VEGF Cancer Research Results

VEGF, Vascular endothelial growth factor: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
A signal protein produced by many cells that stimulates the formation of blood vessels. Vascular endothelial growth factor (VEGF) is a signal protein that plays a crucial role in angiogenesis, the process by which new blood vessels form from existing ones. This process is vital for normal physiological functions, such as wound healing and the menstrual cycle, but it is also a key factor in the growth and spread of tumors in cancer.
Because of its significant role in tumor growth and progression, VEGF has become a target for cancer therapies. Anti-VEGF therapies, such as monoclonal antibodies (e.g., bevacizumab) and small molecule inhibitors, aim to inhibit the action of VEGF, thereby reducing blood supply to tumors and limiting their growth. These therapies have been used in various types of cancer, including colorectal, lung, and breast cancer.
Scientific Papers found: Click to Expand⟱
2095- TQ,    Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis
- Review, Var, NA
TumCCA↑, Apoptosis↑, ROS↑, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, cl‑PARP↑, P53↑, P21↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, COX2↓, MMP9↓, VEGF↓, eff↑,
2100- TQ,    Dual properties of Nigella Sative: Anti-oxidant and Pro-oxidant
- Review, NA, NA
ROS⇅, *antiOx↑, *SOD↑, *MPO↑, *neuroP↑, *chemoP↑, *radioP↑, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, COX2↓, MMP9↓, VEGF↓, ROS↑, P21↑, HDAC↓, GSH↓, GADD45A↑, AIF↑, STAT3↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3425- TQ,    Advances in research on the relationship between thymoquinone and pancreatic cancer
Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27↑, P21↑, ChemoSen↑,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,
3420- TQ,    Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway
- in-vitro, Nor, HUVECs - in-vitro, NA, NA
*NF-kB↓, *NLRP3↓, *angioG↑, *MMP9↑, *VEGF↑, *OS↑, *Pyro?, *ROS↓, *Apoptosis↓, *SIRT1↑, *SOD1↑, *HO-1↑, *eNOS↑, *ASC?, *Casp1↓, *IL1β↓, *IL18↓,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3573- TQ,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, Var, NA
NF-kB↓, XIAP↓, PI3K↓, Akt↓, STAT3↓, JAK2↓, cSrc↓, PCNA↓, MMP2↓, ERK↓, Ki-67↓, Bcl-2↓, VEGF↓, p65↓, COX2↓, MMP9↓,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
4859- Uro,  Rad,    Urolithin A Enhances Tight Junction Protein Expression in Endothelial Cells Cultured In Vitro via Pink1-Parkin-Mediated Mitophagy in Irradiated Astrocytes
- in-vitro, Nor, NA
*ROS↓, *VEGF↓,
3146- VitC,    Vitamin C protects against hypoxia, inflammation, and ER stress in primary human preadipocytes and adipocytes
- in-vivo, Nor, NA
*Obesity↓, *ER Stress↓, *Inflam↓, Hif1a↓, VEGF↓, GLUT1↓, GRP78/BiP↓,
3107- VitC,    Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment
- Review, Var, NA
Risk↓, *ROS↓, ROS↑, VEGF↓, COX2↓, ER Stress↑, IRE1↑, JNK↑, CHOP↑, Hif1a↓, eff↑, Glycolysis↓, MMPs↓, TumMeta↓, YAP/TEAD↓, eff↑, TET1↑,
1740- VitD3,    Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms
- Review, Var, NA
Risk↓, eff↑, eff↑, Risk↓, Risk↓, ChemoSen↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp9↑, hTERT/TERT↓, eff↑, E-cadherin↑, CLDN2↑, ZO-1↑, Snail↓, Zeb1↓, Vim↓, VEGF↓, NK cell↑, Risk↓, eff↑,
961- Z,    Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo
- in-vitro, RCC, RCC4 - vitro+vivo, GBM, U373MG - in-vitro, Nor, HUVECs
Hif1a↓, HIF-1↓, VEGF↓, TumCI↓,

Showing Research Papers: 351 to 365 of 365
Prev Page 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 365

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   ROS↑, 6,   ROS⇅, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   CDC2↓, 1,   CDC25↓, 1,   mitResp↓, 1,   MMP↓, 1,   XIAP↓, 5,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   ATG7↑, 1,   cMyc↓, 2,   Glycolysis↓, 2,   PKM2↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 6,   Akt↑, 1,   Apoptosis↑, 5,   Bak↑, 1,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Bcl-2↑, 1,   Bcl-xL↓, 3,   BID↓, 1,   Casp↑, 1,   Casp3↑, 5,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 5,   Chk2↓, 1,   Cyt‑c↑, 3,   DR5↑, 1,   Fas↑, 1,   hTERT/TERT↓, 2,   IAP1↓, 2,   IAP2↓, 2,   iNOS↓, 2,   JNK↑, 4,   MAPK↓, 2,   MAPK↑, 2,   Mcl-1↓, 1,   Myc↓, 1,   p27↑, 3,   p38↑, 3,   survivin↓, 5,   TRAIL↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

H4↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↑, 1,   eIF2α↓, 1,   ER Stress↑, 1,   GRP78/BiP↓, 1,   IRE1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3II↑, 2,   p62↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   BRCA1↑, 1,   CHK1↓, 1,   CYP1B1↑, 1,   DNAdam↑, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   GADD45A↑, 1,   p16↑, 1,   P53↑, 4,   cl‑PARP↑, 2,   PCNA↓, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 3,   E2Fs↓, 1,   E2Fs↑, 1,   P21↑, 6,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD34↓, 1,   cMET↓, 1,   CSCs↓, 1,   EMT↓, 2,   ERK↓, 5,   p‑ERK↓, 1,   FOXO↑, 1,   GSK‐3β↓, 2,   HDAC↓, 3,   HDAC1↓, 2,   HDAC4↓, 1,   Jun↓, 1,   mTOR↓, 4,   NOTCH↓, 2,   P70S6K↓, 1,   PI3K↓, 6,   PTEN↑, 3,   STAT3↓, 5,   TumCG↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AP-1↓, 1,   CLDN2↑, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 2,   FAK↓, 2,   ITGA5↓, 1,   Ki-67↓, 2,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 5,   MMPs↓, 3,   MUC4↓, 1,   N-cadherin↓, 2,   Slug↓, 1,   Snail↓, 2,   TET1↑, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TumCI↓, 2,   TumCP↓, 3,   TumMeta↓, 5,   Twist↓, 3,   Vim↓, 3,   Zeb1↓, 3,   ZO-1↑, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 2,   HIF-1↓, 1,   Hif1a↓, 4,   VEGF↓, 12,   VEGFR2↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 6,   CXCL1↓, 1,   CXCR4↓, 1,   IL1↓, 1,   IL10↓, 1,   IL12↓, 1,   IL2↑, 1,   IL6↓, 1,   Inflam↓, 2,   JAK2↓, 2,   MCP1↓, 1,   NF-kB↓, 5,   p‑NF-kB↑, 1,   NK cell↑, 1,   p65↓, 2,   TNF-α↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   ChemoSen↑, 4,   Dose↝, 1,   eff↑, 7,   RadioS↑, 1,   selectivity↑, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BRCA1↓, 1,   BRCA1↑, 1,   GutMicro↑, 1,   hTERT/TERT↓, 2,   IL6↓, 1,   Ki-67↓, 2,   Maspin↑, 1,   Myc↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   chemoP↑, 1,   hepatoP↑, 1,   RenoP↑, 1,   Risk↓, 5,  
Total Targets: 174

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 1,   GSTA1↑, 1,   H2O2↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   MPO↑, 1,   NRF2↑, 1,   ROS↓, 4,   SOD↑, 3,   SOD1↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   LDH↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Casp1↓, 1,   Casp3↓, 1,   iNOS↑, 1,   JNK↑, 1,   MAPK↑, 1,   Pyro?, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Migration(tgid=13) ⓘ

MMP13↓, 1,   MMP9↓, 1,   MMP9↑, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   eNOS↑, 1,   VEGF↓, 2,   VEGF↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC?, 1,   COX2↓, 2,   CRP↓, 1,   IL10↑, 1,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 3,   IL6↓, 1,   Inflam↓, 3,   MyD88↓, 1,   NF-kB↓, 2,   PGE2↓, 1,   TLR2↓, 1,   TLR4↓, 1,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,   IL6↓, 1,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 2,   Obesity↓, 1,   OS↑, 1,   radioP↑, 1,   RenoP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

IRF3↓, 1,  
Total Targets: 72

Scientific Paper Hit Count for: VEGF, Vascular endothelial growth factor
16 Thymoquinone
15 Apigenin (mainly Parsley)
15 Curcumin
14 Magnetic Fields
13 EGCG (Epigallocatechin Gallate)
11 Betulinic acid
11 Sulforaphane (mainly Broccoli)
10 Resveratrol
10 Quercetin
9 Baicalein
9 Berberine
9 Chrysin
8 Propolis -bee glue
7 Silver-NanoParticles
7 Artemisinin
7 Boswellia (frankincense)
7 Fisetin
7 Silymarin (Milk Thistle) silibinin
6 Radiotherapy/Radiation
6 Garcinol
5 Beta-Caryophyllene
5 Chlorogenic acid
5 Ellagic acid
5 Honokiol
4 Ashwagandha(Withaferin A)
4 Caffeic acid
4 Cinnamon
4 Deguelin
4 D-limonene
4 Luteolin
4 Nimbolide
4 Phenethyl isothiocyanate
3 Alpha-Lipoic-Acid
3 Cisplatin
3 Chemotherapy
3 Bevacizumab (brand Avastin)
3 Boron
3 Capsaicin
3 Carvacrol
3 Crocetin
3 Emodin
3 Eugenol
3 Fucoidan
3 Ferulic acid
3 Hydrogen Gas
3 Juglone
3 Lycopene
3 Magnolol
3 Melatonin
3 Naringin
3 Piperine
3 Selenite (Sodium)
2 Biochanin A
2 Thymol-Thymus vulgaris
2 Celecoxib
2 Celastrol
2 Cucurbitacin
2 Ursolic acid
2 Diclofenac
2 Gambogic Acid
2 Gemcitabine (Gemzar)
2 Ginger/6-Shogaol/Gingerol
2 Proanthocyanidins
2 Hydroxycinnamic-acid
2 HydroxyTyrosol
2 Methylsulfonylmethane
2 Phenylbutyrate
2 Piperlongumine
2 Rosmarinic acid
2 Shikonin
2 Vitamin C (Ascorbic Acid)
1 1,8-Cineole
1 Auranofin
1 Astragalus
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 Andrographis
1 Ascorbyl Palmitate
1 Astaxanthin
1 Aloe anthraquinones
1 beta-glucans
1 immunotherapy
1 Baicalin
1 Berbamine
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Centella asiatica / Gotu kola → asiaticoside
1 chitosan
1 Coenzyme Q10
1 Vitamin E
1 Carvone
1 Dandelion Root
1 Docetaxel
1 Gallic acid
1 Paclitaxel
1 Genistein (soy isoflavone)
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Grapeseed extract
1 itraconazole
1 mebendazole
1 metronomic chemo
1 Mushroom Shiitake, AHCC
1 Myricetin
1 Niclosamide (Niclocide)
1 Neem
1 Oleuropein
1 Plumbagin
1 VitK3,menadione
1 Psoralidin
1 Pterostilbene
1 Kaempferol
1 salinomycin
1 Sanguinarine
1 Salvia miltiorrhiza
1 Theobromine
1 Aflavin-3,3′-digallate
1 Urolithin
1 Vitamin D3
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:334  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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