NRF2 Cancer Research Results

NRF2, nuclear factor erythroid 2-related factor 2: Click to Expand ⟱
Source: TCGA
Type: Antiapoptotic
Nrf2 is responsible for regulating an extensive panel of antioxidant enzymes involved in the detoxification and elimination of oxidative stress. Thought of as "Master Regulator" of antioxidant response.
-One way to estimate Nrf2 induction is through the expression of NQO1.
NQO1, the most potent inducer:
SFN 0.2 μM,
quercetin (2.5 μM),
curcumin (2.7 μM),
Silymarin (3.6 μM),
tamoxifen (5.9 μM),
genistein (6.2 μM ),
beta-carotene (7.2μM),
lutein (17 μM),
resveratrol (21 μM),
indol-3-carbinol (50 μM),
chlorophyll (250 μM),
alpha-cryptoxanthin (1.8 mM),
and zeaxanthin (2.2 mM)

1. Raising Nrf2 enhances the cell's antioxidant defenses and ↓ROS. This strategy is used to decrease chemo-radio side effects.
2. Downregulating Nrf2 lowers antioxidant defenses and ↑ROS. In cancer cells this leads to DNA damage, and cell death.
3. However there are some cases where increasing Nrf2 paradoxically causes an increase in ROS (cancer cells). Such as cases of Mitochondial overload, signal crosstalk, reductive stress

-In some cases, Nrf2 is overexpressed in cancer cells, which can lead to the activation of genes involved in cell proliferation, angiogenesis, and metastasis. This can contribute to the development of resistance to chemotherapy and targeted therapies.
-Increased Nrf2 expression: Lung, Breast, Colorectal, Prostrate.
Decreased Nrf2 expression: Skine, Liver, Pancreatic.
-Nrf2 is a cytoprotective transcription factor which demonstrated both a negative effect as well as a positive effect on cancer
- "promotes Nrf2 translocation from the cytoplasm to the nucleus," means facilitates the movement of Nrf2 into the nucleus, thereby enhancing the cell's antioxidant and cytoprotective responses. -Major regulator of Nrf2 activity in cells is the cytosolic inhibitor Keap1.

Nrf2 Inhibitors and Activators
Nrf2 Inhibitors: Brusatol, Luteolin, Trigonelline, VitC, Retinoic acid, Chrysin
Nrf2 Activators: SFN, OPZ EGCG, Resveratrol, DATS, CUR, CDDO, Api
- potent Nrf2 inducers from plants include sulforaphane, curcumin, EGCG, resveratrol, caffeic acid phenethyl ester, wasabi, cafestol and kahweol (coffee), cinnamon, ginger, garlic, lycopene, rosemany

Nrf2 plays dual roles in that it can protect normal tissues against oxidative damage and can act as an oncogenic protein in tumor tissue.
– In healthy tissues, NRF2 activation helps protect cells from oxidative damage and maintains cellular homeostasis.
– In many cancers, constitutive activation of NRF2 (often through mutations in NRF2 itself or loss-of-function mutations in KEAP1) leads to an enhanced antioxidant capacity.
– This upregulation can promote tumor cell survival by enabling cancer cells to thrive under oxidative stress, resist chemotherapeutic agents, and sustain metabolic reprogramming.
– Elevated NRF2 levels have been implicated in promoting tumor growth, metastasis, and resistance to therapy in various malignancies.
– High or sustained NRF2 activity is frequently associated with aggressive tumor phenotypes, poorer prognosis, and decreased overall survival in several cancer types.
– While its activation is essential for protecting normal cells from oxidative stress, aberrant or sustained NRF2 activation in tumor cells can lead to enhanced survival, therapeutic resistance, and tumor progression.

NRF2 inhibitors: (to decrease antioxidant defenses and increase cell death from ROS).
-Brusatol: most cited natural inhibitors of Nrf2.
-Luteolin: luteolin can reduce Nrf2 activity in specific cancer models and may enhance cell sensitivity to chemotherapy. However, luteolin is also known as an antioxidant, and its influence on Nrf2 can sometimes be context dependent.
-Apigenin: certain studies to down‑regulate Nrf2 in cancer cells: Dose and context dependent .
-Oridonin:
-Wogonin: although its effects might be cell‑ and dose‑specific.
- Withaferin A

Scientific Papers found: Click to Expand⟱
9191- ITCs,  AITC,  BITC,  PEITC,  SFN  Molecular Targets of Isothiocyanates in Cancer: Recent Advances
- Review, Var, NA
Risk↓, TumCG↓, ROS↑, TumCCA↑, Apoptosis↑, Ingr?, chemoPv↑, P450↓, SXR↓, CYP3A4↓, NRF2↑, ARE↑, HO-1↑, p38↓, TrxR↑, Trx↑, NF-kB↓, AP-1↓, BioAv↑, Akt↓, STAT3↓, HDAC↓, VEGF↓, MMP2↓, Hif1a↓, CD31/PECAM-1↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, FOXO1↓, FOXO3↓, BIM↑, p27/CDKN1B↑, P21↑, HER2/EBBR2↓, EGFR↓, Bcl-xL↓, XIAP↓, ROS↓, Zeb1↓, Snail↓, E-cadherin↑, MMP2↓, MMP9↓, ROS↑, MMP↓, Casp↑, DNAdam↑, TumCCA↑, γH2AX↑, CSCs↓, OCT4↓, SOX2↓, Nanog↓, NOTCH2↑, selectivity↝, ETC↓, compI↓, compIII↓, OCR↓, Synergy↑, ChemoSen↑, RadioS↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑,
7897- IVT,  VT,    Vitexin and isovitexin delayed ageing and enhanced stress-resistance through the activation of the SKN-1/Nrf2 signaling pathway
- in-vitro, Nor, NA
*antiOx↑, *ROS↓, *OS↑, *NRF2↑, *AntiAg↑,
7904- IVT,    Isovitexin alleviates myocardial oxidative stress injury in diabetic mice by enhancing myocardial SIRT3 expression and reducing oxidative stress
- in-vivo, Nor, NA
*cardioP↑, *IL1β↓, *IL6↓, *TNF-α↓, *NQO1↑, *NRF2↑, *SIRT3↑, *NOX2↓, *ROS↓,
7911- IVT,    Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study
- in-vitro, Arthritis, NA
*ECM/TCF↑, *Inflam↓, *NF-kB↓, *NRF2↑,
7890- IVT,    Isovitexin protects against cisplatin-induced kidney injury in mice through inhibiting inflammatory and oxidative responses
- in-vivo, Nor, NA
RenoP↑, *BUN↓, *creat↓, *TNF-α↓, *IL1β↓, *IL6↓, *MDA↓, *ROS↓, *NF-kB↓, *NRF2↑, *HO-1↑,
7888- IVT,    Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways
- vitro+vivo, Nor, NA
*Inflam↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Apoptosis↓, *p‑MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *ICAM-1↓, *VCAM-1↓, *MPO↓, *MDA↓, *GSH↑, *SOD↑,
5099- JG,    Juglone induces ferroptosis in glioblastoma cells by inhibiting the Nrf2-GPX4 axis through the phosphorylation of p38MAPK
- vitro+vivo, GBM, LN229 - vitro+vivo, GBM, T98G
Ferroptosis↑, p‑MAPK↑, NRF2↓, GPx4↓, TumPF↓, Apoptosis↑, ROS↑, GSH↓, lipid-P↑, Ki-67↓, TumCG↓,
8085- KAE,    Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, PI3K↓, Akt↓, STAT3↓, AP-1↓, NRF2↓, BioAv↑, Inflam↓, NF-kB↓, TNF-α↓, VEGF↓, BAX↑, Casp↑, Bcl-2↓, P53↑, PTEN↑, hTERT/TERT↓, NRF2↓, ROS↑, DR5↑, ERK↑, CHOP/DDIT3↑, DR4↑, JNK↑, Ki-67↓, ChemoSen↑,
8093- KAE,    Kaempferol inhibits Nrf2 signalling pathway via downregulation of Nrf2 mRNA and induces apoptosis in NSCLC cells
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H460
GSTA1↓, NQO1↓, HO-1↓, NRF2↓, ROS↑, Apoptosis↑,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8072- KAE,    Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation
- Review, CRC, NA
AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, Synergy↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,
8081- KAE,    The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer
- Review, BC, NA
*antiOx↓, *Inflam↓, *neuroP↓, *AntiCan↑, DNAdam↓, Casp3↑, Casp9↑, p‑AMT/GCST/T-protein↑, ROS↑, NRF2↑, Apoptosis↑, cl‑PARP↓, BAX↑, Bcl-2↓, TumCCA↓, angioG↓, MMP3↓, MMP9↓, ChemoSen↑, BioAv↓, Glycolysis↓, cl‑PARP↑, Ca+2↑, MMP↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, angioG↓, VEGF↓, Hif1a↓, chemoP↑, *ROS↓, NRF2↑, BioAv↑,
8054- KAE,    Kaempferol Improves Alzheimer's Disease by Inhibiting Neuronal Ferroptosis via Activating GPX4/AKR1C3 Signaling Pathway
- vitro+vivo, AD, NA
*AKR1B10↝, *MDA↓, *ROS↓, *GSH↑, *SOD↑, *GPx4↑, *NQO1↑, *xCT/SLC7A11↑, *NRF2↑, *HO-1↑, *cognitive↑, *Aβ↓, *p‑tau↓, *Ferroptosis↓, *AKR1C3/17β-HSD5/PGF Synthase↑, *AKR1B1/ALR2↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8056- KAE,    Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications
- Review, Var, NA - Review, Diabetic, NA
*antiOx↑, *ROS↓, *NRF2↑, *Inflam↓, *NF-kB↓, *MAPK↓, *STAT↓, *AntiDiabetic↑, *AMPK↑, *IRes↑, Apoptosis↑, TumCCA↑, TumMeta↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, *AntiBio↑, *hepatoP↑, *SIRT1↝, *BioAv↓,
8157- lamb,    Pinus koraiensis leaf extract and lambertianic acid attenuate fatigue and improve endurance capacity via PI3K-mediated regulation of oxidative stress and mitochondrial biogenesis
- in-vivo, Nor, NA
*fatigue↓, *ROS↓, *NF-kB↓, *IL6↓, *SOD↑, *PI3K↑, *NRF2↑, *HO-1↑, *SIRT1↑, *PGC-1α↑, *Nrf1↑, *Strength↑,
8169- Lap,    Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells
- in-vitro, Liver, HepG2
toxicity↑, mtDam↑, ROS↑, NRF2↑, GSH↑, GSSG↑, SOD2↑,
8237- LCA,    Role of Licochalcone A in Potential Pharmacological Therapy: A Review
- Review, Var, NA
*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑, *antiAll↑, *MUC5AC↓, *E-sel↓, *CCL11↓,
8246- LCA,    Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349
- in-vivo, Arthritis, NA
*AntiBio↑, *AntiTum↑, *Inflam↓, *AntiArt↑, *p62↑, *NRF2↑,
8245- LCA,    Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity
- in-vivo, LiverDam, NA
*hepatoP↑, *Apoptosis↓, *mtDam↓, *ROS↓, *NRF2↑, *Keap1↓, *ARE↑, *ALAT↓, *AST↓, *MDA↓, *MPO↓, *SOD↑, *GSH/GSSG↑, *Bcl-2↑, *BAX↓, *cl‑Casp3↓, *p‑cJun↓, *AIF↓, *Cyt‑c↓,
8242- LCA,    Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A
- in-vivo, LiverDam, NA
*ALAT↓, *AST↓, *Inflam↓, *ROS↓, *TLR4↓, *MAPK↓, *NF-kB↓, *TXNIP↓, *NLRP3↓, *NRF2↑, *p62↑, *hepatoP↑, *autophagy↑,
8207- LCA,    Licochalcone a Induces ROS-Mediated Apoptosis through TrxR1 Inactivation in Colorectal Cancer Cells
- in-vitro, CRC, HCT116
ROS↑, TumCCA↑, Apoptosis↑, eff↓, TrxR1↓, cDC2↓, Bcl-2↓, BAX↑, NRF2↓, p‑ASK1↑,
8219- LCA,    Licochalcone A Ameliorates Cognitive Dysfunction in an Alzheimer's Disease Model by Inhibiting Endoplasmic Reticulum Stress-Mediated Apoptosis
- in-vivo, AD, NA
*Dose↝, *cognitive↑, *Aβ↓, *ER Stress↓, *BioAv↑, *toxicity↓, *PERK↓, *eIF2α↓, *ATF4↓, *CHOP/DDIT3↓, *NRF2↑,
8229- LCA,    Licochalcone A: a review of its pharmacology activities and molecular mechanisms
- Review, Nor, NA
*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,
8234- LCA,    Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment
- Review, AD, NA
*neuroP↑, *PTP1B↓, *cognitive↑, *BDNF↑, *TrkB↝, *cJun↓, *p‑tau↓, *AChE↓, *Ach↑, *Aβ↓, *antiOx↑, *NRF2↑, *AntiViral↑, *Obesity↓, *PI3K↑, *Akt↑, *mTOR↑, *memory↑, *BBB↑,
8230- LCA,    The Ameliorative Role of Lico A on Aflatoxin B1-Triggered Hepatotoxicity Partially by Activating Nrf2 Signal Pathway
- vitro+vivo, Nor, NA
*hepatoP↑, *ROS↓, *TLR4↓, *NF-kB↓, *MAPK↓, *NLRP3↓, *NRF2↑, *Inflam↓, *Pyro↓,
8222- LCA,    Licochalcone A Induces Cholangiocarcinoma Cell Death Via Suppression of Nrf2 and NF-κB Signaling Pathways
- in-vitro, CCA, KKU-100 - in-vitro, CCA, KKU-213 - in-vitro, CCA, KKU-214 - in-vitro, CCA, KKU-156 - in-vitro, 0-Reserved, KKU-452
TumCP?, TumCD?, ROS↑, NRF2↓, BAX↑, Cyt‑c↑, TumCMig↓, TumCCA↑, NF-kB↓, STAT3↓, cycD1/CCND1↓, VEGF↓, ICAM-1↓,
8225- LCA,  Cisplatin,    Licochalcone A protects against cisplatin-induced acute kidney injury via the modulation of Nrf2/Keap1-mediated ferroptosis and apoptosis
- in-vivo, Nor, NA
*RenoP↑, *Urea↓, *BUN↓, *creat↓, *Apoptosis↓, *Ferroptosis↓, *Iron↓, *ROS↓, *lipid-P↓, *mtDam↓, *NRF2↑,
8224- LCA,    3,3',4,4'-Tetrahydroxy-2-methoxychalcone from Glycyrrhiza uralensis roots inhibits HIF-1α and Nrf2, suppressing hypoxia-induced angiogenesis
- in-vitro, CRC, HCT116
Hif1a↓, NRF2↓, VEGF↓, HO-1↓, ROS↓,
8223- LCA,    Lico A Enhances Nrf2-Mediated Defense Mechanisms against t-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells
- in-vitro, Nor, RAW264.7
*Apoptosis↓, *ROS↓, *GSH↑, *GCLM↑, *GCLC↑, *HO-1↑, *NRF2↑, *Keap1↓, *ARE↑, *Akt↑, *ERK↑, *PI3K↑,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8277- LE,    Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights
- Review, Var, NA
*antiOx↑, *AntiTum↑, HMGB1↓, COX2/PTGS2↓, PGE2↓, TumCP↓, TumCCA↑, Synergy↑, MMP↓, p‑P53↑, BAX↑, cl‑PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, ROS↑, TumAuto↑, MMP9↓, TumMeta↓, PI3K↓, Akt↓, eff↑, *chemoP↑, *NRF2↑, *NF-kB↓,
8329- LIN,    Microglial-targeting induced by intranasal linalool during neurological protection postischemia
- in-vivo, Stroke, NA - in-vivo, AD, NA
*Stroke↓, *BioAv↑, *neuroP↑, *motorD↑, *Learn↑, *COX2/PTGS2↓, *IL1β↓, *NRF2↑, *Dose↝, *cognitive↑,
8327- LIN,    Recent updates on bioactive properties of linalool
- Review, Var, NA
*AntiCan↑, *AntiBio↑, *neuroP↑, *Stress↓, *hepatoP↑, *RenoP↑, *ROS↓, ROS↑, *Inflam↓, *toxicity↓, TumCP↓, TumCCA↑, mtDam↑, MMP↓, compI↓, compII↓, ETC↓, ATP↓, angioG↓, ChemoSen↑, *GSH↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ALAT↓, *AST↓, chemoP↑,
8320- LIN,    Ameliorative Effect of Linalool in Cisplatin-Induced Nephrotoxicity: The Role of HMGB1/TLR4/NF-κB and Nrf2/HO1 Pathways
- in-vivo, Nor, NA
RenoP↑, Dose↝, *TLR4↓, *MyD88↓, *TRIF↓, *TNF-α↓, *IL1β↓, *IL6↓, *NF-kB↓, *chemoP↑, *Casp3↓, *Casp9↓, *BAX↓, *Bcl-2↑, ChemoSen↑, *cardioP?, *hepatoP↑, *Apoptosis↓, *antiOx↑, *Inflam↓, *ROS↓, *BUN?, *creat↓, *GSH↑, *SOD↑, *Catalase↑, *MDA↓, *NADPH↓, *NRF2↑, *HO-1↑,
8382- LT,    Luteolin as a dietary flavonoid for brain health: modulating neuroinflammation and cognitive decline in neurodegenerative disorders
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *antiOx↑, *NF-kB↓, *NRF2↑, *BDNF↑, *cognitive↑, *motorD↑, *BBB↑, *BioAv↓, *NO↓, *ROS↓, *NRF2↑, *ARE↑, *MMP↑, *BDNF↑, *Learn↑, *memory↑, *cognitive↑, *p‑JNK↓, *GFAP↓, *AIF1/Iba-1↓, *TNF-α↓, *IL1β↓, *BAX↓, *COX2/PTGS2↓, *BACE/β-secretase↓, *Aβ42↓, *PSD95↑, *SNAP25↑, *lipid-P↓, *GSTs↓, *GSH↑, *SOD↓, *Catalase↓, *AChE↓, *Casp3↓, *Casp9↓,
8379- LT,    Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *ROS↓, *Apoptosis↓, *BioAv↓, *BBB∅, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, *Aβ↓, *memory↑, *neuroG↑, *NRF2↑, *NLRP3↓, *ROS↓, JAK2↓, STAT3↓, PD-L1↓, Perforin↝, GranB/GZMB↝, hepatoP↑, *Learn↑, *TNF-α↓, *IL1β↓, *IL6↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *ER Stress↓, *GRP78/BiP↓, *IRE1↓, *cognitive↑, *BAX↓, *Bcl-2↓, *Casp3↓, *PSD95↑, *SNAP25↑, *JNK↓, *eff↑, *mtDam↓, *MMP↑, *Stroke↓, *TJ↑, *MMP9↓, *BBB∅, *NeuroI↓,
8378- LT,    Luteolin and its derivatives: modulation of epithelial-mesenchymal transition in fibrosis and cancer
- Review, Var, NA
EMT↓, TGF-β1↓, Smad1↓, PI3K↓, Akt↓, Hippo↝, YAP/TEAD↓, *NRF2↑, *HO-1↑, *ROS↓, E-cadherin↑, ZO-1↑, Vim↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, TCF↓, Zeb1↓, angioG↓, eff↑, ROS↑, mtDam↑, MMP↓, ETC↓,
8389- LT,    Luteolin-Manganese Nanozyme Induces Apoptosis and Ferroptosis for Enhanced Cancer Therapy
- in-vitro, Var, NA
ROS↑, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Ferroptosis↑, NRF2↓, GPx4↓, IronCh↑,
8390- LT,    Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective
- Review, IBD, NA - Review, CRC, NA
*Diff↝, *Inflam↓, *ROS↓, *GutMicro↑, *IBI↑, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, *BioAv↑, *iNOS↓, *TNF-α↓, *IL6↓, *MDA↓, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *Catalase↑, *5HT↓, *TPH1↓, *MAPK↓, *ERK↓, *Inflam↓, cycD1/CCND1↓, CDK4↓, TumCCA↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, E-cadherin↑, N-cadherin↓, Vim↓,
8394- LT,    Luteolin prevents THP-1 macrophage pyroptosis by suppressing ROS production via Nrf2 activation
- in-vitro, Nor, NA
*Pyro↓, *NLRP3↓, *proCasp1↓, *Casp1↓, *NRF2↑, *HO-1↑, *ROS↓,
8401- LT,    Multi-Faceted Role of Luteolin in Cancer Metastasis: EMT, Angiogenesis, ECM Degradation and Apoptosis
- Review, Var, NA
EMT↓, N-cadherin↓, Vim↓, VEGF↓, VEGFR1↓, MMPs↓, Telomerase↓, NF-kB↓, cMyc↓, Bax:Bcl2↑, Casp3↑, PI3K↓, Akt↓, FOXO3↑, P21↑, p27/CDKN1B↑, cl‑PARP↑, Cyt‑c↑, NOTCH↓, HES1↓, ROS↑, SOD↓, miR-34b-5p↑, Hif1a↓, P21↓, survivin↓, Mcl-1?, Bcl-xL↓, MDM2↓, MMP2↓, MMP9↓, MMP3↓, MMP16↓, miR-384↑, NRF2↓, HO-1↓, angioG↓,
8399- LT,    Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ-dependent mechanism in Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *cognitive↑, *neuroP↑, *Aβ↓, *mtDam↓, *Apoptosis↓, *PPARγ↑, *ROS↓, *SOD↑, *GSH↑, *NRF2↑, *MFN2↑, *DRP1/DNM1L↓, *FIS1↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *cl‑Casp9↓, *cl‑Casp3↓, *IDE↑, *BACE/β-secretase↓, *Aβ42↓,
8398- LT,    Luteolin: Nature's promising warrior against Alzheimer's and Parkinson's disease
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *AntiBio↑, *AntiCan↑, *hepatoP↑, *neuroP↑, *cardioP↑, *neuroG↑, *BBB↑, *ROS↓, *AChE↓, *p‑T-cadherin↓, *Aβ↓, *memory↑, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *RANTES↓, *BioAv↑, *Half-Life↝, *toxicity↓, *BACE/β-secretase↓, *Aβ42↓, *COX2/PTGS2↓, *Bcl-2↓, *Casp3↓, *BAX↓, *GSTs↓, *lipid-P↓, *Casp3↓, *Casp9↓, *memory↑, *GSK‐3β↓, *ChAT↑, *SOD↑, *GPx↑, *MDA↓, *ER Stress↓, *GRP78/BiP↓, *NRF2↑, *motorD↑, *antiAll↑,
2589- LT,  Chemo,    Luteolin Inhibits Breast Cancer Stemness and Enhances Chemosensitivity through the Nrf2-Mediated Pathway
- in-vitro, BC, MDA-MB-231
NRF2↓, HO-1↓, ChemoSen↑, CSCs↓, SIRT1↓,
2588- LT,  Chemo,    Luteolin sensitizes two oxaliplatin-resistant colorectal cancer cell lines to chemotherapeutic drugs via inhibition of the Nrf2 pathway
- in-vitro, CRC, HCT116
NRF2↓, NQO1↓, HO-1↓, GSH↓, ChemoSen↑,
2587- LT,    Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs
- in-vitro, Lung, A549
NRF2↓, GSH↓, ChemoSen↑, HO-1↓,
2930- LT,    Luteolin confers renoprotection against ischemia–reperfusion injury via involving Nrf2 pathway and regulating miR320
- in-vitro, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *NRF2↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,

Showing Research Papers: 351 to 400 of 687
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 687

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6,   antiOx↑, 9,   ARE↓, 1,   ARE↑, 2,   ARE/EpRE↑, 1,   Catalase↓, 13,   Catalase↑, 11,   Copper↑, 1,   Fenton↑, 5,   frataxin↑, 1,   GCLC↑, 2,   GCLM↑, 2,   GPx↓, 4,   GPx↑, 7,   GPx1↓, 2,   GPx1⇅, 1,   GPx4↓, 30,   GSH↓, 47,   GSH↑, 12,   i-GSH↓, 1,   GSH/GSSG↓, 5,   GSR↓, 2,   GSR↑, 3,   GSS↑, 1,   GSSG↑, 3,   GSTs↓, 2,   GSTs↑, 5,   GSTs↝, 1,   H2O2↓, 3,   H2O2↑, 4,   HO-1↓, 33,   HO-1↑, 51,   HO-1⇅, 1,   Iron↓, 1,   Iron↑, 19,   i-Iron↓, 1,   i-Iron↑, 3,   Keap1↓, 6,   Keap1↑, 4,   Keap1↝, 2,   ox-Keap1↓, 1,   rd-Keap1↑, 1,   lipid-P↓, 1,   lipid-P↑, 23,   MDA↓, 5,   MDA↑, 20,   i-MDA↑, 1,   MPO↓, 2,   NADH↓, 1,   NFE2L2↑, 1,   NOX↓, 1,   NOX↑, 1,   NOX4↓, 1,   NOX4↑, 2,   NQO1↓, 8,   NQO1↑, 16,   NRF2↓, 119,   NRF2↑, 129,   NRF2⇅, 4,   NRF2↝, 7,   NRF2∅, 3,   p‑NRF2↓, 2,   p‑NRF2↑, 2,   Prx↓, 1,   Prx↑, 1,   Prx4↑, 1,   PrxI↓, 1,   RNS↓, 1,   ROS?, 2,   ROS↓, 40,   ROS↑, 204,   ROS⇅, 5,   ROS↝, 2,   ROS∅, 2,   i-ROS↑, 1,   mt-ROS↓, 1,   mt-ROS↑, 2,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 11,   SOD↑, 15,   SOD1↓, 1,   SOD1↑, 4,   SOD2↓, 8,   SOD2↑, 3,   T-SOD↓, 1,   Trx↓, 3,   Trx↑, 3,   Trx1↑, 1,   ox-Trx1↑, 1,   TrxR↓, 7,   TrxR↑, 1,   TrxR1↓, 3,   TrxR1↑, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 9,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↓, 2,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 1,   Mets↑, 1,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 5,   CDC25↓, 5,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   EGF↓, 2,   ETC↓, 5,   MFN2↑, 1,   mitResp↓, 2,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↑, 14,   OCR↓, 1,   OCR↑, 1,   OXPHOS↓, 4,   OXPHOS↑, 1,   mt-OXPHOS↓, 1,   PDH↓, 1,   PGC-1α↑, 1,   SDH↓, 1,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↑, 1,   ACC-α↓, 1,   ACC1↓, 2,   ACLY↓, 2,   ACSL4↑, 2,   ALAT↓, 3,   AMPK↑, 17,   p‑AMPK↑, 1,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 12,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 2,   ECAR↓, 1,   ENO1↓, 1,   FASN↓, 5,   G6PD↓, 1,   GLS↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 7,   GlutMet↓, 2,   Glycolysis↓, 24,   GSK‐3β↓, 8,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 4,   H2S↑, 1,   HK2↓, 13,   lactateProd↓, 6,   lactateProd↑, 1,   LDHA↓, 5,   LDL↓, 1,   MCT4↓, 1,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 4,   NADPH↑, 6,   PCK1↓, 1,   PDK1 / PDPK1↓, 7,   PDK3↑, 1,   PFK↓, 1,   PKM2↓, 5,   PKM2↑, 1,   PPP↑, 1,   Pyruv↓, 1,   SCD1↓, 2,   SIRT1↓, 3,   SIRT1↑, 6,   SLC1A5↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 4,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 3,   Apoptosis?, 2,   Apoptosis↓, 3,   Apoptosis↑, 123,   Apoptosis↝, 1,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   p‑ASK1↑, 1,   BAD↑, 3,   Bak↑, 3,   BAX↓, 4,   BAX↑, 63,   BAX↝, 2,   Bax:Bcl2↑, 13,   Bcl-2↓, 61,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-xL↓, 11,   Bcl-xL↝, 1,   BID↑, 4,   BIM↑, 6,   BNIP3↑, 2,   Casp↑, 20,   Casp↝, 1,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   cl‑Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 3,   Casp3↓, 2,   Casp3↑, 66,   Casp3↝, 1,   cl‑Casp3↑, 12,   cl‑Casp3⇅, 1,   proCasp3↑, 3,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 16,   Casp8∅, 2,   cl‑Casp8↑, 1,   proCasp8↑, 1,   Casp9↑, 44,   cl‑Casp9↑, 9,   proCasp9↓, 1,   proCasp9↑, 1,   cFLIP↓, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 55,   Cyt‑c↝, 1,   Diablo↑, 5,   DR5↓, 1,   DR5↑, 20,   Fas↑, 11,   FasL↑, 5,   Ferroptosis↑, 38,   GranB/GZMB↝, 1,   GSDMD↑, 2,   GSDME-N↑, 1,   HEY1↓, 1,   IAP1↓, 4,   IAP1↑, 1,   IAP2/BIRC3↓, 3,   ICAD↑, 1,   iNOS↓, 12,   Mcl-1?, 1,   Mcl-1↓, 8,   Mcl-1↑, 1,   MDM2↓, 8,   p‑MDM2↓, 1,   MOMP↑, 4,   Necroptosis↑, 1,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 5,   p38↑, 11,   p‑p38↓, 2,   p‑p38↑, 3,   Perforin↝, 1,   PUMA↑, 2,   Pyro↑, 4,   RIP3↑, 1,   survivin↓, 27,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAILR↑, 2,   TumCD?, 1,   TumCD↓, 1,   TumCD↑, 8,   XIAP↓, 16,   XIAP↑, 1,   YAP/TEAD↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 93,   Akt↑, 3,   Akt↝, 2,   p‑Akt↓, 24,   p‑Akt↑, 1,   AKT1↓, 2,   Akt2↓, 1,   AMPKα↑, 1,   BRAF↝, 1,   p‑CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 3,   cMET↓, 2,   p‑cMET↑, 1,   p‑CREB↑, 1,   EF-1α↓, 1,   EGFR↓, 27,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 22,   ERK↑, 6,   p‑ERK↓, 4,   p‑ERK↑, 3,   ERK5↓, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↝, 1,   HRAS↓, 1,   IKKα↓, 5,   IR↓, 1,   IκB↓, 2,   JAK↓, 3,   JAK↝, 1,   JAK1↓, 2,   JAK2↓, 6,   JNK↓, 2,   JNK↑, 14,   JNK↝, 1,   p‑JNK↑, 4,   MAP2K1/MEK1↓, 1,   MAPK↓, 16,   MAPK↑, 17,   MAPK↝, 3,   p‑MAPK↑, 2,   MARK4↓, 1,   p‑MEK↓, 1,   MKK4↓, 1,   mTOR↓, 58,   mTOR↑, 1,   mTOR↝, 3,   p‑mTOR↓, 7,   p‑mTOR↑, 1,   mTORC2↓, 1,   p70S6↓, 2,   P70S6K↓, 4,   P70S6K↑, 1,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PAK↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 73,   PI3K↑, 4,   PI3K↝, 3,   p‑PI3K↓, 6,   p‑PI3K↑, 1,   PI3K/Akt↓, 1,   PI3K/Akt↝, 1,   PKCδ↓, 6,   PKCδ↑, 1,   PTEN↓, 3,   PTEN↑, 15,   PTEN↝, 2,   Raf↓, 2,   c-Raf↓, 1,   RAS↓, 7,   RAS↑, 1,   RET↓, 1,   RIP1↓, 1,   RIP1↑, 1,   SHP1↑, 1,   Sp1/3/4↓, 10,   Src↓, 1,   p‑Src↓, 1,   STAT↓, 2,   STAT3↓, 53,   STAT3↑, 1,   p‑STAT3↓, 6,   STAT4↓, 1,   STAT5↓, 1,   STAT6↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 9,   ATF4↝, 1,   ATFs↑, 1,   cJun↓, 4,   cJun↑, 1,   cMyc↓, 24,   p‑cMyc↑, 1,   DNMT1↓, 8,   DNMT3A↓, 4,   DNMT3B↓, 1,   DNMTs↓, 11,   EZH2↓, 1,   FOXM1↓, 2,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 5,   p‑FOXO3↓, 3,   FOXO4↓, 1,   H3↓, 1,   H3↑, 2,   p‑H3↓, 1,   ac‑H3↓, 1,   ac‑H3↑, 2,   H4↓, 1,   H4↑, 1,   ac‑H4↓, 1,   ac‑H4↑, 2,   HATs↓, 3,   HATs↑, 1,   HDAC↓, 29,   HDAC↑, 1,   HDAC1↓, 6,   HDAC2↓, 6,   HDAC3↓, 6,   HDAC4↓, 1,   HDAC6↓, 1,   HDAC8↓, 3,   HES1↓, 1,   HMTs↓, 1,   KLF4↓, 1,   miR-124-3p↓, 1,   miR-133a-3p↑, 1,   miR-140↑, 1,   miR-155↓, 2,   miR-19b↓, 1,   miR-200c↑, 2,   miR-206↑, 1,   miR-21↓, 1,   miR-21↑, 1,   miR-25-5p↓, 1,   miR-29b↓, 1,   miR-30a-5p↑, 1,   miR-34a↓, 1,   miR-34a↑, 3,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-590-3p↑, 1,   Myc↓, 2,   OCT4↓, 11,   other?, 1,   other↓, 3,   other↑, 5,   other⇅, 1,   other↝, 9,   PhotoS↑, 1,   RUNX2↓, 1,   SOX2↓, 8,   SOX4↓, 2,   SOX4↑, 1,   SOX9↓, 2,   TET3↑, 1,   tumCV?, 1,   tumCV↓, 32,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 4,   CHOP/DDIT3↑, 22,   cl‑CHOP/DDIT3↑, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 5,   p‑eIF2α↑, 4,   ER Stress↑, 37,   GRP78/BiP↑, 9,   GRP94↑, 1,   HSP27↓, 4,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP72↓, 1,   HSP90↓, 11,   ac‑HSP90↑, 1,   HSPs↑, 1,   IRE1↑, 2,   NQO2↑, 1,   PERK↑, 7,   p‑PERK↑, 1,   UPR↑, 10,   XBP-1↓, 2,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 9,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3A↑, 1,   LC3B-II↑, 2,   LC3II↑, 3,   LC3s↑, 1,   p62↓, 6,   p62↑, 3,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 20,  

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1,   ATM↑, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 3,   DNAdam↑, 28,   DNAdam⇅, 1,   DNArepair↓, 1,   m-FAM72A↓, 1,   FEN1↓, 1,   hTERT/TERT↓, 10,   MGMT↓, 1,   P53?, 1,   P53↓, 4,   P53↑, 62,   P53↝, 3,   p‑P53↑, 3,   PARP↓, 4,   PARP↑, 10,   cl‑PARP↓, 2,   cl‑PARP↑, 37,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 18,   POLD1↓, 1,   SIRT6↓, 2,   Telomerase↓, 8,   TOP1↓, 2,   TOP2↓, 3,   γH2AX↑, 2,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 14,   CDK1↑, 4,   CDK2↓, 28,   CDK2↑, 2,   CDK4↓, 28,   CDK6↓, 10,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 2,   CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 7,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 14,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 40,   cycD1/CCND1↑, 2,   cycD1/CCND1↝, 1,   CycD3↓, 1,   CycD3↑, 1,   cycE/CCNE↓, 12,   cycE/CCNE↑, 2,   Ki-67↓, 15,   mitA↑, 1,   p19↑, 1,   P21?, 1,   P21↓, 4,   P21↑, 44,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 16,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 1,   p‑RB1↓, 5,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 2,   TumCCA↑, 112,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 2,   ALDH1A1↓, 2,   BMI1↓, 2,   BMP7/OP1↓, 1,   BMPs↑, 3,   CD133↓, 4,   CD133↑, 1,   CD34↓, 1,   cFos↓, 4,   cFos↑, 1,   cMYB↓, 2,   CSCs?, 1,   CSCs↓, 25,   Diff↑, 2,   EP4/PTGER4↑, 1,   FGF↓, 2,   Gli↓, 2,   Gli1↓, 4,   HH↓, 3,   IGF-1?, 1,   IGF-1↓, 6,   IGFBP3↑, 1,   Ki-67↓, 15,   Let-7↑, 1,   mTORC1↓, 4,   Nanog↓, 10,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 10,   NOTCH↑, 1,   NOTCH1↓, 8,   NOTCH1↑, 3,   NOTCH2↑, 1,   NOTCH3↓, 2,   SCF↓, 1,   Shh↓, 5,   Smo↓, 3,   STAT1↓, 3,   TAZ↓, 1,   TumCG↓, 42,   TumCG↑, 1,   TumCP?, 1,   TumCP↓, 88,   TumCP↑, 4,   Wnt↓, 27,   Wnt↝, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   annexin II↓, 1,   AP-1↓, 9,   AP-1↑, 2,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 1,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↓, 1,   Ca+2↑, 15,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal1↑, 1,   cal2↑, 1,   Cdc42↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 4,   E-cadherin↑, 26,   EMT↓, 52,   EMT↝, 1,   FAK↓, 12,   FAK↑, 1,   p‑FAK↓, 2,   Fibronectin↓, 3,   ITGA5↓, 1,   ITGB1↓, 3,   ITGB3↓, 2,   KRAS↓, 2,   LAMs↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MET↓, 3,   MET↑, 3,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 5,   MMP13↓, 3,   MMP16↓, 1,   MMP2↓, 45,   MMP2↑, 1,   MMP2⇅, 1,   MMP2↝, 1,   MMP3↓, 7,   MMP7↓, 9,   MMP9↓, 51,   MMP9↑, 2,   MMP9⇅, 1,   MMPs↓, 22,   N-cadherin↓, 20,   NFAT↑, 1,   PDGF↓, 3,   Rac1↓, 1,   Rho↓, 3,   Rho↑, 1,   ROCK1↓, 6,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 7,   Smad1↓, 2,   Smad1↑, 2,   SMAD2↓, 1,   SMAD3↓, 1,   SMAD4↓, 1,   Snail?, 1,   Snail↓, 17,   TET1↓, 1,   TET1↑, 5,   TGF-β↓, 9,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 3,   TIMP2↓, 3,   TIMP2↑, 2,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↓, 2,   TumCI↓, 54,   TumCMig↓, 47,   TumMeta↓, 37,   TumMeta↑, 3,   TumPF↓, 1,   Twist↓, 13,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 18,   uPAR↓, 1,   Vim?, 1,   Vim↓, 24,   Vim↑, 1,   Zeb1↓, 7,   α-SMA↓, 1,   β-catenin/ZEB1↓, 31,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 56,   CD31/PECAM-1↓, 2,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 54,   LOX1↓, 1,   NO↓, 4,   NO↑, 1,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 73,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   CLDN1↓, 3,   CX43/GJA1↓, 1,   EPR↑, 1,   GLUT1↓, 6,   GLUT4↓, 1,   MMP↓, 60,   MMP↑, 2,   MPT↑, 1,   TRPV1↓, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD25+↑, 1,   CD4+↑, 1,   CD44↓, 8,   CD47↓, 1,   CD8+↑, 3,   cDC2↓, 2,   COX1↓, 2,   COX2/PTGS2↓, 45,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCc↓, 1,   CXCR2↓, 1,   CXCR3↓, 1,   CXCR4↓, 6,   DR4↑, 6,   Eos↑, 1,   FOXP3↑, 2,   Gal-3↓, 1,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 8,   IFN-γ↓, 4,   IFN-γ↑, 1,   IL1↓, 6,   IL10↓, 2,   IL10↑, 1,   IL12↓, 2,   IL18↓, 1,   IL1β↓, 13,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 4,   IL4↓, 2,   IL4↑, 1,   IL5↓, 1,   IL6↓, 31,   IL6↑, 1,   IL6↝, 1,   IL8↓, 10,   IL8↑, 1,   Imm↑, 6,   Imm↝, 2,   INF-γ↑, 1,   Inflam↓, 19,   Inflam↑, 1,   M1↓, 1,   M2 MC↓, 2,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   NAF1↓, 3,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 99,   NF-kB↑, 4,   NF-kB↝, 3,   p‑NF-kB↑, 1,   NK cell↑, 5,   NK cell⇅, 1,   NLRP3↓, 3,   NLRP3↑, 5,   p65↓, 5,   p‑p65↓, 2,   PD-1↓, 3,   PD-L1↓, 9,   PGE2↓, 13,   PSA↓, 7,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 1,   T-Cell↑, 2,   TCF↓, 2,   Th1 response↑, 2,   Th2↑, 1,   TLR1↑, 1,   TLR4↓, 4,   TLR4↝, 1,   TNF-α↓, 23,   TNF-α↑, 1,   TNF-α↝, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   GGT/CD224↑, 1,   pH↝, 1,   pH∅, 1,   e-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   PRNP↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACTH↓, 1,   AhR↓, 2,   AhR↓, 1,   AR↓, 8,   AR↝, 1,   COMT↑, 1,   CYP19↓, 1,   ER-α36↓, 4,   ER(estro)↓, 1,   Estro↝, 1,   FGF21↓, 1,   GR↓, 1,   GR↑, 1,   PPARα↓, 1,   PPARγ↓, 3,   PPARγ↑, 4,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 26,   BioAv↑, 28,   BioAv↝, 9,   BioEnh?, 1,   BioEnh↑, 2,   chemoR↓, 1,   ChemoSen?, 1,   ChemoSen↓, 2,   ChemoSen↑, 118,   ChemoSen⇅, 1,   CYP1A1↓, 3,   CYP1A2↓, 1,   CYP1B1↓, 1,   CYP3A4↓, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 5,   Dose↝, 26,   Dose∅, 2,   eff↓, 24,   eff↑, 47,   eff↝, 8,   eff∅, 1,   GSTA1↓, 2,   GSTA1↑, 1,   GSTP1/GSTπ↓, 1,   GSTP1/GSTπ↑, 1,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 9,   MDR1↓, 6,   MRP1/ABCC1↓, 4,   P-gp/ABCB1↓, 10,   P-gp/ABCB1↑, 1,   P450↓, 3,   P450↝, 1,   RadioS↓, 2,   RadioS↑, 36,   selectivity?, 1,   selectivity↑, 45,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 76,   TET2↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 3,   ALP↓, 2,   AR↓, 8,   AR↝, 1,   AST↓, 2,   BP↓, 1,   BRAF↝, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 27,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   EZH2↓, 1,   Ferritin↑, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 10,   IL6↓, 31,   IL6↑, 1,   IL6↝, 1,   KRAS↓, 2,   LDH↓, 2,   LDH↑, 1,   Myc↓, 2,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 9,   PSA↓, 7,   PSA↝, 1,   PSA∅, 1,   PSADT↑, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan?, 1,   AntiCan↓, 1,   AntiCan↑, 30,   AntiCan∅, 2,   antiNeop↑, 2,   AntiTum↑, 18,   Appetite↑, 1,   cachexia↓, 1,   cardioP↑, 7,   CardioT↓, 2,   chemoP↑, 31,   chemoPv↑, 15,   ChemoSideEff↓, 5,   cognitive↑, 3,   fatigue↓, 1,   hepatoP↑, 6,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 14,   NP/CIPN↓, 2,   OS↓, 1,   OS↑, 8,   Pain↓, 3,   PFS↑, 1,   QoL↑, 5,   radioP↑, 13,   Remission↑, 1,   RenoP↑, 9,   Risk↓, 12,   Risk↑, 1,   Sleep↑, 2,   toxicity↓, 11,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 8,   TumW↓, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiBio↑, 1,   Bacteria↓, 2,   GutMicro↑, 6,   GutMicro↝, 1,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 3,  
Total Targets: 984

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 3,   antiOx?, 1,   antiOx↓, 6,   antiOx↑, 194,   ARE↓, 1,   ARE↑, 15,   ARE↝, 1,   Bil↓, 1,   Bil↑, 2,   Catalase↓, 1,   Catalase↑, 115,   Catalase↝, 1,   DUOX1↓, 1,   Fenton↓, 3,   GCLC↑, 6,   GCLC↝, 1,   GCLM↑, 5,   GCLM↝, 1,   GPx↓, 2,   GPx↑, 82,   GPx↝, 1,   GPx1↑, 3,   GPx4↓, 2,   GPx4↑, 12,   GPx4∅, 1,   GSH↓, 4,   GSH↑, 143,   GSH/GSSG↓, 1,   GSH/GSSG↑, 3,   GSR↓, 2,   GSR↑, 11,   GSS↑, 2,   GSSG↓, 1,   GSTs↓, 4,   GSTs↑, 18,   H2O2↓, 11,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 2,   HNE↓, 1,   HNE↑, 1,   HO-1?, 2,   HO-1↓, 5,   HO-1↑, 208,   HO-1⇅, 1,   HO-1↝, 1,   HO-1∅, 1,   HO-2↓, 1,   hyperG↓, 1,   hyperG↝, 1,   Iron↓, 4,   Iron↝, 1,   i-Iron↓, 3,   Keap1↓, 23,   Keap1↑, 1,   Keap1↝, 2,   ox-Keap1↑, 1,   lipid-P↓, 81,   lipid-P↑, 4,   mt-lipid-P↓, 1,   MDA↓, 120,   MDA↑, 2,   MPO↓, 20,   MPO↑, 1,   NOX↓, 3,   NOX1↓, 1,   NOX2↓, 3,   NOX4↓, 7,   NQO1↑, 56,   NQO1↝, 2,   Nrf1↑, 3,   NRF2?, 1,   NRF2↓, 18,   NRF2↑, 440,   NRF2⇅, 1,   NRF2↝, 2,   NRF2∅, 2,   p‑NRF2↑, 2,   ONOO↓, 1,   Prx↑, 4,   RNS↓, 4,   ROS?, 1,   ROS↓, 324,   ROS↑, 11,   ROS⇅, 4,   ROS∅, 3,   i-ROS↑, 1,   mt-ROS?, 1,   mt-ROS↓, 2,   selenoP↑, 1,   SOD?, 1,   SOD↓, 2,   SOD↑, 167,   SOD↝, 1,   SOD1↑, 11,   SOD2↓, 1,   SOD2↑, 7,   TAC↑, 25,   TBARS↓, 6,   Thiols↑, 1,   TOS↓, 1,   Trx↓, 1,   Trx↑, 7,   Trx1↑, 6,   TrxR↑, 3,   TrxR1↑, 3,   UCPs↑, 1,   uricA↓, 3,   VitC↑, 4,   VitE↓, 1,   VitE↑, 3,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 2,   FTH1↓, 1,   FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 16,   Mets↝, 1,   NCOA4↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 3,   EGF↓, 1,   FIS1↓, 1,   Insulin↑, 1,   MFN2↑, 2,   mitResp↑, 2,   mtDam↓, 17,   mtDam↑, 1,   NGB↑, 1,   OCR↑, 1,   PDH↑, 1,   PGC-1α↑, 9,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 2,   SIRT3↑, 4,   TFAM↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   3MST/MPST↑, 1,   5LO↓, 5,   ACC↓, 1,   Acetyl-CoA↑, 1,   ACSL4↓, 3,   ACSL4∅, 1,   ALAT↓, 32,   ALDOC↑, 1,   AMPK↓, 2,   AMPK↑, 26,   p‑AMPK↑, 3,   ATP↓, 1,   ATP↑, 15,   Buty↑, 1,   cAMP↑, 3,   CBS↑, 1,   CRM↑, 3,   cytoP450↓, 1,   DGAT1↓, 1,   FABP4↓, 1,   FAO↓, 1,   FASN↓, 3,   G6PD↑, 2,   GAPDH↑, 1,   glucose↓, 4,   glucose↑, 2,   glucose↝, 2,   GlucoseCon↓, 1,   GlucoseCon↑, 6,   Glycolysis↑, 3,   GSK‐3β↓, 24,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 6,   H2S↑, 3,   HK2↓, 1,   HK2↑, 2,   HMG-CoA↓, 1,   LDHA↓, 1,   LDL↓, 12,   lipidLev↓, 1,   lipoGen↓, 1,   NAD↓, 1,   NAD↑, 1,   NADH:NAD↑, 1,   NADPH↓, 11,   NADPH↑, 9,   NADPH∅, 1,   PDKs↓, 1,   PFK↓, 1,   PFK↑, 1,   PKM2↓, 2,   PKM2↑, 1,   PONs↑, 1,   SCFAs↑, 2,   SIRT1↓, 2,   SIRT1↑, 24,   SIRT1↝, 1,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↓, 4,   Apoptosis↓, 47,   Apoptosis↑, 2,   ASC↓, 1,   ASK1↓, 1,   BAX↓, 23,   BAX↑, 3,   Bax:Bcl2↓, 7,   Bcl-2↓, 4,   Bcl-2↑, 20,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp↓, 1,   Casp1↓, 4,   proCasp1↓, 1,   Casp12↓, 2,   Casp3?, 1,   Casp3↓, 39,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 9,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 12,   Casp9↑, 1,   Casp9∅, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 9,   Cyt‑c↑, 2,   Cyt‑c∅, 2,   Fas↓, 2,   Ferroptosis↓, 21,   Ferroptosis↑, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 53,   iNOS↑, 2,   necrosis↓, 1,   p38↓, 5,   p38↑, 1,   p‑p38↓, 3,   Pyro↓, 2,   survivin↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 8,   Akt↑, 29,   Akt↝, 1,   p‑Akt↑, 6,   e-Akt↑, 1,   AMPKα↑, 2,   CREB↑, 3,   p‑CREB↑, 3,   ERK↓, 11,   ERK↑, 10,   p‑ERK↓, 2,   p‑ERK↑, 3,   e-ERK↑, 1,   HCAR2↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB?, 1,   IκB↑, 2,   JAK↓, 2,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 10,   JNK↑, 2,   p‑JNK↓, 6,   p‑JNK↑, 1,   LPAR1/EDG2↑, 1,   MAPK?, 1,   MAPK↓, 29,   MAPK↑, 4,   MAPK↝, 2,   p‑MAPK?, 1,   p‑MAPK↓, 2,   MEK↓, 1,   Mst1↓, 1,   mTOR↓, 8,   mTOR↑, 5,   p‑mTOR↓, 3,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PFKFB2↓, 1,   PI3K↓, 6,   PI3K↑, 24,   p‑PI3K↑, 1,   PKA↑, 2,   PKCδ↓, 2,   PKCδ↑, 3,   PP2A↑, 2,   PTEN↓, 3,   p‑PTEN↑, 1,   PTP1B↓, 1,   RIP1↓, 1,   STAT↓, 4,   STAT3↓, 8,   STAT3↑, 2,   STAT3↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF2↑, 1,   ATF4↓, 4,   ATF4↑, 1,   cJun↓, 3,   p‑cJun↓, 2,   cMyc↓, 1,   p‑cMyc↑, 1,   DNMT1↓, 2,   DNMT3A↓, 2,   DNMTs↓, 1,   FOXO↑, 1,   FOXO3↑, 3,   HDAC?, 1,   HDAC↓, 4,   HDAC↑, 1,   HDAC2↓, 1,   HDAC3↓, 1,   miR-34a↓, 1,   other↓, 5,   other↑, 9,   other↝, 11,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 9,   CHOP/DDIT3↑, 2,   eIF2α↓, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 15,   GRP78/BiP↓, 9,   GRP78/BiP↑, 4,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 7,   HSP70/HSPA5↝, 1,   HSPs↑, 3,   IRE1↓, 1,   NQO2↑, 1,   PERK↓, 1,   p‑PERK↑, 1,   UPR↓, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   ATG5↓, 1,   ATG7↓, 1,   autophagy↓, 1,   autophagy↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 1,   LC3II↓, 1,   LC3II↑, 1,   LC3s↓, 1,   MitoP↓, 1,   MitoP↑, 3,   p62↓, 2,   p62↑, 6,   PARK2↑, 3,   TFEB↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,   DNAdam↓, 12,   DNArepair↑, 1,   P53↓, 4,   PARP↓, 1,   PARP∅, 1,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 1,   PCNA↑, 1,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 2,   cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   GADD45A↑, 1,   Ki-67↓, 3,   Ki-67↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   cFos↓, 1,   CHIP↑, 1,   Choline↑, 1,   Diff↓, 1,   Diff↑, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 2,   Ki-67↓, 3,   Ki-67↑, 1,   mTORC1↓, 1,   Nestin↑, 1,   neuroG↑, 9,   NOTCH1↑, 1,   p300↓, 1,   TumCP↓, 3,   Wnt↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 11,   AP-1↓, 3,   AP-1↑, 1,   mt-ATPase↑, 1,   Ca+2↓, 11,   Ca+2↑, 2,   Ca+2↝, 3,   i-Ca+2↓, 1,   cal2↓, 1,   Cartilage↑, 3,   COL1↓, 2,   COL1↑, 1,   E-cadherin↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   heparanase↑, 1,   LRP1↑, 1,   MMP1↓, 1,   MMP2↓, 4,   MMP2↑, 2,   MMP7↓, 1,   MMP9↓, 8,   MMP9↑, 1,   MMPs↓, 2,   MUC1↑, 1,   Na+↑, 1,   NFAT↓, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   SMAD3↓, 1,   p‑T-cadherin↓, 1,   TG2/TGase↓, 1,   TGF-β↓, 9,   TGF-β↑, 2,   TGF-β1↓, 3,   TGF-β1↑, 2,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 4,   TXNIP↑, 1,   uPA↑, 1,   Vim↓, 1,   α-SMA↓, 4,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 2,   E-sel↓, 3,   ECM/TCF↑, 1,   eNOS↑, 1,   p‑eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 2,   Hif1a↑, 1,   NO↓, 37,   NO↑, 4,   TXA2↓, 1,   VCAM-1↓, 11,   VEGF↓, 5,   VEGF↑, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 43,   BBB↝, 1,   BBB∅, 2,   CLDN1↑, 2,   CLDN5↑, 1,   GastroP↑, 4,   GLUT1↑, 2,   GLUT2↑, 2,   GLUT3↑, 3,   GLUT4↑, 7,   H+/K+-ATPase↓, 1,   IBI↑, 5,   memfluid↑, 1,   MMP↓, 3,   MMP↑, 24,   MUC5AC↓, 1,   Na+↑, 1,   NHE3↑, 1,   OCLN↓, 1,   OCLN↑, 2,   TJ↑, 2,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 1,   TRPV3↑, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 2,   BALF-Infl↓, 1,   CB2 / CNR2↑, 2,   CCL11↓, 1,   CD25+↑, 1,   CD4+↑, 2,   CD40↓, 1,   COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 76,   COX2/PTGS2↑, 2,   CXCc↓, 1,   FOXP3↑, 2,   HCAR2↑, 1,   HMGB1↓, 5,   ICAM-1↓, 9,   IFN-γ↓, 8,   IFN-γ↑, 3,   IgE↓, 1,   IL1↓, 5,   IL10↓, 11,   IL10↑, 14,   IL12↓, 5,   IL12↑, 1,   IL17↓, 8,   IL18↓, 3,   IL1α↓, 1,   IL1β↓, 99,   IL2↓, 6,   IL2↑, 1,   IL22↓, 1,   IL23↓, 3,   IL33↓, 2,   IL4↓, 7,   IL4↑, 3,   IL5↓, 1,   IL6↓, 97,   IL6↑, 4,   IL8↓, 14,   Imm↓, 1,   Imm↑, 4,   Imm↝, 1,   INF-γ↓, 3,   Inflam↓, 248,   Inflam↑, 2,   IP-10/CXCL-10↓, 2,   IRF3↓, 1,   LPS↓, 2,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 11,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 2,   MyD88↓, 3,   NeuroI↓, 8,   NF-kB↓, 146,   NF-kB↑, 3,   NK cell↑, 2,   NLRP3↓, 39,   NLRP3↑, 1,   NOD1↓, 1,   p65↓, 5,   PGE2↓, 23,   PGE2↑, 1,   RAGE↓, 3,   RANTES↓, 2,   Th2↓, 1,   TLR1↓, 1,   TLR2↓, 4,   TLR4↓, 28,   TLR4↑, 1,   TNF-α↓, 139,   TRAF1↓, 1,   TRAF6↓, 1,   Treg lymp↝, 1,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 5,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5-AR↓, 1,   5HT↓, 1,   5HT↑, 6,   Ach↑, 9,   AChE↓, 45,   AChE↑, 1,   ADAM10↑, 2,   BChE↓, 7,   BDNF↓, 1,   BDNF↑, 47,   BDNF⇅, 1,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 8,   ChE↓, 1,   GABA↓, 1,   GABA↑, 3,   GDNF↑, 1,   MAOA↓, 7,   MAOB↓, 2,   NGF↑, 9,   PSD95↑, 6,   RELN↑, 1,   SNAP25↑, 3,   SYP↑, 1,   TPH1↓, 1,   TrkB↑, 5,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 9,   Aβ↓, 54,   Aβ42↓, 6,   BACE/β-secretase↓, 25,   IDE↑, 2,   PSEN1/PS1↓, 1,   tau↓, 12,   p‑tau↓, 20,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AhR↑, 3,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   AR↓, 1,   BNP↓, 1,   cortisol↓, 1,   CYP19↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   FGF21↑, 1,   GLP-1R↑, 1,   GR↑, 2,   GR↝, 1,   NR1H4↑, 1,   PPARα↑, 5,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 18,   p‑PPARγ↓, 1,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv?, 1,   BioAv↓, 44,   BioAv↑, 49,   BioAv↝, 32,   BioEnh↑, 1,   ChemoSen↑, 3,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2C6↑, 1,   CYP2D1↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   CYP3A2↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 39,   eff↓, 8,   eff↑, 40,   eff↝, 3,   GSTA1↓, 1,   GSTA1↑, 2,   GSTP1/GSTπ↓, 1,   GSTP1/GSTπ↑, 1,   Half-Life↓, 6,   Half-Life↑, 4,   Half-Life↝, 18,   Half-Life∅, 1,   MRP↓, 1,   P-gp/ABCB1↓, 1,   P450↑, 2,   selectivity↑, 2,   Synergy↑, 25,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 32,   ALB↑, 1,   ALP↓, 6,   AR↓, 1,   AST↓, 33,   BG↓, 2,   Bil↓, 1,   Bil↑, 2,   BloodF↑, 3,   BMD↑, 4,   BP↓, 8,   BP↝, 2,   BP∅, 1,   p‑BRCA1↑, 1,   BUN?, 1,   BUN↓, 6,   CEA↓, 1,   colonLen↑, 2,   creat↓, 13,   CRP↓, 10,   Ferritin↑, 2,   IL6↓, 97,   IL6↑, 4,   IRes↑, 1,   IRes↝, 1,   LDH↓, 12,   LDH↑, 3,   NOS2↓, 3,   RAGE↓, 3,   SpO2↑, 1,   TC↓, 3,   TG/TAG↓, 3,   TMAO↓, 1,   Urea↓, 3,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 1,   Analgesic↑, 2,   AntiAge↑, 11,   antiAll?, 1,   antiAll↑, 18,   AntiArt↑, 6,   AntiCan↑, 22,   antiCG↑, 2,   AntiDiabetic↑, 16,   AntiMyl↑, 1,   antiPs↑, 2,   AntiTum↑, 8,   ANXi↓, 1,   cardioP?, 2,   cardioP↑, 79,   CardioT↓, 3,   chemoP↑, 19,   chemoPv↑, 3,   cognitive↓, 1,   cognitive↑, 86,   diuretic↑, 2,   fatigue↓, 1,   GFR↑, 1,   hepatoP↓, 3,   hepatoP↑, 73,   Learn↑, 14,   memory↑, 76,   Mood↑, 4,   motorD↓, 1,   motorD↑, 11,   Mucositis↓, 1,   neuroP↓, 1,   neuroP↑, 184,   NP/CIPN↓, 3,   Obesity↓, 17,   OS↑, 9,   Pain↓, 6,   QoL↓, 1,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 36,   Risk↓, 2,   Sleep↑, 2,   Strength↑, 5,   Stress↓, 1,   Stroke↓, 18,   toxicity?, 1,   toxicity↓, 32,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 10,   toxicity∅, 7,   Weight↓, 3,   Weight↑, 2,   Weight∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 12,   AntiFungal↑, 4,   AntiP↑, 2,   AntiViral↑, 11,   Bacteria↓, 19,   Diar↓, 3,   GutMicro↑, 35,   Sepsis↓, 9,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 7,  
Total Targets: 786

Scientific Paper Hit Count for: NRF2, nuclear factor erythroid 2-related factor 2
45 Sulforaphane (mainly Broccoli)
29 Curcumin
23 Luteolin
23 Quercetin
23 Thymoquinone
22 Resveratrol
19 Lycopene
17 EGCG (Epigallocatechin Gallate)
15 Shikonin
14 brusatol
14 Fisetin
13 Chemotherapy
13 Hydrogen Gas
13 Licochalcone A
13 Silymarin (Milk Thistle) silibinin
12 Alpha-Lipoic-Acid
12 Baicalein
11 doxorubicin
11 Ashwagandha(Withaferin A)
10 Cisplatin
10 Apigenin (mainly Parsley)
10 Chrysin
10 isoorientin
9 Silver-NanoParticles
9 Selenite (Sodium)
9 Artemisinin
9 Radiotherapy/Radiation
9 Selenium
8 Vitamin C (Ascorbic Acid)
8 Phenethyl isothiocyanate
8 Boron
8 Chlorogenic acid
8 Propolis -bee glue
8 Isoliquiritigenin
8 Kaempferol
8 Morin
8 Pterostilbene
8 Rosmarinic acid
7 Carnosic acid
7 Hyperoside
7 Piperlongumine
6 Allyl isothiocyanate
6 Allicin (mainly Garlic)
6 Berberine
6 Beta-Caryophyllene
6 Isothiocyanates
6 Honokiol
6 Isovitexin
5 Benzyl isothiocyanate
5 Betulinic acid
5 Boswellia (frankincense)
5 Crocetin
5 isoquercitrin
5 Melatonin
5 Mushroom Lion’s Mane, Hericium erinaceus
4 5-fluorouracil
4 Selenium NanoParticles
4 Vitexin
4 Matrine
4 Urolithin
3 Astaxanthin
3 Berbamine
3 xanthohumol
3 Brucea javanica
3 Capsaicin
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Carvacrol
3 Centella asiatica / Gotu kola → asiaticoside
3 Cichoric acid / Chicoric acid
3 Cynaropicrin
3 Diindolylmethane
3 Disulfiram
3 Copper and Cu NanoParticles
3 Emodin
3 Ferulic acid
3 Gallic acid
3 Ginger/6-Shogaol/Gingerol
3 Ginkgetin
3 Linalool
3 Lutein
3 Magnetic Fields
3 Parthenolide
2 1,8-Cineole
2 Auranofin
2 Lapatinib
2 Thymol-Thymus vulgaris
2 methotrexate
2 Cinnamon
2 Carvone
2 Cucurbitacin
2 Chlorella (Chlorella vulgaris)
2 Cysteamine
2 Eugenol
2 Ginkgo biloba
2 Ginseng
2 Hydroxycinnamic-acid
2 HydroxyTyrosol
2 Isorhamnetin
2 Licorice
2 Magnolol
2 methylseleninic acid
2 Metformin
2 Moringa oleifera
2 Methylsulfonylmethane
2 Nimbolide
2 salinomycin
2 Taurine
1 Andrographis
1 Docetaxel
1 Baicalin
1 Biochanin A
1 Cannabidiol
1 buckwheat sprouts
1 Butyrate
1 Caffeic acid
1 Catechins
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Camu camu
1 Celastrol
1 chaetocin
1 chitosan
1 Calorie Restriction Mimetics
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Ursolic acid
1 Spirulina(Arthrospira/Limnospira)
1 diet FMD Fasting Mimicking Diet
1 diet Methionine-Restricted Diet
1 Indole-3-carbinol
1 D-limonene
1 Dandelion Root
1 Ellagic acid
1 Formononetin
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Geraniol
1 Gossypol/AT-101
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Isobavachalcone
1 iodine
1 Juglone
1 lambertianic acid
1 Modified Citrus Pectin
1 Methyl salicylate / Sweet Birch oil
1 Aspirin
1 Moringin
1 Mangiferin
1 Lemon Balm/Melissa officinalis
1 Zeolite
1 Myricetin
1 Oleuropein
1 Purple Corn / Purple Maize
1 Propyl gallate
1 Phenolic Acids
1 Piperine
1 Plumbagin
1 Polyphenols
1 Sulfasalazine
1 Oxygen, Hyperbaric
1 irinotecan
1 acetazolamide
1 Salvia miltiorrhiza
1 Spermidine
1 erastin
1 Terminalia bellirica
1 Terpenoids
1 triptolide
1 Vanillic Acid
1 Mung Bean Sprouts
1 Vitamin B1/Thiamine
1 Vitamin D3
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:226  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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