
4 Ferulic acid
4 Garcinol
4 Licorice
4 Magnolol
4 Magnetic Field Rotating
4 Vitamin B3,Niacin
4 Propolis -bee glue
4 Resveratrol
4 Shikonin
3 chitosan
3 Moringa oleifera
3 Anethole/trans-Anethole
3 Melatonin
3 borneol
3 Boron
3 Boswellia (frankincense)
3 Rosmarinic acid
3 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
3 Cat’s Claw
3 Cynaropicrin
3 Disulfiram
3 EGCG (Epigallocatechin Gallate)
3 Eurycomanone
3 Eugenol
3 Hibiscus sabdariffa
3 Juglone
3 Lemongrass Extract/Citral
3 Lutein
3 mebendazole
3 Nimbolide
3 Marjoram (Origanum majorana)
3 Phenethyl isothiocyanate
3 Phycocyanin
3 α-Santalol/Sandalwood oil
3 Selenium
3 Silymarin (Milk Thistle) silibinin
3 Vitamin K2
2 1,8-Cineole
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Metformin
2 Astaxanthin
2 Aloe anthraquinones
2 brusatol
2 Bruteridin(bergamot juice)
2 Caffeic acid
2 Carnosic acid
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Crocetin
2 diet Short Term Fasting
2 Fucoidan
2 Gambogic Acid
2 Geraniol
2 γ-linolenic acid (Borage Oil)
2 Grapeseed extract
2 Hydrogen Gas
2 Hydroxycinnamic-acid
2 isoorientin
2 methylseleninic acid
2 Morin
2 Mucuna pruriens/Velvet Bean
2 Propyl gallate
2 Ursolic acid
2 VitK3,menadione
1 3-bromopyruvate
1 5-Hydroxytryptophan
1 Astragalus
1 Gold NanoParticles
1 Photodynamic Therapy
1 entinostat
1 tamoxifen
1 Alpha-Lipoic-Acid
1 Fennel Oil/Foeniculum vulgare
1 Ascorbyl Palmitate
1 Baicalin
1 Biochanin A
1 Gemcitabine (Gemzar)
1 Bromelain
1 Black phosphorus
1 α-Bisabolol / Chamomile oil
1 buckwheat sprouts
1 Rutin
1 Zinc
1 carboplatin
1 Catechins
1 chaetocin
1 Chlorophyllin
1 Cinnamon
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 chemodynamic therapy
1 Dichloroacetate
1 Deguelin
1 Diclofenac
1 Date Fruit Extract
1 D-limonene
1 immunotherapy
1 Butyrate
1 Sesame seeds and Oil
1 Formononetin
1 Flaxseed/Linseed
1 Flaxseed Oil
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 olaparib/LYNPARZA
1 Galloflavin
1 Germanium inorganic
1 Ginkgetin
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 Honokiol
1 Hyperthermia
1 HydroxyTyrosol
1 Isobavachalcone
1 isoquercitrin
1 Lapachol
1 Lasiodin
1 Linalool
1 Luteolin
1 MCT, metronomic chemo
1 Methyl salicylate / Sweet Birch oil
1 Methylsulfonylmethane
1 Mistletoe/Viscum album Extracts
1 Aromatherapy
1 5-fluorouracil
1 Piperine
1 Plumbagin
1 Rauwolfia serpentina/Indian Snakeroot
1 Sulfasalazine
1 Aflavin-3,3′-digallate
1 temozolomide
1 triptolide
1 Urolithin
1 Iron
1 Magnesium
1 Vitexin
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:82  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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