Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
796- GAR,    Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression
- vitro+vivo, Pca, HeLa
HATs↓, PCAF↓, Apoptosis↑,
832- GAR,  Rad,    Garcinol, a Histone Acetyltransferase Inhibitor, Radiosensitizes Cancer Cells by Inhibiting Non-Homologous End Joining
- in-vitro, Lung, A549 - in-vitro, NA, HeLa
HATs↓, other↑,
831- GAR,  CUR,    Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells
- in-vitro, AML, HL-60
Apoptosis↑, Casp3↑, MMP↓, Cyt‑c↑, proCasp9↑, Bcl-2↓, BAX↑, PARP↓, DNAdam↑, DFF45↓,
830- GAR,    Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells
- in-vitro, CRC, HT-29
TumCI↓, TumCMig↓, Apoptosis↑, p‑FAK↓, Src↓, MAPK↓, ERK↓, PI3K/Akt↓, Bax:Bcl2↑, Cyt‑c↑, MMP7↓,
829- GAR,    The Role of T-Cadherin (CDH13) in Treatment Options with Garcinol in Melanoma
- vitro+vivo, Melanoma, NA

828- GAR,  Cisplatin,    Garcinol Alone and in Combination With Cisplatin Affect Cellular Behavior and PI3K/AKT Protein Phosphorylation in Human Ovarian Cancer Cells
- in-vitro, Ovarian, OVCAR-3
tumCV↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, p‑PI3K↓, p‑Akt↓, NF-kB↓,
827- GAR,    Garcinol Is an HDAC11 Inhibitor
- in-vitro, NA, NA
HDAC11↓,
826- GAR,    Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
- vitro+vivo, HCC, HepG2 - vitro+vivo, Liver, HUH7
STAT3↓, TumCP↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCCA↑, TumVol↓,
793- GAR,    Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer
- in-vitro, SCC, SCC9 - in-vitro, SCC, SCC4 - in-vitro, SCC, SCC25
TumCG↓, Apoptosis↑, TumCCA↑, NF-kB↓, COX2↓, VEGF↓,
794- GAR,    Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression
- in-vitro, RCC, NA - in-vitro, Lung, A549 - in-vitro, Nor, NA
DR5↑, cFLIP↓, *toxicity↓,
795- GAR,    Garcinol—A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug
- Review, NA, NA
HATs↓, BAX↑, PARP↑, Bcl-2↓, Casp3↑, Casp9↑, DR5↑, cFLIP↓, MMP2↓, MMP9↓, STAT3↓, p‑Akt↓,
797- GAR,  CUR,    Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells
- in-vitro, BC, MCF-7 - in-vitro, OS, U2OS - in-vitro, OS, SaOS2
TumCP↓, H3K18↓, DNAdam↑,
1117- Gb,    Ginkgobiloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3/TGF-β1 and Smad3/p38 MAPK pathways
- vitro+vivo, Kidney, HK-2
α-SMA↓, COL1↓, TGF-β↓, SMAD2↓, SMAD3↓, p‑SMAD2↓, p‑SMAD3↓, p38↓, p‑p38↓, Vim↓, TIMP1↓, CTGF↓, E-cadherin↑, MMP1:TIMP1↑,
1190- Gb,    Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model
- in-vivo, CRC, SW-620
TumMeta↑, Ki-67↑,
1189- Gb,    New insight into the mechanisms of Ginkgo biloba leaves in the treatment of cancer
- Review, NA, NA
Apoptosis↑, TumCP↓, TumCI↓, TumCMig↓, Inflam↓, antiOx↑, angioG↓,
1188- Gb,    The potential of Ginkgo biloba in the treatment of human diseases and the relationship to Nrf2-mediated antioxidant protection
- Review, NA, NA
*NRF2↑, *ROS↓,
1187- Gb,    Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase
- in-vitro, Melanoma, U251 - in-vitro, Melanoma, MM.1S
STAT3↓, PTEN↑, Apoptosis↑, PTPN6↑,
1186- Gb,    Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis
- in-vitro, PC, NA - in-vitro, Nor, HUVECs - in-vivo, PC, NA
tumCV↓, *toxicity∅, TumCMig↓, TumCI↓, Apoptosis↑, AMPK↑, lipoGen↓, ACC↓, FASN↓,
4245- Gb,    Standardized extract of Ginkgo biloba enhances memory persistence over time
- in-vivo, NA, NA
*memory↑, *BDNF↑,
4244- Gb,    Effects of Six-Week Ginkgo biloba Supplementation on Aerobic Performance, Blood Pro/Antioxidant Balance, and Serum Brain-Derived Neurotrophic Factor in Physically Active Men
- Human, Nor, NA
*BDNF∅,
3722- Gb,    Alzheimer's disease: Research summaries – Do Ginkgo products help?
- Review, AD, NA
*memory↑, *AntiAg↑,
3723- Gb,    Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies
- Review, AD, NA
*memory↑, *antiOx↑, *Casp3↓, *APP↓, *AChE↓, *Aβ↓, *5HT↑, *SOD↓, *MDA↓, *NO↓, *GSH↑, *Bcl-2↑, *BAX↑, *TNF-α↓, *IL1β↑, *iNOS↓, *IL10↓, *p‑tau↓, *ROS↓, *MAOB↓, *cognitive↑, *neuroP↑, *Apoptosis↓,
3721- Gb,    Ginkgo biloba Extract in Alzheimer’s Disease: From Action Mechanisms to Medical Practice
- Review, AD, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSR↑, *MMP↑, *Inflam↓, *Aβ↓, *memory↑, *Dose↝, *BBB↑, *neuroP↑,
790- GE,    A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium)
- vitro+vivo, NA, NA
other↓,
791- GE,    Germanium Sesquioxide Organic Germanium
other↝,
792- GE,    The role of germanium in diseases: exploring its important biological effects
other↓,
789- GE,    Complete remission of pulmonary spindle cell carcinoma after treatment with oral germanium sesquioxide
- Case Report, SCC, NA
Remission↑,
28- GEN,    Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway
- in-vivo, BC, MCF-7
HH↓, Smo↓, Gli1↓, TumCG↓, TumCP↓, Apoptosis↑, CSCs↓,
29- GEN,    Genistein inhibits the stemness properties of prostate cancer cells through targeting Hedgehog-Gli1 pathway
- in-vivo, Pca, 22Rv1 - in-vivo, Pca, DU145
HH↓, Gli1↓, CSCs↓, TumCI↓, EMT↓, TumCG↓, CD44↓,
166- GEN,  EGCG,  RES,  CUR,    Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer
- in-vivo, Pca, NA
HH↓, Gli1↓,
927- GEN,  PacT,    Bioenhancers from mother nature and their applicability in modern medicine
- Review, Nor, NA
*BioAv↑,
2998- GEN,    Cellular and Molecular Mechanisms Modulated by Genistein in Cancer
- Review, Var, NA
Hif1a↓, VEGF↓, PDGF↓, uPA↓, MMP2↓, MMP9↓, chemoPv↑, TumCI↓, TumMeta↓, NF-kB↓, AP-1↓, IKKα↓, PI3K↓, Akt↓, EMT↓, CSCs↓,
2997- GEN,    Genistein Inhibition of Topoisomerase IIα Expression Participated by Sp1 and Sp3 in HeLa Cell
- in-vitro, Cerv, HeLa
TOP2↓, Sp1/3/4↓, Apoptosis↑, TumCCA↑,
4664- GEN,  CUR,  RES,  EGCG,  SFN  Targeting cancer stem cells by nutraceuticals for cancer therapy
- Review, Var, NA
CSCs↓, other↝, eff↑, CD44↓, p‑STAT3↓,
1504- GEN,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
DNMTs↓, P21↑, p16↑, ac‑H3↑, ac‑H4↑, TumCCA↑, Casp↑, Apoptosis↑, hTERT/TERT↓, BTG3↑,
1435- GEN,  SFN,    The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
DNMTs↓, HDAC↓, eff↑, TumCCA↑, HMTs↓, HDAC2↓, HDAC3↓, KLF4↓, hTERT/TERT↓,
30- Ger,    A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, AsPC-1
HH↓, Gli1↓, Shh↓, cycD1/CCND1↓, TumCP↓,
6571- Ger,    Unlocking the therapeutic potential of Geraniol: an alternative perspective for metabolic disease management
- Review, Obesity, NA
*lipidLev↓, *antiOx↓, Inflam↓, *ROS↓, *BioAv↑, *AntiDiabetic↑, *Obesity↓,
6561- Ger,    Geraniol Pharmacokinetics, Bioavailability and Its Multiple Effects on the Liver Antioxidant and Xenobiotic-Metabolizing Enzymes
- in-vivo, Nor, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiCan↑, *BioAv↝, *Dose↝, *toxicity↓, *Catalase↑, *NADPH↑, *GSR↑, *ALAT∅, *AST∅,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1↓,
6563- Ger,  5-FU,    Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts
- vitro+vivo, Colon, SW-620 - in-vitro, Colon, Caco-2
TS↓, TK1↓, ChemoSen↑, TumVol↓, OS↑,
6564- Ger,    Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2
- in-vitro, HCC, HepG2
TumCG↓, HMG-CoA↓, TumCP↓, eff↑, Dose↝,
6565- Ger,    Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrest
- in-vitro, CRC, COLO205
AntiCan↑, mt-Apoptosis↑, BAX↑, Bcl-2↓, DNAdam↑, TumCCA↑,
6566- Ger,  5-FU,    Geraniol, a Component of Plant Essential Oils, Sensitizes Human Colonic Cancer Cells to 5-Fluorouracil Treatment
- in-vitro, CRC, NA
TumCP↓, ChemoSen↑, other↝, EPR↑,
6567- Ger,    Geraniin inhibits proliferation and induces apoptosis through inhibition of phosphatidylinositol 3-kinase/Akt pathway in human colorectal cancer in vitro and in vivo
- vitro+vivo, CRC, SW480 - in-vitro, CRC, HT29
AntiTum↑, *Inflam↓, *antiOx↓, TumCP↓, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑PI3K↓, p‑Akt↓, Dose↝, TumCG↓,
6568- Ger,    Perturbation by geraniol of cell membrane permeability and signal transduction pathways in human colon cancer cells
- in-vitro, Colon, Caco-2
HMG-CoA↓, MMP↓, PKCδ↓, ERK↓,
6569- Ger,    Geraniol inhibits cell growth and promotes caspase-dependent apoptosis in nasopharyngeal cancer C666-1 cells via inhibiting PI3K/Akt/mTOR signaling pathway
- in-vitro, NPC, C666-1
tumCV↓, MMP↓, Apoptosis↑, TBARS↑, GSH↓, SOD↓, BAX↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, mTOR↓, DNAdam↑, ROS↑,
6570- Ger,    Apoptosis-Mediated Anticancer Activity of Geraniol Inhibits NF-κB, MAPK, and JAK-STAT-3 Signaling Pathways in Human Thyroid Cancer Cells
- in-vitro, Thyroid, TPC-1
*Inflam↓, AntiCan↑, *neuroP↑, tumCV↓, TumCP↓, ROS↑, Apoptosis?, MMP↓, Bcl-2↓, cycD1/CCND1↓, cMyc↓, COX2↓, TNF-α↓, NF-kB↓, IL6↓, survivin↓, BAX↑, Casp3↑, JAK2↓, STAT3↓, ERK↓,
6572- Ger,    Pharmacokinetics of Geraniol and Its Metabolites in Mice After Oral Administration
- in-vivo, Nor, NA
BioAv↝, BBB↑, BioAv↝, Half-Life↝,
6573- Ger,    Systematic elucidation of the mechanism of geraniol via network pharmacology
- Study, Nor, NA - Study, Var, NA
HO-1↝, HRAS↓, *IL8↓, *AChE↓, NF-kB↓, PCNA↓, BAX↑, Bcl-2↓, P53↑, Casp3↑, Casp8↑, Casp9↑,

Showing Research Papers: 3551 to 3600 of 6624
Prev Page 72 of 133 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6624

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

TK1↓, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↓, 1,   HO-1↝, 1,   ROS↓, 1,   ROS↑, 2,   SOD↓, 1,   TBARS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 4,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   AMPK↑, 1,   cMyc↓, 1,   FASN↓, 1,   HMG-CoA↓, 2,   lipoGen↓, 1,   PI3K/Akt↓, 1,   TS↓, 1,  

Cell Death ⓘ

Akt↓, 2,   p‑Akt↓, 3,   Apoptosis?, 1,   Apoptosis↑, 12,   mt-Apoptosis↑, 1,   BAX↑, 8,   Bax:Bcl2↑, 1,   Bcl-2↓, 7,   Bcl-xL↓, 1,   BTG3↑, 1,   Casp↑, 1,   Casp↝, 1,   Casp3↑, 6,   cl‑Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 4,   proCasp9↑, 1,   cFLIP↓, 2,   Cyt‑c↑, 2,   DR5↑, 2,   hTERT/TERT↓, 2,   MAPK↓, 1,   Mcl-1↓, 1,   p38↓, 1,   p‑p38↓, 1,   survivin↓, 2,  

Kinase & Signal Transduction ⓘ

H3K18↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 3,   other↓, 2,   other↑, 1,   other↝, 3,   PCAF↓, 1,   tumCV↓, 4,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,  

DNA Damage & Repair ⓘ

DFF45↓, 1,   DNAdam↑, 4,   DNMTs↓, 2,   p16↑, 1,   P53↑, 1,   P53↝, 1,   PARP↓, 1,   PARP↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 3,   P21↑, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 2,   CSCs↓, 4,   EMT↓, 2,   ERK↓, 3,   Gli1↓, 4,   HDAC↓, 1,   HDAC11↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HH↓, 4,   HMTs↓, 1,   HRAS↓, 1,   KLF4↓, 1,   mTOR↓, 1,   PI3K↓, 2,   p‑PI3K↓, 2,   PTEN↑, 1,   PTPN6↑, 1,   Shh↓, 1,   Smo↓, 1,   Src↓, 1,   STAT3↓, 5,   p‑STAT3↓, 1,   TOP2↓, 1,   TumCG↓, 5,   TumCG↑, 1,  

Migration ⓘ

AP-1↓, 1,   COL1↓, 1,   CTGF↓, 1,   E-cadherin↑, 1,   p‑FAK↓, 1,   Ki-67↑, 1,   MMP1:TIMP1↑, 1,   MMP2↓, 3,   MMP7↓, 1,   MMP9↓, 3,   PDGF↓, 1,   PKCδ↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   TGF-β↓, 1,   TIMP1↓, 1,   TumCI↓, 6,   TumCMig↓, 5,   TumCP↓, 10,   TumMeta↓, 2,   TumMeta↑, 1,   uPA↓, 1,   Vim↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   EPR↑, 1,   Hif1a↓, 2,   VEGF↓, 3,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IKKα↓, 1,   IL6↓, 1,   Inflam↓, 2,   JAK2↓, 1,   NF-kB↓, 5,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 2,   ChemoSen↑, 2,   Dose↝, 2,   eff↑, 3,   Half-Life↝, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

hTERT/TERT↓, 2,   IL6↓, 1,   Ki-67↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   chemoPv↑, 1,   OS↑, 1,   Remission↑, 1,   TumVol↓, 2,  
Total Targets: 146

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↓, 2,   antiOx↑, 4,   Catalase↑, 3,   GPx↑, 1,   GSH↑, 2,   GSR↑, 2,   GSTs↑, 1,   HO-1↑, 1,   MDA↓, 1,   NRF2↑, 2,   ROS↓, 4,   SOD↓, 1,   SOD↑, 2,   TBARS↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT∅, 1,   lipidLev↓, 1,   NADPH↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   BAX↑, 1,   Bcl-2↑, 1,   Casp3↓, 1,   iNOS↓, 2,   survivin↓, 1,  

Migration ⓘ

AntiAg↑, 1,   APP↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 2,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL1β↑, 1,   IL8↓, 1,   Inflam↓, 5,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 3,   BDNF↑, 1,   BDNF∅, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,   MAOB↓, 1,   XO↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   BioAv↝, 1,   Dose↝, 2,  

Clinical Biomarkers ⓘ

ALAT∅, 1,   AST∅, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 1,   cognitive↑, 1,   memory↑, 5,   neuroP↑, 5,   Obesity↓, 1,   toxicity↓, 2,   toxicity∅, 1,  
Total Targets: 58

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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