selectivity Cancer Research Results

selectivity, selectivity: Click to Expand ⟱
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The selectivity of cancer products (such as chemotherapeutic agents, targeted therapies, immunotherapies, and novel cancer drugs) refers to their ability to affect cancer cells preferentially over normal, healthy cells. High selectivity is important because it can lead to better patient outcomes by reducing side effects and minimizing damage to normal tissues.

Achieving high selectivity in cancer treatment is crucial for improving patient outcomes. It relies on pinpointing molecular differences between cancerous and normal cells, designing drugs or delivery systems that exploit these differences, and overcoming intrinsic challenges like tumor heterogeneity and resistance

Factors that affect selectivity:
1. Ability of Cancer cells to preferentially absorb a product/drug
-EPR-enhanced permeability and retention of cancer cells
-nanoparticle formations/carriers may target cancer cells over normal cells
-Liposomal formations. Also negatively/positively charged affects absorbtion

2. Product/drug effect may be different for normal vs cancer cells
- hypoxia
- transition metal content levels (iron/copper) change probability of fenton reaction.
- pH levels
- antiOxidant levels and defense levels

3. Bio-availability
Scientific Papers found: Click to Expand⟱
7610- I3C,    Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line
- in-vitro, BC, MDA-MB-468 - in-vitro, Nor, HBL-100 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
Akt↓, selectivity↑, Apoptosis↑,
7612- I3C,    Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells
- in-vitro, Nor, MCF10
selectivity↑, Bax:Bcl2↓, Bcl-xL↓, BAX↑, MMP↓, Cyt‑c↑, TumCD↑,
7585- I3C,    Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells
- in-vitro, BC, NA
Apoptosis↑, selectivity↑, Akt↓, NF-kB↓,
7801- IBC,    Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter
- in-vitro, CRC, HT-29
PSEN2/PS-2↓, AntiCan↑, Apoptosis↑, Akt↓, ERK↓, *antiOx↑, *Inflam↓, *neuroP↑, *toxicity↓, selectivity↑,
7807- IBC,    Isobavachalcone exerts anti‑proliferative and pro‑apoptotic effects on human liver cancer cells by targeting the ERKs/RSK2 signaling pathway
- in-vitro, Liver, HepG2 - in-vitro, Liver, Hep3B - in-vitro, Nor, L02
ERK↓, TumCP↓, selectivity↑,
7818- IBC,    Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma
- in-vitro, neuroblastoma, NA
TumCD↑, selectivity↑, Apoptosis↑, DNAdam↑, pro‑Casp3↑, pro‑Casp9↑, cl‑Casp3↑, cl‑Casp9↑, NA↑, BAX?,
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, eff↑,
7674- iod,    Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway
- in-vitro, BC, NA
AntiTum↑, selectivity↑, MMP↓, antiOx↑, Thiols↓, Bcl-2↓, BAX↑, eff↓, Casp↑, ROS↓, ROS↑, Cyt‑c↑, AIF↑,
7678- iod,    Signaling pathways involved in the antiproliferative effect of molecular iodine in normal and tumoral breast cells: evidence that 6-iodolactone mediates apoptotic effects
- in-vitro, Nor, MCF12A - in-vitro, BC, MCF7
TumCCA↑, selectivity↑, 6IL↑, eff↑,
7719- IP6,    Effect of inositol hexaphosphate (IP(6)) on human normal and leukaemic haematopoietic cells
- in-vitro, CML, NA
TumCD↑, TumCCA↑, selectivity↑, TumCP↓,
7690- IP6,  Ins,    Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application
- Review, Colon, NA
AntiCan↑, Imm↑, antiOx↑, TumCP↓, Diff↑, TumCG↓, eff↑, P21↓, p27/CDKN1B↓, pRB↓, TumCCA↑, PI3K↓, Akt↓, PKCδ↓, RAS↓, ERK↓, NF-kB↓, Inflam↓, MMP9↓, IronCh↑, NK cell↑, selectivity↑, ChemoSen↑, chemoP↑, toxicity↓, Remission↑,
7699- IP6,    IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise
- Review, Var, NA
*Iron∅, ChemoSen↑, *cardioP↑, neuroP↑, IronCh∅, P21↓, p27/CDKN1B↓, p‑pRB↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TumW↓, TumCI↓, TumMeta↓, Imm↑, Diff↑, selectivity↑, toxicity↓, RenoP↑, QoL↑,
7748- ISL,  GEM,    Isoliquiritigenin combined with gemcitabine inhibited lung cancer by suppressing JAK2/STAT3 signaling via lncRNA-p21/miRNA-4534 axis
- NA, Lung, NA
Dose↝, Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, P21↑, selectivity↑, JAK2↓, STAT3↓,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
7787- ISL,    Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling
- in-vitro, BC, NA
β-catenin/ZEB1↓, ChemoSen↑, CSCs↓, ABCG2↓, Proteasome↓, GRP78/BiP↓, selectivity↑,
7732- isoFl,    Biological activities and therapeutic potential of soy isoflavones: a focus on anticancer activity
*Inflam↓, *ROS↓, Apoptosis↑, NOS2↑, *Aβ↓, *BioAv↓, *BioAv↑, *BioAv↝, *neuroP↑, *BBB↑, TNF-α↓, ROS↑, selectivity↑, ChemoSen↑, eff↝,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
7854- isoO,    Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells
- in-vitro, Liver, HepG2
TumCD↑, selectivity↑, *toxicity↓, cl‑PARP↑, DNAdam↑, Bax:Bcl2↑, MMP↓, Cyt‑c↑, Casp3↑, ROS↑, NO↑, p‑Akt↓, FOXO4↑, eff↓,
7856- isoO,    Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways
- in-vitro, Lung, A549
Bacteria↓, Inflam↓, TumCD↑, selectivity↑, Apoptosis↑, MMP↓, BAX↑, cl‑Casp3↑, PARP↓, Bcl-2↓, TumCCA↑, CycB/CCNB1↓, CDK1↓, CDK2↓, NA↑, p27/CDKN1B↑, ROS↑, eff↓, p‑p38↑, p‑JNK↑, ERK↓, STAT3↓, NF-kB↓,
7795- ISQ,    The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway
- in-vitro, Melanoma, SK-MEL-28 - in-vitro, Nor, HaCaT
BioAv↑, TumCP↓, selectivity↑, DNAdam↑, Apoptosis↑, TumCCA↑, Bcl-2↓, cl‑PARP↑, BAX↑, AIF↑, Endoglin↑, PI3K↓, Akt↓, mTOR↓,
7810- ISQ,    Isoquercitrin Inhibits Lung Cancer Cell Growth Through Triggering Pyroptosis and Ferroptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B
tumCV↓, selectivity↑, Apoptosis↑, NLRP3↑, Pyro↑, Ferroptosis↑, ROS↑, eff↓, Dose↝, TumCG↓,
7792- ISQ,    Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/β-catenin signaling pathway
- in-vitro, CRC, SW48 - in-vitro, CRC, DLD1 - in-vitro, CRC, HCT116 - in-vitro, Nor, IEC-18
Wnt↓, TumCG↓, selectivity↑, β-catenin/ZEB1↓, TumCMig↓,
7892- IVT,    Isovitexin attenuates tumor growth in human colon cancer cells through the modulation of apoptosis and epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway
- in-vitro, Nor, HCEC 1CT - in-vivo, Colon, NA
TumCP↓, selectivity↑, TumCMig↓, TumCI↓, EMT↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Bcl-2↓, BAX↑, Casp3↑, TumVol↓, TumW↓,
1917- JG,    Inhibition of human leukemia cells growth by juglone is mediated via autophagy induction, endogenous ROS production, and inhibition of cell migration and invasion
- in-vitro, AML, HL-60
selectivity↑, LC3I↑, LC3II↑, Beclin-1↑, ROS↑, tumCV↓, Dose↝, TumAuto↑,
6464- LIN,  1,8-Cin,    Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells
- in-vitro, NSCLC, A549 - in-vitro, Nor, WI38
TumCP↓, TumCCA↑, selectivity↑, ROS↑, MMP↓, eff↓, TumCMig↓, eff↑,
6479- LIN,    Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer
- in-vivo, Colon, HCT116
Apoptosis↑, ROS↑, lipid-P↑, selectivity↑, TumCP↓, *toxicity↓,
2925- LT,    Luteolin Induces Carcinoma Cell Apoptosis through Binding Hsp90 to Suppress Constitutive Activation of STAT3
- in-vitro, Cerv, HeLa - in-vitro, Nor, HEK293 - in-vitro, BC, MCF7
HSP90↓, p‑STAT3↓, Apoptosis↑, selectivity↑,
2904- LT,    Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons
- in-vitro, Park, SK-N-SH - in-vitro, AD, NA
*ROS↓, *neuroP↑, *MMP↑, *Catalase↑, *GSH↑, selectivity↑, *eff↑, *Cyt‑c↓,
1715- Lyco,    Pro-oxidant Actions of Carotenoids in Triggering Apoptosis of Cancer Cells: A Review of Emerging Evidence
- Review, Var, NA
antiOx↑, ROS↑, ChemoSen↑, selectivity↑, eff↓, Casp3↑, Casp7↑, Casp9↑, P53↑, BAX↑, DNAdam↑, mtDam↑, eff↑,
4783- Lyco,    Lycopene suppresses gastric cancer cell growth without affecting normal gastric epithelial cells
- in-vitro, GC, AGS - in-vitro, GC, SGC-7901 - in-vitro, Nor, GES-1
TumCG↓, TumCCA↑, Apoptosis↑, MMP↓, selectivity↑, cycE1↓, TP53↑, *antiOx↑,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, eff↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, eff↑,
4796- Lyco,    The Anti-proliferation Effects of Lycopene on Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
TumCG↓, selectivity↑, *BioAv↑, *antiOx↑, *ROS↓, Risk↓, *cardioP↑,
2540- M-Blu,    Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
- Review, Var, NA - Review, AD, NA
*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
4534- MAG,    Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells
- in-vitro, Liver, HepG2 - in-vitro, CRC, COLO205
AntiCan↑, Apoptosis↑, selectivity↑, Ca+2↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,
4516- MAG,    Magnolol Induces Apoptosis and Suppresses Immune Evasion in Non-small Cell Lung Cancer Xenograft Models
- in-vivo, NSCLC, NA
selectivity↑, Apoptosis↑, TumCCA↑, Casp3↑, cycD1/CCND1↓, CDK4↓, VEGF↓, FOXP3↓, IDO1↓,
4536- MAG,    Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis
- in-vitro, Liver, HepG2 - in-vivo, CRC, COLO205
AntiCan↑, selectivity↑, TumCCA↑, P21↑, Apoptosis↑,
1898- MeJa,    Methyl jasmonate and its potential in cancer therapy
- Review, Var, NA
ROS↑, selectivity↑, toxicity↝,
1785- MEL,    Antitumoral melatonin-loaded nanostructured lipid carriers
- in-vitro, Var, NA
selectivity↑, TumCD↑,
1781- MEL,    Melatonin in patients with cancer receiving chemotherapy: a randomized, double-blind, placebo-controlled trial
- Trial, Lung, NA
QoL↑, OS∅, selectivity↑,
1778- MEL,    Melatonin: a well-documented antioxidant with conditional pro-oxidant actions
- Review, Var, NA - Review, AD, NA
*ROS↓, *antiOx↓, ROS↑, selectivity↑, Dose↑, *mitResp↑, *ATP↑, *ROS↓, eff↑, ROS↑, Dose↑, *toxicity∅, ROS↑, eff↓, ROS↝, Dose↑, other↑,
1777- MEL,    Melatonin as an antioxidant: under promises but over delivers
- Review, NA, NA
*ROS↓, *Fenton↓, *antiOx↑, *toxicity∅, *GPx↑, *GSR↑, *GSH↑, *NO↓, *Iron↓, *Copper↓, *IL1β↓, *iNOS↓, *Casp3↓, *BBB↑, *RenoP↑, chemoP↑, *Ca+2↝, eff↑, *PKCδ?, ChemoSen↑, eff↑, Akt↓, DR5↑, selectivity↑, ROS↑, eff↑,
5796- MET,    Tumor, whole blood, plasma, and tissue concentrations of metformin in lung cancer patients
- Human, Lung, NA
selectivity↑, AMPK↑, Risk↓, Half-Life↝, ChemoSen↑,
2244- MF,    Little strokes fell big oaks: The use of weak magnetic fields and reactive oxygen species to fight cancer
- Review, Var, NA
RPM↑, Glycolysis∅, ROS↑, ChemoSen↑, RadioS↑, selectivity↑,
2237- MF,    The Effect of Pulsed Electromagnetic Field Stimulation of Live Cells on Intracellular Ca2+ Dynamics Changes Notably Involving Ion Channels
- in-vitro, AML, KG-1 - in-vitro, Nor, HUVECs
Ca+2↑, selectivity↑, *Inflam↓, *TNF-α↓, *NF-kB↓, *Ca+2↓,
2261- MF,    Tumor-specific inhibition with magnetic field
- in-vitro, Nor, GP-293 - in-vitro, Liver, HepG2 - in-vitro, Lung, A549
ROS↑, Ca+2↓, Apoptosis↑, *selectivity↑, TumCG↓, *i-Ca+2↓, i-Ca+2↑,
2260- MF,    Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229 - in-vivo, NA, NA
TumCP↓, TumCG↓, OS↑, ROS↑, SOD2↑, eff↓, ECAR↓, OCR↑, selectivity↑, *toxicity∅, TumVol↓, PGC-1α↑, OXPHOS↑, Glycolysis↓, PKM2↓,
4425- MF,  doxoR,    Brief Magnetic Field Exposure Stimulates Doxorubicin Uptake into Breast Cancer Cells in Association with TRPC1 Expression: A Precision Oncology Methodology to Enhance Chemotherapeutic Outcome
- in-vitro, BC, 4T1 - in-vitro, BC, MCF7
ChemoSen↑, TRPC1↑, Dose↓, selectivity↑,
4354- MF,  doxoR,    Modulated TRPC1 Expression Predicts Sensitivity of Breast Cancer to Doxorubicin and Magnetic Field Therapy: Segue Towards a Precision Medicine Approach
- in-vivo, BC, MDA-MB-231 - in-vivo, BC, MCF7
selectivity↑, Apoptosis↑, TumCI↓, tumCV↓, TumVol↓, eff↓, eff↑, ROS↑, Ca+2↑, TumCMig↓,
5534- MF,    Targeted Osmotic Lysis of Highly Invasive Breast Carcinomas Using Pulsed Magnetic Field Stimulation of Voltage-Gated Sodium Channels and Pharmacological Blockade of Sodium Pumps
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumVol↓, VGSC↑, OS↑, selectivity↑, eff↑,

Showing Research Papers: 351 to 400 of 589
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 589

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

6IL↑, 1,   CTSK↓, 1,   NA↑, 2,   PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   CYP1A1↓, 1,   Ferroptosis↑, 1,   H2O2↓, 1,   lipid-P↑, 1,   OXPHOS↑, 2,   mt-OXPHOS↑, 1,   ROS↓, 1,   ROS↑, 20,   ROS⇅, 1,   ROS↝, 1,   RPM↑, 1,   SOD2↑, 1,   Thiols↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   Insulin↓, 1,   MMP↓, 8,   mtDam↑, 1,   OCR↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 2,   ECAR↓, 1,   glucose↝, 1,   Glycolysis↓, 1,   Glycolysis∅, 1,   IDO1↓, 1,   lactateProd↓, 1,   LDL↓, 1,   lipoGen↓, 1,   NADPH↓, 1,   PKM2↓, 1,   PPARγ↑, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 11,   p‑Akt↓, 2,   Apoptosis↑, 21,   BAX?, 1,   BAX↑, 7,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 6,   Bcl-xL↓, 1,   Casp↑, 1,   Casp3↑, 6,   cl‑Casp3↑, 2,   pro‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 3,   cl‑Casp9↑, 1,   pro‑Casp9↑, 1,   Cyt‑c↑, 6,   Diablo↑, 1,   DR5↑, 1,   Ferroptosis↑, 1,   p‑JNK↑, 1,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 2,   p‑p38↑, 1,   Proteasome↓, 1,   Pyro↑, 1,   TumCD↑, 6,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,   other↝, 1,   pRB↓, 1,   p‑pRB↓, 2,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   GRP78/BiP↓, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3I↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 6,   P53↑, 2,   PARP↓, 1,   cl‑PARP↑, 3,   PCNA↓, 2,   TP53↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 3,   CDK4↓, 3,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 4,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 1,   cycE1↓, 1,   P21↓, 2,   P21↑, 5,   TumCCA↓, 1,   TumCCA↑, 13,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,   CSCs↓, 2,   Diff↑, 2,   EMT↓, 2,   ERK↓, 5,   FOXO4↑, 1,   HH↓, 1,   mTOR↓, 3,   p‑mTOR↓, 1,   NOTCH1↓, 1,   PI3K↓, 7,   p‑PI3K↓, 1,   RAS↓, 1,   STAT3↓, 2,   p‑STAT3↓, 1,   TOP2↑, 1,   TumCG↓, 8,   VGSC↑, 1,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   Ca+2↑, 3,   i-Ca+2↑, 1,   Cofilin↓, 1,   E-cadherin↑, 1,   fascin↓, 1,   Ki-67↓, 2,   MMP2↓, 3,   MMP7↓, 1,   MMP9↓, 4,   MMPs↓, 1,   N-cadherin↓, 1,   PDGF↓, 1,   PKCδ↓, 1,   ROCK1↓, 1,   Snail↓, 1,   TIMP1↓, 1,   TRPC1↑, 1,   TumCI↓, 6,   TumCMig↓, 5,   TumCP↓, 13,   TumMeta↓, 4,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   Endoglin↑, 1,   Hif1a↓, 1,   NO↑, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   FOXP3↓, 1,   ICAM-1↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 1,   Imm↑, 3,   Inflam↓, 3,   JAK2↓, 1,   NF-kB↓, 8,   NK cell↑, 2,   PGE2↓, 1,   TNF-α↓, 4,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 12,   Dose↓, 1,   Dose↑, 4,   Dose↝, 5,   eff↓, 9,   eff↑, 15,   eff↝, 1,   Half-Life↝, 1,   RadioS↑, 1,   selectivity↑, 49,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,   Ki-67↓, 2,   NOS2↑, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↑, 1,   chemoP↑, 4,   neuroP↑, 2,   OS↑, 3,   OS∅, 1,   QoL↑, 3,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 2,   toxicity↓, 3,   toxicity↝, 1,   TumVol↓, 4,   TumW↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 196

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 6,   mt-antiOx↑, 1,   Catalase↑, 1,   Copper↓, 1,   Fenton↓, 1,   GPx↑, 1,   GSH↑, 2,   GSR↑, 1,   Iron↓, 1,   Iron∅, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 8,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   mitResp↑, 1,   MMP↑, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ECAR↓, 1,   GlucoseCon↑, 1,   Glycolysis↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Casp3↓, 1,   Cyt‑c↓, 1,   iNOS↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   Ca+2↝, 1,   i-Ca+2↓, 1,   PKCδ?, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   Inflam↓, 5,   NF-kB↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↑, 1,   BDNF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 2,   eff↑, 1,   eff↝, 1,   selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 3,   cognitive↑, 1,   memory↑, 1,   neuroP↑, 5,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 4,   toxicity∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 56

Scientific Paper Hit Count for: selectivity, selectivity
35 Silver-NanoParticles
27 Magnetic Fields
17 Piperlongumine
16 Radiotherapy/Radiation
14 Selenium NanoParticles
13 Thymoquinone
12 Chemotherapy
12 Betulinic acid
12 Dandelion Root
10 Vitamin C (Ascorbic Acid)
10 chitosan
10 Sulforaphane (mainly Broccoli)
10 Dichloroacetate
10 salinomycin
10 Fisetin
10 Phenethyl isothiocyanate
10 Shikonin
9 Capsaicin
9 Propolis -bee glue
8 doxorubicin
8 Carvacrol
8 Copper and Cu NanoParticles
8 Hydrogen Gas
8 Honokiol
8 Magnetic Field Rotating
8 Quercetin
8 Selenite (Sodium)
7 Artemisinin
7 Berberine
7 Curcumin
6 3-bromopyruvate
6 Fenbendazole
6 Apigenin (mainly Parsley)
6 Baicalein
6 Cisplatin
6 Chrysin
6 EGCG (Epigallocatechin Gallate)
6 Gallic acid
6 HydroxyTyrosol
5 Rosmarinic acid
5 Metformin
5 Ashwagandha(Withaferin A)
5 Melatonin
5 Selenium
5 Ellagic acid
5 Hibiscus sabdariffa
5 Indole-3-carbinol
4 Alpha-Lipoic-Acid
4 Phenylbutyrate
4 Gold NanoParticles
4 Boron
4 α-Bisabolol / Chamomile oil
4 chaetocin
4 diet FMD Fasting Mimicking Diet
4 Eurycomanone
4 Eugenol
4 Graviola
4 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
4 Lycopene
4 Magnolol
4 Parthenolide
4 α-Santalol/Sandalwood oil
4 Terpinen-4-ol / Tea Tree Oil
4 VitK3,menadione
3 1,8-Cineole
3 chemodynamic therapy
3 Allicin (mainly Garlic)
3 Astaxanthin
3 Atorvastatin
3 Caffeic acid
3 Centella asiatica / Gotu kola → asiaticoside
3 Citric Acid
3 Coenzyme Q10
3 Cynaropicrin
3 Date Fruit Extract
3 diet Methionine-Restricted Diet
3 Shilajit/Fulvic Acid
3 γ-linolenic acid (Borage Oil)
3 Helleborus niger extracts – Christmas Rose
3 Isobavachalcone
3 Isoliquiritigenin
3 isoorientin
3 isoquercitrin
3 Nimbolide
3 Urolithin
2 Dipyridamole
2 Berbamine
2 Bifidobacterium
2 immunotherapy
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Crocetin
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Hydroxycinnamic-acid
2 Dihydrocaffeic Acid
2 Docosahexaenoic Acid
2 Oxygen, Hyperbaric
2 D-limonene
2 Disulfiram
2 Electrical Pulses
2 Evodiamine
2 Fucoidan
2 Gambogic Acid
2 Ginkgo biloba
2 Geldanamycin
2 Gossypol/AT-101
2 Hyperthermia
2 Hyperoside
2 Inositol
2 iodine
2 Linalool
2 Luteolin
2 SonoDynamic Therapy UltraSound
2 Plumbagin
2 Sulfasalazine
2 polyethylene glycol
2 Silymarin (Milk Thistle) silibinin
2 Aflavin-3,3′-digallate
2 Vitexin
2 Zerumbone
1 Auranofin
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Glucose
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Sorafenib (brand name Nexavar)
1 5-Aminolevulinic acid
1 Baicalin
1 Bufalin/Huachansu
1 probiotics
1 Brucea javanica
1 Boswellia (frankincense)
1 Butyrate
1 Carnosic acid
1 urea
1 Thymol-Thymus vulgaris
1 Cat’s Claw
1 Cannabidiol
1 Chocolate
1 Calorie Restriction Mimetics
1 Carvone
1 Polyphenols
1 Cucurbitacin
1 Cysteamine
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 Diclofenac
1 diet Ketogenic
1 Docetaxel
1 Dimethyl Sulfoxide
1 Mistletoe/Viscum album Extracts
1 Lemongrass Extract/Citral
1 Echinacea
1 Ginkgo biloba-EGb 761
1 5-fluorouracil
1 PXD, phenoxodiol
1 Emodin
1 Fennel Oil/Foeniculum vulgare
1 ferumoxytol
1 Formononetin
1 olaparib/LYNPARZA
1 Garcinol
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginkgetin
1 Ginseng
1 Grapeseed extract
1 High-Ozonide Oil
1 Paclitaxel/Taxol
1 Gemcitabine (Gemzar)
1 isoflavones
1 Isovitexin
1 Juglone
1 Methylene blue
1 Methyl Jasmonate
1 Methylglyoxal
1 Bicarbonate(Sodium)
1 Oleuropein
1 Propyl gallate
1 temozolomide
1 borneol
1 Psoralidin
1 Pterostilbene
1 Resveratrol
1 irinotecan
1 triptolide
1 Ursolic acid
1 Vitamin B1/Thiamine
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1110  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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