PI3K Cancer Research Results

PI3K, Phosphatidylinositide-3-Kinases: Click to Expand ⟱
Source: HalifaxProj(inhibit) CGL-CS
Type:
Phosphatidylinositol 3-kinase (PtdIns3K or PI3K) is a family of enzymes that play a crucial role in cell signaling pathways, particularly in the regulation of cell growth, survival, and metabolism. The PI3K pathway is one of the most frequently altered pathways in human cancer. Inhibition of the PI3K pathway has been explored as a therapeutic strategy for cancer treatment. Several PI3K inhibitors have been developed and are currently being tested in clinical trials. These inhibitors can target specific components of the pathway, such as PI3K, AKT, or mTOR.

Class I phosphoinositide 3-kinase (PI3K)
Class III PtdIns3K
In contrast to the class III PtdIns3K as a positive regulator of autophagy, class I PI3K-AKT signaling has an opposing effect on the initiation of autophagy.

PI3K inhibitors include:
-Idelalisib , Copanlisib, Alpelisib
-LY294002?
-Wortmannin: potent PI3K inhibitor, has some associated toxicity.
-Quercetin:
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
Scientific Papers found: Click to Expand⟱
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
4837- Uro,    Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review
- Review, Var, NA
AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,
4853- Uro,    Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
- vitro+vivo, PC, MIA PaCa-2 - in-vitro, NA, PANC1
p‑Akt↓, p‑p70S6↓, TumCG↓, OS↑, PI3K↓, mTOR↓, TumCP↓, TumCMig↓, Apoptosis↑, TAMS↓, Treg lymp↓, Wnt↓, IGF-1↓, *toxicity↓, *BioAv↑, Half-Life↝,
4855- Uro,    Urolithins impair cell proliferation, arrest the cell cycle and induce apoptosis in UMUC3 bladder cancer cells
- in-vitro, Bladder, UMUC3
TumCCA↑, PI3K↓, Akt↓, MAPK↓,
3135- VitC,    The interplay between vitamin C and thyroid
- Review, Thyroid, NA
AntiCan↑, ChemoSen↑, radioP↑, MAPK↓, ERK↓, PI3K↓, Akt↓, QoL↑, OS↑,
2365- VitD3,    Vitamin D Affects the Warburg Effect and Stemness Maintenance of Non- Small-Cell Lung Cancer Cells by Regulating the PI3K/AKT/mTOR Signaling Pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H1975 - in-vivo, NA, NA
Glycolysis↓, Warburg↓, GLUT1↓, LDHA↓, HK2↓, PKM2↓, OCT4↓, SOX2↓, Nanog↓, PI3K↓, Akt↓, mTOR↓,
2283- VitK2,    Vitamin K Contribution to DNA Damage—Advantage or Disadvantage? A Human Health Response
- Review, Var, NA
*ER Stress↓, *toxicity↓, *toxicity↑, ROS↑, PI3K↑, Akt↑, Hif1a↑, GlucoseCon↑, lactateProd↑, ChemoSen↑, eff↑, eff↑,
2281- VitK2,    The biological responses of vitamin K2: A comprehensive review
- Review, Var, NA
*ROS↓, *12LOX↓, *NF-kB↓, *BMD↑, *hepatoP↑, cycD1/CCND1↓, PKCδ↓, STAT3↓, ERK↑, MAPK↓, ROS↑, PI3K↝, Akt↝, Hif1a↝, *neuroP↑,
1214- VitK2,    Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82
Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,
2301- Wog,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
HK2↓, PDK1↓, LDHA↓, Hif1a↓, PI3K↓, Akt↓, Glycolysis↓, P53↑, GLUT1↓,

Showing Research Papers: 351 to 360 of 360
Prev Page 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 360

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,   ROS↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   AMPK↑, 1,   cMyc↓, 2,   cMyc↑, 1,   GlucoseCon↑, 2,   Glycolysis↓, 2,   Glycolysis↑, 1,   HK2↓, 2,   HK2↑, 1,   lactateProd↑, 2,   LDHA↓, 2,   LDHA↑, 1,   PDH↓, 1,   PDK1↓, 1,   PKM2↓, 1,   SIRT1↑, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 6,   Akt↑, 2,   Akt↝, 1,   p‑Akt↓, 1,   p‑Akt↑, 1,   Apoptosis↑, 3,   BAX↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   Casp3↑, 1,   MAPK↓, 3,   p38↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑p70S6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 2,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 3,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 2,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 2,   ERK↑, 1,   FOXO1↑, 1,   IGF-1↓, 1,   mTOR↓, 2,   mTORC1↓, 1,   Nanog↓, 1,   OCT4↓, 1,   PI3K↓, 7,   PI3K↑, 2,   PI3K↝, 1,   RAS↓, 1,   SOX2↓, 1,   STAT3↓, 1,   TumCG↓, 2,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

PKCδ↓, 1,   Treg lymp↓, 1,   TumCMig↓, 1,   TumCP↓, 3,   TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   Hif1a↑, 2,   Hif1a↝, 1,   TAMS↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,   GLUT1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 2,   IL1β↓, 1,   IL6↓, 1,   Imm↑, 1,   NF-kB↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 4,   eff↓, 6,   eff↑, 3,   Half-Life↝, 1,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 2,   chemoP↑, 1,   OS↑, 2,   QoL↑, 1,   radioP↑, 1,   toxicity↓, 1,  
Total Targets: 94

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   GPx↑, 1,   lipid-P↓, 1,   ROS↓, 3,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioAv↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   neuroP↑, 2,   toxicity↓, 2,   toxicity↑, 1,  
Total Targets: 21

Scientific Paper Hit Count for: PI3K, Phosphatidylinositide-3-Kinases
18 Quercetin
16 Thymoquinone
13 Curcumin
12 Apigenin (mainly Parsley)
12 Fisetin
10 Berberine
10 Resveratrol
10 Shikonin
9 Baicalein
8 Carvacrol
8 Honokiol
7 Chrysin
7 Cinnamon
7 Eugenol
7 Sulforaphane (mainly Broccoli)
6 Alpha-Lipoic-Acid
6 Dandelion Root
6 Luteolin
6 Magnolol
6 Nimbolide
6 Rosmarinic acid
6 Urolithin
5 5-fluorouracil
5 Anethole/trans-Anethole
5 Cisplatin
5 Capsaicin
5 Chlorogenic acid
5 Lycopene
5 Silymarin (Milk Thistle) silibinin
4 Astragalus
4 Beta-Caryophyllene
4 Carnosic acid
4 Propolis -bee glue
4 diet FMD Fasting Mimicking Diet
4 Ellagic acid
4 Emodin
4 Magnetic Fields
4 Naringin
3 Silver-NanoParticles
3 Allicin (mainly Garlic)
3 Chemotherapy
3 Artemisinin
3 Astaxanthin
3 Bacopa monnieri
3 α-Bisabolol / Chamomile oil
3 Thymol-Thymus vulgaris
3 Centella asiatica / Gotu kola → asiaticoside
3 Selenite (Sodium)
3 Vitamin K2
2 Coenzyme Q10
2 Auranofin
2 Ashwagandha(Withaferin A)
2 Trastuzumab
2 Baicalin
2 Biochanin A
2 Betulinic acid
2 Brucea javanica
2 brusatol
2 Boswellia (frankincense)
2 Celecoxib
2 Citric Acid
2 Radiotherapy/Radiation
2 Ursolic acid
2 Deguelin
2 Diclofenac
2 D-limonene
2 EGCG (Epigallocatechin Gallate)
2 Ferulic acid
2 Gambogic Acid
2 Geraniol
2 Ginseng
2 Myricetin
2 Piperine
2 Plumbagin
2 Parthenolide
2 Pterostilbene
2 Aflavin-3,3′-digallate
1 1,8-Cineole
1 HydroxyCitric Acid
1 Acetyl-l-carnitine
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Ascorbyl Palmitate
1 Aloe anthraquinones
1 almonertinib
1 Berbamine
1 Bufalin/Huachansu
1 borneol
1 Caffeic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celastrol
1 Hydroxycinnamic-acid
1 Cucurbitacin
1 CUSP9
1 Dichloroacetophenone(2,2-)
1 Fucoidan
1 Gallic acid
1 Garcinol
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 Hydrogen Gas
1 HydroxyTyrosol
1 Juglone
1 Licorice
1 Melatonin
1 Metformin
1 Magnetic Field Rotating
1 Neem
1 sericin
1 Phenethyl isothiocyanate
1 doxorubicin
1 Piperlongumine
1 Psoralidin
1 Kaempferol
1 Paclitaxel
1 salinomycin
1 Sanguinarine
1 Selenium NanoParticles
1 Formononetin
1 acetazolamide
1 Turmerones
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:252  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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