Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
3845- Moringa,    Protective effects of Moringa oleifera Lam. leaves against arsenic-induced toxicity in mice
- in-vitro, NA, NA
*eff↑,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *eff↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,
3846- MSM,    Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy
- Human, NA, NA
*Dose↝, *BBB↑, *eff↓,
3848- MSM,    Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway
- in-vitro, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *ER(estro)↑, *NRF2↑, *HO-1↑, *Trx1↑, *TXNIP↓, *MDA↓, *NOX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *BDNF↑, *AChE↓, *p‑tau↓, *Aβ↓,
3849- MSM,    Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing
- Human, Nor, NA
*Dose↝, *AntiAge↑,
3850- MSM,    The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise
- Human, NA, NA
*Inflam↓, *IL1β↓, *NF-kB↓, *NLRP3↓, *ROS↓,
3851- MSM,    Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial
- Trial, Arthritis, NA
*Pain↓, *QoL↑,
3852- MSM,    DMSO modulates CNS function in a preclinical Alzheimer's disease model
- in-vivo, AD, NA
*memory↑, *Mood↑,
1203- MSM,    Methylsulfonylmethane Suppresses Breast Cancer Growth by Down-Regulating STAT3 and STAT5b Pathways
- vitro+vivo, BC, MDA-MB-231
tumCV↓, STAT3↓, STAT5↓, IGF-1↓, Hif1a↓, VEGF↓, Brk/PTK6↓, IGF-1R↓,
1182- MushCha,    Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29 - in-vitro, CRC, SW-620 - in-vitro, CRC, DLD1
Apoptosis↑, TumCG↓, FASN↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, CDK8↓, Ki-67↓,
1170- MushCha,    Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism
- in-vitro, Oral, HSC4
tumCV↓, TumCP↓, TumCCA↑, STAT3↓, Glycolysis↓, MMP↓, TumAuto↑, p38↑, NF-kB↑,
3815- mushLions,    Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*eff↑, *cognitive↑,
3810- mushLions,    Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer’s Disease
- Review, NA, NA
*neuroP↑, *p‑tau↓, *APP↓, *Aβ↓, *ROS↓, *Inflam↓, *NLRP3↓,
3814- mushLions,    Lion's Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model
- in-vitro, AD, NA
*neuroP↑, *cognitive↑, *cognitive∅, *BBB↑, *NGF↑, *BDNF↑, *NO↓, *memory↑, *Aβ↓,
3813- mushLions,    Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice
- in-vitro, AD, NA
*Aβ↓, *cognitive↑, *neuroP↑,
3812- mushLions,    Structural characterization of polysaccharide purified from Hericium erinaceus fermented mycelium and its pharmacological basis for application in Alzheimer's disease: Oxidative stress related calcium homeostasis
- in-vitro, AD, NA
*cognitive↑, *Aβ↓, *p‑tau↓, *ROS↓, *NRF2↓, *Ca+2↝,
3811- mushLions,    Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment
- in-vitro, NA, NA
*memory↑, *BBB↑, *GSH↑, *AChE↓, *MDA↓,
3809- mushLions,    The Monkey Head Mushroom and Memory Enhancement in Alzheimer's Disease
- Review, NA, NA
*cognitive↑, *Apoptosis↓, *Aβ↓, *AChE↓, *BACE↓,
3808- mushLions,    Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging
- in-vitro, NA, NA
*Inflam↓, *ROS↓, *neuroP↑,
3807- mushLions,    Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The “Longevity Vitamin” Improves Locomotor Performances during Aging
*AntiAge↑, *other↑, *NOS2↓, *COX2↓, *P53↑, *neuroP↑,
3806- mushLions,    Dietary Supplementation of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), and Spatial Memory in Wild-Type Mice
- in-vitro, NA, NA
*motorD↑, *memory↑,
2484- mushLions,    Neurotrophic and Neuroprotective Effects of Hericium erinaceus
- Review, Stroke, NA - Review, AD, NA - Review, Park, NA
*eff↑, *BBB↑, *Dose↝, *neuroP↑, *cognitive↑, *toxicity∅,
1573- MushReishi,    Ganoderma lucidum (Reishi mushroom) for cancer treatment
- Review, NA, NA
ChemoSen↑, CR3↝, eff↑, NK cell↑, T-Cell↑, QoL↑,
930- MushShi,    Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation
- in-vitro, Ovarian, NA
p‑STAT3↓, PTPN6↑, cycD1/CCND1↓, Bcl-2↓, Mcl-1↓, survivin↓, VEGF↓,
2- MushShi,    The Effects of Active Hexose Correlated Compound (AHCC) on Levels of CD4+ and CD8+ in Patients with Epithelial Ovarian Cancer or Peritoneal Cancer Receiving Platinum Based Chemotherapy
- Human, Ovarian, NA
CD8+↑, Pain↑,
3- MushShi,    AHCC Activation and Selection of Human Lymphocytes via Genotypic and Phenotypic Changes to an Adherent Cell Type: A Possible Novel Mechanism of T Cell Activation
*LAT↑, *FLRT2↑, *GIT1↑, *T-Cell↑,
1044- Myr,    Myricetin inhibits interferon-γ-induced PD-L1 and IDO1 expression in lung cancer cells
- in-vitro, Lung, NA
PD-L1↓, IDO1↓,
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, NA, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,
1128- Myr,    Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer
- vitro+vivo, Ovarian, NA
MAPK↓, ERK↓, PI3K↓, Akt↓, p‑PARP↑, cl‑Casp3↑, Bax:Bcl2↑, TumCMig↓, SMAD3↓,
1273- Myr,    Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4
- vitro+vivo, GC, NA
Ferroptosis↑, MDA↑, Iron↑, GSH↓, NOX4↑, NRF2↓, GPx4↓,
1998- Myr,  CUR,    Thioredoxin-dependent system. Application of inhibitors
- Review, Var, NA
TrxR↓, ROS↑,
1997- Myr,  QC,    Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity
- in-vitro, Lung, A549
TrxR↓, eff↑, TumCCA↑, eff↓, ROS↑,
116- Myrrh,    The Role of Myrrh Metabolites in Cancer, Inflammation, and Wound Healing: Prospects for a Multi-Targeted Drug Therapy
- in-vitro, AML, HL-60 - in-vitro, AML, K562 - in-vitro, BC, KAIMRC1
ROS↑, M1↑, M2 MC↑, Apoptosis?, BBB↝,
4167- NAC,    N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action
- Review, NA, NA
*GSH↑, *antiOx↑, *ROS↓,
4160- NAD,    The biochemical pathways of central nervous system neural degeneration in niacin deficiency
- Review, NA, NA
*BDNF↑, *TrkB↑,
4035- NAD,  VitB3,    NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING
- in-vitro, AD, NA
*Inflam↓, *DNAdam↓, *NLRP3↓, *cGAS–STING↓,
4036- NAD,  VitB3,    NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
- in-vivo, AD, NA
*Inflam↓, *p‑tau↓, *DNAdam↓, *memory↑, *motorD↑, *cognitive↑, *BBB↑, IL1β↓, *TNF-α↓, *MCP1↓, *RANTES↓, *ROS↓, *SIRT3↑, *SIRT6↑,
2938- NAD,    NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling
- in-vivo, BC, NA
TumMeta↓, SIRT1↑,
2931- NAD,    NAD+ Repletion Rescues Female Fertility during Reproductive Aging
- in-vivo, Nor, NA
*eff↑, *SIRT2↑, *other↑, *Dose↝,
2932- NAD,    Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment
- in-vitro, Nor, NA
*SIRT1↑, *HO-1↑, *neuroP↑, *Apoptosis↓, *Inflam↓, *ROS↓, *antiOx↑, *toxicity↓,
2933- NAD,    Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns
- Review, Nor, NA - NA, AD, NA - NA, Diabetic, NA - NA, Stroke, NA - NA, LiverDam, NA - NA, Park, NA
*mtDam↓, *BioAv↝, *BioAv↑, *OS↑, *eff↑, *eff↑, *cognitive↑, *DNAdam↓, *SIRT1↑, *cardioP↑, *ROS↓, *Dose↝, *BioAv↑, *hepatoP↑, *eff↑, *BG↓, *creat↓,
2934- NAD,    The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial
- Trial, Nor, NA
*Dose↑, *Strength↑,
2935- NAD,    Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner
- in-vitro, Nor, NA
*GutMicro↑, *OS↑,
2936- NAD,    The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
*ROS↓, *DNAdam↓, *neuroP↑, *Inflam↓, *BioAv↑, *SIRT1↑, BioAv↝,
2939- NAD,  Rad,    NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7
- in-vitro, Nor, NA
*SIRT6↑, *DNAdam↓, *radioP↑, *ROS↓,
2937- NAD,    High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway
- in-vitro, Lung, A549
SIRT1↑, Dose↝, TumCP⇅, Ferroptosis↑, lipid-P↑, AMPK↑, ACC↑,
5787- NAD,    Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
- in-vitro, Nor, NA
*CRM↑, *OS↑,
5786- NAD,    Therapeutic potential of NAD-boosting molecules: the in vivo evidence
- Review, Nor, NA
*Dose↝, *eff↑, *cognitive↑, *neuroP↑,
5611- NaHCO3,    NaHCO3 enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells
- vitro+vivo, HCC, HepG2
tumCV↓, TumCG↓, pH↑, eff↑, Imm↑,
5598- NaHCO3,    Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases
- in-vivo, BC, MDA-MB-231
e-pH↑, TumMeta↓, TumCG⇅, Dose↑,

Showing Research Papers: 3851 to 3900 of 5883
Prev Page 78 of 118 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5883

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 2,   GPx4↓, 1,   GSH↓, 1,   Iron↑, 1,   lipid-P↑, 1,   MDA↑, 1,   NOX4↑, 1,   NRF2↓, 1,   ROS↑, 3,   SIRT3↑, 1,   TrxR↓, 2,  

Mitochondria & Bioenergetics ⓘ

MEK↓, 1,   MKK4↓, 1,   MMP↓, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↑, 1,   AMPK↑, 1,   cMyc↓, 1,   FASN↓, 1,   Glycolysis↓, 1,   IDO1↓, 1,   SIRT1↑, 2,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis?, 1,   Apoptosis↑, 2,   Bax:Bcl2↑, 2,   Bcl-2↓, 1,   BMP2↓, 1,   cl‑Casp3↑, 1,   Ferroptosis↑, 2,   MAPK↓, 1,   Mcl-1↓, 1,   necrosis↑, 1,   p38↓, 1,   p38↑, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 4,  

Protein Folding & ER Stress ⓘ

HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 2,  

DNA Damage & Repair ⓘ

p‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 3,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

CDK8↓, 1,   EMT↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   IGF-1?, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   PI3K↓, 1,   PTPN6↑, 1,   STAT3↓, 2,   p‑STAT3↓, 1,   STAT5↓, 1,   TumCG↓, 2,   TumCG⇅, 1,  

Migration ⓘ

Brk/PTK6↓, 1,   F-actin↓, 1,   Ki-67↓, 1,   MMP2↓, 1,   MMP9↓, 1,   SMAD3↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumCP⇅, 1,   TumMeta↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   Hif1a↓, 1,   VEGF↓, 4,  

Barriers & Transport ⓘ

BBB↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CR3↝, 1,   IL1β↓, 1,   Imm↑, 1,   M1↑, 1,   M2 MC↑, 1,   NF-kB↑, 1,   NK cell↑, 1,   PD-L1↓, 1,   T-Cell↑, 1,  

Cellular Microenvironment ⓘ

pH↑, 1,   e-pH↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   ChemoSen↑, 1,   Dose↑, 1,   Dose↝, 1,   eff↓, 1,   eff↑, 3,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   Ki-67↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

Pain↑, 1,   QoL↑, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 96

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 4,   HO-1↑, 2,   MDA↓, 2,   NRF2↓, 1,   NRF2↑, 2,   ROS↓, 12,   SIRT3↑, 1,   SOD↑, 1,   Trx1↑, 1,   uricA↓, 1,  

Mitochondria & Bioenergetics ⓘ

mtDam↓, 1,  

Core Metabolism/Glycolysis ⓘ

CRM↑, 1,   LAT↑, 1,   SIRT1↑, 3,   SIRT2↑, 1,  

Cell Death ⓘ

Akt↑, 1,   Apoptosis↓, 2,   iNOS↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↓, 5,   P53↑, 1,   SIRT6↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↑, 1,   STAT↓, 1,  

Migration ⓘ

APP↓, 1,   Ca+2↝, 1,   Cartilage↑, 1,   FLRT2↑, 1,   GIT1↑, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

BBB↑, 5,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL1↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 9,   MCP1↓, 1,   NF-kB↓, 2,   RANTES↓, 1,   T-Cell↑, 1,   TNF-α↓, 2,  

Cellular Microenvironment ⓘ

cGAS–STING↓, 1,   NOX↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 3,   BDNF↑, 3,   NGF↑, 1,   p‑tau↓, 4,   TrkB↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 6,   BACE↓, 1,   NLRP3↓, 4,  

Hormonal & Nuclear Receptors ⓘ

ER(estro)↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 3,   BioAv↝, 1,   Dose↑, 1,   Dose↝, 7,   eff↓, 1,   eff↑, 10,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

BG↓, 1,   creat↓, 1,   GutMicro↑, 1,   IL6↓, 1,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 2,   cardioP↑, 1,   cognitive↑, 9,   cognitive∅, 1,   hepatoP↑, 1,   memory↑, 5,   Mood↑, 1,   motorD↑, 2,   neuroP↑, 10,   OS↑, 3,   Pain↓, 2,   QoL↑, 1,   radioP↑, 1,   Strength↑, 1,   toxicity↓, 1,   toxicity∅, 1,  
Total Targets: 84

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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