Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱
Source:
Type: type of cell death
Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.
Scientific Papers found: Click to Expand⟱
5658- BNL,    Natural borneol is a novel chemosensitizer that enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage
- vitro+vivo, GBM, U251
ChemoSen↑, mt-Apoptosis↑, Casp↑, DNAdam↑, ROS↑, angioG↓, BBB↑, EPR↑, TumVol↓, TumW↓, BioEnh↑,
5663- BNL,    Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice
- in-vivo, AD, NA
*ZO-1↓, *cl‑Casp3↓, *Bax:Bcl2↓, *MDA↓, *Apoptosis↓, *Aβ↓, *BACE↓, *cognitive↑, *BioAv↑, memory↑, P-gp↓, BioEnh↑,
5668- BNL,    Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies
- Review, Var, NA
AntiCan↑, Apoptosis↑, mtDam↑, ROS↑, mTORC1↓, EIF4E↓, Hif1a↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, ChemoSen↑, BioEnh↑, BioAv↑, BBB↑, toxicity↝,
3507- Bor,    Boron inhibits apoptosis in hyperapoptosis condition: Acts by stabilizing the mitochondrial membrane and inhibiting matrix remodeling
*MMP↑, *Cyt‑c↓, *Apoptosis↓, *Casp3↓, *NO↓, *iNOS↓,
3510- Bor,    Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *lipid-P↓, *GPx↓, *Catalase↑, *SOD↑, *ALAT↓, *AST↓, *ALP↓,
4620- Bor,  BTZ,    Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy
- Review, Var, NA - Review, Arthritis, NA - Review, Pca, NA
Risk↓, *memory↑, *Dose↑, Risk↓, other↝, *testos↑, other↝, Risk↓, TumCP↓, Apoptosis↑, eff↑,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
697- Bor,    Boron-containing compounds as preventive and chemotherapeutic agents for cancer
- Review, NA, NA
serineP↓, NADHdeh↓, Apoptosis↑,
740- Bor,    Anti-cancer effect of boron derivatives on small-cell lung cancer
- in-vitro, Lung, DMS114 - in-vitro, Nor, MRC-5
Apoptosis↑, TumCCA↑, P53↑, Casp3↑, *toxicity↓,
749- Bor,    Comparative effects of boric acid and calcium fructoborate on breast cancer cells
P53↓, Bcl-2↓, Casp3↑, Apoptosis↑,
751- Bor,  5-FU,    Cytotoxic and Apoptotic Effects of the Combination of Borax (Sodium Tetraborate) and 5-Fluorouracil on DLD-1 Human Colorectal Adenocarcinoma Cell Line
- in-vitro, CRC, DLD1
Apoptosis↑,
707- Bor,    Cytotoxic and apoptotic effects of boron compounds on leukemia cell line
- in-vitro, AML, HL-60
Apoptosis↑,
755- Bor,    https://aacrjournals.org/cancerres/article/67/9_Supplement/4220/535557/Boric-acid-induces-apoptosis-in-both-prostate-and
- in-vitro, Pca, DU145 - in-vitro, PC, PC3
TumCG↓, Apoptosis↑,
766- Bor,    In vitro effects of boric acid on human liver hepatoma cell line (HepG2) at the half-maximal inhibitory concentration
- in-vitro, Liver, HepG2
TumCCA↑, DNAdam↑, Apoptosis↑,
716- Bor,    Sugar-borate esters--potential chemical agents in prostate cancer chemoprevention
TumCG↓, Apoptosis↑,
718- Bor,    Boric Acid Exhibits Anticancer Properties in Human Endometrial Cancer Ishikawa Cells
- in-vitro, NA, NA
OSI↑, TNF-α↓, IL1↓, Casp3↑, Apoptosis↑, TOS↑,
719- Bor,    Boric Acid Affects Cell Proliferation, Apoptosis, and Oxidative Stress in ALL Cells
- in-vitro, Var, NA
Apoptosis↑, miR-21↓, TOS↓,
720- Bor,    High Concentrations of Boric Acid Trigger Concentration-Dependent Oxidative Stress, Apoptotic Pathways and Morphological Alterations in DU-145 Human Prostate Cancer Cell Line
- in-vitro, Pca, DU145
ROS↑, TumCG↓, Apoptosis↑,
723- Bor,    Boric acid suppresses cell proliferation by TNF signaling pathway mediated apoptosis in SW-480 human colon cancer line
- in-vitro, Colon, SW480
Apoptosis↑, TNF-α↝,
722- Bor,    Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms
- in-vitro, Ovarian, MDAH-2774
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, ROS↑, miR-21↓, miR-130a↓, Casp8∅, Casp10∅, cycD1/CCND1∅, CDK6∅, CDK4∅, FADD∅, DR4∅, DR5∅,
725- Bor,    Boric acid exert anti-cancer effect in poorly differentiated hepatocellular carcinoma cells via inhibition of AKT signaling pathway
- in-vitro, HCC, NA
tumCV↓, Apoptosis↑, TumAuto↑, p‑Akt↓,
724- Bor,    Does Boric Acid Inhibit Cell Proliferation on MCF-7 and MDA-MB-231 Cells in Monolayer and Spheroid Cultures by Using Apoptosis Pathways?
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
Apoptosis↑, Casp3↝, Casp8↝, Casp9↝,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
1424- Bos,    Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells
- in-vitro, BC, T47D - in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
tumCV↓, Apoptosis↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑,
1426- Bos,  CUR,  Chemo,    Novel evidence for curcumin and boswellic acid induced chemoprevention through regulation of miR-34a and miR-27a in colorectal cancer
- in-vivo, CRC, NA - in-vitro, CRC, HCT116 - in-vitro, CRC, RKO - in-vitro, CRC, SW480 - in-vitro, RCC, SW-620 - in-vitro, RCC, HT-29 - in-vitro, CRC, Caco-2
miR-34a↑, miR-27a-3p↓, TumCG↓, BAX↑, Bcl-2↓, PARP1↓, TumCCA↑, Apoptosis↑, cMyc↓, CDK4↓, CDK6↓, cycD1/CCND1↓, ChemoSen↑, miR-34a↑, miR-27a-3p↓,
1448- Bos,    A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells
- in-vitro, AML, HL-60
TumCP↓, Apoptosis↑, ROS↑, NO↑, cl‑Bcl-2↑, BAX↑, MMP↓, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, Casp↑, cl‑PARP↑, DR4↑, TNFR 1↑,
1449- Bos,  Chemo,    Anti-proliferative, Pro-apoptotic, and Chemosensitizing Potential of 3-Acetyl-11-keto-β-boswellic Acid (AKBA) Against Prostate Cancer Cells
- in-vitro, Pca, PC3
TumCP↓, ChemoSen↑, MMP↝, ROS↝, Apoptosis↑,
1450- Bos,  Cisplatin,    3-Acetyl-11-keto-β-boswellic acid (AKBA) induced antiproliferative effect by suppressing Notch signaling pathway and synergistic interaction with cisplatin against prostate cancer cells
- in-vitro, Pca, DU145
ROS↑, MMP↓, Casp↑, Apoptosis↑, Bax:Bcl2↑, TumCCA?, cycD1/CCND1↓, CDK4↓, P21↑, p27↑, NOTCH↓, ChemoSen↑,
5695- BRU,    Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
- in-vitro, Lung, A549
NRF2↓, ChemoSen↑, Apoptosis↑, TumCP↓, TumCG↓, MRP1/ABCC1↓, GSH↓, cMyc↓,
5691- BRU,    Brusatol Inhibits Proliferation, Migration, and Invasion of Nonsmall Cell Lung Cancer PC-9 Cells
- in-vitro, Lung, PC9 - in-vitro, Lung, H1975
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EGFR↓, β-catenin/ZEB1↓, Akt↓, STAT3↓, TumMeta↓, ChemoSen↑, NRF2↓, Akt↓, mTOR↓,
5707- Brut,    Targeting Redox Homeostasis and Cell Survival Signaling with a Flavonoid-Rich Extract of Bergamot Juice in In Vitro and In Vivo Colorectal Cancer Models
- in-vitro, CRC, HCT116
Risk↓, TumCG↓, Apoptosis↑, TumCCA↑, ROS↑, MMP↓, DNAdam↑, TumMeta↓, TumCP↓,
5706- Brut,    Bergamot juice extract inhibits proliferation by inducing apoptosis in human colon cancer cells
- in-vitro, CRC, HT29
TumCG↓, MAPK↓, TumCCA↑, Apoptosis↑, ROS↑, DNAdam↑, AntiCan↑,
5705- Brut,    A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
- in-vivo, CRC, NA
Risk↓, TumMeta↓, Apoptosis↑, COX2↓, iNOS↓, IL1β↓, IL6↓, IL10↓, P53↑, P21↓, survivin↓, chemoPv↑, *Inflam↓,
6547- BSB,    Antitumor effects of a-bisabolol against pancreatic cancer
- vitro+vivo, PC, PANC1 - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, KLM1 - in-vitro, PC, KP4 - in-vitro, Nor, ACBRI515
TumCP↓, selectivity↑, Apoptosis↑, Akt↓, EGR1↑, TumCG↓, Dose↝, PI3K↓, PDK1↓, mTORC2↑,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL6↑, *MMP13↓,
6543- BSB,    alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells
- in-vitro, GBM, U87MG
tumCV↓, selectivity↑, TumCD↑, Apoptosis↑, MOMP↓, Cyt‑c↑, cl‑PARP↑,
6544- BSB,    Involvement of mitochondrial permeability transition pore opening in alpha-bisabolol induced apoptosis
- in-vitro, GBM, NA
*Inflam↓, *AntiBio↑, selectivity↑, Apoptosis↑, Casp3↑, cl‑PARP↑, MMP↓, Cyt‑c↑, MPT↑, ROS↑, eff↓, OCR↓, eff↑,
6545- BSB,    The antineoplastic agent α-bisabolol promotes cell death by inducing pores in mitochondria and lysosomes
MPT↑, Casp↑, TumAuto↑, Apoptosis↑, TumCD↑, Dose↝, MMP↓, ROS↑, mtDam↑,
6546- BSB,    α-Bisabolol Inhibits Invasiveness and Motility in Pancreatic Cancer Through KISS1R Activation
- in-vitro, PC, NA
Apoptosis↑, TumCI↓, KISS1↑,
6548- BSB,    Anticancer effects of α-Bisabolol in human non-small cell lung carcinoma cells are mediated via apoptosis induction, cell cycle arrest, inhibition of cell migration and invasion and upregulation of P13K/AKT signalling pathway
- in-vitro, NSCLC, A549
AntiCan↑, Dose↝, TumCCA↑, mt-Apoptosis↑, TumCMig↓, PI3K↓, Akt↓,
6559- BSB,    Modulatory effect of α-Bisabolol on induced apoptosis via mitochondrial and NF-κB/Akt/PI3K Signaling pathways in MCF-7 breast cancer cells
- in-vitro, BC, MCF-7
TumCG↓, TumCP↓, Apoptosis↓, ROS↑, Bcl-2↓, BAX↑, BAD↑, Casp3↑, Casp9↑, Cyt‑c↑, NF-kB↓, p‑PI3K↓, p‑Akt↓,
6560- BSB,  doxoR,    Α-Bisabolol, a Component of German Chamomile Tea Attenuates NLRP3 Inflammasome Mediated Pyroptosis, NF-ΚB/MAPK Signaling Activation and Apoptosis by Invoking NRF2 Mediated Antioxidant Defense Systems in Doxorubicin-Induced Liver Injury in Rats
- in-vivo, Nor, NA
*lipid-P↓, *antiOx↑, *Apoptosis↓, *Inflam↓,
5745- Buty,    Microbial Oncotarget: Bacterial-Produced Butyrate, Chemoprevention and Warburg Effect
- Review, Var, NA
selectivity↑, HDAC↓, TumCP↓, Apoptosis↑, Warburg↓, chemoPv↑,
5739- Buty,    Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)
- Review, Var, NA
GutMicro↑, *Inflam↓, *IL6↓, *TNF-α↓, *IL17↓, *IL10↑, *ROS↝, COX2↓, NLRP3↓, Imm↑, HDAC↓, TumCCA↑, Apoptosis↑, ROS↑, Casp↑, mtDam↑, Cyt‑c↑, eff↑, chemoP↑, ChemoSen↑, eff↑, RadioS↑, HCAR2↑,
5732- Buty,    GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon
- Study, CRC, NA
HCAR2↑, other↓, Apoptosis↑, HDAC↓, Bcl-2↓, Bcl-xL↓, cycD1/CCND1↓, DR5↑, NF-kB↓, GutMicro↑, SLC12A5↝,
1207- CA,  PacT,    Caffeine inhibits the anticancer activity of paclitaxel via down-regulation of α-tubulin acetylation
- in-vitro, Lung, A549 - in-vitro, Cerv, HeLa
TumCG↑, TumCMig↓, Apoptosis↓, ac‑α-tubulin↑,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, eff↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, eff↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, eff↑, eff↑, eff↑,
1640- CA,  MET,    Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines
- in-vitro, Cerv, SiHa
GLS↓, NADPH↓, ROS↑, TumCD↑, AMPK↑, Hif1a↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDH↓, cMyc↓, BAX↓, cycD1/CCND1↓, PDH↓, ROS↑, Apoptosis↑, eff↑, ACLY↓, FASN↓, Bcl-2↓, Glycolysis↓,
1297- CA,    Caffeic Acid Phenethyl Ester (CAPE) Induced Apoptosis in Serous Ovarian Cancer OV7 Cells by Deregulation of BCL2/BAX Genes
- in-vitro, Ovarian, OV7
lysosome↓, Apoptosis↑, Bax:Bcl2↑,

Showing Research Papers: 351 to 400 of 1398
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1398

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   NADHdeh↓, 1,   NRF2↓, 2,   OSI↑, 1,   ROS↑, 16,   ROS↝, 1,   TOS↓, 1,   TOS↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   MMP↓, 5,   MMP↝, 1,   MPT↑, 2,   mtDam↑, 3,   OCR↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   AMPK↑, 2,   cMyc↓, 3,   FASN↓, 1,   GLS↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   LDH↓, 1,   NADPH↓, 1,   PDH↓, 1,   PDK1↓, 1,   PFK↓, 1,   PKM2↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 7,   p‑Akt↓, 2,   Apoptosis↓, 2,   Apoptosis↑, 42,   mt-Apoptosis↑, 2,   BAD↑, 1,   Bak↓, 1,   BAX↓, 1,   BAX↑, 5,   Bax:Bcl2↑, 3,   Bcl-2↓, 6,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 1,   BID↑, 1,   Casp↑, 8,   Casp10∅, 1,   Casp3↑, 6,   Casp3↝, 1,   Casp8↑, 1,   Casp8↝, 1,   Casp8∅, 1,   cl‑Casp8↑, 1,   Casp9↑, 2,   Casp9↝, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 7,   Diablo↑, 1,   DR4↑, 1,   DR4∅, 1,   DR5↑, 1,   DR5∅, 1,   FADD∅, 1,   Fas↑, 2,   ICAD↓, 1,   iNOS↓, 1,   JNK↑, 1,   MAPK↓, 2,   MAPK↑, 1,   MOMP↓, 1,   p27↑, 1,   survivin↓, 2,   TNFR 1↑, 1,   TumCD↑, 3,  

Kinase & Signal Transduction ⓘ

HCAR2↑, 2,   HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

KISS1↑, 1,   miR-21↓, 2,   miR-27a-3p↓, 2,   other↓, 1,   other↝, 2,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   lysosome↓, 1,   p62↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 5,   P53↓, 1,   P53↑, 5,   PARP↑, 1,   cl‑PARP↑, 5,   PARP1↓, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 2,   CDK4↑, 1,   CDK4∅, 1,   Cyc↓, 1,   cycD1/CCND1↓, 5,   cycD1/CCND1∅, 1,   P21↓, 1,   P21↑, 2,   RB1↑, 1,   TumCCA?, 1,   TumCCA↓, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EIF4E↓, 1,   EMT↓, 1,   ERK↓, 1,   ERK↑, 1,   FGF↓, 1,   HDAC↓, 4,   IGF-1↓, 1,   miR-34a↑, 2,   mTOR↓, 1,   mTORC1↓, 1,   mTORC2↑, 1,   NOTCH↓, 1,   PI3K↓, 4,   p‑PI3K↓, 1,   STAT3↓, 3,   TumCG↓, 10,   TumCG↑, 1,   Wnt↓, 1,  

Migration ⓘ

Ca+2↑, 1,   CEA↓, 1,   E-cadherin↑, 1,   miR-130a↓, 1,   MMP1↓, 1,   MMP2↓, 2,   MMP9↓, 3,   serineP↓, 1,   TIMP2↑, 1,   TSP-1↑, 1,   TumCI↓, 3,   TumCMig↓, 7,   TumCP↓, 11,   TumMeta↓, 5,   Vim↓, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   angioG↑, 1,   EGFR↓, 1,   EGFR↑, 1,   EGR1↑, 1,   EPR↑, 1,   HIF-1↓, 1,   Hif1a↓, 2,   NO↑, 1,   VEGF↓, 3,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

BBB↑, 2,   GLUT1↓, 1,   GLUT3↓, 1,   P-gp↓, 1,   SLC12A5↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 4,   CXCR4↓, 2,   HCAR2↑, 2,   IL1↓, 2,   IL10↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL4↓, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 1,   NF-kB↓, 6,   NF-kB↑, 1,   PSA↓, 1,   TNF-α↓, 2,   TNF-α↝, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,   CDK6↑, 1,   CDK6∅, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioEnh↑, 3,   ChemoSen↑, 11,   Dose↝, 3,   Dose∅, 1,   eff↓, 2,   eff↑, 11,   eff↝, 1,   MRP1/ABCC1↓, 1,   RadioS↑, 2,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

AR↓, 1,   CEA↓, 1,   EGFR↓, 1,   EGFR↑, 1,   GutMicro↑, 2,   HER2/EBBR2↓, 1,   IL6↓, 2,   LDH↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 5,   chemoP↑, 1,   chemoPv↑, 2,   memory↑, 1,   NDRG1↑, 1,   radioP↑, 1,   Risk↓, 6,   toxicity↝, 1,   TumVol↓, 2,   TumW↓, 1,  
Total Targets: 206

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

AntiBio↑, 3,  

Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 5,   GPx↓, 1,   GPx↑, 2,   GSH↑, 3,   HO-1↑, 2,   Keap1↑, 1,   lipid-P↓, 3,   MDA↓, 4,   NRF2↑, 3,   ROS↓, 4,   ROS↝, 1,   SAM-e↑, 1,   SOD↑, 6,   TBARS↓, 1,   uricA↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   ATP↝, 1,   MMP↑, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   LDH↑, 1,   NAD↝, 1,  

Cell Death ⓘ

Apoptosis↓, 5,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↑, 1,   Casp3↓, 2,   cl‑Casp3↓, 1,   Cyt‑c↓, 2,   iNOS↓, 3,  

Migration ⓘ

5LO↓, 1,   Ca+2↝, 1,   MMP13↓, 1,   serineP↓, 1,   ZO-1↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   GastroP↑, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   COX2↓, 3,   CRP↓, 1,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 1,   IL6↓, 3,   IL6↑, 1,   Imm↑, 2,   Inflam↓, 7,   TNF-α↓, 5,   VitD↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BChE↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,   BACE↓, 2,  

Hormonal & Nuclear Receptors ⓘ

testos↑, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 3,   Dose↑, 2,   Dose↝, 2,   eff↑, 3,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALP↓, 1,   AST↓, 2,   BMD↑, 1,   BMPs↑, 1,   Calcium↑, 1,   creat↓, 1,   CRP↓, 1,   hs-CRP↓, 1,   IL6↓, 3,   IL6↑, 1,   LDH↑, 1,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes ⓘ

cardioP↑, 2,   chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↓, 1,   cognitive↑, 3,   hepatoP↑, 1,   memory↑, 2,   motorD↑, 1,   neuroP↑, 4,   Pain↓, 1,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 2,  

Infection & Microbiome ⓘ

AntiFungal↑, 1,   CD8+↑, 1,  
Total Targets: 91

Scientific Paper Hit Count for: Apoptosis, Apoptosis
68 Curcumin
67 Silver-NanoParticles
43 Magnetic Fields
41 Quercetin
36 Thymoquinone
34 Berberine
31 Sulforaphane (mainly Broccoli)
31 EGCG (Epigallocatechin Gallate)
29 Baicalein
25 Ashwagandha(Withaferin A)
25 Capsaicin
25 Shikonin
23 Betulinic acid
23 Phenethyl isothiocyanate
22 Resveratrol
20 Radiotherapy/Radiation
19 Artemisinin
19 Apigenin (mainly Parsley)
19 Boron
19 Chrysin
19 Selenite (Sodium)
18 Dandelion Root
18 Honokiol
18 Lycopene
18 Urolithin
17 Garcinol
16 Eugenol
15 Chemotherapy
15 Carvacrol
15 Nimbolide
14 Cisplatin
14 Astaxanthin
14 chitosan
14 Crocetin
14 Luteolin
13 Beta-Caryophyllene
13 salinomycin
13 Magnolol
12 Allicin (mainly Garlic)
12 Graviola
12 Selenium NanoParticles
11 Propolis -bee glue
11 Silymarin (Milk Thistle) silibinin
11 Gambogic Acid
10 Copper and Cu NanoParticles
10 Vitamin C (Ascorbic Acid)
10 Alpha-Lipoic-Acid
10 Metformin
10 Chlorogenic acid
10 Phenylbutyrate
10 Piperlongumine
9 α-Bisabolol / Chamomile oil
9 Selenium
9 Cucurbitacin
9 Fisetin
9 Juglone
9 Rosmarinic acid
8 Photodynamic Therapy
8 5-fluorouracil
8 Coenzyme Q10
8 Auranofin
8 Paclitaxel
8 Bufalin/Huachansu
8 Citric Acid
8 Carvone
8 Electrical Pulses
8 Ursolic acid
8 Dichloroacetate
8 Magnetic Field Rotating
7 Gemcitabine (Gemzar)
7 Atorvastatin
7 doxorubicin
7 Biochanin A
7 borneol
7 Boswellia (frankincense)
7 Caffeic acid
7 Carnosic acid
7 Cinnamon
7 Emodin
7 HydroxyTyrosol
7 Vitamin K2
6 Astragalus
6 Andrographis
6 Celecoxib
6 D-limonene
6 Ellagic acid
6 Hydrogen Gas
6 Piperine
6 Parthenolide
6 Terpinen-4-ol / Tea Tree Oil
5 Anethole/trans-Anethole
5 immunotherapy
5 Melatonin
5 Thymol-Thymus vulgaris
5 Celastrol
5 Chlorophyllin
5 Aflavin-3,3′-digallate
5 Genistein (soy isoflavone)
5 Plumbagin
5 Pterostilbene
4 1,8-Cineole
4 3-bromopyruvate
4 Gold NanoParticles
4 Ascorbyl Palmitate
4 Berbamine
4 Brucea javanica
4 Bacopa monnieri
4 Bromelain
4 Butyrate
4 Disulfiram
4 Eurycomanone
4 Ferulic acid
4 Ginkgo biloba
4 Geraniol
4 γ-linolenic acid (Borage Oil)
4 Linalool
4 Spermidine
3 2-DeoxyGlucose
3 tamoxifen
3 Baicalin
3 brusatol
3 Bruteridin(bergamot juice)
3 Cat’s Claw
3 Cannabidiol
3 Cyclopamine
3 Date Fruit Extract
3 diet FMD Fasting Mimicking Diet
3 Fennel Oil/Foeniculum vulgare
3 Galloflavin
3 Orlistat
3 Hyperthermia
3 Methyl salicylate / Sweet Birch oil
3 Magnesium
3 Naringin
3 Niclosamide (Niclocide)
3 Sanguinarine
3 Psoralidin
3 α-Santalol/Sandalwood oil
3 Taurine
3 VitK3,menadione
3 Zerumbone
2 cetuximab
2 5-Aminolevulinic acid
2 Fenbendazole
2 Ajoene (compound of Garlic)
2 alpha Linolenic acid
2 DTS(dibenzyl trisulphide) from Anamu
2 Aspirin
2 Sorafenib (brand name Nexavar)
2 Dipyridamole
2 Aloe anthraquinones
2 beta-glucans
2 Docetaxel
2 Bortezomib
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Chocolate
2 irinotecan
2 CUSP9
2 Deguelin
2 diet Short Term Fasting
2 Folic Acid, Vit B9
2 Fucoidan
2 Shilajit/Fulvic Acid
2 Ginger/6-Shogaol/Gingerol
2 HydroxyCitric Acid
2 Methylglyoxal
2 Oleuropein
2 Oleocanthal
2 Oxygen, Hyperbaric
2 Propyl gallate
2 Rutin
2 Sulfasalazine
2 polyethylene glycol
2 Vitamin D3
1 5-Hydroxytryptophan
1 Glucose
1 entinostat
1 Trichostatin A
1 Radio Frequency
1 Acetyl-l-carnitine
1 Amodiaquine
1 temozolomide
1 Trastuzumab
1 almonertinib
1 epirubicin
1 Lapatinib
1 bempedoic acid
1 Bifidobacterium
1 Beta‐Lapachone
1 Selenate
1 Prebiotic
1 Choline
1 Hydroxycinnamic-acid
1 Vitamin E
1 Carica papaya leaf extract
1 Camptothecin
1 chemodynamic therapy
1 methylseleninic acid
1 Dichloroacetophenone(2,2-)
1 diet Methionine-Restricted Diet
1 Mistletoe
1 Lemongrass Extract/Citral
1 Evodiamine
1 Exercise
1 Gallic acid
1 carboplatin
1 gefitinib, erlotinib
1 Grapeseed extract
1 hydrogen sulfide
1 Rapamycin
1 Huperzine A/Huperzia serrata
1 Indole-3-carbinol
1 Inoscavin A
1 Ivermectin
1 Licorice
1 Lutein
1 Iron
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Mushroom Lion’s Mane
1 Myrrh
1 nicotinamide adenine dinucleotide
1 Proanthocyanidins
1 isoflavones
1 Vorinostat
1 Oxaliplatin
1 Scoulerine
1 acetazolamide
1 Osimertinib
1 Adagrasib
1 Glutathione
1 Tomatine
1 Turmerones
1 Docosahexaenoic Acid
1 Vitamin B3,Niacin
1 Whole Body Vibration
1 xanthohumol
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:14  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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