| Source: HalifaxProj (inhibit) |
| Type: |
| A signal protein produced by many cells that stimulates the formation of blood vessels.
Vascular endothelial growth factor (VEGF) is a signal protein that plays a crucial role in angiogenesis, the process by which new blood vessels form from existing ones. This process is vital for normal physiological functions, such as wound healing and the menstrual cycle, but it is also a key factor in the growth and spread of tumors in cancer. Because of its significant role in tumor growth and progression, VEGF has become a target for cancer therapies. Anti-VEGF therapies, such as monoclonal antibodies (e.g., bevacizumab) and small molecule inhibitors, aim to inhibit the action of VEGF, thereby reducing blood supply to tumors and limiting their growth. These therapies have been used in various types of cancer, including colorectal, lung, and breast cancer. |
| 3369- | QC, | Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects |
| - | Review, | Pca, | NA |
| 3372- | QC, | FIS, | KaempF, | Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers |
| - | Review, | HNSCC, | NA |
| 3603- | QC, | Mechanism of quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus |
| - | Review, | AD, | NA | - | Review, | Diabetic, | NA |
| 66- | QC, | Emerging impact of quercetin in the treatment of prostate cancer |
| - | Review, | Pca, | NA |
| 910- | QC, | The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism |
| 923- | QC, | Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health |
| - | Review, | Var, | NA |
| 2687- | RES, | Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs |
| - | Review, | NA, | NA | - | Review, | AD, | NA |
| 3082- | RES, | Resveratrol Ameliorates the Malignant Progression of Pancreatic Cancer by Inhibiting Hypoxia-induced Pancreatic Stellate Cell Activation |
| - | in-vitro, | PC, | PANC1 | - | in-vitro, | PC, | MIA PaCa-2 | - | in-vivo, | NA, | NA |
| 3080- | RES, | Resveratrol: A miraculous natural compound for diseases treatment |
| - | Review, | Var, | NA |
| 3076- | RES, | Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells |
| - | Review, | Var, | NA |
| 3089- | RES, | The Role of Resveratrol in Cancer Therapy |
| - | Review, | Var, | NA |
| 3092- | RES, | Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action |
| - | Review, | BC, | MDA-MB-231 | - | Review, | BC, | MCF7 |
| 3071- | RES, | Resveratrol and Its Anticancer Effects |
| - | Review, | Var, | NA |
| 3055- | RES, | Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets |
| - | Review, | Var, | NA |
| 2987- | RES, | Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1 |
| - | in-vivo, | Nor, | NA |
| 7150- | RES, | Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity |
| - | Review, | Var, | NA |
| 3013- | RosA, | Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro |
| - | in-vitro, | NA, | NA |
| 3003- | RosA, | Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases |
| - | Review, | Var, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
| 4900- | Sal, | Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications |
| - | Review, | BC, | NA |
| 1209- | SANG, | Sanguinarine is a novel VEGF inhibitor involved in the suppression of angiogenesis and cell migration |
| - | in-vitro, | Lung, | A549 |
| 3192- | SFN, | Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention |
| - | in-vitro, | Pca, | PC3 |
| 963- | SFN, | Sulforaphane inhibits hypoxia-induced HIF-1α and VEGF expression and migration of human colon cancer cells |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | GC, | AGS |
| 110- | SFN, | Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway |
| - | in-vivo, | PC, | NA |
| 1434- | SFN, | GEM, | Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity |
| - | in-vitro, | CCA, | HuCCT1 | - | in-vitro, | CCA, | HuH28 | - | in-vivo, | NA, | NA |
| 1508- | SFN, | Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment |
| - | Review, | Var, | NA |
| 1484- | SFN, | Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
| 1729- | SFN, | Discovery and development of sulforaphane as a cancer chemopreventive phytochemical |
| - | Review, | Nor, | NA |
| 1732- | SFN, | Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | BC, | SUM159 | - | in-vivo, | NA, | NA |
| 1726- | SFN, | Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential |
| - | Review, | Var, | NA |
| 1725- | SFN, | Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway |
| - | Review, | Var, | NA |
| 3300- | SIL, | Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy |
| - | Review, | Var, | NA |
| 3301- | SIL, | Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid |
| - | Review, | Var, | NA |
| 3288- | SIL, | Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations |
| - | Review, | Var, | NA |
| 3282- | SIL, | Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions |
| - | Review, | NA, | NA |
| 3326- | SIL, | Silymarin suppresses proliferation of human hepatocellular carcinoma cells under hypoxia through downregulation of the HIF-1α/VEGF pathway |
| - | in-vitro, | Liver, | HepG2 | - | in-vitro, | Liver, | Hep3B |
| 3323- | SIL, | Anticancer therapeutic potential of silibinin: current trends, scope and relevance |
| - | Review, | Var, | NA |
| 3314- | SIL, | Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review |
| - | Review, | NA, | NA |
| 2197- | SK, | Shikonin derivatives for cancer prevention and therapy |
| - | Review, | Var, | NA |
| 2188- | SK, | Molecular mechanism of shikonin inhibiting tumor growth and potential application in cancer treatment |
| - | Review, | Var, | NA |
| 1192- | SM, | Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1 |
| - | in-vitro, | GC, | AGS | - | in-vitro, | Liver, | HepG3 |
| 1688- | SSE, | Potential Role of Selenium in the Treatment of Cancer and Viral Infections |
| - | Review, | Var, | NA |
| 5075- | SSE, | Sodium selenite inhibits proliferation and metastasis through ROS‐mediated NF‐κB signaling in renal cell carcinoma |
| - | vitro+vivo, | RCC, | 786-O |
| 5112- | SSE, | https://pubmed.ncbi.nlm.nih.gov/19811770/ |
| - | in-vitro, | Pca, | PC3 |
| 1202- | Tb, | The influence of theobromine on angiogenic activity and proangiogenic cytokines production of human ovarian cancer cells |
| - | in-vitro, | Ovarian, | NA |
| 5331- | TFdiG, | Anti-Cancer Properties of Theaflavins |
| - | Review, | Var, | NA |
| 5222- | TQ, | Thymoquinone chemosensitizes colon cancer cells through inhibition of NF-κB |
| - | in-vitro, | CRC, | COLO205 | - | in-vitro, | CRC, | HCT116 |
| 7942- | TQ, | Thymoquinone inhibits inflammation, neoangiogenesis and vascular remodeling in asthma mice |
| - | in-vitro, | Asthma, | NA |
| 2125- | TQ, | Thymoquinone Selectively Kills Hypoxic Renal Cancer Cells by Suppressing HIF-1α-Mediated Glycolysis |
| - | in-vitro, | RCC, | RCC4 | - | in-vitro, | RCC, | Caki-1 |
| 2127- | TQ, | Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways |
| - | Review, | GBM, | NA |
| 2138- | TQ, | Thymoquinone has a synergistic effect with PHD inhibitors to ameliorate ischemic brain damage in mice |
| - | in-vivo, | Nor, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:334 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid