| 1779- | MEL, | Therapeutic Potential of Melatonin Counteracting Chemotherapy-Induced Toxicity in Breast Cancer Patients: A Systematic Review |
| - | Review, | BC, | NA |
| 1778- | MEL, | Melatonin: a well-documented antioxidant with conditional pro-oxidant actions |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
| 1777- | MEL, | Melatonin as an antioxidant: under promises but over delivers |
| - | Review, | NA, | NA |
| 4705- | MEL, | Melatonin: beyond circadian regulation - exploring its diverse physiological roles and therapeutic potential |
| - | Review, | Nor, | NA |
| 995- | MEL, | Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma |
| - | vitro+vivo, | GBM, | NA |
| 971- | MEL, | Melatonin down-regulates HIF-1 alpha expression through inhibition of protein translation in prostate cancer cells |
| - | in-vitro, | Pca, | DU145 | - | in-vitro, | Pca, | PC3 | - | in-vitro, | Pca, | LNCaP |
| 1063- | MEL, | HDAC1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Lung, | PC9 |
| 1042- | MEL, | Melatonin Downregulates PD-L1 Expression and Modulates Tumor Immunity in KRAS-Mutant Non-Small Cell Lung Cancer |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Lung, | H460 | - | in-vitro, | Lung, | LLC1 |
| 1066- | MET, | Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma |
| - | in-vitro, | SCC, | NA |
| 1043- | MET, | immuno, | Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy |
| - | in-vitro, | NA, | NA |
| 994- | MET, | Tumor metabolism destruction via metformin-based glycolysis inhibition and glucose oxidase-mediated glucose deprivation for enhanced cancer therapy |
| - | in-vitro, | Var, | NA |
| 970- | MET, | Metformin suppresses HIF-1α expression in cancer-associated fibroblasts to prevent tumor-stromal cross talk in breast cancer |
| 1204- | MET, | Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Lung, | H1299 |
| 5803- | MET, | carbop, | Metformin, at Concentrations Corresponding to the Treatment of Diabetes, Potentiates the Cytotoxic Effects of Carboplatin in Cultures of Ovarian Cancer Cells |
| - | in-vitro, | Ovarian, | A2780S | - | in-vitro, | Ovarian, | SKOV3 |
| 5804- | MET, | NIV, | Durable Response to Nivolumab Combined With Metformin in Advanced Pancreatic Cancer: A Case Report With Seven Years of Follow-Up. |
| - | Case Report, | PC, | NA |
| 5785- | MET, | Metformin improves healthspan and lifespan in mice |
| - | in-vivo, | Nor, | NA |
| 5796- | MET, | Tumor, whole blood, plasma, and tissue concentrations of metformin in lung cancer patients |
| - | Human, | Lung, | NA |
| 5795- | MET, | Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes |
| - | Review, | AD, | NA | - | Review, | Park, | NA | - | Review, | Diabetic, | NA |
| 5800- | MET, | Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect |
| - | Review, | Var, | NA |
| 2456- | MET, | Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vivo, | NA, | NA |
| 2457- | MET, | Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II |
| - | in-vitro, | Lung, | Calu-1 |
| 2493- | MET, | Metformin Inhibits Gluconeogenesis by a Redox-Dependent Mechanism In Vivo |
| - | in-vivo, | Nor, | NA |
| 2436- | MET, | Metformin alleviates nickel-induced autophagy and apoptosis via inhibition of hexokinase-2, activating lipocalin-2, in human bronchial epithelial cells |
| - | in-vitro, | Nor, | BEAS-2B |
| 2492- | MET, | The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective |
| - | Review, | Nor, | NA |
| 2491- | MET, | Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase |
| - | in-vivo, | Nor, | NA |
| 2376- | MET, | Metformin Inhibits Epithelial-to-Mesenchymal Transition of Keloid Fibroblasts via the HIF-1α/PKM2 Signaling Pathway |
| - | in-vitro, | Nor, | NA |
| 2375- | MET, | Metformin inhibits gastric cancer via the inhibition of HIF1α/PKM2 signaling |
| - | in-vitro, | GC, | SGC-7901 |
| 2371- | MET, | The role of pyruvate kinase M2 in anticancer therapeutic treatments |
| - | Review, | Var, | NA |
| 2377- | MET, | Metformin Inhibits TGF-β1-Induced Epithelial-to-Mesenchymal Transition via PKM2 Relative-mTOR/p70s6k Signaling Pathway in Cervical Carcinoma Cells |
| - | in-vitro, | Cerv, | HeLa | - | in-vitro, | Cerv, | SiHa |
| 2378- | MET, | Metformin inhibits epithelial-mesenchymal transition of oral squamous cell carcinoma via the mTOR/HIF-1α/PKM2/STAT3 pathway |
| - | in-vitro, | SCC, | CAL27 | - | in-vivo, | NA, | NA |
| 2379- | MET, | Down‐regulation of PKM2 enhances anticancer efficiency of THP on bladder cancer |
| - | in-vitro, | Bladder, | T24/HTB-9 | - | in-vitro, | BC, | UMUC3 |
| 2383- | MET, | Activation of AMPK by metformin promotes renal cancer cell proliferation under glucose deprivation through its interaction with PKM2 |
| - | in-vitro, | RCC, | A498 |
| 2374- | MET, | Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions |
| - | in-vitro, | BC, | MCF-7 | - | in-vitro, | BC, | SkBr3 | - | in-vitro, | BC, | MDA-MB-231 |
| 2384- | MET, | Integration of metabolomics and transcriptomics reveals metformin suppresses thyroid cancer progression via inhibiting glycolysis and restraining DNA replication |
| - | in-vitro, | Thyroid, | BCPAP | - | in-vivo, | NA, | NA | - | in-vitro, | Thyroid, | TPC-1 |
| 2385- | MET, | Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model |
| - | in-vitro, | AD, | H4 | - | in-vitro, | NA, | HEK293 | - | in-vivo, | NA, | NA | - | in-vitro, | NA, | SH-SY5Y |
| 2386- | MET, | Mechanisms of metformin inhibiting cancer invasion and migration |
| - | Review, | Var, | NA |
| 2387- | MET, | GEM, | Metformin Increases the Response of Cholangiocarcinoma Cells to Gemcitabine by Suppressing Pyruvate Kinase M2 to Activate Mitochondrial Apoptosis |
| - | in-vitro, | CCA, | HCC9810 |
| 2487- | metroC, | Metronomic Chemotherapy: Possible Clinical Application in Advanced Hepatocellular Carcinoma |
| - | Review, | HCC, | NA |
| 2490- | metroC, | Durable complete response of hepatocellular carcinoma after metronomic capecitabine |
| - | Case Report, | HCC, | NA |
| 2489- | metroC, | capec, | Long-lasting response with metronomic capecitabine in advanced hepatocellular carcinoma |
| - | Case Report, | HCC, | NA |
| 2488- | metroC, | Metronomic S-1 Chemotherapy and Vandetanib: An Efficacious and Nontoxic Treatment for Hepatocellular Carcinoma |
| - | in-vitro, | HCC, | HUH7 | - | in-vivo, | HCC, | NA |
| 2486- | metroC, | capec, | Sustained complete response of advanced hepatocellular carcinoma with metronomic capecitabine: a report of three cases |
| - | Case Report, | HCC, | NA |
| 2250- | MF, | MNPs, | Confronting stem cells with surface-modified magnetic nanoparticles and low-frequency pulsed electromagnetic field |
| - | Review, | NA, | NA |
| 2252- | MF, | HPT, | Cellular Response to ELF-MF and Heat: Evidence for a Common Involvement of Heat Shock Proteins? |
| - | Review, | NA, | NA |
| 2251- | MF, | Rad, | BEMER Electromagnetic Field Therapy Reduces Cancer Cell Radioresistance by Enhanced ROS Formation and Induced DNA Damage |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | HNSCC, | UTSCC15 | - | in-vitro, | CRC, | DLD1 | - | in-vitro, | PC, | MIA PaCa-2 |
| 2242- | MF, | Electromagnetic stimulation increases mitochondrial function in osteogenic cells and promotes bone fracture repair |
| - | in-vitro, | Nor, | NA |
| 2249- | MF, | Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study |
| - | in-vitro, | Nor, | L929 |
| 2248- | MF, | Magnetic fields modulate metabolism and gut microbiome in correlation with Pgc-1α expression: Follow-up to an in vitro magnetic mitohormetic study |
| - | in-vivo, | Nor, | NA |
| 2241- | MF, | Pulsed electromagnetic therapy in cancer treatment: Progress and outlook |
| - | Review, | Var, | NA |
| 2247- | MF, | Effects of Pulsed Electromagnetic Field Treatment on Skeletal Muscle Tissue Recovery in a Rat Model of Collagenase-Induced Tendinopathy: Results from a Proteome Analysis |
| - | in-vivo, | Nor, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:% State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid