DNAdam Cancer Research Results

DNAdam, DNA damage: Click to Expand ⟱

Source: HalifaxProj(prevent)

Type:

DNA damage plays a crucial role in the development of cancer. The integrity of DNA is essential for the proper functioning of cells, and when DNA is damaged, it can lead to mutations that may contribute to cancer progression.

Scientific Papers found: Click to Expand⟱

629-

VitC,

Cu,

Fe,

The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant breakage of cellular DNA: implications for chemotherapeutic action against cancer

-

in-vitro,

NA,

NA

ROS↑, DNAdam↑, NAD↓,

628-

VitC,

Mg,

Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation

-

in-vivo,

Colon,

CT26

mouse

-

in-vitro,

NA,

MCF-7

 1–10 mM(Mg)

(MgSO4 and MgCl2) no cytotoxicity at any of the tested concentrations.

-

in-vitro,

NA,

SkBr3

AntiCan↑, SVCT-2↝, TumCD↑, ROS↑, P21↑, proCasp3↑, TumVol↓, DNAdam↑, NAD↓,

3138-

VitC,

The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity

-

in-vitro,

RCC,

RCC4

-

in-vitro,

CRC,

HCT116

-

in-vitro,

BC,

MDA-MB-435

-

in-vitro,

Ovarian,

SKOV3

-

in-vitro,

Colon,

SW48

-

in-vitro,

GBM,

U251

eff↑, Warburg↓, BioAv↑, ROS↑, DNAdam↑, ATP↓, eff↑, necrosis↑, PARP↑,

3109-

VitC,

Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway

-

in-vitro,

Lung,

H1299

TumMeta↓, NRF2↑, HO-1↑, cl‑Casp3↑, cl‑Casp9↑, DNAdam↑, Apoptosis↑, other↑, selectivity↑,

3104-

VitC,

Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations

*antiOx↑, *ROS↓, *DNAdam↓, ROS↑, TET1↑, CSCs↓, HIF-1↓, BioAv↑, selectivity↑,

3128-

VitC,

Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages

-

in-vitro,

Nor,

NA

*ROS↓, *DNAdam↓, *TNF-α↓, *IL6↓, *p38↓,

1819-

VitC,

VitK3,

The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy

-

Review,

Var,

NA

Dose?, TumCD↑, selectivity↑, H2O2↑, ROS↑, DNAdam↑,

2284-

VitK2,

Menadione-induced DNA damage in a human tumor cell line

-

in-vitro,

BC,

MCF-7

DNAdam↑, ROS↑,

2276-

VitK2,

Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat

-

in-vivo,

Nor,

NA

rat

*Albumin↑, *AST↓, *ALAT↓, *Keap1↓, *NRF2↑, *HO-1↑, *COX2↓, *iNOS↓, *TNF-α↓, *TIMP1↓, *TGF-β↓, *ROS↓, *DNAdam↓, *Inflam↓,

1824-

VitK2,

Vitamin K and its analogs: Potential avenues for prostate cancer management

-

Review,

Pca,

NA

AntiCan↑, toxicity∅, Risk↓, Apoptosis↑, ROS↑, TumCCA↑, eff↑, DNAdam↑, MMP↓, Cyt‑c↑, pro‑Casp3↑, FasL↑, Fas↑, TumAuto↑, ChemoSen↑, RadioS↑,

1832-

VitK3,

VitC,

Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism

-

in-vitro,

AML,

K562

ROS↑, H2O2↑, NF-kB↑, P53↑, cJun↑, Casp3↑, MMP↓, DNAdam↑, Dose?,

604-

ZO,

Plant-Mediated Zinc Oxide Nanoparticles: Advances in the New Millennium towards Understanding Their Therapeutic Role in Biomedical Applications

-

Review,

NA,

NA

ROS↑, Apoptosis↑, DNAdam↑,

Showing Research Papers: 301 to 312 of 312
Prev Page 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 312

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

H2O2↑, 2, HO-1↑, 1, NRF2↑, 1, ROS↑, 9,

Mitochondria & Bioenergetics ⓘ

ATP↓, 1, MMP↓, 2,

Core Metabolism/Glycolysis ⓘ

NAD↓, 2, Warburg↓, 1,

Cell Death ⓘ

Apoptosis↑, 3, Casp3↑, 1, cl‑Casp3↑, 1, proCasp3↑, 1, pro‑Casp3↑, 1, cl‑Casp9↑, 1, Cyt‑c↑, 1, Fas↑, 1, FasL↑, 1, necrosis↑, 1, TumCD↑, 2,

Transcription & Epigenetics ⓘ

cJun↑, 1, other↑, 1,

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

DNAdam↑, 9, P53↑, 1, PARP↑, 1,

Cell Cycle & Senescence ⓘ

P21↑, 1, TumCCA↑, 1,

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

TET1↑, 1, TumMeta↓, 1,

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Drug Metabolism & Resistance ⓘ

BioAv↑, 2, ChemoSen↑, 1, Dose?, 2, eff↑, 3, RadioS↑, 1, selectivity↑, 3,

Functional Outcomes ⓘ

AntiCan↑, 2, Risk↓, 1, toxicity∅, 1, TumVol↓, 1,
Total Targets: 43

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 1, HO-1↑, 1, Keap1↓, 1, NRF2↑, 1, ROS↓, 3,

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

iNOS↓, 1, p38↓, 1,

DNA Damage & Repair ⓘ

Migration ⓘ

TGF-β↓, 1, TIMP1↓, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 1, IL6↓, 1, Inflam↓, 1, TNF-α↓, 2,

Clinical Biomarkers ⓘ

ALAT↓, 1, Albumin↑, 1, AST↓, 1, IL6↓, 1,
Total Targets: 19

Scientific Paper Hit Count for: DNAdam, DNA damage

30 Silver-NanoParticles
16 Radiotherapy/Radiation
16 Vitamin C (Ascorbic Acid)
12 Magnetic Fields
11 Curcumin
9 Fisetin
7 Ashwagandha(Withaferin A)
7 Chrysin
7 Lycopene
7 salinomycin
7 Selenium NanoParticles
6 Artemisinin
6 Chemotherapy
6 Cisplatin
6 Apigenin (mainly Parsley)
6 Berberine
6 Carvacrol
6 Piperlongumine
6 Quercetin
6 Sulforaphane (mainly Broccoli)
5 Copper and Cu NanoParticles
5 Allicin (mainly Garlic)
5 Baicalein
5 Betulinic acid
5 Ellagic acid
5 diet FMD Fasting Mimicking Diet
5 nicotinamide adenine dinucleotide
5 Selenite (Sodium)
5 Thymoquinone
4 Auranofin
4 Capsaicin
4 Thymol-Thymus vulgaris
4 Emodin
4 Electrical Pulses
4 Vitamin B3,Niacin
4 Propolis -bee glue
4 Resveratrol
4 Shikonin
3 doxorubicin
3 borneol
3 Boron
3 Boswellia (frankincense)
3 Rosmarinic acid
3 Cat’s Claw
3 Magnolol
3 Magnetic Field Rotating
3 Phenethyl isothiocyanate
3 Selenium
3 Silymarin (Milk Thistle) silibinin
3 Vitamin K2
2 chitosan
2 Moringa oleifera
2 Metformin
2 Melatonin
2 Astaxanthin
2 Aloe anthraquinones
2 brusatol
2 Bruteridin(bergamot juice)
2 Caffeic acid
2 Carnosic acid
2 diet Short Term Fasting
2 Disulfiram
2 EGCG (Epigallocatechin Gallate)
2 Gallic acid
2 Garcinol
2 γ-linolenic acid (Borage Oil)
2 Hydroxycinnamic-acid
2 Juglone
2 Propyl gallate
2 Ursolic acid
2 VitK3,menadione
1 3-bromopyruvate
1 5-Hydroxytryptophan
1 Astragalus
1 Gold NanoParticles
1 Photodynamic Therapy
1 entinostat
1 tamoxifen
1 Alpha-Lipoic-Acid
1 Ascorbyl Palmitate
1 Baicalin
1 Biochanin A
1 Gemcitabine (Gemzar)
1 Bromelain
1 Black phosphorus
1 Zinc
1 carboplatin
1 Catechins
1 Chlorogenic acid
1 Chlorophyllin
1 Cinnamon
1 Coenzyme Q10
1 Calorie Restriction Mimetics
1 chemodynamic therapy
1 Deguelin
1 immunotherapy
1 Butyrate
1 Ferulic acid
1 Galloflavin
1 Gambogic Acid
1 Honokiol
1 HydroxyTyrosol
1 Licorice
1 Luteolin
1 Nimbolide
1 Piperine
1 Plumbagin
1 Sulfasalazine
1 Aflavin-3,3′-digallate
1 temozolomide
1 Urolithin
1 Iron
1 Magnesium
1 Zinc Oxide

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:82  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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