neuroP Cancer Research Results

neuroP, neuroprotective: Click to Expand ⟱
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Neuroprotective refers to the ability of a substance, intervention, or strategy to preserve the structure and function of nerve cells (neurons) against injury or degeneration.
-While cancer and neurodegenerative processes might seem distinct, there is significant overlap in terms of treatment-related neurotoxicity, shared molecular mechanisms, and the potential for therapies that provide neuroprotection during cancer treatment.
Scientific Papers found: Click to Expand⟱
3922- PTS,    Pterostilbene attenuates amyloid-β induced neurotoxicity with regulating PDE4A-CREB-BDNF pathway
- in-vivo, AD, NA
*BioAv↑, *BBB↑, *memory↑, *p‑CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
4297- QC,    Quercetin attenuates tau hyperphosphorylation and improves cognitive disorder via suppression of ER stress in a manner dependent on AMPK pathway
- in-vitro, AD, SH-SY5Y
*AMPK↑, *IRE1↓, *p‑PERK↓, *p‑tau↓, *cognitive↑, *antiOx↑, *ER Stress↓, *Inflam↓, *neuroP↑, *TXNIP↓, *NLRP3↓,
4162- QC,    Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway
- in-vivo, Stroke, NA
*neuroP↑, *BDNF↑, *TrkB↑, *p‑Akt↑,
3607- QC,    Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
- Review, AD, NA - Review, Park, NA
*neuroP↑, *NRF2↑, *PONs↑, *antiOx↑, *Inflam↓, *SIRT1↑, *eff↑, *ROS↓, *cognitive↑, *eff↑, *lipid-P↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑,
3601- QC,    Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid
- Review, Var, NA - Review, AD, NA
*Inflam↓, *cardioP↑, AntiCan↑, AntiTum↑, *neuroP↑, *cognitive↑, *ROS↓, *BP↓, *LDL↓,
3602- QC,    The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice
- in-vivo, AD, NA
*BACE↓, *cognitive↑, *ROS↓, *lipid-P↓, *iNOS↓, *COX2↓, *BBB↑, *neuroP↑, *other↓, *memory↑,
3603- QC,    Mechanism of quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus
- Review, AD, NA - Review, Diabetic, NA
*MAPK↓, *neuroP↑, *ROS↓, *Akt↓, *PI3K↓, *IL6↓, *TNF-α↓, *VEGF↓, *EGFR↓, *Casp3↓, *Bcl-2↓, *IL1β↓,
3604- QC,    Quercetin enrich diet during the early-middle not middle-late stage of alzheimer’s disease ameliorates cognitive dysfunction
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *neuroP↑, *BACE↓, *p‑SMAD2↓, *p‑STAT3↓, *SPARC↓,
3380- QC,    Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases
- Review, Var, NA - Review, Park, NA - Review, AD, NA
JAK↓, STAT↓, Inflam↓, NO↓, COX2↓, CRP↓, selectivity↑, *neuroP↑, STAT3↓, cycD1/CCND1↓, MMP2↓, STAT4↓, JAK2↓, TumCP↓, Diff↓, *eff↑, *IL6↓, *TNF-α↓, *IL1β↓, *Aβ↓,
3353- QC,    Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
- in-vitro, Oral, KON - in-vitro, Nor, MRC-5
tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,
3351- QC,    Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and Aβ Aggregates in Hippocampal Neurons: the Role of Mitochondria
- Review, AD, NA
*ROS↓, *neuroP↑,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *eff↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *lipid-P↓, *antiOx↑, *Aβ↓, *Inflam↓, *BBB↝, *NF-kB↓, *iNOS↓, *memory↑, *cognitive↑, *AChE↓, *MMP↑, *ROS↓, *ATP↑, *AMPK↑, *NADPH↓, *p‑tau↓,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *GSH↑, *ROS↓, *Dose↑, *NADPH↓, *AMP↓, *NF-kB↓, *p38↑, *MAPK↑, *SOD↑, *MDA↓, *iNOS↓, *Catalase↑, *PI3K↑, *Akt↑, *lipid-P↓, *memory↑, *radioP↑, *neuroP↑, *MDA↓,
3374- QC,    Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis
- Review, Oral, NA - Review, AD, NA
α-SMA↓, α-SMA↑, TumCP↓, tumCV↓, TumVol↓, TumCI↓, TumMeta↓, TumCMig↓, ROS↑, Apoptosis↑, BioAv↓, *neuroP↑, *antiOx↑, *Inflam↓, *Aβ↓, *cardioP↑, MMP↓, Cyt‑c↑, MMP2↓, MMP9↓, EMT↓, MMPs↓, Twist↓, Slug↓, Ca+2↑, AIF↑, Endon↑, P-gp↓, LDH↑, HK2↓, PKA↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, GRP78/BiP↑, Casp12↑, CHOP↑,
3367- QC,    Targeting Nrf2 signaling pathway by quercetin in the prevention and treatment of neurological disorders: An overview and update on new developments
- Review, Stroke, NA - Review, AD, NA
*NRF2↑, *neuroP↑, *motorD↑, *Inflam↓, *cognitive↑,
4153- RES,    Effect of oral resveratrol on the BDNF gene expression in the hippocampus of the rat brain
- in-vivo, AD, NA
*neuroP↑, *BDNF↑,
4154- RES,    Resveratrol improves postnatal hippocampal neurogenesis and brain derived neurotrophic factor in prenatally stressed rats
- in-vivo, AD, NA
*neuroP↑, *BDNF↑,
3612- RES,    Resveratrol in Alzheimer's disease: a review of pathophysiology and therapeutic potential
- Review, AD, NA
*other↑, *Aβ↓, *Inflam↓, *NF-kB↓, *neuroP↑, *HO-1↑, *lipid-P↓, *COX2↓, *AMPK↑, *Catalase↑, *SOD↑, *GSR↑, *ROS↓, *MMP9↓, *cognitive↑, *SIRT1↑, *IL1β↓, *IL6↓,
3614- RES,    Resveratrol--a boon for treating Alzheimer's disease?
- Review, AD, NA
*SIRT1↑, *neuroP↑,
3858- RES,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
*neuroP↑, *antiOx↑, *LDL↓, *ADAM10↑,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, eff↑, HK2↓, ROS↑, MMP↓,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
2567- RES,    Neuroprotective Effects of Resveratrol in Ischemic Brain Injury
- Review, Stroke, NA
*eff↑, *neuroP↑, *antiOx↑, *Inflam↓, *cardioP↑, *AntiAg↑,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF-7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, eff↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3099- RES,    Resveratrol and cognitive decline: a clinician perspective
- Review, Nor, NA - NA, AD, NA
*antiOx↑, *ROS↓, *cognitive↑, *neuroP↑, *SIRT1↑, *AMPK↑, *GPx↑, *HO-1↑, *GSK‐3β↑, *COX2↓, *PGE2↓, *NF-kB↓, *NO↓, *Casp3↓, *MMP3↓, *MMP9↓, *MMP↑, *GSH↑, *other↑, *BioAv↑, *memory↑, *GlutMet↑, *BioAv↓, *Half-Life↓, *toxicity∅,
3100- RES,    Neuroprotective effects of resveratrol in Alzheimer disease pathology
- Review, AD, NA
*neuroP↑, *BioAv↓, *Half-Life↓, *BioAv↑, *BBB↑, *NRF2↑, *BioAv↓, *BioAv↑, *SIRT1↑, *cognitive↑, *lipid-P↓, *HO-1↑, *SOD↑, *GSH↑, *GPx↑, *G6PD↑, *PPARγ↑, *AMPK↑, *Aβ↓,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
4289- RES,    Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells
- in-vitro, AD, NA
*antiOx↑, *p‑tau↓, *GSK‐3β↓, *CaMKII ↓, *PP2A↑, *neuroP↑,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE↓,
4284- RES,    Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
- in-vitro, AD, HEK293 - NA, Stroke, NA - in-vivo, AD, NA
*p‑tau↓, *PP2A↑, *neuroP↑, *antiOx↑, COX2↓, *AntiAg↑, *SIRT1↑, *AMPK↑, *Acetyl-CoA↓, *FAO↑, *ADAM10↑, *BACE↓, *Aβ↓, *memory↑, *Inflam↓, *ROS↓,
3731- RF,    Electromagnetic field treatment protects against and reverses cognitive impairment in Alzheimer's disease mice
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *neuroP↑, *memory↑,
3615- RosA,    Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer's Disease, Parkinson's Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome
- Review, AD, NA - Review, Park, NA
*NLRP3↓, *Inflam↓, *neuroP↑, *NRF2↑, *TNF-α↓, *NF-kB↓, *HO-1↑, *ROS↓,
1745- RosA,    Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications
- Review, Var, NA - Review, AD, NA
ChemoSideEff↓, ChemoSen↑, antiOx↑, MMP2↓, MMP9↓, p‑AMPK↑, DNMTs↓, tumCV↓, COX2↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, Casp3↑, Casp9↓, ROS↓, GSH↑, ERK↓, Akt↓, ROS↓, NF-kB↓, p‑IκB↓, p50↓, p65↓, neuroP↑, Dose↝,
3022- RosA,    Rosmarinic acid against cognitive impairment via RACK1/HIF-1α regulated microglial polarization in sepsis-surviving mice
- in-vitro, Sepsis, NA
*cognitive↑, *neuroP↑, *GlucoseCon↑, *Hif1a↓,
3014- RosA,    Rosmarinic Acid Supplementation Acts as an Effective Antioxidant for Restoring the Antioxidation/Oxidation Balance in Wistar Rats with Cadmium-Induced Toxicity
- in-vivo, Nor, NA
*antiOx↑, *Thiols↑, *GSH↑, *TAC↑, *SOD↑, *GPx↑, *Catalase↑, *ALP↓, *ALAT↓, *AST↓, *creat↓, *BUN↓, *H2O2↓, *MDA↓, *ROS↓, cardioP↑, hepatoP↑, neuroP↑,
3007- RosA,    Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action
- Review, NA, NA
*ROS↓, *lipid-P↓, *Inflam↓, *neuroP↑, *angioG↓, *eff↑, *AST↓, *ALAT↓, *GSSG↓, *eNOS↓, *iNOS↓, *NO↓, *NF-kB↓, *MMP2↓, *MDA↓, *TNF-α↓, *GSH↑, *SOD↑, *IL6↓, *PGE2↓, *COX2↓, *mTOR↑,
3006- RosA,    Rosmarinic acid attenuates glioblastoma cells and spheroids’ growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229
TumCG↓, EMT↓, SIRT1↓, FOXO1↓, NF-kB↓, angioG↓, ROS↓, PTEN↓, PI3K↓, Akt↓, *Inflam↓, *cardioP↑, *hepatoP↑, *neuroP↑, Warburg↓,
3003- RosA,    Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, FOXM1↓, cycD1/CCND1↓, CDK4↓, MMP9↓, HDAC2↓,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,
3039- RosA,    Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs
- in-vivo, Nor, NA - in-vivo, Stroke, NA
*Ferroptosis↓, *GPx4↑, *ACSL4↓, *BBB↑, *IronCh↑, *TfR1/CD71↓, *neuroP↑,
3028- RosA,    Network pharmacology mechanism of Rosmarinus officinalis L.(Rosemary) to improve cell viability and reduces apoptosis in treating Alzheimer’s disease
- in-vitro, AD, HT22 - in-vivo, NA, NA
*Aβ↓, *Apoptosis↓, *antiOx↑, *neuroP↑, *eff↑, *IGF-1↑, *MMP9↑, *Src↓, *MAPK↓, *MMP↑,
3937- RT,    Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease
- in-vivo, AD, NA
*p‑tau↓, *Inflam↓, *NF-kB↓, *cognitive↑, *Aβ↓, *memory↑, *neuroP↑, *BioAv↓, *BBB↑,
3934- RT,    Rutin: A Potential Therapeutic Agent for Alzheimer Disease
- Review, AD, NA
*ROS↓, *Aβ↓, *neuroP↑, *memory↑, *GSH↑, *SOD↑, *lipid-P↓, *MDA↓, *IL1β↓, *IL6↓, *cognitive↑, *BBB↑, *MAPK↑, *IL8↓, *COX2↓, *NF-kB↓, *iNOS↓,
3933- RT,    The Pharmacological Potential of Rutin
- Review, AD, NA - Review, Stroke, NA - Review, Arthritis, NA
*antiOx↑, *neuroP↑, *cardioP↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL8↓, *COX2↓, *iNOS↓, *NF-kB↓, *cognitive↑, *Cartilage↑, *AntiAg↑, *ROS↓, *lipid-P↓, *hepatoP↑, *ALAT↓, *AST↓, *RenoP↑,
4217- Sage,  RosA,  Aroma,    Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender
- Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *ERK↑, *CREB↑, *BDNF↑, *Aβ↑, *AChE↓, *memory↑, *cognitive↑,
6063- SeNPs,    Large Amino Acid Mimicking Selenium-Doped Carbon Quantum Dots for Multi-Target Therapy of Alzheimer's Disease
- in-vivo, AD, NA
*eff↑, *BioAv↑, *ROS↓, *Aβ↓, *memory↓, *neuroP↑, *BBB↑, *cognitive↑,

Showing Research Papers: 351 to 400 of 518
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 518

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 3,   HO-1↑, 2,   lipid-P↓, 1,   NRF2↑, 2,   ROS↓, 5,   ROS↑, 4,   ROS↝, 1,   mt-ROS↑, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 2,   ATP↓, 1,   ATP↑, 1,   MMP↓, 6,  

Core Metabolism/Glycolysis ⓘ

AMPK↓, 1,   AMPK↑, 1,   p‑AMPK↑, 1,   cMyc↓, 3,   GlucoseCon↓, 4,   GlutMet↓, 1,   Glycolysis↓, 2,   HK2↓, 3,   lactateProd↓, 4,   LDH↑, 1,   NADPH↓, 1,   PFK↓, 1,   POLD1↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,   SIRT2↓, 1,   Warburg↓, 4,  

Cell Death ⓘ

Akt↓, 7,   p‑Akt↓, 1,   Apoptosis↑, 6,   BAX↓, 1,   BAX↑, 2,   Bcl-2↓, 3,   Bcl-xL↓, 1,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 3,   Casp9↓, 1,   Casp9↑, 1,   CK2↓, 1,   Cyt‑c↑, 3,   Endon↑, 1,   MAPK↓, 1,   MDM2↓, 2,   p38↓, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 5,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,   BNIP3↑, 1,   p62↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   DNMTs↓, 1,   P53↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 1,   TP53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   P21↓, 1,   P21↑, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CD24↓, 1,   CD44↓, 2,   CSCs↓, 2,   Diff↓, 1,   EMT↓, 6,   ERK↓, 2,   p‑ERK↓, 1,   FOXM1↓, 1,   FOXO1↓, 1,   FOXO4↓, 1,   HDAC2↓, 2,   IGF-1↓, 1,   IGF-1R↓, 1,   mTOR↓, 2,   Nanog↓, 1,   Nestin↓, 1,   PI3K↓, 4,   PTEN↓, 1,   PTEN↑, 2,   RAS↓, 1,   Shh↓, 1,   STAT↓, 1,   STAT3↓, 3,   STAT4↓, 1,   TCF↓, 1,   TOP2↓, 2,   TumCG↓, 2,   Wnt↓, 2,  

Migration ⓘ

Ca+2↑, 2,   E-cadherin↑, 4,   Fibronectin↓, 1,   GIT1↓, 1,   Ki-67↓, 1,   KRAS↓, 1,   MALAT1↓, 1,   MARK4↓, 1,   MMP2↓, 6,   MMP7↓, 2,   MMP9↓, 5,   MMPs↓, 4,   N-cadherin↓, 1,   PKA↓, 1,   PKCδ↓, 1,   Slug↓, 3,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 4,   TumCMig↓, 3,   TumCP↓, 7,   TumMeta↓, 6,   Twist↓, 2,   Vim?, 1,   Vim↓, 2,   Zeb1↓, 2,   α-SMA↓, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   EGFR↓, 1,   Hif1a↓, 4,   NO↓, 1,   VEGF↓, 5,  

Barriers & Transport ⓘ

GLUT1↓, 1,   P-gp↓, 2,   P-gp↑, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↑, 1,   COX2↓, 5,   CRP↓, 2,   CXCR4↓, 1,   ICAM-1↓, 1,   IL1β↓, 1,   IL6↓, 2,   IL6↑, 1,   Inflam↓, 2,   p‑IκB↓, 1,   JAK↓, 1,   JAK2↓, 1,   NF-kB↓, 4,   p50↓, 1,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 1,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioEnh?, 1,   ChemoSen↑, 5,   ChemoSen⇅, 1,   Dose↝, 2,   eff↑, 11,   MDR1↓, 2,   P450↓, 1,   RadioS↑, 2,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

AR↓, 1,   CRP↓, 2,   EGFR↓, 1,   FOXM1↓, 1,   IL6↓, 2,   IL6↑, 1,   Ki-67↓, 1,   KRAS↓, 1,   LDH↑, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   cardioP↑, 2,   ChemoSideEff↓, 1,   hepatoP↑, 1,   neuroP↑, 2,   TumVol↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 196

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 23,   Catalase↑, 7,   Ferroptosis↓, 1,   GPx↑, 6,   GPx4↑, 1,   GSH↑, 12,   GSR↑, 1,   GSSG↓, 1,   GSTs↑, 1,   H2O2↓, 3,   HO-1↑, 11,   HO-1⇅, 1,   Keap1↓, 2,   lipid-P↓, 13,   mt-lipid-P↓, 1,   MDA↓, 8,   Mets↝, 1,   MPO↓, 1,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 12,   ROS↓, 27,   ROS↑, 1,   SOD↑, 11,   SOD2↑, 1,   TAC↑, 1,   Thiols↑, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 2,   MMP↓, 1,   MMP↑, 5,   PGC-1α↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

Acetyl-CoA↓, 1,   ACSL4↓, 1,   ALAT↓, 3,   AMP↓, 1,   AMPK↑, 8,   BUN↓, 1,   CREB↑, 1,   p‑CREB↑, 2,   FAO↑, 1,   G6PD↑, 1,   GlucoseCon↑, 1,   GlutMet↑, 1,   LDL↓, 2,   NADH:NAD↑, 1,   NADPH↓, 2,   PONs↑, 1,   PPARγ↑, 2,   SIRT1↑, 10,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↑, 1,   Apoptosis↓, 2,   BAX↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp3↓, 2,   Cyt‑c∅, 1,   Ferroptosis↓, 1,   iNOS↓, 8,   p‑JNK↓, 1,   MAPK↓, 3,   MAPK↑, 2,   p38↓, 1,   p38↑, 1,  

Kinase & Signal Transduction ⓘ

CaMKII ↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 2,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,   HSP70/HSPA5↝, 1,   IRE1↓, 1,   p‑PERK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   FOXO↑, 1,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   IGF-1↑, 1,   mTOR↑, 1,   PI3K↓, 1,   PI3K↑, 2,   Src↓, 1,   p‑STAT3↓, 1,  

Migration ⓘ

AntiAg↑, 5,   AP-1↓, 1,   Ca+2↓, 1,   Cartilage↑, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 4,   MMP9↑, 1,   PKA↑, 1,   PKCδ↓, 1,   p‑SMAD2↓, 1,   SPARC↓, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   angioG↑, 1,   EGFR↓, 1,   eNOS↓, 1,   Hif1a↓, 1,   NO↓, 2,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↓, 1,   BBB↑, 7,   BBB↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 11,   CRP↓, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↑, 1,   IKKα↓, 1,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 11,   IL6↓, 9,   IL8↓, 2,   Inflam↓, 23,   MCP1↓, 1,   NF-kB↓, 14,   p65↓, 1,   PGE2↓, 3,   TLR4↓, 1,   TLR4↑, 1,   TNF-α↓, 10,  

Synaptic & Neurotransmission ⓘ

AChE↓, 4,   ADAM10↑, 2,   BChE↓, 1,   BDNF↑, 6,   PSD95↑, 1,   tau↓, 1,   p‑tau↓, 6,   TrkB↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 16,   Aβ↑, 1,   BACE↓, 4,   NLRP3↓, 4,   PP2A↑, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 7,   BioAv↑, 11,   BioAv↝, 1,   Dose↑, 1,   Dose↝, 1,   eff↑, 11,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 1,   P450↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 3,   ALP↓, 1,   AST↓, 3,   BG↓, 1,   BP↓, 4,   creat↓, 1,   CRP↓, 1,   EGFR↓, 1,   GutMicro↑, 1,   IL6↓, 9,  

Functional Outcomes ⓘ

AntiAge↑, 2,   AntiCan↑, 1,   cardioP↑, 12,   cognitive↑, 18,   hepatoP↑, 6,   memory↓, 1,   memory↑, 15,   motorD↓, 1,   motorD↑, 2,   neuroP↑, 48,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 2,   toxicity↓, 1,   toxicity∅, 1,  
Total Targets: 177

Scientific Paper Hit Count for: neuroP, neuroprotective
21 Thymoquinone
20 Alpha-Lipoic-Acid
19 Resveratrol
18 Magnetic Fields
18 Quercetin
16 Silymarin (Milk Thistle) silibinin
15 Urolithin
14 Chlorogenic acid
14 Hydrogen Gas
12 Curcumin
12 Rosmarinic acid
11 Baicalein
11 Lycopene
10 Ashwagandha(Withaferin A)
10 Carvacrol
9 Berberine
9 Bacopa monnieri
9 Ferulic acid
9 Honokiol
8 Moringa oleifera
8 Sulforaphane (mainly Broccoli)
7 Allicin (mainly Garlic)
7 Chrysin
7 Piperine
7 Huperzine A/Huperzia serrata
7 Taurine
6 Apigenin (mainly Parsley)
6 Selenium NanoParticles
6 EGCG (Epigallocatechin Gallate)
6 Fisetin
6 Ginseng
6 Mushroom Lion’s Mane
6 Phenylbutyrate
6 Silicic Acid
5 Astaxanthin
5 Vitamin C (Ascorbic Acid)
5 Capsaicin
5 Crocetin
5 Luteolin
5 Piperlongumine
5 Shankhpushpi
5 Shikonin
5 Vitamin E
5 Vitamin B5,Pantothenic Acid
4 Boron
4 Boswellia (frankincense)
4 Carnosic acid
4 Carnosine
4 Propolis -bee glue
4 Folic Acid, Vit B9
4 Shilajit/Fulvic Acid
4 Magnetic Field Rotating
4 Pterostilbene
4 Vitamin B12
3 Anthocyanins
3 Artemisinin
3 Biochanin A
3 Betulinic acid
3 Vitamin B6,pyridoxine
3 Caffeic acid
3 Exercise
3 Celastrol
3 Coenzyme Q10
3 Cysteamine
3 diet Short Term Fasting
3 Methylene blue
3 Magnolol
3 Melatonin
3 nicotinamide adenine dinucleotide
3 Rutin
3 Selenite (Sodium)
3 Ursolic acid
2 Baicalin
2 beta-carotene(VitA)
2 borneol
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Chlorophyllin
2 Calorie Restriction Mimetics
2 Spermidine
2 Metformin
2 Ellagic acid
2 Emodin
2 Ginkgo biloba
2 EMF
2 Naringin
2 Phosphatidylserine
2 Chemotherapy
2 Vitamin D3
2 Vitamin K2
1 Astragalus
1 alpha Linolenic acid
1 Aluminum
1 doxorubicin
1 Butyrate
1 Paclitaxel
1 chitosan
1 Choline
1 Cinnamon
1 Selenium
1 Hydroxycinnamic-acid
1 Aspirin -acetylsalicylic acid
1 Silver-NanoParticles
1 Dichloroacetate
1 Bortezomib
1 diet Methionine-Restricted Diet
1 diet FMD Fasting Mimicking Diet
1 MCToil
1 Methylsulfonylmethane
1 Psoralidin
1 Salvia officinalis
1 Aromatherapy
1 Sesame seeds and Oil
1 Anti-oxidants
1 Aflavin-3,3′-digallate
1 Vitamin A, Retinoic Acid
1 Vitamin B1/Thiamine
1 Vitamin B3,Niacin
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1105  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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