PI3K Cancer Research Results

PI3K, Phosphatidylinositide-3-Kinases: Click to Expand ⟱
Source: HalifaxProj(inhibit) CGL-CS
Type:
Phosphatidylinositol 3-kinase (PtdIns3K or PI3K) is a family of enzymes that play a crucial role in cell signaling pathways, particularly in the regulation of cell growth, survival, and metabolism. The PI3K pathway is one of the most frequently altered pathways in human cancer. Inhibition of the PI3K pathway has been explored as a therapeutic strategy for cancer treatment. Several PI3K inhibitors have been developed and are currently being tested in clinical trials. These inhibitors can target specific components of the pathway, such as PI3K, AKT, or mTOR.

Class I phosphoinositide 3-kinase (PI3K)
Class III PtdIns3K
In contrast to the class III PtdIns3K as a positive regulator of autophagy, class I PI3K-AKT signaling has an opposing effect on the initiation of autophagy.

PI3K inhibitors include:
-Idelalisib , Copanlisib, Alpelisib
-LY294002?
-Wortmannin: potent PI3K inhibitor, has some associated toxicity.
-Quercetin:
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
Scientific Papers found: Click to Expand⟱
8341- LDN,    Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy
- Review, Var, NA
OGFr↑, TumCP↓, TumCCA↑, Apoptosis↑, toxicity↝, Half-Life↝, *FasL↓, *Fas↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, survivin↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, ChemoSen↑, chemoP↑, Synergy↑, QoL∅,
8338- LDN,    Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway
- vitro+vivo, Cerv, HeLa - in-vitro, Cerv, SiHa
TumCP↓, TumCMig↓, TumCI↓, PI3K↓, p‑Akt↓, mTOR↓, OGFr↑, Dose↝, *toxicity↝, chemoP↑, ChemoSen↑,
8288- LE,    18 β-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration
- vitro+vivo, CRC, NA
TumCP↓, survivin↓, cl‑PARP↑, TumCMig↓, Wound Healing↓, TumCI↓, MMPs↓, p‑PI3K↓, p‑Akt↓, p‑STAT↓,
8284- LE,    Glycyrrhizic acid from licorice down-regulates inflammatory responses via blocking MAPK and PI3K/Akt-dependent NF-κB signalling pathways in TPA-induced skin inflammation
- in-vivo, Nor, NA
*Ingr↝, *iNOS↓, *COX2/PTGS2↓, *IκB↓, *p65↓, *ERK↓, *p38↓, *MAPK↓, *PI3K↓, *Akt↓, *NF-kB↓,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8282- LE,    Glycyrrhizic Acid Inhibits Proliferation of Gastric Cancer Cells by Inducing Cell Cycle Arrest and Apoptosis
- in-vitro, GC, MGC803 - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901
Ingr↝, TumCP↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, BAX↑, PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, Bcl-2↓, survivin↓, p65↓, p‑PI3K↓, p‑Akt↓,
8274- LE,    Research on the Antiaging Activity of Licorice Water Extract in Aging Mice via Antioxidation, Neuronal Protection, Gut Microbiota Restoration, and PI3K/AKT/mTOR Modulation
- in-vivo, Nor, NA
*AntiAge↑, *GutMicro↑, *p‑PI3K↓, *p‑Akt↓, *p‑mTOR↓, *antiOx?, *cognitive↑, *Dose↝, *GPx↑, *Catalase↑, *SOD↑, *MDA↓, *memory↑,
8277- LE,    Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights
- Review, Var, NA
*antiOx↑, *AntiTum↑, HMGB1↓, COX2/PTGS2↓, PGE2↓, TumCP↓, TumCCA↑, Synergy↑, MMP↓, p‑P53↑, BAX↑, cl‑PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, ROS↑, TumAuto↑, MMP9↓, TumMeta↓, PI3K↓, Akt↓, eff↑, *chemoP↑, *NRF2↑, *NF-kB↓,
8278- LE,    Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology
- Review, Var, NA
*Ingr↝, *AntiCan↑, *AntiDiabetic↑, *AntiBio↑, *Inflam↓, *antiAll↑, *hepatoP↑, *cough?, *SoreThr?, *toxicity↝, *cardioP↑, *BioAv↝, *PGE2↓, *COX2/PTGS2↓, *AntiAg↑, *ROS↓, *NLRP3↓, *NF-kB↓, *AP-1↓, TumCCA↑, Apoptosis↑, TumMeta↑, *Dose↝, *Dose↝, Ingr↝, TumAuto↑, LC3II↑, PI3K↓, Akt↓, mTOR↓, *cognitive↑, *BloodF↑, ChemoSen↑, ROS↓, *chemoP↑, ROS↑, tumCV↓, MMP↓, *AntiBio↑, *toxicity↝,
8281- LE,    A Licorice Roots Extract Induces Apoptosis and Cell Cycle Arrest and Improves Metabolism via Regulating MiRNAs in Liver Cancer Cells
- in-vitro, Liver, NA
Apoptosis↑, TumCCA↑, Let-7↑, miR-34b-5p↑, miR-122-5p↑, miR-126↑, miR-195↑, miR-199↑, miR-206↑, miR-326-5p↑, Hif1a↓, PI3K↓, cMyc↓, AMPK↑, P53↑, Glycolysis↓, HK2↓, LDHA↓, PKM2↓, PPP↓, G6PD↓, GlutaM↓, GLS↓, miR-21↑, miR-221↑, miR-222↑,
2453- LE,    The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors
- Review, Var, NA
HK2↓, PI3K↓, Akt↓, TumCP↓, Glycolysis↓,
8144- LF,    A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway
- Human, AD, NA
*Ach↑, *5HT↑, *TAC↑, *Inflam↓, *Akt↑, *PI3K↑, *Aβ42↓, *LDL↓, *ROS↓, *IL6↓, *HSP90↓, *Casp3↓, *tau↓, *MAPK↓, *PTEN↓, *cognitive↑, *Dose↝,
8294- lign,    Secoisolariciresinol diglucoside induces pyroptosis by activating caspase-1 to cleave GSDMD in colorectal cancer cells
- vitro+vivo, CRC, LoVo - in-vitro, CRC, SW-620 - in-vitro, NA, SW480 - in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116
tumCV↓, Pyro↑, cl‑GSDMD↑, cl‑Casp1↑, ROS↑, p‑PI3K↓, TumCG↓, BAX↑, Cyt‑c↑, PI3K↓, Akt↓,
8326- LIN,    Linalool in cancer pharmacology: pharmacokinetic limitations and preclinical cytotoxic evidence for translational development
- Review, Var, NA
Dose↝, *BioAv↓, BioAv↝, tumCV↓, compI↓, compII↓, ROS↑, ATP↓, GSH↓, mtDam↑, Casp↑, NF-kB↓, MMP↓, TumCCA↑, PI3K↓, Akt↓, angioG↓, CD31/PECAM-1↓, Ki-67↓,
8319- LIN,    Linalool monoterpene exerts potent antitumor effects in OECM 1 human oral cancer cells by inducing sub-G1 cell cycle arrest, loss of mitochondrial membrane potential and inhibition of PI3K/AKT biochemical pathway
- in-vitro, Oral, OECM-1 - in-vitro, Nor, FR-2
tumCV?, selectivity↑, Apoptosis↑, TumCCA↑, p‑PI3K↓, p‑Akt↓, MMP↓,
8395- LT,  PacT,    Luteolin enhances drug chemosensitivity by downregulating the FAK/PI3K/AKT pathway in paclitaxel‑resistant esophageal squamous cell carcinoma
- in-vitro, ESCC, NA
*AntiTum↑, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, EMT↓, ChemoSen↑, PI3K↓, Akt↓, FAK↓,
8378- LT,    Luteolin and its derivatives: modulation of epithelial-mesenchymal transition in fibrosis and cancer
- Review, Var, NA
EMT↓, TGF-β1↓, Smad1↓, PI3K↓, Akt↓, Hippo↝, YAP/TEAD↓, *NRF2↑, *HO-1↑, *ROS↓, E-cadherin↑, ZO-1↑, Vim↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, TCF↓, Zeb1↓, angioG↓, eff↑, ROS↑, mtDam↑, MMP↓, ETC↓,
8377- LT,    Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases
- Review, Asthma, NA
*PI3K↑, *Akt↑, *Inflam↓, *ROS↓, *BioAv↓, *RenoP↑, *cardioP↑, *neuroP↑, *antiAll↑, *AntiDiabetic↑, *hepatoP↑, *AntiThr↑, *toxicity↓, *IL10↓, *Sepsis↓, *TNF-α↓, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *lipid-P↓, *IL4↓, *IL5↓, *PGE2↓, *PI3K↑, *Akt↑, *mTOR↑, *Beclin-1/ATG6↓, *Mucositis↓, *PLA2↓, STAT3↓, PD-L1↓, miR-34a↓, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Bax:Bcl2↑, Apoptosis↑, ROS↑, EMT↓, E-cadherin↓, DR5↑, LIMK1↓, Pain↓,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8386- LT,    Luteolin induces apoptosis in Philadelphia chromosome-positive acute lymphoblastic leukemia cell by regulating the PI3K/AKT signaling pathway
- in-vitro, ALL, SUP-B15
tumCV↓, ROS↑, MMP↓, ATP↓, p‑PI3K↓, p‑Akt↓, p‑STAT3↓, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, TumCP↓, eff↓, ChemoSen↑, FAK↓, Synergy↑, BioAv↓, BioAv↑,
8390- LT,    Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective
- Review, IBD, NA - Review, CRC, NA
*Diff↝, *Inflam↓, *ROS↓, *GutMicro↑, *IBI↑, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, *BioAv↑, *iNOS↓, *TNF-α↓, *IL6↓, *MDA↓, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *Catalase↑, *5HT↓, *TPH1↓, *MAPK↓, *ERK↓, *Inflam↓, cycD1/CCND1↓, CDK4↓, TumCCA↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, E-cadherin↑, N-cadherin↓, Vim↓,
8392- LT,    Revisiting Luteolin Against the Mediators of Human Metastatic Colorectal Carcinoma: A Biomolecular Approach
- in-vitro, CRC, HCT15 - in-vitro, CRC, HCT116 - in-vitro, CRC, DLD1 - in-vitro, CRC, HT-29 - in-vitro, Nor, RWPE-1
selectivity↑, β-catenin/ZEB1↓, GSK‐3β↑, AKT1↓, PI3K↓, p50↓,
8393- LT,    Progress, pharmacokinetics and future perspectives of luteolin modulating signaling pathways to exert anticancer effects: A review
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, EMT↓, Imm↝, ChemoSen↑, *Inflam↓, *COX2/PTGS2↓, *NF-kB↓, MMP2↓, MMP9↓, p‑Akt↓, p‑PI3K↓, IGF-2↓, IGF-1R↓, CXCL16↓, NOTCH1↓, HES1↓, VEGF↓, ROS↑,
8401- LT,    Multi-Faceted Role of Luteolin in Cancer Metastasis: EMT, Angiogenesis, ECM Degradation and Apoptosis
- Review, Var, NA
EMT↓, N-cadherin↓, Vim↓, VEGF↓, VEGFR1↓, MMPs↓, Telomerase↓, NF-kB↓, cMyc↓, Bax:Bcl2↑, Casp3↑, PI3K↓, Akt↓, FOXO3↑, P21↑, p27/CDKN1B↑, cl‑PARP↑, Cyt‑c↑, NOTCH↓, HES1↓, ROS↑, SOD↓, miR-34b-5p↑, Hif1a↓, P21↓, survivin↓, Mcl-1?, Bcl-xL↓, MDM2↓, MMP2↓, MMP9↓, MMP3↓, MMP16↓, miR-384↑, NRF2↓, HO-1↓, angioG↓,
8397- LT,    Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules
- Review, Var, NA
tumCV↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, mTOR↓, PI3K↓, Akt↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Apoptosis↑, hTERT/TERT↓, AP-1↓, NF-kB↓, MAPK↓, HSP90↓, AR↓, IGF-1R↓, Akt↓, NOTCH↓, IL6↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, TumVol∅, TumW∅, miR-34a↑, miR-107↑, miR-139-5p↑, miR-422a↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, *toxicity↓,
2905- LT,    Luteolin blocks the ROS/PI3K/AKT pathway to inhibit mesothelial-mesenchymal transition and reduce abdominal adhesions
- in-vivo, Nor, HMrSV5
*ROS↓, *p‑Akt↓, *Vim↓, *E-cadherin↑, *PI3K↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
8349- Lut,    Lutein Inhibits Cell Growth and Activates Apoptosis via the PI3K/AKT/mTOR Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, HCC827 - in-vitro, Nor, BEAS-2B
*antiOx↑, PI3K↓, Akt↓, Apoptosis↑, selectivity↑,
8350- Lut,    The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: role of H(2)O(2) in NF-kappaB activation
- in-vitro, Nor, NA
*H2O2↓, *NF-kB↓, *iNOS↓, *TNF-α↓, *IL1β↓, *COX2/PTGS2↓, *PI3K↓, *PTEN↓, *NF-kB↓, *Akt↓,
3532- Lyco,    Lycopene alleviates oxidative stress via the PI3K/Akt/Nrf2pathway in a cell model of Alzheimer’s disease
- in-vitro, AD, NA
*ROS↓, *PI3K↑, *Akt↑, *NRF2↑, *antiOx↑, *Aβ↓, *Apoptosis↓, *neuroP↑,
3828- Lyco,    Lycopene alleviates oxidative stress via the PI3K/Akt/Nrf2pathway in a cell model of Alzheimer's disease
- in-vitro, AD, M146L
*ROS↓, *PI3K↑, *Akt↑, *NRF2↓, *antiOx↑, *BACE/β-secretase↓, *MDA↓,
1126- Lyco,    Lycopene Inhibits Epithelial–Mesenchymal Transition and Promotes Apoptosis in Oral Cancer via PI3K/AKT/m-TOR Signal Pathway
- vitro+vivo, Oral, NA
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EMT↓, PI3K↓, Akt↓, mTOR↓, E-cadherin↓, BAX↑, N-cadherin↓, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Bcl-2↓,
8421- Lyco,    Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *AntiMyl↑, *ROS↓, *MMP↑, *NGF↑, *BDNF↑, *VEGF↑, *Aβ42↓, *PI3K↑, *Akt↑, *NRF2↑, *lipid-P↓, *GSH↑, *Catalase↑, *SOD↑, *cognitive↑, *Learn↑, *memory↑, *APP↓, *BACE/β-secretase↓, *ADAM10↑, *NF-kB↓, *AChE↓, *MAOA↓, *BioAv↝,
4800- Lyco,    Recent insights on pharmacological potential of lycopene and its nanoformulations: an emerging paradigm towards improvement of human health
- Review, Var, NA
*antiOx↑, Keap1↝, NF-kB↝, NRF2↝, PI3K↝, Akt↝, mTOR↝, *GutMicro↑,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
8524- MAG,    Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, CRC, HCT116
Apoptosis↑, Akt?, BAD↑, Cyt‑c↑, cl‑Casp8↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, NA⇅, selectivity↑, p‑EGFR↓, p‑PI3K↓, p‑Akt↓,
8521- MAG,    Magnolol induces apoptosis via caspase-independent pathways in non-small cell lung cancer cells
- in-vitro, Lung, A549 - in-vitro, Lung, H520 - in-vitro, Lung, NCI-H441
TumCP↓, DNAdam↑, MMP↓, selectivity↑, BID↑, BAX↑, Cyt‑c↑, AIF↑, Endon↑, cl‑PARP↑, PI3K↓, Akt↓, ERK↓, p38↑, JNK↑,
8505- MAG,    Role of magnolol in gastrointestinal cancers: Recent trends and future perspectives
- Review, GC, NA
TumCP↓, TumCI↓, TumCMig↓, angioG↓, EMT↓, TumCCA↑, Apoptosis↑, PI3K↝, Akt↝, NF-kB↝, MAPK↝, JNK↝, ERK↝, TGF-β↝, Smad1↝,
8516- MAG,    Magnolol induces cell death through PI3K/Akt-mediated epigenetic modifications boosting treatment of BRAF- and NRAS-mutant melanoma
- in-vitro, Melanoma, NA
TumCCA↑, Apoptosis↑, TumCD↑, PI3K↓, Akt↓, H3K4↓, ChemoSen↑,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27/CDKN1B↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
4515- MAG,    Magnolol as a Potential Anticancer Agent: A Proposed Mechanistic Insight
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↑, angioG↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, NF-kB↓,
4535- MAG,  5-FU,    Magnolol and 5-fluorouracil synergy inhibition of metastasis of cervical cancer cells by targeting PI3K/AKT/mTOR and EMT pathways
- in-vitro, Cerv, NA
ChemoSen↑, TumCP↓, vinculin↓, TumCA↓, TumCMig↓, TumCI↓, p‑Akt↓, p‑PI3K↓, mTOR↓, E-cadherin↑, β-catenin/ZEB1↑, Snail↓, Slug↓,
4533- MAG,    Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways
- in-vitro, GC, SGC-7901
AntiCan↑, DNAdam↑, Apoptosis↑, TumCCA↑, Bax:Bcl2↑, MMP↓, Casp3↑, PI3K↓, Akt↓,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
1089- MAG,    Magnolol potently suppressed lipopolysaccharide-induced iNOS and COX-2 expression via downregulating MAPK and NF-κB signaling pathways
- in-vitro, AML, RAW264.7
p‑IκB↓, NF-kB↓, p‑ERK↓, p‑JNK↓, p‑PI3K↓, p‑Akt↓, iNOS↓, COX2/PTGS2↓,
8564- Matr,    Matrine inhibits proliferation and promotes autophagy and apoptosis in non-small cell lung cancer cells by deactivating PI3K/AKT/mTOR pathway
- in-vitro, Lung, A549
TumCP↓, p‑Akt↓, p‑mTOR↓, LC3B↑, PI3K↓, Akt↓, mTOR↓,

Showing Research Papers: 351 to 400 of 562
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 562

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA⇅, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 11,   antiOx⇅, 1,   Catalase↓, 9,   Catalase↑, 2,   Copper↓, 1,   GPx↓, 2,   GPx↑, 1,   GPx4↓, 8,   GSH↓, 21,   GSH↑, 6,   GSH/GSSG↓, 1,   GSR↓, 2,   GSTs↓, 2,   GSTs↑, 2,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 7,   HO-1↑, 14,   hyperG↓, 1,   Iron↑, 2,   i-Iron↑, 1,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↝, 1,   lipid-P↓, 4,   lipid-P↑, 10,   MDA↓, 3,   MDA↑, 8,   MPO↓, 1,   NQO1↓, 2,   NQO1↑, 1,   NRF2↓, 18,   NRF2↑, 16,   NRF2↝, 3,   OSI↑, 1,   PYCR1↓, 2,   RNS↑, 1,   ROS?, 1,   ROS↓, 23,   ROS↑, 213,   ROS⇅, 10,   ROS↝, 4,   i-ROS↓, 1,   mt-ROS↑, 3,   SOD↓, 12,   SOD↑, 6,   SOD1↓, 1,   SOD2↓, 4,   SOD2↑, 2,   TAC↓, 1,   TBARS↑, 1,   Thiols↓, 1,   TKT↝, 1,   TOS↑, 1,   Trx↓, 2,   Trx1↑, 1,   ox-Trx1↑, 1,   TrxR↓, 7,   TrxR1↓, 3,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,   IronCh∅, 1,   STEAP3↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 7,   CDC25↓, 8,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 9,   ETC↓, 3,   HSP60/HSPD1↓, 2,   Insulin↓, 1,   mitResp↓, 2,   mitResp↑, 1,   MKK7↓, 1,   mtDam↑, 17,   OCR↓, 4,   OCR↑, 3,   OXPHOS↓, 2,   OXPHOS↑, 1,   OXPHOS↝, 1,   PDH↓, 1,   PDH↑, 2,   PDH↝, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SIRT3↓, 2,   SIRT3↑, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 7,   AApath↓, 1,   ACC↓, 2,   ACC↑, 1,   ACLY↓, 3,   ACSL4↑, 1,   adiP↑, 1,   ALAT↓, 4,   ALDOA↓, 1,   AminoA↓, 1,   AMPK?, 1,   AMPK↓, 2,   AMPK↑, 27,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 23,   mt-ATP↓, 1,   ATP:AMP↓, 1,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   ECAR↓, 1,   ENO1↓, 2,   p‑ENO1↓, 1,   FABP4↓, 1,   FABP4↑, 1,   FASN↓, 5,   FASN↑, 1,   FBPase↑, 1,   G6PD↓, 2,   GAPDH↓, 1,   GLS↓, 1,   glucoNG↑, 1,   glucose↓, 3,   glucose↝, 1,   GlucoseCon↓, 12,   GlucoseCon↑, 2,   GlutaM↓, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 40,   Glycolysis↑, 1,   p‑GS3Kβ↓, 1,   GSK‐3β↓, 13,   GSK‐3β↑, 10,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 11,   p‑GSK‐3β↑, 1,   H2S↑, 1,   HK1↓, 1,   HK2↓, 18,   HK2↑, 1,   lactateProd↓, 11,   lactateProd↑, 2,   LDHA↓, 9,   LDHA↑, 1,   LDL↓, 2,   lipoGen↓, 1,   MCT4↓, 1,   NADPH↓, 2,   NADPH↑, 2,   O-Glc↓, 1,   PA↑, 1,   PDK1 / PDPK1↓, 8,   PDK3↑, 1,   PFK↓, 3,   PFK1↓, 5,   PFK2↓, 2,   PKM2↓, 21,   PKM2↑, 1,   PPP↓, 1,   R5P↝, 1,   RARα↓, 1,   RARβ↑, 1,   RARγ↑, 1,   p‑S6↓, 1,   SCD1↓, 2,   SIRT1↓, 6,   SIRT1↑, 11,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 2,   TCA↑, 1,   TS↓, 1,   Warburg↓, 11,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 8,   Apoptosis?, 4,   Apoptosis↓, 7,   Apoptosis↑, 246,   Apoptosis↝, 1,   mt-Apoptosis↑, 6,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 4,   BAD↑, 17,   Bak↑, 7,   BAX↓, 4,   BAX↑, 137,   BAX↝, 1,   Bax:Bcl2↑, 26,   Bcl-2↓, 137,   Bcl-2↑, 3,   Bcl-2↝, 1,   Bcl-2∅, 1,   Bcl-xL↓, 28,   Bcl-xL↑, 1,   Bcl-xL↝, 1,   BID↓, 2,   BID↑, 7,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 7,   BNIP3↑, 3,   BNIP3↝, 1,   BOK↑, 1,   Casp↓, 2,   Casp↑, 30,   cl‑Casp↑, 2,   Casp1↓, 2,   Casp1↑, 1,   cl‑Casp1↑, 1,   Casp10↑, 3,   Casp12↑, 2,   cl‑Casp12↑, 1,   Casp2↑, 2,   Casp3↓, 2,   Casp3↑, 133,   Casp3↝, 1,   Casp3∅, 1,   cl‑Casp3↑, 33,   proCasp3↑, 3,   Casp6↑, 1,   Casp7↑, 13,   cl‑Casp7↑, 4,   Casp8↓, 1,   Casp8↑, 31,   Casp8∅, 1,   cl‑Casp8↑, 5,   proCasp8↑, 3,   pro‑Casp8↑, 1,   Casp9↑, 79,   p‑Casp9↑, 1,   cl‑Casp9↑, 13,   proCasp9↓, 1,   proCasp9↑, 2,   cFLIP↓, 6,   Cyt‑c↓, 1,   Cyt‑c↑, 78,   Cyt‑c↝, 1,   mt-Cyt‑c↓, 1,   Diablo↑, 7,   DR5↓, 1,   DR5↑, 32,   Endon↑, 2,   FADD↑, 4,   Fap1↓, 2,   Fas↓, 1,   Fas↑, 21,   FasL↓, 1,   FasL↑, 7,   Ferroptosis↑, 13,   GRP58↓, 1,   GSDMD↑, 1,   cl‑GSDMD↑, 1,   GSDME↑, 1,   IAP1↓, 10,   IAP2/BIRC3↓, 5,   IAP2/BIRC3↑, 1,   ICD↑, 1,   iNOS↓, 14,   Mcl-1?, 1,   Mcl-1↓, 26,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 11,   MDM2↑, 1,   p‑MDM2↓, 1,   MLKL↑, 1,   MOMP↑, 1,   NAIP↓, 1,   Necroptosis↑, 4,   necrosis↑, 2,   NOXA↑, 2,   oncosis↑, 1,   p38↓, 8,   p38↑, 23,   p‑p38↓, 1,   p‑p38↑, 4,   Paraptosis↑, 1,   PUMA↓, 2,   PUMA↑, 4,   Pyro↑, 4,   RIP1↓, 2,   RIP1↑, 1,   p‑RIP1↑, 1,   RIP3↓, 1,   RIP3↑, 1,   survivin↓, 46,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAILR↑, 2,   TumCD↓, 1,   TumCD↑, 15,   XIAP↓, 27,   XIAP↑, 1,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 2,   Akt↓, 363,   Akt↑, 13,   Akt↝, 4,   p‑Akt↓, 91,   p‑Akt↑, 3,   AKT1↓, 5,   Akt2↓, 2,   AMPKα↑, 2,   Cavin3↓, 1,   CIP2A↓, 2,   CK2↓, 5,   cMET↓, 4,   p‑cMET↑, 1,   cSrc↓, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 48,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 6,   ERK↓, 67,   ERK↑, 9,   ERK↝, 1,   p‑ERK↓, 16,   p‑ERK↑, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FGFR4/CD334↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 14,   HGF/c-Met↓, 3,   Hippo↝, 1,   IGF-1R↓, 9,   IGFR↓, 1,   IKKα↓, 6,   IKKα↑, 2,   p‑IKKα↓, 2,   ILK↓, 1,   IP6K1↓, 1,   IκB↓, 1,   IκB↑, 2,   p‑IκB↓, 2,   JAK↓, 10,   JAK1↓, 1,   JAK1↑, 1,   JAK2↓, 11,   JNK↓, 10,   JNK↑, 25,   JNK↝, 2,   p‑JNK↓, 1,   p‑JNK↑, 4,   LIMK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 61,   MAPK↑, 17,   MAPK↝, 2,   p‑MAPK↓, 2,   p‑MAPK↑, 1,   MARK4↓, 2,   MEK↓, 11,   MEK↑, 1,   MKK4↓, 2,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 175,   mTOR↑, 3,   mTOR↝, 2,   p‑mTOR↓, 20,   mTORC2↓, 3,   mTORC2↑, 2,   p70S6↓, 2,   p70S6↑, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 8,   p‑P70S6K↓, 3,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFRA↓, 1,   PI3K?, 1,   PI3K↓, 422,   PI3K↑, 14,   PI3K↝, 6,   p‑PI3K↓, 46,   p‑PI3K↑, 1,   PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 3,   PKCδ↓, 11,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 5,   PTEN↑, 38,   PTEN↝, 1,   Raf↓, 7,   c-Raf↓, 1,   RAS↓, 14,   RET↓, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 5,   Src↓, 3,   Src↑, 1,   p‑Src↓, 1,   STAT↓, 10,   p‑STAT↓, 1,   STAT3↓, 67,   STAT3↑, 3,   p‑STAT3↓, 13,   p‑STAT3↑, 2,   STAT5↓, 2,   STAT6↓, 3,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TSC2↑, 4,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 7,   CBP↓, 3,   cJun↓, 8,   cJun↑, 3,   p‑cJun↑, 1,   cMyc↓, 36,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 10,   DNMT3A↓, 3,   DNMT3B↓, 1,   DNMTs↓, 5,   EZH2↓, 7,   FOXM1↓, 5,   FOXO↑, 2,   FOXO1↓, 4,   FOXO1↑, 3,   FOXO3↓, 3,   FOXO3↑, 8,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 2,   FOXO4↑, 1,   H3↓, 1,   H3↑, 1,   ac‑H3↑, 1,   H3K4↓, 1,   H4↓, 1,   H4↑, 2,   ac‑H4↑, 1,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 14,   HDAC1↓, 7,   HDAC10↓, 1,   HDAC10↑, 1,   HDAC2↓, 5,   HDAC3↓, 4,   HDAC4↓, 2,   HDAC8↓, 3,   HES1↓, 3,   JPT1/HN1↓, 1,   KLF2↓, 1,   KLF5↓, 1,   LINC01116↓, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-122-5p↑, 1,   miR-124-3p↓, 1,   miR-125b↝, 1,   miR-126↑, 2,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-149↑, 1,   miR-155↓, 4,   miR-182-5p↓, 1,   miR-195↑, 1,   miR-199↑, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-206↑, 1,   miR-21↓, 8,   miR-21↑, 2,   miR-218↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-224↓, 2,   miR-29b↑, 2,   miR-326-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↓, 2,   miR-34a↑, 8,   miR-34b-5p↑, 2,   miR-384↑, 2,   miR-422a↑, 2,   miR-429↑, 1,   miR-592↑, 1,   MTA2↓, 2,   Myc↓, 4,   MYCN↓, 1,   n-MYC↓, 1,   NR1D2↓, 1,   OCT4↓, 12,   other?, 1,   other↓, 4,   other↑, 2,   other↝, 10,   PAX2↓, 1,   PCAF↓, 2,   PhotoS↑, 1,   SOX2↓, 7,   SOX4↓, 5,   SUV39H↓, 1,   TCF-4↓, 1,   TFAP2A↓, 1,   tumCV?, 2,   tumCV↓, 62,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 18,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 3,   eIF2α↑, 5,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 37,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 9,   HSP27↓, 4,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 16,   HSP90↑, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↑, 2,   PERK↑, 6,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↑, 6,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↓, 1,   ATG3↑, 3,   ATG5↑, 9,   ATG7↑, 5,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 22,   p‑Beclin-1/ATG6↑, 1,   CTSB↓, 2,   CTSD↓, 2,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 4,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 2,   LC3B-II↑, 3,   LC3I↓, 1,   LC3II↓, 1,   LC3II↑, 17,   p62↓, 7,   p62↑, 5,   PARK2↑, 1,   RUBCN↓, 1,   SESN2↑, 2,   TumAuto?, 1,   TumAuto↓, 3,   TumAuto↑, 58,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   BRCA1↝, 1,   p‑BRCA1↑, 1,   DFF45↓, 1,   DFF45↑, 2,   DNAdam↑, 49,   DNArepair↓, 2,   DNArepair↑, 1,   ERCC3↑, 1,   FEN1↓, 1,   HR↓, 1,   hTERT/TERT↓, 11,   p16↑, 3,   P53?, 1,   P53↓, 5,   P53↑, 89,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 3,   p73↑, 1,   PARP↓, 4,   PARP↑, 23,   p‑PARP↑, 2,   cl‑PARP↑, 66,   PARP1↑, 2,   cl‑PARP1↑, 1,   PCNA↓, 28,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 3,   Telomerase↓, 10,   TOP1↓, 4,   TOP2↓, 2,   TOP2↑, 1,   TP53↑, 2,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↑, 6,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 17,   CDK1↑, 2,   CDK2↓, 37,   CDK2↑, 4,   CDK4↓, 45,   CDK4↑, 5,   p‑CDK4↓, 1,   CDK4/6↓, 2,   CDK6↓, 18,   CDK6↑, 4,   CDK7↓, 1,   CDK8↓, 1,   CDKN1C/p57↓, 1,   CHK1↓, 2,   p‑CHK1↑, 2,   Chk2↓, 1,   p‑Chk2↑, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 11,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 26,   CycB/CCNB1↑, 5,   cycD1/CCND1↓, 78,   cycD1/CCND1↑, 3,   cycD1/CCND1↝, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 17,   cycE/CCNE↑, 1,   cycE1↓, 1,   E2Fs↓, 4,   Ki-67↓, 34,   MAD↓, 1,   mitA↑, 1,   P21?, 1,   P21↓, 4,   P21↑, 55,   P21↝, 1,   p27/CDKN1B↓, 6,   p27/CDKN1B↑, 29,   pRB↓, 4,   p‑pRB↓, 4,   p‑RB1↓, 1,   Securin↓, 1,   TumCCA↓, 5,   TumCCA↑, 196,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   ALDH↓, 6,   ALDH1A1↓, 3,   AXIN1↑, 2,   Axin2↑, 1,   BMP2↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 2,   CD133↓, 8,   CD133↑, 1,   CD34↓, 2,   cFos↓, 7,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 36,   Diff↓, 2,   Diff↑, 3,   EIF4E↓, 2,   EP2↓, 1,   EP4/PTGER4↓, 1,   FGF↓, 3,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 6,   HH↓, 7,   IGF-1↓, 17,   p‑IGF-1↓, 1,   IGF-2↓, 2,   IGFBP1↑, 1,   IGFBP3↓, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 34,   Let-7↓, 1,   Let-7↑, 4,   mTORC1↓, 11,   p‑mTORC1↓, 1,   Nanog↓, 10,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 21,   NOTCH↑, 1,   NOTCH1↓, 16,   NOTCH1↑, 2,   NOTCH3↓, 3,   OGFr↑, 2,   p300↓, 4,   Piezo1↑, 1,   Shh↓, 7,   Smo↓, 3,   TAZ↓, 1,   TumCG?, 1,   TumCG↓, 82,   TumCG↑, 3,   TumCP?, 2,   TumCP↓, 181,   TumCP↑, 3,   tyrosinase↓, 2,   Wnt?, 1,   Wnt↓, 61,   Wnt↑, 1,   Wnt↝, 1,   Wnt/(β-catenin)↓, 7,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AEG1↑, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 14,   AP-1↝, 1,   ASAP2↓, 1,   ATPase↓, 1,   AXL↓, 3,   BACH1↓, 1,   CA↓, 1,   Ca+2↓, 3,   Ca+2↑, 25,   Ca+2↝, 1,   i-Ca+2?, 1,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Chl↓, 1,   Cofilin↓, 3,   p‑Cofilin↑, 2,   COL1↓, 2,   COL3A1↓, 1,   COL4↓, 1,   DLC1↑, 1,   E-cadherin↓, 12,   E-cadherin↑, 49,   EM↑, 1,   EMT↓, 104,   EMT↝, 1,   EpCAM↓, 2,   F-actin↓, 3,   FAK↓, 20,   FAK↑, 1,   p‑FAK↓, 2,   fascin↓, 1,   Fibronectin↓, 4,   Furin↓, 1,   GIT1↓, 1,   GLI2↓, 4,   GLI3↑, 1,   IQGAP3↓, 1,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   KRAS↓, 2,   LAMs↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MET↓, 3,   p‑MET↓, 1,   MMP-10↓, 3,   MMP1↓, 6,   MMP13↓, 2,   MMP15↓, 1,   MMP16↓, 3,   MMP2↓, 102,   MMP2↝, 1,   MMP3↓, 11,   MMP7↓, 11,   MMP9↓, 112,   MMP9↑, 2,   MMPs↓, 36,   MTA1↓, 1,   MUC4↓, 2,   N-cadherin↓, 38,   NCAM↑, 1,   NEDD9↓, 1,   PAK1↓, 1,   PDGF↓, 6,   Rac1↓, 3,   RECK↑, 1,   Rho↓, 3,   Rho↑, 2,   ROCK1↓, 6,   ROCK1↑, 2,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 15,   Smad1↓, 1,   Smad1↝, 1,   SMAD2↓, 2,   SMAD3↓, 4,   SMAD4↓, 2,   Snail?, 2,   Snail↓, 31,   Snail↑, 1,   STAC2↓, 1,   talin↓, 1,   TET1↓, 1,   TET1↑, 2,   TGF-β↓, 18,   TGF-β↑, 2,   TGF-β↝, 1,   TGF-β1↓, 2,   TIMP1↓, 1,   TIMP1↑, 11,   TIMP2↓, 2,   TIMP2↑, 4,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 3,   TumCA↓, 2,   TumCI↓, 96,   TumCMig↓, 98,   TumCMig↑, 2,   TumMeta↓, 78,   TumMeta↑, 4,   TumPF↓, 1,   Twist↓, 22,   Tyro3↓, 1,   uPA↓, 21,   uPAR↓, 2,   Vim?, 1,   Vim↓, 33,   Vim↑, 2,   vinculin↓, 1,   Zeb1↓, 17,   ZEB2↓, 1,   α-SMA↓, 1,   α-SMA↑, 1,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 62,   β-catenin/ZEB1↑, 3,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 93,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   EGR1↑, 2,   Endoglin↑, 1,   eNOS↓, 3,   HIF-1↓, 8,   Hif1a↓, 69,   Hif1a↑, 2,   Hif1a↝, 1,   Hypoxia↓, 1,   LOX1↓, 1,   NO↓, 4,   NO↑, 1,   NO↝, 1,   VCAM-1↓, 2,   VEGF↓, 110,   VEGF↑, 3,   VEGF↝, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 21,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 4,   CLDN1↓, 3,   CLDN1↑, 1,   CLDN2↓, 1,   EPR↑, 1,   GLUT1↓, 17,   GLUT1↑, 2,   GLUT2↓, 2,   GLUT3↑, 1,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 98,   MMP↑, 1,   MPT↑, 6,   OCLN↑, 1,   TJ↑, 1,   TRPM7↓, 4,   TRPV1↑, 2,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD25+↑, 1,   CD4+↑, 2,   CD44↓, 10,   CD47↓, 1,   CD8+↑, 3,   cDC2↓, 1,   COX1↓, 4,   COX2/PTGS2↓, 76,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCL16↓, 1,   CXCR2↓, 1,   CXCR4↓, 12,   CXCR4↑, 1,   DR4↑, 7,   FOXP3↓, 1,   FOXP3↑, 2,   HMGB1↓, 5,   ICAM-1↓, 6,   IFN-γ↓, 2,   IFN-γ↑, 2,   IL1↓, 5,   IL10↓, 6,   IL10↑, 1,   IL12↓, 3,   IL12↑, 2,   IL17↓, 1,   IL1α↓, 1,   IL1β↓, 12,   IL2↓, 2,   IL2↑, 5,   IL22↓, 1,   IL23↓, 1,   IL4↓, 1,   IL6↓, 36,   IL6↑, 1,   IL6↝, 1,   IL8↓, 7,   Imm↑, 11,   Imm↝, 4,   Inflam↓, 29,   Inflam↑, 1,   IRAK1↓, 2,   LRIG1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 4,   MCT1↓, 1,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB?, 1,   NF-kB↓, 171,   NF-kB↑, 3,   NF-kB↝, 3,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 7,   NLRP3↓, 3,   NLRP3↑, 2,   p50↓, 3,   p65↓, 7,   p‑p65↓, 3,   PD-1↓, 4,   PD-L1↓, 9,   PGE2↓, 20,   PSA↓, 7,   PSA↝, 1,   RAGE↓, 2,   SOCS-3↓, 1,   T-Cell↑, 2,   TCF↓, 2,   Th1 response↑, 2,   TLR2↓, 1,   TLR4↓, 3,   TNF-α↓, 30,   TNF-α↑, 4,   TNF-α↝, 1,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRAF2↑, 1,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,   TAMS↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 2,   AhR↓, 1,   AR↓, 14,   AR↑, 1,   AR↝, 1,   CYP19↓, 2,   ERα/ESR1↓, 1,   ERβ/ESR2↑, 1,   Estro↝, 1,   EstroRS/ERS↓, 1,   FGF21↓, 1,   PPARα↑, 2,   PPARγ↓, 1,   PPARγ↑, 6,   PPARγ↝, 1,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 4,   BioAv↓, 31,   BioAv↑, 39,   BioAv↝, 11,   BioEnh?, 1,   BioEnh↑, 6,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 152,   ChemoSen⇅, 1,   ChemoSen↝, 1,   CompStab↓, 4,   CompStab↑, 3,   CompStab↝, 3,   CYP1A1↓, 4,   CYP1A1↑, 2,   CYP1A2↓, 1,   CYP1B1↑, 1,   Dose?, 3,   Dose↓, 1,   Dose↑, 6,   Dose↝, 47,   Dose∅, 5,   eff?, 1,   eff↓, 35,   eff↑, 78,   eff↝, 9,   eff∅, 3,   Half-Life↓, 11,   Half-Life↝, 6,   Half-Life∅, 1,   MDR1↓, 5,   MRP1/ABCC1↓, 4,   P-gp/ABCB1↓, 17,   P450↓, 3,   RadioS↑, 44,   selectivity?, 1,   selectivity↑, 57,   selectivity∅, 1,   Synergy↑, 87,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 4,   ALP↓, 3,   AR↓, 14,   AR↑, 1,   AR↝, 1,   AST↓, 3,   BG↓, 2,   BRCA1↓, 1,   BRCA1↑, 1,   BRCA1↝, 1,   p‑BRCA1↑, 1,   CA125∅, 1,   CEA↓, 1,   CRP↓, 3,   E6↓, 1,   E7↓, 1,   EGFR↓, 48,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 6,   ERα/ESR1↓, 1,   EstroRS/ERS↓, 1,   EZH2↓, 7,   FOXM1↓, 5,   HER2/EBBR2↓, 14,   hTERT/TERT↓, 11,   IL6↓, 36,   IL6↑, 1,   IL6↝, 1,   IRes↓, 1,   KRAS↓, 2,   LDH↓, 6,   LDH↑, 2,   Maspin↑, 1,   Myc↓, 4,   NSE↓, 1,   PD-L1↓, 9,   PSA↓, 7,   PSA↝, 1,   RAGE↓, 2,   TF-Ag↓, 1,   TP53↑, 2,   TRIB3↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 57,   AntiCan⇅, 1,   antiD↑, 1,   AntiDiabetic↑, 1,   antiNeop↑, 5,   AntiTum↓, 2,   AntiTum↑, 15,   Appetite↑, 1,   cachexia↓, 3,   cardioP↑, 8,   chemoP↓, 1,   chemoP↑, 27,   chemoPv↑, 17,   ChemoSideEff↓, 5,   cognitive↑, 1,   fatigue↓, 2,   hepatoP↑, 4,   Mucositis↓, 1,   neuroP↑, 4,   NP/CIPN↓, 2,   OS↑, 13,   Pain↓, 2,   PFS↑, 1,   QoL↑, 8,   QoL∅, 1,   radioP↑, 9,   Remission↑, 1,   RenoP↑, 4,   Risk↓, 10,   Sleep↑, 2,   toxicity↓, 16,   toxicity↑, 1,   toxicity↝, 10,   toxicity∅, 1,   TumVol↓, 25,   TumVol∅, 1,   TumW↓, 13,   TumW∅, 1,   Weight↑, 1,   Weight∅, 2,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   AntiViral↑, 1,   Bacteria↑, 1,   GutMicro↑, 10,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 5,  
Total Targets: 1150

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 2,   antiOx↓, 6,   antiOx↑, 105,   ARE↑, 3,   Catalase↑, 48,   Fenton↓, 1,   GCLC↑, 2,   GCLM↑, 2,   GPx↓, 1,   GPx↑, 33,   GPx1↑, 2,   GPx4↑, 3,   GSH↑, 47,   GSH/GSSG↑, 1,   GSR↑, 6,   GSTs↑, 14,   H2O2↓, 5,   H2O2∅, 1,   HDL↓, 1,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 39,   HO-2↓, 1,   hyperG↓, 1,   hyperG↝, 1,   Iron↓, 1,   Iron∅, 1,   i-Iron↓, 1,   Keap1↓, 4,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 33,   MDA↓, 39,   MDA↑, 2,   MPO↓, 5,   NOX↓, 1,   NOX1↓, 1,   NOX2↓, 1,   NOX4↓, 2,   NQO1↑, 6,   Nrf1↑, 1,   NRF2?, 1,   NRF2↓, 2,   NRF2↑, 75,   RNS↓, 5,   ROS?, 1,   ROS↓, 129,   ROS↑, 1,   ROS∅, 1,   mt-ROS?, 1,   SOD↓, 1,   SOD↑, 57,   SOD1↑, 5,   SOD2↑, 1,   TAC↑, 4,   TBARS↓, 2,   Trx↑, 1,   Trx1↑, 1,   uricA↓, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↓, 1,   IronCh↑, 7,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↑, 1,   MFN2↑, 1,   mtDam↓, 1,   OCR↑, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   SIRT3↑, 1,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 5,   5LO↝, 1,   ALAT↓, 13,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 15,   AMPK⇅, 1,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↑, 6,   Buty↑, 1,   cAMP↑, 1,   cytoP450↓, 1,   DGAT1↓, 1,   FAO↑, 1,   FASN↓, 3,   FFA/NEFA↓, 1,   glucose↓, 6,   glucose↑, 2,   glucose↝, 2,   GlucoseCon↑, 4,   GSK‐3β↓, 7,   GSK‐3β↑, 4,   p‑GSK‐3β↑, 1,   H2S↑, 1,   LDHA↑, 1,   LDL↓, 6,   lipidLev↓, 2,   NAD↑, 1,   NADPH↓, 2,   NADPH∅, 1,   PFK↓, 1,   PKM2↓, 1,   PLA2↓, 1,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 7,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 13,   ASC↓, 1,   BAX↓, 6,   BAX↑, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 2,   Bcl-2↑, 7,   Bcl-xL↑, 1,   Casp↓, 1,   Casp1↓, 2,   Casp12↓, 1,   Casp3↓, 14,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 2,   cl‑Casp8↓, 1,   Casp9↓, 4,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   Fas↓, 1,   FasL↓, 1,   Ferroptosis↓, 3,   GranB/GZMB↓, 1,   iNOS↓, 17,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 3,   p38↑, 2,   RIP1↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 19,   Akt↑, 50,   Akt↝, 2,   p‑Akt↓, 4,   p‑Akt↑, 4,   Akt2↓, 1,   CREB↑, 3,   p‑CREB↑, 1,   EGFR↓, 1,   ERK↓, 4,   ERK↑, 10,   p‑ERK↑, 2,   IKKα↓, 2,   IκB?, 1,   IκB↓, 1,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAPK↓, 20,   MAPK↑, 7,   MAPK↝, 2,   mTOR↓, 6,   mTOR↑, 11,   mTOR↝, 1,   p‑mTOR↓, 2,   p‑P70S6K↑, 1,   PI3K↓, 25,   PI3K↑, 54,   PI3K↝, 2,   p‑PI3K↓, 3,   p‑PI3K↑, 1,   PKA↑, 2,   PKCδ↑, 3,   PP2A↑, 3,   PTEN↓, 4,   PTEN↑, 2,   PTP1B↓, 1,   RAS↓, 1,   STAT↓, 2,   STAT3↓, 2,   STAT3↑, 3,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 6,   ATF2↑, 1,   ATF4↓, 1,   cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO1↝, 1,   FOXO3↑, 1,   HDAC↓, 1,   HOTAIR↑, 1,   miR-107↑, 1,   other↓, 2,   other↑, 6,   other↝, 8,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   p‑eIF2α↓, 1,   ER Stress↓, 4,   GRP78/BiP↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   HSP90↑, 1,   HSPs↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3II↑, 1,   MitoP↑, 1,   p62↓, 2,   p62↑, 3,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   DNArepair↑, 2,   p16↓, 2,   P53↓, 2,   PARP1↓, 1,   PCNA↓, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   Ki-67↑, 1,   P21↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↑, 1,   Jun↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 3,   NOTCH1↑, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 12,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 3,   Cartilage↑, 2,   COL1↓, 1,   COL1↑, 1,   E-cadherin↑, 1,   Fibrosis↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP3↓, 1,   MMP9↓, 6,   Rho↓, 1,   SLIT2↑, 1,   TGF-β↓, 4,   TGF-β↑, 1,   TGF-β1↓, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   Vim↓, 1,   α-SMA↓, 4,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 3,   CD31/PECAM-1↓, 2,   E-sel↓, 1,   eNOS↑, 3,   Hif1a↓, 5,   Hif1a↑, 2,   NO↓, 7,   VCAM-1↓, 6,   VEGF↓, 6,   VEGF↑, 2,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 14,   BBB↝, 1,   GastroP↑, 1,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 4,   H+/K+-ATPase↓, 1,   IBI↑, 4,   MMP↑, 12,   MMP∅, 1,   MUC5AC↓, 1,   NHE3↑, 1,   OCLN↝, 1,   TJ↑, 2,   TRPC1↓, 1,   TRPM7↓, 1,   VGSC↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD25+↑, 1,   CD4+↑, 2,   COX1↓, 3,   COX2/PTGS2↓, 35,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 4,   IL10↑, 4,   IL12↓, 1,   IL17↓, 4,   IL18↓, 3,   IL1β↓, 28,   IL2↓, 1,   IL23↓, 1,   IL4↓, 4,   IL4↑, 1,   IL5↓, 3,   IL6?, 1,   IL6↓, 41,   IL8↓, 6,   Imm↑, 10,   Imm⇅, 2,   Inflam↓, 121,   Inflam↑, 1,   IRF3↓, 1,   LPS↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MyD88↓, 2,   NeuroI↓, 1,   NF-kB↓, 62,   NF-kB↑, 1,   NLRP3↓, 10,   NLRP3↑, 1,   p65↓, 1,   PGE1↓, 1,   PGE2↓, 14,   RAGE↓, 2,   SOCS-3↓, 1,   TLR2↓, 2,   TLR4↓, 8,   TNF-α↓, 47,   Treg lymp↝, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 5,   Ach↑, 4,   AChE↓, 22,   AChE↑, 1,   ADAM10↑, 2,   BChE↓, 3,   BDNF↑, 14,   ChAT↑, 1,   GABA↑, 2,   MAOA↓, 7,   MAOB↓, 2,   NGF↑, 5,   TPH1↓, 1,   TrkB↓, 1,   TrkB↑, 6,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 4,   Aβ↓, 22,   Aβ42↓, 3,   BACE/β-secretase↓, 10,   BACE/β-secretase↑, 1,   IDE↑, 1,   PSEN1/PS1↓, 1,   tau↓, 7,   p‑tau↓, 9,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   CYP19↓, 1,   GLP-1R↑, 1,   GR↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 4,   p‑PPARγ↓, 1,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 34,   BioAv↑, 31,   BioAv↝, 30,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 1,   Dose↓, 2,   Dose↑, 3,   Dose⇅, 1,   Dose↝, 18,   eff↓, 1,   eff↑, 11,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 2,   Half-Life↓, 2,   Half-Life↝, 8,   Half-Life∅, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 13,   ALP↓, 2,   AST↓, 16,   BloodF↑, 2,   BMD↑, 3,   BP↓, 4,   BP↝, 1,   creat↓, 2,   CRP↓, 7,   EGFR↓, 1,   Ferritin↑, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 41,   IRes↓, 1,   IRes↑, 1,   IRes↝, 1,   LDH↓, 7,   LDH↑, 1,   RAGE↓, 2,   SpO2↑, 1,   TP53↑, 1,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 3,   AntiAge↑, 5,   antiAll↑, 18,   AntiArt↑, 9,   AntiCan↑, 17,   antiCG↑, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 26,   AntiMyl↑, 1,   antiPs↑, 3,   AntiTum↓, 1,   AntiTum↑, 7,   Bone Healing↑, 1,   cardioP?, 1,   cardioP↑, 40,   CardioT↓, 1,   chemoP↑, 8,   chemoPv↑, 6,   cognitive↑, 31,   cough?, 1,   diuretic↑, 3,   fatigue↓, 2,   hepatoP↑, 41,   Learn?, 1,   Learn↑, 3,   memory?, 1,   memory↑, 32,   motorD↑, 4,   Mucositis↓, 2,   neuroP↑, 95,   Obesity↓, 11,   OS↑, 1,   Pain↓, 4,   radioP↑, 6,   RenoP↓, 1,   RenoP↑, 13,   Risk↓, 2,   SoreThr?, 1,   Strength↑, 2,   Stroke↓, 11,   toxicity?, 1,   toxicity↓, 25,   toxicity↑, 2,   toxicity↝, 9,   toxicity∅, 4,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 8,   AntiFungal↑, 3,   AntiP↑, 4,   AntiViral↑, 10,   Bacteria↓, 16,   Bacteria↑, 1,   GutMicro↑, 16,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 8,  
Total Targets: 501

Scientific Paper Hit Count for: PI3K, Phosphatidylinositide-3-Kinases
21 Fisetin
19 Quercetin
18 Thymoquinone
16 Kaempferol
16 Luteolin
13 Apigenin (mainly Parsley)
13 Curcumin
12 Matrine
11 Inositol
11 Resveratrol
10 Berberine
10 Magnolol
10 Shikonin
9 Baicalein
9 Licorice
8 5-fluorouracil
8 Carvacrol
8 Formononetin
8 Honokiol
8 Sulforaphane (mainly Broccoli)
7 Isovitexin
7 Chrysin
7 Cinnamon
7 Eugenol
7 Isoliquiritigenin
7 Licochalcone A
7 Melatonin
6 Alpha-Lipoic-Acid
6 Cisplatin
6 Dandelion Root
6 Emodin
6 Garcinol
6 Vitexin
6 Lycopene
6 Nimbolide
6 Rosmarinic acid
6 Urolithin
5 Anethole/trans-Anethole
5 Capsaicin
5 Chlorogenic acid
5 Fucoidan
5 Gambogic Acid
5 Ginseng
5 phytic acid, Inositol hexakisphosphate
5 isoorientin
5 Silymarin (Milk Thistle) silibinin
4 Astragalus
4 Beta-Caryophyllene
4 Carnosic acid
4 Propolis -bee glue
4 diet FMD Fasting Mimicking Diet
4 Indole-3-carbinol
4 Ellagic acid
4 Ferulic acid
4 Hyperoside
4 Magnetic Fields
4 Naringin
3 Silver-NanoParticles
3 Allicin (mainly Garlic)
3 Chemotherapy
3 Artemisinin
3 Astaxanthin
3 Bacopa monnieri
3 α-Bisabolol / Chamomile oil
3 Thymol-Thymus vulgaris
3 Centella asiatica / Gotu kola → asiaticoside
3 Radiotherapy/Radiation
3 Diindolylmethane
3 Gallic acid
3 Ginkgolide B
3 Hydrogen Gas
3 HydroxyTyrosol
3 isoquercitrin
3 itraconazole
3 Paclitaxel/Taxol
3 Morin
3 Selenite (Sodium)
3 Vitamin K2
2 Coenzyme Q10
2 Auranofin
2 Ashwagandha(Withaferin A)
2 Trastuzumab
2 Baicalin
2 Biochanin A
2 Betulinic acid
2 Brucea javanica
2 brusatol
2 Boswellia (frankincense)
2 Celecoxib
2 chaetocin
2 Hydroxycinnamic-acid
2 Citric Acid
2 Ursolic acid
2 Deguelin
2 Diclofenac
2 D-limonene
2 EGCG (Epigallocatechin Gallate)
2 Evodiamine
2 Geraniol
2 Ginger/6-Shogaol/Gingerol
2 Hibiscus sabdariffa
2 Inulin Prebiotic
2 Ivermectin
2 low dose naltrexone
2 Linalool
2 Lutein
2 Metformin
2 doxorubicin
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Myricetin
2 Piperine
2 Plumbagin
2 Parthenolide
2 Pterostilbene
2 Aflavin-3,3′-digallate
1 1,8-Cineole
1 HydroxyCitric Acid
1 Acetyl-l-carnitine
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Ascorbyl Palmitate
1 Aloe anthraquinones
1 almonertinib
1 Berbamine
1 Bufalin/Huachansu
1 borneol
1 Caffeic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celastrol
1 Cucurbitacin
1 CUSP9
1 Dichloroacetophenone(2,2-)
1 Sorafenib (brand name Nexavar)
1 flavonoids
1 Bortezomib
1 Flaxseed/Linseed
1 chitosan
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Ginkgetin
1 hydrogen sulfide
1 Isobavachalcone
1 Juglone
1 lambertianic acid
1 Lasiodin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Mung Bean Sprouts
1 mebendazole
1 Magnetic Field Rotating
1 Magnesium
1 Moringa oleifera
1 Mushroom Chaga, Inonotus obliquus
1 Neem
1 sericin
1 Phenethyl isothiocyanate
1 Phenolic Acids
1 Piperlongumine
1 Psoralidin
1 Rhein
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Sanguinarine
1 Selenium NanoParticles
1 acetazolamide
1 Docetaxel
1 Turmerones
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:252  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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