Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
2401- Flav,    In vitro effects of some flavonoids and phenolic acids on human pyruvate kinase isoenzyme M2
- in-vitro, Nor, NA
PKM2↓,
2313- Flav,    Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism
- Review, Var, NA
Warburg↓, antiOx↑, angioG↓, Glycolysis↓, PKM2↓, PKM2:PKM1↓, β-catenin/ZEB1↓, cMyc↓, HK2↓, Akt↓, mTOR↓, GLUT1↓, Hif1a↓,
2642- Flav,  QC,  Api,  KaempF,  MCT  In Vitro–In Vivo Study of the Impact of Excipient Emulsions on the Bioavailability and Antioxidant Activity of Flavonoids: Influence of the Carrier Oil Type
- in-vitro, Nor, NA - in-vivo, Nor, NA
*BioAv↑, *eff↝, BioEnh↑,
4250- Flav,    Dietary Flavonoids Interaction with CREB-BDNF Pathway: An 
Unconventional Approach for Comprehensive Management of Epilepsy
- Review, NA, NA
*ERK↑, *BDNF↑, *CREB↑,
4063- Flav,  VitB12,  VitB6,    Homocysteine and Dementia: An International Consensus Statement
- Review, AD, NA
*homoC↓, *cognitive↑,
4060- Flav,    Vitamin Supplementation and Dementia: A Systematic Review
- Review, AD, NA
*cognitive↑,
4107- FLS,  Ex,    Combined effects of aerobic exercise and 40-Hz light flicker exposure on early cognitive impairments in Alzheimer's disease of 3×Tg mice
- in-vivo, AD, NA
*Aβ↓, *cognitive↑, *Inflam↓, *eff↑,
4108- FLS,    Improvement of olfactory function in AD mice mediated by immune responses under 40 Hz light flickering
- in-vivo, AD, NA
*other↑,
4121- FLS,    Sensory-Evoked 40-Hz Gamma Oscillation Improves Sleep and Daily Living Activities in Alzheimer’s Disease Patients
- Trial, AD, NA
*cognitive↑, *Sleep↑,
4023- FulvicA,    Shilajit (Mumio) Elicits Apoptosis and Suppresses Cell Migration in Oral Cancer Cells through Targeting Urokinase-type Plasminogen Activator and Its Receptor and Chemokine Signaling Pathways
- in-vitro, Oral, NA
tumCV↓, selectivity↑, Apoptosis↑, uPA↓, TumCMig↓, Dose↝, CXCc↓,
4022- FulvicA,  Chemo,    Shilajit potentiates the effect of chemotherapeutic drugs and mitigates metastasis induced liver and kidney damages in osteosarcoma rats
- in-vivo, OS, NA
AST↓, ALAT↓, ALP↓, Bil↝, creat↓, uricA↓, ChemoSen↑, chemoP↑,
4024- FulvicA,    ANTI-CARCINOGENIC ACTIVITY OF SHILAJIT REGARDING TO APOPTOSIS ASSAY IN CANCER CELLS: A SYSTEMATIC REVIEW OF IN-VITRO STUDIES
- Review, Var, NA
*Inflam↓, *antiOx↑, TumCG↓, tumCV↓, ROS↑, ChemoSen↑, toxicity↝,
4025- FulvicA,    Mumio (Shilajit) as a potential chemotherapeutic for the urinary bladder cancer treatment
- in-vitro, Bladder, T24/HTB-9 - Review, AD, NA
tumCV↓, selectivity↑, TumCCA↑, other↝, *neuroP↑, *memory↑, *tau↓, *other↝, *lipid-P↓, *VitC↑, *antiOx↑,
4026- FulvicA,    Shilajitin Cancer Treatment: Probable Mode of Action
- Review, Var, NA
*Inflam↓, *antiOx↑, Dose↝,
4027- FulvicA,    Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
tumCV↓, selectivity↑, TGF-β↓, Twist↓, NOTCH1↓, CTNNB1↓, Src↓, E-cadherin↑, EMT↓, TumMeta↓, BioAv↑,
4028- FulvicA,    Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells
- in-vitro, Liver, HUH7
Apoptosis↑, TumCP↓, ROS↑, NO↑, Dose↝, MMP↓, Cyt‑c↑, SOD↓, Catalase↓, GSH↑, lipid-P↑, miR-21↓, miR-22↑,
4029- FulvicA,  Chemo,    Shilajit mitigates chemotherapeutic drug-induced testicular toxicity: Study on testicular germ cell dynamics, steroidogenesis modulation, and Nrf-2/Keap-1 signaling
- in-vivo, Var, NA
*other↑, *PCNA↑, *SOD↑, *lipid-P↓, *NRF2↑, *Keap1↓, *chemoP↑,
4030- FulvicA,    Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes
- Review, NA, NA
*Inflam↓, TNF-α↓, *COX2↓, *PGE2↓, *ROS↓, *GutMicro↑, *BioEnh↑, *BioEnh↑, *SOD↑, *Catalase↑, *GPx↑,
4018- FulvicA,  Fe,    Inhibitory Impacts of Fulvic Acid-Coated Iron Oxide Nanoparticles on the Amyloid Fibril Aggregations
- in-vivo, AD, NA
*Inflam↓, *Aβ↓,
4017- FulvicA,    Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease
- NA, AD, NA
*cognitive↑, *tau↓,
4019- FulvicA,    Can nutraceuticals prevent Alzheimer's disease? Potential therapeutic role of a formulation containing shilajit and complex B vitamins
- Review, AD, NA
*neuroP↑,
4016- FulvicA,    Shilajit: A Natural Phytocomplex with Potential Procognitive Activity
- Review, AD, NA
*tau↓, *AntiAge↑, *Strength↑, *Dose↝, *BioAv↑, *antiOx↑, *memory↑, *Inflam↓, *cognitive↑, *neuroP↑, *toxicity↝, *toxicity↑,
4020- FulvicA,    Natural products as a rich source of tau-targeting drugs for Alzheimer’s disease
- in-vitro, AD, NA
*tau↓, *cognitive↑,
4021- FulvicA,    Scaling the Andean Shilajit: A Novel Neuroprotective Agent for Alzheimer’s Disease
- in-vitro, AD, NA
*tau↓, *neuroP↑,
987- GA,    Targeting Aerobic Glycolysis: Gallic Acid as Promising Anticancer Drug
- in-vitro, GBM, AMGM - in-vitro, Cerv, HeLa - in-vitro, BC, MCF-7
LDH↓, TumCG↓,
997- GA,    The Inhibitory Mechanisms of Tumor PD-L1 Expression by Natural Bioactive Gallic Acid in Non-Small-Cell Lung Cancer (NSCLC) Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H292 - in-vitro, Nor, HUVECs
PD-L1↓, p‑EGFR↓, p‑PI3K↓, p‑Akt↓, P53↑, miR-34a↑, *toxicity↓,
947- GA,    Gallic acid, a phenolic compound, exerts anti-angiogenic effects via the PTEN/AKT/HIF-1α/VEGF signaling pathway in ovarian cancer cells
- in-vitro, Ovarian, OVCAR-3 - in-vitro, Melanoma, A2780S - in-vitro, Nor, IOSE364 - Human, NA, NA
TumCG↓, VEGF↓, angioG↓, p‑Akt↓, Hif1a↓, PTEN↑, BioAv↑, *toxicity↓,
1091- GA,    Gallic acid reduces cell viability, proliferation, invasion and angiogenesis in human cervical cancer cells
- in-vitro, Cerv, HeLa - in-vitro, Cerv, HTB-35
tumCV↓, TumCP↓, ADAM17↓, EGFR↓, p‑Akt↓, p‑ERK↓,
1115- GA,    Gallic acid alleviates gastric precancerous lesions through inhibition of epithelial mesenchymal transition via Wnt/β-catenin signaling pathway
- in-vivo, GC, GES-1
TumCP↓, TumCCA↑, Wnt/(β-catenin)↓, EMT↓,
1086- GA,    Anti-leukemic effects of gallic acid on human leukemia K562 cells: downregulation of COX-2, inhibition of BCR/ABL kinase and NF-κB inactivation
- in-vitro, AML, K562
tumCV↓, TumCCA↑, P21↑, p27↑, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Cyt‑c↑, cl‑PARP↓, DNAdam↑, Casp3↑, FASN↓, Casp8↑,
1065- GA,    Gallic acid, a phenolic acid, hinders the progression of prostate cancer by inhibition of histone deacetylase 1 and 2 expression
- vitro+vivo, Pca, NA
tumCV↓, MMP↓, DNAdam↑, HDAC1↓, HDAC2↓, PCNA↓, cycD1/CCND1↓, cycE1↓, P21↑, TumVol↓,
1283- GA,  immuno,    Gallic acid induces T-helper-1-like Treg cells and strengthens immune checkpoint blockade efficacy
- vitro+vivo, CRC, NA
p‑STAT3↓, Treg lymp↓, FOXP3↓, CD8+↑, IFN-γ↑,
1300- GA,  PacT,  carbop,    Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line
- in-vitro, BC, MCF-7
TumCCA↑, Apoptosis↑, P53↑, BAX↑, Casp3↑, Bcl-2↓,
1773- GA,    Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action
- Review, Var, NA
antiOx↑, AntiCan↑, Inflam↑, GutMicro↑, BioAv↝, BioAv↓, BioAv↑, TumMeta↓,
1624- GA,    Anticancer Effect of Pomegranate Peel Polyphenols against Cervical Cancer
- in-vitro, Cerv, NA
ROS↑, Dose∅, MMP↓, GSH↑,
3719- GABA,    Treatment Options in Alzheimer´s Disease: The GABA Story
- Review, AD, NA
*other↓,
3720- GABA,    Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review
- Review, AD, NA
*Sleep∅,
4248- Gala,    Meta-analysis of randomized controlled trials of galantamine in schizophrenia: significant cognitive enhancement
- Review, NA, NA
*BDNF↑, *cognitive↑,
935- Gallo,    Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
LDH↓, ROS↑, TumCP↓, Glycolysis↓, ATP↓, ER-α36↓, Apoptosis?,
934- Gallo,    Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase
- Analysis, NA, NA
LDH↓, Glycolysis↓, Apoptosis↑,
5207- Gallo,    Targeting pancreatic cancer with combinatorial treatment of CPI-613 and inhibitors of lactate metabolism
LDH↓, TumCP↓, TumCG∅,
5206- Gallo,    Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells
- in-vitro, Var, NA
LDHA↓, Glycolysis↓, TumCP↓,
5205- Gallo,    Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells
- in-vitro, Endo, ISH
LDH↓, TumCG↓, LDHA↓, Apoptosis↑, cl‑Casp3↑, Mcl-1↓, Bcl-2↓, TumCCA↑, ROS↑, mt-DNAdam↑, GlucoseCon↓, ATP↓, PDH↑, Pyruv↑, Glycolysis↓, TCA↑, cMyc↓, E-cadherin↑, Slug↓,
1954- GamB,    Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase
- in-vitro, HCC, SMMC-7721 cell
AntiTum↑, TrxR↓, TrxR1↓, ROS↑, Apoptosis↑, Dose∅, Dose?,
1955- GamB,    Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
ROS↑, Apoptosis↑, Ferroptosis↑, Trx↓, eff↑, TrxR↓, Dose∅, MMP↓, eff↑, Casp↑, NADPH↓, TrxR↓, ChemoSen↑, AR↓,
1956- GamB,    Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis
- in-vitro, Melanoma, A375
tumCV↓, Apoptosis↑, ROS↑, p66Shc↑,
1957- GamB,    Nanoscale Features of Gambogic Acid Induced ROS-Dependent Apoptosis in Esophageal Cancer Cells Imaged by Atomic Force Microscopy
- in-vitro, ESCC, EC9706
AntiCan↑, toxicity↓, TumCP↓, Apoptosis↑, TumCCA↑, MMP↓, ROS↑, eff↓, RadioS↑,
1958- GamB,    Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells
- in-vitro, Pca, NA - in-vivo, NA, NA
AntiCan↑, TumCP↓, TumAuto↑, eff↑, JNK↑, ROS↑, ER Stress↑, eff↓, TumCG↓,
1959- GamB,    Gambogic acid induces GSDME dependent pyroptotic signaling pathway via ROS/P53/Mitochondria/Caspase-3 in ovarian cancer cells
- in-vitro, Ovarian, NA - in-vivo, NA, NA
AntiCan↑, Pyro↑, tumCV?, CellMemb↓, cl‑Casp3↑, GSDME-N↑, ROS?, p‑P53↑, eff↓, MMP↓, Bcl-2↓, BAX↑, mtDam↑, Cyt‑c↑, TumCG↓, CD4+↑, CD8+↑,
1960- GamB,  Vem,    Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation
- in-vitro, Liver, HepG2 - in-vitro, AML, K562
Proteasome↓, eff↑, Casp↑, ER Stress↑, ROS↑, eff↑,

Showing Research Papers: 3451 to 3500 of 6624
Prev Page 70 of 133 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6624

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Bil↝, 1,   Catalase↓, 1,   Ferroptosis↑, 1,   GSH↑, 2,   lipid-P↑, 1,   p66Shc↑, 1,   ROS?, 1,   ROS↑, 11,   SOD↓, 1,   Trx↓, 1,   TrxR↓, 3,   TrxR1↓, 1,   uricA↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   MMP↓, 6,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   cMyc↓, 2,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 5,   HK2↓, 1,   LDH↓, 5,   LDHA↓, 2,   NADPH↓, 1,   PDH↑, 1,   PKM2↓, 2,   PKM2:PKM1↓, 1,   Pyruv↑, 1,   TCA↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 3,   Apoptosis?, 1,   Apoptosis↑, 9,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Casp↑, 2,   Casp3↑, 2,   cl‑Casp3↑, 2,   Casp8↑, 1,   Cyt‑c↑, 3,   Ferroptosis↑, 1,   GSDME-N↑, 1,   JNK↑, 1,   Mcl-1↓, 1,   p27↑, 1,   Proteasome↓, 1,   Pyro↑, 1,  

Transcription & Epigenetics ⓘ

miR-21↓, 1,   other↝, 1,   tumCV?, 1,   tumCV↓, 8,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 2,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   mt-DNAdam↑, 1,   P53↑, 2,   p‑P53↑, 1,   cl‑PARP↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   cycE1↓, 1,   P21↑, 2,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State ⓘ

CTNNB1↓, 1,   EMT↓, 2,   p‑ERK↓, 1,   HDAC1↓, 1,   HDAC2↓, 1,   miR-34a↑, 1,   mTOR↓, 1,   NOTCH1↓, 1,   p‑PI3K↓, 1,   PTEN↑, 1,   Src↓, 1,   p‑STAT3↓, 1,   TumCG↓, 6,   TumCG∅, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

E-cadherin↑, 2,   ER-α36↓, 1,   miR-22↑, 1,   Slug↓, 1,   TGF-β↓, 1,   Treg lymp↓, 1,   TumCMig↓, 1,   TumCP↓, 8,   TumMeta↓, 2,   Twist↓, 1,   uPA↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   EGFR↓, 1,   p‑EGFR↓, 1,   Hif1a↓, 2,   NO↑, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

CellMemb↓, 1,   GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   CXCc↓, 1,   FOXP3↓, 1,   IFN-γ↑, 1,   Inflam↑, 1,   PD-L1↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment ⓘ

ADAM17↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 3,   Dose?, 1,   Dose↝, 3,   Dose∅, 3,   eff↓, 3,   eff↑, 5,   RadioS↑, 1,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AR↓, 1,   AST↓, 1,   Bil↝, 1,   creat↓, 1,   EGFR↓, 1,   p‑EGFR↓, 1,   GutMicro↑, 1,   LDH↓, 5,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 4,   AntiTum↑, 1,   chemoP↑, 1,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 2,  
Total Targets: 142

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 4,   Catalase↑, 1,   GPx↑, 1,   Keap1↓, 1,   lipid-P↓, 2,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 2,   VitC↑, 1,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 1,   homoC↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 2,   other↝, 1,  

DNA Damage & Repair ⓘ

PCNA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 6,   PGE2↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 2,   tau↓, 5,  

Protein Aggregation ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   BioEnh↑, 2,   Dose↝, 1,   eff↑, 1,   eff↝, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   chemoP↑, 1,   cognitive↑, 8,   memory↑, 2,   neuroP↑, 4,   Sleep↑, 1,   Sleep∅, 1,   Strength↑, 1,   toxicity↓, 2,   toxicity↑, 1,   toxicity↝, 1,  
Total Targets: 39

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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