GSH Cancer Research Results

GSH, Glutathione: Click to Expand ⟱
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Glutathione (GSH) is a thiol antioxidant that scavenges reactive oxygen species (ROS), resulting in the formation of oxidized glutathione (GSSG). Decreased amounts of GSH and a decreased GSH/GSSG ratio in tissues are biomarkers of oxidative stress.
Glutathione is a powerful antioxidant found in every cell of the body, composed of three amino acids: cysteine, glutamine, and glycine. It plays a crucial role in protecting cells from oxidative stress, detoxifying harmful substances, and supporting the immune system.
cancer cells can have elevated levels of glutathione, which may help them survive in the oxidative environment created by the immune response and chemotherapy. This can make cancer cells more resistant to treatment.
While glutathione can be obtained from certain foods (like fruits, vegetables, and meats), its absorption from supplements is debated. Some people take N-acetylcysteine (NAC) or other precursors to boost glutathione levels, but the effects on cancer prevention or treatment are still being studied.
Depleting glutathione (GSH) to raise reactive oxygen species (ROS) is a strategy that has been explored in cancer research and therapy.
Many cancer cells have altered redox states and may rely on GSH to survive. Increasing ROS levels can induce stress in these cells, potentially leading to cell death.
Certain drugs and compounds can deplete GSH levels. For example, agents like buthionine sulfoximine (BSO) inhibit the synthesis of GSH, leading to its depletion.
Cancer cells tend to exhibit higher levels of intracellular GSH, possibly as an adaptive response to a higher metabolism and thus higher steady-state levels of reactive oxygen species (ROS).

"...intracellular glutathione (GSH) exhibits an astounding antioxidant activity in scavenging reactive oxygen species (ROS)..."
"Cancer cells have a high level of GSH compared to normal cells."
"...cancer cells are affluent with high antioxidant levels, especially with GSH, whose appearance at an elevated concentration of ∼10 mM (10 times less in normal cells) detoxifies the cancer cells." "Therefore, GSH depletion can be assumed to be the key strategy to amplify the oxidative stress in cancer cells, enhancing the destruction of cancer cells by fruitful cancer therapy."

The loss of GSH is broadly known to be directly related to the apoptosis progression.
Scientific Papers found: Click to Expand⟱
3528- Lyco,    The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2/PTGS2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1/SREBF1↓, *FASN↓, *ACC↓,
3264- Lyco,    Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *GSTs↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *iNOS↓, *NO↓, *TAC↑, *NOX4↓, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *IL1β↓, *TNF-α↓, *TLR2↓, *TLR4↓, *VCAM-1↓, *ICAM-1↓, *STAT3↓, *NF-kB↓, *ERK↓, *BP↓, ROS↓, PGE2↓, cardioP↑, *neuroP↑, *creat↓, *RenoP↑, *CRM↑,
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27/CDKN1B↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2/PTGS2↓, lipid-P↓, GSH↑, NRF2↑,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
1709- Lyco,    Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation
- in-vitro, Nor, JB6
*antiOx↑, *NRF2↑, *GSH/GSSG↓, *Catalase↝, *GR↝, *SOD↝, *GPx↝, *GSH↑, *Keap1↓, *p62↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, Synergy↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
8421- Lyco,    Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *AntiMyl↑, *ROS↓, *MMP↑, *NGF↑, *BDNF↑, *VEGF↑, *Aβ42↓, *PI3K↑, *Akt↑, *NRF2↑, *lipid-P↓, *GSH↑, *Catalase↑, *SOD↑, *cognitive↑, *Learn↑, *memory↑, *APP↓, *BACE/β-secretase↓, *ADAM10↑, *NF-kB↓, *AChE↓, *MAOA↓, *BioAv↝,
8414- Lyco,    Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits
- Review, Var, NA - Review, AD, NA
*ROS↓, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiArt↑, *Obesity↓, *Wound Healing↑, *BioAv↑, *GSTs↑, *Trx1↑, *SOD↑, *Catalase↑, *ALAT↓, *LDH↓, *AST↓, *MDA↓, *cognitive↑, *memory↑, *NeuroI↓, *Aβ↓, *LRP1↑, *RAGE↓, *NRF2↑, *HO-1↑, tumCV?, Bax:Bcl2↑, DNAdam↑, Apoptosis↑, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, ROS↓, TumCCA↑, Akt↓, *Synergy↑, *MDA↓, *NF-kB↓, *TGF-β↓, *Casp3↓, *Catalase↑, *GSH↑, *Bcl-2↑, *IL10↑, *MUC1↑, *IBI↑, *RenoP↑, *ChemoSen↑, *Synergy↑, *Synergy↑, *BMD↑,
4803- Lyco,    Enhanced cytotoxic and apoptosis inducing activity of lycopene oxidation products in different cancer cell lines
- in-vitro, Pca, PC3 - in-vitro, BC, MCF7 - in-vitro, Melanoma, A431 - in-vitro, Liver, HepG2 - in-vitro, Cerv, HeLa - in-vitro, Lung, A549
tumCV↓, GSH↓, MDA↑, ROS↑, Apoptosis↑,
4794- Lyco,    Anticancer Effect of Lycopene in Gastric Carcinogenesis
- Review, GC, NA
*AntiCan↑, *ROS↓, *GSH↑, *GPx↑, *GSTs↑, TumCG↓, Apoptosis↑, ERK↓, Bcl-2↓, BAX↑, Cyt‑c↑, TumCCA↑, *DNAdam↓,
8503- MAG,    Magnolol mitigates neuroinflammation via NF-κB/IL-6/IL-1β pathways in AlCl₃-induced Alzheimer's disease: insights from in-vivo and in-silico investigations
- in-vivo, AD, NA
*Dose↝, *LDH↓, *NO↓, *cognitive↑, *GSH↑, *Catalase↑, *SOD↑, *neuroP↑, *NF-kB↓, *IL6↓, *IL1β↓, *neuroP↑, *ROS↓, *Inflam↓,
8541- Matr,    Matrine induces ferroptosis and suppresses colorectal cancer through targeting the STAT3/SLC7A11 pathway
- in-vivo, CRC, NA
TumCP↓, necrosis↑, Ferroptosis↑, TumCD↑, lipid-P↑, MDA↑, GSH↓, xCT/SLC7A11↓, P53↑, p‑STAT3↓,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8553- Matr,    Research progress on the pharmacological effects of matrine
- Review, Nor, NA
*AntiCan↑, *antiAll↑, *Stroke↓, TumCI↓, TumCMig↓, TumCP↓, TumCCA↑, *AGEs↓, *Inflam↓, *antiOx↑, *neuroP↑, *Apoptosis↓, *IBI↑, *GutMicro↑, EGFR↓, *HSP60/HSPD1↓, *antiOx↑, *GSH↑, *Catalase↑, *AChE↓, *BChE↓, *neuroP↑, *PI3K↑, *Akt↑, *mTOR↑, *cognitive↑, *ROS↓, *toxicity↑,
8552- Matr,    Matrine exerts its neuroprotective effects by modulating multiple neuronal pathways
- Review, AD, NA
*BBB↑, *neuroP↑, *HMGB1↓, *NF-kB↓, *MyD88↓, *TLR4↓, *TRAF6↓, *Cyt‑c↓, *MDA↓, *Beclin-1/ATG6↑, *GPx↑, *IL23↓, *IL17↓, *NRF2↑, *HO-1↑, *SOD↑, *GSH↑, *Stroke↓, *BACE/β-secretase↓, *Aβ↓, *BDNF↑, *AChE↓, *BChE↓, *ROS↓, *memory↑, *NP/CIPN↓,
8549- Matr,    Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis
- in-vitro, Var, NA
toxicity↑, *hepatoP↓, *SOD↓, *GSH↓, *MDA↑, *ROS↑, *lipid-P↑, *Iron↝, *Ferroptosis↑, *FTH1↓, *NRF2↓, *xCT/SLC7A11↓, *GPx4↓, *HO-1↓, *toxicity↝,
8545- Matr,    Matrine enhances RLS3-induced ferroptosis at non-toxic doses in acute myeloid leukemia cells with MLL rearrangement
- in-vitro, AML, MV411 - in-vitro, ALL, MOLM-13
Ferroptosis↑, Synergy↑, i-Iron↑, ROS↑, MMP↓, GSH↓, xCT/SLC7A11↓, GPx4↓, P53↑,
8723- MeJa,    Methyl Jasmonate Reduces Inflammation and Oxidative Stress in the Brain of Arthritic Rats
- in-vivo, Arthritis, NA
*Dose?, *lipid-P↓, *ROS↓, *Catalase↑, *SOD↑, *GSH↑, *IDH1↑, *NADPH↑, *HK2↑,
8752- MeSA,  Rad,    Methylseleninic Acid Induces Lipid Peroxidation and Radiation Sensitivity in Head and Neck Cancer Cells
- in-vitro, HNSCC, CAL27 - in-vitro, SCC, SCC25
selectivity↑, RadioS↑, GSH↓, lipid-P↑, OCR↑,
8756- MeSA,    THE MAIN CYTOTOXIC EFFECTS OF METHYLSELENINIC ACID ON VARIOUS CANCER CELLS
- Review, Var, NA
ROS↑, GSH↓, RadioS↑, angioG↓, p‑Akt↓, IκB↓, NF-kB↓, ITGB3↓, p‑FOXO3↓, BAX↑, Cyt‑c↑, proCasp3↑, PARP↑, Glycolysis↓, TCA↓, NRF2↑, DNMT1↓, Hif1a↓, ER Stress↑, ChemoSen↑,
8746- MeSA,    Inhibition of androgen receptor signaling by selenite and methylseleninic acid in prostate cancer cells: two distinct mechanisms of action
- in-vitro, Nor, LAPC-4 - in-vitro, Pca, LNCaP
AR↓, GSH↝, PSA↓,
1204- MET,    Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
MDA↑, ROS↑, Iron↑, GSH↓, T-SOD↓, Catalase↓, GPx4↓, xCT/SLC7A11↓, NRF2↓, HO-1↓,
8486- MF,    Silent forces, hidden currents: the influence of static magnetic field stimulation on tumor biophysics
- Review, Var, NA
Ca+2↑, TumCG↓, MMP↓, CellMemb↑, SOX2↓, Nanog↓, cMyc↓, CD44↓, CD133↓, P53↑, ROS↑, DNAdam↑, CDK1↓, CycB/CCNB1↓, TumCCA↑, TumCP↓, pH↓, TumCP↓, Telomerase↓, ChemoSen↑, TRPV1↝, Bax:Bcl2↑, Casp3↑, Akt↓, mTOR↓, mitA↑, ROS↓, P-gp/ABCB1↓, MDR1↓, RadioS↑, Apoptosis↑, GSH↓, lipid-P↑, Iron↑, Iron↓, Fenton↑,
3463- MF,    Pulsed Electromagnetic Fields Alleviates Hepatic Oxidative Stress and Lipids Accumulation in db/db mice
- in-vivo, Nor, NA
*hepatoP↑, *MDA↓, *GSSG↓, *GSH↑, *GPx↑, *antiOx↑, *SREBP1/SREBF1↓,
8479- MFrot,  doxoR,    Dual-targeting by rotating magnetic field-driven superparamagnetic bionic nanorobots for enhanced triple-negative breast cancer therapy
- vitro+vivo, BC, 4T1
Dose?, EPR↑, BioEnh↑, GSH↓, GPx4↓, Iron↑, ROS↑, lipid-P↑, Ferroptosis↑, TumVol↓, Fenton↑,
186- MFrot,  MF,    Selective induction of rapid cytotoxic effect in glioblastoma cells by oscillating magnetic fields
- in-vitro, GBM, GBM - in-vitro, Lung, NA
mt-ROS↑, Casp3↑, selectivity↑, TumCD↑, ETC↓, H2O2↑, eff↓, GSH↑, MMP↓,
184- MFrot,  MF,    Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells
- in-vitro, GBM, GBM
ROS↑, mitResp↓, mtDam↑, Dose↝, MMP?, OCR↓, mt-H2O2↑, eff↓, SDH↓, Thiols↓, GSH↓, TumCD↑, Casp3↑, Casp7↑, MPT↑, Cyt‑c↑, selectivity↑, GSH/GSSG↓, ETC↓,
8670- MLT,    Antitumor Effects of Melatonin in Luminal and Triple-Negative Breast Cancer Cells: Metabolic Reprogramming, Redox Regulation, and Cellular Dynamics
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, TumCMig↓, TumCI↓, GAPDH↓, Hif1a↓, citrate↓, ROS↑, lipid-P↑, LDH↓, G6PD↓, MDA?, Catalase↓, GPx↑, GSH↑, *ROS↓,
8663- MLT,    Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect
- vitro+vivo, RCC, 786-O
TumCG↓, ROS↑, TAC↓, TCA↑, Glycolysis↓, OCR↑, ATP↑, MMP↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, VEGFR1↓, eff↓, Synergy↑, Warburg↓, TumCP↓, SOD↓, GSH↓, Catalase↓, GPx↑, Warburg↓, OXPHOS↑, Hif1a↓, VEGF↓, Ki-67↓, Akt↓, mTOR↓,
8689- MLT,    Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *NeuroI↓, *Apoptosis↓, *mtDam↓, *GSK‐3β↓, *p‑tau↓, *GFAP↓, *TNF-α↓, *IL6↓, *BACE/β-secretase↓, *PSEN1/PS1↓, *NF-kB↓, *TFAM↑, *Nrf1↑, *NRF2↑, *PGC-1α↑, *MMP↑, *GSH↑, *lipid-P↓, *ChAT↑, *TBARS↓, *SOD↑, *Ca+2↓, *AChE↓, *H2O2↓, *MDA↓, *TAC↑, *SOD↑, *Catalase↑, *BDNF↑, *Bcl-2↑, *Ach↑, *memory↑, *Learn↑, *GSK‐3β↓, *SNAP25↑, *PSD95↑, *p‑CREB↑, *GFAP↓, *RELN↑, *SIRT1↑, *TFAM↑, *APP↓, *ER Stress↓, *GRP78/BiP↓, *Sleep↑, *cognitive↑, *Synergy↑, *NeuroI↓,
1777- MLT,    Melatonin as an antioxidant: under promises but over delivers
- Review, Var, NA
*ROS↓, *Fenton↓, *antiOx↑, *toxicity∅, *GPx↑, *GSR↑, *GSH↑, *NO↓, *Iron↓, *Copper↓, *IL1β↓, *iNOS↓, *Casp3↓, *BBB↑, *RenoP↑, chemoP↑, *Ca+2↝, eff↑, *PKCδ?, ChemoSen↑, eff↑, Akt↓, DR5↑, selectivity↑, ROS↑, Synergy↑,
1780- MLT,    Utilizing Melatonin to Alleviate Side Effects of Chemotherapy: A Potentially Good Partner for Treating Cancer with Ageing
- Review, Var, NA
*antiOx↑, *toxicity↓, ChemoSen↑, *eff↑, *mitResp↑, *ATP↑, *ROS↓, *CardioT↓, *GSH↑, *NOS2↓, *lipid-P↓, eff↑, *HO-1↑, *NRF2↑, *NF-kB↑, TumCP↓, eff↑, neuroP↑,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
1063- MLT,    HDAC1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways
- in-vitro, Lung, A549 - in-vitro, Lung, PC9
AntiCan↑, TumCMig↓, GSH↓, Casp3↑, Apoptosis↑, ROS↑, HDAC1↓, Ac-histone H3↑, PUMA↑, BAX↑, PCNA↓, Bcl-2↓,
3839- MO,    Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation
- in-vitro, AD, NA
*eff↑, *ROS↓, *lipid-P↓, *GSH↑, *antiOx↑, *Ca+2↓, *MMP↑, *neuroP↑, *BBB↑, *Catalase↑, *SOD↑, GPx↑,
8619- MO,  doxoR,    Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells
- vitro+vivo, BC, MCF7
*Dose↝, *cardioP↑, *ROS↓, *lipid-P↓, *antiOx↑, *Inflam↓, *NF-kB↓, *TNF-α↓, *COX2/PTGS2↓, *MPO↓, ChemoSen↑, *Dose↝, *AST↓, *CK/CK-MB↓, *SOD↑, Synergy↑, MDA↑, NO↑, GSH↓, ROS↑,
8875- MOR,    Neuroprotective Effect of Morin Against Chemical-Induced Neurotoxicities and Neurodegenerative Disease Models
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *chemoP↑, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *ROS↓, *MDA↓, *NO↓, *TLR4↓, *NF-kB↓, *ERK↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *NLRP3↓,
8872- MOR,    Morin attenuates memory deficits in a rat model of Alzheimer's disease by ameliorating oxidative stress and neuroinflammation
- in-vivo, AD, NA
*Dose↝, *MDA↓, *NO↓, *GSH↑, *Catalase↑, *TNF-α↓, *IL1β↓, *IL6↓, *NF-kB↓, *BDNF↑, *antiOx↑, *NeuroI↓, *memory↑,
8863- MOR,    Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect
- in-vitro, Colon, SW48
TumCP↓, Apoptosis↑, ROS↑, MMP↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, ATP↓, GlucoseCon↓, GLUT1↓, Warburg↓, Dose↝, Catalase↓, GSH↓, ADP:ATP↑, AMP↑,
8879- MOR,  doxoR,    Synergistic Effects of Morin and Doxorubicin Overcome Chemoresistance in Ovarian Cancer: Preclinical Insights From in vitro and in vivo Models
- vitro+vivo, Ovarian, OVCAR-3 - NA, Melanoma, A2780S
Dose↝, ChemoSen↑, cycA1/CCNA1↓, cycD1/CCND1↓, TumVol↓, Apoptosis↑, TumCCA↑, ROS↝, chemoP↑, TumAuto↑, ROS↓, SOD↑, Catalase↑, GSH↑, MDA↓, cardioP↑, mTOR↓, PI3K↓, Akt↓, Bcl-2↓, Casp3↑, Casp9↑, LC3A↑, ATG5↑, Beclin-1/ATG6↑,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *Synergy↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,
3848- MSM,    Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway
- in-vitro, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *ER(estro)↑, *NRF2↑, *HO-1↑, *Trx1↑, *TXNIP↓, *MDA↓, *NOX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *BDNF↑, *AChE↓, *p‑tau↓, *Aβ↓,
3811- mushLions,    Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment
- in-vitro, AD, NA
*memory↑, *BBB↑, *GSH↑, *AChE↓, *MDA↓,
1273- Myr,    Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4
- vitro+vivo, GC, NA
Ferroptosis↑, MDA↑, Iron↑, GSH↓, NOX4↑, NRF2↓, GPx4↓,
4167- NAC,    N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action
- Review, Nor, NA
*GSH↑, *antiOx↑, *ROS↓,
1799- NarG,    Naringenin as potent anticancer phytocompound in breast carcinoma: from mechanistic approach to nanoformulations based therapeutics
- Review, BC, NA
TumCCA↑, BioAv↑, Half-Life∅, TNF-α↓, Casp8↑, BAX↑, Bak↑, EGF↓, mTOR↓, PI3K↓, ERK↓, Akt↓, NF-kB↓, VEGF↓, angioG↓, antiOx↑, EMT↓, OS↑, MAPK↓, ChemoSen↑, MMP9↓, MMP2↓, ROS↑, ROS↑, GSH↓, Casp3↑, ROS↑,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP/DDIT3↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27/CDKN1B↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
8453- OM,    Origanum majorana Attenuates Nephrotoxicity of Cisplatin Anticancer Drug through Ameliorating Oxidative Stress
- in-vivo, Nor, NA
Dose↝, creat↓, Urea↓, uricA↓, BUN↓, MDA↓, GSH↑, SOD↑, Catalase↑, RenoP↑, *ROS↓,

Showing Research Papers: 351 to 400 of 640
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 640

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 2,   antiOx↓, 5,   antiOx↑, 13,   antiOx⇅, 1,   Catalase↓, 26,   Catalase↑, 15,   Copper↑, 1,   cystine↓, 1,   Fenton↑, 11,   GCLM↑, 2,   GPx↓, 11,   GPx↑, 16,   GPx1↓, 1,   GPx1⇅, 1,   GPx4↓, 46,   GPx4↑, 1,   GSH?, 1,   GSH↓, 272,   GSH↑, 38,   GSH⇅, 2,   GSH↝, 2,   GSH∅, 3,   i-GSH↓, 1,   i-GSH∅, 1,   mt-GSH↓, 1,   GSH/GSSG↓, 8,   GSR↓, 3,   GSR↑, 5,   GSSG↓, 1,   GSSG↑, 7,   GSTs↓, 2,   GSTs↑, 8,   H2O2↓, 3,   H2O2↑, 16,   mt-H2O2↑, 1,   HO-1↓, 9,   HO-1↑, 18,   HO-1⇅, 1,   HO-2↑, 1,   Iron↓, 1,   Iron↑, 31,   Iron↝, 2,   i-Iron↑, 4,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↓, 8,   lipid-P↑, 43,   lipid-P↝, 1,   MDA?, 1,   MDA↓, 12,   MDA↑, 41,   i-MDA↑, 1,   MPO↓, 1,   NADH↓, 1,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 2,   NQO1↓, 3,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↓, 26,   NRF2↑, 28,   NRF2⇅, 1,   NRF2∅, 1,   Prx4↑, 1,   PYCR1↓, 1,   RNS↓, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 29,   ROS↑, 267,   ROS⇅, 6,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 3,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 27,   SOD↑, 20,   SOD1↑, 3,   SOD2↓, 3,   SOD2↑, 3,   T-SOD↓, 1,   TAC↓, 3,   TBARS↓, 1,   TBARS↑, 4,   Thiols↓, 7,   i-Thiols↓, 1,   TOS↑, 1,   Trx↓, 6,   Trx1↓, 1,   Trx2↓, 1,   TrxR↓, 11,   TrxR1?, 1,   TrxR1↓, 1,   uricA↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 21,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FTH1↓, 5,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 4,   Mets↑, 1,   NCOA4↑, 3,   Zn2+↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 1,   CDC25↝, 1,   compI↓, 5,   compII↓, 3,   compIII↓, 2,   compV↓, 1,   EGF↓, 2,   ETC↓, 6,   Insulin↓, 3,   mitResp↓, 6,   mtDam↓, 1,   mtDam↑, 20,   OCR↓, 2,   OCR↑, 2,   OXPHOS↓, 3,   OXPHOS↑, 1,   mt-OXPHOS↓, 2,   PDH↓, 1,   PDH↑, 1,   SDH↓, 1,   SIRT3↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACSL4↑, 4,   ALAT↓, 7,   AMP↑, 1,   AMPK↑, 12,   p‑AMPK↑, 1,   ATP↓, 25,   ATP↑, 2,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   citrate↓, 1,   ECAR↓, 1,   ENO1↓, 1,   FAO↓, 1,   FAO↑, 1,   FASN↓, 3,   FDG↓, 1,   G6PD↓, 3,   GAPDH↓, 4,   GLO-I↓, 1,   GLS↓, 2,   glucose↓, 3,   GlucoseCon↓, 5,   GlucoseCon∅, 1,   GlutaM↓, 1,   GlutMet↓, 1,   Glycolysis↓, 26,   GSK‐3β↓, 5,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 4,   ac‑Histones↑, 1,   HK1↓, 1,   HK2↓, 14,   lactateProd↓, 7,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 2,   LDL↓, 2,   MethCyc↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 4,   NADPH↑, 2,   PDK1 / PDPK1↓, 2,   PFKP↓, 2,   PKM2↓, 7,   polyA↓, 1,   PPP↓, 1,   PPP↑, 1,   Pyruv↓, 1,   RNR↓, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 5,   SIRT2↑, 1,   SREBP2↓, 1,   TCA↓, 4,   TCA↑, 1,   TS↓, 1,   Warburg↓, 7,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 3,   Apoptosis↓, 5,   Apoptosis↑, 138,   mt-Apoptosis↑, 1,   ASC↓, 1,   ASK1↑, 1,   BAD↑, 7,   Bak↓, 1,   Bak↑, 5,   BAX↓, 4,   BAX↑, 78,   Bax:Bcl2↑, 14,   Bcl-2↓, 78,   Bcl-2↑, 3,   Bcl-xL↓, 15,   Bcl-xL↑, 1,   BID↑, 4,   BIM↓, 1,   BIM↑, 3,   BNIP3↝, 1,   BOK↑, 1,   Casp↑, 15,   Casp↝, 1,   Casp1↓, 1,   Casp10↑, 1,   Casp12↑, 2,   cl‑Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 100,   cl‑Casp3↓, 1,   cl‑Casp3↑, 12,   cl‑Casp3∅, 1,   proCasp3↑, 3,   Casp6↑, 1,   Casp7↑, 16,   cl‑Casp7↑, 1,   Casp8↑, 26,   cl‑Casp8↑, 2,   Casp9↓, 2,   Casp9↑, 57,   cl‑Casp9↓, 1,   cl‑Casp9↑, 7,   proCasp9↑, 1,   cFLIP↓, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 58,   mt-Cyt‑c↓, 1,   Diablo↑, 5,   DR5↓, 1,   DR5↑, 12,   FADD↑, 3,   Fas↑, 15,   FasL↑, 3,   Ferroptosis↓, 2,   Ferroptosis↑, 57,   GranB/GZMB↝, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   iNOS↓, 9,   Mcl-1↓, 7,   MDM2↓, 3,   p‑MDM2↓, 1,   MOMP↑, 1,   NAIP↓, 1,   Necroptosis↑, 2,   necrosis↑, 5,   p38↑, 14,   p‑p38↑, 3,   Paraptosis↑, 1,   Perforin↝, 1,   pS2/TFF1↓, 1,   PUMA↑, 4,   Pyro↑, 2,   RIP1↑, 3,   RIP3↑, 3,   survivin↓, 19,   TNFR 1↑, 1,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↓, 2,   TumCD↑, 16,   XIAP↓, 18,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 65,   Akt↑, 4,   p‑Akt↓, 13,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 3,   BRAF↑, 1,   BRAF↝, 1,   CaMKII ↓, 1,   CK2↓, 1,   cMET↓, 3,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 12,   EGFR↑, 2,   ERK↓, 29,   ERK↑, 4,   p‑ERK↓, 3,   p‑ERK↑, 1,   FGFR1↓, 2,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   HRAS↓, 1,   IGF-1R↓, 4,   IKKα↓, 5,   IKKα↑, 1,   IκB↓, 1,   p‑IκB↓, 1,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 5,   JNK↓, 3,   JNK↑, 13,   p‑JNK↓, 1,   p‑JNK↑, 3,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 15,   MAPK↑, 15,   MAPK↝, 2,   p‑MAPK↓, 1,   p‑MAPK↑, 2,   MEK↓, 1,   p‑MEK↓, 2,   mTOR↓, 36,   p‑mTOR↓, 4,   mTORC2↓, 1,   p70S6↓, 1,   P70S6K↓, 3,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PI3K↓, 41,   PI3K↑, 2,   PI3K↝, 1,   p‑PI3K↓, 4,   PI3K/Akt↓, 1,   PI3K/Akt⇅, 1,   PI3K/Akt↝, 1,   PKCδ↓, 4,   PTEN↓, 2,   PTEN↑, 7,   PTEN↝, 1,   Raf↓, 6,   RAS↓, 6,   RAS↑, 1,   RET↓, 1,   Sp1/3/4↓, 8,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 35,   p‑STAT3↓, 7,   STAT6↓, 2,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   ATF3↑, 2,   ATF4↑, 9,   ATF4↝, 1,   ATFs↑, 1,   cJun↓, 1,   cMyc↓, 25,   DNMT1↓, 4,   DNMT1↑, 1,   DNMT3B↓, 1,   DNMTs↓, 3,   EZH2↓, 1,   FOXM1↓, 1,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 4,   p‑FOXO3↓, 3,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 1,   ac‑H3↓, 1,   H4↓, 1,   ac‑H4↓, 1,   HATs↑, 1,   HDAC↓, 14,   HDAC1↓, 5,   HDAC2↓, 4,   HDAC3↓, 3,   HDAC8↓, 1,   miR-107↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-21↓, 3,   miR-21↑, 1,   miR-22↑, 1,   miR-224↓, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 3,   miR-384↑, 1,   miR-422a↑, 1,   Myc↓, 1,   MYCN↓, 1,   OCT4↓, 5,   other↓, 7,   other↑, 8,   other⇅, 1,   other↝, 6,   PAX2↓, 1,   PhotoS↑, 3,   SALL4↓, 1,   sonoS↑, 3,   SOX2↓, 6,   SOX4↓, 1,   SOX4↑, 1,   SOX9↓, 1,   TCF-4↓, 1,   tumCV?, 1,   tumCV↓, 40,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   CHOP/DDIT3↑, 17,   eIF2α↓, 1,   eIF2α↑, 5,   p‑eIF2α↑, 3,   ER Stress↑, 29,   GRP78/BiP↑, 8,   HSP27↓, 3,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 3,   HSP90↓, 6,   HSPs↑, 1,   IRE1↑, 2,   PERK↑, 6,   p‑PERK↑, 1,   UPR↑, 5,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   autolysosome↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 10,   p‑Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3A↑, 2,   LC3B↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 8,   LC3s↑, 1,   p62↓, 5,   p62↑, 2,   TumAuto↑, 17,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↑, 1,   BRCA2↑, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 46,   mt-DNAdam↑, 1,   DNArepair↓, 2,   DNArepair↑, 1,   ERCC3↑, 1,   hTERT/TERT↓, 2,   p16↑, 1,   P53↓, 4,   P53↑, 66,   P53↝, 1,   p‑P53↑, 2,   p53 Wildtype↓, 1,   PARP↓, 2,   PARP↑, 8,   cl‑PARP↓, 1,   cl‑PARP↑, 32,   cl‑PARP∅, 1,   PARP1↑, 2,   cl‑PARP1↑, 1,   PCNA↓, 21,   SIRT6↓, 2,   Telomerase↓, 5,   TOP1↓, 1,   TOP1∅, 1,   TOP2↓, 2,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 9,   CDK1↑, 4,   CDK1↝, 1,   CDK2↓, 16,   CDK2↑, 2,   CDK4↓, 21,   CDK4↑, 1,   CDK6↓, 7,   CDK7↓, 1,   CDK8↓, 1,   CHK1↓, 2,   CHK1↝, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   Cyc↓, 3,   cycA1/CCNA1↓, 4,   CycB/CCNB1↓, 15,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 35,   cycE/CCNE↓, 9,   GADD45A↑, 2,   Ki-67↓, 21,   mitA↑, 2,   P21↓, 3,   P21↑, 41,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 15,   pRB↓, 1,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   Securin↓, 1,   TumCCA↓, 2,   TumCCA↑, 108,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   BMP7/OP1↓, 2,   BMPs↑, 2,   CD133↓, 3,   CD34↓, 1,   cFos↓, 2,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 15,   Diff↑, 2,   EIF4E↓, 1,   EP4/PTGER4↑, 1,   FGF↓, 2,   FOSL1↑, 1,   GDF15↓, 1,   Gli1↓, 1,   HH↓, 1,   IGF-1?, 1,   IGF-1↓, 6,   IGFBP3↑, 2,   Ki-67↓, 21,   mTORC1↓, 2,   Nanog↓, 6,   Nestin↓, 1,   NOTCH↓, 3,   NOTCH1↓, 8,   SCF↓, 1,   Shh↓, 3,   STAT1↓, 1,   TumCG↓, 68,   TumCG↑, 2,   TumCP?, 1,   TumCP↓, 94,   Wnt↓, 12,   Wnt↝, 1,   Zn2+↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 6,   ASAP2↓, 1,   AXL↓, 2,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↓, 3,   Ca+2↑, 15,   Ca+2↝, 1,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   CD11b↑, 1,   Cdc42↓, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 16,   EMT↓, 35,   EMT↑, 1,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 2,   FAK↓, 4,   p‑FAK↓, 1,   ITGB1↓, 2,   ITGB3↓, 1,   ITGB6↓, 1,   KRAS↓, 2,   LAMs↓, 1,   LEF1↓, 2,   LRP1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 3,   MMP13↓, 3,   MMP16↓, 1,   MMP2↓, 38,   MMP3↓, 2,   MMP7↓, 3,   MMP9↓, 40,   MMP9↑, 1,   MMPs↓, 17,   MTA1↓, 1,   MUC1-C↓, 1,   MUC4↓, 1,   N-cadherin↓, 15,   PCBP1↓, 1,   PDGF↓, 1,   proline↓, 1,   Rac1↓, 1,   Rho↓, 1,   Rho↝, 1,   ROCK1↓, 1,   Slug↓, 5,   Smad1↑, 1,   SMAD2↓, 1,   Snail↓, 8,   TET1↑, 1,   TGF-β↓, 3,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 4,   TIMP3↑, 1,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↑, 1,   TumCI↓, 38,   TumCMig↓, 39,   TumCMig↑, 1,   TumMeta↓, 29,   TumMeta↑, 4,   TumPF↓, 1,   Twist↓, 8,   Tyro3↓, 1,   uPA↓, 6,   uPAR↓, 2,   Vim↓, 16,   Vim↑, 1,   Zeb1↓, 4,   ZEB2↓, 1,   β-catenin/ZEB1↓, 21,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 42,   CD31/PECAM-1↓, 3,   EGR1↑, 1,   EGR4↓, 1,   HIF-1↓, 1,   HIF-1↑, 1,   Hif1a↓, 27,   LOX1↓, 1,   NO↓, 4,   NO↑, 10,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 43,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CellMemb↑, 1,   CLDN1↓, 2,   CLDN1↑, 1,   CTR1↑, 1,   EPR↑, 1,   GLUT1↓, 5,   GLUT1↑, 1,   GLUT3↑, 1,   IBI↑, 1,   MMP?, 1,   MMP↓, 93,   MMP↑, 2,   MPT↑, 1,   OCLN↑, 1,   SLC12A5↓, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPV1↝, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   CD4+↑, 1,   CD44↓, 8,   CD8+↑, 1,   COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 44,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCR3↓, 1,   CXCR4↓, 9,   DR4↑, 3,   FOXP3↓, 1,   HMGB1↓, 4,   ICAM-1↓, 4,   IFN-γ↓, 4,   IFN-γ↑, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 2,   IL10↑, 2,   IL12↓, 1,   IL12↑, 1,   IL1β↓, 10,   IL1β↑, 2,   IL2↓, 3,   IL2↑, 4,   IL4↓, 1,   IL4↑, 2,   IL6↓, 27,   IL8↓, 10,   Imm↑, 8,   INF-γ↝, 1,   Inflam↓, 22,   LRIG1↑, 1,   pol-M1↑, 1,   MCP1/CCL2↓, 2,   MCT1↓, 1,   MDSCs↓, 1,   MIP2↓, 1,   Neut↑, 1,   NF-kB↓, 77,   NF-kB↑, 3,   p‑NF-kB↓, 1,   NK cell↑, 7,   NLRP3↓, 4,   NLRP3↑, 1,   p50↓, 2,   p65↓, 4,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 8,   PGE1↓, 1,   PGE2↓, 11,   PSA↓, 8,   PSA∅, 1,   RAGE↓, 1,   Resistin↓, 1,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 1,   TLR1↑, 1,   TLR4↓, 4,   TLR4↝, 1,   TNF-α↓, 26,   TNF-α↑, 6,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   pH↝, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   PRNP↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 2,   AR↓, 9,   ER-α36↓, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARγ↓, 1,   PPARγ↑, 3,   PPARγ↝, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 1,   BioAv↓, 19,   BioAv↑, 13,   BioAv↝, 10,   BioEnh↑, 2,   chemoR↓, 1,   ChemoSen↓, 2,   ChemoSen↑, 108,   CompStab↓, 2,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   DDS↑, 1,   Dose?, 1,   Dose↓, 2,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 36,   Dose∅, 4,   eff?, 1,   eff↓, 51,   eff↑, 65,   eff↝, 5,   GSTA1↓, 1,   GSTA1↑, 1,   GSTM1↑, 1,   GSTP1/GSTπ↓, 2,   Half-Life?, 1,   Half-Life↓, 4,   Half-Life↝, 7,   Half-Life∅, 1,   MDR1↓, 4,   MRP1/ABCC1↓, 4,   P-gp/ABCB1↓, 13,   P-gp/ABCB1↑, 1,   P450↓, 3,   RadioS↓, 1,   RadioS↑, 38,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 71,   Synergy↑, 50,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 7,   ALP↓, 2,   AR↓, 9,   AST↓, 4,   BMD↑, 1,   BP↓, 1,   BRAF↑, 1,   BRAF↝, 1,   BRCA1↑, 1,   BUN↓, 3,   CEA↓, 2,   creat↓, 3,   CRP↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 12,   EGFR↑, 2,   ERα/ESR1↓, 1,   EZH2↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 27,   KRAS↓, 2,   LDH↓, 8,   LDH↑, 4,   LDH↝, 1,   Myc↓, 1,   NSE↓, 1,   PC↑, 1,   PD-L1↓, 8,   PSA↓, 8,   PSA∅, 1,   RAGE↓, 1,   RBC↑, 1,   TG/TAG↓, 1,   TRIB3↑, 1,   Urea↓, 1,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 43,   antiCG↓, 1,   antiNeop↑, 1,   AntiTum↑, 9,   BowelM↑, 1,   cachexia↓, 2,   cardioP↑, 9,   CardioT↓, 1,   chemoP↑, 29,   chemoPv↑, 14,   ChemoSideEff↓, 7,   cognitive↑, 5,   fatigue↓, 1,   fatigue∅, 1,   hepatoP↑, 15,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 11,   NP/CIPN↓, 1,   OS↓, 1,   OS↑, 15,   Pain↓, 2,   Pin1↓, 2,   QoL↑, 4,   QoL∅, 1,   radioP↑, 8,   Remission↑, 1,   RenoP↑, 8,   Risk↓, 3,   toxicity↓, 6,   toxicity↑, 4,   toxicity↝, 2,   TumVol?, 1,   TumVol↓, 9,   TumW↓, 6,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 3,   GutMicro↑, 2,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,  
Total Targets: 889

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx?, 1,   antiOx↓, 9,   antiOx↑, 162,   ARE↑, 4,   Bil↓, 1,   Catalase↓, 7,   Catalase↑, 132,   Catalase↝, 1,   Copper↓, 2,   Fenton↓, 3,   GCLC↑, 3,   GCLM↑, 2,   GPx↓, 2,   GPx↑, 84,   GPx↝, 1,   GPx∅, 1,   GPx1↑, 1,   GPx4↓, 1,   GPx4↑, 7,   GSH↓, 17,   GSH↑, 321,   GSH⇅, 1,   GSH∅, 2,   GSH/GSSG↓, 1,   GSH/GSSG↑, 2,   GSR↓, 3,   GSR↑, 19,   GSS↑, 1,   GSSG↓, 5,   GSSG∅, 1,   GSTs↓, 4,   GSTs↑, 28,   H2O2↓, 12,   H2O2↑, 1,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 6,   HNE↓, 1,   HO-1↓, 4,   HO-1↑, 87,   HO-1⇅, 1,   HO-2↓, 1,   Iron↓, 3,   Iron↝, 1,   i-Iron↓, 1,   i-Iron↑, 1,   Keap1↓, 7,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 97,   lipid-P↑, 3,   MDA↓, 136,   MDA↑, 7,   MPO↓, 15,   MPO↑, 1,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 3,   NQO1↑, 21,   Nrf1↑, 3,   NRF2↓, 6,   NRF2↑, 144,   NRF2⇅, 1,   Prx↑, 5,   RNS↓, 3,   ROS?, 2,   ROS↓, 263,   ROS↑, 13,   ROS⇅, 2,   ROS∅, 5,   i-ROS↑, 1,   mt-ROS?, 1,   mt-ROS↓, 1,   selenoP↑, 1,   SOD?, 1,   SOD↓, 9,   SOD↑, 190,   SOD↝, 1,   SOD1↓, 2,   SOD1↑, 4,   SOD2↑, 4,   TAC↑, 16,   TBARS↓, 9,   TBARS↑, 1,   Thiols↑, 1,   TOS↓, 2,   Trx↑, 7,   Trx1↑, 3,   TrxR↑, 3,   TrxR1↑, 1,   uricA↓, 2,   VitC↑, 11,   VitE↑, 8,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 2,   FPN↑, 1,   FTH1↓, 1,   IronCh↓, 1,   IronCh↑, 19,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 2,   FIS1↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN2↑, 2,   mitResp↑, 2,   mtDam↓, 6,   mtDam↑, 1,   NGB↑, 1,   OCR↑, 1,   PDH↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   SIRT3↑, 2,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 5,   ACC↓, 1,   ACC↑, 1,   Acetyl-CoA↑, 2,   ACSL4↓, 1,   adiP↓, 1,   adiP↑, 1,   ALAT↓, 49,   ALAT↑, 1,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 15,   AMPK⇅, 1,   ATP↓, 2,   ATP↑, 14,   cAMP↑, 1,   CRM↑, 2,   FAO↑, 1,   FASN↓, 3,   G6PD↑, 1,   GAPDH↑, 1,   glucose↓, 7,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↓, 1,   GlucoseCon↑, 12,   GlutMet↑, 1,   Glycolysis↑, 1,   Glycolysis↝, 1,   GSK‐3β↓, 10,   GSK‐3β↑, 5,   H2S↑, 4,   HK2↓, 1,   HK2↑, 2,   HMG-CoA↓, 2,   IDH1↑, 1,   lactateProd↓, 1,   LDHA↓, 1,   LDHA↑, 1,   LDL↓, 16,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 7,   NADPH↑, 6,   NADPH∅, 1,   PDKs↓, 1,   PFK↓, 1,   PFK↑, 1,   PFK2↓, 1,   PGC1A↑, 1,   PIP3↑, 1,   PKM2↓, 1,   PKM2↑, 1,   PLA2↓, 1,   PONs↑, 1,   PPP↓, 1,   SIRT1↓, 1,   SIRT1↑, 18,   SIRT2↑, 1,   SREBP1/SREBF1↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 27,   ASC↓, 1,   BAD↓, 1,   BAX↓, 20,   BAX↑, 3,   Bax:Bcl2↓, 2,   Bcl-2↓, 3,   Bcl-2↑, 18,   Bcl-2↝, 1,   Casp↓, 1,   Casp1↓, 3,   Casp3↓, 38,   Casp3↑, 1,   cl‑Casp3↓, 5,   proCasp3↓, 1,   Casp7↓, 1,   Casp8↓, 2,   Casp9↓, 14,   cl‑Casp9↓, 1,   Cyt‑c↓, 10,   Cyt‑c↑, 1,   Fas↓, 1,   Ferroptosis↓, 8,   Ferroptosis↑, 2,   GSDMD↓, 1,   iNOS↓, 43,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 5,   p38↑, 2,   p‑p38↓, 3,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 7,   Akt↑, 19,   p‑Akt↓, 1,   p‑Akt↑, 1,   AMPKα↑, 1,   CREB↑, 2,   p‑CREB↑, 3,   ERK↓, 7,   ERK↑, 7,   p‑ERK↓, 2,   p‑ERK↑, 1,   HCAR2↑, 1,   HGF/c-Met↑, 1,   IKKα↓, 2,   IKKα↑, 1,   p‑IKKα↓, 1,   JAK2↓, 1,   p‑JAK2↓, 1,   JNK↓, 10,   JNK↑, 1,   p‑JNK↓, 4,   MAPK?, 1,   MAPK↓, 15,   MAPK↑, 6,   MAPK↝, 1,   p‑MAPK↓, 1,   Mst1↓, 1,   mTOR↓, 1,   mTOR↑, 4,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 17,   PKA↑, 1,   PKCδ?, 1,   PKCδ↑, 4,   PP2A↑, 3,   PTEN↓, 4,   PTEN↑, 1,   RAS↓, 1,   STAT↓, 2,   STAT3↓, 5,   STAT3↑, 1,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   ATF4↓, 3,   ATF4↑, 1,   cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXO1↝, 1,   FOXO3↑, 2,   HDAC↓, 3,   HDAC2↓, 1,   OCT4↓, 1,   other?, 3,   other↓, 4,   other↑, 10,   other↝, 14,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   CHOP/DDIT3↑, 1,   ER Stress↓, 4,   GRP78/BiP↓, 3,   GRP78/BiP↑, 2,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 7,   HSPs↓, 1,   HSPs↑, 3,   IRE1↓, 1,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 2,   LC3II↓, 1,   LC3II↑, 2,   p62↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 16,   P53↓, 3,   P53↑, 1,   PARP↓, 1,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 1,   SIRT6↑, 1,   γH2AX↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CDK5↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   GADD34↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,   P21↓, 2,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FGF↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 2,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 2,   NOTCH1↑, 1,   p300↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 9,   Ca+2↝, 1,   Cartilage↑, 1,   COL1↓, 3,   COL1↑, 1,   COL3A1↓, 2,   E-cadherin↑, 1,   EMT↓, 1,   Fibronectin↓, 1,   heparanase↑, 1,   LRP1↑, 1,   MMP11↑, 1,   MMP13↓, 2,   MMP2↓, 5,   MMP2↑, 1,   MMP3↓, 1,   MMP3↑, 1,   MMP9↓, 12,   MMP9↑, 1,   MMPs↓, 2,   MUC1↑, 2,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   ROCK1↓, 2,   p‑SMAD2↓, 2,   SMAD3↓, 1,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   Smad7↑, 1,   TG2/TGase↓, 1,   TGF-β↓, 8,   TGF-β↑, 1,   TGF-β1↓, 1,   TGF-β1↑, 1,   TumCI↓, 1,   TXNIP↓, 3,   Vim↓, 2,   α-SMA↓, 9,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 2,   E-sel↓, 1,   eNOS↓, 1,   eNOS↑, 3,   p‑eNOS↑, 1,   Hif1a↓, 2,   Hif1a↑, 1,   LOX1↓, 1,   NO↓, 39,   NO↑, 4,   VCAM-1↓, 10,   VEGF↓, 2,   VEGF↑, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 37,   BBB↝, 1,   BBB∅, 2,   CLDN1↓, 1,   CLDN1↑, 1,   GastroP↑, 8,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 2,   GLUT4↑, 7,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 2,   MMP↑, 20,   MMP↝, 1,   NHE3↑, 1,   OATPs↓, 1,   OCLN↓, 1,   OCLN↑, 1,   TJ↑, 2,   TRPC1↓, 1,   TRPM7↓, 1,   ZO-1↓, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 1,   CD4+↑, 1,   CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 54,   COX2/PTGS2↑, 2,   HCAR2↑, 1,   HMGB1↓, 1,   ICAM-1↓, 8,   IFN-γ↓, 11,   IFN-γ↑, 1,   IL1↓, 4,   IL10↓, 11,   IL10↑, 12,   IL12↓, 3,   IL17↓, 5,   IL18↓, 2,   IL1β↓, 78,   IL1β↑, 1,   IL2↓, 4,   IL22↓, 1,   IL23↓, 2,   IL33↓, 1,   IL4↓, 7,   IL4↑, 4,   IL5↓, 2,   IL5↑, 1,   IL6↓, 67,   IL6↑, 4,   IL8↓, 9,   Imm↓, 1,   Imm↑, 8,   Imm⇅, 1,   INF-γ↓, 1,   Inflam↓, 163,   Inflam↑, 4,   IP-10/CXCL-10↓, 1,   IRF3↓, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 8,   MIP2↓, 1,   MyD88↓, 5,   NeuroI↓, 5,   NF-kB↓, 95,   NF-kB↑, 2,   NLRP3↓, 14,   p65↓, 4,   PGE2↓, 16,   PGE2↑, 1,   RAGE↓, 3,   RANTES↓, 1,   SOCS-3↓, 1,   TLR1↓, 1,   TLR2↓, 4,   TLR4↓, 21,   TNF-α↓, 103,   TNF-α↑, 3,   TRAF1↓, 1,   TRAF6↓, 1,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 9,   Ach↑, 10,   AChE↓, 46,   AChE↑, 1,   AChE∅, 1,   ADAM10↑, 3,   BChE↓, 10,   BDNF↓, 1,   BDNF↑, 28,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 7,   ChE↓, 1,   EndoR↑, 1,   GABA↑, 2,   MAOA↓, 5,   MAOB↓, 3,   monoA↑, 1,   NGF↑, 5,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 3,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 6,   Aβ↓, 44,   Aβ42↓, 4,   BACE/β-secretase↓, 17,   IDE↑, 1,   PSEN1/PS1↓, 1,   tau↓, 9,   p‑tau↓, 16,   XO↓, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   ER(estro)↑, 1,   FGF21↑, 2,   GR↑, 4,   GR↝, 1,   PPARα↑, 3,   PPARα↝, 1,   PPARγ↑, 8,   RAAS↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 36,   BioAv↑, 51,   BioAv⇅, 1,   BioAv↝, 22,   BioEnh↑, 3,   ChemoSen↑, 2,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 1,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 36,   eff↓, 8,   eff↑, 31,   eff↝, 2,   GSTA1↓, 1,   GSTA1↑, 2,   Half-Life↓, 6,   Half-Life↑, 5,   Half-Life↝, 8,   P-gp/ABCB1↓, 4,   P450↓, 3,   P450↑, 2,   P450↝, 1,   Synergy↑, 16,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 49,   ALAT↑, 1,   ALB↑, 1,   ALB↝, 1,   ALP↓, 12,   anemia↓, 1,   AST↓, 49,   AST↑, 1,   BG↓, 2,   Bil↓, 1,   BloodF↑, 1,   BMD↑, 2,   BP↓, 8,   BP↝, 1,   BUN?, 1,   BUN↓, 4,   CEA↓, 2,   CK/CK-MB↓, 1,   creat↓, 10,   CRP↓, 9,   Ferritin↓, 1,   Ferritin↑, 2,   HemoG↑, 1,   IL6↓, 67,   IL6↑, 4,   IRes↝, 1,   LDH↓, 15,   LDH↑, 1,   NOS2↓, 3,   RAGE↓, 3,   RBC↑, 1,   TG/TAG↓, 2,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 8,   antiAll?, 1,   antiAll↑, 11,   AntiArt↑, 10,   AntiCan↑, 17,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 26,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 1,   BOLD↑, 1,   cardioP?, 1,   cardioP↑, 59,   CardioT↓, 2,   chemoP↑, 14,   chemoPv↑, 3,   cognitive↓, 1,   cognitive↑, 66,   cognitive∅, 1,   diuretic↑, 1,   hepatoP↓, 2,   hepatoP↑, 82,   Learn↑, 7,   memory↑, 63,   Mood?, 1,   motorD↓, 1,   motorD↑, 9,   Mucositis↓, 1,   neuroP?, 1,   neuroP↑, 139,   NP/CIPN↓, 2,   Obesity↓, 11,   OS↑, 3,   Pain↓, 6,   radioP↑, 12,   RenoP↓, 1,   RenoP↑, 32,   RenoP↝, 1,   Risk↓, 4,   Sleep↑, 2,   Strength↑, 2,   Stress↓, 2,   Stroke↓, 12,   toxicity?, 2,   toxicity↓, 31,   toxicity↑, 3,   toxicity↝, 8,   toxicity∅, 11,   Weight↓, 3,   Weight↑, 1,   Weight∅, 2,   Wound Healing↓, 1,   Wound Healing↑, 9,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiBio↑, 9,   AntiFungal↑, 6,   AntiViral↑, 9,   Bacteria↓, 17,   Diar↓, 3,   GutMicro↑, 25,   Inf↓, 1,   Sepsis↓, 7,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 1,   Phen↑, 1,   QC↑, 1,  
Total Targets: 658

Scientific Paper Hit Count for: GSH, Glutathione
32 Thymoquinone
28 Curcumin
22 Silver-NanoParticles
21 Quercetin
20 Piperlongumine
19 Silymarin (Milk Thistle) silibinin
18 Alpha-Lipoic-Acid
17 Shikonin
15 Radiotherapy/Radiation
15 Luteolin
13 Sulforaphane (mainly Broccoli)
12 Resveratrol
12 Phenethyl isothiocyanate
11 Sulfasalazine
11 Lycopene
11 Selenite (Sodium)
10 Cisplatin
10 Allicin (mainly Garlic)
10 Artemisinin
10 Boron
10 Chrysin
10 Rosmarinic acid
9 Selenium
8 Melatonin
8 Chemotherapy
8 diet Methionine-Restricted Diet
8 Juglone
7 3-bromopyruvate
7 Ashwagandha(Withaferin A)
7 doxorubicin
7 Matrine
7 Propolis -bee glue
7 Selenium NanoParticles
6 Betulinic acid
6 Chlorogenic acid
6 Carvone
6 Copper and Cu NanoParticles
6 Eugenol
6 Gallic acid
6 Propyl gallate
5 Apigenin (mainly Parsley)
5 Baicalein
5 erastin
5 Rutin
5 Carvacrol
5 Crocetin
5 D-limonene
5 Ferulic acid
5 Hyperoside
5 Magnetic Fields
5 Vitamin C (Ascorbic Acid)
4 Berberine
4 Carnosic acid
4 Emodin
4 Fisetin
4 Honokiol
4 Kaempferol
4 Linalool
4 Morin
4 Parthenolide
3 2-DeoxyGlucose
3 Auranofin
3 chitosan
3 Cysteamine
3 Isoliquiritigenin
3 Licochalcone A
3 methylseleninic acid
3 Magnetic Field Rotating
3 Piperine
3 Pterostilbene
3 Aflavin-3,3′-digallate
3 Turmerones
2 Anethole/trans-Anethole
2 Ascorbyl Palmitate
2 Beta-Caryophyllene
2 Bromelain
2 brusatol
2 α-Bisabolol / Chamomile oil
2 buckwheat sprouts
2 Caffeic acid
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Gemcitabine (Gemzar)
2 Chocolate
2 Cichoric acid / Chicoric acid
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Date Fruit Extract
2 Docetaxel
2 Dandelion Root
2 Ellagic acid
2 EGCG (Epigallocatechin Gallate)
2 Sesame seeds and Oil
2 Formononetin
2 Fucoidan
2 Ginkgo biloba
2 Lemon Balm/Melissa officinalis
2 Geraniol
2 Ginger/6-Shogaol/Gingerol
2 Hydrogen Gas
2 Hibiscus sabdariffa
2 HydroxyTyrosol
2 isoorientin
2 Isovitexin
2 Lactoferrin/Talactoferrin
2 Methylsulfonylmethane
2 salinomycin
2 Vitexin
1 1,8-Cineole
1 cetuximab
1 Anthocyanins
1 Astragalus
1 Photodynamic Therapy
1 Camptothecin
1 Glucose
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Aloe anthraquinones
1 Baicalin
1 Ras-selective lethal 3
1 Boswellia (frankincense)
1 Butyrate
1 Capsaicin
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cat’s Claw
1 chemodynamic therapy
1 chaetocin
1 Chlorophyllin
1 Zinc
1 Chyawanprash
1 Cinnamon
1 Citric Acid
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Black phosphorus
1 SonoDynamic Therapy UltraSound
1 Cucurbitacin
1 Galantamine
1 Cynaropicrin
1 Diindolylmethane
1 Exercise
1 Shilajit/Fulvic Acid
1 Gambogic Acid
1 Garcinol
1 Salvia officinalis
1 Ginkgetin
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Hydroxycinnamic-acid
1 Hyperthermia
1 Isobavachalcone
1 Butein
1 Scopoletin
1 isoquercitrin
1 Lapatinib
1 Lapachol
1 Geldanamycin
1 Lemongrass Extract/Citral
1 SDG/lignans
1 Magnolol
1 Methyl Jasmonate
1 Metformin
1 Moringa oleifera
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Myricetin
1 N-Acetyl-Cysteine
1 Naringin
1 Nimbolide
1 Oleuropein
1 Marjoram (Origanum majorana)
1 Phenylbutyrate
1 Plumbagin
1 Orlistat
1 Scoulerine
1 polyethylene glycol
1 Anti-oxidants
1 Shankhpushpi
1 Squalene
1 Glutathione
1 Taurine
1 methotrexate
1 Ursolic acid
1 Urolithin
1 Vitamin B12
1 Folic Acid, Vit B9
1 VitK3,menadione
1 immunotherapy
1 Vitamin K2
1 probiotics
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:137  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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