NF-kB Cancer Research Results

NF-kB, Nuclear factor kappa B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
NF-kB signaling
Nuclear factor kappa B (NF-κB) is a transcription factor that plays a crucial role in regulating immune response, inflammation, cell proliferation, and survival.
NF-κB is often found to be constitutively active in many types of cancer cells. This persistent activation can promote tumorigenesis by enhancing cell survival, proliferation, and metastasis.
Scientific Papers found: Click to Expand⟱
164- CUR,    Anti-tumor activity of curcumin against androgen-independent prostate cancer cells via inhibition of NF-κB and AP-1 pathway in vitro
- in-vitro, Pca, PC3
NF-kB↓, AP-1↓, TumCG↓, TumCCA↑,
160- CUR,    Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2
- in-vitro, Pca, NA
CXCc↓, IκB↓, NF-kB↓, COX2/PTGS2↓, SPARC↓, EFEMP↓, IKKα↓,
170- CUR,    Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis
- vitro+vivo, Pca, PC3
TRAILR↑, BAX↑, P21↑, p27/CDKN1B↑, NF-kB↓, cycD1/CCND1↓, VEGF↓, uPA↓, MMP2↓, MMP9↓, Bcl-2↓, Bcl-xL↓,
182- CUR,  RES,  GI,    Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
p38↓, MKP5↑, TNF-α↓, COX2/PTGS2↓, NF-kB↓,
183- CUR,    Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
AR↓, AP-1↓, NF-kB↓, CBP↓,
6227- CUR,    Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic Combinations
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, mTOR↓, JAK↓, STAT3↓, MAPK↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, GSK‐3β↓, cMyc↓, survivin↓, Axin2↑, TumCCA↑, PTEN↑, P53↑, ROS↑, Casp3↑, PARP↑, Ferroptosis↑, angioG↓, TumCI↓, TumMeta↓, BioAv↓, Half-Life↓, ChemoSen↑,
6211- CUR,    The effect of curcumin on hypoxia in the tumour microenvironment as a regulatory factor in cancer
- Review, Var, NA
HIF-1↓, VEGF↓, angioG↓, RadioS↑, ChemoSen↑, other↝, Apoptosis↑, TumCG↓, TumMeta↓, BioAv↓, COX2/PTGS2↓, CD31/PECAM-1↓, IL8↓, TGF-β↓, NF-kB↓, JAK2↓, STAT3↓,
6213- CUR,    Potentiality of Curcumin Against Radio-Chemotherapy Induced Oral Mucositis: A Review
- Review, Var, NA
*antiOx↑, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *NF-kB↓, *NRF2↑, *Wound Healing↑, *eff↑,
6214- CUR,    Curcumin Nanoparticles-related Non-invasive Tumor Therapy, and Cardiotoxicity Relieve
TumCD↓, TumCI↓, *Inflam↓, *antiOx↓, *AntiTum↓, NF-kB↓, COX2/PTGS2↓, Casp9↓, ROS↑, BioAv↑, RadioS↑, ChemoSen↑, Imm↑, PhotoS↑, sonoS↑, 5LO↓, iNOS↓, IL2↓, TNF-α↓, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, Apoptosis↑, ER Stress↑, cycD1/CCND1↓, CDK2↓, CycB/CCNB1↓, TumCCA↑, MMPs↓, *radioP↑, chemoP↑, hepatoP↑, cardioP↑, eff↑, PhotoS↑, eff↑, ROS↑, GSH↓,
6215- CUR,    Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *BioAv↓, NF-kB↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, DNMTs↓, TumCI↓, TumMeta↓, *BioAv↑, *BioAv↑, angioG↓, VEGF↓, MMPs↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *HO-1↑, *NRF2↑, mTOR↓, GSK‐3β↓, FOXO1↓, *radioP↑, *IL1↓, *IL6↓, *TNF-α↓, HATs↓, HDAC↓, ROS↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, COX1↓, COX2/PTGS2↓, PGE2↓, *cytoP450↓, ChemoSen↑, cardioP↑, eff↑,
6216- CUR,    Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials
- Review, Var, NA
TumCG↓, angioG↓, EMT↓, TumCI↓, TumMeta↓, *GutMicro↑, *BioAv↓, *HO-1↑, *ROS↓, *COX2/PTGS2↓, *iNOS↓, PKCδ↓, EGFR↓, NF-kB↓, cJun↓, cFos↓, cMyc↓, Akt↓, PI3K↓, CDK4↓, *TNF-α↓, *CRP↓, *IL6↓, MMP9↓, VEGF↓, JAK↓, STAT↓, IL1↓, IL2↓, IL6↓, IL8↓, IL12↓, MCP1/CCL2↓, Apoptosis↑, ER Stress↑, 5LO↓, XO↓, *NRF2↑, *HO-1↑, *AChE↓, *neuroP↑, *glucose↓, *GLUT2↑, *GLUT3↑, *GLUT4↑, *GlucoseCon↑, *AMPK↑, *BMD↑, *MDA↓, *eff↑, eff↑, P53↑, BAX↑, DNAdam↑, Bcl-2↓, CSCs↓, ALDH↓, CD133↑,
6229- CUR,    NF-kB_and_Wntb-catenin_pathways_in_cervical_cancer_cells">Curcumin inhibits NF-kB and Wnt/β-catenin pathways in cervical cancer cells
- in-vitro, Cerv, NA
TumCI↓, TumCP↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓,
6212- CUR,  Rad,    Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers
- Review, Var, NA
RadioS↑, *radioP↑, EGFR↓, TGF-β↓, ROS↑, P53↑, PI3K↓, NF-kB↓, COX2/PTGS2↓, EMT↓, Hif1a↓, HSP90↓, mTOR↓, *Catalase↑, *SOD↑, *MDA↑, *Wound Healing↑, *hepatoP↑, *NF-kB↓, *ROS↓,
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1↓, Beclin-1↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2/PTGS2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
6222- CUR,    Anticancer Molecular Mechanisms of Curcuminoids: An Updated Review of Clinical Trials
- Review, Var, NA
RadioS↑, ChemoSen↑, MMPs↓, TumMeta↓, TumCI↓, Inflam↓, NF-kB↓, BioAv↓, BioAv↑, MAPK↓, PI3K↓, Akt↓, *ROS↓, *MDA↓, *lipid-P↓, *Half-Life↓, mTOR↓,
6221- CUR,    Oxidative Stress and Cancer: Harnessing the Therapeutic Potential of Curcumin and Analogues Against Cancer
- Review, Var, NA
NF-kB↓, Imm↑, *TAC↑, *MDA↓, ROS↑, TumAuto↑, TumCCA↑, Keap1↑, ChemoSen↑, ER Stress↑, eff↓, TrxR↓, STAT3↓, *BioAv↓,
6219- CUR,    Natural Products and Altered Metabolism in Cancer: Therapeutic Targets and Mechanisms of Action
- Review, Var, NA
PI3K↓, Akt↓, NF-kB↓, BioAv↑, GSK‐3β↓, Slug↓, Cyt‑c↑, Casp3↑, Casp9↑,
6218- CUR,    Exploring the Thioredoxin System as a Therapeutic Target in Cancer: Mechanisms and Implications
- Review, Var, NA
NF-kB↓, TrxR↓, ROS↑, TumMeta↓, TumCD↑, RadioS↑, BioAv↝, BioAv↑,
6217- CUR,    Curcumin: a therapeutic strategy in cancers by inhibiting the canonical WNT/β-catenin pathway
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, PPARγ↑, Akt↓, *ROS↓, *Inflam↓, Bcl-2↓, GSK‐3β↑, NF-kB↓, COX2/PTGS2↓,
6235- CUSP9,    Exhaustive in vitro evaluation of the 9-drug cocktail CUSP9 for treatment of glioblastoma
- in-vitro, GBM, NA
tumCV↓, NF-kB↓, HH↓, 5HT↓,
6237- CUSP9,    CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide
- NA, GBM, NA
PI3K↓, Akt↓, ROS↑, NF-kB↓, TNF-α↓, TLR2↓, other↓, TrxR↓, STAT3↓, MMPs↓, COX1↓, COX2/PTGS2↓, CA↓, ALDH↓, P-gp/ABCB1↓, HH↓, 5LO↓, mTOR↓, CycD3↓, Proteasome↓, other↓, MMP2↓, MMP9↓, ALDH↓, Copper↓,
6246- Cyc,    Cyclopamine is a novel Hedgehog signaling inhibitor with significant anti-proliferative, anti-invasive and anti-estrogenic potency in human breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
HH↓, TumCP↓, TumCCA↓, TumCI↓, NF-kB↓, MMP2↓, MMP9↓, ERα/ESR1↓, cycD1/CCND1↓,
7452- CYN,    Cynaropicrin inhibits pancreatic cancer cell viability and disrupts cellular redox homeostasis
- in-vitro, PC, PANC1
tumCV↓, Thiols↓, NF-kB↓, ROS↑,
7451- CYN,    Inhibitory effects of cynaropicrin on human melanoma progression by targeting MAPK, NF‐κB, and Nrf‐2 signaling pathways in vitro
- in-vitro, Melanoma, A375
TumCP↓, Casp3↑, Apoptosis↑, TumCMig↓, TumCI↓, ERK↓, NF-kB↓, ROS↓, HO-1↑, NRF2↑, Bcl-2↓, NF-kB↓, other↝,
7447- CYN,    Antiproliferative Effects of Cynaropicrin on Anaplastic Thyroid Cancer Cells
- in-vitro, Thyroid, 8505C - in-vitro, Thyroid, CAL62 - in-vitro, Thyroid, SW1736
tumCV↓, TumCCA↑, NF-kB↓, p‑STAT3↓, lipid-P↑, ROS∅,
7444- CYN,    The Sesquiterpene Lactone Cynaropicrin Manifests Strong Cytotoxicity in Glioblastoma Cells U-87 MG by Induction of Oxidative Stress
- in-vitro, GBM, U87MG
TumCG↓, Dose↝, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, TumAuto↑, p‑ERK↓, NF-kB↓, ChemoSen↑, eff↓,
6676- Deg,    Deguelin’s Anticancer Bioactivity: Challenges and Opportunities in Medicinal Chemistry
- Review, Var, NA
TumCP↓, Apoptosis↑, NF-kB↓, Wnt↓, TumCCA↑, TumMeta↑, antiOx↑, Inflam↓, angioG↓, Half-Life↑, MMP2↓, MMP9↓, Casp9↑, Casp3↑, EMT↓, PTEN↑, ChemoSen↑, toxicity↑, *BBB↑,
6673- Deg,    Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion
NF-kB↓, IKKα↓, TNFR 1↓, TumCP↓, TumCI↓,
6672- Deg,    Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice
- vitro+vivo, CRC, COLO205 - in-vitro, CRC, HCT116
Akt↑, AntiTum↑, IL8↓, p‑IKKα↓, NF-kB↓, TumCD↑, Apoptosis↑, cFLIP↓, Bcl-2↓, Bcl-xL↓, TumVol↓,
19- Deg,    Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
HH↓, Gli1↓, PTCH1↓, Sufu↓, MMP2↓, MMP9↓, PI3K/Akt↓, HIF-1↓, VEGF↓, IKKα↓, NF-kB↓, EMT↓, AMPK↑, mTOR↓, survivin↓, TumCG↓, Apoptosis↑, TumCMig↓, TumCI↓,
1442- Deg,    Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
- Review, Var, NA
PI3K/Akt↓, IKKα↓, AMP↓, mTOR↓, survivin↓, NF-kB↓, Apoptosis↑, TumCCA↑, toxicity↓, HSP90↓, Casp↑, TumCG↓, p27/CDKN1B↑, cycE/CCNE↓, angioG↓, Hif1a↓, VEGF↓, *toxicity↑,
1443- Deg,    Deguelin Action Involves c-Met and EGFR Signaling Pathways in Triple Negative Breast Cancer Cells
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-435 - in-vitro, BC, BT549
EGFR↓, Akt↓, p‑ERK↓, NF-kB↓, p‑STAT3↓, survivin↓, Myc↓, TumCG↓, cMET↓,
6705- DFC,    Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases
- Review, Var, NA
*Inflam↓, *Pain↓, *COX1↓, *COX2/PTGS2↓, *toxicity↝, *BioAv↑, *AntiAg↑, *neuroP↑, ROS↑, p73↑, Myc↓, lactateProd↓, TumCCA↑, PI3K↓, Akt↓, NF-kB↓, SOD2↓, *neuroP↑,
6748- DHA,    Docosahexaenoic acid enrichment of tumor phospholipid membranes increases tumor necroptosis in mice bearing triple negative breast cancer patient-derived xenografts
- in-vivo, BC, NA
TumCG↓, ChemoSen↑, NF-kB↓,
1085- DHA,  EPA,    DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappaB Activity in LPS-treated Human Umbilical Vein Endothelial Cells
- in-vitro, Nor, HUVECs
*COX2/PTGS2↓, *NF-kB↓, *PGE2↓, *IL6↓, *NF-kB↑,
6729- Dipy,    Dipyridamole prevents triple-negative breast-cancer progression
- Trial, BC, MDA-MB-231
TumCG↓, TumMeta↑, β-catenin/ZEB1↓, *AntiAg↑, TumCCA↑, Wnt↓, NF-kB↓,
6287- DL,    D-Limonene Is a Potential Monoterpene to Inhibit PI3K/Akt/IKK-α/NF-κB p65 Signaling Pathway in Coronavirus Disease 2019 Pulmonary Fibrosis
- in-vivo, Covid, NA
*PI3K↓, *Akt↓, *NF-kB↓,
6282- DL,    Limonene Exerts Anti-Inflammatory Effect on LPS-Induced Jejunal Injury in Mice by Inhibiting NF-κB/AP-1 Pathway
- in-vivo, IBD, NA
*RenoP↑, *creat↓, *Inflam↓, *TNF-α↓, *IL1β↓, *COX2/PTGS2↓, *ROS↓, *NRF2↑, *GastroP↑, *TLR4↓, *NF-kB↓, *AP-1↓, *Sepsis↓,
6349- DRE,    Dandelion root extract protects NCM460 colonic cells and relieves experimental mouse colitis
- vitro+vivo, Nor, NCM460
*Apoptosis↓, *ROS↓, *NF-kB↓, *other↓,
6318- DRE,    Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways
- vitro+vivo, CRC, HCT116 - NA, Nor, NCM460
TumCD↑, Apoptosis↑, Casp8↑, selectivity↑, TumCMig↓, selectivity↑, Dose↝, toxicity↓, TumCG↓, MMP↓, mt-ROS↑, *ROS↓, BID↑, Bcl-2↓, PARP↓, NF-kB↑, *NF-kB↓, Casp1↑, *Casp1↓, COX2/PTGS2↑, OXPHOS↓, ETC↓,
6353- DRE,  Cisplatin,    Insights Into Protective Mechanisms of Dandelion Leaf Extract Against Cisplatin-Induced Nephrotoxicity in Rats: Role of Inhibitory Effect on Inflammatory and Apoptotic Pathways
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *NF-kB↓, *Cyt‑c↓, *DNAdam↓, *GSH↑, *SOD↑, *Albumin↝, *creat↓, *BUN↓, *RenoP↑, *lipid-P↓, *TNF-α↓, *Casp3↓, *Casp9↓, *chemoP↑,
6358- DRE,    Dandelion root extracts and taraxasterol inhibit LPS‑induced colorectal cancer cell viability by blocking TLR4‑NFκB‑driven ACE2 and TMPRSS2 pathways
- in-vitro, CRC, NA
TLR4↓, NF-kB↓, TNF-α↓, IL4↓, IL6↓, tumCV↓,
6359- DRE,    Natural Health Products (NHP’s) and Natural Compounds as Therapeutic Agents for the Treatment of Cancer; Mechanisms of Anti-Cancer Activity of Natural Compounds and Overall Trends
- Review, Var, NA
*antiOx↑, *Inflam↓, Dose↝, PI3K↓, Akt↓, NF-kB↓,
6363- DRE,    Therapeutic Potential of Dandelion (Taraxacum officinale) Root Extract in Colon Cancer: A Comprehensive Review
- in-vitro, CRC, NA
Apoptosis↑, *Inflam↓, TLR4↓, NF-kB↓, *GutMicro↑, mtDam↑, *ROS↓, Casp1↑, TNF-α↑, Bcl-2↓, PARP↓, MMP↓, Cyt‑c↓, Casp3↑, TumVol↓, COX2/PTGS2↓, iNOS↓, ROS↑, selectivity↑, TumCMig↓, TumCI↓, ER Stress↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, TumCCA↑, cycD1/CCND1↓, P21↓, P53↑, BioAv↝, Half-Life↝,
6744- DSF,    Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, T47D
TumCD↑, ChemoSen↑, BAX↑, Apoptosis↑, CSCs↓, ROS↑, eff↝, JNK↑, p38↑, NF-kB↓,
4914- DSF,  immuno,    Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
- Review, Var, NA
AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp/ABCB1↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, eff↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,
4916- DSF,  Cu,    The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Imm↑, ROS↑, NF-kB↓, chemoP↑, JNK↑, FOXO↑, Myc↑, TumCCA↑, Apoptosis↑, RadioS↑, PD-L1↑, eff↑, CSCs↓, Dose↝, Half-Life↑,
4915- DSF,  Cu,    Disulfiram: A novel repurposed drug for cancer therapy
- Review, Var, NA
ROS↑, TumCD↑, NF-kB↓, CSCs↓, ChemoSen↑, RadioS↑, eff↑, selectivity↑, Proteasome?,
5008- DSF,  Cu,    Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
- in-vitro, HCC, NA
selectivity↑, TumCD↑, TumCMig↓, TumCI↓, angioG↓, mtDam↑, Iron↑, lipid-P↑, Ferroptosis↑, NF-kB↑, p‑p62↑, Keap1↓, eff↑, eff↓, ChemoSen↑,
5012- DSF,  Cu,    Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems
ROS↑, ALDH↓, TumCP↓, CSCs↓, angioG↓, TumMeta↓, DNAdam↑, Proteasome↓, SOD1↓, GSR↓, ox-GSSG↑, GSH/GSSG↓, MMP↓, Akt↓, cycD1/CCND1↓, NF-kB↓, CSCs↓, MAPK↓, angioG↓, DrugR↓, EMT↓, Vim↓, BioAv↑, eff↑,

Showing Research Papers: 351 to 400 of 966
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 966

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Copper↓, 1,   Ferroptosis↑, 3,   GPx4↓, 1,   GSH↓, 2,   GSH/GSSG↓, 1,   GSR↓, 1,   ox-GSSG↑, 1,   HO-1↑, 2,   Iron↑, 2,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↑, 3,   MDA↑, 1,   NADH↓, 1,   NRF2↑, 3,   OXPHOS↓, 2,   ROS↓, 1,   ROS↑, 19,   ROS∅, 1,   mt-ROS↑, 1,   SOD↓, 1,   SOD1↓, 1,   SOD2↓, 1,   Thiols↓, 1,   TrxR↓, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   ETC↓, 2,   MKP5↑, 1,   MMP↓, 6,   mtDam↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMP↓, 1,   AMPK↑, 3,   cMyc↓, 2,   FASN↓, 1,   G6PD↓, 1,   GLS↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   lactateProd↑, 1,   LDHA↓, 1,   PDK1↓, 1,   PI3K/Akt↓, 2,   PKM2↓, 1,   PPARγ↑, 1,   SCD1↓, 1,   SREBP2↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 12,   Akt↑, 1,   Apoptosis↑, 16,   BAX↑, 4,   Bcl-2↓, 8,   Bcl-xL↓, 2,   BID↑, 1,   Casp↑, 3,   Casp1↑, 2,   Casp3↑, 6,   Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 3,   CBP↓, 1,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 3,   Ferroptosis↑, 3,   iNOS↓, 2,   JNK↑, 2,   MAPK↓, 4,   MCT1↓, 1,   Myc↓, 2,   Myc↑, 1,   p27/CDKN1B↑, 2,   p38↓, 1,   p38↑, 1,   Proteasome?, 1,   Proteasome↓, 2,   survivin↓, 4,   TNFR 1↓, 1,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 6,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   HATs↓, 1,   other↓, 2,   other↝, 2,   PhotoS↑, 2,   sonoS↑, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↑, 1,   ER Stress↑, 4,   HSP90↓, 2,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   p‑p62↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   DNMTs↓, 2,   P53↑, 5,   p73↑, 1,   PARP↓, 2,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 5,   CycD3↓, 1,   cycE/CCNE↓, 1,   P21↓, 1,   P21↑, 1,   TumCCA↓, 1,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 5,   Axin2↑, 1,   CD133↑, 1,   cFos↓, 1,   cMET↓, 1,   CSCs↓, 7,   EMT↓, 6,   ERK↓, 1,   p‑ERK↓, 2,   FOXO↑, 1,   FOXO1↓, 1,   Gli1↓, 1,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   HDAC↓, 2,   HH↓, 4,   mTOR↓, 8,   NOTCH↓, 1,   PI3K↓, 9,   PTCH1↓, 1,   PTEN↑, 2,   STAT↓, 1,   STAT3↓, 5,   p‑STAT3↓, 2,   Sufu↓, 1,   TumCG↓, 11,   Wnt↓, 7,  

Migration(tgid=13) ⓘ

5LO↓, 3,   AP-1↓, 3,   CA↓, 1,   CD31/PECAM-1↓, 1,   EFEMP↓, 1,   MMP2↓, 5,   MMP9↓, 6,   MMPs↓, 5,   PKCδ↓, 1,   Slug↓, 1,   SPARC↓, 1,   TGF-β↓, 2,   TumCI↓, 14,   TumCMig↓, 6,   TumCP↓, 8,   TumMeta↓, 9,   TumMeta↑, 2,   uPA↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 10,   ATF4↑, 1,   EGFR↓, 3,   HIF-1↓, 2,   Hif1a↓, 3,   VEGF↓, 7,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2/PTGS2↓, 10,   COX2/PTGS2↑, 1,   CXCc↓, 1,   IKKα↓, 4,   p‑IKKα↓, 1,   IL1↓, 1,   IL12↓, 1,   IL2↓, 2,   IL4↓, 1,   IL6↓, 2,   IL8↓, 3,   Imm↑, 5,   Inflam↓, 2,   IκB↓, 1,   JAK↓, 2,   JAK2↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 43,   NF-kB↑, 2,   NK cell↑, 1,   PD-L1↑, 1,   PGE2↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 4,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   ERα/ESR1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 6,   BioAv↝, 3,   ChemoSen↑, 14,   Dose↝, 5,   DrugR↓, 1,   eff↓, 3,   eff↑, 11,   eff↝, 1,   Half-Life↓, 1,   Half-Life↑, 2,   Half-Life↝, 1,   RadioS↑, 8,   selectivity↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 3,   ERα/ESR1↓, 1,   GutMicro↑, 1,   IL6↓, 2,   Myc↓, 2,   Myc↑, 1,   PD-L1↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 2,   cardioP↑, 2,   chemoP↑, 2,   hepatoP↑, 1,   toxicity↓, 2,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 232

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 4,   Catalase↑, 3,   GSH↑, 2,   GSTs↑, 1,   HO-1↑, 3,   lipid-P↓, 3,   MDA↓, 3,   MDA↑, 1,   NRF2↑, 4,   ROS↓, 10,   SOD↑, 4,   TAC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   BUN↓, 1,   cytoP450↓, 1,   glucose↓, 1,   GlucoseCon↑, 1,   GLUT2↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 2,   Casp1↓, 1,   Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 4,   CRP↓, 1,   IL1↓, 1,   IL1β↓, 1,   IL6↓, 3,   Inflam↓, 10,   NF-kB↓, 8,   NF-kB↑, 1,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 3,   eff↑, 2,   Half-Life↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Albumin↝, 1,   BMD↑, 1,   creat↓, 2,   CRP↓, 1,   GutMicro↑, 2,   IL6↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↓, 1,   chemoP↑, 1,   hepatoP↑, 1,   neuroP↑, 3,   Pain↓, 1,   radioP↑, 3,   RenoP↑, 2,   toxicity↑, 1,   toxicity↝, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 69

Scientific Paper Hit Count for: NF-kB, Nuclear factor kappa B
71 Curcumin
43 Thymoquinone
28 Resveratrol
27 Fisetin
24 Propolis -bee glue
22 Quercetin
22 Lycopene
21 EGCG (Epigallocatechin Gallate)
20 Betulinic acid
19 Baicalein
19 Sulforaphane (mainly Broccoli)
19 Silymarin (Milk Thistle) silibinin
16 Apigenin (mainly Parsley)
16 Ashwagandha(Withaferin A)
16 Garcinol
15 Alpha-Lipoic-Acid
14 Eugenol
14 Shikonin
13 Boswellia (frankincense)
13 Hydrogen Gas
13 isoorientin
12 Silver-NanoParticles
12 Artemisinin
12 Chrysin
12 Emodin
12 Honokiol
11 Cisplatin
11 Berberine
11 Caffeic Acid Phenethyl Ester (CAPE)
11 Rosmarinic acid
10 Beta-Caryophyllene
10 Luteolin
9 Magnetic Fields
9 Radiotherapy/Radiation
8 Capsaicin
8 Chlorogenic acid
8 Crocetin
8 Disulfiram
8 Isoliquiritigenin
8 Phenethyl isothiocyanate
7 Selenite (Sodium)
7 Allicin (mainly Garlic)
7 Caffeic acid
7 Hyperoside
7 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
7 Nimbolide
7 Parthenolide
7 Pterostilbene
7 Vitamin K2
6 Isovitexin
6 Ginger/6-Shogaol/Gingerol
6 Deguelin
6 Dandelion Root
6 Copper and Cu NanoParticles
6 Gambogic Acid
6 Magnolol
5 Anethole/trans-Anethole
5 Boron
5 Celastrol
5 Cinnamon
5 Hydroxycinnamic-acid
5 Ellagic acid
5 Piperine
5 Ferulic acid
5 Graviola
5 HydroxyTyrosol
5 Indole-3-carbinol
5 Piperlongumine
5 Urolithin
5 Vitamin C (Ascorbic Acid)
4 Gemcitabine (Gemzar)
4 Astaxanthin
4 Docetaxel
4 Berbamine
4 borneol
4 Chemotherapy
4 Ursolic acid
4 Cynaropicrin
4 Formononetin
4 Paclitaxel/Taxol
4 Hibiscus sabdariffa
4 Inositol
3 1,8-Cineole
3 Auranofin
3 Astragalus
3 Citric Acid
3 beta-glucans
3 xanthohumol
3 Bromelain
3 α-Bisabolol / Chamomile oil
3 Butyrate
3 Carnosic acid
3 Carvacrol
3 Cat’s Claw
3 Celecoxib
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Cucurbitacin
3 Docosahexaenoic Acid
3 eicosapentaenoic acid
3 Gallic acid
3 Genistein (soy isoflavone)
3 Geraniol
3 Orlistat
3 Oleuropein
3 Rutin
3 Sulfasalazine
2 Ajoene (compound of Garlic)
2 5-fluorouracil
2 immunotherapy
2 Baicalin
2 Biochanin A
2 Brucea javanica
2 brusatol
2 Zinc
2 Centella asiatica / Gotu kola → asiaticoside
2 Chlorophyllin
2 Echinacea
2 Photodynamic Therapy
2 CUSP9
2 D-limonene
2 Ginkgo biloba-EGb 761
2 Eurycomanone
2 Evodiamine
2 Ginkgo biloba
2 Ginkgolide B
2 Ginkgetin
2 Ginseng
2 Grapeseed extract
2 Proanthocyanidins
2 Inulin Prebiotic
2 Melatonin
2 Methyl salicylate / Sweet Birch oil
2 Methylsulfonylmethane
2 Naringin
2 Niclosamide (Niclocide)
2 Phenylbutyrate
2 Plumbagin
2 Psoralidin
2 salinomycin
2 Selenium NanoParticles
2 Aflavin-3,3′-digallate
2 Vitexin
1 2-DeoxyGlucose
1 Anthocyanins
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Arctigenin
1 Aloe anthraquinones
1 Cannabidiol
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Selenium
1 Bruteridin(bergamot juice)
1 Carnosine
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chitosan
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Galantamine
1 Lecithin
1 Oxygen, Hyperbaric
1 methylseleninic acid
1 Cyclopamine
1 Diclofenac
1 Dipyridamole
1 methotrexate
1 Ascorbyl Palmitate
1 flavonoids
1 Bortezomib
1 Fucoidan
1 Ginkgolic acids
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Siegesbeckia glabrescens
1 HydroxyCitric Acid
1 Hops (Humulus lupulus)
1 Isobavachalcone
1 isoflavones
1 isoquercitrin
1 Juglone
1 Magnetic Field Rotating
1 Moringa oleifera
1 Mushroom Chaga
1 Neem
1 Oroxylin A
1 Propyl gallate
1 temozolomide
1 Phenolic Acids
1 Polyphenols
1 Kaempferol
1 Perilla
1 Salvia officinalis
1 Sanguinarine
1 Sesame seeds and Oil
1 Taurine
1 Terminalia bellirica
1 Tomatine
1 Turmerones
1 Thymol-Thymus vulgaris
1 Vitamin B1/Thiamine
1 Vitamin D3
1 probiotics
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:214  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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