| Source: |
| Type: type of cell death |
| Situation in which a cell actively pursues a course toward death upon receiving certain stimuli. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. |
| 9171- | BITC, | Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer through activation of p53-LKB1 and p73-LKB1 axes |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | MCF7 |
| 9181- | BITC, | Benzyl isothiocyanate suppresses development and metastasis of murine mammary carcinoma by regulating the Wnt/β-catenin pathway |
| - | vitro+vivo, | BC, | 4T1 |
| 9200- | BITC, | p53 Independent Apoptosis by Benzyl Isothiocyanate in Human Breast Cancer Cells Is Mediated by Suppression of XIAP Expression |
| - | vitro+vivo, | BC, | MCF7 | - | in-vitro, | BC, | MDA-MB-231 |
| 9169- | BITC, | CNOT2 /c-Myc/STAT3 signaling is critically involved in glycolysis mediated apoptosis of benzyl isothiocyanate in hepatocellular carcinoma |
| - | in-vitro, | adrenal, | SK-HEP-1 | - | in-vitro, | Liver, | HUH7 |
| 9168- | BITC, | Benzyl isothiocyanate suppresses development and metastasis of murine mammary carcinoma by regulating the Wnt/β‑catenin pathway |
| - | in-vitro, | BC, | 4T1 |
| 9165- | BITC, | Anticancer activities of dietary benzyl isothiocyanate: A comprehensive review |
| - | Review, | Var, | NA |
| 9163- | BITC, | Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells |
| - | in-vitro, | PC, | Capan1 |
| 9198- | BITC, | Benzyl Isothiocyanate–Mediated Inhibition of Histone Deacetylase Leads to NF-κB Turnoff in Human Pancreatic Carcinoma Cells |
| - | in-vitro, | PC, | Bxpc-3 | - | in-vitro, | PC, | Capan1 |
| 9185- | BITC, | PEITC, | AITC, | ITCs, | Effects of Brassicaceae Isothiocyanates on Prostate Cancer |
| - | Review, | Pca, | NA |
| 9161- | BITC, | Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | MCF7 | - | in-vitro, | NA, | MCF10 |
| 5688- | BJ, | Brucea Javanica Oil Emulsion Injection inhibits proliferation of pancreatic cancer via regulating apoptosis-related genes |
| - | vitro+vivo, | PC, | MIA PaCa-2 |
| 5687- | BJ, | Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways |
| - | vitro+vivo, | AML, | U937 |
| 5690- | BJ, | BRU, | Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica |
| - | Review, | Var, | NA |
| 5692- | BJ, | Seed oil of Brucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells |
| - | vitro+vivo, | AML, | NA |
| 5481- | BM, | Therapeutic potential of Bacopa monnieri extracts against hepatocellular carcinoma through in-vitro and computational studies |
| - | in-vitro, | HCC, | HepG2 |
| 5486- | BM, | Bacopaside I, acting as an aquaporin 1 inhibitor, ameliorates rheumatoid arthritis via suppressing aquaporin 1-mediated autophagy |
| - | in-vivo, | Arthritis, | NA |
| 5477- | BM, | The Aquaporin 1 Inhibitor Bacopaside II Reduces Endothelial Cell Migration and Tubulogenesis and Induces Apoptosis. |
| - | in-vitro, | Var, | NA |
| 5475- | BM, | The Purified Extract from the Medicinal Plant Bacopa monnieri, Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and Apoptosis |
| - | in-vitro, | Colon, | HT29 | - | in-vitro, | Colon, | SW48 | - | in-vitro, | Colon, | SW-620 | - | in-vitro, | CRC, | HCT116 |
| 5684- | BML, | Bromelain mediates apoptosis in HeLa cells via ROS-independent pathway |
| - | in-vitro, | Cerv, | HeLa |
| 5680- | BML, | Anticancer properties of bromelain: State-of-the-art and recent trends |
| - | Review, | Var, | NA |
| 5678- | BML, | Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy |
| - | in-vivo, | CRC, | NA |
| 5677- | BML, | Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis |
| - | in-vitro, | Melanoma, | A431 | - | in-vitro, | Melanoma, | A375 |
| 5651- | BNL, | Cisplatin, | Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway |
| - | in-vitro, | GBM, | U251 | - | in-vitro, | GBM, | U87MG |
| 5652- | BNL, | Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway |
| - | vitro+vivo, | GBM, | NA |
| 5653- | BNL, | Borneol hinders the proliferation and induces apoptosis through the suppression of reactive oxygen species-mediated JAK1 and STAT-3 signaling in human prostate cancer cells |
| - | in-vitro, | Pca, | PC3 |
| - | vitro+vivo, | GBM, | U251 |
| 5663- | BNL, | Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice |
| - | in-vivo, | AD, | NA |
| 5668- | BNL, | Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies |
| - | Review, | Var, | NA |
| 696- | Bor, | Nothing Boring About Boron |
| - | Review, | Var, | NA |
| 697- | Bor, | Boron-containing compounds as preventive and chemotherapeutic agents for cancer |
| - | Review, | Var, | NA |
| 740- | Bor, | Anti-cancer effect of boron derivatives on small-cell lung cancer |
| - | in-vitro, | Lung, | DMS114 | - | in-vitro, | Nor, | MRC-5 |
| 749- | Bor, | Comparative effects of boric acid and calcium fructoborate on breast cancer cells |
| - | in-vitro, | BC, | NA |
| 751- | Bor, | 5-FU, | Cytotoxic and Apoptotic Effects of the Combination of Borax (Sodium Tetraborate) and 5-Fluorouracil on DLD-1 Human Colorectal Adenocarcinoma Cell Line |
| - | in-vitro, | CRC, | DLD1 |
| 707- | Bor, | Cytotoxic and apoptotic effects of boron compounds on leukemia cell line |
| - | in-vitro, | AML, | HL-60 |
| 755- | Bor, | https://aacrjournals.org/cancerres/article/67/9_Supplement/4220/535557/Boric-acid-induces-apoptosis-in-both-prostate-and |
| - | in-vitro, | Pca, | DU145 | - | in-vitro, | PC, | PC3 |
| 766- | Bor, | In vitro effects of boric acid on human liver hepatoma cell line (HepG2) at the half-maximal inhibitory concentration |
| - | in-vitro, | Liver, | HepG2 |
| 716- | Bor, | Sugar-borate esters--potential chemical agents in prostate cancer chemoprevention |
| - | in-vitro, | Pca, | NA |
| 718- | Bor, | Boric Acid Exhibits Anticancer Properties in Human Endometrial Cancer Ishikawa Cells |
| - | in-vitro, | Endo, | NA |
| 719- | Bor, | Boric Acid Affects Cell Proliferation, Apoptosis, and Oxidative Stress in ALL Cells |
| - | in-vitro, | Var, | NA |
| 720- | Bor, | High Concentrations of Boric Acid Trigger Concentration-Dependent Oxidative Stress, Apoptotic Pathways and Morphological Alterations in DU-145 Human Prostate Cancer Cell Line |
| - | in-vitro, | Pca, | DU145 |
| 723- | Bor, | Boric acid suppresses cell proliferation by TNF signaling pathway mediated apoptosis in SW-480 human colon cancer line |
| - | in-vitro, | Colon, | SW480 |
| 722- | Bor, | Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms |
| - | in-vitro, | Ovarian, | MDAH-2774 |
| 725- | Bor, | Boric acid exert anti-cancer effect in poorly differentiated hepatocellular carcinoma cells via inhibition of AKT signaling pathway |
| - | in-vitro, | HCC, | NA |
| 724- | Bor, | Does Boric Acid Inhibit Cell Proliferation on MCF-7 and MDA-MB-231 Cells in Monolayer and Spheroid Cultures by Using Apoptosis Pathways? |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | MCF7 |
| 3507- | Bor, | Boron inhibits apoptosis in hyperapoptosis condition: Acts by stabilizing the mitochondrial membrane and inhibiting matrix remodeling |
| - | in-vivo, | Nor, | NA |
| 3510- | Bor, | Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks |
| - | in-vivo, | Nor, | NA |
| 4620- | Bor, | BTZ, | Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy |
| - | Review, | Var, | NA | - | Review, | Arthritis, | NA | - | Review, | Pca, | NA |
| 1424- | Bos, | Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells |
| - | in-vitro, | BC, | T47D | - | in-vitro, | BC, | MCF7 | - | in-vitro, | BC, | MDA-MB-231 |
| 1426- | Bos, | CUR, | Chemo, | Novel evidence for curcumin and boswellic acid induced chemoprevention through regulation of miR-34a and miR-27a in colorectal cancer |
| - | in-vivo, | CRC, | NA | - | in-vitro, | CRC, | HCT116 | - | in-vitro, | CRC, | RKO | - | in-vitro, | CRC, | SW480 | - | in-vitro, | RCC, | SW-620 | - | in-vitro, | RCC, | HT-29 | - | in-vitro, | CRC, | Caco-2 |
| 1448- | Bos, | A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells |
| - | in-vitro, | AML, | HL-60 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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