Cancer Database Query Results

Scientific Papers found: Click to Expand⟱

Gra,

Cytotoxic Effect of Annona muricata leaf extracts on tumor cell lines in vitro

in-vitro,

BC,

MDA-MB-231

134.6 mg/ml

in-vitro,

Lung,

A549

124.6 mg/ml

Apoptosis↑,

847-

Gra,

Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I).

NADHdeh↓,

858-

Gra,

Annona muricata leaves induce G₁ cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells

in-vitro,

CRC,

HT-29

11.43 µg/ml

in-vitro,

CRC,

HCT116

8.98 µg/ml

TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Casp↑, BAX↑, Bcl-2↓, TumCMig↓, TumCI↓,

857-

Gra,

The Value of Caspase-3 after the Application of Annona muricata Leaf Extract in COLO-205 Colorectal Cancer Cell Line

in-vitro,

CRC,

COLO205

Casp3↑, tumCV↓,

856-

Gra,

https://pubmed.ncbi.nlm.nih.gov/33048613/

in-vitro,

BC,

MCF-7

85.55 µg/mL

TumCCA↑, ROS↑, Casp↑,

855-

Gra,

Antiproliferative activity of ionic liquid-graviola fruit extract against human breast cancer (MCF-7) cell lines using flow cytometry techniques

in-vitro,

BC,

MCF-7

 4.75 μg/mL

TumCG↓, TumCP↓, TumCCA↑, Apoptosis↑,

854-

Gra,

AgNPs,

Green Synthesis of Silver Nanoparticles Using Annona muricata Extract as an Inducer of Apoptosis in Cancer Cells and Inhibitor for NLRP3 Inflammasome via Enhanced Autophagy

vitro+vivo,

AML,

THP1

17.34 µg/mL

in-vitro,

AML,

AMJ13

vitro+vivo,

lymphoma,

HBL

TumCP↓, TumAuto↑, IL1↓, NLRP3↓, Apoptosis↑, mtDam↑, P53↑, LDH↓,

853-

Gra,

AgNPs,

Solid lipid nanoparticles of Annona muricata fruit extract: formulation, optimization and in vitro cytotoxicity studies

other↑,

852-

Gra,

Silver Nanoparticles from Annona muricata Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool

in-vitro,

BC,

MCF-7

2-3ug/mL

AgNPs-PE, AgNPs-LE

in-vitro,

Colon,

HCT116

2ug/mL

AgNPs-PE, AgNPs-LE

in-vitro,

Melanoma,

A375

3-8ug/mL

AgNPs-PE, AgNPs-LE

tumCV↓,

851-

Gra,

Antiproliferation Activity and Apoptotic Mechanism of Soursop (Annona muricata L.) Leaves Extract and Fractions on MCF7 Breast Cancer Cells

in-vitro,

BC,

MCF-7

f 5.3, 2.86, 3.08, and 48.31 µg/mL

ethanol extract, ethyl acetate, n-hexane, and water fractions of A. muricata leaves

in-vitro,

Nor,

CV1

Bcl-2↓, Casp9↑, Casp3↑, other↑, *toxicity↓,

850-

Gra,

Selective cytotoxic and anti-metastatic activity in DU-145 prostate cancer cells induced by Annona muricata L. bark extract and phytochemical, annonacin

in-vitro,

PC,

PC3

0.1uM(Annonacin) 55ug/mL(EAB)

without impacting RWPE-1 normal prostate cells

in-vitro,

Pca,

DU145

ROS∅, MMP∅, Casp3↑, Casp7↑, VEGF↓,

849-

Gra,

Annona muricata silver nanoparticles exhibit strong anticancer activities against cervical and prostate adenocarcinomas through regulation of CASP9 and the CXCL1/CXCR2 genes axis

in-vitro,

Pca,

PC3

 48.17μg/ml

in-vitro,

Nor,

PNT1A

7.8x higher

normal health cells

in-vitro,

NA,

HeLa

Casp9↑, CXCL1↓, *toxicity↓,

848-

Gra,

AgNPs,

Synthesis, Characterization and Evaluation of Antioxidant and Cytotoxic Potential of Annona muricata Root Extract-derived Biogenic Silver Nanoparticles

in-vitro,

CRC,

HCT116

ROS↑, PUMA↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑,

846-

Gra,

Cytotoxic effect of Annona muricata Linn leaves extract on Capan-1 cells

in-vitro,

NA,

Ca9-22

IC25 varied ~7.8-8μg/ml and ~0.9-1.0μg/ml respectively.

other↑,

2437-

Gra,

Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity

in-vitro,

Pca,

LNCaP

1–5 μg/ml

in-vitro,

Pca,

22Rv1

in-vitro,

Pca,

PC3

in-vitro,

Nor,

PWR-1E

NOX↓, selectivity↑,

2438-

Gra,

Emerging therapeutic potential of graviola and its constituents in cancers

Review,

Var,

Hif1a↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, MUC4↓, TumCCA↑, MMP↓, NF-kB↓, ROS↓, Bax:Bcl2↑, ER(estro)↓, cycD1/CCND1↓, chemoPv↑, hepatoP↑,

1234-

Gra,

Graviola attenuates DMBA-induced breast cancer possibly through augmenting apoptosis and antioxidant pathway and downregulating estrogen receptors

in-vivo,

BC,

200 mg/kg body mass

rats

Apoptosis↑, BAX↑, P53↑, Casp3↑, ER-α36↓, lipid-P↓,

1233-

Gra,

THERAPEUTIC ELIGIBILITY OF GRAVIOLA VERSUS 5-FLUOROURACIL: APOPTOTIC EFFICACY ON HEAD AND NECK SQUAMOUS CELL CARCINOMA AND NORMAL EPITHELIUM CELLS

in-vitro,

HNSCC,

(200 μg/ml, 400 μg/ml, 600 μg/ml, 800 μg/ml, and 1000 μg/m

103ug/ml @48hr

Apoptosis↑, MMP↓,

1232-

Gra,

Graviola: A Systematic Review on Its Anticancer Properties

Review,

NA,

oral 100mg/kg

EGFR↓, cycD1/CCND1↓, Bcl-2↓, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, BAX↑, Cyt‑c↑, Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ATP↓,

1241-

GSE,

PACs,

Grape seed proanthocyanidins inhibit angiogenesis via the downregulation of both vascular endothelial growth factor and angiopoietin signaling

in-vitro,

Nor,

*VEGF↓, *MMP2↓, *MMP9↓, *p‑VEGFR2↓,

1240-

GSE,

PACs,

Grape Seed Proanthocyanidins Inhibit Melanoma Cell Invasiveness by Reduction of PGE2 Synthesis and Reversal of Epithelial-to-Mesenchymal Transition

in-vitro,

Melanoma,

A375

in-vitro,

Melanoma,

Hs294T

TumCMig↓, TumCI↓, COX2↓, PGE2↓, NF-kB↓, EMT↓, E-cadherin↑, Vim↓, Fibronectin↓, N-cadherin↓,

1292-

GSE,

EGCG,

Antiproliferative and Apoptotic Effects Triggered by Grape Seed Extract (GSE) versus Epigallocatechin and Procyanidins on Colon Cancer Cell Lines

in-vitro,

Colon,

Caco-2

100ug/L

in-vitro,

CRC,

HCT8

TumCG↓, Apoptosis↑,

1118-

GSE,

Grape Seed Proanthocyanidins Inhibit Migration and Invasion of Bladder Cancer Cells by Reversing EMT through Suppression of TGF- β Signaling Pathway

in-vitro,

Bladder,

T24/HTB-9

in-vitro,

Bladder,

5637

TumCMig↓, TumCI↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Vim↓, Slug↓, E-cadherin↑, ZO-1↑, p‑SMAD2↓, p‑SMAD3↓, p‑Akt↓, p‑ERK↓, p‑p38↓,

108-

GSL,

A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells

in-vitro,

PC,

PANC1

  6.9 uM

in-vitro,

PC,

AsPC-1

  5.1 uM

in-vitro,

PC,

C3H10T1/2

  35.7 uM

HH↓, Gli1↓, cycD1/CCND1↓, TumCP↓,

3768-

H2,

Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial

Trial,

AD,

*ROS↓, *NO↓, *BACE↓, *BDNF↑, *VEGF↑, *p‑tau↓, *MCP1↓, *IL6↓, *cognitive↑, *toxicity∅,

3770-

H2,

Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases

Review,

AD,

Review,

Park,

*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,

3761-

H2,

Therapeutic Inhalation of Hydrogen Gas for Alzheimer's Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study

Human,

AD,

inhaled 3% H2 gas for one hour twice daily for 6 months

*cognitive↑, *BBB↑, *ROS↓, *NRF2↑, *Inflam↓, *NFAT↓, *FAO↓, *4-HNE↓, *PGC-1α↑, *Ferroptosis↓,

3771-

H2,

Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation—Fantasy or Reality?

Review,

AD,

Review,

Stroke,

*cognitive↑, AntiCan↑, *Inflam↓, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *GPx↑, *MDA↑, *BBB↑, *OS↑, *Ca+2↓, *APP↓, *p‑tau↓,

3772-

H2,

Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis

in-vivo,

AD,

zebrafish AD model

*cognitive↑, *Aβ↓, *Inflam↓, *ROS↓, *GutMicro↑, *TNF-α↓, *IL6↓, *IL1β↓, *IL10↓, *Catalase↑, *GSH↑,

3773-

H2,

Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases

Review,

Park,

*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,

3774-

H2,

The role of hydrogen in Alzheimer’s disease

Review,

AD,

*Inflam↓, *antiOx↑, *NLRP3↓, *memory↑, *Aβ↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *p‑p38↓, *JNK↓, *ROS↓, *cognitive↑, *ER(estro)↑, *BDNF↑,

3775-

H2,

Molecular hydrogen therapy for neurological diseases: a review of current evidence

Review,

AD,

Review,

Stroke,

*Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑,

3776-

H2,

The role of hydrogen in Alzheimer's disease

Review,

AD,

*antiOx↑, *Inflam↓, *NLRP3↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *ROS↓, *BDNF↑,

3777-

H2,

Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders

Review,

AD,

Review,

Stroke,

Review,

Park,

*neuroP↑,

3787-

H2,

Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis

Review,

AD,

*Inflam↓, *antiOx↑, *ROS↓, *other↝, *NF-kB↓, *IL2↓, *IL6↓, *TNF-α↓, *HO-1↑, Apoptosis↑, TumAuto↑, *Sepsis↓, *NLRP3↓, Pyro↑,

3762-

H2,

Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment

in-vivo,

AD,

 ~300 mL of H2-water/day

Transgenic mice

*ROS↓, *memory↑, *neuroP↑, *cognitive↑, *OS↑,

3763-

H2,

Long-Term Inhalation of Hydrogen Gas for Patients with Advanced Alzheimer's Disease: A Case Report Showing Improvement in Fecal Incontinence

Case Report,

AD,

3% H2 gas containing 21% oxygen twice daily for 1 hour

*cognitive↑, *neuroP↑,

3764-

H2,

Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model

in-vivo,

AD,

mice

*memory↑, *Aβ↓, *p‑tau↓, *BAX↓, *ROS↓, *NO↓, *Ca+2↓, *MDA↓, *Catalase↓, *GPx↓, *TNF-α↓, *Bcl-2↑, *VEGF↑, *Inflam↓, *cognitive↑,

3765-

H2,

Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study

Study,

AD,

3% H2 gas for one hour twice daily for 6 months

*antiOx↑, *Inflam↓, *cognitive↑, *BBB↑,

3766-

H2,

The role of hydrogen in Alzheimer′s disease

Review,

AD,

*antiOx↑, *Inflam↓, *AMPK↑, *SIRT1↑, *FOXO↑, *mtDam↓, *neuroP↑, *ROS↓, *p38↓, *cognitive↑, *BDNF↑, *memory↑, *lipid-P↓, *IL6↓, *TNF-α↓, *JNK↓, *NF-kB↓, *NLRP3↓,

3767-

H2,

The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges

Review,

AD,

*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE↓, *Aβ↓, *BP∅, *BBB↑,

2511-

H2,

Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation

in-vivo,

GBM,

U87MG

mice

TumCG↓, OS↑, CD133↓, Ki-67↓, angioG↓, Diff↑, TumCMig↓, TumCI↓, Dose↝, BBB↑, mt-ROS↑,

2525-

H2,

Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis

in-vivo,

NA,

rats

OS↓, cardioP↑, *AST↓, ALAT↓, *ROS↓, *MDA↓, *hepatoP↑, *Inflam↓, chemoP↑,

2524-

H2,

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy

Trial,

NA,

 152 patients with CRC

hepatoP↑, ALAT↓, AST↓, Dose↝, Dose↝,

2523-

H2,

Prospects of molecular hydrogen in cancer prevention and treatment

Review,

Var,

ROS↓, TumCP↓, TumMeta↓, AntiTum↑, GutMicro↑, Inflam↓, OS↑, radioP↑, selectivity↑, SOD↑, IL1β↑, IL8↑, TNF-α↑, neuroP↑,

2522-

H2,

A Systematic Review of Molecular Hydrogen Therapy in Cancer Management

Review,

Var,

chemoP↑, OS↑, QoL↑, TumVol↑, ROS↑, AntiTum↑, other↝,

2521-

H2,

Oxyhydrogen Gas: A Promising Therapeutic Approach for Lung, Breast and Colorectal Cancer

Review,

CRC,

Review,

Lung,

Review,

BC,

Inflam↑, ROS↓, ChemoSen↑, p‑PI3K↓, p‑Akt↓, QoL↑, GutMicro↑, chemoP↑, radioP↑, *NRF2↑, *Catalase↑, *GPx↑, *HO-1↑, *SOD↑, *TNF-α↓, *IL4↓, *IL6↓, ChemoSen↑, Appetite↑, cognitive↑, Pain↓, Sleep↑, other?,

2520-

H2,

The Impact of Molecular Hydrogen on Mitochondrial ROS and Apoptosis in Colorectal Cancer Cells

in-vitro,

CRC,

mt-ROS↓, ChemoSen↑, other↝,

2519-

H2,

Hydrogen: an advanced and safest gas option for cancer treatment

Review,

Var,

antiOx↑, neuroP↓, BBB↑, toxicity∅, TumCP↓, Apoptosis↓, ROS↑, Hif1a↓, NF-kB↓, P53?, OS↑, chemoP↑,

2518-

H2,

Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity

in-vitro,

BC,

4T1

CaCO3 nanoparticles-coated magnesium system (Mg-CaCO3) is developed.

in-vitro,

Nor,

3T3

TumCD↑, CD4+↑, ROS↓,

Showing Research Papers: 3651 to 3700 of 6624
Prev Page 74 of 133 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6624

Pathway results for Effect on Cancer / Diseased Cells:

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

4-HNE↓, 1, antiOx↑, 10, Catalase↓, 1, Catalase↑, 4, Ferroptosis↓, 1, GPx↓, 1, GPx↑, 2, GPx1↑, 1, GSH↑, 1, HO-1↑, 4, lipid-P↓, 2, MDA↓, 4, MDA↑, 1, NRF2↑, 5, ROS↓, 14, mt-ROS↓, 1, SIRT3↑, 1, SOD↑, 2, SOD1↑, 1,

Mitochondria & Bioenergetics ⓘ

ATP↑, 1, mtDam↓, 2, PGC-1α↑, 1,

Core Metabolism/Glycolysis ⓘ

AMPK↑, 5, FAO↓, 1, LDL↓, 1, NADPH↓, 2, SIRT1↑, 5,

Cell Death ⓘ

Akt↓, 1, BAX↓, 1, Bcl-2↑, 1, Ferroptosis↓, 1, JNK↓, 2, p38↓, 1, p‑p38↓, 1,

Transcription & Epigenetics ⓘ

other↓, 1, other↝, 1,

Proliferation, Differentiation & Cell State ⓘ

FOXO↑, 1, FOXO3↑, 4, mTOR↓, 1, p‑mTOR↓, 1, PTEN↓, 1,

Migration ⓘ

AntiAg↑, 1, APP↓, 2, Ca+2↓, 2, MMP2↓, 1, MMP9↓, 1, NFAT↓, 1,

Angiogenesis & Vasculature ⓘ

NO↓, 4, VEGF↓, 1, VEGF↑, 2, p‑VEGFR2↓, 1,

Barriers & Transport ⓘ

BBB↑, 5,

Immune & Inflammatory Signaling ⓘ

IL10↓, 1, IL1β↓, 4, IL2↓, 1, IL4↓, 1, IL6↓, 7, Inflam↓, 14, MCP1↓, 1, NF-kB↓, 3, TLR4↓, 1, TNF-α↓, 7,

Synaptic & Neurotransmission ⓘ

BDNF↑, 5, p‑tau↓, 3,

Protein Aggregation ⓘ

Aβ↓, 4, BACE↓, 2, NLRP3↓, 7,

Hormonal & Nuclear Receptors ⓘ

ER(estro)↓, 1, ER(estro)↑, 1,

Clinical Biomarkers ⓘ

AST↓, 1, BP∅, 1, GutMicro↑, 1, IL6↓, 7,

Functional Outcomes ⓘ

cardioP↑, 1, cognitive↑, 13, hepatoP↑, 1, memory↑, 6, neuroP↑, 9, OS↑, 2, toxicity↓, 3, toxicity∅, 1,

Infection & Microbiome ⓘ

Sepsis↓, 3,
Total Targets: 82

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Cancer Database Query Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Transcription & Epigenetics ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Protein Aggregation ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Transcription & Epigenetics ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Synaptic & Neurotransmission ⓘ

Protein Aggregation ⓘ

Hormonal & Nuclear Receptors ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

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