VEGF Cancer Research Results

VEGF, Vascular endothelial growth factor: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
A signal protein produced by many cells that stimulates the formation of blood vessels. Vascular endothelial growth factor (VEGF) is a signal protein that plays a crucial role in angiogenesis, the process by which new blood vessels form from existing ones. This process is vital for normal physiological functions, such as wound healing and the menstrual cycle, but it is also a key factor in the growth and spread of tumors in cancer.
Because of its significant role in tumor growth and progression, VEGF has become a target for cancer therapies. Anti-VEGF therapies, such as monoclonal antibodies (e.g., bevacizumab) and small molecule inhibitors, aim to inhibit the action of VEGF, thereby reducing blood supply to tumors and limiting their growth. These therapies have been used in various types of cancer, including colorectal, lung, and breast cancer.
Scientific Papers found: Click to Expand⟱
8663- MLT,    Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect
- vitro+vivo, RCC, 786-O
TumCG↓, ROS↑, TAC↓, TCA↑, Glycolysis↓, OCR↑, ATP↑, MMP↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, VEGFR1↓, eff↓, Synergy↑, Warburg↓, TumCP↓, SOD↓, GSH↓, Catalase↓, GPx↑, Warburg↓, OXPHOS↑, Hif1a↓, VEGF↓, Ki-67↓, Akt↓, mTOR↓,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
1776- MLT,    Therapeutic strategies of melatonin in cancer patients: a systematic review and meta-analysis
- Review, Var, NA
Remission↑, OS↑, neuroP↑, VEGF↓, KISS1↑, TumCP↓, ChemoSideEff↓, radioP↑, Dose∅, *ROS↓, DNArepair↑, ROS↑,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
971- MLT,    Melatonin down-regulates HIF-1 alpha expression through inhibition of protein translation in prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP
Hif1a↓, VEGF↓, p‑p70S6↓,
8911- MO,    Anticancer Potential of Moringa Oleifera in Lung Cancer: A Mini Review of In vitro and In vivo Evidence
- Review, Lung, NA
tumCV↓, Apoptosis↑, BAX↑, Bcl-2↓, Cyt‑c↑, Casp↑, NF-kB↓, EGFR↓, STAT3↓, VEGF↓, eff↑, CD4+↑, CD8+↑,
8777- MSM,  Tam,    The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts
- in-vitro, BC, MCF7 - in-vitro, BC, T47D
tumCV↓, TumCMig↓, JAK2↓, STAT5↓, ChemoSen↑, cycD1/CCND1↓, VEGF↓, IGF-1↓, IGF-1R↓, MMP2↓, MMP3↓, MMP9↓, TumVol↓, STAT3↓,
8765- MSM,    Combination of AG490, a Jak2 inhibitor, and methylsulfonylmethane synergistically suppresses bladder tumor growth via the Jak2/STAT3 pathway
- vitro+vivo, Bladder, NA
*toxicity↓, tumCV↓, TumCMig↓, TumCG↓, STAT3↓, STAT5↓, IGF-1R↓, VEGF↓, VEGFR2/KDR/Flk1↓, TumMeta↓, Synergy↑,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *Synergy↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,
1203- MSM,    Methylsulfonylmethane Suppresses Breast Cancer Growth by Down-Regulating STAT3 and STAT5b Pathways
- vitro+vivo, BC, MDA-MB-231
tumCV↓, STAT3↓, STAT5↓, IGF-1↓, Hif1a↓, VEGF↓, Brk/PTK6↓, IGF-1R↓,
8809- MT/VAE,  Cisplatin,    Synergistic Effects of Mistletoe Lectin and Cisplatin on Triple-Negative Breast Cancer Cells: Insights from 2D and 3D In Vitro Models
- in-vitro, BC, MDA-MB-231
TumCP↓, Apoptosis↑, TumCCA↑, VEGF↓, Hif1a↓,
930- MushShi,    Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation
- in-vitro, Ovarian, NA
p‑STAT3↓, PTPN6↑, cycD1/CCND1↓, Bcl-2↓, Mcl-1↓, survivin↓, VEGF↓,
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, Var, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2/PTGS2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,
1799- NarG,    Naringenin as potent anticancer phytocompound in breast carcinoma: from mechanistic approach to nanoformulations based therapeutics
- Review, BC, NA
TumCCA↑, BioAv↑, Half-Life∅, TNF-α↓, Casp8↑, BAX↑, Bak↑, EGF↓, mTOR↓, PI3K↓, ERK↓, Akt↓, NF-kB↓, VEGF↓, angioG↓, antiOx↑, EMT↓, OS↑, MAPK↓, ChemoSen↑, MMP9↓, MMP2↓, ROS↑, ROS↑, GSH↓, Casp3↑, ROS↑,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, Var, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2/PTGS2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp/ABCB1↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
4225- NarG,    Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury
- in-vivo, AD, NA
*motorD↑, *BDNF↑, *VEGF↑, *Bax:Bcl2↓, *Casp3↓, *Apoptosis↓, *eff↑,
1270- NCL,  Rad,    Niclosamide enhances the antitumor effects of radiation by inhibiting the hypoxia-inducible factor-1α/vascular endothelial growth factor signaling pathway in human lung cancer cells
- in-vivo, Lung, NA
Hif1a↓, VEGF↓,
6775- Neem,  Nimb,    Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment
- Review, Nor, NA
*antiOx↑, P53↑, PTEN↑, NF-kB↓, PI3K↓, Akt↓, Bcl-2↓, VEGF↓, *Inflam↓, *COX2/PTGS2↓, *5LO↝, *Wound Healing↑, *Imm↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, *AntiViral↑, *Bacteria↑, *AntiBio↑, *AntiFungal↑, cMyc↓, BAX↓, IAP1↓, IAP2/BIRC3↓, Bcl-xL↓, survivin↓, XIAP↓, angioG↓,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2/PTGS2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
6493- Nimb,    Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proinflammatory Microenvironment
- in-vivo, CRC, HCT116 - vitro+vivo, CRC, HT29
TumCP↓, Apoptosis↑, NF-kB↓, IKKα↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, cMyc↓, cycD1/CCND1↓, MMP9↓, CXCR4↓, ICAM-1↓, VEGF↓, angioG↓, TumCG↓,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP/DDIT3↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27/CDKN1B↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
8425- OM,    Anti-metastatic and anti-tumor growth effects of Origanum majorana on highly metastatic human breast cancer cells: inhibition of NFκB signaling and reduction of nitric oxide production
- vitro+vivo, BC, MDA-MB-231
TumCCA↑, Apoptosis↑, E-cadherin↑, TumCMig↓, MMP2↓, MMP9↓, uPAR↓, ICAM-1↓, VEGF↓, p‑IκB↓, NF-kB↓, NO↓, TumCG↓, TumMeta↓,
959- PACs,    Grape seed extract inhibits VEGF expression via reducing HIF-1α protein expression
- in-vitro, GBM, U251 - in-vitro, BC, MDA-MB-231
Hif1a↓, p‑Akt↓, p‑S6K↓, p‑S6↓, VEGF↓,
2064- PB,  Rad,    Phenylbutyrate Attenuates the Expression of Bcl-XL, DNA-PK, Caveolin-1, and VEGF in Prostate Cancer Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
Bcl-xL↓, Cav1↓, VEGF↓, RadioS↑, chemoP↑, HDAC↓, *toxicity↓, Diff↑, Prot↓,
2028- PB,    Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
- Review, Var, NA
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP/DDIT3↑, AR↓, other?,
3259- PBG,    Propolis and its therapeutic effects on renal diseases: A review
- Review, Nor, NA
*Inflam↓, *COX2/PTGS2↓, *ROS↓, *NO↓, *NF-kB↓, TumCP↓, angioG↓, VEGF↓, STAT↓, Hif1a↓, RenoP↑, TLR4↓, *MDA↓, *GSH↑, *SOD↑, *Catalase↑, *toxicity∅,
1673- PBG,    An Insight into Anticancer Effect of Propolis and Its Constituents: A Review of Molecular Mechanisms
- Review, Var, NA
TumCP↓, Apoptosis↑, TumCCA↑, MALAT1↓, P53↑, RadioS↑, OS↑, ROS↑, NF-kB↓, p65↑, MMP↓, ROS↑, MMP9↓, β-catenin/ZEB1↓, Vim↓, E-cadherin↓, VEGF↓, EMT↓,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, ChemoSen↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2/PTGS2↓, eff↑, Bax:Bcl2↑,
1662- PBG,    The immunomodulatory and anticancer properties of propolis
- Review, Var, NA
IL6↓, IL12↓, IL10↑, CSCs↓, PAK1↓, VEGF↓, MMP2↓, MMP9↓, NF-kB↓, Hif1a↓, ChemoSen↑, RadioS↑,
1666- PBG,    Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
- Review, Var, NA
ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2/PTGS2↑, ER(estro)↓, cycA1/CCNA1↓, CycB/CCNB1↓, CDK2↓, P21↑, p27/CDKN1B↑, hTERT/TERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,
4930- PEITC,    Targeted anti-cancer therapy: Co-delivery of VEGF siRNA and Phenethyl isothiocyanate (PEITC) via cRGD-modified lipid nanoparticles for enhanced anti-angiogenic efficacy
- vitro+vivo, Lung, A549
VEGF↓, Hif1a↓, TumCG↓, TumCP↓,
4939- PEITC,    Phenethyl Isothiocyanate Inhibits Angiogenesis In vitro and Ex vivo
- in-vitro, Pca, PC3 - ex-vivo, Nor, HUVECs
Risk↓, angioG↓, VEGF↓, TumCMig↓, Akt↓, EGF↓, TumCMig↓,
5185- PEITC,  SFN,    Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells
- in-vitro, Pca, PC3
NF-kB↓, p65↓, VEGF↓, cycD1/CCND1↓, Bcl-xL↓, IKKα↓,
5187- PEITC,    Phenethyl Isothiocyanate Inhibits Migration and Invasion of Human Gastric Cancer AGS Cells through Suppressing MAPK and NF-κB Signal Pathways
- in-vitro, GC, AGS
TumMeta↓, ERK↓, MKK7↓, PKCδ↓, Rho↓, uPA↓, MMP2↓, MMP9↓, RAS↓, VEGF↓, FAK↓, iNOS↓, COX2/PTGS2↓, TumCP↓,
1163- PI,    VEGF_and_E-cadherin_Expression_in_Breast_Cancer_MCF-7_Cell_Line">The Effect of Piperine on MMP-9, VEGF, and E-cadherin Expression in Breast Cancer MCF-7 Cell Line
- in-vitro, BC, MC38
tumCV↓, VEGF↓, MMP9↓, E-cadherin↓,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *Synergy↑, *BioEnh↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑, *antiAll↑,
3597- PI,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, AD, NA - Review, Park, NA - Review, Var, NA
*NF-kB↓, *MAPK↓, *AP-1↓, *COX2/PTGS2↓, *NOS2↓, *IL1β↓, *TNF-α↓, *PGE2↓, *STAT3↓, *IL10↑, *IL4↓, *IL5↓, P53↑, MMP9↓, MMP2↓, cMyc↓, VEGF↓, STAT3↓, survivin↓, p65↓, *antiAll↑,
2999- PL,    Piperlongumine alleviates corneal allograft rejection via suppressing angiogenesis and inflammation
- in-vivo, Nor, HUVECs
*Inflam↓, *angioG↓, *Hif1a↓, *VEGF↓, *ICAM-1↓, *VCAM-1↓, *neuroP↑,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
5160- PLB,  VitK3,    Plumbagin, Vitamin K3 Analogue, Suppresses STAT3 Activation Pathway through Induction of Protein Tyrosine Phosphatase, SHP-1: Potential Role in Chemosensitization
- in-vitro, Melanoma, U266
STAT3↓, cSrc↓, JAK1↓, JAK2↓, SHP1↑, cycD1/CCND1↓, Bcl-xL↓, VEGF↓, Casp3↑, cl‑PARP↑, TumCCA↑, ChemoSen↑,
4968- PSO,    Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer
- in-vitro, Cerv, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiDiabetic↑, *Bacteria↓, AntiTum↑, CSCs↓, ROS↑, TumAuto↑, Apoptosis↑, ChemoSen↑, RadioS↑, BioAv↓, *cardioP↑, *ROS↓, *LDH↓, TumCP↓, TRAIL⇅, TumCMig↓, EMT↓, NF-kB↓, P53↑, Casp3↑, NOTCH↓, CSCs↓, angioG↓, VEGF↓, Ki-67↓, CD31/PECAM-1↓, TRAILR↑, MMP↓, BioAv↓, BioAv↑,
4694- PTS,    Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions
- Review, Var, NA
BioAv↑, AntiCan↑, Casp↑, TumCCA↑, angioG↓, TumMeta↓, MMP9↓, VEGF↓, CSCs↓, CD44↓, cMyc↓, ChemoSen↑, mTOR↓,
2341- QC,    Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
MMP2↓, MMP9↓, VEGF↓, Glycolysis↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, TumAuto↑, Akt↓, mTOR↓, TumMeta↓, MMP3↓, eff↓, GlucoseCon↓, lactateProd↓, TumAuto↑, LC3B-II↑,
3353- QC,    Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
- in-vitro, Oral, KON - in-vitro, Nor, MRC-5
tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, Synergy↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1/ATG6↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
3372- QC,  FIS,  KAE,    Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers
- Review, HNSCC, NA
ROCK1↑, TumCCA↓, HSPs↓, RAS↓, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Endon↑, MMP9↓, MMP2↓, MMP7↓, MMP-10↓, VEGF↓, NF-kB↓, p65↓, iNOS↓, COX2/PTGS2↓, uPA↓, PI3K↓, FAK↓, MEK↓, ERK↓, JNK↓, p38↓, cJun↓, FOXO3↑,
3603- QC,    Mechanism of quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus
- Review, AD, NA - Review, Diabetic, NA
*MAPK↓, *neuroP↑, *ROS↓, *Akt↓, *PI3K↓, *IL6↓, *TNF-α↓, *VEGF↓, *EGFR↓, *Casp3↓, *Bcl-2↓, *IL1β↓,

Showing Research Papers: 351 to 400 of 466
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 466

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 8,   antiOx⇅, 1,   ARE↓, 1,   Catalase↓, 8,   Catalase↑, 4,   Copper↑, 1,   Fenton↑, 1,   GPx↓, 3,   GPx↑, 4,   GPx4↓, 4,   GSH↓, 26,   GSH↑, 5,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 2,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 9,   HO-1↑, 15,   HO-2↓, 1,   Iron↑, 1,   Iron∅, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 9,   MDA↓, 5,   MDA↑, 4,   MPO↓, 2,   NADH↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 2,   NQO1↑, 3,   NRF2↓, 24,   NRF2↑, 24,   NRF2↝, 1,   p‑NRF2↓, 1,   OSI↑, 1,   Prx4↑, 1,   PrxI↓, 1,   PYCR1↓, 1,   ROMO1↑, 1,   ROS?, 1,   ROS↓, 16,   ROS↑, 175,   ROS⇅, 12,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 11,   SOD↑, 6,   SOD2↓, 4,   TAC↓, 3,   Thiols↓, 1,   TOS↑, 1,   Trx1↑, 1,   ox-Trx1↑, 1,   TrxR↓, 5,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR-ABL↓, 1,   CDC2↓, 8,   CDC25↓, 8,   EGF↓, 6,   ETC↓, 2,   HSP60/HSPD1↓, 2,   mitResp↓, 4,   MKK7↓, 2,   Mortalin↓, 1,   mtDam↑, 10,   OCR↓, 3,   OCR↑, 2,   OXPHOS↓, 2,   OXPHOS↑, 3,   PINK1↑, 1,   SIRT3↓, 2,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 6,   AApath↓, 1,   ACC↑, 2,   ALAT↓, 5,   ALAT↑, 1,   ALAT↝, 1,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 20,   p‑AMPK↑, 1,   p‑AMT/GCST/T-protein↑, 1,   ARG↓, 1,   ATP↓, 14,   ATP↑, 1,   ATP↝, 1,   i-ATP↓, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 2,   CAIX/CA9↑, 1,   CYP4A/CYP4A11/CYP4A22↓, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 1,   FABP5/E-FABP↓, 1,   FASN↓, 7,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↓, 1,   GlucoseCon↓, 10,   GlutMet↓, 1,   Glycolysis↓, 31,   GSK‐3β↓, 11,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 7,   HK2↓, 12,   IDO1↓, 1,   lactateProd↓, 11,   lactateProd↑, 1,   e-lactateProd↓, 1,   LDHA↓, 9,   LDL↓, 1,   MCT4↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 11,   PDK3↑, 1,   PFK↓, 1,   PKM2↓, 11,   PKM2↑, 1,   p‑S6↓, 2,   SCD1↓, 1,   SIRT1↓, 6,   SIRT1↑, 8,   SIRT2↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 2,   TCA↑, 1,   TS↓, 1,   Warburg↓, 7,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 152,   Apoptosis↝, 1,   mt-Apoptosis↑, 2,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 2,   BAD↓, 3,   BAD↑, 9,   Bak↑, 11,   BAX↓, 2,   BAX↑, 86,   BAX⇅, 1,   BAX↝, 1,   BAX∅, 1,   Bax:Bcl2↑, 26,   Bcl-2↓, 116,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-2∅, 1,   Bcl-xL↓, 41,   Bcl-xL↝, 1,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 4,   BIM↓, 1,   BIM↑, 4,   BNIP3↑, 3,   BNIP3↝, 1,   Casp↓, 1,   Casp↑, 33,   Casp↝, 1,   cl‑Casp↑, 1,   Casp1↓, 2,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 2,   Casp3?, 1,   Casp3↓, 3,   Casp3↑, 118,   Casp3↝, 1,   cl‑Casp3↑, 17,   proCasp3↑, 1,   Casp6↑, 1,   Casp7?, 1,   Casp7↑, 16,   cl‑Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 29,   cl‑Casp8↑, 6,   proCasp8↑, 1,   Casp9?, 1,   Casp9↑, 69,   cl‑Casp9↑, 9,   proCasp9↓, 1,   cFLIP↓, 5,   Cyt‑c↑, 67,   Cyt‑c↝, 3,   mt-Cyt‑c↓, 1,   Diablo↑, 10,   DIDO1/DIO-1↑, 1,   DR5↑, 21,   Endon↑, 1,   FADD↑, 3,   Fas↑, 22,   FasL↑, 6,   Ferroptosis↑, 7,   GSDME↑, 1,   HEY1↓, 2,   IAP1↓, 14,   IAP1↑, 1,   IAP2/BIRC3↓, 7,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICAD↑, 1,   iNOS↓, 21,   JWA↑, 1,   Mcl-1?, 1,   Mcl-1↓, 29,   MDM2↓, 9,   MDM2↑, 1,   p‑MDM2↓, 2,   MOMP↑, 2,   Necroptosis↑, 4,   necrosis↑, 3,   NOXA↑, 4,   oncosis↑, 1,   p38↓, 10,   p38↑, 16,   p‑p38↓, 3,   p‑p38↑, 3,   PUMA↑, 5,   Pyro↑, 3,   RIP1↑, 2,   RIP3↑, 2,   survivin↓, 68,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAIL⇅, 1,   TRAILR↑, 4,   TumCD?, 1,   TumCD↑, 6,   TUNEL↑, 1,   XIAP?, 1,   XIAP↓, 35,   XIAP↑, 1,   YAP/TEAD↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 135,   Akt↑, 4,   Akt↝, 1,   Akt∅, 1,   p‑Akt↓, 36,   BRAF↓, 1,   Brk/PTK6↓, 1,   CK2↓, 5,   cMET↓, 3,   p‑cMET↑, 2,   cSrc↓, 3,   DYRK1B↓, 1,   EGFR↓, 45,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 2,   ERK↓, 52,   ERK↑, 7,   ERK↝, 1,   ERK∅, 1,   p‑ERK↓, 16,   p‑ERK↑, 2,   ERK5↓, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 9,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 6,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 14,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 2,   p‑IκB↓, 1,   JAK↓, 3,   JAK1↓, 4,   p‑JAK1↓, 1,   JAK2↓, 17,   p‑JAK2↓, 3,   JNK↓, 6,   JNK↑, 20,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 29,   MAPK↑, 12,   MAPK↝, 1,   MARK4↓, 1,   MEK↓, 10,   MKK4↓, 2,   mTOR↓, 81,   mTOR↝, 1,   p‑mTOR↓, 9,   mTORC2↓, 1,   p‑p70S6↓, 2,   P70S6K↓, 5,   p‑P70S6K↓, 2,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 106,   PI3K↝, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 1,   p‑PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 11,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 30,   PTEN↝, 1,   p‑PTEN↓, 1,   PTPN6↑, 1,   Raf↓, 7,   e-Raf↓, 1,   RAS↓, 10,   RAS↑, 1,   p‑S6K↓, 2,   SHP1↑, 4,   Sp1/3/4↓, 17,   Src↓, 4,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 3,   STAT3↓, 86,   p‑STAT3↓, 20,   p‑STAT3↑, 3,   STAT5↓, 4,   STAT6↓, 3,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 5,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 5,   cJun↑, 1,   cMyc↓, 46,   p‑cMyc↑, 1,   DNMT1↓, 7,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 8,   EZH2↓, 2,   FOXM1↓, 6,   FOXO↑, 2,   FOXO1↓, 2,   FOXO3↓, 5,   FOXO3↑, 5,   FOXO3↝, 1,   FOXO4↓, 2,   H3↓, 1,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 3,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 2,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 27,   HDAC1↓, 5,   HDAC2↓, 2,   HDAC3↓, 2,   HDAC4↓, 1,   HDAC8↓, 2,   HES1↓, 2,   HOTAIR↓, 1,   KISS1↑, 1,   miR-10a-5p↝, 1,   miR-133a-3p↑, 1,   miR-134↑, 1,   miR-155↝, 1,   miR-194↑, 1,   miR-200b↑, 2,   miR-200c↑, 1,   miR-203↓, 1,   miR-203↑, 1,   miR-21↓, 5,   miR-21↑, 1,   miR-21↝, 1,   miR-210↓, 1,   miR-210↑, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-30a-5p↑, 1,   miR-34a↑, 3,   miR-34a↝, 1,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-548ah-5p↑, 1,   Myc↓, 9,   MYCN↓, 1,   n-MYC↓, 1,   NDRG1↑, 1,   NEAT1↓, 1,   OCT4↓, 7,   other?, 1,   other↓, 1,   other↑, 3,   other↝, 6,   other∅, 1,   PAX2↓, 1,   PCAF↓, 1,   PhotoS↑, 1,   Prot↓, 1,   SOX2↓, 7,   SOX4↓, 1,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   SUV39H↓, 2,   TFAP2A↓, 1,   tumCV↓, 29,   tumCV∅, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 24,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 2,   eIF2α↑, 2,   p‑eIF2α↑, 2,   ER Stress↓, 2,   ER Stress↑, 29,   GRP78/BiP↓, 3,   GRP78/BiP↑, 9,   HSP27↓, 3,   HSP27↑, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP90↓, 11,   HSPs↓, 2,   HTRA↓, 2,   IRE1↑, 2,   PERK↑, 3,   p‑PERK↑, 1,   UPR↑, 7,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 5,   ATG5↝, 1,   ATG7↑, 2,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 14,   Beclin-1/ATG6↝, 1,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 1,   LC3B-II↑, 3,   LC3II↓, 2,   LC3II↑, 12,   LC3s↑, 1,   p62↓, 9,   p62↑, 3,   PARK2↑, 1,   RUBCN↓, 1,   TumAuto↓, 1,   TumAuto↑, 28,   TumAuto⇅, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATM?, 1,   ATM↑, 1,   p‑ATM↑, 2,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA1↝, 1,   BRCA2↓, 1,   BRCA2↑, 1,   DFF45↓, 2,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 45,   DNArepair↓, 3,   DNArepair↑, 2,   m-FAM72A↓, 1,   HR↓, 1,   hTERT/TERT↓, 14,   p16↑, 5,   P53?, 1,   P53↓, 4,   P53↑, 74,   P53↝, 1,   p‑P53↓, 1,   p‑P53↑, 4,   PARP↓, 3,   PARP↑, 18,   PARP↝, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 57,   PARP1↑, 3,   cl‑PARP1↑, 1,   PCNA↓, 28,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 15,   TOP1↓, 9,   TOP2↓, 6,   TOP2↑, 2,   TP53↓, 1,   TP53↑, 3,   UHRF1↓, 1,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 7,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 37,   CDK2↑, 1,   CDK4↓, 46,   CDK4↑, 1,   CDK4/6↓, 2,   CDK6↓, 21,   CDK6↑, 1,   CDK8↓, 2,   CDKN1C/p57↑, 1,   CHK1↓, 3,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 1,   p‑Chk2↑, 2,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 8,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 20,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 82,   cycD1/CCND1↑, 1,   cycD1/CCND1↝, 1,   CycD3↓, 2,   cycE/CCNE↓, 15,   cycE/CCNE↑, 2,   cycE1↓, 2,   cycF↓, 1,   E2Fs↓, 5,   E2Fs↑, 1,   GADD45A↓, 1,   GADD45A↑, 1,   Ki-67↓, 24,   mitA↑, 2,   P21↓, 4,   P21↑, 55,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 27,   pRB↑, 1,   p‑pRB↓, 2,   RB1↑, 1,   p‑RB1↓, 6,   TubPol↓, 1,   TumCCA↓, 6,   TumCCA↑, 151,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 1,   ALDH↓, 4,   BMP2↓, 1,   BMP7/OP1↓, 1,   BMPs↑, 3,   CD133↓, 5,   CD133↑, 1,   CD24↓, 1,   CD34↓, 2,   cFos↓, 3,   cFos↑, 1,   cMYB↓, 2,   CSCs↓, 39,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 4,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 10,   HH↓, 7,   IGF-1?, 1,   IGF-1↓, 11,   IGF-2↓, 1,   IGFBP3↑, 5,   Jun↓, 1,   Ki-67↓, 24,   Let-7↑, 5,   MCM2↓, 1,   mTORC1↓, 2,   p‑mTORC1↓, 1,   Nanog↓, 6,   Nestin↓, 3,   NICD↓, 1,   NOTCH↓, 17,   NOTCH1↓, 12,   NOTCH1↑, 3,   NOTCH3↓, 3,   p300↓, 2,   PTCH1↓, 3,   PTCH2↓, 1,   SCF↓, 2,   Shh↓, 11,   Smo↓, 6,   STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TumCG↓, 79,   TumCG↑, 2,   TumCP?, 1,   TumCP↓, 115,   TumCP↑, 1,   tyrosinase↓, 2,   Wnt↓, 38,   Wnt↑, 2,   Wnt/(β-catenin)↓, 9,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   ANGPT2↓, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 14,   AP-1↝, 1,   ARG1/2↑, 1,   ATPase↓, 1,   AXL↓, 3,   BACH1↓, 1,   CA↓, 3,   Ca+2↓, 1,   Ca+2↑, 28,   Ca+2↝, 3,   CAFs/TAFs↓, 2,   cal2↓, 1,   cal2↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 2,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 10,   E-cadherin↑, 45,   EM↑, 1,   EMT?, 1,   EMT↓, 72,   EMT↑, 1,   EMT↝, 1,   EpCAM↓, 3,   F-actin↓, 3,   FAK↓, 22,   p‑FAK↓, 4,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 3,   GIT1↓, 1,   GLI2↓, 4,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 1,   LAMs↓, 3,   LEF1↓, 1,   LRP1↓, 1,   MALAT1↓, 2,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 3,   MMP1↓, 8,   MMP13↓, 4,   MMP14↓, 1,   MMP16↓, 1,   MMP2↓, 115,   MMP2↝, 1,   MMP3↓, 11,   MMP7↓, 13,   MMP9↓, 146,   MMP9↑, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 42,   MMPs↝, 1,   MRGPRF↓, 1,   MTA1↓, 1,   MUC4↓, 2,   N-cadherin↓, 28,   NCAM↑, 1,   PAK1↓, 1,   pax↓, 1,   PDGF↓, 11,   Rac1↓, 3,   RECK↑, 2,   Rho↓, 5,   Rho↑, 1,   ROCK1↓, 5,   ROCK1↑, 2,   Slug↓, 10,   Smad1↓, 1,   Smad1↑, 1,   SMAD2↓, 2,   p‑SMAD2↓, 1,   SMAD3↓, 3,   p‑SMAD3↓, 1,   Snail?, 1,   Snail↓, 24,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 24,   TGF-β↑, 2,   TGF-β1↓, 3,   TIMP1↓, 2,   TIMP1↑, 12,   TIMP2↓, 3,   TIMP2↑, 14,   TIMP3↑, 1,   TSC1↑, 1,   TSP-1↑, 5,   TumCA↓, 2,   TumCI↓, 68,   TumCMig↓, 73,   TumCMig↑, 1,   TumMeta?, 1,   TumMeta↓, 72,   TumMeta↑, 5,   Twist↓, 26,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 29,   uPAR↓, 4,   UroPA↓, 1,   Vim?, 1,   Vim↓, 34,   Vim↑, 1,   Zeb1↓, 12,   Zeb1↑, 1,   ZEB2↓, 3,   α-SMA↓, 4,   α-tubulin↓, 2,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 47,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 169,   angioG↑, 5,   angioS↑, 1,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 14,   EGR1↑, 1,   Endoglin↓, 1,   Endoglin↑, 1,   eNOS↓, 4,   HIF-1↓, 11,   Hif1a↓, 141,   LOX1↓, 3,   NO↓, 8,   NO↑, 2,   NO↝, 1,   VCAM-1↓, 4,   VEGF↓, 412,   VEGF↑, 5,   VEGF↝, 2,   VEGFR1↓, 7,   VEGFR2/KDR/Flk1↓, 29,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 4,   CLDN1↓, 3,   CLDN1↑, 1,   CLDN2↓, 1,   CLDN2↑, 1,   CTR1↑, 2,   CX43/GJA1↓, 1,   EPR↑, 4,   EPR↝, 1,   GLUT1↓, 20,   GLUT1↑, 1,   GLUT3↑, 1,   IBI↑, 1,   KCNH2/hERG↓, 1,   MMP↓, 67,   MMP↑, 5,   MMP∅, 1,   MPT↑, 4,   NHE1↓, 2,   OCLN↑, 1,   TJ↑, 1,   TRPM7↓, 2,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↑, 2,   CD44↓, 14,   CD8+↑, 2,   COX1↓, 3,   COX2/PTGS2↓, 96,   COX2/PTGS2↑, 3,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 4,   CXCL16↓, 1,   CXCR2↓, 1,   CXCR4↓, 20,   CXCR4↑, 1,   DR4↑, 6,   FOXP3↓, 2,   GM-CSF↓, 2,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 12,   IFN-γ↓, 3,   IFN-γ↑, 3,   Igs↑, 1,   IL1↓, 10,   IL10↓, 8,   IL10↑, 3,   IL12↓, 4,   IL12↑, 1,   IL1α↓, 2,   IL1β↓, 13,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 7,   IL4↓, 2,   IL4↑, 1,   IL6↓, 52,   IL6↑, 1,   IL6↝, 1,   IL8↓, 16,   Imm↑, 10,   Imm↝, 3,   INF-γ↑, 1,   Inflam↓, 26,   LIF↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 6,   MCT1↓, 1,   MDSCs↓, 2,   MIP2↓, 2,   mPGES-1↓, 3,   MyD88↓, 1,   MyD88↑, 1,   NF-kB↓, 157,   NF-kB↑, 1,   NF-kB↝, 2,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 9,   NLRP3↓, 4,   NLRP3↑, 2,   p50↓, 1,   p65↓, 10,   p65↑, 1,   p‑p65↓, 4,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 11,   PGE2↓, 16,   PSA↓, 9,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 3,   Th2↑, 1,   TLR4↓, 8,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 39,   TNF-α↑, 4,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRAF1↓, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   Ach↓, 1,   AChE↑, 1,   SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AhR↑, 1,   AhR↓, 1,   AR↓, 18,   AR↝, 1,   CYP19↓, 2,   ER-α36↓, 2,   ER-α36↝, 1,   ER(estro)↓, 2,   Estro↝, 1,   FGF21↓, 2,   GR↑, 1,   PPARα↓, 3,   cl‑PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 9,   RANKL↓, 1,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   BioAv↓, 42,   BioAv↑, 48,   BioAv↝, 6,   BioEnh↑, 5,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 128,   ChemoSen⇅, 1,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1A2↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 4,   Dose↓, 1,   Dose↑, 9,   Dose↝, 33,   Dose∅, 7,   eff↓, 16,   eff↑, 54,   eff↝, 15,   eff∅, 1,   Half-Life↓, 13,   Half-Life↑, 3,   Half-Life↝, 8,   Half-Life∅, 2,   MDR1↓, 10,   MRP1/ABCC1↓, 6,   P-gp/ABCB1↓, 15,   P450↓, 4,   RadioS?, 1,   RadioS↑, 46,   selectivity↑, 50,   Synergy↑, 90,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 3,   ALAT↓, 5,   ALAT↑, 1,   ALAT↝, 1,   ALP↓, 4,   ALP↝, 1,   AR↓, 18,   AR↝, 1,   ascitic↓, 3,   AST↓, 4,   AST↑, 1,   AST↝, 1,   BloodF↓, 1,   BloodF↑, 1,   BRAF↓, 1,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA1↝, 1,   CEA↓, 1,   CRP↓, 3,   E6↓, 3,   E7↓, 3,   EGFR↓, 45,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 2,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 6,   HER2/EBBR2↓, 9,   hTERT/TERT↓, 14,   IL6↓, 52,   IL6↑, 1,   IL6↝, 1,   IRes↓, 1,   LDH↓, 2,   LDH↑, 2,   Maspin↑, 1,   Myc↓, 9,   NSE↓, 1,   PD-L1↓, 11,   PSA↓, 9,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   TP53↓, 1,   TP53↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 40,   AntiCan∅, 1,   antiNeop↑, 7,   AntiTum↑, 14,   cachexia↓, 2,   cardioP↑, 6,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 23,   chemoPv↑, 19,   ChemoSideEff↓, 7,   fatigue↓, 2,   hepatoP↑, 5,   Mucositis↓, 1,   neuroP↑, 7,   NP/CIPN↓, 1,   Obesity↓, 1,   ORR↑, 1,   OS↑, 19,   Pain↓, 1,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 4,   radioP↑, 9,   Remission↑, 1,   RenoP↑, 6,   Risk↓, 12,   Risk↑, 1,   Sleep↑, 1,   toxicity↓, 15,   toxicity↑, 3,   toxicity↝, 4,   toxicity∅, 1,   TumVol↓, 24,   TumW↓, 11,   Weight↓, 1,   Weight↑, 2,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 1080

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 2,   antiOx↓, 1,   antiOx↑, 64,   Catalase↓, 1,   Catalase↑, 36,   Fenton↓, 1,   GPx↓, 1,   GPx↑, 20,   GPx3↑, 1,   GPx4↑, 1,   GSH↑, 24,   GSR↑, 6,   GSTs↑, 9,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 18,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 24,   MDA↓, 22,   MPO↓, 4,   MPO↑, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 40,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 93,   ROS↑, 1,   mt-ROS?, 1,   SOD↑, 37,   SOD1↑, 2,   SOD2↑, 3,   TBARS↓, 2,   TOS↓, 1,   uricA↓, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   PDH↑, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 4,   5LO↝, 1,   ALAT↓, 15,   AMPK↓, 1,   AMPK↑, 6,   p‑AMPK↑, 1,   ATP↑, 2,   cytoP450↓, 1,   glucose↓, 5,   GlucoseCon↑, 3,   Glycolysis↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   H2S↑, 1,   HK1↑, 1,   LDL↓, 4,   lipidLev↓, 1,   NADPH↓, 2,   NADPH↑, 1,   PDKs↓, 1,   SIRT1↑, 8,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 9,   ASC?, 1,   ASC↓, 1,   BAD↓, 1,   BAX↓, 6,   Bax:Bcl2↓, 2,   Bcl-2↓, 1,   Bcl-2↑, 3,   Bcl-xL↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp3?, 1,   Casp3↓, 14,   cl‑Casp8↑, 1,   Casp9↓, 4,   Cyt‑c↓, 4,   Fas↓, 1,   Ferroptosis↓, 2,   IAP1↓, 1,   iNOS↓, 10,   iNOS↑, 2,   p38↓, 3,   p38↑, 1,   Pyro?, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 9,   Akt↑, 6,   p‑Akt↑, 2,   AKT1↑, 1,   CREB↑, 1,   EGFR↓, 1,   ERK↓, 2,   ERK↑, 1,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IKKα↑, 1,   IκB?, 1,   IκB↓, 1,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 2,   p‑LIMK1↑, 1,   MAPK↓, 8,   MAPK↑, 3,   mTOR↓, 4,   mTOR↑, 2,   P70S6K↓, 1,   PI3K↓, 8,   PI3K↑, 5,   PKA↑, 1,   PKCδ↓, 2,   PKCδ↑, 1,   PTEN↑, 1,   Sp1/3/4↓, 1,   Sp1/3/4↑, 1,   STAT↓, 1,   STAT3↓, 4,   STAT3↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   cMyc↓, 2,   HDAC↓, 1,   OCT4↓, 1,   other↓, 2,   other↑, 6,   other↝, 4,   SOX18↑, 1,   SOX9↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   ER Stress↓, 2,   GRP78/BiP↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,   HSP90↑, 1,   HSPs↑, 1,   PERK↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,   DNAdam↓, 3,   P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD45A↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↓, 1,   CD133↑, 1,   Diff↑, 2,   FGF↑, 2,   IGF-1↓, 1,   IGFBP3↑, 1,   MSCs↑, 1,   neuroG↑, 1,   TumCP↓, 3,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 5,   Ca+2↑, 4,   Ca+2↝, 1,   Cartilage↑, 2,   p‑Cofilin↑, 1,   COL1↑, 1,   COL2A1↑, 1,   COL3A1↓, 1,   FAK↑, 1,   ITGB1↑, 1,   p‑MLC2/MYL9↑, 1,   MMP13↓, 1,   MMP2↓, 3,   MMP2↑, 2,   MMP3↓, 1,   MMP9↓, 6,   MMP9↑, 3,   MMPs↑, 1,   MYPT1 / PPP1R12A↑, 1,   p‑MYPT1 / PPP1R12A↑, 1,   N-cadherin↑, 2,   PAI-1/SERPINE1↓, 1,   PDGF↑, 1,   Rac1↑, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↑, 1,   SLIT2↑, 1,   SMAD4↑, 1,   SMAD5↑, 1,   TGF-β↓, 3,   TGF-β↑, 3,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   uPA↓, 1,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   angioG↑, 15,   angioG↝, 1,   CD31/PECAM-1↓, 2,   CD31/PECAM-1↑, 2,   E-sel↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   eNOS↑, 1,   p‑eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 5,   Hif1a↑, 6,   Hif1a∅, 1,   NO↓, 14,   NO↑, 3,   VCAM-1↓, 6,   VEGF↓, 22,   VEGF↑, 32,   VEGFR2/KDR/Flk1↓, 1,   VEGFR2/KDR/Flk1↑, 1,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 9,   BBB↝, 1,   GLUT2↑, 1,   GLUT3↑, 3,   GLUT4↑, 3,   MMP↑, 6,   MUC19↓, 1,   MUC2↓, 1,   MUC5AC↓, 1,   OATPs↓, 1,   OCLN↓, 1,   TRPC1↓, 1,   VGCC↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 29,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 3,   ICAM-1↓, 5,   IFN-γ↓, 3,   IL1↓, 4,   IL1↑, 1,   IL10↓, 3,   IL10↑, 9,   IL12↓, 2,   IL13↓, 1,   IL17↓, 3,   IL18↓, 3,   IL1β↓, 20,   IL2↓, 3,   IL2↑, 1,   IL23↓, 1,   IL4↓, 6,   IL4↑, 1,   IL5↓, 3,   IL6↓, 31,   IL6↑, 1,   IL8↓, 4,   Imm↑, 5,   Imm⇅, 1,   Inflam?, 1,   Inflam↓, 89,   Inflam↑, 1,   IRF3↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 3,   MyD88↓, 2,   NF-kB↓, 43,   NF-kB↑, 1,   NLRP3↓, 9,   p65↓, 1,   PGE2↓, 13,   PGE2↑, 2,   RAGE↓, 1,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 5,   TLR4∅, 1,   TNF-α↓, 34,   TNF-α↑, 2,   Treg lymp↝, 1,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 1,   AChE↓, 12,   ADAM10↑, 1,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 8,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 4,   PSD95↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 2,   Aβ↓, 13,   Aβ42↓, 1,   BACE/β-secretase↓, 4,   tau↓, 3,   p‑tau↓, 8,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   CYP19↓, 1,   END↑, 1,   Estro↓, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 3,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 32,   BioAv↑, 24,   BioAv↝, 9,   BioEnh↑, 2,   CompStab↑, 2,   Dose↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 9,   eff↓, 1,   eff↑, 11,   eff↝, 1,   GSTA1↑, 2,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 9,   Half-Life∅, 3,   P-gp/ABCB1↓, 1,   P450↓, 2,   selectivity↑, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 15,   ALP↓, 5,   ascitic↓, 1,   AST↓, 18,   BMD↑, 2,   BP↓, 2,   p‑BRCA1↑, 1,   BUN↓, 1,   creat↓, 1,   CRP↓, 4,   EGFR↓, 1,   IL6↓, 31,   IL6↑, 1,   LDH↓, 7,   LDH↑, 1,   NOS2↓, 1,   RAGE↓, 1,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AirwayM↓, 1,   Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 16,   AntiArt↑, 7,   AntiCan↓, 1,   AntiCan↑, 8,   antiD↓, 1,   AntiDiabetic↑, 14,   AntiMyl↑, 1,   antiPs↑, 2,   AntiTum↑, 1,   cardioP↑, 32,   chemoP↑, 8,   chemoPv↑, 1,   cognitive↓, 1,   cognitive↑, 18,   diuretic↑, 1,   hepatoP↑, 31,   Learn↑, 2,   memory↑, 21,   motorD↑, 4,   Mucositis↓, 1,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 58,   Obesity↓, 9,   OS↑, 2,   Pain↓, 5,   QoL↑, 1,   radioP↑, 5,   RenoP↓, 1,   RenoP↑, 8,   Stroke↓, 6,   toxicity↓, 22,   toxicity↑, 2,   toxicity↝, 6,   toxicity∅, 9,   Weight↑, 1,   Wound Healing↓, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 3,   AntiViral↑, 10,   Bacteria↓, 16,   Bacteria↑, 1,   GutMicro↑, 13,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,  
Total Targets: 437

Scientific Paper Hit Count for: VEGF, Vascular endothelial growth factor
17 Thymoquinone
16 Apigenin (mainly Parsley)
15 Curcumin
14 Magnetic Fields
13 EGCG (Epigallocatechin Gallate)
12 Resveratrol
11 Betulinic acid
11 Sulforaphane (mainly Broccoli)
10 Quercetin
10 Garcinol
9 Baicalein
9 Berberine
9 Chrysin
8 Silver-NanoParticles
8 Propolis -bee glue
8 Fisetin
8 Kaempferol
7 Artemisinin
7 Boswellia (frankincense)
7 Silymarin (Milk Thistle) silibinin
6 Radiotherapy/Radiation
6 Fucoidan
6 Luteolin
6 Melatonin
5 Beta-Caryophyllene
5 Chlorogenic acid
5 Ellagic acid
5 Emodin
5 Formononetin
5 Gambogic Acid
5 Hydrogen Gas
5 Honokiol
4 Cisplatin
4 Ashwagandha(Withaferin A)
4 Bevacizumab (brand Avastin)
4 Caffeic acid
4 Cinnamon
4 Deguelin
4 D-limonene
4 Ferulic acid
4 Isoliquiritigenin
4 Juglone
4 Lycopene
4 Matrine
4 methylseleninic acid
4 Methylsulfonylmethane
4 Nimbolide
4 Phenethyl isothiocyanate
3 Alpha-Lipoic-Acid
3 Chemotherapy
3 Boron
3 Capsaicin
3 Carvacrol
3 Crocetin
3 Diindolylmethane
3 Eugenol
3 Flaxseed/Linseed
3 Ginkgolide B
3 iodine
3 phytic acid, Inositol hexakisphosphate
3 Licochalcone A
3 Magnolol
3 mebendazole
3 Naringin
3 Piperine
3 Selenite (Sodium)
2 Biochanin A
2 Thymol-Thymus vulgaris
2 Celecoxib
2 Celastrol
2 chaetocin
2 Cucurbitacin
2 Ursolic acid
2 Diclofenac
2 Gallic acid
2 Gemcitabine (Gemzar)
2 Genistein (soy isoflavone)
2 Ginger/6-Shogaol/Gingerol
2 Gossypol/AT-101
2 Proanthocyanidins
2 Hydroxycinnamic-acid
2 HydroxyTyrosol
2 Hyperoside
2 MCT, metronomic chemo
2 lambertianic acid
2 Licorice
2 SDG/lignans
2 Phenylbutyrate
2 Piperlongumine
2 Rosmarinic acid
2 Shikonin
2 Vitamin C (Ascorbic Acid)
1 1,8-Cineole
1 Annona atemoya Seed Extract
1 Auranofin
1 Astragalus
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 Andrographis
1 Isovitexin
1 Ascorbyl Palmitate
1 Astaxanthin
1 Aloe anthraquinones
1 beta-glucans
1 immunotherapy
1 Baicalin
1 Berbamine
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Centella asiatica / Gotu kola → asiaticoside
1 chitosan
1 Coenzyme Q10
1 Vitamin E
1 Carvone
1 Dandelion Root
1 Ginkgo biloba-EGb 761
1 Docetaxel
1 Bortezomib
1 olaparib/LYNPARZA
1 Paclitaxel/Taxol
1 Ginkgetin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Grapeseed extract
1 Hibiscus sabdariffa
1 Hops (Humulus lupulus)
1 Indole-3-carbinol
1 Inositol
1 Extracorporeal Shock Wave Therapy
1 isoflavones
1 isoorientin
1 itraconazole
1 Lactoferrin/Talactoferrin
1 Methyl Jasmonate
1 vp16, etoposide
1 Moringa oleifera
1 tamoxifen
1 Mistletoe/Viscum album Extracts
1 Mushroom Shiitake, AHCC
1 Myricetin
1 Niclosamide (Niclocide)
1 Neem
1 Oleuropein
1 Marjoram (Origanum majorana)
1 Plumbagin
1 VitK3,menadione
1 Psoralidin
1 Pterostilbene
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Sanguinarine
1 Salvia miltiorrhiza
1 Theobromine
1 Aflavin-3,3′-digallate
1 Urolithin
1 Vitamin D3
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:334  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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