ERK Cancer Research Results

ERK, ERK signaling: Click to Expand ⟱
Source:
Type:
MAPK3 (ERK1)
ERK proteins are kinases that activate other proteins by adding a phosphate group. An overactivation of these proteins causes the cell cycle to stop.
The extracellular signal-regulated kinase (ERK) signaling pathway is a crucial component of the mitogen-activated protein kinase (MAPK) signaling cascade, which plays a significant role in regulating various cellular processes, including proliferation, differentiation, and survival. high levels of phosphorylated ERK (p-ERK) in tumor samples may indicate active ERK signaling and could correlate with aggressive tumor behavior

EEk singaling is frequently activated and is often associated with aggressive tumor behavior, treatment resistance, and poor outcomes.
Scientific Papers found: Click to Expand⟱
2135- TQ,    Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets
- in-vitro, Nor, HaCaT
*HO-1↑, *NRF2↑, *e-ERK↑, *e-Akt↑, *AMPKα↑, *ROS⇅, *eff↓, *tumCV∅,
4173- TQ,    Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons
- in-vivo, NA, NA
*neuroP↑, *Casp3↓, *Apoptosis↓, *ERK↑, *JNK↑, *CREB↑, *iNOS↑, *BDNF∅,
3573- TQ,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, Var, NA
NF-kB↓, XIAP↓, PI3K↓, Akt↓, STAT3↓, JAK2↓, cSrc↓, PCNA↓, MMP2↓, ERK↓, Ki-67↓, Bcl-2↓, VEGF↓, p65↓, COX2/PTGS2↓, MMP9↓,
3411- TQ,    Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone
- Review, Var, NA
p‑STAT3↓, cycD1/CCND1↓, JAK2↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MET↓, p‑Akt↓, p‑mTOR↓, CXCR4↓, Bcl-2↓, BAX↑, ROS↑, Cyt‑c↑, Twist↓, Zeb1↓, E-cadherin↑, p‑p38↑, p‑MAPK↑, ERK↑, eff↑, ERK↓, TumCP↓, TumCMig↓, TumCI↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27/CDKN1B↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,
6452- TUR,    Turmeric Essential Oil Constituents as Potential Drug Candidates: A Comprehensive Overview of Their Individual Bioactivities
- Review, Nor, NA
Dose↝, Casp3↑, MMP9↓, COX2/PTGS2↓, NF-kB↓, PI3K↓, Akt↓, ERK↓, Inflam↓, TNF-α↓, IL6↓, IL17↓, IL22↓, IL23↓,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
2350- UA,    Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Akt↓, Glycolysis↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, AMPK↑, TumAuto↑, Apoptosis↑, ERK↓, MMP↓, NO↑, ROS↑, DNAdam↑,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31/PECAM-1↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
4835- Uro,    Urolithin A, induces apoptosis and autophagy crosstalk in Oral Squamous Cell Carcinoma via mTOR /AKT/ERK1/2 pathway
- in-vitro, SCC, NA
TumCD↑, ER Stress↑, Akt↓, mtDam↓, p‑mTOR↓, *BioAv↝, ROS↑, TumCCA↑, Apoptosis↑, ERK↓,
4837- Uro,    Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review
- Review, Var, NA
AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2/PTGS2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,
3136- VitC,    Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer
- in-vitro, Colon, SW48 - in-vitro, Colon, LoVo
ERK↓, p‑PKM2↓, GLUT1↓, Warburg↓, TumCD↑, eff↑, ROS↓, cMyc↓,
3134- VitC,    Vitamin C promotes human endothelial cell growth via the ERK-signaling pathway
- in-vitro, Nor, HUVECs
*ERK↑,
3135- VitC,    The interplay between vitamin C and thyroid
- Review, Thyroid, NA
AntiCan↑, ChemoSen↑, radioP↑, MAPK↓, ERK↓, PI3K↓, Akt↓, QoL↑, OS↑,
1817- VitK2,    Research progress on the anticancer effects of vitamin K2
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, eff↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27/CDKN1B↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, eff↑, eff↑,
1818- VitK2,    New insights on vitamin K biology with relevance to cancer
- Review, Var, NA
TumCG↓, ChemoSen↑, toxicity∅, OS↑, BMD↑, eff↑, MMP↓, ROS↑, eff↓, ERK↑, JNK↑, p38↑, Cyt‑c↑, Casp↑, ATP↓, lactateProd↑, AMPK↑, Rho↓, TumCG↓, BioAv↑, cardioP↑, Risk↓,
1213- VitK2,    Vitamin K2 Inhibits Hepatocellular Carcinoma Cell Proliferation by Binding to 17β-Hydroxysteroid Dehydrogenase 4
- in-vitro, HCC, HepG2
HSD17B4↓, Akt↓, MEK↓, ERK↓, STAT3↓, TumCP↓,
2281- VitK2,    The biological responses of vitamin K2: A comprehensive review
- Review, Var, NA
*ROS↓, *12LOX↓, *NF-kB↓, *BMD↑, *hepatoP↑, cycD1/CCND1↓, PKCδ↓, STAT3↓, ERK↑, MAPK↓, ROS↑, PI3K↝, Akt↝, Hif1a↝, *neuroP↑,
7916- VT,    Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway
- in-vitro, HCC, NA
*antiOx↑, *Inflam↓, *AntiTum↑, Apoptosis↑, Casp3↑, Bcl-2↓, LC3II↓, p‑JNK↑, p‑ERK↓,
7887- VT,  IVT,    Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,
1222- Z,    Zinc regulates primary ovarian tumor growth and metastasis through the epithelial to mesenchymal transition
- in-vitro, Ovarian, NA
EMT↑, TumCMig↑, TumCI↑, ERK↑, Akt↑,

Showing Research Papers: 351 to 374 of 374
Prev Page 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 374

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   H2O2↑, 1,   lipid-P↑, 1,   ROS↓, 2,   ROS↑, 7,   ROS⇅, 2,   i-ROS↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 3,   CDC2↓, 1,   CDC25↓, 1,   MEK↓, 1,   mitResp↓, 1,   MMP↓, 6,   mtDam↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 4,   ATG7↑, 1,   cMyc↓, 5,   FAO↑, 1,   FASN↓, 1,   Glycolysis↓, 2,   HK2↓, 2,   HSD17B4↓, 1,   lactateProd↓, 2,   lactateProd↑, 1,   PKM2↓, 2,   p‑PKM2↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 12,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 10,   Bak↑, 1,   BAX↑, 6,   Bcl-2↓, 8,   Bcl-2↑, 1,   Bcl-xL↓, 2,   BID↓, 1,   Casp↑, 2,   Casp3↑, 8,   Casp7↑, 1,   Casp8↑, 3,   Casp9↑, 4,   Chk2↓, 1,   Cyt‑c↑, 3,   DR5↑, 1,   Fas↑, 1,   iNOS↓, 2,   JNK↑, 4,   p‑JNK↑, 1,   MAPK↓, 5,   MAPK↑, 1,   p‑MAPK↑, 1,   Mcl-1↓, 1,   Myc↓, 1,   p27/CDKN1B↑, 4,   p38↑, 4,   p‑p38↑, 1,   survivin↓, 2,   TRAIL↑, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,   other↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

eIF2α↓, 1,   ER Stress↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3II↓, 1,   LC3II↑, 2,   p62↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   CHK1↓, 1,   CYP1B1↑, 1,   DNAdam↑, 4,   DNMT1↓, 2,   DNMT3A↓, 1,   p16↑, 1,   P53↑, 6,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 2,   PCNA↓, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 6,   E2Fs↓, 1,   E2Fs↑, 1,   P21↓, 1,   P21↑, 4,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cMET↓, 1,   CSCs?, 1,   CSCs↓, 1,   EMT↓, 2,   EMT↑, 1,   ERK↓, 15,   ERK↑, 4,   p‑ERK↓, 4,   FOXO↑, 1,   GSK‐3β↓, 2,   HDAC↓, 1,   HDAC1↓, 2,   HDAC4↓, 1,   miR-34a↑, 1,   mTOR↓, 3,   p‑mTOR↓, 2,   NOTCH↓, 1,   P70S6K↓, 1,   PI3K↓, 8,   PI3K↝, 1,   p‑PI3K↓, 1,   PTEN↑, 2,   RAS↓, 2,   STAT3↓, 7,   p‑STAT3↓, 1,   TumCG↓, 3,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AP-1↓, 1,   Ca+2↑, 2,   CD31/PECAM-1↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 2,   FAK↓, 1,   ITGA5↓, 1,   Ki-67↓, 2,   MET↓, 1,   MMP2↓, 3,   MMP7↓, 2,   MMP9↓, 4,   MMPs↓, 3,   N-cadherin↓, 2,   PKCδ↓, 2,   Rho↓, 1,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 2,   TumCI↑, 1,   TumCMig↓, 2,   TumCMig↑, 1,   TumCP↓, 7,   TumMeta↓, 3,   Twist↓, 4,   Vim↓, 2,   Zeb1↓, 3,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 2,   EGFR↓, 1,   Hif1a↓, 2,   Hif1a↝, 1,   NO↑, 2,   VEGF↓, 5,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   CXCL1↓, 1,   CXCR4↓, 2,   HMGB1↓, 1,   IKKα↓, 1,   IL1↓, 1,   IL10↓, 1,   IL12↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL6↓, 3,   Inflam↓, 3,   JAK2↓, 3,   NF-kB↓, 7,   p‑NF-kB↑, 1,   p65↓, 2,   TNF-α↓, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 6,   Dose↝, 1,   eff↓, 1,   eff↑, 7,   selectivity↑, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BMD↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   EGFR↓, 1,   GutMicro↑, 1,   IL6↓, 3,   Ki-67↓, 2,   Maspin↑, 1,   Myc↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 2,   ChemoSideEff↓, 1,   hepatoP↑, 2,   neuroP↑, 1,   OS↑, 2,   QoL↑, 1,   radioP↑, 2,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 1,   toxicity∅, 2,  
Total Targets: 225

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   H+/K+-ATPase↓, 1,   IRes↝, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↑, 3,   Ferroptosis↓, 1,   GPx↑, 5,   GPx4↑, 1,   GSH↑, 3,   GSTA1↑, 1,   GSTs↑, 3,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 2,   MDA↓, 1,   MFN2↑, 1,   MPO↓, 1,   NADH↓, 1,   NRF2↑, 2,   RNS↓, 1,   ROS↓, 3,   ROS⇅, 1,   SOD↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   DRP1/DNM1L↓, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   AMPK↑, 1,   CREB↑, 1,   GlucoseCon↑, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   e-Akt↑, 1,   Apoptosis↓, 1,   ATF2↑, 1,   Casp3↓, 2,   Ferroptosis↓, 1,   iNOS↑, 1,   JNK↑, 1,   MAPK↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 1,   tumCV∅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 2,   e-ERK↑, 1,   FOXO3↑, 1,   GSK‐3β↑, 1,   HH↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   MMP13↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 2,   IL1β↓, 1,   Imm↑, 1,   Inflam↓, 4,   NF-kB↓, 1,   PGE2↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,   BDNF∅, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 4,   BioAv↝, 5,   eff↓, 1,   eff↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   BP↓, 1,   GutMicro↑, 1,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 3,   neuroP↑, 3,   Obesity↓, 3,   RenoP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  
Total Targets: 88

Scientific Paper Hit Count for: ERK, ERK signaling
16 Berberine
16 Curcumin
15 Fisetin
14 Quercetin
13 Sulforaphane (mainly Broccoli)
12 Silymarin (Milk Thistle) silibinin
11 Shikonin
10 EGCG (Epigallocatechin Gallate)
10 Magnetic Fields
9 Apigenin (mainly Parsley)
9 Thymoquinone
8 Baicalein
7 Artemisinin
7 Caffeic acid
7 Formononetin
6 Luteolin
6 Propolis -bee glue
6 Honokiol
6 Isobavachalcone
6 Lycopene
5 Alpha-Lipoic-Acid
5 Radiotherapy/Radiation
5 Chrysin
5 Piperine
5 Resveratrol
4 Silver-NanoParticles
4 Allicin (mainly Garlic)
4 Astaxanthin
4 Carvacrol
4 Emodin
4 Fucoidan
4 Garcinol
4 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
4 isoorientin
4 Rosmarinic acid
4 Vitamin K2
3 Cisplatin
3 Berbamine
3 Boswellia (frankincense)
3 Chlorogenic acid
3 Cynaropicrin
3 Ferulic acid
3 Hyperoside
3 Inositol
3 Phenethyl isothiocyanate
3 Piperlongumine
3 Ursolic acid
3 Vitamin C (Ascorbic Acid)
2 Andrographis
2 Ashwagandha(Withaferin A)
2 beta-glucans
2 Beta-Caryophyllene
2 Betulinic acid
2 Bromelain
2 Boron
2 Zinc
2 Capsaicin
2 Thymol-Thymus vulgaris
2 chaetocin
2 Crocetin
2 Cucurbitacin
2 Deguelin
2 Dandelion Root
2 Paclitaxel/Taxol
2 Gambogic Acid
2 Geraniol
2 Ginger/6-Shogaol/Gingerol
2 Ginkgetin
2 isoquercitrin
2 Kaempferol
2 Magnetic Field Rotating
2 Myricetin
2 Nimbolide
2 Phenylbutyrate
2 Pterostilbene
2 Sanguinarine
2 Salvia miltiorrhiza
2 Urolithin
2 Vitexin
1 1,8-Cineole
1 Camptothecin
1 alpha Linolenic acid
1 Anethole/trans-Anethole
1 Ascorbyl Palmitate
1 Trastuzumab
1 Baicalin
1 Biochanin A
1 Bacopa monnieri
1 brusatol
1 α-Bisabolol / Chamomile oil
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorophyllin
1 Cinnamon
1 Citric Acid
1 Coenzyme Q10
1 Vitamin E
1 Copper and Cu NanoParticles
1 gefitinib, erlotinib
1 Photodynamic Therapy
1 Bicalutamide
1 Dihydrocaffeic Acid
1 Docosahexaenoic Acid
1 Dipyridamole
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 eicosapentaenoic acid
1 Evodiamine
1 flavonoids
1 Metformin
1 5-fluorouracil
1 Gallic acid
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Ginseng
1 Graviola
1 Grapeseed extract
1 Hydrogen Gas
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 Huperzine A/Huperzia serrata
1 Isoliquiritigenin
1 Morin
1 Mung Bean Sprouts
1 Magnolol
1 Methyl salicylate / Sweet Birch oil
1 Naringin
1 Niclosamide (Niclocide)
1 Oleocanthal
1 Oxygen, Hyperbaric
1 SonoDynamic Therapy UltraSound
1 Hyperthermia
1 Plumbagin
1 Salvia officinalis
1 Aromatherapy
1 Aflavin-3,3′-digallate
1 Tomatine
1 Turmerones
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:105  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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