Casp3 Cancer Research Results

Casp3, CPP32, Cysteinyl aspartate specific proteinase-3: Click to Expand ⟱
Source:
Type:
Also known as CP32.
Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a common key protein in the apoptosis and pyroptosis pathways, and when activated, the expression level of tumor suppressor gene Gasdermin E (GSDME) determines the mechanism of tumor cell death.
As a key protein of apoptosis, caspase-3 can also cleave GSDME and induce pyroptosis. Loss of caspase activity is an important cause of tumor progression.
Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to shrink tumors. Crucial for apoptotic function are executioner caspases, most notably caspase-3, that proteolyze a variety of proteins, inducing cell death. Paradoxically, overexpression of procaspase-3 (PC-3), the low-activity zymogen precursor to caspase-3, has been reported in a variety of cancer types. Until recently, this counterintuitive overexpression of a pro-apoptotic protein in cancer has been puzzling. Recent studies suggest subapoptotic caspase-3 activity may promote oncogenic transformation, a possible explanation for the enigmatic overexpression of PC-3. Herein, the overexpression of PC-3 in cancer and its mechanistic basis is reviewed; collectively, the data suggest the potential for exploitation of PC-3 overexpression with PC-3 activators as a targeted anticancer strategy.
Caspase 3 is the main effector caspase and has a key role in apoptosis. In many types of cancer, including breast, lung, and colon cancer, caspase-3 expression is reduced or absent.
On the other hand, some studies have shown that high levels of caspase-3 expression can be associated with a better prognosis in certain types of cancer, such as breast cancer. This suggests that caspase-3 may play a role in the elimination of cancer cells, and that therapies aimed at activating caspase-3 may be effective in treating certain types of cancer.
Procaspase-3 is a apoptotic marker protein.
Prognostic significance:
• High Cas3 expression: Associated with good prognosis and increased sensitivity to chemotherapy in breast, gastric, lung, and pancreatic cancers.
• Low Cas3 expression: Linked to poor prognosis and increased risk of recurrence in colorectal, hepatocellular carcinoma, ovarian, and prostate cancers.
Scientific Papers found: Click to Expand⟱
6631- Cic,    Chicoric acid is a potent anti-atherosclerotic ingredient by anti-oxidant action and anti-inflammation capacity.
- in-vitro, Nor, NA
*MMP↑, *BAX↓, *DNAdam↓, *Casp3↓, *NF-kB↓, *antiOx↑, *Inflam↓,
6623- Cic,  MTX,    Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling
- in-vivo, Nor, NA
*antiOx↑, *hepatoP↑, *ROS↓, *lipid-P↓, *TAC↑, *NRF2↑, *HO-1↑, *NQO1↑, *PPARγ↑, *Inflam↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *Casp3↓,
6165- Cin,  doxoR,    Cinnamaldehyde potentiates cytotoxic and apoptogenic effects of doxorubicin in prostate cancer cell line
- in-vitro, Pca, PC3
ChemoSen↑, ROS↑, Casp3↑, Casp7↑,
8998- Citicoline,  Rad,    The impact of citicoline on brain mitochondrial dysfunction induced in rats after head irradiation
- in-vivo, Nor, NA
*Dose↝, *ROS↓, *compI↑, *compIII↑, *ATP↑, *Ca+2↓, *Iron↓, *Casp3↓, *glucose↝, *ACE/ACE1↑, *AChE↓,
8993- Citicoline,    Citicoline protects against lead-induced oxidative injury in neuronal PC12 cells
- in-vitro, Nor, PC12
*Apoptosis↓, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GSH↑, *BAX↓, *Bcl-2↑, *Casp3↓, *neuroP↑, *ROS↓,
2315- Citrate,  immuno,    Why and how citrate may sensitize malignant tumors to immunotherapy
- Review, Var, NA
Bcl-2↓, Mcl-1↓, survivin↓, Casp3↑, Casp9↑, Ferroptosis↑, lipid-P↑, Ca+2↓, Akt↓, mTOR↓, Hif1a↓, MCU↓, ATP↓, ROS↑, eff↑,
1593- Citrate,    Citrate Induces Apoptotic Cell Death: A Promising Way to Treat Gastric Carcinoma?
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901
PFK↓, Glycolysis↓, tumCV↓, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, ATP↓, ChemoSen↑, Mcl-1↓, glucoNG↑, FBPase↑, OXPHOS↓, TCA↓, β-oxidation↓, HK2↓, PDH↓, ROS↑,
1587- Citrate,    ATP citrate lyase: A central metabolic enzyme in cancer
- Review, Var, NA
ACLY↓, other↓, PFK1↓, ATP↓, PFK2↓, Mcl-1↓, Casp3↑, Casp2↑, Casp9↑, IGF-1R↓, PI3K↓, Akt↓, p‑Akt↓, p‑ERK↓, PTEN↑, Snail↓, E-cadherin↑, ChemoSen↑,
1585- Citrate,    Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S - in-vitro, Nor, HEK293
Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,
1580- Citrate,    Citrate activates autophagic death of prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway
- in-vitro, Pca, PC3 - in-vivo, PC, NA - in-vitro, Pca, LNCaP - in-vitro, Pca, WPMY-1
Apoptosis↑, Ca+2↓, Akt↓, mTOR↓, selectivity↑, TumCP↓, cl‑Casp3↑, cl‑PARP↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, ATG5↑, ATG7↑, Beclin-1/ATG6↑, TumAuto↑, CaMKII ↓,
1578- Citrate,    Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update
- Review, Var, NA
TCA↑, FASN↑, Glycolysis↓, glucoNG↑, PFK1↓, PFK2↓, FBPase↑, TumCP↓, eff↑, ACLY↓, Dose↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, Bcl-xL↓, Mcl-1↓, IGF-1R↓, PI3K↓, Akt↓, mTOR↓, PTEN↑, ChemoSen↑, Dose?,
1576- Citrate,    Targeting citrate as a novel therapeutic strategy in cancer treatment
- Review, Var, NA
TCA↓, T-Cell↝, Glycolysis↓, PKM2↓, PFK2?, SDH↓, PDH↓, β-oxidation↓, CPT1A↓, FASN↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, cl‑PARP↑, Hif1a↓, GLUT1↓, angioG↓, Ca+2↓, ROS↓, eff↓, Dose↓, Synergy↑, Mcl-1↓, HK2↓, IGF-1R↓, PTEN↑, citrate↓, Dose∅, ChemoSen↑, eff↑, eff↑, Synergy↑,
4772- CoQ10,    The anti-tumor activities of coenzyme Q0 through ROS-mediated autophagic cell death in human triple-negative breast cells
- in-vitro, BC, MDA-MB-468 - in-vitro, BC, MDA-MB-231
TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, LC3II↑, eff↓, TumCG↓, Bax:Bcl2↑, Beclin-1/ATG6↑, TumAuto↑, ROS↑,
6306- Cro,    Crocetin induces apoptosis of BGC-823 human gastric cancer cells
- in-vitro, GC, BGC-823
TumCP↓, MMP↓, Casp3↑, Cyt‑c↑,
6334- Cro,  Eug,  Rad,    Crocin and eugenol enhance radiosensitivity in oral squamous cell carcinoma cells via apoptotic pathways and cell cycle regulation. Type of study: in vitro
- in-vitro, OS, NA
tumCV↓, RadioS↑, TumCCA↑, BAX↑, Casp3↑, Bcl-2↓, cycA1/CCNA1↓, CycB/CCNB1↓,
3624- Cro,    Crocus Sativus L. (Saffron) in Alzheimer's Disease Treatment: Bioactive Effects on Cognitive Impairment
- Review, AD, NA
*AChE↓, *memory↑, *cognitive↑, *MDA↑, *Thiols↑, *GPx↑, *antiOx↑, *ROS↓, *Casp3↓, *neuroP↑, *SOD↑, *Ach↑, *ChAT↑, *BBB↑, *Aβ↓, *tau↓, *cognitive↑, *Inflam↓,
3630- Cro,    Crocin Improves Cognitive Behavior in Rats with Alzheimer's Disease by Regulating Endoplasmic Reticulum Stress and Apoptosis
- in-vivo, AD, NA
*memory↑, *Bcl-2↑, *BAX↓, *Casp3↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *Dose↝,
3631- Cro,    Investigation of the neuroprotective effects of crocin via antioxidant activities in HT22 cells and in mice with Alzheimer's disease
- in-vitro, AD, HT22 - in-vivo, AD, NA
*ROS↓, *Ca+2↓, *BAX↓, *BAD↓, *Casp3↓, *cognitive↑, *memory↑, *Aβ↓, *GPx↑, *SOD↑, *ChAT↑, *Ach↑, *AChE↓, *ROS↓, *p‑Akt↑, *p‑mTOR↑, *neuroP↑,
6521- CRV,    L-carvone induces p53, caspase 3 mediated apoptosis and inhibits the migration of breast cancer cell lines
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, Apoptosis↑, TumCCA↑, DNAdam↑, ROS↑, GSH↑, P53↑, BAD↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑,
6527- CRV,    Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events
- in-vivo, Melanoma, NA
AntiTum↑, P450↓, GSR↑, GSTs↑, GSH↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, p53 Wildtype↓, chemoPv↑, Apoptosis↑,
6520- CRV,    Health Benefits and Pharmacological Properties of Carvone
- Review, Nor, NA
*Bacteria↓, *AntiFungal↑, *antiOx↑, *Inflam↓, AntiCan↑, *AntiDiabetic↑, *Obesity↓, TumCCA↑, *AntiArt↑, Imm↑, *P450↓, *GSR↑, GSTs↑, GSH↑, BAX↑, Casp3↑, TumCP↓, TumCMig↓, Apoptosis↑,
6525- CRV,    D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4)
- in-vitro, AML, NA
tumCV↓, ROS↑, antiOx↓, MMP↓, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, *neuroP↑, AntiCan↑, *AntiArt↑, TBARS↑, SOD↓, GSH↓, Catalase↓,
7416- CS,  Poly,    Phenolic-Rich Extracts from Artichoke By-Products Promote Apoptosis in Human Colorectal Cancer Cell Lines
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HT29
tumCV↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, Apoptosis↑, other↝, eff↑,
7424- CS,  CGA,    Antioxidative and apoptotic properties of polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells
- in-vitro, Nor, NA - in-vitro, Liver, HepG2
*ROS↓, *GSH↑, *MDA↓, tumCV↓, Apoptosis↑, Casp3↑,
7425- CS,    Artichoke as a melanoma growth inhibitor
- in-vitro, Melanoma, NA
AntiCan↑, tumCV↓, PCNA↓, Casp3↑, P21↑, p27/CDKN1B↑, CDK4↓, survivin↓, TumCP↓, Apoptosis↑,
6176- Cu,    Copper Oxide Nanoparticles Induced Mitochondria Mediated Apoptosis in Human Hepatocarcinoma Cells
- in-vitro, Liver, HepG2
ROS↑, P53↑, MMP↓, Bax:Bcl2↑, Apoptosis↑, *Bacteria↓, MDA↑, GSH↓, eff↓, Casp3↑,
1572- Cu,    Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy
- Review, Var, NA
eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP/DDIT3↑, Apoptosis↑, selectivity↑, Synergy↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,
6189- Cuc,    Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells
- in-vitro, Lung, A549
TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, Cyt‑c↑, STAT3↓, Casp3↑, Casp9↑, MMP↓,
6191- Cuc,    Growth inhibitory effect of Cucurbitacin E on breast cancer cells
- in-vitro, BC, MDA-MB-231
TumCG↓, TumCCA↑, Apoptosis↑, Casp3↑, P21↑, p27/CDKN1B↑, ChemoSen↑, STAT3↓,
6195- Cuc,    Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
- Review, Var, NA
TumCG↓, Apoptosis↑, TumCCA↑, TumMeta↓, angioG↓, chemoPv↑, BioAv↓, Half-Life↝, cycD1/CCND1↓, cycE/CCNE↓, Casp3↑, cl‑PARP↑, JNK↑, Akt↓, ERK↓, survivin↓, XIAP↓, Bcl-2↓, Mcl-1↓, ROS↑, NRF2↓, FAK↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, *NF-kB↓, TLR4↝, NLRP3↑, Pyro↑, GSH↓,
6202- Cuc,    Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms
- Review, Var, NA
*Inflam↓, *antiOx↑, *hepatoP↑, AntiTum↑, AntiCan↑, *chemoPv↑, *AntiDiabetic↑, *Imm↑, Hif1a↓, P-gp/ABCB1↓, mTORC1↓, ERK↓, Akt↓, Casp3↑, Casp7↑, ATP↓, RadioS↑, ChemoSen↑,
3580- CUR,    Curcumin Acts as Post-protective Effects on Rat Hippocampal Synaptosomes in a Neuronal Model of Aluminum-Induced Toxicity
- in-vivo, AD, NA
*ROS↓, *Cyt‑c↓, *Casp3↓, *neuroP↑,
4652- CUR,    Anticancer effect of curcumin on breast cancer and stem cells
- Review, BC, NA
TumCP↓, TumMeta↓, TumCCA↑, Apoptosis↑, CSCs↓, NF-kB↓, Telomerase↓, Cyt‑c↑, Casp9↑, Casp3↑, E-cadherin↑,
475- CUR,    Curcumin induces apoptotic cell death in human pancreatic cancer cells via the miR-340/XIAP signaling pathway
- in-vitro, PC, PANC1
Apoptosis↑, cl‑Casp3↑, miR-340↑, cl‑PARP↑, XIAP↓,
472- CUR,    Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis
- vitro+vivo, Ovarian, SKOV3 - vitro+vivo, Ovarian, A2780S
TumCP↓, Apoptosis↑, PCNA↓, miR-320a↓, BAX↑, cl‑Casp3↑, circ‑PLEKHM3↑, SMG1↑,
468- CUR,  5-FU,    Gut microbiota enhances the chemosensitivity of hepatocellular carcinoma to 5-fluorouracil in vivo by increasing curcumin bioavailability
- vitro+vivo, Liver, HepG2 - vitro+vivo, Liver, 402 - vitro+vivo, Liver, Bel7
Apoptosis↑, TumCCA↑, PI3k/Akt/mTOR↓, p‑PI3K↓, Bacteria↑, cl‑Casp3↑,
462- CUR,    Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stress
- in-vitro, Pca, PC3
Bcl-2↓, MMP↓, cl‑Casp3↑, BAX↑, BIM↑, p‑PARP↑, PUMA↑, p‑P53↑, ROS↑, p‑ERK↑, p‑eIF2α↑, CHOP/DDIT3↑, ATF4↑,
461- CUR,    Curcumin inhibits prostate cancer progression by regulating the miR-30a-5p/PCLAF axis
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, miR-30a-5p↑, PCLAF↓, Bcl-2↓, Casp3↓, BAX↑, cl‑Casp3↑,
458- CUR,    Curcumin suppresses gastric cancer by inhibiting gastrin‐mediated acid secretion
- vitro+vivo, GC, SGC-7901
Casp3↑, Apoptosis↑, TumCP↓,
457- CUR,    Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
TumCP↓, Apoptosis↑, TumAuto↑, P53↑, PI3K↓, P21↑, p‑Akt↓, p‑mTOR↓, Bcl-2↓, Bcl-xL↓, LC3I↓, BAX↑, Beclin-1/ATG6↑, cl‑Casp3↑, cl‑PARP↑, LC3II↑, ATG3↑, ATG5↑,
479- CUR,    Curcumin Has Anti-Proliferative and Pro-Apoptotic Effects on Tongue Cancer in vitro: A Study with Bioinformatics Analysis and in vitro Experiments
- in-vitro, Tong, CAL27
TumCP↓, TumCMig↓, Apoptosis↑, TumCCA↑, Bcl-2↓, BAX↑, cl‑Casp3↑,
477- CUR,    Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells
- in-vitro, Cerv, SiHa
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, CycB/CCNB1↓, CDC25↓, ROS↑, p62↑, LC3‑Ⅱ/LC3‑Ⅰ↑, cl‑Casp3↑, cl‑PARP↑, P53↑, P21↑,
425- CUR,    Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells
- in-vitro, BC, T47D - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
CDC25↓, cDC2↓, P21↑, p‑Akt↓, p‑mTOR↓, Bcl-2↓, BAX↑, Casp3↑,
452- CUR,    Curcumin downregulates the PI3K-AKT-mTOR pathway and inhibits growth and progression in head and neck cancer cells
- vitro+vivo, HNSCC, SCC9 - vitro+vivo, HNSCC, FaDu - vitro+vivo, HNSCC, HaCaT
TumCCA↑, PI3k/Akt/mTOR↓, Casp3↑, EGFR↓, EGF↑, PRKCG↑, p‑Akt↓, p‑mTOR↓, RPS6KA1↓, EIF4E↓, proCasp3↓,
447- CUR,  OXA,    Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-β/Smad2/3 signaling pathway
- vitro+vivo, CRC, HCT116
p‑p65↓, Bcl-2↓, Casp3↑, EMT↓, p‑SMAD2↓, p‑SMAD3↓, N-cadherin↓, TGF-β↓, E-cadherin↑, TumVol↓, TumCMig↓,
444- CUR,  Cisplatin,    LncRNA KCNQ1OT1 is a key factor in the reversal effect of curcumin on cisplatin resistance in the colorectal cancer cells
- vitro+vivo, CRC, HCT8
TumVol↓, Apoptosis↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑Casp3↑, cl‑PARP1↑, miR-497↑, KCNQ1OT1↓,
137- CUR,    Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling
- in-vitro, Pca, DU145
NOTCH1↓, cycD1/CCND1↓, CDK2↓, P21↑, p27/CDKN1B↑, P53↑, Bcl-2↓, Casp3↑, Casp9↑, TumCCA↑, TumCP↓, Apoptosis↑,
132- CUR,    Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells
- in-vitro, Pca, PC3
TumCCA↑, ROS↑, TumAuto↑, UPR↑, ER Stress↑, Casp3↑, Casp9↑, Casp12↑, PARP↑, other↝, GRP78/BiP↑, PDI↑, eIF2α↑, other↝,
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2/PTGS2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
9- CUR,    Curcumin Suppresses Malignant Glioma Cells Growth and Induces Apoptosis by Inhibition of SHH/GLI1 Signaling Pathway in Vitro and Vivo
- vitro+vivo, MG, U87MG - vitro+vivo, MG, T98G
HH↓, Shh↓, Gli1↓, cycD1/CCND1↓, Bcl-2↓, FOXM1↓, Bax:Bcl2↑, TumCP↓, TumCMig↓, Apoptosis↑, TumVol↑, TumCCA↑, Casp3↑, OS↑,

Showing Research Papers: 351 to 400 of 1195
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1195

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 3,   NA↑, 6,   NA⇅, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 7,   antiOx↑, 16,   antiOx⇅, 1,   ARE↓, 1,   Catalase↓, 17,   Catalase↑, 12,   Ceru↓, 1,   Copper↑, 1,   ENOX2↓, 1,   Fenton↑, 4,   frataxin↑, 1,   GCLM↓, 1,   GPx↓, 8,   GPx↑, 9,   GPx4↓, 11,   GSH↓, 82,   GSH↑, 16,   mt-GSH↓, 1,   GSH/GSSG↓, 9,   GSR↓, 3,   GSR↑, 5,   GSS↑, 1,   GSSG↓, 1,   GSSG↑, 1,   GSTs↓, 4,   GSTs↑, 5,   H2O2↓, 1,   H2O2↑, 15,   i-H2O2↑, 1,   mt-H2O2↑, 1,   HO-1↓, 13,   HO-1↑, 22,   HO-1↝, 1,   HO-2↓, 1,   hyperG↓, 1,   Iron↓, 1,   Iron↑, 5,   Iron↝, 1,   i-Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 11,   lipid-P↑, 22,   lipid-P↝, 1,   MDA↓, 8,   MDA↑, 20,   MPO↓, 4,   NADH↓, 1,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 3,   NQO1↑, 5,   Nrf1↑, 1,   NRF2↓, 29,   NRF2↑, 32,   NRF2⇅, 1,   NRF2↝, 1,   NRF2∅, 1,   p‑NRF2↓, 1,   p‑NRF2↑, 1,   OSI↑, 2,   Prx↓, 1,   Prx4↑, 1,   PrxII↓, 1,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 5,   ROS↓, 48,   ROS↑, 523,   ROS⇅, 14,   ROS↝, 2,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 5,   mt-ROS↑, 17,   RPM↑, 1,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 27,   SOD↑, 14,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 6,   SOD2↑, 8,   TAC↓, 2,   TAC↑, 2,   TBARS↑, 3,   Thiols↓, 3,   Thiols↝, 1,   TKT↓, 1,   TOS↑, 2,   Trx↓, 3,   Trx1↓, 2,   Trx1↑, 1,   ox-Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 12,   TrxR1↓, 7,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 3,   FTH1↓, 2,   IronCh↑, 4,   NCOA4↑, 1,   STEAP3↓, 1,   Tf↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 4,   CDC2↓, 9,   CDC2↑, 1,   CDC25↓, 23,   CDC25↑, 1,   p‑CDC25↑, 1,   compI↓, 3,   compII↓, 1,   compIII↓, 2,   compIV↓, 1,   compV↓, 1,   compV↓, 1,   EGF↓, 8,   EGF↑, 1,   ETC↓, 9,   ETC↝, 1,   HSP60/HSPD1↑, 1,   MCU↓, 1,   MFN2↓, 1,   MFN2↑, 1,   mitResp↓, 6,   mitResp↑, 1,   MKK7↓, 1,   mtDam↓, 1,   mtDam↑, 56,   OCR↓, 11,   OCR↑, 2,   OXPHOS↓, 7,   OXPHOS↑, 2,   OXPHOS↝, 1,   mt-OXPHOS↓, 4,   PDH↓, 3,   PDH↑, 3,   PDH↝, 1,   p‑PDH↓, 1,   PINK1↑, 4,   SDH↓, 4,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 6,   5LO↓, 4,   ACC↑, 5,   p‑ACC↑, 1,   Acetyl-CoA↓, 1,   ACLY↓, 5,   ACSL4↑, 2,   adiP↑, 1,   ALAT↓, 6,   ALAT↑, 1,   ALAT↝, 1,   ALDOA↓, 2,   AMP↑, 2,   AMPK↓, 3,   AMPK↑, 39,   p‑AMPK↑, 3,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 39,   ATP↝, 1,   e-ATP↑, 1,   CAIX/CA9↓, 4,   CAIX/CA9↑, 1,   i-Cer↑, 1,   citrate↓, 1,   CPT1A↓, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 4,   FAO↑, 1,   FASN↓, 8,   FASN↑, 2,   FBI-1↓, 1,   FBPase↑, 2,   FFA/NEFA↓, 1,   GALNT10↓, 1,   GAPDH↓, 2,   GLS↓, 1,   glucoNG↓, 1,   glucoNG↑, 2,   glucose↓, 1,   GlucoseCon↓, 24,   GlutaM↓, 1,   GlutMet↓, 2,   glyC↓, 1,   Glycolysis↓, 55,   GSK‐3β↓, 18,   GSK‐3β↑, 8,   p‑GSK‐3β↓, 9,   p‑GSK‐3β↑, 1,   Histones↑, 1,   HK1↓, 2,   HK2↓, 33,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   IDO1↓, 1,   lactateProd↓, 26,   lactateProd↑, 1,   LDHA↓, 13,   LDL↓, 2,   lipidLev↓, 1,   MCT4↓, 1,   NAD↓, 1,   NAD↝, 1,   NADPH↓, 5,   NADPH↑, 2,   O-Glc↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 10,   PDKs↓, 3,   PFK↓, 4,   PFK1↓, 2,   PFK2?, 1,   PFK2↓, 2,   PFKFB4?, 1,   PFKP↓, 1,   PGK1↓, 1,   PKM2↓, 19,   PKM2∅, 1,   PLA2↓, 1,   PPP↓, 2,   Pyruv↓, 1,   Pyruv↑, 1,   p‑S6↓, 1,   SIRT1↓, 12,   SIRT1↑, 7,   SREBP1/SREBF1↓, 3,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 6,   TCA↑, 2,   TS↓, 2,   TumCM/A↓, 1,   Warburg↓, 9,   β-oxidation↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 27,   APAF1↑, 19,   Apoptosis?, 4,   Apoptosis↓, 11,   Apoptosis↑, 587,   Apoptosis↝, 1,   mt-Apoptosis↑, 7,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 4,   BAD?, 1,   BAD↓, 5,   BAD↑, 32,   p‑BAD↓, 1,   Bak↓, 1,   Bak↑, 23,   BAX?, 1,   BAX↓, 9,   BAX↑, 410,   BAX⇅, 1,   BAX↝, 3,   BAX∅, 1,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 85,   Bcl-2↓, 421,   Bcl-2↑, 13,   Bcl-2↝, 3,   Bcl-2∅, 2,   cl‑Bcl-2↓, 1,   Bcl-xL↓, 84,   Bcl-xL↑, 4,   Bcl-xL↝, 2,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 18,   p‑BID↓, 1,   cl‑BID↑, 4,   BIM↓, 1,   BIM↑, 14,   BNIP3?, 1,   BNIP3↑, 3,   BNIP3↝, 1,   BOK↑, 2,   Casp↓, 1,   Casp↑, 28,   Casp1↓, 2,   Casp1↑, 2,   Casp10↓, 1,   Casp10↑, 3,   Casp12?, 1,   Casp12↑, 11,   Casp12↝, 1,   cl‑Casp12↑, 1,   Casp2↑, 5,   Casp3?, 4,   Casp3↓, 15,   Casp3↑, 833,   Casp3↝, 4,   Casp3∅, 2,   cl‑Casp3↓, 3,   cl‑Casp3↑, 204,   cl‑Casp3⇅, 1,   cl‑Casp3∅, 1,   proCasp3↓, 8,   proCasp3↑, 9,   pro‑Casp3↓, 1,   pro‑Casp3↑, 2,   pro‑Casp3↝, 1,   CASP4↑, 3,   Casp6↓, 1,   Casp6↑, 6,   Casp7?, 1,   Casp7↓, 1,   Casp7↑, 88,   cl‑Casp7↑, 11,   Casp8↓, 3,   Casp8↑, 144,   Casp8↝, 1,   Casp8∅, 3,   cl‑Casp8↑, 27,   proCasp8↓, 2,   proCasp8↑, 4,   pro‑Casp8↑, 1,   Casp9?, 2,   Casp9↓, 4,   Casp9↑, 380,   Casp9↝, 1,   Casp9∅, 1,   cl‑Casp9↓, 2,   cl‑Casp9↑, 64,   proCasp9↓, 4,   proCasp9↑, 5,   pro‑Casp9↑, 1,   CellShr↑, 1,   cFLIP↓, 16,   Cupro↑, 1,   Cyt‑c↓, 5,   Cyt‑c↑, 280,   Cyt‑c↝, 4,   Cyt‑c?, 1,   cl‑Cyt‑c↑, 1,   Diablo↑, 12,   DIDO1/DIO-1↑, 1,   DR5↑, 48,   Endon↑, 2,   FADD↑, 14,   Fap1↓, 2,   Fas↓, 3,   Fas↑, 45,   FasL↑, 28,   Ferroptosis↓, 1,   Ferroptosis↑, 15,   GranB/GZMB↝, 1,   GRP58↓, 1,   GSDME↑, 2,   cl‑GSDME↑, 1,   GSDME-N↑, 2,   HEY1↓, 2,   IAP1↓, 15,   IAP2/BIRC3↓, 6,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 2,   iNOS↓, 26,   iNOS↑, 1,   Mcl-1?, 1,   Mcl-1↓, 61,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 17,   MDM2↑, 2,   p‑MDM2↓, 2,   MLKL↑, 3,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 10,   NAIP↓, 2,   Necroptosis↑, 8,   necrosis↑, 6,   NOXA↑, 7,   p38↓, 7,   p38↑, 45,   p‑p38↓, 5,   p‑p38↑, 11,   Paraptosis↑, 1,   PDCD4↑, 1,   Perforin↝, 1,   PUMA↑, 12,   PUMA↝, 1,   Pyro↑, 9,   RIP3↓, 1,   RIP3↑, 5,   p‑RIP3↑, 3,   survivin↓, 107,   survivin↑, 1,   survivin↝, 2,   TNFR 1↑, 3,   TRAIL↑, 11,   TRAIL⇅, 1,   TRAILR↑, 3,   TumCD↓, 5,   TumCD↑, 48,   TumCD∅, 1,   TUNEL↑, 2,   XIAP↓, 54,   XIAP↑, 1,   YAP/TEAD↓, 4,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 226,   Akt↑, 14,   Akt↝, 1,   p‑Akt↓, 87,   AKT1↓, 5,   Akt2↓, 2,   AMPKα↑, 2,   BRAF↓, 2,   BRAF↝, 1,   CaMKII ↓, 3,   CIP2A↓, 2,   CK2↓, 4,   cMET↓, 4,   p‑cMET↑, 2,   p‑CREB↓, 2,   CREB2↓, 1,   cSrc↓, 6,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 49,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 3,   ERK↓, 78,   ERK↑, 17,   ERK↝, 1,   p‑ERK↓, 30,   p‑ERK↑, 8,   e-ERK↑, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 19,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 3,   Hippo↑, 1,   HRAS↓, 1,   IGF-1R↓, 8,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 9,   IKKα↑, 2,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 1,   IκB↑, 3,   p‑IκB↓, 3,   JAK↓, 4,   JAK1?, 1,   JAK1↓, 11,   JAK1↑, 2,   p‑JAK1↓, 2,   JAK2↓, 21,   p‑JAK2↓, 5,   JNK↓, 9,   JNK↑, 55,   JNK↝, 1,   p‑JNK↓, 4,   p‑JNK↑, 12,   cl‑JNK↑, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 47,   MAPK↑, 27,   MAPK↝, 3,   p‑MAPK↓, 3,   p‑MAPK↑, 3,   MARK4↓, 1,   MEK↓, 11,   p‑MEK↓, 4,   p‑MEK↑, 1,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   Mst1↑, 1,   mTOR↓, 111,   mTOR↑, 5,   mTOR↝, 2,   p‑mTOR↓, 27,   mTORC2↓, 4,   NIK↓, 1,   p70S6↓, 2,   P70S6K↓, 9,   p‑P70S6K↓, 2,   P90RSK↓, 1,   PDE3B↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 151,   PI3K↑, 3,   PI3K↝, 1,   p‑PI3K↓, 21,   PI3K/Akt↓, 5,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 4,   PI3k/Akt/mTOR↝, 1,   PIAS-3↑, 1,   PIK3CA↓, 1,   PKA↓, 3,   p‑PKA↓, 1,   PKCδ↓, 12,   p‑PKCδ↓, 1,   cl‑PKCδ↑, 1,   PP2A↑, 1,   PRAS40↑, 1,   PRKCG↑, 1,   PTEN↓, 4,   PTEN↑, 38,   PTEN↝, 2,   p‑PTEN↓, 2,   Raf↓, 7,   c-Raf↓, 1,   RAS↓, 12,   RAS↑, 1,   Rictor↓, 1,   RIP1↓, 2,   RIP1↑, 3,   RPS6KA1↓, 1,   p‑RSK↓, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,   S6K↓, 1,   p‑S6K↓, 2,   SHP1↓, 1,   SHP1↑, 5,   Sp1/3/4↓, 13,   Src↓, 5,   Src↑, 1,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 2,   STAT3↓, 97,   STAT3↑, 5,   p‑STAT3↓, 27,   p‑STAT3↑, 2,   STAT5↓, 3,   p‑STAT5↓, 1,   STAT6↓, 3,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 2,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   AntiThr↑, 1,   ATF1↓, 1,   ATF2↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 24,   ATF4↝, 1,   ATFs↑, 1,   ChrMod↑, 1,   ChrMod↝, 1,   cJun↓, 7,   cJun↑, 5,   p‑cJun↑, 2,   cMyc↓, 59,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 12,   DNMT1↑, 1,   DNMT3A↓, 4,   DNMTs↓, 9,   EZH2↓, 2,   FOXM1↓, 8,   FOXO↑, 2,   FOXO1↓, 2,   FOXO1↑, 4,   FOXO3↓, 7,   FOXO3↑, 9,   FOXO3↝, 1,   p‑FOXO3↓, 2,   FOXO4↑, 2,   GATA3↑, 1,   H3↓, 5,   H3↑, 2,   ac‑H3↑, 3,   H4↓, 1,   H4↑, 2,   ac‑H4↑, 2,   HATs↓, 7,   HATs↑, 2,   HDAC↓, 33,   HDAC1↓, 7,   HDAC10↑, 1,   HDAC2↓, 5,   HDAC3↓, 4,   HDAC8↓, 3,   HES1↓, 2,   HMTs↓, 2,   HOXB-AS1↓, 1,   KCNQ1OT1↓, 1,   KLF2↓, 1,   KLF5↓, 1,   miR-106b↓, 1,   miR-107↑, 1,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 4,   miR-17↓, 2,   miR-195↑, 1,   miR-200b↑, 1,   miR-21↓, 10,   miR-21↑, 1,   miR-22↑, 1,   miR-221↓, 1,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-25-5p↑, 1,   miR-27a-3p↓, 2,   miR-27a-3p↑, 1,   miR-29b↓, 1,   miR-30a-5p↑, 1,   miR-320a↓, 1,   miR-340↓, 1,   miR-340↑, 1,   miR-34a↓, 2,   miR-34a↑, 5,   miR-34b-5p↑, 1,   miR-384↑, 2,   miR-422a↑, 1,   miR-497↑, 1,   miR-590-3p↑, 1,   Myc↓, 6,   MYCN↓, 1,   n-MYC↓, 1,   NR1D2↓, 1,   OCT4↓, 17,   OCT4↑, 1,   other?, 1,   other↓, 5,   other↑, 10,   other↝, 13,   PhotoS↑, 2,   SALL4↓, 1,   sonoS↑, 2,   SOX2↓, 10,   SOX4↓, 1,   SOX4↑, 2,   SOX9?, 1,   SOX9↓, 1,   SUV39H↓, 3,   TCF-4↓, 2,   TET3↑, 1,   tumCV?, 3,   tumCV↓, 196,   tumCV↑, 1,   tumCV∅, 1,   ZBTB10↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 6,   cl‑ATF6↑, 1,   c-ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 57,   cl‑CHOP/DDIT3↑, 1,   CRT↑, 1,   CUL1↝, 1,   CUL5↝, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 14,   p‑eIF2α↓, 1,   p‑eIF2α↑, 13,   ER Stress↓, 5,   ER Stress↑, 94,   ER Stress↝, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 34,   GRP78/BiP↝, 1,   GRP94↑, 4,   HSF1↓, 1,   HSP27↓, 10,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 10,   HSP70/HSPA5↑, 4,   HSP70/HSPA5⇅, 1,   HSP70/HSPA5↝, 1,   HSP72↓, 1,   HSP90↓, 16,   HSP90↑, 3,   HSPs↓, 1,   IRE1↑, 9,   p‑IRE1↑, 1,   PDI↑, 1,   PERK↑, 17,   p‑PERK↑, 3,   SERPINH1/HSP47↓, 1,   UPR↑, 16,   XBP-1↓, 2,   XBP-1↑, 8,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 4,   ATG5↑, 19,   ATG5↝, 1,   ATG7↑, 5,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 34,   Beclin-1/ATG6↝, 1,   CTSB↓, 2,   CTSD↓, 2,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 9,   LC3A↑, 3,   LC3B↑, 6,   LC3B-II↑, 5,   LC3I↓, 1,   LC3I↑, 2,   LC3II↓, 3,   LC3II↑, 29,   LC3s↓, 1,   LC3s↑, 3,   MitoP↑, 2,   p62↓, 13,   p62↑, 10,   PARK2↑, 4,   RUBCN↓, 1,   SESN2↑, 2,   TumAuto↑, 93,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   APE1/APEX1↓, 1,   ATM↓, 1,   ATM↑, 4,   p‑ATM↑, 3,   ATR↑, 1,   BRCA1↓, 2,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 2,   DFF45↑, 3,   DNA-PK↑, 2,   DNAdam↓, 4,   DNAdam↑, 154,   mt-DNAdam↑, 2,   DNArepair↓, 5,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC3↑, 1,   ERCC4/XPF↓, 1,   FEN1↓, 1,   hTERT/TERT↓, 18,   Ku70/XRCC6↓, 2,   MGMT↓, 2,   NHEJ↓, 1,   p16↑, 6,   P53?, 1,   P53↓, 6,   P53↑, 204,   P53↝, 3,   P53∅, 2,   p‑P53↓, 1,   p‑P53↑, 12,   ac‑P53↑, 1,   p53 Wildtype↓, 2,   PARP↓, 11,   PARP↑, 65,   PARP↝, 2,   p‑PARP↑, 5,   cl‑PARP↓, 4,   cl‑PARP↑, 247,   cl‑PARP↝, 1,   cl‑PARP∅, 2,   proPARP↓, 2,   PARP1↓, 1,   PARP1↑, 9,   cl‑PARP1↑, 6,   PCNA↓, 52,   RAD51↓, 1,   SIRT6↑, 1,   SMG1↑, 1,   Telomerase↓, 18,   TOP1↓, 6,   TOP2↓, 6,   TOP2↑, 1,   TP53↓, 3,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   XRCC1↓, 2,   γH2AX↓, 1,   γH2AX↑, 21,   γH2AX↝, 1,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   CC(CDKs/cyclins)↓, 1,   CDK1↓, 31,   CDK1↑, 4,   p‑CDK1↓, 2,   p‑CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 55,   CDK2↑, 5,   p‑CDK2↓, 1,   CDK4↓, 67,   CDK4↑, 6,   CDK4↝, 1,   p‑CDK4↓, 1,   CDK6↓, 28,   CDK6↑, 5,   CDK8↓, 1,   CDKN2C/p18↑, 1,   CHK1↓, 4,   CHK1↑, 1,   p‑CHK1↓, 1,   p‑CHK1↑, 2,   Chk2↓, 2,   Chk2↑, 1,   p‑Chk2↓, 1,   p‑Chk2↑, 1,   ChrCon↑, 2,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 16,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 50,   CycB/CCNB1↑, 6,   cycD1/CCND1↓, 150,   cycD1/CCND1↑, 6,   cycD1/CCND1↝, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 33,   cycE/CCNE↑, 1,   cycE1↓, 2,   cycF↑, 1,   E2Fs↓, 5,   FBXO5/EMI1↓, 1,   GADD45A↓, 1,   GADD45A↑, 2,   Ki-67↓, 53,   MAD↓, 1,   mitA↑, 6,   p19↑, 2,   P21?, 2,   P21↓, 14,   P21↑, 129,   P21↝, 2,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 51,   pRB↓, 1,   pRB↑, 3,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 7,   Securin↓, 2,   TubPol↓, 1,   TumCCA?, 2,   TumCCA↓, 10,   TumCCA↑, 386,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 2,   ALDH↓, 5,   ALDH1A1↓, 3,   Axin2↑, 1,   BMI1↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 2,   CD133↓, 10,   CD24↓, 2,   CD34↓, 2,   CEBPA↑, 1,   cFos↓, 10,   cFos↑, 1,   cMYB↓, 1,   CSCs?, 1,   CSCs↓, 48,   Diff↓, 1,   Diff↑, 2,   EIF4E↓, 2,   FGF↓, 4,   Gli↓, 3,   Gli1↓, 13,   HH↓, 11,   IGF-1↓, 13,   p‑IGF-1↓, 1,   IGF-2↓, 2,   IGF-2↑, 1,   IGFBP1↑, 2,   IGFBP3↑, 5,   JAG1↓, 1,   Jun↓, 2,   Ki-67↓, 53,   Let-7↓, 1,   Let-7↑, 4,   MCM2↓, 1,   mTORC1↓, 8,   p‑mTORC1↓, 1,   Nanog↓, 14,   Nanog↑, 1,   Nestin↓, 4,   NICD↓, 1,   NOTCH↓, 19,   NOTCH1↓, 17,   NOTCH1↑, 2,   NOTCH2↑, 1,   NOTCH3↓, 5,   OGFr↑, 2,   PCLAF↓, 1,   circ‑PLEKHM3↑, 1,   PTCH1↓, 2,   PTCH2↓, 2,   SCF↓, 2,   Shh↓, 14,   Smo↓, 7,   STAT1↓, 2,   Sufu↑, 1,   TAZ↓, 1,   TumCG?, 2,   TumCG↓, 188,   TumCG↑, 4,   TumCP?, 1,   TumCP↓, 300,   TumCP↑, 5,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt?, 1,   Wnt↓, 49,   Wnt↑, 1,   Wnt/(β-catenin)↓, 7,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 13,   AP-1↑, 1,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 2,   BACH1↓, 1,   Ca+2↓, 9,   Ca+2↑, 60,   Ca+2↝, 8,   i-Ca+2?, 1,   i-Ca+2↑, 6,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal1↑, 2,   cal2↓, 1,   cal2↑, 6,   CCN2/CTGF↓, 1,   Cdc42↓, 2,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 2,   COL3A1↓, 1,   DLC1↑, 2,   E-cadherin↓, 9,   E-cadherin↑, 64,   EM↑, 1,   EMT?, 1,   EMT↓, 89,   EMT↑, 3,   EMT↝, 1,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 23,   p‑FAK↓, 4,   p‑FAK↑, 1,   Fibronectin↓, 5,   GIT1↓, 1,   GLI2↓, 6,   hnRNPA1↓, 1,   IQGAP3↓, 1,   ITGA5↓, 2,   ITGB1↓, 3,   ITGB3↓, 2,   ITGB4↓, 1,   LAMs↓, 2,   LEF1↓, 3,   LIMK2↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 3,   MET↑, 1,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 6,   MMP13↓, 4,   MMP15↓, 1,   MMP16↓, 2,   MMP2↓, 127,   MMP2↝, 1,   proMMP2↓, 1,   MMP3↓, 10,   MMP7↓, 14,   MMP9↓, 146,   MMP9↑, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 45,   MTA1↓, 2,   MUC4↓, 1,   N-cadherin?, 1,   N-cadherin↓, 46,   p44↓, 1,   p‑p44↓, 1,   PAI-1/SERPINE1↑, 1,   PAK1↓, 2,   pax↓, 1,   p‑pax↓, 1,   PCBP1↓, 1,   PDGF↓, 6,   proline↓, 1,   Rac1↓, 3,   RECK↑, 1,   Rho↓, 4,   Rho↑, 1,   ROCK1↓, 3,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 20,   Smad1↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 4,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↓, 1,   p‑SMAD4↓, 2,   Snail?, 1,   Snail↓, 43,   TET1↑, 6,   TGF-β↓, 20,   TGF-β↑, 5,   TGF-β1↓, 1,   THBS1↑, 1,   TIMP1↓, 5,   TIMP1↑, 18,   TIMP2↓, 4,   TIMP2↑, 17,   TIMP3↑, 1,   TPM4↓, 1,   TRIB3↑, 2,   TSC1↑, 1,   TSP-1↑, 3,   TumCA↓, 4,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 124,   TumCI↑, 1,   TumCMig↓, 119,   TumCMig↑, 1,   TumMeta?, 1,   TumMeta↓, 87,   TumMeta↑, 5,   TumPF↓, 4,   Twist↓, 21,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 26,   uPA↝, 1,   uPAR↓, 1,   UroPA↓, 1,   Vim↓, 49,   Vim↑, 1,   Zeb1↓, 15,   Zeb1↑, 1,   ZEB2↓, 3,   α-SMA↓, 1,   α-tubulin↓, 3,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 62,   β-catenin/ZEB1↑, 3,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 117,   angioG↑, 2,   CD31/PECAM-1↓, 12,   EGR1↑, 1,   Endoglin↑, 3,   eNOS↓, 3,   eNOS↑, 1,   HIF-1↓, 4,   Hif1a↓, 90,   Hif1a↑, 2,   NO↓, 5,   NO↑, 4,   NO↝, 1,   VCAM-1↓, 4,   VEGF↓, 151,   VEGF↑, 2,   VEGF↝, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 23,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 6,   BBB∅, 2,   CellMemb↓, 1,   CellMemb↑, 1,   CLDN1↓, 3,   CLDN1↑, 1,   CLDN2↓, 2,   CLDN2↑, 1,   CX43/GJA1↓, 1,   EPR↑, 6,   GLUT1↓, 18,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 2,   IBI↑, 1,   KCNH2/hERG↓, 1,   memfluid↓, 1,   MMP?, 3,   MMP↓, 329,   MMP↑, 4,   MMP↝, 1,   MMP∅, 2,   MPT↑, 14,   NHE1↓, 2,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2↝, 1,   TJ↑, 1,   TRPM7↓, 3,   TRPV1↑, 4,   TRPV1↝, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CCR7↓, 2,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 5,   CD44↓, 17,   CD47↓, 1,   CD8+↑, 3,   cDC2↓, 5,   p‑cDC2↓, 1,   p‑cDC2↑, 1,   COX1?, 1,   COX1↓, 2,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 110,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 3,   CXCR2↓, 1,   CXCR4↓, 16,   CXCR4↑, 1,   DCells↑, 1,   DR4↑, 12,   DR4∅, 1,   DR6↑, 1,   FOXP3↓, 2,   FOXP3↑, 2,   Gal-3↓, 1,   HLA-I/II↑, 1,   HMGB1↓, 5,   HMGB1↑, 1,   ICAM-1↓, 6,   IFN-γ↓, 4,   IFN-γ↑, 4,   Igs↓, 1,   IL1↓, 5,   IL1↑, 2,   IL10↓, 8,   IL10↑, 2,   IL12↓, 2,   IL12↑, 1,   IL17↓, 2,   IL18↓, 1,   IL18↑, 1,   IL1α↓, 1,   IL1β↓, 22,   IL1β↑, 5,   IL2↓, 2,   IL2↑, 6,   IL22↓, 1,   IL23↓, 1,   IL4↓, 3,   IL4↑, 2,   IL5↓, 1,   IL6↓, 66,   IL6↑, 1,   IL6↝, 1,   IL8↓, 13,   Imm↑, 16,   Imm↝, 3,   Inflam↓, 47,   pol-M1↑, 1,   MCP1/CCL2↓, 6,   MCT1↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NAF1↓, 1,   NF-kB↓, 211,   NF-kB↑, 11,   NF-kB↝, 1,   p‑NF-kB↓, 3,   p‑NF-kB↑, 2,   NK cell↑, 7,   NLRP3↓, 3,   NLRP3↑, 2,   NOD1↓, 1,   p50↓, 3,   p65↓, 11,   p‑p65↓, 3,   ac‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 9,   PGE2↓, 26,   PSA↓, 11,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   RANTES?, 1,   SOCS-3↓, 1,   SOCS1↑, 1,   T-Cell↑, 2,   T-Cell↝, 1,   TCF↓, 2,   TCF↑, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR4↓, 11,   TLR4↝, 1,   TNF-α↓, 52,   TNF-α↑, 11,   TNF-α↝, 1,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 4,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   GGT/CD224↑, 1,   IM↓, 1,   pH↓, 1,   pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 1,   PTN↓, 1,   SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   ACE/ACE1↓, 1,   AhR↑, 1,   AR↓, 21,   AR↝, 1,   AR-V7?, 1,   CYP19?, 1,   ER-α36↓, 5,   ER(estro)↓, 1,   GR↑, 1,   PPARα↓, 4,   cl‑PPARα↓, 1,   PPARγ↓, 4,   PPARγ↑, 8,   RANKL↓, 1,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 48,   BioAv↑, 56,   BioAv↝, 11,   BioEnh↑, 6,   ChemoSen?, 2,   ChemoSen↓, 3,   ChemoSen↑, 201,   ChemoSen↝, 1,   CompStab↓, 3,   CompStab↑, 5,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1B1↑, 1,   CYP3A4↓, 2,   DDS↑, 2,   Dose?, 12,   Dose↓, 5,   Dose↑, 11,   Dose⇅, 1,   Dose↝, 92,   Dose∅, 18,   eff↓, 138,   eff↑, 136,   eff↝, 16,   eff∅, 5,   GSTA1↓, 1,   GSTA1↑, 2,   Half-Life↓, 12,   Half-Life↑, 2,   Half-Life↝, 12,   Half-Life∅, 1,   MDR1↓, 6,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 19,   P450↓, 5,   RadioS?, 1,   RadioS↑, 60,   selectivity?, 2,   selectivity↓, 1,   selectivity↑, 166,   selectivity∅, 1,   Synergy?, 1,   Synergy↑, 140,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 4,   ALAT↓, 6,   ALAT↑, 1,   ALAT↝, 1,   ALP↓, 4,   ALP↝, 1,   AR↓, 21,   AR↝, 1,   ascitic↓, 1,   AST↓, 5,   AST↑, 1,   AST↝, 1,   BG↓, 1,   BloodF↓, 1,   BRAF↓, 2,   BRAF↝, 1,   BRCA1↓, 2,   p‑BRCA1↑, 1,   CA19-9↓, 1,   CEA↓, 3,   CRP↓, 3,   E6↓, 5,   E7↓, 4,   EGFR↓, 49,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 3,   EZH2↓, 2,   Ferritin↓, 3,   FOXM1↓, 8,   HER2/EBBR2↓, 19,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 18,   IL6↓, 66,   IL6↑, 1,   IL6↝, 1,   LDH?, 1,   LDH↓, 22,   LDH↑, 11,   LDH↝, 2,   i-LDH↓, 1,   Myc↓, 6,   NSE↓, 1,   PD-L1↓, 9,   PSA↓, 11,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   TG/TAG↓, 1,   TP53↓, 3,   TP53↑, 3,   TRIB3↑, 2,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 76,   AntiCan∅, 1,   antiCG↓, 1,   antiD↑, 1,   antiNeop↑, 4,   AntiTum↓, 1,   AntiTum↑, 37,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 4,   cardioP↑, 10,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 37,   chemoPv↑, 31,   ChemoSideEff↓, 11,   ChemoSideEff∅, 1,   cognitive↑, 1,   hepatoP↓, 1,   hepatoP↑, 11,   memory↑, 2,   neuroP↑, 11,   NP/CIPN↓, 1,   OS↑, 20,   OS⇅, 1,   Pain↓, 4,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 3,   QoL↑, 7,   QoL∅, 1,   radioP↑, 9,   Remission↑, 1,   RenoP↑, 13,   Risk↓, 20,   Sleep↑, 1,   Strength↑, 4,   TGFβR1↓, 1,   toxicity?, 1,   toxicity↓, 23,   toxicity↑, 8,   toxicity↝, 10,   toxicity∅, 2,   TumNum↓, 3,   TumVol↓, 58,   TumVol↑, 2,   TumW↓, 27,   Weight↓, 1,   Weight↑, 4,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 1,   AntiP↑, 1,   Bacteria↓, 4,   Bacteria↑, 1,   GutMicro↑, 4,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 3,   Ingr↝, 9,  
Total Targets: 1449

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx?, 1,   antiOx↓, 7,   antiOx↑, 133,   ARE↑, 2,   Bil↓, 1,   Catalase↓, 1,   Catalase↑, 70,   Copper↓, 1,   Fenton↓, 3,   GCLC↝, 1,   GCLM↝, 1,   GPx↑, 54,   GPx1↑, 1,   GPx4↑, 2,   GSH↓, 2,   GSH↑, 78,   GSH/GSSG↑, 1,   GSR↓, 2,   GSR↑, 10,   GSTs↓, 3,   GSTs↑, 19,   H2O2↓, 6,   HDL↑, 4,   HO-1↓, 4,   HO-1↑, 35,   hyperG↝, 1,   Iron↓, 3,   Keap1↓, 3,   Keap1↑, 2,   Keap1↝, 2,   lipid-P↓, 50,   MDA?, 1,   MDA↓, 57,   MDA↑, 4,   MPO↓, 10,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 2,   NQO1↑, 5,   NQO1↝, 1,   NRF2↓, 2,   NRF2↑, 70,   Prx↑, 2,   RNS↓, 6,   ROS?, 1,   ROS↓, 180,   ROS↑, 9,   ROS⇅, 1,   ROS∅, 5,   mt-ROS?, 1,   SOD?, 1,   SOD↓, 3,   SOD↑, 91,   SOD1↑, 4,   SOD2↑, 3,   TAC↑, 9,   TBARS↓, 4,   Thiols↑, 1,   Trx↑, 2,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FPN↑, 1,   IronCh↑, 3,   IronCh↝, 1,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 2,   FIS1↓, 1,   Insulin↑, 3,   MFN2↑, 2,   mitResp↑, 1,   mtDam↓, 5,   PGC-1α↓, 1,   PGC-1α↑, 4,   PGC-1α↝, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 3,   adiP↑, 1,   ALAT↓, 23,   AMPK↓, 1,   AMPK↑, 15,   ATP↓, 3,   ATP↑, 11,   cAMP↑, 2,   DGAT1↓, 1,   FASN↓, 1,   FFA/NEFA↓, 1,   GAPDH↑, 1,   glucose↓, 6,   glucose↝, 4,   GlucoseCon↑, 1,   GlutMet↑, 1,   GSK‐3β↓, 10,   GSK‐3β↑, 3,   p‑GSK‐3β↑, 1,   H2S↑, 2,   HMG-CoA↓, 2,   LDHA↑, 1,   LDL↓, 7,   lipidLev↓, 3,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 4,   NADPH↑, 3,   NH3↓, 1,   PLA2↓, 2,   SIRT1↑, 11,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 3,   APAF1↓, 2,   Apoptosis↓, 46,   Apoptosis∅, 1,   ASC↓, 1,   BAD↓, 3,   BAX↓, 47,   BAX↑, 4,   Bax:Bcl2↓, 8,   Bax:Bcl2↑, 3,   Bcl-2↓, 9,   Bcl-2↑, 31,   Bcl-xL↓, 1,   Bcl-xL↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp12↓, 3,   Casp3?, 1,   Casp3↓, 104,   Casp3↑, 10,   Casp3∅, 2,   cl‑Casp3↓, 20,   cl‑Casp3↑, 1,   proCasp3↓, 2,   proCasp3↑, 1,   Casp7↓, 1,   Casp8↓, 5,   Casp8↑, 1,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 27,   Casp9↑, 4,   Casp9∅, 1,   cl‑Casp9↓, 3,   cl‑Casp9↑, 1,   Cyt‑c↓, 17,   Cyt‑c↑, 1,   Cyt‑c∅, 2,   Fas↓, 2,   Fas↑, 2,   FasL↓, 1,   Ferroptosis↓, 3,   GSDMD↓, 1,   iNOS↓, 26,   iNOS↑, 3,   MLKL↓, 1,   necrosis↓, 1,   p38↓, 3,   p38↑, 1,   p‑p38↓, 2,   Pyro↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 8,   Akt↑, 10,   p‑Akt↓, 4,   p‑Akt↑, 9,   Akt2↓, 1,   CaMKII ↓, 1,   CREB↑, 4,   p‑CREB↑, 3,   EGFR↓, 1,   ERK↓, 6,   ERK↑, 5,   p‑ERK↓, 1,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 2,   IKKα↑, 1,   IκB?, 1,   IκB↑, 1,   JAK↓, 2,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 6,   JNK↑, 3,   p‑JNK↓, 2,   MAPK↓, 19,   MAPK↑, 3,   Mst1↓, 1,   mTOR↓, 3,   mTOR↑, 4,   p‑mTOR↓, 4,   p‑mTOR↑, 2,   p‑p70S6↓, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 8,   PI3K↑, 8,   PKCδ?, 1,   PKCδ↓, 1,   PKCδ↑, 1,   PTEN↓, 2,   RAS↓, 1,   RIP1↓, 2,   STAT↓, 1,   STAT3↓, 2,   STAT3↑, 4,   p‑STAT3↑, 1,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   ATF4↓, 1,   cJun↓, 2,   p‑cJun↓, 2,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO3↑, 1,   HDAC↓, 3,   HDAC2↓, 1,   HDAC3↓, 1,   HOTAIR↑, 1,   other↓, 3,   other↑, 6,   other↝, 12,   RUNX2↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 7,   CHOP/DDIT3↑, 1,   ER Stress↓, 8,   GRP78/BiP↓, 7,   GRP78/BiP↑, 2,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↑, 5,   HSP90↓, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↓, 3,   PERK↓, 2,   UPR↓, 3,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 3,   LC3II↓, 1,   LC3II↑, 4,   MitoP↑, 1,   p62↓, 1,   p62↑, 4,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 9,   p16↓, 1,   P53↓, 7,   P53↑, 2,   PARP↓, 2,   PARP∅, 1,   p‑PARP↓, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 2,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 2,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 4,   P21↑, 2,   RB1↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↓, 1,   Diff↑, 2,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 1,   Ki-67↓, 1,   neuroG↑, 3,   TumCG↓, 1,   TumCP↓, 4,  

Migration(tgid=13) ⓘ

AntiAg↑, 9,   AP-1↓, 3,   mt-ATPase↑, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 7,   Ca+2↑, 1,   Ca+2↝, 3,   cal2↓, 1,   Cartilage↑, 1,   COL1↓, 2,   COL1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 2,   MMP2↑, 1,   MMP3↓, 3,   MMP7↓, 1,   MMP9↓, 5,   MUC1↑, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 6,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 1,   Vim↓, 1,   Zeb1↓, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 2,   eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 4,   Hif1a↑, 1,   NO?, 1,   NO↓, 21,   NO↑, 5,   VCAM-1↓, 4,   VEGF↓, 3,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 2,   BBB↑, 19,   BBB↝, 1,   BBB∅, 2,   CLDN1↓, 1,   CLDN5↓, 1,   GastroP↑, 6,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 6,   MMP↑, 23,   MMP∅, 1,   MUC5AC↓, 1,   OCLN↓, 2,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 3,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPM7⇅, 1,   TRPV1↑, 1,   ZO-1↓, 4,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 3,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 5,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 40,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 9,   IL10↑, 8,   IL12↓, 2,   IL13↑, 1,   IL17↓, 2,   IL18↓, 3,   IL1β↓, 51,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 1,   IL33↓, 1,   IL4↓, 2,   IL4↑, 1,   IL5↓, 1,   IL6↓, 59,   IL6↑, 1,   IL8↓, 7,   Imm↓, 1,   Imm↑, 8,   Imm⇅, 1,   INF-γ↓, 2,   Inflam↓, 161,   Inflam↑, 2,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   MyD88↓, 2,   NeuroI↓, 5,   NF-kB↓, 65,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 10,   p65↓, 2,   PAF↑, 1,   PGE2↓, 20,   PGE2↑, 3,   RAGE↓, 2,   RANTES↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 9,   TNF-α↓, 85,   TNF-α↑, 2,   Treg lymp↝, 1,   TRIF↓, 2,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 5,   Ach↑, 6,   AChE↓, 25,   BChE↓, 6,   BDNF↓, 2,   BDNF↑, 24,   BDNF⇅, 1,   BDNF∅, 1,   ChAT↑, 4,   DA↑, 1,   GABA↑, 1,   MAOA↓, 2,   MAOB↓, 1,   NGF↑, 4,   PSD95↑, 5,   SNAP25↑, 2,   TPH1↓, 1,   TrkB↑, 3,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 2,   Aβ↓, 27,   Aβ42↓, 6,   BACE/β-secretase↓, 9,   IDE↑, 1,   tau↓, 7,   p‑tau↓, 7,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE/ACE1↑, 1,   ACE2↓, 1,   BNP↓, 1,   CYP19↓, 1,   Estro↓, 1,   FGF21↑, 1,   GR↑, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 9,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 48,   BioAv↑, 47,   BioAv⇅, 1,   BioAv↝, 22,   BioAv∅, 1,   BioEnh↑, 2,   ChemoSen↑, 2,   CompStab↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 22,   Dose∅, 2,   eff↓, 5,   eff↑, 21,   eff↝, 1,   GSTA1↑, 2,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 14,   Half-Life∅, 3,   MRP↓, 1,   P-gp/ABCB1↓, 2,   P450↓, 3,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 12,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 23,   ALB↝, 1,   ALP↓, 6,   anemia↓, 1,   AST↓, 24,   BG↓, 1,   Bil↓, 1,   BloodF↑, 2,   BMD↑, 2,   BP↓, 5,   BUN?, 1,   BUN↓, 4,   CEA↓, 1,   colonLen↑, 1,   creat↓, 9,   CRP↓, 7,   EGFR↓, 1,   Ferritin↓, 1,   HemoG↑, 1,   hs-CRP↓, 1,   IL6↓, 59,   IL6↑, 1,   IRes↝, 1,   LDH↓, 12,   NOS2↓, 1,   RAGE↓, 2,   RBC↑, 1,   SpO2↑, 1,   TG/TAG↓, 2,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 7,   antiAll↑, 22,   AntiArt↑, 12,   AntiCan↑, 26,   antiCG↑, 3,   antiD↓, 1,   AntiDiabetic↑, 35,   antiNeop↑, 1,   antiPs↑, 3,   AntiTum↓, 2,   AntiTum↑, 7,   cardioP?, 1,   cardioP↑, 55,   chemoP↑, 12,   chemoPv↑, 6,   cognitive↓, 1,   cognitive↑, 36,   diuretic↑, 3,   GFR↑, 1,   hepatoP↓, 1,   hepatoP↑, 53,   Learn↑, 4,   memory↑, 34,   Mood↑, 1,   motorD↑, 7,   Mucositis↓, 2,   neuroP?, 1,   neuroP↓, 2,   neuroP↑, 100,   Obesity↓, 12,   OS↑, 3,   Pain↓, 4,   radioP↑, 8,   RenoP↓, 1,   RenoP↑, 19,   Risk↓, 1,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 14,   toxicity?, 1,   toxicity↓, 60,   toxicity↑, 4,   toxicity↝, 8,   toxicity∅, 11,   Weight↑, 1,   Weight∅, 1,   Wound Healing↑, 7,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 15,   AntiFungal↓, 1,   AntiFungal↑, 5,   AntiP↓, 1,   AntiP↑, 4,   AntiViral↑, 15,   Bacteria↓, 32,   Diar↓, 3,   GutMicro↑, 17,   Inf↓, 1,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr↑, 1,   Ingr↝, 6,   Phen↑, 1,   QC↑, 1,  
Total Targets: 616

Scientific Paper Hit Count for: Casp3, CPP32, Cysteinyl aspartate specific proteinase-3
38 Silver-NanoParticles
35 Quercetin
32 Curcumin
29 Thymoquinone
26 Apigenin (mainly Parsley)
23 Sulforaphane (mainly Broccoli)
22 Luteolin
21 Baicalein
21 Berberine
18 EGCG (Epigallocatechin Gallate)
18 Emodin
18 Fisetin
17 Shikonin
16 Cisplatin
16 Propolis -bee glue
16 Chrysin
16 Honokiol
14 Artemisinin
14 Magnetic Fields
14 Allicin (mainly Garlic)
14 Capsaicin
14 Licochalcone A
14 Magnolol
13 Ashwagandha(Withaferin A)
13 Radiotherapy/Radiation
13 Kaempferol
12 Betulinic acid
12 Benzyl isothiocyanate
12 Boron
12 Silymarin (Milk Thistle) silibinin
11 doxorubicin
11 Eugenol
11 Gambogic Acid
11 Hyperoside
11 Morin
10 Chlorogenic acid
10 Ginkgetin
10 Graviola
10 isoorientin
10 Juglone
10 Lycopene
10 Matrine
10 Resveratrol
9 Alpha-Lipoic-Acid
9 Carvacrol
9 Phenylbutyrate
8 5-fluorouracil
8 D-limonene
8 Phenethyl isothiocyanate
8 Citric Acid
8 Dandelion Root
8 Formononetin
8 Garcinol
8 Ivermectin
7 Allyl isothiocyanate
7 Melatonin
7 Gallic acid
7 Isobavachalcone
7 Vitexin
7 L-Theanine
7 mebendazole
7 Piperlongumine
7 Rosmarinic acid
6 Beta-Caryophyllene
6 Bufalin/Huachansu
6 chaetocin
6 chitosan
6 Ferulic acid
6 phytic acid, Inositol hexakisphosphate
6 Isoliquiritigenin
6 Licorice
6 Nimbolide
6 Selenite (Sodium)
6 Vitamin K2
5 Boswellia (frankincense)
5 α-Bisabolol / Chamomile oil
5 Caffeic acid
5 Chemotherapy
5 Centella asiatica / Gotu kola → asiaticoside
5 Crocetin
5 Ursolic acid
5 Dichloroacetate
5 salinomycin
5 Ellagic acid
5 Paclitaxel/Taxol
5 Evodiamine
5 Isorhamnetin
5 isoquercitrin
5 lambertianic acid
5 Linalool
5 Magnetic Field Rotating
5 Mangiferin
5 Mushroom Lion’s Mane, Hericium erinaceus
5 Plumbagin
5 Aflavin-3,3′-digallate
4 3-bromopyruvate
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Anethole/trans-Anethole
4 Astaxanthin
4 Photodynamic Therapy
4 Bromelain
4 borneol
4 Carvone
4 Cucurbitacin
4 Geraniol
4 Isovitexin
4 Lemongrass Extract/Citral
4 Lutein
4 methylseleninic acid
4 Moringa oleifera
4 Naringin
4 Marjoram (Origanum majorana)
4 Propyl gallate
4 Piperine
4 VitK3,menadione
4 Urolithin
3 Açaí, Euterpe oleracea
3 Auranofin
3 Metformin
3 Berbamine
3 Biochanin A
3 Brucea javanica
3 Carnosic acid
3 Thymol-Thymus vulgaris
3 Celastrol
3 Cynaropicrin
3 Deguelin
3 Date Fruit Extract
3 Docetaxel
3 Echinacea
3 Fenbendazole
3 Fucoidan
3 Ginkgo biloba
3 Ginkgolide B
3 Gossypol/AT-101
3 Hydrogen Gas
3 Hydroxycinnamic-acid
3 Hibiscus sabdariffa
3 Helleborus niger extracts – Christmas Rose
3 Rutin
3 itraconazole
3 Laetrile B17 Amygdalin
3 Methylsulfonylmethane
3 Patchouli Oil (Pogostemon cablin)
3 Phycocyanin
3 Psoralidin
3 Pterostilbene
3 α-Santalol/Sandalwood oil
3 Vitamin C (Ascorbic Acid)
2 1,8-Cineole
2 Coenzyme Q10
2 Astragalus
2 SonoDynamic Therapy UltraSound
2 entinostat
2 Gemcitabine (Gemzar)
2 tamoxifen
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Andrographis
2 Fennel Oil/Foeniculum vulgare
2 Aloe anthraquinones
2 brusatol
2 Bullatacin
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Cat’s Claw
2 Cichoric acid / Chicoric acid
2 methotrexate
2 Cinnamon
2 Citicoline, CDP-Choline
2 Copper and Cu NanoParticles
2 Oxaliplatin
2 Diclofenac
2 diet FMD Fasting Mimicking Diet
2 Ginkgo biloba-EGb 761
2 Electrical Pulses
2 Eurycomanone
2 Flaxseed/Linseed
2 carboplatin
2 Ginkgolic acids
2 Ginger/6-Shogaol/Gingerol
2 HydroxyCitric Acid
2 HydroxyTyrosol
2 Huperzine A/Huperzia serrata
2 Inositol
2 low dose naltrexone
2 Lactoferrin/Talactoferrin
2 Methyl Jasmonate
2 Magnesium
2 Mistletoe/Viscum album Extracts
2 Mushroom Chaga, Inonotus obliquus
2 Oleuropein
2 Parthenolide
2 Selenium
2 Selenium NanoParticles
2 Vitamin D3
2 Zyflamend
1 5-Aminolevulinic acid
1 Camptothecin
1 Resiquimod
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Angelica archangelica / Garden Angelica
1 2-DeoxyGlucose
1 Ascorbyl Palmitate
1 Trastuzumab
1 almonertinib
1 epirubicin
1 temozolomide
1 Bacopa monnieri
1 Beetroot
1 Black turtle bean
1 Butyrate
1 Mung Bean Sprouts
1 Sorafenib (brand name Nexavar)
1 immunotherapy
1 Polyphenols
1 CUSP9
1 Chlorella (Chlorella vulgaris)
1 Dichloroacetophenone(2,2-)
1 diet Methionine-Restricted Diet
1 Cannabichromene
1 eicosapentaenoic acid
1 ferumoxytol
1 Geldanamycin
1 Radicicol/monorden
1 Bortezomib
1 Flaxseed Oil
1 Galloflavin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 hydrogen sulfide
1 Orlistat
1 Hyperthermia
1 Indole-3-carbinol
1 iodine
1 Inulin Prebiotic
1 Lactobacillus
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lapachol
1 Lasiodin
1 Dordaviprone; Modeyso
1 MCT, metronomic chemo
1 Modified Citrus Pectin
1 Moringin
1 magnetic nanoparticles
1 Iron
1 Lemon Balm/Melissa officinalis
1 Myricetin
1 nelfinavir/Viracept
1 sericin
1 Purple Corn / Purple Maize
1 topotecan
1 isoflavones
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Sanguinarine
1 Scoulerine
1 polyethylene glycol
1 Folic Acid, Vit B9
1 Sesamin
1 Lignans
1 Spirulina(Arthrospira/Limnospira)
1 Osimertinib
1 Adagrasib
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 triptolide
1 Turmerones
1 Vitamin B1/Thiamine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:42  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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