PARP Cancer Research Results

PARP, poly ADP-ribose polymerase (PARP) cleavage: Click to Expand ⟱
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Type:
Poly (ADP-ribose) polymerase (PARP) cleavage is a hallmark of caspase activation. PARP (Poly (ADP-ribose) polymerase) is a family of proteins involved in a variety of cellular processes, including DNA repair, genomic stability, and programmed cell death. PARP enzymes play a crucial role in repairing single-strand breaks in DNA.
PARP has gained significant attention, particularly in the treatment of certain types of tumors, such as those with BRCA1 or BRCA2 mutations. These mutations impair the cell's ability to repair double-strand breaks in DNA through homologous recombination. Cancer cells with these mutations can become reliant on PARP for survival, making them particularly sensitive to PARP inhibitors.
PARP inhibitors, such as olaparib, rucaparib, and niraparib, have been developed as targeted therapies for cancers associated with BRCA mutations.

PARP Family:
The poly (ADP-ribose) polymerases (PARPs) are a family of enzymes involved in a number of cellular processes, including DNA repair, genomic stability, and programmed cell death.
PARP1 is the predominant family member responsible for detecting DNA strand breaks and initiating repair processes, especially through base excision repair (BER).

PARP1 Overexpression:
In several cancer types—including breast, ovarian, prostate, and lung cancers—elevated PARP1 expression and/or activity has been reported.
High PARP1 expression in certain cancers has been associated with aggressive tumor behavior and resistance to therapies (especially those that induce DNA damage).
Increased PARP1 activity may correlate with poorer overall survival in tumors that rely on DNA repair for survival.
Scientific Papers found: Click to Expand⟱
8859- MOR,    Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1
- in-vitro, Melanoma, U266 - in-vitro, BC, MCF7 - in-vitro, SCC, SCC4 - in-vitro, BC, MCF-10AT
STAT3↓, Src↓, JAK1↓, JAK2↓, PIAS-3↑, ChemoSen↑, SHP1↑, XIAP↓, cFLIP↓, Mcl-1↓, survivin↓, Bcl-2↓, Bcl-xL↓, IAP2/BIRC3↓, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, selectivity↑,
8780- MSM,    Methylsulfonylmethane Induces Cell Cycle Arrest and Apoptosis, and Suppresses the Stemness Potential of HT-29 Cells
- in-vitro, CRC, HT-29
Apoptosis↑, TumCCA↑, CSCs↓, Dose↝, cl‑PARP↑, cl‑Casp9↑, MMP↓, SOX2↓, OCT4↓, Nanog↓,
8775- MSM,    Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer Cells
- Review, Colon, HCT116
*AntiArt↑, *ROS↓, tumCV↓, Apoptosis↑, PARP↑, Casp3↑, p‑JNK↑, eff↝, *toxicity↓, ChemoSen↑, TumCP↓,
8766- MSM,    Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis
- vitro+vivo, Liver, HepG2 - in-vitro, Liver, HUH7
TumCG↓, Apoptosis↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, TumVol↓, AST↓, ALAT↓,
8804- MT/VAE,    Activation of caspase cascades in Korean mistletoe (Viscum album var. coloratum) lectin-II-induced apoptosis of human myeloleukemic U937 cells
- in-vitro, lymphoma, U937
DNAdam↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, cl‑PKCδ↑, Apoptosis↑,
8936- MushCha,    Inonotus obliquus polysaccharides induces apoptosis of lung cancer cells and alters energy metabolism via the LKB1/AMPK axis
- vitro+vivo, Lung, LLC1
AMPK↑, tumCV↓, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, MMP↓, OXPHOS↓, Glycolysis↓, Dose?, MPT↑, ATP↓,
1128- Myr,    Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer
- vitro+vivo, Ovarian, NA
MAPK↓, ERK↓, PI3K↓, Akt↓, p‑PARP↑, cl‑Casp3↑, Bax:Bcl2↑, TumCMig↓, SMAD3↓,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2/PTGS2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
6489- Nimb,    Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model
- in-vivo, Pca, DU145 - in-vivo, Pca, LNCaP
tumCV↓, Apoptosis↑, TumCI↓, TumCMig↓, STAT3↓, ROS↑, TumCG↓, TumMeta↓, TumCCA↑, DNAdam↑, Casp3↑, Casp7↑, cl‑PARP↑, p‑STAT3↓, IL6↓, GSR↓,
4976- Nimb,    Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition
- vitro+vivo, PC, NA
ROS↑, Apoptosis↑, TumAuto↑, TumCP↓, TumCMig↓, TumCI↓, EMT↓, Dose↓, selectivity↑, Akt↓, eff↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓,
4977- Nimb,    Nimbolide Inhibits SOD2 to Control Pancreatic Ductal Adenocarcinoma Growth and Metastasis
- vitro+vivo, PC, AsPC-1 - in-vitro, PC, PANC1
SOD2↑, TumCG↓, TumMeta↓, ROS↑, Apoptosis↑, PI3K↓, Akt↓, EMT↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, Bcl-2↓,
150- NRF,  CUR,  docx,    Subverting ER-Stress towards Apoptosis by Nelfinavir and Curcumin Coexposure Augments Docetaxel Efficacy in Castration Resistant Prostate Cancer Cells
- in-vitro, Pca, C4-2B
p‑Akt↓, p‑eIF2α↑, ER Stress↑, ATF4↑, CHOP/DDIT3↑, TRIB3↑, ChemoSen↑, Casp3↑, cl‑PARP↑, BID↑, XBP-1↑,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP/DDIT3↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27/CDKN1B↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
8427- OM,    Mitotic arrest and apoptosis in breast cancer cells induced by Origanum majorana extract: upregulation of TNF-α and downregulation of survivin and mutant p53
- in-vitro, BC, MDA-MB-231
tumCV↓, Dose↝, mitA↑, Apoptosis↑, TNF-α↑, Casp3↑, Casp8↑, cl‑PARP↑, survivin↓, p53 Wildtype↓, P21↑, ac‑H3↑, ac‑H4↑, γH2AX↑, DNAdam↑, TumCCA↑,
2070- PB,    Phenylbutyrate-induced apoptosis is associated with inactivation of NF-kappaB IN HT-29 colon cancer cells
- in-vitro, CRC, HT-29
TumCG↓, Apoptosis↑, MMP↓, Casp3↑, PARP↓, NF-kB↓, eff↑,
2057- PB,    Trichomonas vaginalis induces apoptosis via ROS and ER stress response through ER–mitochondria crosstalk in SiHa cells
- in-vitro, Cerv, SiHa
ROS↓, tumCV∅, cl‑PARP↓, cl‑Casp3↓, MMP∅, ER Stress↓,
1674- PBG,  SDT,  HPT,    Study on the effect of a triple cancer treatment of propolis, thermal cycling-hyperthermia, and low-intensity ultrasound on PANC-1 cells
- in-vitro, PC, PANC1 - in-vitro, Nor, H6c7
tumCV↓, ROS↑, eff↑, Dose∅, selectivity↑, MMP↓, mtDam↑, cl‑PARP↑, p‑ERK↓, p‑JNK↑, p‑p38↑, eff↓, ChemoSen↑,
1676- PBG,    Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
- Review, Var, NA
ROS↑, MMP↓, Bcl-2↓, Synergy↑, tumCV↓, TumCCA↑, angioG↓, PAK1↓, HDAC1↓, HDAC2↓, P53↑, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21?, BAX↑, cl‑Casp3↑, cl‑PARP↑, ChemoSen↑,
1682- PBG,    Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits
- Review, Var, NA
i-LDH↓, Akt↓, MAPK↓, NF-kB↓, IL1β↓, IL6↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, ROS↓, Bcl-2↓, PARP↓, P53↑, BAX↑, Casp3↑, TumCCA↑, Cyt‑c↑, MMP↓, eff↑,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27/CDKN1B↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
4957- PEITC,    Phenethyl Isothiocyanate (PEITC) from Cruciferous Vegetables Targets Human Cancer Stem-Like Cells
- vitro+vivo, Cerv, HeLa
CSCs↓, ALDH↓, CD44↓, CD24↓, cl‑PARP↑, DR4↑, DR5↑,
4960- PEITC,    Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells
- in-vivo, Cerv, HeLa
CD44↓, CD24↓, CSCs↓, cl‑PARP↑, DR4↑, DR5↑, TumCP↓,
4929- PEITC,  PacT,    Phenethyl isothiocyanate and paclitaxel synergistically enhanced apoptosis and alpha-tubulin hyperacetylation in breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
ChemoSen↑, Apoptosis↑, TumCCA↑, Synergy↑, CDK1↓, Bcl-2↓, BAX↑, cl‑PARP↑, SAL↑,
5184- PEITC,    Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways
- vitro+vivo, AML, U937
Casp3↑, Casp9↑, Casp8↑, cl‑PARP↑, Apoptosis↑, Mcl-1↓, Akt↓, JNK↑, eff↑,
5218- PG,    Propyl gallate inhibits hepatocellular carcinoma cell growth through the induction of ROS and the activation of autophagy
- in-vitro, HCC, Hep3B
TumCP↓, Apoptosis↑, ROS↑, TumAuto↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, BAD↑, Bcl-2↓, toxicity↓, hepatoP↑, GSH↓,
5219- PG,    Propyl gallate inhibits the growth of HeLa cells via caspase-dependent apoptosis as well as a G1 phase arrest of the cell cycle
- in-vitro, Cerv, HeLa
TumCG↓, TumCCA↑, p27/CDKN1B↑, Apoptosis↑, MMP↓, Casp3↑, Casp8↑, cl‑PARP↑,
1768- PG,    Propyl gallate reduces the growth of lung cancer cells through caspase‑dependent apoptosis and G1 phase arrest of the cell cycle
- in-vitro, Lung, Calu-6 - in-vitro, Lung, A549
TumCG↓, TumCCA↑, Dose∅, Bcl-2↓, cl‑PARP↑, MMP↓, Casp3↑, Casp8↑,
5208- PI,    Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway
- in-vitro, GC, SNU16 - in-vitro, Nor, GES-1
TumCP↓, Apoptosis↑, BAX↑, BAD↑, Cyt‑c↑, cl‑PARP↑, cl‑Casp3↑, Bcl-2↓, Bcl-xL↓, p‑PI3K↓, p‑Akt↓, Ki-67↓, toxicity↓, RadioS↑,
5216- PI,  doxoR,    Piperine enhances doxorubicin sensitivity in triple-negative breast cancer by targeting the PI3K/Akt/mTOR pathway and cancer stem cells
- vitro+vivo, BC, MDA-MB-231
ChemoSen↑, necrosis↑, PTEN↓, PI3K↓, p‑Akt↓, mTOR↓, ALDH↓, TumVol↓, OS↑, cardioP↑, cl‑PARP↑,
2944- PL,    Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells
- in-vitro, Thyroid, IHH4 - in-vitro, Thyroid, 8505C - in-vivo, NA, NA
ROS↑, selectivity↑, tumCV↓, TumCCA↑, Apoptosis↑, ERK↑, Akt↓, mTOR↓, neuroP↑, Bcl-2↓, Casp3↑, PARP↑, JNK↑, *toxicity↓, eff↓, TumW↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2956- PL,    Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis
- in-vitro, PC, NA
ROS↑, Ferroptosis↓, GSH↓, GPx↓, cl‑PARP∅, cl‑Casp3∅, eff↑, eff↑,
2955- PL,    Heme Oxygenase-1 Determines the Differential Response of Breast Cancer and Normal Cells to Piperlongumine
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
ROS?, *ROS∅, other⇅, HO-1↑, *HO-1↑, NRF2↑, Keap1↓, cl‑PARP↑, selectivity↑, GSH↓, GSSG↑,
1947- PL,    Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer
- in-vitro, GC, SGC-7901 - in-vitro, GC, NA
TrxR1↓, ROS↑, ER Stress↑, mtDam↑, selectivity↑, NO↑, TumCCA↑, mt-ROS↑, Casp9↑, Bcl-2↓, Bcl-xL↓, cl‑PARP↑, eff↓, lipid-P↑,
1941- PL,    Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer
- in-vitro, HNSCC, NA
selectivity↑, Synergy↑, ROS↑, toxicity↑, GSH↓, GSSG↑, *GSSG∅, cl‑PARP↑, PUMA↑, GSTP1/GSTπ↓, ChemoSen↑,
5160- PLB,  VitK3,    Plumbagin, Vitamin K3 Analogue, Suppresses STAT3 Activation Pathway through Induction of Protein Tyrosine Phosphatase, SHP-1: Potential Role in Chemosensitization
- in-vitro, Melanoma, U266
STAT3↓, cSrc↓, JAK1↓, JAK2↓, SHP1↑, cycD1/CCND1↓, Bcl-xL↓, VEGF↓, Casp3↑, cl‑PARP↑, TumCCA↑, ChemoSen↑,
3350- QC,    Quercetin and the mitochondria: A mechanistic view
- Review, Var, NA
*antiOx↑, *Inflam↓, *NRF2↑, ROS⇅, *NRF2↑, *HO-1↑, *PPARα↑, *PGC-1α↑, *SIRT1↑, *ATP↑, ATP↓, ERK↓, cl‑PARP↑, Casp9↑, Casp8↑, BAX↑, MMP↓, Cyt‑c↑, Casp3↑, HSP27↓, HSP72↓, RAS↓, Raf↓,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1/ATG6↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
3371- QC,    Quercetin induces MGMT+ glioblastoma cells apoptosis via dual inhibition of Wnt3a/β-Catenin and Akt/NF-κB signaling pathways
- in-vitro, GBM, T98G
TIMP2↑, TumCG↓, TumCMig↓, Apoptosis↑, TumCCA↑, MMP↓, ROS↑, Bax:Bcl2↑, cl‑Casp9↑, cl‑Casp3↑, DNAdam↑, γH2AX↑, MGMT↓, cl‑PARP↑,
66- QC,    Emerging impact of quercetin in the treatment of prostate cancer
- Review, Pca, NA
CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt/(β-catenin)↓, PSA↓, VEGF↓, PARP↑, Casp3↑, Casp9↑, DR5↑, ROS⇅, Shh↓, P53↑, P21↑, EGFR↓, TumCCA↑, ROS↑, miR-21↓, TumCP↓, selectivity↑, PDGF↓, EGF↓, TNF-α↓, VEGFR2/KDR/Flk1↓, mTOR↓, cMyc↓, MMPs↓, GRP78/BiP↑, CHOP/DDIT3↑,
71- QC,    Role of Bax in quercetin-induced apoptosis in human prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PrEC - in-vitro, Pca, YPEN-1 - in-vitro, Pca, HCT116
Casp8↑, Casp9↑, PARP↑, BAD↓, BAX↑, PI3K/Akt↓, Cyt‑c↑, selectivity↑,
41- QC,    Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft
- vitro+vivo, AML, HL-60
Casp8↑, Casp9↑, Casp3↑, ROS↑, ERK↑, cl‑PARP↑, MMP↓, eff↓,
90- QC,  HYP,    Combination of quercetin and hyperoside inhibits prostate cancer cell growth and metastasis via regulation of microRNA‑21
- in-vitro, Pca, PC3
ROS↑, cl‑Casp3↑, cl‑PARP↑, miR-21↓, PDCD4↑, TAC↑, tumCV↓, TumCI↓,
86- QC,  PacT,    Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3)
- vitro+vivo, Pca, PC3
BAD↑, IGFBP3↑, Cyt‑c↑, cl‑Casp9↑, Casp10↑, cl‑PARP↑, Casp3↑, IGF-1R↓, PI3K↓, p‑Akt↓, cycD1/CCND1↓, IGF-1↓, IGF-2↓, IGF-1R↓, MMP↓, Apoptosis↑, NA?,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
2439- RES,    By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice
- in-vitro, HCC, HCCLM3 - in-vitro, Nor, L02 - in-vitro, HCC, SMMC-7721 cell - in-vitro, HCC, Bel-7402 - in-vitro, HCC, HUH7
HK2↓, ChemoSen↑, other↑, Glycolysis↓, lactateProd↓, TumCP↓, Casp3↑, cl‑PARP↑, PKM2↓,
3097- RES,    Resveratrol Induces Notch2-mediated Apoptosis and Suppression of Neuroendocrine Markers in Medullary Thyroid Cancer
- in-vitro, Thyroid, TT
TumCG↓, cl‑Casp3↑, p‑PARP↑, NOTCH2↑,
2981- RES,    Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways
- in-vitro, Colon, HT-29 - in-vitro, Colon, SW48
TumCCA↑, p27/CDKN1B↑, cycD1/CCND1↓, TumCP↓, IGF-1R↓, Akt↓, Wnt↓, P53↑, Apoptosis↑, Sp1/3/4↓, cl‑PARP↑, β-catenin/ZEB1↓, MDM2↓,
104- RES,  QC,    Resveratrol and Quercetin in Combination Have Anticancer Activity in Colon Cancer Cells and Repress Oncogenic microRNA-27a
- in-vitro, Colon, HT-29
Casp3↑, PARP↑, survivin↓, miR-27a-3p↓, Sp1/3/4↓, ZBTB10↑, ROS⇅, TAC↑, tumCV↓,

Showing Research Papers: 351 to 400 of 460
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 460

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 2,   NA↑, 2,   NA⇅, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 2,   ARE/EpRE↑, 1,   Catalase↓, 5,   Catalase↑, 2,   Copper↑, 1,   ENOX2↓, 1,   Fenton↑, 3,   GPx↓, 3,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 3,   GSH↓, 30,   GSH↑, 5,   i-GSH∅, 1,   GSH/GSSG↓, 2,   GSR↓, 2,   GSR↑, 2,   GSSG↑, 2,   GSTs↓, 2,   GSTs↑, 2,   H2O2↑, 5,   i-H2O2↑, 1,   HO-1↓, 10,   HO-1↑, 11,   HO-2↓, 1,   Iron↑, 2,   i-Iron↑, 1,   Keap1↓, 2,   lipid-P?, 1,   lipid-P↓, 1,   lipid-P↑, 10,   MDA↓, 2,   MDA↑, 4,   MPO↓, 1,   NOX4↑, 1,   NQO1↓, 3,   NQO1↑, 1,   NRF2↓, 18,   NRF2↑, 18,   p‑NRF2↑, 1,   Prx↓, 1,   Prx4↑, 1,   PrxII↓, 1,   RNS↑, 2,   ROS?, 3,   ROS↓, 20,   ROS↑, 231,   ROS⇅, 10,   ROS↝, 1,   ROS∅, 2,   i-ROS↑, 2,   mt-ROS↑, 7,   SOD↓, 6,   SOD↑, 4,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 1,   TAC↑, 2,   Thiols↓, 1,   Trx↓, 2,   ox-Trx1↑, 1,   TrxR↓, 7,   TrxR1↓, 6,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 7,   CDC25↓, 15,   EGF↓, 4,   ETC↓, 3,   MFN2↑, 1,   mitResp↓, 2,   MKK7↓, 1,   mtDam↑, 20,   OCR↓, 3,   OCR↑, 1,   OXPHOS↓, 5,   mt-OXPHOS↓, 2,   PDH↓, 2,   PDH↝, 1,   p‑PDH↑, 1,   PINK1↑, 3,   SDH↓, 1,   SIRT3↓, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ACC↑, 3,   p‑ACC↑, 2,   ALAT↓, 4,   ALDOA↓, 2,   AMP↑, 1,   AMPK↓, 2,   AMPK↑, 22,   p‑AMPK↑, 2,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 15,   ATP↑, 1,   citrate↓, 1,   CPT1A↓, 1,   ECAR↝, 1,   ENO1↓, 3,   FASN↓, 4,   FASN↑, 1,   FBPase↑, 1,   GAPDH↓, 2,   glucoNG↓, 1,   glucoNG↑, 1,   glucose↓, 2,   GlucoseCon↓, 8,   GlutMet↓, 1,   Glycolysis↓, 23,   GSK‐3β↓, 9,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 8,   H2S↑, 1,   HK1↓, 1,   HK2↓, 13,   HMG-CoA↓, 1,   lactateProd↓, 12,   LDHA↓, 6,   LDL↓, 2,   lipidLev↓, 1,   MCT4↓, 1,   NAD↓, 2,   NADPH↓, 1,   NADPH↑, 2,   O-Glc↓, 1,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 8,   PDKs↓, 1,   PFK↓, 3,   PFK2?, 1,   PGK1↓, 1,   PKM2↓, 13,   PKM2∅, 1,   PLA2↓, 1,   PPP↓, 1,   SIRT1↓, 9,   SIRT1↑, 2,   TCA↓, 3,   TS↓, 1,   Warburg↓, 5,   β-oxidation↓, 2,  

Cell Death(tgid=5) ⓘ

14-3-3 proteins↓, 1,   AIF↑, 13,   APAF1↑, 11,   Apoptosis↓, 9,   Apoptosis↑, 253,   mt-Apoptosis↑, 2,   ASC↓, 1,   BAD↓, 3,   BAD↑, 21,   p‑BAD↓, 2,   Bak↓, 1,   Bak↑, 14,   BAX↓, 4,   BAX↑, 146,   BAX↝, 1,   BAX∅, 1,   Bax:Bcl2↑, 44,   Bcl-2↓, 167,   Bcl-2↑, 6,   Bcl-2↝, 1,   Bcl-2∅, 2,   cl‑Bcl-2↓, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 53,   Bcl-xL↑, 1,   Bcl-xL∅, 1,   BID↑, 11,   cl‑BID↑, 2,   BIM↑, 10,   Casp↑, 38,   Casp↝, 2,   cl‑Casp↑, 2,   Casp1↓, 1,   Casp1↑, 2,   Casp10↑, 3,   Casp12?, 1,   Casp12↑, 3,   Casp2↑, 1,   Casp3?, 1,   Casp3↓, 3,   Casp3↑, 215,   Casp3↝, 1,   Casp3∅, 1,   cl‑Casp3↓, 1,   cl‑Casp3↑, 94,   cl‑Casp3⇅, 1,   cl‑Casp3∅, 1,   proCasp3↓, 4,   proCasp3↑, 5,   Casp6↓, 1,   Casp6↑, 3,   Casp7↑, 29,   cl‑Casp7↑, 11,   Casp8↓, 2,   Casp8↑, 60,   Casp8∅, 2,   cl‑Casp8↑, 24,   proCasp8↓, 1,   proCasp8↑, 4,   Casp9?, 1,   Casp9↓, 2,   Casp9↑, 127,   Casp9∅, 1,   cl‑Casp9↓, 1,   cl‑Casp9↑, 38,   proCasp9↓, 1,   proCasp9↑, 4,   cFLIP↓, 8,   Cyt‑c↓, 3,   Cyt‑c↑, 126,   Cyt‑c↝, 2,   Cyt‑c?, 1,   Diablo↑, 12,   DR5↑, 30,   Endon↑, 1,   FADD↑, 9,   Fas↓, 1,   Fas↑, 21,   FasL↑, 10,   Ferroptosis↓, 1,   Ferroptosis↑, 5,   GRP58↓, 1,   GSDME↑, 1,   cl‑GSDME↑, 1,   HEY1↓, 2,   IAP1↓, 11,   IAP2/BIRC3↓, 5,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 2,   ICD↑, 1,   iNOS↓, 12,   Mcl-1?, 1,   Mcl-1↓, 35,   Mcl-1↑, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 11,   MDM2↑, 1,   p‑MDM2↓, 2,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 1,   Necroptosis↑, 4,   necrosis↑, 7,   NOXA↑, 5,   p38↓, 2,   p38↑, 18,   p‑p38↓, 4,   p‑p38↑, 10,   PDCD4↑, 1,   PUMA↑, 10,   Pyro↑, 4,   RIP1↓, 2,   RIP3↓, 1,   RIP3↑, 2,   p‑RIP3↑, 2,   survivin↓, 73,   TNFR 1↑, 2,   TRAIL↑, 3,   TRAILR↑, 2,   TumCD↓, 1,   TumCD↑, 23,   XIAP?, 1,   XIAP↓, 35,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 118,   Akt↑, 4,   p‑Akt↓, 49,   AKT1↓, 1,   BRAF↓, 2,   CaMKII ↓, 2,   CIP2A↓, 1,   CK2↓, 4,   cMET↓, 1,   p‑cMET↑, 1,   p‑CREB↓, 1,   cSrc↓, 6,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 29,   EGFR↑, 2,   p‑EGFR↓, 1,   ERK↓, 36,   ERK↑, 12,   p‑ERK↓, 21,   p‑ERK↑, 5,   FGFR1↓, 3,   FGFR2↓, 1,   HER2/EBBR2↓, 14,   HGF/c-Met↓, 3,   IGF-1R↓, 4,   IGF-1R↑, 1,   IGFR↓, 2,   IKKα↓, 7,   IKKα↑, 1,   ILK↓, 1,   IκB↓, 3,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 2,   JAK1?, 1,   JAK1↓, 8,   JAK1↑, 1,   p‑JAK1↓, 2,   JAK2↓, 10,   p‑JAK2↓, 5,   JNK↓, 2,   JNK↑, 23,   p‑JNK↓, 2,   p‑JNK↑, 10,   cl‑JNK↑, 1,   MAPK↓, 29,   MAPK↑, 10,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MEK↓, 4,   p‑MEK↓, 1,   p‑MEK↑, 1,   MKK4↓, 1,   mTOR↓, 56,   mTOR↑, 4,   mTOR↝, 1,   p‑mTOR↓, 13,   mTORC2↓, 4,   p70S6↓, 2,   p70S6↑, 1,   P70S6K↓, 3,   p‑P70S6K↓, 2,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 84,   PI3K↑, 1,   p‑PI3K↓, 8,   PI3K/Akt↓, 3,   PI3k/Akt/mTOR↓, 1,   PIAS-3↑, 1,   PKA↓, 1,   PKCδ↓, 8,   cl‑PKCδ↑, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 2,   PTEN↑, 21,   p‑PTEN↓, 1,   Raf↓, 4,   c-Raf↓, 1,   RAS↓, 11,   RSK2/RPS6KA3/p90RSK2↓, 1,   RTK-RAS↓, 1,   SHP1↑, 4,   Sp1/3/4↓, 7,   Src↓, 3,   p‑Src↓, 1,   STAT↓, 2,   p‑STAT↓, 1,   STAT3↓, 58,   STAT3↑, 2,   p‑STAT3↓, 18,   p‑STAT3↑, 1,   STAT5↓, 2,   STAT6↓, 2,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 2,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF1↓, 1,   ATF2↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 15,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 6,   cJun↑, 4,   cMyc↓, 35,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 7,   DNMT3A↓, 2,   DNMTs↓, 3,   EZH2↓, 2,   FOXM1↓, 3,   FOXO1↑, 2,   FOXO3↓, 3,   FOXO3↑, 4,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↑, 2,   H3↓, 4,   H3↑, 2,   p‑H3↓, 2,   ac‑H3↑, 1,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 4,   HATs↑, 1,   HDAC↓, 16,   HDAC1↓, 4,   HDAC2↓, 4,   HDAC3↓, 3,   HDAC8↓, 1,   HES1↓, 2,   miR-134↑, 1,   miR-139-5p↑, 1,   miR-200b↑, 1,   miR-205↑, 1,   miR-21↓, 5,   miR-21↑, 1,   miR-21↝, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-29b↓, 1,   miR-339-5p↝, 1,   miR-340↑, 1,   miR-34a↑, 1,   miR-34b-5p↑, 1,   miR-384↑, 1,   Myc↓, 4,   MYCN↓, 1,   OCT4↓, 6,   other↓, 1,   other↑, 1,   other⇅, 1,   other↝, 7,   PhotoS↑, 1,   SOX2↓, 3,   SOX4↓, 1,   SOX4↑, 1,   SOX9↓, 1,   SUV39H↓, 2,   TCF-4↓, 1,   TFAP2A↓, 1,   tumCV↓, 76,   tumCV∅, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   CHOP/DDIT3↑, 36,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 6,   p‑eIF2α↑, 9,   ER Stress↓, 1,   ER Stress↑, 53,   GRP78/BiP↓, 1,   GRP78/BiP↑, 18,   HSF1↓, 1,   HSP27↓, 5,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 9,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP72↓, 1,   HSP90↓, 11,   HSPs↓, 1,   IRE1↑, 6,   PDI↑, 1,   PERK↑, 9,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↑, 11,   XBP-1↓, 2,   XBP-1↑, 4,   XBP-1↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↓, 1,   ATG3↑, 4,   ATG5↑, 12,   ATG7↑, 3,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 20,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 6,   LC3A↑, 1,   LC3B↑, 2,   LC3B-II↑, 5,   LC3I↓, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 14,   LC3s↑, 1,   lysoMP↑, 1,   MitoP↑, 1,   p62↓, 10,   p62↑, 5,   PARK2↑, 3,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto↑, 44,   TumAuto⇅, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   ATM↑, 1,   p‑ATM↑, 1,   BRCA1↓, 1,   BRCA2↓, 1,   DFF45↓, 2,   DFF45↑, 3,   DNA-PK↑, 1,   DNAdam↓, 4,   DNAdam↑, 71,   DNArepair↓, 4,   ERCC1↓, 1,   ERCC4/XPF↓, 1,   hTERT/TERT↓, 7,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   p16↑, 1,   P53?, 1,   P53↓, 6,   P53↑, 81,   p‑P53↓, 1,   p‑P53↑, 7,   ac‑P53↑, 1,   p53 Wildtype↓, 1,   PARP↓, 22,   PARP↑, 85,   PARP↝, 4,   PARP∅, 1,   p‑PARP↑, 6,   cl‑PARP↓, 6,   cl‑PARP↑, 324,   cl‑PARP↝, 1,   cl‑PARP∅, 2,   proPARP↓, 1,   PCNA↓, 21,   SIRT6↑, 1,   Telomerase↓, 13,   TOP1↓, 4,   TOP2↓, 3,   TOP2↑, 1,   TP53↓, 1,   TP53↑, 1,   TRF2↓, 1,   γH2AX↓, 1,   γH2AX↑, 12,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 20,   CDK1↑, 1,   p‑CDK1↓, 2,   p‑CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 38,   CDK2↑, 3,   p‑CDK2↓, 2,   CDK4↓, 42,   CDK4↑, 1,   CDK4/6↓, 1,   CDK6↓, 21,   CDK6↑, 2,   CDK8↓, 1,   CHK1↓, 2,   CHK1↑, 1,   Chk2↓, 3,   Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 14,   CycB/CCNB1↓, 31,   CycB/CCNB1↑, 6,   cycD1/CCND1↓, 82,   cycD1/CCND1↑, 1,   cycD1/CCND1↝, 1,   CycD3↓, 4,   CycD3↑, 1,   cycE/CCNE↓, 26,   cycE/CCNE↑, 1,   E2Fs↓, 2,   GADD45A↓, 1,   GADD45A↑, 1,   Ki-67↓, 21,   MAD↓, 1,   mitA↑, 3,   p19↑, 1,   P21?, 2,   P21↓, 6,   P21↑, 61,   P21↝, 1,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 28,   pRB↑, 1,   p‑pRB↓, 2,   p‑RB1↓, 7,   cl‑RB1↓, 1,   Securin↓, 1,   TubPol↓, 1,   TumCCA?, 1,   TumCCA↓, 7,   TumCCA↑, 188,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   ALDH↓, 4,   Axin2↑, 1,   BMI1↓, 1,   CD133↓, 2,   CD24↓, 2,   CD34↓, 1,   cFos↓, 6,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 21,   Diff↓, 1,   Diff↑, 1,   FGF↓, 5,   Gli↓, 1,   Gli1↓, 5,   HH↓, 6,   HMGCR↓, 1,   IGF-1↓, 8,   IGF-2↓, 1,   IGFBP1↑, 1,   IGFBP3↑, 3,   JAG1↓, 1,   Ki-67↓, 21,   Let-7↑, 1,   mTORC1↓, 4,   Nanog↓, 3,   Nestin↓, 1,   NICD↓, 1,   NOTCH↓, 10,   NOTCH↑, 1,   NOTCH1↓, 10,   NOTCH1↑, 1,   NOTCH2↑, 1,   NOTCH3↓, 3,   OGFr↑, 1,   p300↓, 1,   PTCH2↓, 1,   SAL↑, 1,   SCF↓, 2,   Shh↓, 7,   Smo↓, 2,   STAT1↓, 1,   Sufu↑, 1,   TAZ↓, 1,   TumCG?, 1,   TumCG↓, 72,   TumCG↑, 3,   TumCP↓, 131,   TumCP↑, 6,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt↓, 23,   Wnt↑, 1,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 5,   AP-1↝, 1,   AXL↓, 3,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 27,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 2,   cal2↓, 1,   cal2↑, 1,   Cav1↓, 1,   Cdc42↓, 2,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 6,   E-cadherin↑, 28,   EM↑, 1,   EMT↓, 39,   EMT↑, 1,   EMT↝, 1,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 8,   p‑FAK↓, 3,   Fibronectin↓, 3,   GLI2↓, 3,   IQGAP3↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   ITGB4↓, 1,   KRAS↓, 2,   LAMs↓, 1,   LEF1↓, 1,   MET↓, 3,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 7,   MMP13↓, 1,   MMP16↓, 1,   MMP2↓, 60,   MMP3↓, 7,   MMP7↓, 6,   MMP9↓, 67,   MMPs↓, 24,   MMPs↝, 1,   MUC4↓, 1,   N-cadherin↓, 21,   p44↓, 1,   PAK1↓, 2,   pax↓, 1,   p‑pax↓, 1,   PDGF↓, 5,   Rac1↓, 4,   RECK↑, 1,   Rho↓, 4,   ROCK1↓, 2,   Slug↓, 8,   Smad1↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 3,   SMAD3↑, 1,   p‑SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 22,   TET1↓, 1,   TET1↑, 2,   TGF-β↓, 10,   TGF-β↑, 1,   TIMP1↑, 10,   TIMP2↑, 10,   TIMP3↑, 1,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 2,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 53,   TumCMig↓, 49,   TumMeta?, 1,   TumMeta↓, 42,   TumMeta↑, 2,   Twist↓, 14,   Tyro3↓, 1,   uPA↓, 14,   uPAR↓, 1,   Vim↓, 22,   Vim↑, 1,   Zeb1↓, 7,   Zeb1↑, 1,   ZEB2↓, 2,   α-tubulin↓, 2,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 32,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 70,   angioG↑, 1,   CD31/PECAM-1↓, 2,   ECM/TCF↓, 1,   Endoglin↑, 3,   eNOS↓, 2,   HIF-1↓, 3,   Hif1a↓, 40,   NO↓, 1,   NO↑, 4,   VCAM-1↓, 2,   VEGF↓, 79,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 16,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   BBB∅, 1,   CLDN1↓, 2,   CLDN1↑, 1,   CLDN2↓, 1,   EPR↑, 1,   GLUT1↓, 9,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 135,   MMP↑, 2,   MMP∅, 1,   MPT↑, 8,   NHE1↓, 1,   OCLN↑, 1,   SVCT-2↓, 1,   SVCT-2∅, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPV1↑, 2,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD25+↑, 1,   CD4+↑, 1,   CD44↓, 9,   cDC2↓, 4,   p‑cDC2↓, 2,   COX1↓, 1,   COX2/PTGS2↓, 61,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCR2↓, 1,   CXCR4↓, 10,   CXCR4↑, 1,   DR4↑, 9,   DR4∅, 1,   FOXP3↑, 1,   Gal-3↓, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL1↑, 1,   IL10↓, 2,   IL12↓, 1,   IL1α↓, 1,   IL1β↓, 10,   IL2↑, 3,   IL4↓, 1,   IL4↑, 1,   IL6↓, 27,   IL8↓, 4,   Imm↑, 4,   Imm↝, 2,   Inflam↓, 21,   LTA/TNF-β↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   MCT1↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 101,   NF-kB↑, 4,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 1,   NLRP3↑, 1,   NOD1↓, 1,   p50↓, 1,   p65↓, 6,   p‑p65↓, 2,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 3,   PD-1↝, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PGE2↓, 14,   PSA↓, 6,   RAGE↓, 1,   SOCS-3↓, 1,   T-Cell↑, 1,   T-Cell↝, 1,   TCF↓, 1,   TCF↑, 1,   TLR4↓, 4,   TLR4↝, 1,   TNF-α↓, 26,   TNF-α↑, 4,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   IM↓, 1,   pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   SYN1↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 15,   ER-α36↓, 2,   ERα/ESR1↓, 1,   GR↝, 1,   PPARα↓, 2,   PPARγ↓, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 3,   BioAv↓, 27,   BioAv↑, 31,   BioAv↝, 9,   BioEnh↑, 5,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 101,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP3A4↓, 2,   Dose?, 2,   Dose↓, 2,   Dose↑, 4,   Dose⇅, 1,   Dose↝, 38,   Dose∅, 10,   eff↓, 83,   eff↑, 66,   eff↝, 6,   eff∅, 1,   GSTA1↑, 1,   GSTP1/GSTπ↓, 1,   Half-Life↓, 7,   Half-Life↑, 1,   Half-Life↝, 11,   MDR1↓, 4,   MRP1/ABCC1↓, 5,   P-gp/ABCB1↓, 10,   P-gp/ABCB1↑, 1,   P450↓, 3,   RadioS?, 1,   RadioS↑, 30,   selectivity↓, 1,   selectivity↑, 93,   Synergy↑, 73,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 4,   ALP↓, 2,   AR↓, 15,   ascitic↓, 1,   AST↓, 3,   BRAF↓, 2,   BRCA1↓, 1,   CEA↓, 2,   CRP↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 29,   EGFR↑, 2,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 3,   HER2/EBBR2↓, 14,   hTERT/TERT↓, 7,   IL6↓, 27,   KRAS↓, 2,   LDH↓, 2,   LDH↑, 4,   LDH↝, 1,   i-LDH↓, 1,   Myc↓, 4,   NSE↓, 1,   PD-L1↓, 4,   PD-L1↑, 1,   PSA↓, 6,   RAGE↓, 1,   TP53↓, 1,   TP53↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 31,   antiCG↓, 1,   antiD↑, 1,   antiNeop↑, 2,   AntiTum↓, 2,   AntiTum↑, 12,   cachexia↓, 2,   cardioP↑, 5,   CardioT↑, 1,   chemoP↑, 17,   chemoPv↑, 14,   ChemoSideEff↓, 2,   hepatoP↓, 1,   hepatoP↑, 7,   neuroP↑, 5,   NP/CIPN↓, 1,   Obesity↓, 1,   OS↑, 10,   Pain↓, 2,   QoL↑, 2,   radioP↑, 3,   Remission↑, 1,   RenoP↑, 8,   Risk↓, 10,   toxicity?, 1,   toxicity↓, 12,   toxicity↑, 4,   toxicity↝, 9,   TumVol↓, 22,   TumVol↑, 1,   TumW↓, 9,   Weight↑, 1,   Weight∅, 1,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiP↑, 1,   Bacteria↓, 3,   GutMicro↑, 3,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 1014

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 3,   antiOx↑, 41,   i-antiOx↑, 1,   Catalase↑, 22,   GPx↑, 14,   GPx1↑, 1,   GSH↑, 15,   GSR↑, 2,   GSSG∅, 1,   GSTs↑, 9,   H2O2↓, 1,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 11,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 11,   MDA↓, 9,   MPO↓, 1,   NADH↓, 1,   NOX4↓, 1,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 23,   Prx↑, 1,   RNS↓, 3,   ROS↓, 44,   ROS↑, 2,   ROS∅, 4,   mt-ROS?, 1,   SOD↓, 1,   SOD↑, 21,   SOD1↑, 2,   SOD2↑, 2,   TAC↑, 2,   TBARS↓, 1,   uricA↓, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 2,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 2,   ALAT↓, 4,   AMPK↑, 2,   ATP↑, 3,   GAPDH↑, 1,   glucose↓, 4,   glucose↝, 1,   GSK‐3β↓, 2,   LDL↓, 4,   lipidLev↓, 1,   NAD↑, 1,   NADPH↑, 2,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 5,   Apoptosis∅, 1,   mt-Apoptosis↓, 1,   BAX↓, 5,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 2,   Bcl-2↑, 4,   Casp↓, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 7,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 2,   Casp9↓, 1,   Casp9↑, 1,   Casp9∅, 1,   cl‑Casp9↓, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 4,   Cyt‑c∅, 1,   Fas↑, 2,   iNOS↓, 9,   iNOS↑, 1,   p38↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↑, 1,   Akt2↓, 1,   ERK↓, 1,   ERK↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IκB?, 1,   JAK↓, 1,   JNK↓, 3,   JNK↑, 1,   p‑JNK↓, 2,   MAPK↓, 4,   MAPK↑, 1,   mTOR↓, 1,   mTOR↑, 1,   PDGFR-BB↓, 1,   PI3K↓, 2,   PI3K↑, 1,   PKCδ↓, 1,   STAT3↑, 1,   p‑STAT3↑, 1,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cMyc↑, 1,   HOTAIR↑, 1,   other↓, 2,   other↑, 1,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↑, 1,   IRE1↓, 1,   PERK↓, 1,   UPR↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   p16↓, 1,   P53↓, 3,   P53↑, 2,   PARP↓, 3,   PARP↑, 1,   PARP∅, 1,   p‑PARP↓, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 2,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   cycE/CCNE↑, 1,   E2Fs↑, 1,   P21↓, 2,   P21↑, 3,   TumCCA↑, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   AP-1↓, 1,   Ca+2?, 1,   Ca+2↓, 2,   Ca+2↝, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 1,   MMP3↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   E-sel↓, 1,   Hif1a↓, 2,   NO↓, 5,   NO↑, 1,   VCAM-1↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   GastroP↑, 2,   GLUT1↓, 1,   MMP↓, 3,   MMP↑, 3,   MMP∅, 1,   MUC5AC↓, 1,   OCLN↝, 1,   SVCT-2↑, 1,   TJ↑, 1,   TRPA1↑, 1,   TRPC1↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD4+↑, 1,   CD8+↑, 1,   COX1↓, 3,   COX2/PTGS2↓, 16,   COX2/PTGS2↑, 1,   IL10↓, 2,   IL10↑, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 9,   IL6↓, 14,   IL6↑, 1,   IL8↓, 1,   Imm↑, 4,   Imm⇅, 1,   Inflam↓, 49,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 1,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 18,   NLRP3↓, 1,   PAF↓, 1,   PGE2↓, 4,   PGE2↑, 1,   PSA∅, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR1↓, 1,   TLR4↓, 1,   TNF-α↓, 20,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 5,   BChE↓, 2,   BDNF↑, 2,   MAOA↓, 1,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 6,   BACE/β-secretase↓, 2,   tau↓, 2,   p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↓, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 16,   BioAv↑, 23,   BioAv↝, 9,   BioAv∅, 1,   BioEnh↑, 1,   CompStab↑, 1,   Dose↝, 4,   Dose∅, 1,   eff↑, 6,   GSTA1↑, 1,   Half-Life↑, 1,   Half-Life↝, 7,   Half-Life∅, 2,   P450↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALP↓, 2,   AST↓, 5,   BG↓, 1,   BP↓, 4,   creat↓, 1,   CRP↓, 3,   hs-CRP↓, 1,   IL6↓, 14,   IL6↑, 1,   LDH↓, 4,   LDH↑, 1,   NOS2↓, 1,   PSA∅, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 3,   antiAll↑, 14,   AntiArt↑, 7,   AntiCan↑, 8,   AntiDiabetic↑, 9,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 3,   cardioP↑, 15,   chemoP↑, 7,   chemoPv↑, 2,   cognitive↑, 3,   hepatoP↓, 1,   hepatoP↑, 9,   memory↑, 3,   motorD↓, 1,   motorD↑, 1,   neuroP↓, 1,   neuroP↑, 27,   Obesity↓, 6,   Pain↓, 4,   radioP↑, 3,   RenoP↑, 1,   Stress↓, 1,   Stroke↓, 3,   toxicity↓, 24,   toxicity↑, 2,   toxicity↝, 4,   toxicity∅, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 9,   AntiFungal↓, 1,   AntiFungal↑, 2,   AntiP↓, 1,   AntiP↑, 2,   AntiViral↑, 10,   Bacteria↓, 12,   GutMicro↑, 9,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 4,  
Total Targets: 292

Scientific Paper Hit Count for: PARP, poly ADP-ribose polymerase (PARP) cleavage
16 Apigenin (mainly Parsley)
16 Curcumin
15 Fisetin
14 Quercetin
14 Thymoquinone
12 Baicalein
10 EGCG (Epigallocatechin Gallate)
10 Sulforaphane (mainly Broccoli)
8 Honokiol
8 Kaempferol
8 Licochalcone A
8 Shikonin
7 Ashwagandha(Withaferin A)
7 Berberine
7 Capsaicin
7 Emodin
7 Garcinol
7 Magnolol
6 Metformin
6 Boswellia (frankincense)
6 Carnosic acid
6 Chrysin
6 Gambogic Acid
6 isoorientin
6 lambertianic acid
6 Piperlongumine
6 Vitamin C (Ascorbic Acid)
5 doxorubicin
5 Betulinic acid
5 Eugenol
5 Licorice
5 Morin
5 Silymarin (Milk Thistle) silibinin
4 Cisplatin
4 Bufalin/Huachansu
4 α-Bisabolol / Chamomile oil
4 Carvacrol
4 chaetocin
4 Citric Acid
4 Docetaxel
4 Evodiamine
4 Formononetin
4 Fucoidan
4 Ginkgetin
4 Ivermectin
4 Nimbolide
4 Propolis -bee glue
4 Phenethyl isothiocyanate
4 Resveratrol
3 Auranofin
3 Silver-NanoParticles
3 Allicin (mainly Garlic)
3 5-fluorouracil
3 Brucea javanica
3 Thymol-Thymus vulgaris
3 Radiotherapy/Radiation
3 Ellagic acid
3 Ferulic acid
3 HydroxyTyrosol
3 Isobavachalcone
3 phytic acid, Inositol hexakisphosphate
3 Isoliquiritigenin
3 Luteolin
3 Lycopene
3 mebendazole
3 Magnetic Fields
3 Methylsulfonylmethane
3 Propyl gallate
3 α-Santalol/Sandalwood oil
2 1,8-Cineole
2 Artemisinin
2 Berbamine
2 Beta-Caryophyllene
2 temozolomide
2 brusatol
2 Boron
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Cichoric acid / Chicoric acid
2 Cinnamon
2 Cucurbitacin
2 Cynaropicrin
2 Dichloroacetate
2 D-limonene
2 Dandelion Root
2 Echinacea
2 Ginkgo biloba-EGb 761
2 Eurycomanone
2 Flaxseed/Linseed
2 Gallic acid
2 Photodynamic Therapy
2 Hyperoside
2 Rutin
2 Indole-3-carbinol
2 isoquercitrin
2 Juglone
2 methylseleninic acid
2 Phenylbutyrate
2 Paclitaxel/Taxol
2 Piperine
2 Rosmarinic acid
2 salinomycin
2 Selenite (Sodium)
2 Ursolic acid
2 Urolithin
1 3-bromopyruvate
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 immunotherapy
1 Atorvastatin
1 Aloe anthraquinones
1 Baicalin
1 almonertinib
1 Bromelain
1 Bullatacin
1 Butyrate
1 Sorafenib (brand name Nexavar)
1 Cat’s Claw
1 Celastrol
1 Chlorogenic acid
1 Chlorophyllin
1 Coenzyme Q10
1 Carvone
1 Dichloroacetophenone(2,2-)
1 Date Fruit Extract
1 Diindolylmethane
1 Fenbendazole
1 Geldanamycin
1 Radicicol/monorden
1 Bortezomib
1 Flaxseed Oil
1 olaparib/LYNPARZA
1 Gemcitabine (Gemzar)
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Ginkgolide B
1 Ginger/6-Shogaol/Gingerol
1 Gossypol/AT-101
1 Graviola
1 Hydroxycinnamic-acid
1 hydroxychloroquine
1 isoflavones
1 Isovitexin
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lapachol
1 Lasiodin
1 low dose naltrexone
1 Linalool
1 Lutein
1 Methylene blue
1 Matrine
1 Dordaviprone; Modeyso
1 Modified Citrus Pectin
1 Chemotherapy
1 Mistletoe/Viscum album Extracts
1 Mushroom Chaga, Inonotus obliquus
1 Myricetin
1 nelfinavir/Viracept
1 Oleuropein
1 Marjoram (Origanum majorana)
1 SonoDynamic Therapy UltraSound
1 Hyperthermia
1 Plumbagin
1 VitK3,menadione
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Selenium NanoParticles
1 chitosan
1 Folic Acid, Vit B9
1 Osimertinib
1 Adagrasib
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:239  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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