lipid-P Cancer Research Results

lipid-P, lipid peroxidation: Click to Expand ⟱
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Type:
Lipid peroxidation is a chain reaction process in which free radicals (often reactive oxygen species, or ROS) attack lipids containing carbon-carbon double bonds, especially polyunsaturated fatty acids. This attack results in the formation of lipid radicals, peroxides, and subsequent breakdown products.
Lipid peroxidation can cause damage to cell membranes, leading to increased permeability and disruption of cellular functions. This damage can initiate a cascade of events that may contribute to carcinogenesis.
The byproducts of lipid peroxidation, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), can form adducts with DNA, leading to mutations. These mutations can disrupt normal cellular processes and contribute to the development of cancer.
Lipid peroxidation damages cell membranes, disrupts cellular functions, and can trigger inflammatory responses. It is a marker of oxidative stress and is implicated in many chronic diseases.

Negative Prognostic Indicator: In many cancers, high levels of lipid phosphates, particularly S1P, are associated with poor prognosis, indicating a more aggressive tumor phenotype and potential resistance to therapy.
Mixed Evidence: The prognostic significance of lipid phosphates can vary by cancer type, with some studies showing that their expression may not always correlate with adverse outcomes.
Scientific Papers found: Click to Expand⟱
5125- Sal,    Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma
- in-vitro, GBM, NA
ER Stress↑, UPR↑, autoF↓, lysosome↝, ROS↑, lipid-P↑, CSCs↓, necrosis↑, ATP↓, MMP↓, MOMP↑, DNAdam↑, AIF↑, lysoMP↑, MitoP↑, Ca+2↑,
5039- SAS,    Regulatory network of ferroptosis and autophagy by targeting oxidative stress defense using sulfasalazine in triple-negative breast cancer
- vitro+vivo, BC, NA
xCT/SLC7A11↓, ROS↑, GSH↓, Ferroptosis↑, TumCG↓, toxicity↓, lipid-P↑,
4613- Se,  Rad,    Effect of Selenium and Selenoproteins on Radiation Resistance
- Review, Nor, NA
*selenoP↑, *GPx1↑, *GPx4↑, *lipid-P↓, *DNAdam↓, *ROS↓, *radioP↑,
4712- Se,    Selenium and selenoproteins: key regulators of ferroptosis and therapeutic targets in cancer
- Review, Var, NA
selenoP↑, Ferroptosis↑, lipid-P↑,
4603- SeNPs,    Therapeutic applications of selenium nanoparticles
- Review, Var, NA
AntiCan↑, Imm↑, *AntiDiabetic↑, *antiOx↑, *Inflam↓, ROS↑, ER Stress↑, DNAdam↑, *toxicity↓, *eff↑, *BioAv↑, selectivity↑, TumCCA↑, Risk↓, *lipid-P↓, *TNF-α↓, *CRP↓, TumMeta↓, angioG↓, selectivity↑, Synergy↑, *Synergy↑,
4440- SeNPs,  AgNPs,    Selenium, silver, and gold nanoparticles: Emerging strategies for hepatic oxidative stress and inflammation reduction
- Review, Nor, NA
*hepatoP↑, *antiOx↑, *Inflam↓, *ROS↓, *SOD↑, *GPx↑, *lipid-P↓,
4446- SeNPs,    Antioxidant and Hepatoprotective Effects of Moringa oleifera-mediated Selenium Nanoparticles in Diabetic Rats.
- in-vivo, Diabetic, NA
*glucose↓, *antiOx↑, *GPx↑, *Catalase↑, *SOD↑, *ROS↓, *cardioP↑, *HDL↑, *LDL↓, *hepatoP↑, *TNF-α↓, *IL6↓, *IL1β↓, *lipid-P↓, *Inflam↓, *ALAT↓, *AST↓, *ALP↓, *Dose↝, *Dose↝,
4443- SeNPs,    Bioogenic selenium and its hepatoprotective activity
- in-vivo, LiverDam, NA
*hepatoP↑, *AST↓, *ALAT↓, *LDH↓, *lipid-P?,
1483- SFN,    Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment
- in-vitro, OS, 143B - in-vitro, Nor, HEK293 - in-vivo, OS, NA
AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,
3946- Shank,    Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies
- Review, AD, NA
*neuroP↑, *cognitive↑, *AChE↓, *antiOx↑, *GSR↑, *SOD↑, *GSH↑, *Inflam↓, *ROS↓, *lipid-P↓, *cardioP↑,
3315- SIL,    Silymarin alleviates docetaxel-induced central and peripheral neurotoxicity by reducing oxidative stress, inflammation and apoptosis in rats
- in-vivo, Nor, NA
neuroP↑, *NRF2↑, *HO-1↑, *lipid-P↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *NF-kB↓, *TNF-α↓, *JNK↓, *Bcl-2↑, *BAX↑,
3314- SIL,    Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *Half-Life↑, *ROS↓, *GSH↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *IFN-γ↓, *IL2↓, *IL4↓, *NF-kB↓, *iNOS↓, *OATPs↓, *OCT4↓, *Inflam↓, *PGE2↓, MMPs↓, VEGF↓, angioG↓, STAT3↓, *ALAT↓, *AST↓, Dose↝,
3300- SIL,    Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy
- Review, Var, NA
*ROS↓, *SOD↑, *hepatoP↑, *AST↓, *ALAT↓, *lipid-P↓, *GSH↑, *Catalase↑, *GSTs↑, *GSR↑, *TNF-α↓, *IFN-γ↓, *IL4↓, *IL2↓, *NF-kB↓, *IL10↑, *Inflam↓, COX2/PTGS2↓, Apoptosis↑, ChemoSen↑, PGE2↓, VEGF↓,
3295- SIL,    Hepatoprotective effect of silymarin
- Review, Var, NA
*hepatoP↑, *ROS↓, *GSH↑, *BioAv↝, ERK↓, NF-kB↓, STAT3↓, COX2/PTGS2↓, Inflam↓, IronCh↑, lipid-P↓, ALAT↓, AST↓, TNF-α↓, *α-SMA↓, *SOD↑,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2/PTGS2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27/CDKN1B↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, Synergy↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2/PTGS2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,
3331- SIL,    The clinical anti-inflammatory effects and underlying mechanisms of silymarin
- Review, Nor, NA
*Inflam↓, *NF-kB↓, *NLRP3↓, *COX2/PTGS2↓, *iNOS↓, *neuroP↑, *p‑ERK↓, *p38↓, *MAPK↓, *EGFR↓, *ROS↓, *lipid-P?, *5LO↓,
3655- SIL,    Protective effect of silymarin on oxidative stress in rat brain
- in-vivo, AD, NA
*GSH↑, *VitC↑, *SOD↑, *lipid-P↓, *ROS↓, *hepatoP↑, *neuroP↑,
3649- SIL,    Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis
- in-vitro, Nor, NA
*Inflam↓, *NF-kB↓, *cJun↓, *Casp↓, *ROS↓, *lipid-P↓,
3648- SIL,    Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years
- Review, Var, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *necrosis↓, *hepatoP↑, *IL1↓, *IL6↓, *TNF-α↓, *IFN-γ↓, MAPK↓, Apoptosis↑, Cyt‑c↑, Casp3↑, Casp9↑, *PPARγ↑, *GLUT4↑, *HSPs↓, *HSP27↑, *Trx↑, *SIRT1↑, *ALAT↓, *GSH↑, *lipid-P↓, *TNF-α↓, TumCG↓, P21↑, CDK4↑,
2201- SK,    Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice
- in-vitro, PSA, HaCaT - in-vivo, NA, NA
*eff↑, *IL6↓, *IL17↓, *TNF-α↓, *lipid-P↑, *NRF2↓, *HO-1↝, *NCOA4↝, *GPx4↓, *Ferroptosis↓, *Inflam↓, *ROS↓, *Iron↓,
2199- SK,    Induction of Ferroptosis by Shikonin in Gastric Cancer via the DLEU1/mTOR/GPX4 Axis
- in-vitro, GC, NA
ROS↑, lipid-P↑, Iron↑, MDA↑, GPx4↓, Ferritin↓, DLEU1↓, mTOR↓, Ferroptosis↑,
2198- SK,    Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis
- in-vitro, OS, MG63 - in-vitro, OS, 143B
TumCP↓, TumCCA↑, Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, mtDam↑, NRF2↓, xCT/SLC7A11↓, GPx4↓, GSH/GSSG↓, Keap1↑,
2227- SK,    Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, GES-1
selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,
2202- SK,    Enhancing Tumor Therapy of Fe(III)-Shikonin Supramolecular Nanomedicine via Triple Ferroptosis Amplification
- in-vitro, Var, NA
Iron↑, Ferroptosis↑, pH↝, H2O2↑, ROS↑, Fenton↑, GSH↓, GPx4↓, lipid-P↑,
1284- SK,    Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy
- in-vitro, Melanoma, RPMI-8226 - in-vitro, Melanoma, U266
Ferroptosis↑, LDH↓, ROS↑, Iron↑, lipid-P↑, ATP↓, HMGB1↓, GPx4↓, MDA↑, SOD↓, GSH↓,
9033- SP,    Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,
4892- Sper,  erastin,    Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer
- in-vitro, Pca, PC3 - in-vivo, Pca, NA
Ferroptosis↑, lipid-P↑, Iron↑, Synergy↑, HO-1↑, NRF2↑, ROS↑, AntiTum↑, eff↓,
5091- SSE,    Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
- in-vitro, GBM, U87MG - in-vitro, Cerv, HeLa - in-vitro, BC, MCF7 - in-vitro, Pca, PC3 - in-vitro, CRC, HT-29 - in-vitro, Nor, SVGp12
Ferroptosis↑, xCT/SLC7A11↓, GSH↓, GPx4↓, Iron↑, lipid-P↑, ROS↑, eff↓, TumCP↓, TumCD↑,
5088- SSE,    Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
- in-vitro, BC, MCF7 - in-vitro, GBM, U87MG - in-vitro, Pca, PC3 - in-vitro, Cerv, HeLa - in-vitro, GBM, A172
Ferroptosis↑, ROS↑, Iron↑, xCT/SLC7A11↓, GSH↓, GPx4↓, lipid-P↑, TumCP↓, selectivity↑,
4610- SSE,  Rad,    Protection during radiotherapy: selenium
- Review, Var, NA
*radioP↑, *antiOx↑, *Inflam↓, *DNAdam↓, *lipid-P↓, *selenoP↑, *GPx1↑, *BUN↓,
4718- SSE,    High-Dose Selenium Induces Ferroptotic Cell Death in Ovarian Cancer
- in-vitro, Ovarian, NA
TumCP↑, ROS↑, GPx↓, lipid-P↑, Ferroptosis↑, Dose↑,
3960- Taur,    Versatile Triad Alliance: Bile Acid, Taurine and Microbiota
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *Inflam↓, *GABA↑, *memory↑, *cognitive↑, *iNOS↓, *CRP↓, *HO-1↑, *Prx↑, *Trx↑, *NRF2↑, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *MDA↓, *eff↝, *GutMicro↑, other↑,
2113- TQ,    Potential role of Nigella sativa (NS) in abating oxidative stress-induced toxicity in rats: a possible protection mechanism
- in-vivo, Nor, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *SOD↑, *GSH↑, *ROS↓, *lipid-P↓, ALAT↓, creat↓,
2114- TQ,    Anti-Aging Effect of Nigella Sativa Fixed Oil on D-Galactose-Induced Aging in Mice
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *lipid-P↓, *GSH↑, *Bax:Bcl2↓, *proCasp3↓, *cl‑Casp3↓, *antiOx↑,
2124- TQ,    Thymoquinone: an emerging natural drug with a wide range of medical applications
- Review, Var, NA
hepatoP↑, Bax:Bcl2↑, cycD1/CCND1↓, P21↑, TRAIL↑, P53↑, TumCCA↑, hepatoP↑, *ALAT↓, *AST↓, *MDA↓, *GSSG↓, *COX2/PTGS2↓, *lipid-P↓, PPARγ↑, p38↑, ROS↑, ChemoSen↑, selectivity↑, selectivity↑, *MDA↓, *SOD↑, *antiAll↑,
2132- TQ,    Thymoquinone treatment modulates the Nrf2/HO-1 signaling pathway and abrogates the inflammatory response in an animal model of lung fibrosis
- in-vivo, Nor, NA
*Weight∅, *antiOx↑, *lipid-P↓, *MMP7↓, *Casp3↓, *BAX↓, *TGF-β↓, *Diff↑, *NRF2↓, *HO-1↓, *NF-kB↓, *IκB↑,
2136- TQ,    Nigella sativa and thymoquinone suppress cyclooxygenase-2 and oxidative stress in pancreatic tissue of streptozotocin-induced diabetic rats
- in-vivo, Nor, NA
*COX2/PTGS2↓, *lipid-P↓, *SOD↑, *ROS↓, *Inflam↓, *NF-kB↓,
2086- TQ,    Cardioprotective effects of Nigella sativa oil on cyclosporine A-induced cardiotoxicity in rats
- in-vivo, Nor, NA
*SOD↑, *Catalase↑, *GSH↑, *cardioP↑, *lipid-P↓,
2088- TQ,    Nigella sativa L. and Its Bioactive Constituents as Hepatoprotectant: A Review
- Review, Nor, NA
*hepatoP↑, *lipid-P↓, *Thiols↑, *ROS↓, *Catalase↑, *SOD↑, *GSTs↑, *NF-kB↓, *COX2/PTGS2↓, *LOX1↓,
2106- TQ,    Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy
- Review, Var, NA
Apoptosis↑, TumCCA↑, ROS↑, *Catalase↑, *SOD↑, *GR↑, *GSTA1↓, *GPx↑, *H2O2↓, *ROS↓, *lipid-P↓, *HO-1↑, p‑Akt↓, AMPKα↑, NK cell↑, selectivity↑, Dose↝, eff↑, GSH↓, eff↓, P53↑, p‑STAT3↓, PI3K↑, MAPK↑, GSK‐3β↑, ChemoSen↑, RadioS↑, BioAv↓, NRF2↑,
2110- TQ,    Nigella sativa seed oil suppresses cell proliferation and induces ROS dependent mitochondrial apoptosis through p53 pathway in hepatocellular carcinoma cells
- in-vitro, HCC, HepG2 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, Nor, HEK293
P53↑, lipid-P↑, GSH↓, ROS↑, MMP↓, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, tumCV↓, selectivity↑,
3400- TQ,  Chemo,    Thymoquinone Ameliorates Carfilzomib-Induced Renal Impairment by Modulating Oxidative Stress Markers, Inflammatory/Apoptotic Mediators, and Augmenting Nrf2 in Rats
- in-vitro, Nor, NA
*GSH↑, *SOD↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *Casp3↓, *Catalase↑, *NRF2↑, *RenoP↑,
3398- TQ,  5-FU,    Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo
- in-vivo, Nor, NA
*RenoP↑, *TAC↑, *ROS↓, *lipid-P↓, *p38↓, *MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *MDA↓, *GPx↑, *GSR↑, *Catalase↑, *BUN↓, *LDH↓, *IL1β↓,
3432- TQ,    Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *antiOx↑, *TLR1↓, *AChE↓, *MMP↑, *neuroP↑, *lipid-P↓, *SOD↑, *GSH↑, *Ach↑,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2/PTGS2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, Synergy↑, DNAdam↑, *iNOS↓,
6460- TUR,  CUR,    Neuroprotective Effect of Turmeric Extract in Combination with Its Essential Oil and Enhanced Brain Bioavailability in an Animal Model
- in-vivo, AD, NA
*memory↑, *lipid-P↓, *GSH↑, *AChE↑, *Catalase↑, *BioAv↑, *P-gp/ABCB1↓, *BioAv↑, *SOD↑, *BBB↑, *ROS↓,

Showing Research Papers: 351 to 400 of 415
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 415

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 1,   antiOx↑, 6,   antiOx⇅, 1,   Catalase↓, 11,   Catalase↑, 5,   Fenton↑, 9,   GPx↓, 9,   GPx↑, 7,   GPx4↓, 35,   GPx4↑, 1,   GPx4∅, 1,   GSH↓, 54,   GSH↑, 10,   GSH/GSSG↓, 5,   GSR↓, 1,   GSR↑, 2,   GSTs↓, 1,   GSTs↑, 3,   H2O2↓, 1,   H2O2↑, 7,   HNE↑, 1,   HO-1↓, 7,   HO-1↑, 14,   HO-1↝, 1,   Iron↓, 2,   Iron↑, 28,   i-Iron↓, 1,   i-Iron↑, 5,   c-Iron↑, 1,   Keap1↓, 2,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 30,   lipid-P↑, 116,   lipid-P↝, 2,   MDA?, 1,   MDA↓, 6,   MDA↑, 23,   i-MDA↑, 2,   NADH↓, 1,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NQO1↓, 2,   NQO1↑, 4,   NRF2↓, 14,   NRF2↑, 17,   ROS?, 1,   ROS↓, 16,   ROS↑, 151,   ROS⇅, 5,   ROS↝, 2,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 4,   selenoP↑, 1,   SOD?, 1,   SOD↓, 11,   SOD↑, 9,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   Trx↑, 1,   Trx1↓, 1,   Trx1↑, 1,   TrxR↓, 2,   TrxR1↓, 2,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 11,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 3,   FPN↝, 1,   FTH1↓, 2,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 2,   LIP↑, 1,   NCOA4↑, 2,   Tf↓, 1,   Tf↑, 2,   TfR1/CD71↑, 1,   TfR1/CD71↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC2↑, 1,   CDC25↓, 2,   CDC25↝, 1,   compI↓, 1,   compII↓, 1,   EGF↓, 1,   ETC↓, 4,   Insulin↓, 1,   MCU↓, 1,   MFN2↑, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 14,   OCR↑, 1,   OXPHOS↓, 1,   PDH↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↑, 1,   ACSL4↑, 3,   ACSL4↝, 1,   ALAT↓, 5,   AMPK↑, 14,   ATP↓, 9,   ATP↑, 1,   mt-ATP↓, 1,   citrate↓, 1,   FAO↑, 1,   FASN↓, 3,   FASN↑, 1,   FDG↓, 1,   G6PD↓, 2,   GAPDH↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↓, 4,   Glycolysis↓, 11,   GSK‐3β↓, 4,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 1,   HK2↓, 8,   HMG-CoA↓, 1,   KeyT↑, 1,   lactateProd↓, 5,   lactateProd↑, 1,   LDHA↓, 4,   LDL↓, 2,   lipoGen↓, 1,   NAD↓, 1,   NADPH↓, 2,   NADPH↑, 2,   PDK1 / PDPK1↓, 4,   PDK3↑, 1,   PFK↓, 1,   PFKP↓, 1,   PKM2↓, 2,   Pyruv↓, 1,   RNR↓, 1,   SCD1↓, 2,   SIRT1↓, 2,   SIRT1↑, 6,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 6,   APAF1↑, 5,   Apoptosis↓, 1,   Apoptosis↑, 86,   ASC↓, 1,   BAD↓, 1,   Bak↓, 1,   BAX↓, 2,   BAX↑, 48,   Bax:Bcl2↑, 6,   Bcl-2↓, 50,   Bcl-2↑, 4,   Bcl-xL↓, 5,   Bcl-xL↑, 1,   BID↑, 2,   BIM↓, 1,   BIM↑, 3,   BNIP3↑, 3,   Casp↑, 14,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 53,   cl‑Casp3↑, 9,   cl‑Casp3⇅, 1,   proCasp3↓, 1,   Casp7↑, 9,   cl‑Casp7↑, 2,   Casp8↑, 15,   cl‑Casp8↑, 2,   pro‑Casp8↑, 1,   Casp9↑, 34,   cl‑Casp9↑, 5,   proCasp9↓, 1,   CellShr↑, 1,   cFLIP↓, 2,   Cupro↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 36,   DR5↓, 1,   DR5↑, 10,   Endon↑, 1,   FADD↑, 4,   Fas↑, 8,   FasL↓, 1,   FasL↑, 3,   Ferroptosis↓, 1,   Ferroptosis↑, 57,   GranB/GZMB↝, 1,   HEY1↓, 1,   IAP1↓, 2,   iNOS↓, 8,   Mcl-1↓, 7,   MDM2↓, 3,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↑, 6,   Necroptosis↑, 1,   necrosis↑, 3,   NOXA↑, 1,   p38↓, 2,   p38↑, 8,   p‑p38↑, 1,   Paraptosis↑, 1,   Perforin↝, 1,   PUMA↑, 3,   survivin↓, 14,   TNFR 1↑, 1,   TRAIL↑, 1,   TumCD↑, 12,   XIAP↓, 6,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 53,   Akt↑, 2,   p‑Akt↓, 9,   AMPKα↑, 1,   CaMKII ↓, 1,   CK2↓, 1,   cMET↓, 1,   EGFR↓, 9,   EGFR↑, 2,   p‑EGFR↓, 1,   ERK↓, 16,   ERK↑, 3,   p‑ERK↓, 5,   FGFR1↓, 2,   FGFR2↓, 1,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   HRAS↓, 1,   IGF-1R↓, 2,   IKKα↓, 3,   JAK↓, 3,   JAK1↓, 1,   JAK2↓, 4,   JNK↓, 4,   JNK↑, 5,   p‑JNK↓, 1,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 13,   MAPK↑, 9,   MAPK↝, 1,   p‑MAPK↑, 1,   MEK↓, 1,   p‑MEK↓, 1,   MKK4↓, 1,   MKP1↝, 1,   mTOR↓, 29,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 4,   mTORC2↓, 1,   p70S6↓, 1,   P70S6K↓, 3,   P70S6K↑, 1,   p‑P70S6K↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 39,   PI3K↑, 1,   p‑PI3K↓, 1,   PKCδ↓, 3,   PTEN↓, 2,   PTEN↑, 6,   Raf↓, 2,   e-Raf↓, 1,   RAS↓, 4,   RIP1↓, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 6,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 22,   p‑STAT3↓, 5,   p‑STAT6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF3↑, 1,   ATF4↑, 7,   ATFs↑, 1,   cJun↓, 2,   p‑cJun↑, 1,   cMyc↓, 11,   cMyc↑, 1,   DLEU1↓, 1,   DNMT1↑, 1,   DNMTs↓, 1,   FOXM1↓, 1,   FOXO1↑, 2,   FOXO3↓, 1,   FOXO3↑, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   H3↓, 2,   H3↑, 1,   H4↓, 1,   HATs↑, 1,   HDAC↓, 6,   HDAC1↓, 2,   HDAC2↓, 2,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-10b-5p↓, 1,   miR-182-5p↓, 1,   miR-200b↑, 1,   miR-21↓, 2,   miR-22↑, 1,   miR-34a↓, 2,   miR-592↑, 1,   Myc↓, 1,   OCT4↓, 4,   other?, 1,   other↓, 2,   other↑, 5,   other↝, 11,   other∅, 1,   PhotoS↑, 1,   SOX2↓, 3,   TCF-4↓, 1,   tumCV↓, 26,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 7,   eIF2α↑, 4,   p‑eIF2α↑, 3,   ER Stress↑, 21,   Erlin1↑, 1,   GRP78/BiP↑, 6,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 5,   HSPs↓, 1,   IRE1↑, 1,   PERK↑, 5,   p‑PERK↑, 1,   UPR↑, 8,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   autoF↓, 1,   autolysosome↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 8,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 2,   LC3s↑, 1,   lysoMP↑, 2,   lysosome↝, 1,   MitoP↑, 1,   p62↓, 2,   p62↑, 1,   p‑p62↑, 1,   TumAuto↑, 16,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 37,   hTERT/TERT↓, 3,   P53↓, 3,   P53↑, 47,   P53↝, 1,   PARP↑, 7,   cl‑PARP↓, 1,   cl‑PARP↑, 16,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 16,   Telomerase↓, 2,   TOP1↓, 4,   TOP2↓, 1,   TOP2↑, 1,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 9,   CDK1↑, 3,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK2↓, 13,   CDK2↑, 1,   CDK4↓, 15,   CDK4↑, 2,   CDK6↓, 3,   CDK6↑, 1,   CDK7↓, 1,   CHK1↓, 2,   CHK1↝, 1,   Chk2↓, 1,   Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 4,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 14,   CycB/CCNB1↑, 2,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 19,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 9,   cycE/CCNE↑, 1,   E2Fs↓, 2,   Ki-67↓, 12,   mitA↑, 1,   P21↓, 2,   P21↑, 20,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 4,   pRB↑, 1,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   TumCCA↓, 1,   TumCCA↑, 85,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 2,   ALDH1A1↓, 1,   BMP7/OP1↓, 1,   BMPs↑, 1,   CD133↓, 1,   CD24↓, 1,   CD34↓, 1,   cFos↓, 2,   cFos↑, 1,   CSCs↓, 8,   Diff↑, 2,   FGF↓, 2,   FOSL1↑, 1,   Gli1↓, 1,   HMGCR↓, 1,   IGF-1↓, 2,   Ki-67↓, 12,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 2,   NOTCH↓, 2,   NOTCH↑, 1,   NOTCH1↓, 8,   NOTCH1↑, 2,   Piezo1↑, 2,   Shh↓, 1,   TumCG↓, 37,   TumCP↓, 73,   TumCP↑, 2,   TumCP⇅, 1,   tyrosinase↓, 1,   Wnt↓, 12,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 5,   AP-1↑, 1,   ASAP2↓, 1,   AXL↓, 2,   BACH1↑, 1,   Ca+2↓, 3,   Ca+2↑, 12,   i-Ca+2↑, 2,   Cdc42↓, 1,   Cofilin↓, 1,   COL1↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 13,   EMT↓, 23,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 2,   p‑FAK↓, 2,   fascin↓, 2,   Fibronectin↓, 2,   ITGB1↓, 1,   KRAS↓, 1,   MALAT1↓, 1,   MET↓, 2,   p‑MET↓, 2,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 27,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 30,   MMP9↑, 2,   MMPs↓, 20,   N-cadherin↓, 12,   PDGF↓, 2,   PGF↓, 1,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 2,   Rho↝, 1,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 5,   SMAD2↓, 1,   Snail↓, 9,   T-cadherin↑, 1,   TET1↑, 2,   TGF-β↓, 2,   TIMP1↓, 1,   TIMP1↑, 6,   TIMP2↑, 7,   TIMP3↑, 1,   TRIB3↑, 1,   TumCA↓, 1,   TumCI↓, 29,   TumCI↑, 1,   TumCMig↓, 30,   TumCMig↑, 1,   TumMeta↓, 28,   TumMeta↑, 3,   TumPF↓, 1,   Twist↓, 5,   Tyro3↓, 1,   uPA↓, 7,   uPAR↓, 1,   Vim↓, 12,   Vim↑, 1,   Zeb1↓, 1,   ZEB2↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 17,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 40,   angioG↑, 1,   CD31/PECAM-1↓, 2,   EGR4↓, 1,   HIF-1↓, 2,   HIF-1↑, 1,   Hif1a↓, 19,   Hypoxia↓, 1,   LOX1↓, 2,   NO↓, 3,   NO↑, 4,   REL↑, 1,   VCAM-1↓, 2,   VEGF↓, 36,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CellMemb↑, 1,   CLDN1↓, 2,   CLDN2↓, 1,   EPR↑, 3,   GLUT1↓, 4,   MMP↓, 52,   MMP↑, 1,   MPT↑, 3,   SLC12A5↓, 1,   TRPM7↓, 1,   TRPV1↝, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   CD44↓, 5,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 36,   COX2/PTGS2↑, 3,   COX2/PTGS2↝, 1,   CXCc↓, 1,   CXCR2↓, 1,   CXCR3↓, 1,   CXCR4↓, 5,   DR4↑, 5,   Eos↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   HLA↑, 1,   HMGB1↓, 1,   ICAM-1↓, 3,   IFN-γ↓, 4,   IFN-γ↑, 2,   Igs↓, 1,   Igs↑, 1,   IL1↓, 2,   IL10↓, 2,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 9,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 4,   IL4↓, 2,   IL6↓, 13,   IL8↓, 4,   Imm↑, 11,   Imm↝, 1,   Inflam↓, 11,   LRIG1↑, 1,   pol-M1↑, 2,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   MDSCs↓, 1,   MIP2↓, 1,   Neut↑, 1,   NF-kB↓, 50,   NF-kB↑, 4,   p‑NF-kB↓, 1,   NK cell↑, 6,   NLRP3↓, 2,   NLRP3↑, 1,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 6,   PGE2↓, 6,   PSA↓, 3,   T-Cell↑, 1,   Th1 response↑, 1,   Th17↑, 1,   TLR1↑, 1,   TLR4↓, 3,   TNF-α↓, 15,   TNF-α↑, 2,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 6,   AR↑, 1,   CYP24A1↓, 1,   ER-α36↓, 3,   ER(estro)↓, 2,   ER(estro)↑, 1,   ERα/ESR1↓, 1,   FGF21↓, 1,   PPARα↓, 2,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 12,   BioAv↑, 15,   BioAv↝, 4,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 73,   ChemoSen↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 2,   DDS↑, 2,   Dose?, 2,   Dose↑, 6,   Dose↝, 20,   Dose∅, 2,   eff↓, 25,   eff↑, 43,   eff↝, 5,   Half-Life↓, 4,   Half-Life↑, 1,   MDR1↓, 4,   P-gp/ABCB1↓, 6,   P-gp/ABCB1↑, 1,   P450↓, 1,   RadioS↑, 22,   selectivity↑, 40,   Synergy?, 1,   Synergy↑, 40,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 2,   ALAT↓, 5,   ALP↓, 1,   AR↓, 6,   AR↑, 1,   ascitic↓, 1,   AST↓, 3,   BG↓, 1,   BP↓, 1,   BUN↓, 1,   CEA↓, 2,   CIT↓, 1,   creat↓, 2,   CRP↓, 1,   E6↓, 4,   E7↓, 4,   EGFR↓, 9,   EGFR↑, 2,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   Ferritin↓, 3,   FOXM1↓, 1,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 13,   KeyT↑, 1,   KRAS↓, 1,   LDH↓, 4,   LDH↑, 2,   Myc↓, 1,   NSE↓, 1,   PD-L1↓, 6,   PSA↓, 3,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 32,   antiNeop↑, 1,   AntiTum↑, 12,   cachexia↓, 2,   cardioP↑, 8,   chemoP↑, 23,   chemoPv↑, 8,   ChemoSideEff↓, 1,   cognitive↑, 3,   hepatoP↑, 11,   memory↑, 1,   neuroP↑, 4,   OS?, 1,   OS↑, 5,   Pain↓, 2,   Pin1↓, 1,   QoL↑, 3,   radioP↑, 6,   Remission↑, 1,   RenoP↑, 6,   Risk↓, 7,   toxicity↓, 7,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol?, 1,   TumVol↓, 7,   TumW↓, 4,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiP↑, 1,   Bacteria↓, 1,   GutMicro↑, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 8,  
Total Targets: 749

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6,   antiOx↑, 150,   ARE↑, 3,   Bil↓, 2,   Bil↑, 2,   Catalase↓, 3,   Catalase↑, 88,   Fenton↓, 4,   GCLC↑, 2,   GCLM↑, 2,   GPx↓, 2,   GPx↑, 61,   GPx1↑, 3,   GPx4↓, 3,   GPx4↑, 3,   GPx4∅, 1,   GSH↓, 3,   GSH↑, 98,   GSH/GSSG↑, 1,   GSR↓, 1,   GSR↑, 19,   GSSG↓, 3,   GSTs↓, 3,   GSTs↑, 24,   H2O2↓, 11,   HDL↓, 1,   HDL↑, 6,   HDL∅, 1,   HNE↓, 1,   HO-1?, 1,   HO-1↓, 3,   HO-1↑, 49,   HO-1↝, 1,   HO-1∅, 1,   Iron↓, 2,   Iron↝, 1,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   lipid-P?, 3,   lipid-P↓, 260,   lipid-P↑, 7,   mt-lipid-P↓, 1,   MDA↓, 59,   MDA↑, 1,   MPO↓, 7,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 3,   NQO1↑, 11,   Nrf1↑, 2,   NRF2↓, 4,   NRF2↑, 79,   NRF2∅, 1,   ONOO↓, 1,   Prx↑, 2,   RNS↓, 3,   ROS?, 2,   ROS↓, 210,   ROS↑, 6,   mt-ROS↓, 2,   selenoP↑, 2,   SOD?, 1,   SOD↓, 3,   SOD↑, 126,   mt-SOD↑, 1,   SOD1↓, 1,   SOD1↑, 3,   SOD2↑, 2,   TAC↑, 14,   TBARS↓, 5,   Thiols↑, 2,   TOS↓, 3,   Trx↑, 2,   UCPs↑, 1,   uricA↓, 2,   VitC↑, 7,   VitE↓, 1,   VitE↑, 3,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 18,   IronCh↝, 1,   Mets↝, 1,   NCOA4↝, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compIV↑, 2,   DRP1/DNM1L↑, 1,   ETC↑, 1,   FIS1↓, 2,   MFN1↓, 1,   MFN2↓, 1,   mitResp↑, 3,   mtDam↓, 11,   OCR↑, 1,   OPA1↓, 1,   PGC-1α↓, 1,   PGC-1α↑, 3,   PINK1↑, 1,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 8,   ACC↑, 1,   Acetyl-CoA↑, 3,   ACSL4↓, 2,   ACSL4∅, 1,   adiP↑, 2,   ALAT↓, 34,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 16,   p‑AMPK↑, 1,   ATP↓, 1,   ATP↑, 15,   ATP∅, 1,   mt-ATP↑, 1,   Buty↑, 1,   CPT1A↑, 1,   CRM↑, 1,   FASN↓, 1,   FFA/NEFA↓, 1,   G6PD↑, 1,   glucose↓, 3,   glucose↑, 1,   glucose↝, 2,   GlucoseCon↑, 5,   GSK‐3β↓, 14,   GSK‐3β↑, 1,   H2S↑, 2,   HK2↑, 1,   HMG-CoA↓, 1,   IDH1↑, 1,   LDL↓, 18,   lipidLev↓, 1,   NAD↓, 1,   NADH:NAD↑, 1,   NADPH↓, 5,   NADPH↑, 3,   PGC1A↑, 1,   PLA2↓, 1,   PONs↑, 1,   SCD1↓, 1,   SCFAs↑, 2,   SIRT1↑, 18,   SREBP1/SREBF1↓, 2,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 23,   ASC↓, 1,   BAX↓, 17,   BAX↑, 2,   Bax:Bcl2↓, 1,   Bcl-2↓, 4,   Bcl-2↑, 11,   Bcl-xL↑, 1,   Casp↓, 2,   cl‑Casp1↓, 1,   Casp3?, 1,   Casp3↓, 25,   Casp3↑, 1,   cl‑Casp3↓, 2,   proCasp3↓, 1,   Casp9↓, 11,   Cyt‑c↓, 6,   Cyt‑c∅, 1,   Fas↓, 2,   Ferroptosis↓, 9,   Ferroptosis↑, 2,   GSDMD↓, 1,   iNOS↓, 35,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 6,   p38↑, 1,   p‑p38↓, 1,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 6,   Akt↑, 8,   p‑Akt↓, 1,   p‑Akt↑, 1,   Akt2↓, 1,   CREB↑, 3,   p‑CREB↑, 2,   EGFR↓, 1,   ERK↓, 5,   ERK↑, 1,   p‑ERK↓, 2,   IKKα↓, 2,   IκB?, 1,   IκB↓, 1,   IκB↑, 1,   JAK↓, 1,   JAK2↓, 2,   JAK2↑, 1,   JNK↓, 6,   JNK↑, 2,   p‑JNK↓, 3,   MAPK↓, 10,   MAPK↑, 4,   MAPK↝, 1,   p‑MAPK?, 1,   p‑MAPK↓, 1,   mTOR↓, 2,   mTOR↑, 3,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 8,   PKA↑, 1,   PKCδ↓, 1,   PKCδ↑, 1,   PP2A↑, 1,   STAT↓, 1,   STAT3↓, 5,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF4↓, 2,   cJun↓, 2,   cMyc↓, 1,   FOXO↑, 2,   FOXO3↑, 1,   HDAC↓, 1,   OCT4↓, 1,   other?, 2,   other↓, 7,   other↑, 10,   other↝, 17,   other∅, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 7,   GRP78/BiP↓, 4,   GRP78/BiP↑, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSPs↓, 1,   IRE1↓, 1,   PERK↓, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 1,   LC3B↑, 1,   LC3II↓, 1,   MitoP↑, 4,   p62↓, 2,   p62↑, 1,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 14,   DNArepair↑, 1,   P53↓, 1,   P53↑, 1,   PCNA↑, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   cycD1/CCND1↓, 1,   GADD34↓, 1,   P21↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↓, 1,   Diff↑, 1,   Diff↝, 1,   IGF-1↑, 2,   IGFBP1↑, 1,   neuroG↑, 4,   TumCP↓, 2,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 11,   AP-1↓, 3,   ATPase↑, 1,   Ca+2↓, 9,   Ca+2↑, 1,   Ca+2↝, 2,   Cartilage↑, 3,   COL1↓, 2,   COL1↑, 1,   Fibrosis↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 6,   MMPs↓, 2,   MUC1↑, 1,   N-cadherin↑, 1,   Na+↑, 1,   PDGF↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TGF-β1↓, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 1,   TXNIP↓, 1,   Tyro3↓, 1,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 4,   CD31/PECAM-1↑, 1,   E-sel↓, 2,   Endoglin↑, 1,   eNOS↓, 1,   p‑eNOS↑, 1,   LOX1↓, 1,   NO↓, 21,   NO↑, 1,   VCAM-1↓, 6,   VEGF↓, 2,   VEGF↑, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 4,   BBB↑, 28,   BBB↝, 3,   BBB∅, 2,   GastroP↑, 7,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 3,   MMP↓, 3,   MMP↑, 18,   MUC19↓, 1,   MUC2↓, 1,   MUC5AC↓, 1,   Na+↑, 1,   OATPs↓, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 3,   TRPA1↑, 1,   TRPM7↓, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 1,   CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 4,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 52,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 7,   IFN-γ↓, 9,   IFN-γ↑, 2,   IL1↓, 3,   IL10↓, 5,   IL10↑, 7,   IL12↓, 1,   IL17↓, 6,   IL18↓, 1,   IL1β↓, 52,   IL2↓, 4,   IL23↓, 2,   IL33↓, 1,   IL4↓, 7,   IL4↑, 1,   IL5↓, 1,   IL6↓, 53,   IL6↑, 2,   IL8↓, 8,   IL8↑, 1,   Imm↓, 1,   Imm↑, 10,   INF-γ↓, 1,   Inflam?, 1,   Inflam↓, 154,   Inflam↑, 3,   IRF3↓, 2,   M2 MC↑, 1,   MCP1/CCL2↓, 7,   MyD88↓, 2,   NeuroI↓, 6,   NF-kB↓, 78,   NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 17,   p65↓, 1,   PGE2↓, 18,   RAGE↓, 1,   RANTES↓, 1,   TLR1↓, 2,   TLR2↓, 3,   TLR4↓, 11,   TLR4↑, 1,   TNF-α↓, 78,   TNF-α↑, 1,   Treg lymp↝, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 5,   Ach↑, 9,   AChE↓, 49,   AChE↑, 1,   ADAM10↑, 1,   BChE↓, 9,   BDNF↓, 2,   BDNF↑, 23,   ChAT↑, 9,   ChE↓, 1,   DA↑, 1,   GABA↑, 2,   GABA↝, 1,   GDNF↑, 1,   MAOA↓, 5,   MAOA↑, 1,   MAOA↝, 1,   MAOB↓, 3,   monoA↓, 1,   monoA↑, 1,   NGF↑, 3,   PSD95↑, 5,   RELN↑, 1,   SNAP25↑, 3,   TPH1↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 4,   Aβ↓, 55,   Aβ42↓, 3,   BACE/β-secretase↓, 16,   PSEN1/PS1↓, 1,   tau↓, 11,   p‑tau↓, 13,   XO↓, 1,   XO↝, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

cortisol↓, 1,   CYP19↓, 1,   END↑, 1,   ER(estro)↓, 1,   GLP-1R↑, 1,   GR↓, 1,   GR↑, 4,   PPARα↑, 2,   PPARγ↓, 1,   PPARγ↑, 8,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 32,   BioAv↑, 57,   BioAv⇅, 1,   BioAv↝, 13,   BioEnh↑, 1,   ChemoSen↑, 2,   CompStab↑, 2,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose↝, 21,   eff↓, 1,   eff↑, 32,   eff↝, 2,   GSTA1↓, 1,   Half-Life↓, 4,   Half-Life↑, 3,   Half-Life↝, 14,   P-gp/ABCB1↓, 1,   P450↓, 2,   P450↑, 1,   Synergy↑, 18,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 34,   ALB↝, 1,   ALP↓, 12,   AST↓, 35,   BG↓, 3,   Bil↓, 2,   Bil↑, 2,   BloodF↑, 4,   BMD↑, 3,   BP↓, 11,   BP↝, 1,   BP∅, 1,   BUN↓, 4,   CEA↓, 1,   CK/CK-MB↓, 1,   creat↓, 9,   CRP↓, 9,   EGFR↓, 1,   hs-CRP↓, 1,   IL6↓, 53,   IL6↑, 2,   LDH↓, 14,   LDH↑, 1,   NOS2↓, 4,   RAGE↓, 1,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 5,   Urea↓, 3,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 9,   antiAll↑, 9,   AntiArt↑, 5,   AntiCan↑, 14,   antiCG↑, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 21,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 1,   AntiTum↑, 4,   Bone Healing↑, 1,   cardioP↑, 63,   CardioT↓, 1,   chemoP↑, 7,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 64,   cognitive∅, 2,   diuretic↑, 3,   hepatoP↓, 1,   hepatoP↑, 63,   Learn↑, 7,   memory?, 1,   memory↓, 1,   memory↑, 66,   memory∅, 1,   Mood↑, 1,   motorD↓, 1,   motorD↑, 8,   Mucositis↓, 2,   neuroP↑, 118,   NP/CIPN↓, 1,   Obesity↓, 7,   OS↑, 3,   Pain↓, 4,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 26,   Risk↓, 3,   Sleep↑, 2,   Strength↑, 3,   Stress↓, 1,   Stroke↓, 7,   toxicity↓, 36,   toxicity↑, 2,   toxicity↝, 10,   toxicity∅, 5,   Weight↓, 2,   Weight↑, 1,   Weight∅, 2,   Wound Healing↑, 8,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 8,   AntiFungal↑, 8,   AntiP↑, 1,   AntiViral↑, 8,   Bacteria↓, 17,   Diar↓, 2,   GutMicro↑, 22,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↑, 2,   Ingr↝, 10,  
Total Targets: 572

Scientific Paper Hit Count for: lipid-P, lipid peroxidation
17 Curcumin
14 Thymoquinone
13 Quercetin
12 Silymarin (Milk Thistle) silibinin
11 Luteolin
11 Resveratrol
10 Silver-NanoParticles
10 Alpha-Lipoic-Acid
9 Eugenol
7 Artemisinin
7 Chrysin
7 Ferulic acid
7 Lycopene
7 Rosmarinic acid
7 Urolithin
6 Ashwagandha(Withaferin A)
6 Berberine
6 Carvacrol
6 Crocetin
6 Copper and Cu NanoParticles
6 Cisplatin
6 Shikonin
5 doxorubicin
5 Cinnamon
5 Matrine
5 Piperlongumine
5 Selenium NanoParticles
5 Selenite (Sodium)
4 Vitamin C (Ascorbic Acid)
4 Bacopa monnieri
4 Boron
4 Boswellia (frankincense)
4 Caffeic acid
4 Propolis -bee glue
4 Centella asiatica / Gotu kola → asiaticoside
4 Chemotherapy
4 Radiotherapy/Radiation
4 isoquercitrin
4 Phenethyl isothiocyanate
4 Licochalcone A
3 Allicin (mainly Garlic)
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Beta-Caryophyllene
3 α-Bisabolol / Chamomile oil
3 chitosan
3 Coenzyme Q10
3 Selenium
3 Docosahexaenoic Acid
3 Dandelion Root
3 EGCG (Epigallocatechin Gallate)
3 erastin
3 Fisetin
3 Shilajit/Fulvic Acid
3 γ-linolenic acid (Borage Oil)
3 Hydrogen Gas
3 Juglone
3 Melatonin
3 Moringa oleifera
3 Pterostilbene
3 salinomycin
2 1,8-Cineole
2 alpha Linolenic acid
2 Astaxanthin
2 Baicalein
2 Biochanin A
2 beta-carotene(VitA)
2 buckwheat sprouts
2 Capsaicin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Carnosine
2 Citicoline, CDP-Choline
2 Citric Acid
2 Vitamin E
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Spirulina(Arthrospira/Limnospira)
2 Disulfiram
2 Emodin
2 Flaxseed/Linseed
2 phytic acid, Inositol hexakisphosphate
2 Flaxseed Oil
2 Ginkgo biloba
2 Ginkgetin
2 Graviola
2 Hyperoside
2 Inositol
2 Isoliquiritigenin
2 Sulforaphane (mainly Broccoli)
2 Kaempferol
2 Licorice
2 Linalool
2 Magnetic Fields
2 Mangiferin
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Piperine
2 Rutin
2 Vitexin
1 Astragalus
1 Glucose
1 Apigenin (mainly Parsley)
1 Atorvastatin
1 Aloe anthraquinones
1 Betulinic acid
1 Bromelain
1 Bruteridin(bergamot juice)
1 Chlorogenic acid
1 Chlorophyllin
1 Chocolate
1 Cichoric acid / Chicoric acid
1 methotrexate
1 immunotherapy
1 Carica papaya leaf extract
1 Cranberry
1 Chlorella (Chlorella vulgaris)
1 Cynaropicrin
1 Diclofenac
1 diet Fermented Foods
1 diet Ketogenic
1 Oxygen, Hyperbaric
1 D-limonene
1 eicosapentaenoic acid
1 ferumoxytol
1 Formononetin
1 Fucoidan
1 Gallic acid
1 Gambogic Acid
1 Ginkgolide B
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Honokiol
1 HydroxyTyrosol
1 Inulin Prebiotic
1 Isorhamnetin
1 isoflavones
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Lactobacillus
1 Lapachol
1 SDG/lignans
1 Methylene blue
1 MBE, Maqui berry
1 Mung Bean Sprouts
1 Methyl Jasmonate
1 methylseleninic acid
1 Magnetic Field Rotating
1 Lemon Balm/Melissa officinalis
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Naringin
1 Patchouli Oil (Pogostemon cablin)
1 Phosphatidylserine
1 Sulfasalazine
1 Shankhpushpi
1 Spermidine
1 Taurine
1 5-fluorouracil
1 Turmerones
1 Vitamin B5,Pantothenic Acid
1 VitK3,menadione
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:453  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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