Casp3 Cancer Research Results

Casp3, CPP32, Cysteinyl aspartate specific proteinase-3: Click to Expand ⟱
Source:
Type:
Also known as CP32.
Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a common key protein in the apoptosis and pyroptosis pathways, and when activated, the expression level of tumor suppressor gene Gasdermin E (GSDME) determines the mechanism of tumor cell death.
As a key protein of apoptosis, caspase-3 can also cleave GSDME and induce pyroptosis. Loss of caspase activity is an important cause of tumor progression.
Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to shrink tumors. Crucial for apoptotic function are executioner caspases, most notably caspase-3, that proteolyze a variety of proteins, inducing cell death. Paradoxically, overexpression of procaspase-3 (PC-3), the low-activity zymogen precursor to caspase-3, has been reported in a variety of cancer types. Until recently, this counterintuitive overexpression of a pro-apoptotic protein in cancer has been puzzling. Recent studies suggest subapoptotic caspase-3 activity may promote oncogenic transformation, a possible explanation for the enigmatic overexpression of PC-3. Herein, the overexpression of PC-3 in cancer and its mechanistic basis is reviewed; collectively, the data suggest the potential for exploitation of PC-3 overexpression with PC-3 activators as a targeted anticancer strategy.
Caspase 3 is the main effector caspase and has a key role in apoptosis. In many types of cancer, including breast, lung, and colon cancer, caspase-3 expression is reduced or absent.
On the other hand, some studies have shown that high levels of caspase-3 expression can be associated with a better prognosis in certain types of cancer, such as breast cancer. This suggests that caspase-3 may play a role in the elimination of cancer cells, and that therapies aimed at activating caspase-3 may be effective in treating certain types of cancer.
Procaspase-3 is a apoptotic marker protein.
Prognostic significance:
• High Cas3 expression: Associated with good prognosis and increased sensitivity to chemotherapy in breast, gastric, lung, and pancreatic cancers.
• Low Cas3 expression: Linked to poor prognosis and increased risk of recurrence in colorectal, hepatocellular carcinoma, ovarian, and prostate cancers.
Scientific Papers found: Click to Expand⟱
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
9- CUR,    Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and Vivo
- vitro+vivo, MG, U87MG - vitro+vivo, MG, T98G
HH↓, Shh↓, Gli1↓, cycD1/CCND1↓, Bcl-2↓, FOXM1↓, Bax:Bcl2↑, TumCP↓, TumCMig↓, Apoptosis↑, TumVol↑, TumCCA↑, Casp3↑, OS↑,
167- CUR,    Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria
- in-vitro, Pca, PC3
MAPK↑, JNK↑, Casp3↑, Casp8↑, Casp9↑, AIF↑, GSH↓, eff↓, Apoptosis↑, DNAdam↑,
6234- CUSP9,    In Vitro and Clinical Compassionate Use Experiences with the Drug-Repurposing Approach CUSP9v3 in Glioblastoma
- Human, GBM, NA
TumCP↓, Apoptosis↑, TumCMig↓, tumCV↓, TumCG↓, cl‑Casp3↑,
1878- DCA,  5-FU,    Synergistic Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer
- in-vitro, CRC, LS174T - in-vitro, CRC, LoVo - in-vitro, CRC, SW-620 - in-vitro, CRC, HT-29
tumCV↓, eff↑, PDKs↓, lactateProd↓, Glycolysis↓, mitResp↑, TumCCA↑, Bcl-2↓, BAX↑, Casp3↑,
1874- DCA,    Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, MDAH-2774
Apoptosis↑, MPO↓, iNOS↓, Hif1a↓, SOD↑, Casp3↑,
4901- DCA,  Sal,    Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer
- Review, NSCLC, NA
Glycolysis↓, OXPHOS↑, PDKs↓, ROS↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, RadioS↑, TumAuto↑, mTOR↓, LC3s↓, p62↑, TumCG↓, OS↑, toxicity↝, ChemoSen↑, eff↑, eff↑, Ferritin↓, CSCs↓, EMT↓, ROS↑, Cyt‑c↑, Casp3↑, ER Stress↑, selectivity↑, eff↑, TumCG↓,
1444- Deg,    Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer
- in-vitro, GC, MKN-28
Casp9↑, Casp3↑, Hif1a↓, VEGF↓, TumCCA↑, TumCG↓, DNAdam↑, p‑Akt↓,
4455- DFE,    Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest
- in-vitro, BC, MCF-7 - in-vitro, Nor, 3T3
TumCCA↑, P53↑, BAX↑, Casp3↑, MMP↓, Fas↑, FasL↑, Bcl-2↓, Apoptosis↑, TumCP↓, TUNEL↑, eff↑, selectivity↑,
1854- dietFMD,    How Far Are We from Prescribing Fasting as Anticancer Medicine?
- Review, Var, NA
ChemoSideEff↓, ChemoSen↑, IGF-1↓, IGFBP1↑, adiP↑, glyC↓, E-cadherin↑, MMPs↓, Casp3↑, ROS↑, ATP↓, AMPK↑, mTOR↓, ROS↑, Glycolysis↓, NADPH↓, OXPHOS↝, eff↑, eff↑, *RAS↓, *MAPK↓, *PI3K↓, *Akt↓, eff↑, ROS↑, Akt↑, Casp3↑,
1860- dietFMD,  Chemo,    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
- in-vitro, BC, SUM159 - in-vitro, BC, 4T1
PI3K↑, Akt↑, mTOR↑, CDK4↑, CDK6↑, hyperG↓, TumCG↓, TumVol↓, Casp3↑, BG↓, eff↑, eff∅, PKA↓, KLF5↓, p‑GSK‐3β↑, Nanog↓, OCT4↓, KLF2↓, eff↑, ROS↑, BIM↑, ASK1↑, PI3K↑, Akt↑, mTOR↑, CDK1↓, CDK4↑, CDK6↑, eff↑,
2270- dietMet,    Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice
- in-vivo, Var, NA
Weight↓, TumVol↓, P21↑, p27↑, *adiP↑, *glucose↓, *IGF-1↓, *FGF21↑, *OS↑, Ki-67↓, Casp3↑, cycD1/CCND1↓,
6290- DL,    Induction of apoptosis by d-limonene is mediated by a caspase-dependent mitochondrial death pathway in human leukemia cells
- in-vitro, AML, K562 - in-vitro, AML, HL-60
BAX↑, Cyt‑c↑, Casp9↑, cl‑Casp3↑, mtDam↑, Apoptosis↑,
6269- DL,    Induction of apoptosis by D-limonene is mediated by inactivation of Akt in LS174T human colon cancer cells
- in-vitro, CRC, LS174T
tumCV↓, Apoptosis↑, Casp3↑, Casp9↑, cl‑PARP↑, BAX↑, Cyt‑c↑, Bcl-2↓, PI3K↓, Akt↓,
6273- DL,    D-Limonene Exhibits Antiproliferative Activity Against Human Colorectal Adenocarcinoma (Caco-2) Cells via Regulation of Inflammatory and Apoptotic Pathways
- in-vitro, Colon, Caco-2 - in-vitro, Nor, HEK293 - in-vitro, Colon, HCT116
ROS↑, antiOx↓, GSH↓, Casp3↑, BAX↑, P53↑, LDH↑, TNF-α↑, IL1β↑, MMP2↓, MMP9↓, Ki-67↓, Bcl-2↓, selectivity↑,
6274- DL,    Protective Effect of D-Limonene against Oxidative Stress-Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway
- in-vitro, Nor, NA
*antiOx↑, *ROS↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *Bax:Bcl2↑, *p‑p38↓,
6277- DL,  docx,    d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis
- in-vitro, Pca, DU145 - in-vitro, Nor, PZ-HPV-7
ChemoSen↑, selectivity↑, ROS↑, GSH↓, Casp↑, eff↓, TumCP↓, cl‑Casp9↑, cl‑Casp3↑, P21↑, BAD↑, cl‑PARP↑, Bcl-xL↓, P53↑, mtDam↑, *toxicity↓,
6288- DL,    From Citrus to Clinic: Limonene’s Journey Through Preclinical Research, Clinical Trials, and Formulation Innovations
- Review, Var, NA - Review, AD, NA
other↑, DDS↑, *antiOx↑, *Inflam↓, *AntiDiabetic↑, *neuroP↑, *Imm↑, *Wound Healing↑, *other↑, *BioAv↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *DNAdam↓, *AntiDiabetic↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, *AChE↓, *BChE↓, *Aβ↓, *ROS↓, *toxicity?,
6280- DL,    Biochemical significance of limonene and its metabolites: future prospects for designing and developing highly potent anticancer drugs
- Review, Var, NA
BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, TGF-β↑, Bcl-2↓, VEGF↓, AntiTum↑, *Inflam↓, *Bacteria↓,
6344- DRE,    Dandelion: Purported Benefits, Side Effects & More
- Review, Var, NA
*other↝, *hepatoP↑, *ALAT↓, *MDA↓, *TNF-α↓, *IL6↓, *antiOx↑, *Inflam↓, *proCasp3↓, Casp3↑, tumCV↓, TNF-α↑, IL1↑,
6350- DRE,    Tracking Evidences of Dandelion for the Treatment of Cancer: From Chemical Composition, Bioactivity, Signaling Pathways in Cancer Cells to Perspective Study
- Review, Var, NA
AntiCan↑, *Bacteria↓, *Inflam↓, *antiOx↑, TumCCA↑, Apoptosis↑, MOMP↑, Cyt‑c↑, APAF1↑, Casp9↑, Casp3↑, MMP↓, Bcl-2↓, TumCMig↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, MMP2↓, MMP9↓, TumAuto↑, mTOR↓, 4E-BP1↓, Glycolysis↓, angioG↓,
6319- DRE,    Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells
- in-vitro, AML, MV411 - in-vitro, AML, HL-60
Apoptosis↑, TumAuto↑, *toxicity↓, selectivity↑, Casp8↑, MMP↓, *Inflam↓, *antiOx↑, *AntiCan↑, DNAdam↑, cl‑Casp3↑, tumCV↓, ROS↑,
6320- DRE,    Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic cancer cells
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
Apoptosis↑, MMP↓, TumAuto↑, selectivity↑, eff↑, Casp8↑, Casp3↑, cl‑BID↑, mtDam↑, ROS↑,
6353- DRE,  Cisplatin,    Insights Into Protective Mechanisms of Dandelion Leaf Extract Against Cisplatin-Induced Nephrotoxicity in Rats: Role of Inhibitory Effect on Inflammatory and Apoptotic Pathways
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *NF-kB↓, *Cyt‑c↓, *DNAdam↓, *GSH↑, *SOD↑, *Albumin↝, *creat↓, *BUN↓, *RenoP↑, *lipid-P↓, *TNF-α↓, *Casp3↓, *Casp9↓, *chemoP↑,
6351- DRE,  Rad,    Differential effect of Taraxacum officinale L. (dandelion) root extract on hepatic and testicular tissues of rats exposed to ionizing radiation
- in-vivo, Nor, NA
*radioP↑, *ROS↓, *MDA↓, *GSH↑, *SOD↑, *IL1β↓, *TNF-α↓, *Casp3↓, *eff↑,
6360- DRE,    Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma
- in-vitro, ESCC, KYSE450 - in-vitro, ESCC, Eca109
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, survivin↓, Bax:Bcl2↑, Casp3↑, Casp9↑, MMP2↓, MMP9↓, VEGF↓, EMT↓, eff↑, DNAdam↑, p‑STAT3↑, ChemoSen↑,
6363- DRE,    Therapeutic Potential of Dandelion (Taraxacum officinale) Root Extract in Colon Cancer: A Comprehensive Review
- in-vitro, CRC, NA
Apoptosis↑, *Inflam↓, TLR4↓, NF-kB↓, *GutMicro↑, mtDam↑, *ROS↓, Casp1↑, TNF-α↑, Bcl-2↓, PARP↓, MMP↓, Cyt‑c↓, Casp3↑, TumVol↓, COX2↓, iNOS↓, ROS↑, selectivity↑, TumCMig↓, TumCI↓, ER Stress↑, PERK↑, eIF2α↑, ATF4↑, CHOP↑, TumCCA↑, cycD1/CCND1↓, P21↓, P53↑, BioAv↝, Half-Life↝,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, P53↑, TumCCA↑, IL6↓, COX2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,
1606- EA,    Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells
- in-vitro, Colon, HCT15
TumCP↓, cycD1/CCND1↓, Apoptosis↑, PI3K↓, Akt↓, ROS↑, Casp3↑, Cyt‑c↑, Bcl-2↓, TumCCA↑, Dose∅, ALP↓, LDH↓, PCNA↓, P53↑, Bax:Bcl2↑,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, PANC1
HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2↓, Hif1a↓, VEGF↓, VEGFR2↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,
20- EGCG,    Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer
- in-vivo, Liver, NA - in-vivo, Tong, NA
HH↓, Gli1↓, Smo↓, TNF-α↓, COX2↓, *antiOx↑, Hif1a↓, NF-kB↓, VEGF↓, STAT3↓, Bcl-2↓, P53↑, Akt↓, p‑Akt↓, p‑mTOR↓, EGFR↓, AP-1↓, BAX↑, ROS↑, Casp3↑, Apoptosis↑, NRF2↑, *H2O2↓, *NO↓, *SOD↑, *Catalase↑, *GPx↑, *ROS↓,
22- EGCG,    Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
- in-vitro, PC, CD133+ - in-vitro, PC, CD44+ - in-vitro, PC, CD24+ - in-vitro, PC, ESA+
HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, survivin↓, Casp3↑, Casp7↑, CSCs↓, Nanog↓, cMyc↓, OCT4↓, EMT↓, Snail↓, Slug↓, Zeb1↓, TumCMig↓, TumCI↓, eff↑,
989- EGCG,  Citrate,    In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity
- in-vitro, HCC, NA - in-vivo, NA, NA
PFK↓, Glycolysis↓, lactateProd↓, GlucoseCon↓, TumCP↓, TumCCA↑, Casp3↑, cl‑PARP↑, Apoptosis↑, Casp8↑, Casp9↑, Cyt‑c↝, MMP↓, BAD↑, GLUT2↓, PKM2∅,
668- EGCG,    The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment
- Review, BC, MCF-7 - Review, BC, MDA-MB-231
HER2/EBBR2↓, EGFR↓, mtDam↑, ROS↑, PI3K/Akt↓, P53↑, P21↑, Casp3↑, Casp9↑, BAX↑, PTEN↑, Bcl-2↓, hTERT/TERT↓, STAT3↓, TumCCA↑, Hif1a↓,
689- EGCG,    EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down regulation of NF-κB and MMP-9
- vitro+vivo, Bladder, SW780
Casp8↑, Casp9↑, Casp3↑, BAX↑, PARP↑, TumVol↓, NF-kB↓, MMP9↓,
681- EGCG,    Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models
- vitro+vivo, BC, NA
Casp3↑, Casp8↑, Casp9↑, TumAuto↑, Beclin-1↝, ATG5↝, GlucoseCon↓, lactateProd↓, ATP↝, HK2↓, LDHA↓, Hif1a↓, GLUT1↓, TumVol↓, VEGF↓,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2↓, angioG↓,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
3203- EGCG,    (-)- Epigallocatechin-3-gallate induces GRP78 accumulation in the ER and shifts mesothelioma constitutive UPR into proapoptotic ER stress
- NA, MM, NA
ROS↑, Ca+2↝, GRP78/BiP↑, ATF4↑, XBP-1↑, CHOP↑, Casp3↑, Casp8↑, *GRP78/BiP↓, *UPR↓, UPR↑,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, eff↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
3206- EGCG,    Insights on the involvement of (-)-epigallocatechin gallate in ER stress-mediated apoptosis in age-related macular degeneration
- Review, AMD, NA
*Ca+2↓, *ROS↓, *Apoptosis↓, *GRP78/BiP↓, *CHOP↓, *PERK↓, *IRE1↓, *p‑PARP↓, *Casp3↓, *Casp12↓, *ER Stress↓, *UPR↓,
3208- EGCG,    Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α
- in-vitro, Colon, HT29 - in-vitro, Nor, 3T3
TumCD↓, ER Stress↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, IRE1↑, Apoptosis↑, Casp3↑, Casp7↑, Wnt↓, β-catenin/ZEB1↓, *toxicity∅, UPR↑,
1976- EGCG,    Epigallocatechin-3-gallate exhibits anti-tumor effect by perturbing redox homeostasis, modulating the release of pro-inflammatory mediators and decreasing the invasiveness of glioblastoma cells
- in-vitro, GBM, U87MG
ROS↑, MMP↓, Casp3↑, Cyt‑c↑, Trx1↓, Ceru↓, IL6↓, IL8↓, MCP1↓, RANTES?, uPA↝, ROS↑,
1303- EGCG,    (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation
- in-vitro, EC, NA
TumCP↓, ER-α36↓, cycD1/CCND1↓, ERK↑, Jun↓, BAX↑, Bcl-2↓, cl‑Casp3↑, ROS↑, p38↑,
1516- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*Dose∅, Half-Life∅, BioAv∅, BBB↑, toxicity∅, eff↓, Apoptosis↑, Casp3↑, Cyt‑c↑, cl‑PARP↑, DNMTs↓, Telomerase↓, angioG↓, Hif1a↓, NF-kB↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, IGF-1↓, H3↓, HDAC1↓, *LDH↓, *ROS↓,
5225- EMD,    Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3
- vitro+vivo, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
STAT3↓, Akt↓, cSrc↓, JAK1↓, JAK2↓, SHP1↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCP↓, Casp3↑, cl‑PARP↑, ChemoSen↑, XIAP↓,
1245- EMD,    Emodin Exhibits Strong Cytotoxic Effect in Cervical Cancer Cells by Activating Intrinsic Pathway of Apoptosis
- in-vitro, Cerv, HeLa
TumCG↓, TumCP↓, Apoptosis↑, ROS↑, Casp3↑, Casp9↑, MMP↓, DNAdam↑, GSH↓,
1332- EMD,    Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway
- in-vivo, Nor, HepaRG
*tumCV↓, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↑, *Bax:Bcl2↑, *Casp3↑, *Casp8↑, *Casp9↑, *cl‑PARP↑, *TumCCA↑, *P21↑, *cycE/CCNE↑, *cycA1/CCNA1↓, *CDK2↓,

Showing Research Papers: 351 to 400 of 805
Prev Page 8 of 17 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 805

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

NA↓, 1,  

Redox & Oxidative Stress ⓘ

antiOx↓, 2,   Ceru↓, 1,   GSH↓, 5,   GSTs↑, 1,   HO-1↓, 2,   HO-2↓, 1,   hyperG↓, 1,   MAD↓, 1,   MPO↓, 1,   NRF2↑, 1,   NRF2↝, 1,   OXPHOS↑, 1,   OXPHOS↝, 1,   ROS↑, 24,   ROS↝, 1,   SOD↑, 1,   TBARS↑, 1,   Trx1↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,   KLF5↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 2,   ATP↓, 1,   ATP↝, 1,   mitResp↑, 1,   MMP↓, 11,   MMP↑, 1,   mtDam↑, 5,   OCR↓, 1,   XIAP↓, 5,  

Core Metabolism/Glycolysis ⓘ

adiP↑, 1,   AMPK↑, 2,   cMyc↓, 2,   ECAR↝, 1,   GlucoseCon↓, 4,   GLUT2↓, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 6,   HK2↓, 1,   lactateProd↓, 6,   LDH↓, 2,   LDH↑, 1,   LDHA↓, 1,   NADPH↓, 1,   PDH↝, 1,   PDK1?, 2,   PDKs↓, 2,   PFK↓, 1,   PI3K/Akt↓, 1,   PKM2∅, 1,   cl‑PPARα↓, 1,   SIRT1↓, 2,  

Cell Death ⓘ

Akt↓, 6,   Akt↑, 4,   Akt↝, 1,   p‑Akt↓, 6,   APAF1↑, 1,   Apoptosis↑, 22,   Apoptosis↝, 1,   ASK1↑, 1,   BAD↑, 3,   Bak↑, 3,   BAX↑, 16,   BAX⇅, 1,   BAX↝, 1,   Bax:Bcl2↑, 5,   Bcl-2↓, 19,   Bcl-2↝, 1,   Bcl-xL↓, 5,   Bcl-xL↝, 1,   cl‑BID↑, 1,   BIM↑, 1,   Casp↑, 1,   Casp1↑, 1,   Casp3↑, 40,   Casp3↝, 1,   cl‑Casp3↑, 5,   Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 9,   Casp9↑, 15,   cl‑Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 12,   Cyt‑c↝, 2,   Diablo↑, 2,   DR4↑, 1,   DR5↑, 1,   Fas↑, 2,   FasL↑, 1,   HEY1↓, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 1,   iNOS↓, 3,   JNK↓, 1,   JNK↑, 1,   JNK↝, 1,   MAPK↓, 2,   MAPK↑, 1,   Mcl-1↓, 3,   MDM2↓, 1,   MDM2↑, 1,   MOMP↑, 1,   Myc↓, 2,   NOXA↑, 1,   p27↑, 2,   p38↑, 1,   PUMA↑, 1,   survivin↓, 6,   Telomerase↓, 4,   TumCD↓, 1,   TUNEL↑, 1,  

Kinase & Signal Transduction ⓘ

cSrc↓, 1,   HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

H3↓, 1,   HATs↓, 1,   other↑, 1,   pRB↑, 1,   tumCV↓, 6,  

Protein Folding & ER Stress ⓘ

CHOP↑, 4,   eIF2α↑, 2,   ER Stress↑, 5,   GRP78/BiP↑, 3,   IRE1↑, 1,   PERK↑, 2,   UPR↑, 3,   XBP-1↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   ATG5↝, 1,   Beclin-1↑, 1,   Beclin-1↝, 1,   LC3B↑, 1,   LC3II↑, 2,   LC3s↓, 1,   p62↑, 1,   TumAuto↑, 6,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNAdam↑, 5,   DNMTs↓, 3,   p16↑, 1,   P53↑, 12,   P53↝, 1,   PARP↓, 1,   PARP↑, 3,   cl‑PARP↑, 8,   PCNA↓, 3,   SIRT6↑, 1,   TP53↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 3,   CDK2↑, 1,   CDK4↓, 1,   CDK4↑, 2,   Cyc↝, 1,   cycD1/CCND1↓, 10,   cycD1/CCND1↝, 1,   cycE/CCNE↓, 2,   P21↓, 1,   P21↑, 5,   P21↝, 1,   p‑RB1↓, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State ⓘ

4E-BP1↓, 1,   CDK8↓, 1,   CIP2A↓, 1,   CSCs↓, 2,   EMT↓, 4,   ERK↑, 1,   p‑ERK↓, 1,   FOXM1↓, 1,   FOXO↑, 1,   Gli↓, 1,   Gli1↓, 4,   p‑GSK‐3β↑, 1,   HDAC↓, 2,   HDAC1↓, 1,   HH↓, 4,   IGF-1↓, 2,   IGF-1R↑, 1,   IGFBP1↑, 1,   Jun↓, 1,   mTOR↓, 3,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 1,   Nanog↓, 2,   NOTCH↓, 3,   NOTCH1↓, 1,   NOTCH3↓, 2,   OCT4↓, 2,   PI3K↓, 4,   PI3K↑, 2,   PI3K↝, 1,   PTCH1↓, 1,   PTCH2↓, 1,   PTEN↑, 4,   PTEN↝, 1,   Shh↓, 3,   SHP1↑, 1,   Smo↓, 2,   STAT3↓, 4,   p‑STAT3↓, 2,   p‑STAT3↑, 1,   TumCG↓, 8,   Wnt↓, 2,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AP-1↓, 2,   AP-1↝, 1,   Ca+2↝, 2,   E-cadherin↑, 3,   ER-α36↓, 1,   FAK↓, 1,   p‑FAK↓, 1,   GLI2↓, 2,   Ki-67↓, 3,   KLF2↓, 1,   MMP2↓, 7,   MMP2↝, 1,   MMP9↓, 10,   MMPs↓, 3,   PDGF↓, 1,   PKA↓, 1,   PKCδ↓, 2,   Slug↓, 1,   SMAD3↓, 1,   Snail↓, 4,   TGF-β↓, 1,   TGF-β↑, 2,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 5,   TumCMig↓, 6,   TumCP↓, 14,   TumMeta↓, 1,   Twist↓, 1,   uPA↓, 2,   uPA↝, 1,   Vim↓, 1,   Zeb1↓, 1,   Zeb1↑, 1,   β-catenin/ZEB1↓, 3,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 6,   ATF4↑, 4,   EGFR↓, 4,   EGFR↝, 1,   Endoglin↑, 1,   Hif1a↓, 11,   VEGF↓, 10,   VEGF↝, 1,   VEGFR2↓, 2,  

Barriers & Transport ⓘ

BBB↑, 1,   GLUT1↓, 2,   NHE1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 6,   COX2↝, 1,   IL1↑, 1,   IL1β↑, 1,   IL6↓, 3,   IL6↝, 1,   IL8↓, 2,   Inflam↓, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 1,   MCP1↓, 1,   NF-kB↓, 7,   NF-kB↝, 1,   p‑NF-kB↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   PSA↝, 1,   RANTES?, 1,   TLR4↓, 1,   TNF-α↓, 3,   TNF-α↑, 3,   TNF-α↝, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↝, 1,   CDK6↓, 5,   CDK6↑, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   BioAv∅, 1,   ChemoSen↑, 7,   DDS↑, 1,   Dose↝, 1,   Dose∅, 2,   eff↓, 3,   eff↑, 17,   eff∅, 1,   Half-Life↝, 1,   Half-Life∅, 1,   RadioS↑, 4,   selectivity↑, 9,  

Clinical Biomarkers ⓘ

ALP↓, 1,   AR↝, 1,   BG↓, 1,   EGFR↓, 4,   EGFR↝, 1,   Ferritin↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 3,   IL6↝, 1,   Ki-67↓, 3,   LDH↓, 2,   LDH↑, 1,   Myc↓, 2,   PD-L1↓, 1,   PSA↝, 1,   TP53↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   chemoP↑, 1,   ChemoSideEff↓, 2,   OS↑, 2,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 5,   TumVol↑, 1,   Weight↓, 1,  
Total Targets: 325

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 9,   Catalase↑, 2,   GPx↑, 1,   GSH↑, 3,   H2O2↓, 1,   lipid-P↓, 1,   MDA↓, 2,   MPO↓, 1,   NRF2↑, 1,   RNS↓, 1,   ROS↓, 11,   ROS↑, 1,   SOD↑, 4,   SOD1↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

adiP↑, 1,   ALAT↓, 1,   BUN↓, 1,   FGF21↑, 1,   glucose↓, 2,   LDH↓, 1,   LDL↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↓, 3,   BAX↓, 1,   Bax:Bcl2↑, 2,   Casp12↓, 1,   Casp3↓, 4,   Casp3↑, 1,   proCasp3↓, 1,   Casp8↑, 1,   Casp9↓, 2,   Casp9↑, 1,   Cyt‑c↓, 2,   Fas↑, 1,   iNOS↓, 1,   MAPK↓, 1,   p‑p38↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 1,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 2,   IRE1↓, 1,   PERK↓, 1,   UPR↓, 2,  

DNA Damage & Repair ⓘ

DNAdam↓, 2,   P53↓, 1,   P53↑, 1,   p‑PARP↓, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   cycE/CCNE↑, 1,   E2Fs↑, 1,   P21↑, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,   IGF-1R↓, 1,   PI3K↓, 1,   RAS↓, 1,  

Migration ⓘ

AP-1↓, 1,   Ca+2?, 1,   Ca+2↓, 1,   MMP2↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,   PDGFR-BB↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 1,   IL6↓, 2,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 9,   JAK↓, 1,   NF-kB↓, 3,   TNF-α↓, 4,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BChE↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 2,   BioAv↝, 1,   Dose↝, 1,   Dose∅, 1,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   Albumin↝, 1,   creat↓, 1,   GutMicro↑, 1,   IL6↓, 2,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 2,   cardioP↑, 2,   chemoP↑, 1,   hepatoP↓, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 3,   OS↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity?, 1,   toxicity↓, 2,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 2,  
Total Targets: 112

Scientific Paper Hit Count for: Casp3, CPP32, Cysteinyl aspartate specific proteinase-3
35 Silver-NanoParticles
33 Quercetin
32 Curcumin
29 Thymoquinone
26 Apigenin (mainly Parsley)
22 Sulforaphane (mainly Broccoli)
21 Baicalein
21 Berberine
17 EGCG (Epigallocatechin Gallate)
17 Shikonin
16 Chrysin
15 Propolis -bee glue
15 Fisetin
14 Artemisinin
14 Allicin (mainly Garlic)
14 Capsaicin
14 Honokiol
13 Cisplatin
13 Magnetic Fields
13 Ashwagandha(Withaferin A)
12 Betulinic acid
12 Boron
12 Silymarin (Milk Thistle) silibinin
11 Eugenol
11 Emodin
10 Luteolin
10 Resveratrol
9 Alpha-Lipoic-Acid
9 Radiotherapy/Radiation
9 Carvacrol
9 Graviola
9 Magnolol
9 Phenylbutyrate
8 D-limonene
8 Citric Acid
8 Dandelion Root
8 Garcinol
8 Lycopene
7 doxorubicin
7 Gambogic Acid
7 Juglone
7 Phenethyl isothiocyanate
7 Piperlongumine
7 Rosmarinic acid
6 5-fluorouracil
6 Beta-Caryophyllene
6 Bufalin/Huachansu
6 Chlorogenic acid
6 Nimbolide
6 Selenite (Sodium)
6 Vitamin K2
5 Boswellia (frankincense)
5 α-Bisabolol / Chamomile oil
5 chitosan
5 Crocetin
5 Ursolic acid
5 salinomycin
5 Ellagic acid
5 Magnetic Field Rotating
5 Plumbagin
5 Aflavin-3,3′-digallate
4 3-bromopyruvate
4 Melatonin
4 Anethole/trans-Anethole
4 Astaxanthin
4 Bromelain
4 borneol
4 Caffeic acid
4 Chemotherapy
4 Carvone
4 Cucurbitacin
4 Dichloroacetate
4 Paclitaxel
4 Geraniol
4 Naringin
4 Propyl gallate
4 Piperine
4 VitK3,menadione
4 Urolithin
3 Auranofin
3 Berbamine
3 Photodynamic Therapy
3 Biochanin A
3 Brucea javanica
3 Carnosic acid
3 Thymol-Thymus vulgaris
3 Celastrol
3 Docetaxel
3 Hydroxycinnamic-acid
3 Laetrile B17 Amygdalin
3 Psoralidin
3 Pterostilbene
3 α-Santalol/Sandalwood oil
3 Vitamin C (Ascorbic Acid)
2 1,8-Cineole
2 Coenzyme Q10
2 Astragalus
2 SonoDynamic Therapy UltraSound
2 Gemcitabine (Gemzar)
2 tamoxifen
2 Andrographis
2 Fennel Oil/Foeniculum vulgare
2 Metformin
2 Aloe anthraquinones
2 brusatol
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Cat’s Claw
2 Cinnamon
2 Copper and Cu NanoParticles
2 diet FMD Fasting Mimicking Diet
2 Electrical Pulses
2 Eurycomanone
2 Ferulic acid
2 Gallic acid
2 HydroxyCitric Acid
2 HydroxyTyrosol
2 Huperzine A/Huperzia serrata
2 Magnesium
2 Oleuropein
2 Parthenolide
2 Selenium
2 Selenium NanoParticles
2 Vitamin D3
1 5-Aminolevulinic acid
1 entinostat
1 Camptothecin
1 Resiquimod
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 2-DeoxyGlucose
1 Ascorbyl Palmitate
1 Trastuzumab
1 almonertinib
1 epirubicin
1 temozolomide
1 Bacopa monnieri
1 Butyrate
1 Sorafenib (brand name Nexavar)
1 immunotherapy
1 Oxaliplatin
1 CUSP9
1 Deguelin
1 Date Fruit Extract
1 diet Methionine-Restricted Diet
1 Fucoidan
1 carboplatin
1 Galloflavin
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Hydrogen Gas
1 Orlistat
1 Hyperthermia
1 itraconazole
1 lambertianic acid
1 Linalool
1 Lutein
1 Iron
1 Myricetin
1 nelfinavir/Viracept
1 sericin
1 isoflavones
1 Hyperoside
1 Sanguinarine
1 Scoulerine
1 polyethylene glycol
1 Folic Acid, Vit B9
1 Osimertinib
1 Adagrasib
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 triptolide
1 Turmerones
1 Vitamin B1/Thiamine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:42  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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