selectivity Cancer Research Results

selectivity, selectivity: Click to Expand ⟱
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The selectivity of cancer products (such as chemotherapeutic agents, targeted therapies, immunotherapies, and novel cancer drugs) refers to their ability to affect cancer cells preferentially over normal, healthy cells. High selectivity is important because it can lead to better patient outcomes by reducing side effects and minimizing damage to normal tissues.

Achieving high selectivity in cancer treatment is crucial for improving patient outcomes. It relies on pinpointing molecular differences between cancerous and normal cells, designing drugs or delivery systems that exploit these differences, and overcoming intrinsic challenges like tumor heterogeneity and resistance

Factors that affect selectivity:
1. Ability of Cancer cells to preferentially absorb a product/drug
-EPR-enhanced permeability and retention of cancer cells
-nanoparticle formations/carriers may target cancer cells over normal cells
-Liposomal formations. Also negatively/positively charged affects absorbtion

2. Product/drug effect may be different for normal vs cancer cells
- hypoxia
- transition metal content levels (iron/copper) change probability of fenton reaction.
- pH levels
- antiOxidant levels and defense levels

3. Bio-availability
Scientific Papers found: Click to Expand⟱
7626- HPT,  Rad,    Dynamics of chromosomal aberrations, induction of apoptosis, BRCA2 degradation and sensitization to radiation by hyperthermia
- in-vitro, Var, NA
BRCA2↓, selectivity↑, RadioS↑, eff↝,
7542- HT,    Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B - in-vitro, Nor, RWPE-1
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK2↓, CDK4↓, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, tumCV↓, Akt↓, STAT3↓, NF-kB↓, AR↓, ROS↑, mtDam↑, BioAv↓, toxicity↓, eff↑,
4637- HT,    Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells
- in-vitro, Nor, RWPE-1 - in-vitro, Pca, LNCaP - in-vitro, Pca, 22Rv1 - in-vitro, Pca, PC3
selectivity↑, TumCMig↓, p‑Akt↓, ROS↑, CSCs↓, CD44↓, TumCP↓,
4638- HT,    Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation
- in-vitro, CRC, DLD1 - NA, NA, 1-
selectivity↑, ROS↑, Akt↑, FOXO3↓, Apoptosis↑,
4639- HT,    Hydroxytyrosol Induces Apoptosis, Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, p‑Akt↓, p‑STAT3↓, NF-kB↓, AR↓, ROS↑, *BioAv↓, *toxicity∅,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
7568- HYP,  PacT,    Administration with hyperoside sensitizes breast cancer cells to paclitaxel by blocking the TLR4 signaling
- in-vitro, BC, MDA-MB-231
Inflam↓, AntiTum↑, selectivity↑, chemoP↑, TumCI↓, ChemoSen↑, tumCV↓, Apoptosis↑, Casp3↑, TLR4↓, NF-kB↓,
7553- HYP,    Hyperoside induces both autophagy and apoptosis in non-small cell lung cancer cells in vitro
- in-vitro, NSCLC, A549 - in-vitro, Nor, BEAS-2B
LC3II↑, selectivity↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, p‑4E-BP1↓, p‑ERK↑, tumCV↓, Apoptosis↑,
7596- I3C,    Selective responsiveness of human breast cancer cells to indole-3-carbinol, a chemopreventive agent
- in-vitro, BC, NA
TumCG↓, selectivity↑, P450↑,
7607- I3C,    Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line
- in-vitro, AML, THP1
AhR↑, TumCP↓, selectivity↑, Bcl-2↓, Fas↑, P21↑, p27/CDKN1B↑, P53↓, CDK2↓,
7610- I3C,    Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line
- in-vitro, BC, MDA-MB-468 - in-vitro, Nor, HBL-100 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
Akt↓, selectivity↑, Apoptosis↑,
7612- I3C,    Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells
- in-vitro, Nor, MCF10
selectivity↑, Bax:Bcl2↓, Bcl-xL↓, BAX↑, MMP↓, Cyt‑c↑, TumCD↑,
7585- I3C,    Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells
- in-vitro, BC, NA
Apoptosis↑, selectivity↑, Akt↓, NF-kB↓,
7801- IBC,    Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter
- in-vitro, CRC, HT-29
PSEN2/PS-2↓, AntiCan↑, Apoptosis↑, Akt↓, ERK↓, *antiOx↑, *Inflam↓, *neuroP↑, *toxicity↓, selectivity↑,
7807- IBC,    Isobavachalcone exerts anti‑proliferative and pro‑apoptotic effects on human liver cancer cells by targeting the ERKs/RSK2 signaling pathway
- in-vitro, Liver, HepG2 - in-vitro, Liver, Hep3B - in-vitro, Nor, L02
ERK↓, TumCP↓, selectivity↑,
7818- IBC,    Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma
- in-vitro, neuroblastoma, NA
TumCD↑, selectivity↑, Apoptosis↑, DNAdam↑, pro‑Casp3↑, pro‑Casp9↑, cl‑Casp3↑, cl‑Casp9↑, NA↑, BAX?,
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, Synergy↑,
7674- iod,    Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway
- in-vitro, BC, NA
AntiTum↑, selectivity↑, MMP↓, antiOx↑, Thiols↓, Bcl-2↓, BAX↑, eff↓, Casp↑, ROS↓, ROS↑, Cyt‑c↑, AIF↑,
7678- iod,    Signaling pathways involved in the antiproliferative effect of molecular iodine in normal and tumoral breast cells: evidence that 6-iodolactone mediates apoptotic effects
- in-vitro, Nor, MCF12A - in-vitro, BC, MCF7
TumCCA↑, selectivity↑, 6IL↑, eff↑,
7719- IP6,    Effect of inositol hexaphosphate (IP(6)) on human normal and leukaemic haematopoietic cells
- in-vitro, CML, NA
TumCD↑, TumCCA↑, selectivity↑, TumCP↓,
7690- IP6,  Ins,    Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application
- Review, Colon, NA
AntiCan↑, Imm↑, antiOx↑, TumCP↓, Diff↑, TumCG↓, Synergy↑, P21↓, p27/CDKN1B↓, pRB↓, TumCCA↑, PI3K↓, Akt↓, PKCδ↓, RAS↓, ERK↓, NF-kB↓, Inflam↓, MMP9↓, IronCh↑, NK cell↑, selectivity↑, ChemoSen↑, chemoP↑, toxicity↓, Remission↑,
7699- IP6,    IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise
- Review, Var, NA
*Iron∅, ChemoSen↑, *cardioP↑, neuroP↑, IronCh∅, P21↓, p27/CDKN1B↓, p‑pRB↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TumW↓, TumCI↓, TumMeta↓, Imm↑, Diff↑, selectivity↑, toxicity↓, RenoP↑, QoL↑,
7748- ISL,  GEM,    Isoliquiritigenin combined with gemcitabine inhibited lung cancer by suppressing JAK2/STAT3 signaling via lncRNA-p21/miRNA-4534 axis
- in-vitro, Lung, NA
Dose↝, Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, P21↑, selectivity↑, JAK2↓, STAT3↓,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
7787- ISL,    Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling
- in-vitro, BC, NA
β-catenin/ZEB1↓, ChemoSen↑, CSCs↓, ABCG2↓, Proteasome↓, GRP78/BiP↓, selectivity↑,
7732- isoFl,    Biological activities and therapeutic potential of soy isoflavones: a focus on anticancer activity
- Review, Var, NA
*Inflam↓, *ROS↓, Apoptosis↑, NOS2↑, *Aβ↓, *BioAv↓, *BioAv↑, *BioAv↝, *neuroP↑, *BBB↑, TNF-α↓, ROS↑, selectivity↑, ChemoSen↑, eff↝,
7856- isoO,    Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways
- in-vitro, Lung, A549
Bacteria↓, Inflam↓, TumCD↑, selectivity↑, Apoptosis↑, MMP↓, BAX↑, cl‑Casp3↑, PARP↓, Bcl-2↓, TumCCA↑, CycB/CCNB1↓, CDK1↓, CDK2↓, NA↑, p27/CDKN1B↑, ROS↑, eff↓, p‑p38↑, p‑JNK↑, ERK↓, STAT3↓, NF-kB↓,
7854- isoO,    Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells
- in-vitro, Liver, HepG2
TumCD↑, selectivity↑, *toxicity↓, cl‑PARP↑, DNAdam↑, Bax:Bcl2↑, MMP↓, Cyt‑c↑, Casp3↑, ROS↑, NO↑, p‑Akt↓, FOXO4↑, eff↓,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
7810- ISQ,    Isoquercitrin Inhibits Lung Cancer Cell Growth Through Triggering Pyroptosis and Ferroptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B
tumCV↓, selectivity↑, Apoptosis↑, NLRP3↑, Pyro↑, Ferroptosis↑, ROS↑, eff↓, Dose↝, TumCG↓,
7795- ISQ,    The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway
- in-vitro, Melanoma, SK-MEL-28 - in-vitro, Nor, HaCaT
BioAv↑, TumCP↓, selectivity↑, DNAdam↑, Apoptosis↑, TumCCA↑, Bcl-2↓, cl‑PARP↑, BAX↑, AIF↑, Endoglin↑, PI3K↓, Akt↓, mTOR↓,
7792- ISQ,    Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/β-catenin signaling pathway
- in-vitro, CRC, SW48 - in-vitro, CRC, DLD1 - in-vitro, CRC, HCT116 - in-vitro, Nor, IEC-18
Wnt↓, TumCG↓, selectivity↑, β-catenin/ZEB1↓, TumCMig↓,
8034- IVM,  doxoR,    Synergistic potential of Ivermectin and doxorubicin in oral squamous cell carcinoma: an in vitro investigation
- in-vitro, Oral, NA
tumCV↓, selectivity↑, TumCCA↑, Apoptosis↓, BAX↑, Casp3↑, P53↑, Bcl-2↓, Ki-67↓, IL6↓, ROS↑, mtDam↑,
8033- IVM,  dietMet,  rMETase,    Direct comparison of efficacy of combining ivermectin versus five first-line chemotherapy drugs with recombinant methioninase against colon-cancer cells
- in-vitro, CRC, HCT116
eff↑, ChemoSen↑, Synergy↑, selectivity↑, Synergy↑, TumCCA↑,
8022- IVM,    Antibiotic ivermectin preferentially targets renal cancer through inducing mitochondrial dysfunction and oxidative damage
- vitro+vivo, RCC, NA
AntiP↑, TumCP↓, Apoptosis↑, selectivity↑, TumCG↓, MMP↓, mitResp↓, ATP↓, ROS↑, eff↓,
8021- IVM,    The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells
- vitro+vivo, AML, HL-60 - NA, lymphoma, U937 - NA, Pca, DU145
AntiP↑, TumCD↑, selectivity↑, TumCG↓, i-Chl↑, ROS↑, ChemoSen↑,
8020- IVM,    Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer
- vitro+vivo, BC, NA
AntiP↑, TumAuto↑, Akt↓, mTOR↓, PAK1↓, selectivity↑,
8046- IVM,    Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress
- in-vitro, CML, NA
TumCD↑, mtDam↑, ROS↓, selectivity↑, compI↓, mitResp↓, eff↓,
8051- IVM,  Cisplatin,  rMETase,    Selective Synergy of the Combination of Recombinant Methioninase With Cisplatinum and Ivermectin Which Eradicates Lung-Cancer Cells but Has No Synergy and Limited Effect on Normal Fibroblasts
- in-vitro, Lung, A549
Dose↝, ChemoSen↑, selectivity↑,
8052- IVM,  rMETase,    Selective Synergy of Ivermectin Combined With Recombinant Methioninase Against Colon-Cancer Cells in Contrast to Normal Fibroblasts
- in-vitro, CRC, HCT116 - in-vitro, Nor, Hs27
Dose↝, TumCP↓, selectivity↑,
7892- IVT,    Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway
- in-vitro, Nor, HCEC 1CT - in-vivo, Colon, NA
TumCP↓, selectivity↑, TumCMig↓, TumCI↓, EMT↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Bcl-2↓, BAX↑, Casp3↑, TumVol↓, TumW↓,
8002- JG,    Identification and Biological Evaluation of Juglone-Derived STAT3 Inhibitors against Colorectal Cancer
- in-vitro, PC, NA - in-vitro, CRC, NA
eff↑, STAT3↓, TumCP↓, selectivity↑,
1917- JG,    Inhibition of human leukemia cells growth by juglone is mediated via autophagy induction, endogenous ROS production, and inhibition of cell migration and invasion
- in-vitro, AML, HL-60
selectivity↑, LC3I↑, LC3II↑, Beclin-1/ATG6↑, ROS↑, tumCV↓, Dose↝, TumAuto↑,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8095- KAE,    Kaempferol: A Key Emphasis to Its Anticancer Potential
- Review, Var, NA
*AntiBio↑, *Inflam↓, *AntiTum↓, *antiOx↑, *cardioP↑, *neuroP↑, *AntiDiabetic↑, Risk↓, TumCCA↑, EMT↓, PI3K↓, Akt↓, MMP2↓, Casp3↑, Casp7↑, Casp9↑, PARP↑, *ROS↓, angioG↓, *BioAv↑, BioAv↑, selectivity↑, GLUT1↓, MCT1↓, ROS↓, ROS↑, Trx↓, Cyt‑c↑, MMP↓, miR-21↓, SOCS-3↓, STAT3↓, CDK1↓, CycB/CCNB1↑, HIF-1↓, JAK1↑, PTEN↑,
8102- KAE,    Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study
- vitro+vivo, GC, MKN-28 - vitro+vivo, GC, SGC-7901 - in-vitro, GC, GES-1
TumCP↓, TumCCA↑, Apoptosis↑, selectivity↑, TumVol↓, CycB/CCNB1↓, CDK1↓, CDC25↓, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, p‑Akt↓, p‑ERK↓, COX2/PTGS2↓,
8063- KAE,    Kaempferol exerts anti-proliferative effects on human ovarian cancer cells by inducing apoptosis, G0/G1 cell cycle arrest and modulation of MEK/ERK and STAT3 pathways
- in-vitro, Ovarian, NA
Dose↓, selectivity↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, TumCCA↑, MEK↓, ERK↓, STAT3↓,
8065- KAE,    Kaempferol, a new nutrition-derived pan-inhibitor of human histone deacetylases
- in-vitro, Liver, HepG2 - in-vitro, CRC, HCT116
HDAC↓, tumCV↓, TumCP↓, selectivity↑, ac‑H3↝,
8066- KAE,  Rad,    Radiosensitization of non-small cell lung cancer by kaempferol
- in-vivo, Lung, A549
TumCG↓, selectivity↑, TumCCA↑, RadioS↑,
8072- KAE,    Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation
- Review, CRC, NA
AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, Synergy↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,

Showing Research Papers: 351 to 400 of 677
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 677

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 3,   NA⇅, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 16,   antiOx⇅, 1,   Catalase↓, 8,   Catalase↑, 3,   ENOX2↓, 2,   Fenton↑, 8,   frataxin↑, 1,   GCLC↑, 1,   GPx↓, 2,   GPx↑, 2,   GPx4↓, 6,   GSH?, 1,   GSH↓, 45,   GSH↑, 5,   i-GSH∅, 1,   GSH/GSSG↓, 8,   GSSG↑, 3,   GSTs↝, 1,   H2O2↓, 2,   H2O2↑, 14,   mt-H2O2↑, 1,   HO-1↓, 3,   HO-1↑, 10,   HO-2↓, 1,   Iron↓, 4,   Iron↑, 4,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 2,   Keap1↝, 1,   lipid-P↓, 2,   lipid-P↑, 20,   lipidDe↓, 1,   MDA↓, 3,   MDA↑, 7,   i-MDA↑, 1,   NADH↓, 3,   NADH↑, 1,   mt-NADH↓, 1,   NADHdeh?, 1,   NOX↓, 2,   NOX↑, 1,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 11,   NRF2↑, 13,   NRF2∅, 1,   p‑NRF2↑, 1,   Prx↓, 1,   Prx3↑, 1,   Prx4↓, 1,   Prx4↑, 1,   PrxI↓, 1,   RNS↑, 3,   ROS?, 4,   ROS↓, 22,   ROS↑, 311,   ROS⇅, 10,   ROS↝, 3,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 4,   mt-ROS↑, 22,   RPM↑, 1,   SOD↓, 5,   SOD↑, 5,   SOD2↓, 3,   SOD2↑, 1,   Thiols↓, 3,   Trx↓, 4,   Trx↑, 1,   TrxR↓, 9,   TrxR1↓, 2,   mt-TrxR1↓, 1,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   IronCh∅, 1,   STEAP3↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   p‑CDC2↓, 1,   CDC25↓, 5,   CDC25↑, 1,   compI↓, 7,   compII↓, 1,   compIII↓, 2,   compIII↑, 1,   compIV↓, 1,   compV↓, 1,   EGF↓, 2,   ETC↓, 10,   ETC↝, 1,   HSP60/HSPD1↑, 1,   Insulin↓, 3,   mitResp↓, 8,   mitResp↑, 1,   mtDam↑, 38,   OCR↓, 9,   OCR↑, 5,   OXPHOS↓, 9,   OXPHOS↑, 5,   mt-OXPHOS↓, 2,   mt-OXPHOS↑, 2,   PDH↑, 1,   p‑PDH↓, 2,   p‑PDH↑, 1,   PGC-1α↑, 2,   PINK1↑, 1,   SDH↓, 1,   SIRT3↓, 1,   SIRT3↑, 4,   mt-TrxR2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   p‑ACC↑, 1,   ACLY↓, 1,   ALAT↓, 2,   AminoA↓, 1,   AMP↑, 1,   AMPK↑, 12,   p‑AMPK↑, 3,   ANXA7↑, 2,   ATP↓, 27,   ATP∅, 1,   ATP:AMP↓, 1,   cAMP↓, 1,   ECAR↓, 7,   ECAR↝, 1,   ECAR∅, 1,   FABP4↓, 1,   FAO↓, 1,   FAO↑, 1,   FASN↓, 1,   GAPDH↓, 2,   glucose↝, 1,   GlucoseCon↓, 16,   GlucoseCon∅, 1,   Glycolysis↓, 34,   Glycolysis∅, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 1,   H2S↑, 1,   Histones↝, 1,   HK2?, 1,   HK2↓, 11,   HK2∅, 1,   HMG-CoA↓, 5,   IDO1↓, 2,   KeyT↑, 1,   lactateProd↓, 21,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 5,   LDHA∅, 1,   LDL↓, 2,   lipidLev↓, 1,   lipoGen↓, 2,   MCT4↓, 1,   NAD↓, 2,   NADPH↓, 4,   NADPH↑, 2,   OAA↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 8,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 6,   PDKs↑, 1,   PFK↓, 2,   PFK1↓, 2,   PFKP↓, 1,   PKM1↑, 1,   PKM2↓, 9,   polyA↓, 1,   PPP↑, 1,   Pyruv↓, 1,   SCD1↓, 4,   SIRT1↓, 4,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,   TCA?, 1,   TCA↓, 1,   TS↓, 2,   Warburg↓, 9,  

Cell Death(tgid=5) ⓘ

AIF↑, 17,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 11,   Apoptosis↑, 256,   Apoptosis∅, 1,   mt-Apoptosis↑, 4,   aSmase↑, 1,   BAD↓, 2,   BAD↑, 9,   Bak↑, 6,   BAX?, 1,   BAX↓, 2,   BAX↑, 87,   BAX⇅, 2,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 25,   Bcl-2?, 1,   Bcl-2↓, 95,   Bcl-2↑, 1,   Bcl-xL↓, 20,   BID↑, 4,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↑, 2,   BNIP3?, 1,   Casp↓, 2,   Casp↑, 37,   Casp↝, 1,   Casp1↑, 2,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp3?, 1,   Casp3↓, 4,   Casp3↑, 120,   cl‑Casp3↑, 25,   proCasp3↓, 1,   pro‑Casp3↓, 1,   pro‑Casp3↑, 1,   CASP4↑, 1,   Casp6↓, 1,   Casp6↑, 2,   Casp7↑, 21,   cl‑Casp7↑, 2,   Casp8↓, 2,   Casp8↑, 38,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 76,   cl‑Casp9↑, 5,   pro‑Casp9↑, 1,   cFLIP↓, 2,   Cupro↑, 2,   Cyt‑c↓, 2,   Cyt‑c↑, 84,   Cyt‑c↝, 1,   Diablo↑, 4,   DR5↑, 13,   Endon↑, 2,   FADD↑, 2,   Fap1↓, 1,   Fas↓, 1,   Fas↑, 14,   FasL↑, 8,   Ferroptosis↑, 13,   GSDMC↑, 1,   GSDMD↑, 1,   IAP1↓, 2,   IAP1↑, 1,   IAP2/BIRC3↓, 2,   IAP2/BIRC3↑, 1,   ICAD↑, 1,   iNOS↓, 4,   Mcl-1↓, 10,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 6,   MDM2↑, 2,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↓, 2,   MOMP↑, 3,   Necroptosis↑, 3,   necrosis↑, 5,   NOXA↑, 2,   p38↓, 2,   p38↑, 8,   p‑p38↓, 1,   p‑p38↑, 6,   Paraptosis↑, 5,   PUMA↑, 5,   Pyro↑, 5,   RIP1↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   SK↓, 1,   survivin↓, 26,   TNFR 1↑, 1,   TRAIL↑, 5,   TumCD↓, 2,   TumCD↑, 50,   TUNEL↑, 1,   XIAP↓, 13,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 75,   Akt↑, 4,   p‑Akt↓, 28,   p‑Akt↑, 1,   AKT1↓, 3,   AMPKα↑, 1,   CaMKII ↓, 1,   Cavin3↓, 1,   CIP2A↓, 1,   cSrc↓, 1,   EF-1α↓, 1,   EGFR↓, 14,   p‑EGFR↓, 1,   ERK↓, 25,   ERK↑, 4,   p‑ERK↓, 10,   p‑ERK↑, 3,   HER2/EBBR2↓, 2,   Hippo↑, 1,   IGF-1R↓, 1,   p‑IGF-1R↓, 1,   IKKα↓, 3,   IKKα↑, 1,   IκB↓, 1,   IκB↑, 1,   JAK↓, 3,   JAK1↓, 2,   JAK1↑, 1,   JAK2↓, 7,   JNK↓, 6,   JNK↑, 16,   p‑JNK↑, 7,   MAPK↓, 17,   MAPK↑, 8,   p‑MAPK↑, 2,   MARK4↓, 2,   MEK↓, 4,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 36,   mTOR↑, 1,   mTOR⇅, 1,   p‑mTOR↓, 7,   mTORC2↑, 1,   p70S6↓, 1,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PI3K↓, 47,   PI3K↑, 2,   p‑PI3K↓, 7,   PI3K/Akt↓, 1,   PIAS-3↑, 1,   PKA↓, 2,   PKCδ↓, 4,   PKCδ↑, 2,   PTEN↑, 12,   Raf↓, 3,   c-Raf↓, 1,   RAS↓, 4,   p‑S6K↓, 2,   SHP1↑, 1,   Sp1/3/4↓, 8,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 34,   STAT3↑, 1,   p‑STAT3↓, 6,   p‑STAT3↑, 2,   mt-STAT3↓, 1,   STAT4↓, 1,   STAT6↓, 2,   p‑STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 1,   ATF4↑, 6,   ATF4↝, 1,   BRD4↓, 1,   ChrMod↑, 2,   cJun↑, 3,   cMyc↓, 17,   cMyc↑, 1,   DNMT1↓, 6,   DNMT1↑, 1,   DNMTs↓, 5,   EZH2↓, 4,   FOXO↑, 2,   FOXO3↓, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↑, 2,   GATA3↓, 1,   H3↑, 2,   ac‑H3↑, 4,   ac‑H3↝, 1,   H4↑, 1,   ac‑H4↓, 1,   ac‑H4↑, 4,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 22,   HDAC1↓, 4,   HDAC2↓, 2,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC8↓, 1,   miR-124-3p↓, 1,   miR-148a↑, 1,   miR-203↑, 1,   miR-21↓, 2,   miR-34a↑, 1,   miR-375↑, 1,   Myc↓, 1,   n-MYC↓, 1,   OCT4↓, 3,   other?, 1,   other↓, 2,   other↑, 15,   other⇅, 1,   other↝, 22,   other∅, 1,   PhotoS↑, 1,   PRMT6↓, 1,   SETBP1↓, 1,   SOX2↓, 2,   SOX4↓, 1,   SOX4↑, 1,   SUV39H↓, 1,   SUZ12↓, 1,   tumCV?, 1,   tumCV↓, 111,   tumCV↑, 4,   UTF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 21,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 2,   p‑eIF2α↓, 1,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 40,   ERStress↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 9,   HSP27↑, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 3,   HSP90↓, 7,   IRE1↑, 3,   PERK↓, 1,   PERK↑, 7,   p‑PERK↑, 1,   Proteasome?, 1,   Proteasome↓, 1,   UPR↑, 8,   XBP-1↓, 1,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 6,   ATG7↑, 3,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 6,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 2,   LC3B-II↓, 1,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↑, 9,   LC3s↓, 1,   lysoMP↑, 1,   MitoP↑, 1,   p62↓, 5,   p62↑, 6,   p‑p62↑, 1,   PARK2↑, 1,   SESN2↑, 1,   TumAuto?, 1,   TumAuto↓, 1,   TumAuto↑, 30,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↓, 1,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DNA-PK↑, 2,   DNAdam↓, 1,   DNAdam↑, 85,   DNArepair↓, 2,   DNArepair↑, 1,   FEN1↓, 1,   G9a↓, 1,   hTERT/TERT↓, 5,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   p16↑, 1,   P53↓, 2,   P53↑, 70,   P53↝, 3,   p‑P53↑, 3,   p53 Wildtype↓, 1,   p53 Wildtype↑, 1,   PARP↓, 9,   PARP↑, 13,   PARP↝, 1,   p‑PARP↑, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 58,   PARP1↑, 2,   cl‑PARP1↑, 2,   PCNA↓, 15,   PCNA↑, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 8,   TOP1↓, 4,   TOP1↝, 1,   TOP2↓, 2,   TOP2↑, 2,   TP53↑, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↑, 9,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   BRD4↓, 1,   CC(CDKs/cyclins)↓, 1,   CC(CDKs/cyclins)↑, 1,   CDK1↓, 7,   CDK1↑, 1,   CDK2↓, 29,   CDK2↑, 1,   CDK4↓, 33,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK6↓, 9,   CDK6↑, 3,   CDK8↓, 1,   CDKN1C/p57↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 5,   CycB/CCNB1↓, 15,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 48,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 16,   cycE1↓, 2,   cycF↑, 1,   E2Fs↓, 2,   FBXO5/EMI1↓, 1,   GADD34↑, 1,   GADD45A↑, 2,   Ki-67↓, 14,   P21?, 1,   P21↓, 5,   P21↑, 48,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 21,   PLK1↓, 1,   pRB↓, 1,   pRB↑, 1,   p‑pRB↓, 2,   p‑RB1↓, 4,   TubPol↓, 1,   TumCCA?, 3,   TumCCA↓, 4,   TumCCA↑, 178,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 3,   ALDH1A1↓, 2,   ALDH1A3↓, 1,   BMI1↓, 1,   CD133↓, 3,   CD24↓, 4,   cFos↓, 1,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 36,   CSCs↑, 1,   Diff↓, 3,   Diff↑, 7,   EP4/PTGER4↓, 1,   HH↓, 2,   HH↝, 1,   HMGCR↓, 1,   HMGCR↑, 1,   IGF-1↓, 3,   IGFBP3↑, 1,   Ki-67↓, 14,   mTORC1↓, 1,   p‑mTORC1↓, 1,   Nanog↓, 2,   Nestin↓, 2,   NOTCH↓, 6,   NOTCH↝, 1,   NOTCH1↓, 5,   NOTCH3↓, 2,   p300↓, 1,   SCF↓, 1,   Shh↓, 2,   STAT1↓, 1,   TOPflash↓, 1,   TumCG?, 1,   TumCG↓, 121,   TumCG↑, 4,   TumCG∅, 2,   TumCP?, 1,   TumCP↓, 140,   TumCP↑, 2,   Wnt↓, 21,   Wnt↝, 1,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 7,   ATPase↓, 1,   CA↓, 1,   Ca+2↓, 7,   Ca+2↑, 34,   Ca+2↝, 4,   i-Ca+2?, 1,   i-Ca+2↑, 2,   cal2↑, 1,   Cav1↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   i-Chl↑, 1,   Cofilin↓, 1,   p‑Cofilin↑, 1,   CTNNB1↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 20,   EMT↓, 37,   EpCAM↓, 1,   F-actin↓, 2,   FAK↓, 5,   FAK↑, 1,   FAK↝, 1,   p‑FAK↓, 2,   fascin↓, 1,   Fibronectin↓, 2,   FOSB↑, 1,   ITGB1↓, 2,   ITGB3↓, 1,   ITGB6↓, 1,   KRAS↓, 1,   MALAT1↓, 2,   MMP1↓, 1,   MMP2↓, 45,   MMP2↑, 1,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 45,   MMPs↓, 11,   MUC4↓, 1,   N-cadherin?, 1,   N-cadherin↓, 10,   N-cadherin↑, 1,   PAK1↓, 2,   PDGF↓, 4,   Rac1↓, 2,   RECK↑, 2,   Rho↓, 3,   ROCK1↓, 1,   Slug↓, 4,   Smad1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   Snail↓, 9,   TET1↑, 1,   TG2/TGase↓, 1,   TGF-β↓, 6,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↑, 6,   TIMP3↑, 1,   TSC1↑, 1,   TumCA↑, 1,   TumCI↓, 58,   TumCMig↓, 67,   TumMeta↓, 43,   TumMeta↑, 1,   Twist↓, 12,   uPA↓, 7,   Vim↓, 10,   Zeb1↓, 7,   ZEB2↓, 1,   α-tubulin↓, 2,   β-catenin/ZEB1↓, 23,   β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 55,   angioG↑, 3,   CD31/PECAM-1↓, 1,   CD31/PECAM-1↑, 1,   EGR1↑, 1,   Endoglin↑, 2,   HIF-1↓, 5,   Hif1a↓, 31,   Hif1a↑, 2,   HIF2a↓, 1,   Hypoxia↓, 1,   LOX1↓, 1,   NO↓, 2,   NO↑, 7,   PHDs↓, 1,   VCAM-1↓, 1,   VEGF↓, 43,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 9,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 2,   CellMemb↑, 2,   CLDN1↓, 1,   CTR1↑, 1,   EPR↑, 9,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT2↓, 2,   GLUT4↓, 1,   MMP?, 2,   MMP↓, 152,   MMP↝, 1,   MPT↓, 1,   MPT↑, 9,   NHE1↓, 2,   sonoP↑, 1,   SVCT-2↓, 1,   TRPC1↑, 1,   TRPM7↓, 1,   TRPV1↓, 1,   TRPV1↑, 4,   TRPV2↑, 1,   VGCC↑, 1,   VGSC↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CCR7↓, 1,   CD4+↑, 1,   CD44↓, 10,   CD47↓, 1,   CD8+↑, 4,   cDC2↓, 1,   p‑cDC2↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 32,   COX2/PTGS2↑, 4,   CXCc↓, 1,   CXCR4↓, 3,   DCells↑, 2,   DR4↑, 3,   DR6↑, 1,   FOXP3↓, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   Igs↑, 1,   IL1↓, 2,   IL1↑, 1,   IL10↓, 1,   IL10↑, 1,   IL1β↓, 7,   IL1β↑, 3,   IL2↑, 1,   IL6↓, 15,   IL8↓, 4,   IL8↑, 1,   Imm↑, 9,   Imm↝, 1,   INF-γ↑, 1,   Inflam↓, 28,   LIF↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MCT1↓, 1,   NF-kB↓, 71,   NF-kB↑, 9,   p‑NF-kB↑, 2,   NK cell↑, 8,   NLRP3↓, 1,   NLRP3↑, 3,   p50↓, 1,   p65↓, 3,   p‑p65↓, 1,   PD-L1↓, 3,   PGE2↓, 8,   PSA↓, 5,   RAGE↓, 1,   SOCS-3↓, 1,   SOCS-3↑, 1,   T-Cell↑, 2,   Th1 response↑, 1,   Th2↑, 1,   TLR4↓, 3,   TNF-α↓, 17,   TNF-α↑, 6,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   pH↝, 2,   e-pH↑, 1,   i-pH↓, 1,   i-pH↑, 2,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AhR↑, 1,   AR↓, 9,   CYP24A1↓, 1,   ER-α36↓, 2,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↓, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 6,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 31,   BioAv↑, 33,   BioAv↝, 5,   BioEnh↑, 1,   chemoR↓, 2,   ChemoSen↓, 1,   ChemoSen↑, 153,   ChemoSen∅, 3,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 8,   Dose↓, 10,   Dose↑, 15,   Dose⇅, 1,   Dose↝, 81,   Dose∅, 18,   eff?, 1,   eff↓, 87,   eff↑, 140,   eff↝, 22,   GSTP1/GSTπ↓, 1,   GSTZ1↓, 1,   Half-Life?, 1,   Half-Life↓, 6,   Half-Life↑, 4,   Half-Life↝, 11,   Half-Life∅, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 10,   P-gp/ABCB1∅, 1,   P450↓, 1,   P450↑, 1,   P450↝, 1,   RadioS↓, 1,   RadioS↑, 64,   selectivity?, 9,   selectivity↓, 10,   selectivity↑, 676,   selectivity↝, 2,   selectivity∅, 4,   Synergy↑, 91,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 9,   AST↓, 1,   B2M↓, 1,   BG↓, 4,   BloodF↑, 1,   BMD↑, 1,   BRCA1↓, 1,   p‑BRCA1↑, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 14,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↓, 1,   EZH2↓, 4,   Ferritin↓, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 5,   IL6↓, 15,   KeyT↑, 1,   KRAS↓, 1,   LDH?, 1,   LDH↓, 5,   LDH↑, 6,   Maspin↑, 1,   Myc↓, 1,   NOS2↓, 2,   NOS2↑, 1,   PD-L1↓, 3,   PSA↓, 5,   RAGE↓, 1,   SUZ12↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 55,   AntiCan∅, 1,   antiCG↓, 1,   AntiDiabetic↑, 1,   antiNeop↑, 1,   antiNeop∅, 1,   AntiTum↓, 1,   AntiTum↑, 24,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 6,   CardioT↓, 1,   chemoP↑, 29,   chemoPv↑, 21,   ChemoSideEff↓, 3,   fatigue↓, 1,   hepatoP↑, 10,   hepatoP∅, 1,   neuroP↑, 8,   NP/CIPN↓, 1,   OS↑, 30,   OS⇅, 1,   OS∅, 1,   Pain↓, 4,   PDE4↓, 1,   PFS↑, 1,   QoL↑, 9,   radioP↑, 16,   Remission↑, 2,   RenoP↑, 4,   Risk↓, 13,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 28,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 13,   toxicity∅, 5,   TumVol↓, 36,   TumW↓, 17,   Weight↑, 4,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 4,   Bacteria↓, 5,   GutMicro↑, 3,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 5,  
Total Targets: 956

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 2,   antiOx↑, 68,   mt-antiOx↑, 1,   ARE↑, 1,   Catalase↑, 21,   Copper↓, 1,   Fenton↓, 2,   GPx↑, 18,   GPx1↑, 1,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 18,   GSH/GSSG↑, 1,   GSR↑, 2,   GSSG↓, 1,   GSSG∅, 1,   GSTs↑, 7,   H2O2↓, 1,   H2O2↑, 1,   HDL↓, 1,   HDL↑, 3,   HO-1↑, 13,   hyperG↓, 1,   Iron↓, 2,   Iron↑, 1,   Iron∅, 1,   lipid-P↓, 15,   MDA↓, 12,   MPO↓, 2,   NOX↓, 1,   NOX4↓, 1,   Nrf1↑, 1,   NRF2↑, 21,   Prx↑, 1,   Prx4∅, 1,   RNS↓, 3,   ROS?, 2,   ROS↓, 64,   ROS↑, 4,   ROS∅, 18,   SAM-e↑, 1,   selenoP↑, 2,   SOD?, 1,   SOD↓, 1,   SOD↑, 23,   SOD1↑, 3,   SOD2↑, 2,   TAC↑, 1,   TBARS↓, 2,   VitC↑, 2,   VitE↓, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   EGF↓, 1,   mitResp↑, 1,   OCR↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACLY∅, 1,   ALAT↓, 4,   AMPK↑, 1,   ATP↑, 4,   ATP↝, 1,   ECAR↓, 1,   GlucoseCon↑, 2,   Glycolysis↓, 2,   Glycolysis↑, 1,   GSK‐3β↓, 2,   HK2↓, 1,   HMG-CoA↓, 1,   lactateProd↓, 1,   LDL↓, 4,   lipidLev↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 1,   NADPH∅, 1,   PFK↓, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 3,   Casp3∅, 1,   cl‑Casp8↑, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   Ferroptosis↓, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 5,   p38↓, 1,   survivin↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↓, 1,   ERK↓, 1,   ERK↑, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   JAK2↑, 1,   JNK↓, 1,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 1,   mTOR↓, 4,   PI3K↑, 2,   PKCδ?, 1,   PTEN↑, 1,   STAT↓, 1,   STAT3↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   other↓, 2,   other↑, 2,   other↝, 7,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   p‑PERK↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 10,   DNAdam↑, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cellSen↑, 1,   GADD45A↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   Diff↑, 1,   EP2↓, 1,   FGF↑, 1,   neuroG↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 4,   Ca+2↑, 1,   Ca+2↝, 2,   Ca+2∅, 1,   i-Ca+2↓, 1,   MMP13↓, 1,   MMP9↓, 1,   MMPs↑, 1,   PDGF↑, 1,   serineP↓, 1,   TGF-β↑, 2,   TIMP1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   α-tubulin↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   HIF-1↓, 1,   Hif1a↓, 1,   Hif1a↑, 2,   NO↓, 4,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 6,   GastroP↑, 1,   GLUT1↓, 1,   IBI↑, 1,   MMP↑, 2,   MMP∅, 2,   SVCT-2↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   COX2/PTGS2↓, 10,   FOXP3↑, 1,   HMGB1↓, 1,   IFN-γ↓, 3,   IL1↑, 1,   IL10↓, 1,   IL10↑, 2,   IL17↓, 2,   IL1β↓, 9,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 8,   IL8↓, 1,   Imm↑, 7,   Inflam↓, 61,   LPS↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 3,   NF-kB↓, 14,   NLRP3↓, 2,   NLRP3↑, 1,   PGE2↓, 2,   PSA∅, 1,   TLR4↓, 1,   TNF-α↓, 11,   TNF-α↑, 1,   Treg lymp↝, 1,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 3,   AChE↑, 1,   BDNF↑, 5,   MAOA↓, 2,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 7,   BACE/β-secretase↓, 1,   tau↓, 2,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 3,   PPARγ↑, 1,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 19,   BioAv↑, 21,   BioAv↝, 5,   BioEnh↑, 1,   CompStab↑, 2,   CompStab↝, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 13,   eff↑, 9,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 3,   Half-Life∅, 2,   P450↓, 1,   selectivity↑, 13,   selectivity⇅, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALP↓, 2,   AST↓, 4,   BG↓, 1,   BMD↑, 2,   BP↓, 4,   Calcium↑, 1,   creat↓, 2,   CRP↓, 3,   HbA1c↓, 1,   HOMA↓, 1,   hs-CRP↓, 2,   IL6↓, 8,   LDH↓, 1,   Mag↑, 1,   PSA∅, 1,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 2,   Urea↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 5,   antiAll↑, 7,   AntiArt↑, 2,   AntiCan↓, 1,   AntiCan↑, 9,   AntiDiabetic↑, 10,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 1,   cardioP↑, 16,   CardioT↓, 1,   chemoP↑, 12,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↑, 5,   diuretic↑, 1,   hepatoP↑, 11,   memory↑, 8,   neuroP↑, 28,   Obesity↓, 4,   OS↑, 3,   Pain↓, 3,   radioP↑, 5,   RenoP↑, 3,   Risk↓, 2,   Stress↓, 1,   Stroke↓, 2,   toxicity?, 2,   toxicity↓, 53,   toxicity↝, 11,   toxicity∅, 19,   Weight↑, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiViral↑, 3,   Bacteria↓, 15,   GutMicro↑, 5,   Inf↓, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 2,  
Total Targets: 313

Scientific Paper Hit Count for: selectivity, selectivity
35 Silver-NanoParticles
30 Magnetic Fields
20 Radiotherapy/Radiation
17 Piperlongumine
14 Selenium NanoParticles
13 Thymoquinone
12 Chemotherapy
12 Betulinic acid
12 Dandelion Root
10 Vitamin C (Ascorbic Acid)
10 doxorubicin
10 chitosan
10 Sulforaphane (mainly Broccoli)
10 Dichloroacetate
10 salinomycin
10 Fisetin
10 Phenethyl isothiocyanate
10 Shikonin
9 Capsaicin
9 Propolis -bee glue
9 Cisplatin
9 Magnetic Field Rotating
8 Carvacrol
8 Copper and Cu NanoParticles
8 Hydrogen Gas
8 Honokiol
8 Ivermectin
8 Magnolol
8 Quercetin
8 Selenite (Sodium)
7 Artemisinin
7 Berberine
7 Curcumin
7 Kaempferol
6 3-bromopyruvate
6 Fenbendazole
6 Apigenin (mainly Parsley)
6 Ashwagandha(Withaferin A)
6 Melatonin
6 Baicalein
6 Chrysin
6 Lemongrass Extract/Citral
6 EGCG (Epigallocatechin Gallate)
6 Gallic acid
6 HydroxyTyrosol
6 Linalool
5 Rosmarinic acid
5 Metformin
5 Boron
5 Selenium
5 Ellagic acid
5 Hibiscus sabdariffa
5 Indole-3-carbinol
5 Licochalcone A
4 Alpha-Lipoic-Acid
4 Phenylbutyrate
4 Gold NanoParticles
4 α-Bisabolol / Chamomile oil
4 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
4 chaetocin
4 diet FMD Fasting Mimicking Diet
4 diet Methionine-Restricted Diet
4 Eurycomanone
4 Eugenol
4 Graviola
4 phytic acid, Inositol hexakisphosphate
4 Lactoferrin/Talactoferrin
4 Luteolin
4 Lutein
4 Lycopene
4 mebendazole
4 Methyl Jasmonate
4 Morin
4 Parthenolide
4 α-Santalol/Sandalwood oil
4 Terpinen-4-ol / Tea Tree Oil
4 VitK3,menadione
3 1,8-Cineole
3 chemodynamic therapy
3 Allicin (mainly Garlic)
3 Astaxanthin
3 Atorvastatin
3 Caffeic acid
3 Centella asiatica / Gotu kola → asiaticoside
3 Citric Acid
3 Coenzyme Q10
3 Cynaropicrin
3 Date Fruit Extract
3 Shilajit/Fulvic Acid
3 γ-linolenic acid (Borage Oil)
3 Helleborus niger extracts – Christmas Rose
3 Isobavachalcone
3 Isoliquiritigenin
3 isoorientin
3 isoquercitrin
3 Recombinant Methioninase
3 Nimbolide
3 Urolithin
2 Dipyridamole
2 Berbamine
2 Bifidobacterium
2 immunotherapy
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Crocetin
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Hydroxycinnamic-acid
2 Dihydrocaffeic Acid
2 Docosahexaenoic Acid
2 Oxygen, Hyperbaric
2 D-limonene
2 Disulfiram
2 Electrical Pulses
2 Evodiamine
2 Fucoidan
2 Gambogic Acid
2 Ginkgo biloba
2 Geldanamycin
2 Gossypol/AT-101
2 Hyperthermia
2 Hyperoside
2 Inositol
2 iodine
2 Juglone
2 Licorice
2 Methylene blue
2 methylseleninic acid
2 Methylglyoxal
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Marjoram (Origanum majorana)
2 SonoDynamic Therapy UltraSound
2 Plumbagin
2 Sulfasalazine
2 polyethylene glycol
2 Silymarin (Milk Thistle) silibinin
2 Aflavin-3,3′-digallate
2 Vitexin
2 Zerumbone
1 Auranofin
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Glucose
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Sorafenib (brand name Nexavar)
1 5-Aminolevulinic acid
1 Baicalin
1 Bufalin/Huachansu
1 probiotics
1 Brucea javanica
1 Brutieridin–Melitidin Mixture
1 Boswellia (frankincense)
1 Bullatacin
1 Butyrate
1 Carnosic acid
1 urea
1 Thymol-Thymus vulgaris
1 Cat’s Claw
1 Cannabidiol
1 Chocolate
1 Calorie Restriction Mimetics
1 Carvone
1 Polyphenols
1 Cucurbitacin
1 Cysteamine
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 Diclofenac
1 diet Ketogenic
1 Docetaxel
1 Dimethyl Sulfoxide
1 Mistletoe/Viscum album Extracts
1 Echinacea
1 Ginkgo biloba-EGb 761
1 5-fluorouracil
1 PXD, phenoxodiol
1 Emodin
1 Fennel Oil/Foeniculum vulgare
1 ferumoxytol
1 Formononetin
1 Flaxseed/Linseed
1 Flaxseed Oil
1 olaparib/LYNPARZA
1 Garcinol
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginkgetin
1 Ginseng
1 Grapeseed extract
1 High-Ozonide Oil
1 Paclitaxel/Taxol
1 Gemcitabine (Gemzar)
1 isoflavones
1 Isovitexin
1 Lactobacillus
1 lambertianic acid
1 low dose naltrexone
1 Photodynamic Therapy
1 Matrine
1 Mung Bean Sprouts
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Mushroom Chaga, Inonotus obliquus
1 Bicarbonate(Sodium)
1 Oleuropein
1 Propyl gallate
1 temozolomide
1 borneol
1 Psoralidin
1 Pterostilbene
1 Resveratrol
1 irinotecan
1 triptolide
1 Ursolic acid
1 Vitamin B1/Thiamine
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1110  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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