Synergy Cancer Research Results

Synergy, Synergy: Click to Expand ⟱
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Synergy — Interaction in which two or more agents, treatments, or biological interventions produce a combined effect greater than would be expected from their individual effects. In pharmacology and cancer research, synergy commonly refers to enhanced therapeutic efficacy when a compound is combined with chemotherapy, radiation, targeted therapy, or another bioactive agent.

Typical modulation in cancer: ↑ synergy is generally favorable when it increases tumor-cell killing, suppresses proliferation, enhances apoptosis or ferroptosis, or improves sensitivity to anticancer therapy. Synergy should be distinguished from simple additive effects and ideally supported by quantitative combination analysis such as combination index, Bliss independence, Loewe additivity, or related methods.

Typical modulation in Alzheimer’s disease: Context-dependent. Synergy may describe enhanced neuroprotective, anti-inflammatory, antioxidant, or cognitive effects produced by combinations of compounds or treatments, but it is not a disease-specific molecular pathway.
Scientific Papers found: Click to Expand⟱
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2/PTGS2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, Synergy↑, Synergy↑, Synergy↑,
3087- RES,    Resveratrol cytotoxicity is energy-dependent
- Review, Var, NA
OXPHOS↓, eff↝, Synergy↑,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
2991- RES,  Chemo,    Synergistic anti-cancer effects of resveratrol and chemotherapeutic agent clofarabine against human malignant mesothelioma MSTO-211H cells
- in-vitro, Melanoma, MSTO-211H - in-vitro, Nor, MeT5A
Synergy↑, selectivity↑, Sp1/3/4↓,
1391- RES,  BBR,    Effects of Resveratrol, Berberine and Their Combinations on Reactive Oxygen Species, Survival and Apoptosis in Human Squamous Carcinoma (SCC-25) Cells
- in-vitro, Tong, SCC25
ROS↑, Synergy↑,
3007- RosA,    Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action
- Review, NA, NA
*ROS↓, *lipid-P↓, *Inflam↓, *neuroP↑, *angioG↓, *Synergy↑, *AST↓, *ALAT↓, *GSSG↓, *eNOS↓, *iNOS↓, *NO↓, *NF-kB↓, *MMP2↓, *MDA↓, *TNF-α↓, *GSH↑, *SOD↑, *IL6↓, *PGE2↓, *COX2/PTGS2↓, *mTOR↑,
3002- RosA,    Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols
- Review, Var, NA
TumCG↓, TumCP↓, TumCCA↑, ChemoSen↑, NRF2↑, PERK↑, SESN2↑, HO-1↑, cl‑Casp3↑, ROS↑, UPR↑, ER Stress↑, CHOP/DDIT3↑, HER2/EBBR2↓, ER-α36↓, PSA↓, BAX↑, AR↓, P-gp/ABCB1↓, Cyt‑c↑, HSP70/HSPA5↑, eff↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, cl‑PARP↑, Synergy↑,
1747- RosA,    Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review
- Review, BC, MDA-MB-231 - Review, BC, MDA-MB-468
TumCCA↑, TNF-α↑, GADD45A↑, BNIP3↑, survivin↓, Bcl-2↓, BAX↑, HH↓, Synergy↑, ChemoSen↑, RadioS↑, TumCP↓, TumCMig↓, Apoptosis↑, RenoP↑, CardioT↓,
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp/ABCB1↓, Synergy↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,
1742- RosA,    Rosmarinic acid, a natural polyphenol, has a potential pro-oxidant risk via NADH-mediated oxidative DNA damage
- Analysis, Var, NA
ROS↑, Synergy↑, Synergy↑, eff↑, eff↑, eff↓, Dose↝, Dose↝,
4904- Sal,  CUR,    Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition
CSCs↓, TumCCA↑, EMT↓, other↝, TumAuto↑, Iron↑, Ferroptosis↑, BioAv↓, ROS↑, lipid-P↑, GPx4↓, Synergy↑,
4906- Sal,    A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022)
- Review, BC, NA
CSCs↓, Casp3↑, cl‑PARP↝, Apoptosis↑, ROS↑, ABC↓, OXPHOS↓, Glycolysis↓, Synergy↑, TumAuto↑, DNAdam↑, Wnt↓, Ferritin↓, Iron↑,
5036- SAS,    Targeting xCT with sulfasalazine suppresses triple-negative breast cancer growth via inducing autophagy and coordinating cell cycle and proliferation
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
xCT/SLC7A11↓, GSH↓, OS↑, Myc↓, CDK1↓, CD44↓, Synergy↑, TumCG↓,
4612- SeNPs,  Rad,    Histopathological Evaluation of Radioprotective Effects: Selenium Nanoparticles Protect Lung Tissue from Radiation Damage
- in-vivo, Nor, NA
*radioP↑, *Inflam↓, *antiOx↑, *Dose↝, *DNAdam↓, *ROS↓, *SOD↑, *GPx↑, *Dose↝, *Synergy↑,
4608- SeNPs,    Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics
- Review, Var, NA - NA, AD, NA
*toxicity↝, *toxicity↓, *other↝, ROS↑, *Dose↝, *selenoP↑, AntiCan↑, AntiTum↑, *Bacteria↓, *radioP↑, *BioAv↑, *Inflam↓, *Imm↑, ChemoSen↑, *AntiAg↑, selectivity↑, Synergy↑, other↝, *Synergy↑, *Aβ↓, *Synergy↑,
4603- SeNPs,    Therapeutic applications of selenium nanoparticles
- Review, Var, NA
AntiCan↑, Imm↑, *AntiDiabetic↑, *antiOx↑, *Inflam↓, ROS↑, ER Stress↑, DNAdam↑, *toxicity↓, *eff↑, *BioAv↑, selectivity↑, TumCCA↑, Risk↓, *lipid-P↓, *TNF-α↓, *CRP↓, TumMeta↓, angioG↓, selectivity↑, Synergy↑, *Synergy↑,
3198- SFN,    Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells
- in-vitro, Pca, NA
Nanog↓, SOX2↓, E-cadherin↓, Snail↓, VEGFR2/KDR/Flk1↓, Diff↓, TumCMig↓, EMT↓, CXCR4↓, NOTCH1↓, ALDH1A1↓, CSCs↓, Synergy↑,
1469- SFN,    Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vivo, Pca, NA
Synergy↑, ROS↑, MMP↓, Casp3↑, Casp9↑, DR4↑, DR5↑, BAX↑, Bak↑, BIM↑, NOXA↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, eff↓, TumCG↓, TumCP↓, eff↑, NF-kB↓, PI3K↓, Akt↓, MEK↓, ERK↓, angioG↓, FOXO3↑,
1465- SFN,    TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells
- NA, Bladder, NA
Synergy↑, Apoptosis↑, Casp↑, MMP↓, BID↑, DR5↑, ROS↑, NRF2↑, eff↑, eff↓,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, Synergy↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
1478- SFN,  acet,    Anti-inflammatory and anti-oxidant effects of combination between sulforaphane and acetaminophen in LPS-stimulated RAW 264.7 macrophage cells
- in-vitro, Nor, NA
Synergy↑, NO↓, iNOS↓, COX2/PTGS2↓, IL1β↓, ROS↓,
1476- SFN,  PDT,    Enhancement of cytotoxic effect on human head and neck cancer cells by combination of photodynamic therapy and sulforaphane
- in-vitro, HNSCC, NA
Synergy↑, tumCV↓, ROS↑, eff↓, Casp↑,
1475- SFN,  Form,    Combination of Formononetin and Sulforaphane Natural Drug Repress the Proliferation of Cervical Cancer Cells via Impeding PI3K/AKT/mTOR Pathway
- in-vitro, Cerv, HeLa
TumCP↓, PI3K↓, Akt↓, mTOR↓, Synergy↑, ROS↑,
1513- SFN,  acetaz,    Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis
- in-vitro, BrCC, H720 - in-vivo, BrCC, NA - in-vitro, BrCC, H727
Synergy↑, tumCV↓, Apoptosis↑, P21↑, PI3K↓, Akt↓, mTOR↓, 5HT↓, NRF2↑,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,
3307- SIL,    Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications
- Review, Var, NA
*NRF2↑, *antiOx↑, *chemoP↑, *Inflam↓, *BioAv↑, Synergy↑, *NQO1↑, TNF-α↓, IL6↓, *GSH↑, *ROS↓, *MDA↓, Synergy↑, *hepatoP↑, *GPx↑, *SOD↑, *Catalase↑, *HO-1↑, *neuroP↑,
3294- SIL,    Silymarin: a review on paving the way towards promising pharmacological agent
- Review, Nor, NA - Review, Arthritis, NA
*hepatoP↑, *Inflam↓, *chemoP↑, *glucose↓, *antiOx↑, *ROS↓, *ACC↓, *FASN↓, *radioP↑, *NF-kB↓, *TGF-β↓, *AST↓, *α-SMA↝, *Synergy↑, *neuroP↑, Synergy↑, ROS↓,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, Synergy↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, Synergy↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,
2009- SK,    Necroptosis inhibits autophagy by regulating the formation of RIP3/p62/Keap1 complex in shikonin-induced ROS dependent cell death of human bladder cancer
- in-vitro, Bladder, NA
TumCG↓, selectivity↑, *toxicity∅, Necroptosis↑, ROS↑, p62↑, Keap1↑, *NRF2↑, Synergy↑,
5103- SK,    Attenuation of PI3K-Akt-mTOR Pathway to Reduce Cancer Stemness on Chemoresistant Lung Cancer Cells by Shikonin and Synergy with BEZ235 Inhibitor
- in-vitro, NSCLC, A549
CSCs↓, TumCP↓, Nanog↓, OCT4↓, p‑Akt↓, P70S6K↓, PI3K↓, mTOR↓, Synergy↑,
4892- Sper,  erastin,    Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer
- in-vitro, Pca, PC3 - in-vivo, Pca, NA
Ferroptosis↑, lipid-P↑, Iron↑, Synergy↑, HO-1↑, NRF2↑, ROS↑, AntiTum↑, eff↓,
1706- SSE,    Selenium in Prostate Cancer: Prevention, Progression, and Treatment
- Review, Pca, NA
Risk∅, ChemoSen↑, Risk↓, toxicity↝, Risk↑, Synergy↑, *toxicity↑, RadioS↑, eff↓, eff↑, ChemoSen↑, ChemoSideEff↓,
1688- SSE,    Potential Role of Selenium in the Treatment of Cancer and Viral Infections
- Review, Var, NA
IL2↑, INF-γ↑, Th1 response↑, Th2↑, Dose↑, AntiCan∅, Risk↑, chemoP↑, Hif1a↓, VEGF↓, selectivity↑, *GADD45A↑, NRF2↓, *NRF2↑, ChemoSen↑, angioG↓, PrxI↓, ChemoSideEff↓, Synergy↑,
1575- statins,  Citrate,    Inhibition of Lung Cancer Growth: ATP Citrate Lyase Knockdown and Statin Treatment Leads to Dual Blockade of Mitogen-Activated Protein Kinase (MAPK) and Phosphatidylinositol-3-Kinase (PI3K)/AKT Pathways
- in-vitro, NSCLC, A549
Synergy↑, HMG-CoA↓, eff↑, AntiTum↑, EGFR↓, eff↑, ROS↑, EMT↓, E-cadherin↑, MUC1↑, p‑ACLY↓, p‑Akt↓, eff↑,
6435- T4O,    Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models
- NA, Melanoma, NA
selectivity↑, Apoptosis↑, Synergy↑, ChemoSen↑, BioAv↝,
6433- T4O,  CET,    Terpinen-4-ol: A Novel and Promising Therapeutic Agent for Human Gastrointestinal Cancers
- in-vitro, Colon, HT29 - in-vitro, CRC, HCT116 - in-vitro, PC, COLO357 - Human, Colon, NA
TumCG↓, Synergy↑, ChemoSen↑, Apoptosis↑, TumVol↓, TumW↓, *Inflam↓, *antiOx↓, BioAv↝,
2353- TQ,    The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies
- Review, PC, NA
BioAv↝, BioAv↑, MUC4↓, PKM2↓, Synergy↑, TumVol↓, HDAC↓, NF-kB↓, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, COX2/PTGS2↓, PGE1↓,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, Synergy↑, DNAdam↑, *iNOS↓,
3408- TQ,    Thymoquinone: A small molecule from nature with high therapeutic potential
- Review, AD, NA - Review, Park, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *Inflam↓, *antiOx↑, ChemoSen↑, Synergy↑, Synergy↑, TumCP↓, TumCCA↑, angioG↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, BioAv↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
2123- TQ,    Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma
- in-vitro, lymphoma, PEL
Akt↓, ROS↑, BAX↓, MMP↓, Cyt‑c↑, Synergy↑, Casp9↑, Casp3↑, cl‑PARP↑, DR5↑,
2127- TQ,    Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
- Review, GBM, NA
chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2/PTGS2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, Synergy↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,
2454- Trip,    Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
- in-vitro, HNSCC, HaCaT - in-vivo, NA, NA
GSDME-N↑, Pyro↑, cMyc↓, HK2↓, BAD↑, BAX↑, Casp3↑, NRF2↓, xCT/SLC7A11↓, ROS↑, Synergy↑, Glycolysis↓, GlucoseCon↓, lactateProd↓, ATP↓, xCT/SLC7A11↓, eff↑,
6459- TUR,    Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis
- in-vivo, Nor, NA - in-vivo, Colon, NA
*NO?, eff↑, Synergy↑, AntiTum↑, *Inflam↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *Synergy↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4876- Uro,    Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management
- Review, Park, NA - Review, AD, NA
*Inflam↓, *antiOx↓, *neuroP↑, *p‑tau↓, *Aβ↓, *Synergy↑, *BioAv↓, *BioAv↑, *GSH↑, *SOD↑, *lipid-P↓, *Catalase↑, *GSR↑, *GPx↑, *ROS↓, *NRF2↑, *GutMicro↑, *Risk↓, *BBB↓, *NLRP3↓, *MAOA↓,
4842- Uro,    Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vitro, BC, MCF7 - in-vitro, BC, 4T1
Inflam↓, IL6↓, TNF-α↓, Synergy↑, STAT3↓, TumCP↓, TumCMig↓,
6412- Uro,  EGCG,    A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer’s Disease
- in-vivo, AD, NA
*Aβ↓, *Synergy↑, *cognitive↑, *neuroG↑, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *p‑tau↓, *FIS1↓, *ATP↑, *lipid-P↓,
3140- VitC,    Vitamin-C-dependent downregulation of the citrate metabolism pathway potentiates pancreatic ductal adenocarcinoma growth arrest
- in-vitro, PC, MIA PaCa-2 - in-vitro, Nor, HEK293
citrate↓, FASN↓, ACLY↓, LDH↓, Glycolysis↓, Warburg↓, PDK1 / PDPK1↓, GLUT1↓, LDHA↓, ECAR↓, PDH↑, Synergy↑,

Showing Research Papers: 351 to 400 of 416
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 416

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

APE1/APEX1↓, 1,   AURKB↓, 1,   CBR1↓, 1,   CD47↓, 1,   CLDN7↑, 1,   compV↓, 1,   ERCC3↑, 1,   H3K9↓, 3,   IRes↓, 1,   KAI1/CD82↑, 1,   miR-107↑, 1,   miR-124-3p↓, 1,   miR-224↓, 1,   miR-375↑, 1,   miR-422a↑, 1,   MMP16↓, 1,   MYCN↑, 1,   NA↑, 2,   OGFr↑, 1,   OLIG2↓, 1,   ORR↑, 1,   PFS↓, 1,   PFS↑, 1,   PLA2↓, 1,   PSEN1/PS1↓, 1,   PTN↓, 1,   RBC↑, 1,   SUV39H↓, 3,   XRCC1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 6,   antiOx⇅, 1,   ATF3↑, 1,   Catalase↓, 3,   Catalase↑, 2,   compI↓, 2,   CYP1A1↑, 1,   Fenton↑, 5,   Ferroptosis↓, 1,   Ferroptosis↑, 15,   frataxin↑, 1,   GPx↓, 3,   GPx↑, 2,   GPx4↓, 5,   GPx4↑, 1,   GSH↓, 21,   GSH↑, 1,   GSH↝, 1,   GSR↑, 1,   GSSG↑, 1,   GSTP1/GSTπ↓, 2,   GSTs↓, 1,   GSTZ1↓, 1,   H2O2↑, 5,   HK1↓, 1,   HO-1↓, 3,   HO-1↑, 10,   hyperG↓, 1,   ICD↑, 2,   Iron↑, 5,   i-Iron↑, 2,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 10,   MDA↓, 1,   MDA↑, 4,   Mets↑, 1,   MFN2↑, 1,   NQO1↑, 3,   NRF2↓, 10,   NRF2↑, 13,   OXPHOS↓, 6,   OXPHOS↑, 4,   OXPHOS↝, 2,   PARK2↑, 1,   PrxI↓, 1,   PYCR1↓, 1,   ROS?, 2,   ROS↓, 18,   ROS↑, 175,   ROS⇅, 3,   i-ROS↑, 1,   mt-ROS↑, 3,   SIRT3↓, 1,   SIRT3↑, 2,   SOD↓, 4,   SOD↑, 3,   Trx↓, 3,   Trx1↓, 1,   Trx2↓, 1,   TrxR↓, 4,   TrxR1?, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 5,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 1,   KLF5↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   AIF↑, 2,   ATP↓, 14,   ATP↑, 1,   mt-ATP↓, 1,   BCR-ABL↓, 1,   CDC2↓, 3,   CDC25↓, 1,   compIII↓, 1,   EGF↓, 2,   ETC↓, 1,   ETC↑, 1,   ETC↝, 1,   FGFR1↓, 1,   Insulin↓, 2,   MEK↓, 5,   mitResp↓, 1,   mitResp↑, 3,   MMP↓, 57,   MMP↑, 3,   Mortalin↓, 1,   MPT↑, 4,   mtDam↑, 10,   OCR↓, 2,   OCR↑, 2,   PGC-1α↑, 1,   PINK1↑, 1,   Raf↓, 2,   c-Raf↓, 1,   SDH↓, 1,   XIAP↓, 12,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 3,   ACLY↓, 4,   p‑ACLY↓, 1,   ACSL4↑, 2,   adiP↑, 1,   ALAT↓, 4,   ALAT↑, 1,   AMP↑, 1,   AMPK↑, 17,   ATG7↑, 2,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   citrate↓, 2,   cMyc↓, 23,   CPT1A↓, 1,   CYP3A4↓, 1,   ECAR↓, 1,   FASN↓, 4,   FASN↑, 1,   FGF21↓, 1,   glucoNG↓, 1,   glucose↓, 1,   glucose↝, 1,   GlucoseCon↓, 6,   GlucoseCon↑, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 33,   Glycolysis↑, 1,   Histones↝, 1,   HK2↓, 16,   HMG-CoA↓, 9,   KeyT↑, 1,   lactateProd↓, 11,   lactateProd↑, 1,   LDH↓, 10,   p‑LDH↓, 1,   LDHA↓, 6,   LDL↓, 3,   lipoGen↓, 2,   NADH:NAD↓, 1,   NADPH↓, 4,   NADPH↑, 2,   PDH↓, 1,   PDH↑, 5,   p‑PDH↑, 1,   PDHB↓, 1,   PDK1 / PDPK1↓, 8,   PDK3↑, 1,   PDKs↓, 10,   PFK↓, 2,   PFK2?, 1,   PFKFB2↓, 1,   PI3K/Akt↓, 1,   PKM2↓, 11,   PKM2↑, 1,   POLD1↓, 1,   PPARα↓, 2,   PPARγ↓, 1,   PPARγ↑, 3,   p‑S6K↓, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 4,   SIRT2↓, 2,   SREBP2↓, 2,   STK11/LKB1↑, 1,   TCA↓, 2,   TCA↑, 1,   TS↓, 1,   Warburg↓, 10,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis?, 2,   Apoptosis↓, 4,   Apoptosis↑, 119,   ASK1↑, 1,   BAD↑, 4,   BAD↝, 1,   Bak↑, 4,   BAX↓, 3,   BAX↑, 59,   BAX↝, 2,   Bax:Bcl2↑, 16,   Bcl-2↓, 67,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-xL↓, 15,   Bcl-xL↑, 1,   BID↑, 1,   BIM↑, 6,   Casp↑, 18,   Casp1↑, 1,   Casp12?, 1,   Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 3,   Casp3↑, 77,   cl‑Casp3↑, 11,   cl‑Casp3⇅, 1,   proCasp3↑, 2,   pro‑Casp3↑, 1,   Casp7↑, 6,   cl‑Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 8,   cl‑Casp8↑, 2,   proCasp8↑, 2,   pro‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 42,   cl‑Casp9↑, 6,   proCasp9↑, 2,   cFLIP↓, 2,   Chk2↓, 1,   CK2↓, 4,   Cupro↑, 1,   Cyt‑c↑, 35,   Diablo↑, 4,   DR4↑, 5,   DR5↑, 14,   FADD↑, 2,   Fas↑, 10,   FasL↑, 2,   Ferroptosis↓, 1,   Ferroptosis↑, 15,   GSDME-N↑, 1,   HEY1↓, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 10,   IAP1↓, 3,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 6,   iNOS↑, 2,   JNK↓, 3,   JNK↑, 9,   p‑JNK↓, 3,   p‑JNK↑, 1,   MAPK↓, 8,   MAPK↑, 5,   MAPK↝, 1,   p‑MAPK↓, 1,   Mcl-1↓, 16,   Mcl-1↑, 1,   MDM2↓, 3,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↑, 2,   Myc↓, 4,   Myc↑, 1,   Necroptosis↑, 3,   necrosis↑, 2,   NOXA↑, 1,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 7,   p38↓, 2,   p38↑, 5,   p‑p38↓, 1,   p‑p38↑, 2,   Paraptosis↑, 2,   Proteasome?, 1,   Proteasome↓, 3,   PUMA↑, 3,   Pyro↑, 3,   survivin↓, 24,   Telomerase↓, 6,   TRAIL↑, 1,   TRPV1↑, 1,   TumCD↓, 2,   TumCD↑, 18,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 67,   Akt↑, 11,   p‑Akt↓, 17,   Akt2↓, 1,   AMPKα↑, 1,   cSrc↓, 1,   EF-1α↓, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 7,   miR-25-5p↓, 1,   p70S6↓, 1,   SOX9?, 1,   SOX9↓, 1,   Sp1/3/4↓, 7,   TRPV2↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↝, 1,   cJun↓, 7,   cJun↑, 3,   EZH2↓, 3,   H3↑, 2,   ac‑H3↑, 3,   H3K4↓, 1,   H4↑, 1,   ac‑H4↑, 3,   HATs↓, 3,   HATs↑, 1,   miR-21↓, 2,   miR-27a-3p↓, 1,   other↓, 5,   other↑, 9,   other↝, 11,   PCAF↓, 1,   PhotoS↑, 3,   pRB↓, 1,   p‑pRB↓, 2,   sonoS↑, 2,   tumCV?, 1,   tumCV↓, 31,   tumCV↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 9,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 2,   p‑eIF2α↑, 2,   ER Stress↑, 34,   GRP78/BiP↓, 2,   GRP78/BiP↑, 9,   GRP78/BiP↝, 1,   GRP94↑, 1,   HSP27↓, 4,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 4,   HSP72↑, 1,   HSP90↓, 9,   HSPs↓, 1,   HSPs↑, 1,   IRE1↑, 3,   PERK↑, 4,   UPR↑, 9,   XBP-1↓, 1,   XBP-1↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 2,   autoF↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 8,   p‑Beclin-1/ATG6↑, 1,   BNIP3↑, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 2,   LC3II↓, 1,   LC3II↑, 9,   LC3s↓, 1,   lysosome↓, 1,   MitoP↑, 1,   p62↓, 5,   p62↑, 6,   SESN2↑, 1,   TumAuto↑, 32,   TumAuto⇅, 2,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   CHK1↓, 2,   p‑CHK1↑, 1,   DNA-PK↑, 2,   DNAdam↑, 38,   DNArepair↓, 2,   DNArepair↑, 1,   DNMT1↓, 7,   DNMT3A↓, 2,   DNMT3B↓, 1,   DNMTs↓, 5,   m-FAM72A↓, 1,   GADD45A↑, 1,   MGMT↓, 1,   p16↑, 1,   P53↓, 2,   P53↑, 36,   p‑P53↓, 1,   p‑P53↑, 3,   PARP↑, 9,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 35,   cl‑PARP↝, 1,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 13,   SIRT6↓, 1,   TP53↓, 2,   TP53↑, 3,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 9,   CDK2↓, 20,   CDK4↓, 27,   CDK4↑, 3,   Cyc↓, 2,   cycA1/CCNA1↓, 5,   CycB/CCNB1↓, 12,   cycD1/CCND1↓, 41,   CycD3↓, 3,   cycE/CCNE↓, 13,   cycE1↓, 1,   E2Fs↓, 2,   mitA↑, 1,   P21?, 2,   P21↓, 3,   P21↑, 21,   RB1↑, 1,   p‑RB1↓, 3,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 4,   TumCCA↑, 87,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 5,   ALDH1A1↓, 1,   CD133↓, 3,   CD133↑, 1,   CD24↓, 1,   CD44↓, 7,   cFos↓, 7,   cMYB↓, 2,   CSCs↓, 35,   CSCsMark↓, 1,   CTSB↓, 1,   CTSD↓, 1,   CTSL↑, 1,   Diff↓, 3,   Diff↑, 6,   EMT↓, 47,   EMT↑, 2,   ERK↓, 13,   ERK↑, 5,   ERK↝, 1,   p‑ERK↓, 11,   FGF↓, 1,   FOXM1↓, 3,   FOXO↑, 1,   FOXO1↓, 2,   FOXO3↓, 1,   FOXO3↑, 7,   FOXO4↓, 1,   FOXO4↑, 1,   Gli↓, 1,   Gli1↓, 4,   GSK‐3β↓, 4,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 2,   p‑GSK‐3β↑, 1,   HDAC↓, 19,   HDAC1↓, 2,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC8↓, 1,   HH↓, 6,   HMGCR↓, 1,   HMGCR↑, 1,   HMGCR⇅, 1,   HMTs↓, 1,   IGF-1?, 1,   IGF-1↓, 6,   IGF-1R↓, 3,   IGF-1R↑, 1,   IGFBP1↑, 2,   IGFBP3↑, 1,   KLF4↓, 1,   Let-7↑, 2,   LRP6↓, 1,   p‑MAP2K1/MEK1↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   mTOR↓, 41,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 3,   mTORC1↓, 4,   p‑mTORC1↓, 1,   mTORC2↓, 1,   n-MYC↓, 2,   Nanog↓, 9,   Nestin↓, 3,   NOTCH↓, 6,   NOTCH↑, 1,   NOTCH1↓, 8,   NOTCH1↑, 4,   NOTCH3↓, 3,   OCT4↓, 7,   p300↓, 1,   P70S6K↓, 3,   p‑P70S6K↓, 2,   P90RSK↓, 1,   PI3K↓, 51,   PI3K↑, 4,   p‑PI3K↓, 3,   PTCH1↓, 2,   PTCH2↓, 1,   PTEN↑, 11,   RAS↓, 6,   SAL↑, 1,   Shh↓, 3,   SHP1↑, 2,   Smo↓, 1,   SOX2↓, 4,   Src↓, 1,   STAT↓, 2,   STAT3↓, 41,   STAT3↝, 1,   p‑STAT3↓, 9,   p‑STAT3↑, 4,   STAT4↓, 1,   STAT5↓, 1,   STAT6↓, 2,   TCF↓, 1,   TCF↑, 1,   TCF-4↓, 1,   TOP1↓, 5,   TOP2↓, 2,   TOP2↑, 1,   TRPM7↓, 1,   TumCG↓, 71,   TumCG↑, 2,   tyrosinase↓, 1,   Wnt↓, 22,   Wnt↑, 2,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 5,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 5,   AXL↓, 1,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 13,   CAFs/TAFs↓, 1,   cal2↑, 1,   CC(CDKs/cyclins)↓, 1,   CD11b↑, 2,   CDKN1C/p57↑, 1,   CLDN1↓, 3,   CLDN2↓, 1,   CLDN2↑, 1,   Cofilin↓, 1,   CXCL12↓, 2,   E-cadherin↓, 4,   E-cadherin↑, 25,   ER-α36↓, 2,   FAK↓, 5,   p‑FAK↓, 2,   fascin↓, 2,   Fibronectin↓, 5,   GLI2↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   ITGB4↓, 1,   Ki-67↓, 17,   Ki-67↑, 1,   KLF2↓, 1,   KRAS↓, 2,   L-sel↑, 1,   LAMs↓, 2,   MALAT1↓, 3,   MET↓, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-29b↓, 1,   miR-340↓, 1,   miR-384↑, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP13↓, 1,   MMP15↓, 1,   MMP2↓, 40,   MMP2↑, 1,   MMP3↓, 2,   MMP7↓, 6,   MMP9↓, 49,   MMP9↑, 2,   MMPs↓, 19,   MUC1↑, 1,   MUC4↓, 1,   N-cadherin↓, 16,   PAK1↓, 1,   PDGF↓, 2,   PKA↓, 1,   PKA↑, 1,   PKCδ↓, 5,   RECK↑, 1,   Rho↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   ROCK1↓, 3,   Slug↓, 9,   Smad1↓, 2,   SMAD2↓, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 13,   SOX4↓, 2,   STAC2↓, 1,   TET1↑, 4,   TGF-β↓, 11,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 4,   Treg lymp↓, 2,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 51,   TumCMig↓, 36,   TumCMig↑, 1,   TumCP?, 1,   TumCP↓, 69,   TumCP↑, 2,   TumMeta↓, 36,   TumMeta↑, 2,   Twist↓, 7,   uPA↓, 9,   uPAR↓, 1,   VEGFR1↓, 1,   Vim?, 1,   Vim↓, 19,   Zeb1↓, 10,   Zeb1↑, 1,   ZEB2↓, 2,   ZO-1↑, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 28,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 53,   angioG↑, 2,   ATF4↓, 1,   ATF4↑, 7,   ECM/TCF↓, 1,   EGFR↓, 19,   eNOS↓, 2,   eNOS↑, 1,   EPR↓, 1,   EPR↑, 1,   HIF-1↓, 4,   Hif1a↓, 34,   Hif1a↑, 1,   Hypoxia↓, 1,   miR-126↑, 1,   NO↓, 4,   NO↑, 2,   PDGFR-BB↓, 2,   p‑PDGFR-BB↓, 1,   VEGF↓, 58,   VEGFR2/KDR/Flk1↓, 7,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   BBB∅, 1,   CellMemb↑, 1,   GLUT1↓, 6,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   P-gp/ABCB1↓, 10,   P-gp/ABCB1↝, 1,   P-gp/ABCB1∅, 1,   SMCT1∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 45,   COX2/PTGS2↑, 3,   CRP↓, 2,   CXCR4↓, 9,   FOXP3↓, 1,   HCAR2↑, 1,   HMGB1↓, 3,   IFN-γ↓, 1,   IFN-γ↑, 3,   IKKα↓, 3,   IL1↓, 1,   IL10↓, 4,   IL10↑, 1,   IL12↓, 1,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 9,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 4,   IL4↓, 2,   IL4↑, 1,   IL6↓, 21,   IL8↓, 5,   Imm↑, 16,   Imm↝, 3,   INF-γ↑, 1,   Inflam↓, 19,   IκB↑, 1,   JAK↓, 3,   JAK1↓, 2,   JAK2↓, 7,   M2 MC↓, 3,   MCP1/CCL2↓, 4,   MIP2↓, 1,   MyD88↑, 1,   NF-kB↓, 65,   NF-kB↑, 4,   NF-kB↝, 1,   p‑NF-kB↓, 1,   NK cell↑, 9,   p65↓, 4,   ac‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 6,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 19,   PSA↓, 5,   PSA∅, 1,   T-Cell↑, 2,   T-Cell↝, 1,   Th1 response↑, 3,   Th2↑, 1,   TLR4↓, 2,   TLR4↑, 1,   TNF-α↓, 15,   TNF-α↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 2,   pH↑, 1,   e-pH↑, 4,   i-pH↓, 1,   TIM-3↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,   PP2A↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 10,   CDK6↓, 8,   CDK6↑, 4,   COMT↓, 2,   CYP19↓, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↑, 1,   GR↑, 1,   RANKL↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 19,   BioAv↑, 33,   BioAv↝, 13,   BioEnh↑, 1,   chemoR↓, 1,   ChemoSen↓, 3,   ChemoSen↑, 137,   ChemoSen⇅, 2,   CYP1A2↓, 1,   CYP2C9↓, 1,   DDS↑, 1,   Dose?, 1,   Dose↓, 5,   Dose↑, 9,   Dose↝, 50,   Dose∅, 15,   eff↓, 32,   eff↑, 88,   eff↝, 5,   eff∅, 1,   Half-Life↓, 7,   Half-Life↑, 4,   Half-Life↝, 6,   Half-Life∅, 1,   MDR1↓, 6,   MRP1/ABCC1↓, 1,   P450↓, 1,   RadioS↑, 45,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 71,   Synergy↑, 434,   TET2↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 4,   ALAT↑, 1,   ALP↓, 2,   AR↓, 10,   ascitic↓, 1,   AST↓, 2,   AST↑, 1,   BG↓, 3,   BRCA1↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 19,   ERα/ESR1↓, 1,   EstroRS/ERS↑, 1,   EZH2↓, 3,   Ferritin↓, 2,   FOXM1↓, 3,   GutMicro↑, 6,   HER2/EBBR2↓, 7,   hTERT/TERT↓, 10,   IL6↓, 21,   Ki-67↓, 17,   Ki-67↑, 1,   KRAS↓, 2,   LDH↓, 10,   p‑LDH↓, 1,   Myc↓, 4,   Myc↑, 1,   NOS2↓, 1,   PD-L1↓, 6,   PD-L1↑, 1,   PSA↓, 5,   PSA∅, 1,   TG/TAG↓, 1,   TP53↓, 2,   TP53↑, 3,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 2,   AntiCan↑, 32,   AntiCan∅, 1,   antiNeop↑, 3,   AntiTum↓, 2,   AntiTum↑, 17,   cachexia↓, 1,   cardioP↑, 5,   CardioT↓, 1,   chemoP↑, 19,   chemoPv↑, 7,   ChemoSideEff↓, 11,   fatigue↓, 2,   hepatoP↓, 1,   hepatoP↑, 5,   memory↑, 1,   NDRG1↑, 1,   neuroP↑, 5,   NP/CIPN↓, 3,   OS↑, 30,   PDE4↓, 1,   Pin1↓, 2,   QoL↑, 7,   QoL∅, 1,   radioP↑, 7,   Remission↑, 3,   RenoP↑, 3,   Risk↓, 20,   Risk↑, 2,   Risk∅, 1,   toxicity↓, 20,   toxicity↑, 3,   toxicity↝, 9,   toxicity∅, 5,   TumVol↓, 17,   TumW↓, 8,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   CD8+↑, 7,   Sepsis↓, 2,  
Total Targets: 887

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 6,   compII↑, 1,   diuretic↑, 2,   NA↑, 1,   NeuroI↓, 1,   PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   Stress↓, 1,   Stroke↓, 3,   TRPA1↑, 1,   UFR↑, 1,   UR↓, 1,   β-HEX↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 5,   antiOx↑, 65,   Catalase↑, 26,   Copper↓, 1,   Fenton↓, 1,   Ferroptosis↓, 3,   GPx↑, 20,   GPx4↑, 1,   GSH↑, 24,   GSR↑, 3,   GSSG↓, 1,   GSSG∅, 1,   GSTA1↑, 1,   GSTs↑, 9,   H2O2↓, 1,   H2O2↑, 1,   H2O2∅, 1,   HDL↑, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 20,   Iron↓, 1,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↝, 1,   lipid-P↓, 23,   MDA↓, 19,   MDA↑, 1,   MPO↓, 4,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 38,   PARK2↑, 1,   Prx↑, 1,   RNS↓, 2,   ROS?, 1,   ROS↓, 73,   ROS↝, 1,   mt-ROS?, 1,   SAM-e↑, 1,   selenoP↑, 1,   SOD↑, 35,   SOD2↑, 2,   TAC↑, 5,   TBARS↓, 1,   Trx↑, 1,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 2,   ATP↓, 1,   ATP↑, 7,   ATP↝, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   FIS1↓, 2,   Insulin↑, 1,   MMP↑, 5,   mtDam↓, 2,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   adiP↑, 1,   ALAT↓, 10,   AMPK↓, 1,   AMPK↑, 8,   p‑cMyc↑, 1,   CREB↑, 1,   CYP3A2↓, 1,   cytoP450↓, 1,   FASN↓, 1,   glucose↓, 5,   glucose↝, 1,   GlucoseCon↑, 2,   GLUT2↑, 1,   H2S↑, 1,   LDH↓, 3,   LDL↓, 6,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 1,   PONs↑, 1,   PPARγ↓, 2,   PPARγ↑, 2,   p‑PPARγ↓, 1,   SIRT1↑, 6,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 2,   BAX↑, 1,   Bax:Bcl2↓, 2,   Bcl-2↓, 2,   Bcl-2↑, 1,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 7,   Casp3↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 2,   Casp9↑, 1,   Cyt‑c↓, 3,   Fas↓, 1,   FasL↓, 1,   Ferroptosis↓, 3,   GADD34↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 10,   JNK↓, 2,   p‑JNK↓, 1,   MAPK↓, 7,   MAPK↑, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 2,   AKT1↓, 1,   TRPV3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   AntiThr↑, 2,   other↓, 3,   other↑, 14,   other↝, 8,   other∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   p‑eIF2α↓, 1,   ER Stress↓, 4,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3II↑, 1,   MitoP↑, 2,   p62↓, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   GADD45A↑, 1,   P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Choline↑, 1,   Diff↝, 1,   ERK↓, 3,   ERK↑, 2,   GH↑, 1,   GSK‐3β↓, 6,   p‑GSK‐3β↑, 1,   HDAC↓, 1,   IGF-1↑, 1,   IGFBP1↑, 1,   mTOR↓, 3,   mTOR↑, 1,   neuroG↑, 1,   PI3K↓, 5,   PI3K↑, 2,   PTEN↓, 1,   PTEN↑, 1,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 1,   TumCG∅, 1,   VGSC↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 3,   AntiAg↑, 8,   AP-1↓, 3,   APP↓, 1,   Ca+2?, 1,   Ca+2↓, 1,   Ca+2↑, 1,   Ca+2↝, 3,   Cartilage↑, 2,   Ki-67↓, 1,   LRP1↑, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 3,   MUC1↑, 1,   PKCδ?, 1,   PKCδ↓, 2,   PKCδ↑, 2,   RAGE↓, 2,   serineP↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   VCAM-1↓, 4,   ZO-1↑, 1,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 2,   ATF4↓, 2,   EGFR↓, 1,   eNOS↓, 1,   EPR↑, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO?, 1,   NO↓, 9,   NO↑, 1,   TXA2↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 12,   BBB↝, 1,   GastroP↑, 2,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 2,   OCLN↑, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 17,   COX2/PTGS2↑, 1,   CRP↓, 6,   ICAM-1↓, 3,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1?, 1,   IL1↓, 3,   IL10↓, 3,   IL10↑, 3,   IL12↓, 1,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 20,   IL2↓, 2,   IL33↓, 1,   IL4↓, 2,   IL6?, 1,   IL6↓, 32,   IL8↓, 3,   Imm↓, 1,   Imm↑, 7,   Inflam↓, 86,   Inflam↑, 2,   LPS↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 1,   MCP1/CCL2↝, 1,   MUC2↓, 1,   MyD88↓, 1,   NF-kB↓, 28,   PGE2↓, 8,   PSA↓, 2,   TLR2↓, 2,   TLR4↓, 2,   TLR4↑, 1,   TNF-α↓, 38,   TNF-α↑, 1,   VitD↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 3,   AChE↓, 8,   BChE↓, 2,   BDNF↓, 1,   BDNF↑, 5,   GABA↑, 2,   MAOA↓, 2,   NGF↑, 1,   tau↓, 6,   p‑tau↓, 6,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   Aβ↓, 16,   BACE/β-secretase↓, 7,   NLRP3↓, 8,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   DHT↓, 1,   Leptin↓, 1,   testos↓, 1,   testos↑, 1,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 23,   BioAv↑, 45,   BioAv⇅, 2,   BioAv↝, 15,   BioEnh↑, 3,   ChemoSen↑, 1,   Dose↑, 4,   Dose↝, 25,   eff↓, 1,   eff↑, 15,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 9,   MRP1/ABCC1↓, 1,   P450↓, 2,   selectivity↑, 2,   Synergy↑, 73,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 10,   ALP↓, 2,   AST↓, 13,   BloodF↑, 2,   BMD↑, 3,   BMPs↑, 1,   BP↓, 7,   BP↝, 1,   Calcium↑, 1,   creat↓, 2,   CRP↓, 6,   EGFR↓, 1,   GutMicro↑, 14,   Hcy/homoC↝, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 32,   Ki-67↓, 1,   LDH↓, 3,   Mag↑, 1,   MUC19↓, 1,   PSA↓, 2,   RAGE↓, 2,   Urea↓, 1,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 4,   antiAll↑, 9,   AntiArt↑, 4,   AntiCan↑, 10,   AntiDiabetic↑, 13,   AntiP↑, 1,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 3,   cardioP↓, 1,   cardioP↑, 31,   CardioT↓, 1,   chemoP↑, 10,   chemoPv↑, 5,   ChemoSideEff↓, 1,   cognitive↑, 24,   cognitive↝, 1,   hepatoP↑, 24,   memory↑, 20,   Mood↑, 1,   motorD↑, 3,   neuroP↓, 1,   neuroP↑, 55,   Obesity↓, 8,   Pain↓, 4,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 10,   Risk↓, 4,   Sleep↑, 2,   Strength↑, 1,   toxicity↓, 28,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 6,   toxicity∅, 6,   Weight↓, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↓, 1,   AntiFungal↑, 3,   AntiViral↑, 5,   Bacteria↓, 15,   Diar↓, 2,   IRF3↓, 1,   Sepsis↓, 1,  
Total Targets: 383

Scientific Paper Hit Count for: Synergy, Synergy
23 Curcumin
15 Vitamin C (Ascorbic Acid)
14 Quercetin
13 Chrysin
12 Sulforaphane (mainly Broccoli)
12 Dichloroacetate
11 Metformin
11 Lycopene
10 EGCG (Epigallocatechin Gallate)
9 Chemotherapy
9 Resveratrol
8 Silver-NanoParticles
8 Artemisinin
8 Ashwagandha(Withaferin A)
8 Fisetin
7 Atorvastatin
7 Berberine
7 immunotherapy
6 Radiotherapy/Radiation
6 Hyperthermia
6 Magnetic Fields
6 Apigenin (mainly Parsley)
6 Vitamin K2
6 Silymarin (Milk Thistle) silibinin
6 Inositol
6 Bicarbonate(Sodium)
6 Thymoquinone
5 Melatonin
5 Dipyridamole
5 Carvacrol
5 diet FMD Fasting Mimicking Diet
5 Fenbendazole
5 Formononetin
5 Gambogic Acid
5 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
5 Rosmarinic acid
4 3-bromopyruvate
4 Auranofin
4 Alpha-Lipoic-Acid
4 Gemcitabine (Gemzar)
4 Propolis -bee glue
4 Capsaicin
4 salinomycin
4 diet Methionine-Restricted Diet
4 Dandelion Root
4 Disulfiram
4 Hydrogen Gas
4 Matrine
4 Phenethyl isothiocyanate
4 Piperlongumine
4 Urolithin
4 VitK3,menadione
3 1,8-Cineole
3 Photodynamic Therapy
3 Astaxanthin
3 beta-carotene(VitA)
3 borneol
3 Caffeic acid
3 Carnosic acid
3 chaetocin
3 chitosan
3 5-fluorouracil
3 Copper and Cu NanoParticles
3 Piperine
3 Emodin
3 Eugenol
3 Genistein (soy isoflavone)
3 Honokiol
3 Ivermectin
3 Juglone
3 Kaempferol
3 Luteolin
3 Terpinen-4-ol / Tea Tree Oil
3 Selenium NanoParticles
2 2-DeoxyGlucose
2 cetuximab
2 Vitamin B12
2 Folic Acid, Vit B9
2 chemodynamic therapy
2 Trichostatin A
2 Allicin (mainly Garlic)
2 Andrographis
2 isoquercitrin
2 Aspirin
2 Baicalein
2 Biochanin A
2 Betulinic acid
2 Lutein
2 Zeaxanthin
2 hydroxychloroquine
2 Thymol-Thymus vulgaris
2 Sorafenib (brand name Nexavar)
2 Chlorogenic acid
2 Citric Acid
2 Coenzyme Q10
2 Ellagic acid
2 Bortezomib
2 Docosahexaenoic Acid
2 Oxygen, Hyperbaric
2 Vitamin A, Retinoic Acid
2 erastin
2 Exercise
2 Ferulic acid
2 ferumoxytol
2 Fucoidan
2 Gallic acid
2 Cisplatin
2 Gamma-aminobutyric acid
2 doxorubicin
2 Ginkgetin
2 Gossypol/AT-101
2 HydroxyCitric Acid
2 Spermidine
2 Lecithin
2 Niclosamide (Niclocide)
2 Phenylbutyrate
2 Shikonin
2 Selenite (Sodium)
2 Vitamin D3
1 Serotonin, 5-hydroxytryptamine
1 dietMediterranean
1 EMF
1 SonoDynamic Therapy UltraSound
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anti-oxidants
1 Acer okamotoanum
1 5-Aminolevulinic acid
1 almonertinib
1 D-limonene
1 Huperzine A/Huperzia serrata
1 Bufalin/Huachansu
1 Bifidobacterium
1 Boron
1 Boswellia (frankincense)
1 Butyrate
1 Cannabidiol
1 Centella asiatica / Gotu kola → asiaticoside
1 Beta‐Lapachone
1 Chlorophyllin
1 Rutin
1 Trastuzumab
1 Cinnamon
1 Hydroxycinnamic-acid
1 Selenium
1 Cucurbitacin
1 Dasatinib/Phyrago
1 Diclofenac
1 diet Ketogenic
1 Docetaxel
1 Ascorbyl Palmitate
1 Mistletoe/Viscum album Extracts
1 Echinacea
1 Electrical Pulses
1 Beta-Caryophyllene
1 temozolomide
1 Geldanamycin
1 Radicicol/monorden
1 Arsenic trioxide
1 olaparib/LYNPARZA
1 Galloflavin
1 verapamil
1 Garcinol
1 Ginkgo biloba
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Ginkgolide B
1 Gold NanoParticles
1 Calorie Restriction Mimetics
1 iodine
1 Inulin Prebiotic
1 isoorientin
1 itraconazole
1 Recombinant Methioninase
1 tumor necrosis factor-related apoptosis-inducing ligand
1 lambertianic acid
1 Lapatinib
1 low dose naltrexone
1 Licorice
1 Linalool
1 Vitamin E
1 Magnolol
1 methotrexate
1 Magnetic Field Rotating
1 Magnesium
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Naringin
1 Marjoram (Origanum majorana)
1 Paclitaxel/Taxol
1 Phosphatidylserine
1 Psoralidin
1 Parthenolide
1 Pterostilbene
1 Sulfasalazine
1 acetaminophen
1 acetazolamide
1 statins
1 triptolide
1 Turmerones
1 Vitexin
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1849  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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