BioAv Cancer Research Results

BioAv, bioavailability: Click to Expand ⟱
Source:
Type: measurement
Bioavailability (usually in %) absorbed by the body.
Scientific Papers found: Click to Expand⟱
1806- NarG,    Naringin: Nanotechnological Strategies for Potential Pharmaceutical Applications
- Review, NA, NA
Inflam↓, antiOx↓, AntiCan↑, BioAv↓, BioAv↓, BioAv↑, INF-γ↓, IL6↓, TNF-α↓, IL10↑, CRP↓,
1805- NarG,    Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota
- in-vitro, Ovarian, A2780S - in-vivo, NA, NA
TumCP↓, TumCMig↓, PI3K↓, TumVol↓, TumW↓, BioAv↑, GutMicro↑, Dose∅, eff↑, EGFR↓, cycD1/CCND1↓, toxicity∅,
1804- NarG,    Beneficial effects of citrus flavanones naringin and naringenin and their food sources on lipid metabolism: An update on bioavailability, pharmacokinetics, and mechanisms
- Review, NA, NA
GutMicro↝, BioAv↝,
1799- NarG,    Naringenin as potent anticancer phytocompound in breast carcinoma: from mechanistic approach to nanoformulations based therapeutics
- Review, NA, NA
TumCCA↑, BioAv↑, Half-Life∅, TNF-α↓, Casp8↑, BAX↑, Bak↑, EGF↓, mTOR↓, PI3K↓, ERK↓, Akt↓, NF-kB↓, VEGF↓, angioG↓, antiOx↑, EMT↓, OS↑, MAPK↓, ChemoSen↑, MMP9↓, MMP2↓, ROS↑, ROS↑, GSH↓, Casp3↑, ROS↑,
5253- NCL,    Niclosamide: Beyond an antihelminthic drug
- Review, Var, NA
TumCP↓, Apoptosis↑, EMT↓, β-catenin/ZEB1↓, TumCG↓, toxicity↓, Wnt↓, LRP6↓, eff↑, DR5↑, mTORC1↓, pH↓, CSCs↓, IL6↓, JAK1↓, STAT3↓, ChemoSen↑, TumCG↓, tumCV↓, NOTCH↓, NF-kB↓, EGFR↓, ROS↑, RadioS↑, cFos↓, cJun↓, E2Fs↓, cMyc↓, Half-Life↓, BioAv↝,
5254- NCL,    The magic bullet: Niclosamide
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, RAS↓, STAT3↓, NOTCH↓, E2Fs↓, mTOR↓, eff↑, PD-1↓, PD-L1↓, BioAv↝, toxicity↓, BioAv↑, ETC↑, NADH:NAD↓, TCA↑, Warburg↓, Diff↑, AMPK↑, P53↑, PP2A↑, HIF-1↓, KRAS↓, Myc↓, RadioS↑, ChemoSen↑, Dose↝, Dose↑,
5255- NCL,    Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, double-blind, placebo-controlled trial
- Trial, Nor, NA
BioAv↝, Dose↝, toxicity↓, BioAv↑, BioAv↝,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
4631- OLE,    Evidence to Support the Anti-Cancer Effect of Olive Leaf Extract and Future Directions
- Review, Var, NA
TumCP↓, *BioAv↑, *ROS↓, *NO↓, NF-kB↓, COX2↓, IL6↓, IL8↓, IL1β↓,
4646- OLEC,    Oleocanthal as a Multifunctional Anti-Cancer Agent: Mechanistic Insights, Advanced Delivery Strategies, and Synergies for Precision Oncology
- Review, Var, NA
BioAv↓, *Inflam↓, *antiOx↓, cMET↓, STAT3↓, TNF-α↓, COX2↓, EMT↓, angioG↓, *GutMicro↝, eff↑,
1814- Oxy,    Hyperbaric oxygen therapy for malignancy: a review
- Review, Var, NA
ROS↑, SOD↑, OS↑, ChemoSen↑, RadioS↑, BioAv↑,
2052- PB,    Lipid-regulating properties of butyric acid and 4-phenylbutyric acid: Molecular mechanisms and therapeutic applications
- Review, NA, NA
*HDAC↓, *Half-Life↑, *Half-Life↑, *lipoGen↓, *ER Stress↓, *FAO↑, *ROS↓, *BioAv↑,
2026- PB,    Oral sodium phenylbutyrate in patients with recurrent malignant gliomas: A dose escalation and pharmacologic study
- Trial, GBM, NA
Dose↝, Dose↑, Dose↝, OS↑, HDAC↓, TumCCA↑, P21↑, other↝, BioAv↑, eff↑,
2038- PB,    A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies
- Trial, Var, NA
Dose∅, *toxicity↝, BioAv↑, SD↑,
2045- PB,    Phenylbutyrate—a pan-HDAC inhibitor—suppresses proliferation of glioblastoma LN-229 cell line
- in-vitro, GBM, LN229 - in-vitro, GBM, LN-18
HDAC↓, TumCG↓, TumCCA↑, P21↑, Bcl-2↓, Bcl-xL↓, BioAv↑,
1666- PBG,    Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
- Review, Var, NA
ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2↑, ER(estro)↓, cycA1/CCNA1↓, CycB/CCNB1↓, CDK2↓, P21↑, p27↑, hTERT/TERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
3247- PBG,    Bioavailability and In Vivo Antioxidant Activity of a Standardized Polyphenol Mixture Extracted from Brown Propolis
- Review, NA, NA
Half-Life↝, BioAv↓, Half-Life↝, BioAv↓,
3248- PBG,    Propolis as a promising functional ingredient: A comprehensive review on extraction, bioactive properties, bioavailability, and industrial applications
- Review, NA, NA
*BioAv↓, *Half-Life↓,
3251- PBG,    The Antioxidant and Anti-Inflammatory Effects of Flavonoids from Propolis via Nrf2 and NF-κB Pathways
- Review, AD, NA - Review, Diabetic, NA - Review, Var, NA - in-vitro, Nor, H9c2
*antiOx↑, *Inflam↓, *ROS↓, *SOD↑, *Catalase↑, *HO-1↑, *NO↓, *NOS2↓, *NF-kB↓, *NRF2↑, *hepatoP↑, *MDA↓, *mtDam↓, *GSH↑, *p65↓, *TNF-α↓, *IL1β↓, *NRF2↑, *NRF2↓, *ROS⇅, *BioAv↓, *BioAv↑,
4935- PEITC,    Phenethyl Isothiocyanate Suppresses Inhibitor of Apoptosis Family Protein Expression in Prostate Cancer Cells in Culture and In Vivo
- in-vivo, Pca, LNCaP - in-vivo, Pca, PC3
Apoptosis↑, XIAP↓, survivin↓, *BioAv↑, tumCV↓, eff↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
4924- PEITC,    Nutri-PEITC Jelly Significantly Improves Progression-Free Survival and Quality of Life in Patients with Advanced Oral and Oropharyngeal Cancer: A Blinded Randomized Placebo-Controlled Trial
- Trial, Oral, NA
QoL↑, P53↑, OS↑, Cyt‑c↝, other↝, ROS↑, selectivity↑, P21↑, TumCCA↑, Dose↝, BioAv↑, Weight↑, chemoP↑,
4920- PEITC,  Cisplatin,    PEITC restores chemosensitivity in cisplatin-resistant non-small cell lung cancer by targeting c-Myc/miR-424-5p
- vitro+vivo, NSCLC, A549
TumCG↓, ChemoSen↑, cMyc↓, PI3K↓, Akt↓, mTOR↓, BioAv↝, tumCV↓, ChemoSen↑,
4918- PEITC,    Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
- Review, Var, NA
Apoptosis↑, TumCP↓, angioG↓, TumMeta↓, NF-kB↓, Akt↓, MAPK↓, *BioAv↓, ROS↑, lipid-P↑, AIF↑, Cyt‑c↑, DR4↑, DR5↑, TumCCA↑, JAK↓, STAT3↓, MMP2↓, MMP9↓, PKCδ↓, Hif1a↓, JNK↓, Mcl-1↓, COX2↓, MMP↓, Casp3↑, ChemoSen↑, *BioAv↓, Half-Life↓,
4927- PEITC,    Targeting ferroptosis in osteosarcoma
- Review, OS, NA
AntiCan↑, BioAv↑, Ferroptosis↑, TfR1/CD71↑, Iron↑, ROS↑, MDA↑, lipid-P↑, GPx4↓,
4938- PEITC,    Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers
- Trial, Nor, NA
*Risk↑, *P450↓, *BioAv↑, *BioAv↑, *BioAv↑, *Dose↝, Dose↝,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *eff↑, *BioAv↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑,
3595- PI,    Black pepper and health claims: a comprehensive treatise
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *chemoP↑, TumCG↓, *cognitive↑, *MMPs↓, *PGE2↓, *AP-1↓, *5LO↓, *COX1↓, *other↑, *other↑, *other↑, *SOD↑, *Catalase↑, *GSTs↑, *GSR↑, *other↑, *Weight↓, *BioEnh↑, *BioAv↑, *eff↑, *CYP3A2↓, *neuroP↑, *BP↓, *other↑,
1948- PL,  BNL,    Natural borneol serves as an adjuvant agent to promote the cellular uptake of piperlongumine for improving its antiglioma efficacy
- in-vitro, GBM, NA
selectivity↑, ROS↑, BioAv↓, BioAv↑, Apoptosis↑, TumCCA↑, eff↑,
2649- PL,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
AntiCan↑, ROS↑, GSH↓, TrxR↓, Trx↓, Apoptosis↑, TumCCA↑, ER Stress↑, DNAdam↑, ChemoSen↑, BioAv↓,
2966- PL,    A strategy to improve the solubility and bioavailability of the insoluble drug piperlongumine through albumin nanoparticles
- in-vitro, LiverDam, NA
*Half-Life↑, *BioAv↑, eff↑, ROS↑,
2968- PL,  Chit,    Preparation of piperlongumine-loaded chitosan nanoparticles for safe and efficient cancer therapy
- in-vitro, GC, AGS
eff↑, Dose↝, ROS↑, BioAv↑,
2967- PL,    Piperlongumine and its derivatives against cancer: A recent update and future prospective
- Review, Var, NA
BioAv↓, BioAv↑,
2964- PL,    Preformulation Studies on Piperlongumine
- Analysis, Nor, NA
*BioAv↓, *BioAv↑, *other↝, *eff↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp↓, MDR1↓, MRP1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2962- PL,    Synthesis of Piperlongumine Analogues and Discovery of Nuclear Factor Erythroid 2‑Related Factor 2 (Nrf2) Activators as Potential Neuroprotective Agents
- in-vitro, Nor, PC12
*GSH↑, *NQO1↑, *Trx↑, *TrxR↑, *NRF2↑, *NRF2⇅, *eff↑, *BioAv↑, *ROS↓,
4968- PSO,    Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer
- in-vitro, Cerv, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiDiabetic↑, *Bacteria↓, AntiTum↑, CSCs↓, ROS↑, TumAuto↑, Apoptosis↑, ChemoSen↑, RadioS↑, BioAv↓, *cardioP↑, *ROS↓, *LDH↓, TumCP↓, TRAIL⇅, TumCMig↓, EMT↓, NF-kB↓, P53↑, Casp3↑, NOTCH↓, CSCs↓, angioG↓, VEGF↓, Ki-67↓, CD31↓, TRAILR↑, MMP↓, BioAv↓, BioAv↑,
5157- PTL,    An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
- vitro+vivo, AML, NA
CSCs↓, selectivity↑, BioAv↓, BioAv↑, ROS↑, NF-kB↓, P53↑,
3925- PTS,    Analysis of Safety from a Human Clinical Trial with Pterostilbene
- Trial, NA, NA
*toxicity↓, *Half-Life↑, *BioAv↑,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
3929- PTS,    New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects
- Review, Var, NA - Review, Arthritis, NA
*NRF2↑, *BioAv↑, *ROS↓, *Inflam↓, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *hepatoP↑, *neuroP↑, *iNOS↓, *COX2↓, TumMeta↓, SOD2↓, ROS↑, TumCI↓, TumCG↓, HDAC1↓, PTEN↑, BP↓, *GutMicro↑,
3927- PTS,    Effects of Pterostilbene on Cardiovascular Health and Disease
- Review, AD, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *BioAv↑, *toxicity↓, *NADPH↓, *ROS↓, *Catalase↑, *GSH↑, *SOD↑, *TNF-α↓, *IL1β↓, *IL4↓, *MMPs↓, *COX2↓, *MAPK↝, *NF-kB↓, *IL8↓, *MCP1↓, *E-sel↓, *lipid-P↓, *NRF2↑, *PPARα↑, *LDL↓, other↓,
3923- PTS,    Pterostilbene Supplement Benefits: Longevity Miracle or Hoax
- Review, AD, NA
*BioAv↑, *Half-Life↑, *BBB↑, *BP↓, *cognitive↑,
3922- PTS,    Pterostilbene attenuates amyloid-β induced neurotoxicity with regulating PDE4A-CREB-BDNF pathway
- in-vivo, AD, NA
*BioAv↑, *BBB↑, *memory↑, *p‑CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
5034- PTS,    Pterostilbene in Cancer Therapy
- Review, Var, NA
BioAv↓, Half-Life↓, iNOS↓, Apoptosis↑, STAT3↓, Akt↓, mTOR↓, NF-kB↓, NRF2↓, ChemoSen↑, BBB↑,
4693- PTS,    Pterostilbene in the treatment of inflammatory and oncological diseases
BioAv↑, *Inflam↓, *antiOx↑, AntiTum↑, BBB↑, Half-Life↝, *ROS↓, *NRF2↑, *NQO1↑, *HO-1↑, PTEN↑, miR-19b↓, TumCCA↑, ER Stress↑, PERK↑, ATF4↑, CHOP↑, Ca+2↝, EMT↓, NF-kB↓, Twist↓, Vim↓, E-cadherin↑, ChemoSen↑, toxicity∅, toxicity↝,
4702- PTS,    Pterostilbene Inhibits Pancreatic Cancer In Vitro
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1
tumCV↓, TumCG↓, BioAv↑,
4697- PTS,    Pterostilbene and cancer: current review
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumMeta↑, toxicity↓, BioAv↑,
4695- PTS,    Pterostilbene in Cancer Therapy: Enhancing Treatment Efficacy and Overcoming Resistance
- Review, Var, NA
CSCs↓, ChemoSen↑, BioAv↑, *toxicity↓,

Showing Research Papers: 351 to 400 of 532
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 532

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 2,   antiOx↑, 2,   Catalase↓, 1,   CYP1A1↑, 1,   CYP2E1↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 5,   H2O2↑, 1,   HO-1↑, 1,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 2,   MDA↑, 1,   NOX4↑, 1,   NRF2↓, 1,   NRF2↑, 1,   Prx4↑, 1,   ROS↓, 1,   ROS↑, 23,   ROS⇅, 1,   SIRT3↓, 1,   SOD↑, 1,   SOD2↓, 2,   SOD2↑, 1,   Trx↓, 1,   TrxR↓, 2,  

Metal & Cofactor Biology ⓘ

TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   EGF↓, 2,   ETC↑, 1,   MMP↓, 6,   OCR↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   cMyc↓, 4,   CYP3A4↓, 1,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   HK2↓, 2,   lactateProd↓, 1,   NADH:NAD↓, 1,   PPARγ↑, 1,   TCA↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 7,   p‑Akt↓, 1,   Apoptosis↑, 12,   BAD↑, 1,   Bak↑, 2,   BAX↑, 5,   Bcl-2↓, 3,   Bcl-xL↓, 1,   Casp↑, 1,   Casp3↑, 7,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 5,   Cyt‑c↝, 1,   Diablo↑, 1,   DR4↑, 2,   DR5↑, 2,   Fas↑, 1,   Ferroptosis↑, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 1,   iNOS↓, 2,   JNK↓, 1,   MAPK↓, 2,   Mcl-1↓, 1,   Myc↓, 1,   p27↑, 2,   survivin↓, 3,   Telomerase↓, 2,   TRAIL↑, 1,   TRAIL⇅, 1,   TRAILR↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   other↓, 1,   other↝, 3,   SD↑, 1,   tumCV↓, 4,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   ER Stress↑, 4,   PERK↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   p62↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair ⓘ

DNAdam↑, 4,   P53↑, 8,   PARP↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   E2Fs↓, 2,   P21↑, 6,   p‑RB1↓, 1,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State ⓘ

cFos↓, 1,   cMET↓, 1,   CSCs↓, 5,   Diff↑, 1,   EMT↓, 6,   ERK↓, 3,   GSK‐3β↓, 2,   HDAC↓, 3,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   LRP6↓, 1,   mTOR↓, 6,   mTORC1↓, 1,   NOTCH↓, 3,   PI3K↓, 4,   PTEN↑, 4,   RAS↓, 2,   STAT1↓, 1,   STAT3↓, 7,   STAT6↓, 1,   TumCG↓, 9,   Wnt↓, 2,  

Migration ⓘ

AP-1↓, 1,   Ca+2↝, 1,   CD31↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   ITGB1↓, 1,   ITGB6↓, 1,   Ki-67↓, 2,   KRAS↓, 1,   miR-19b↓, 1,   MMP2↓, 5,   MMP9↓, 5,   MMPs↓, 3,   PKCδ↓, 1,   SOX4↑, 1,   TIMP1↑, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 8,   TumMeta↓, 5,   TumMeta↑, 1,   Twist↓, 2,   Vim↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 6,   ATF4↑, 1,   ATF4↝, 1,   EGFR↓, 3,   HIF-1↓, 1,   Hif1a↓, 5,   LOX1↓, 1,   NO↑, 1,   VEGF↓, 7,  

Barriers & Transport ⓘ

BBB↑, 2,   GLUT1↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 5,   COX2↑, 1,   CRP↓, 1,   CXCR4↓, 1,   ICAM-1↓, 1,   Igs↑, 1,   IL10↑, 1,   IL1β↓, 1,   IL1β↑, 1,   IL6↓, 4,   IL8↓, 1,   INF-γ↓, 1,   Inflam↓, 3,   JAK↓, 1,   JAK1↓, 1,   NF-kB↓, 13,   NF-kB↑, 1,   NK cell↑, 1,   p65↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   TLR4↓, 1,   TNF-α↓, 4,  

Cellular Microenvironment ⓘ

pH↓, 1,  

Protein Aggregation ⓘ

PP2A↑, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,   ER(estro)↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 15,   BioAv↑, 21,   BioAv↝, 6,   BioEnh↑, 1,   ChemoSen↑, 19,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 8,   Dose∅, 3,   eff↓, 2,   eff↑, 12,   eff↝, 1,   Half-Life↓, 3,   Half-Life↝, 5,   Half-Life∅, 1,   MDR1↓, 1,   MRP1↓, 1,   P450↓, 1,   RadioS↑, 7,   selectivity↑, 10,  

Clinical Biomarkers ⓘ

BP↓, 1,   CRP↓, 1,   EGFR↓, 3,   GutMicro↑, 1,   GutMicro↝, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 4,   Ki-67↓, 2,   KRAS↓, 1,   Myc↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 5,   AntiTum↑, 2,   chemoP↑, 1,   ChemoSideEff↓, 1,   OS↑, 5,   QoL↑, 1,   Risk↓, 1,   toxicity↓, 4,   toxicity↝, 1,   toxicity∅, 2,   TumVol↓, 1,   TumW↓, 1,   Weight↑, 1,  
Total Targets: 242

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 8,   Catalase↑, 5,   GPx↑, 2,   GPx1↑, 1,   GSH↑, 6,   GSR↑, 2,   GSTs↑, 1,   H2O2↓, 1,   HO-1↑, 3,   lipid-P↓, 3,   MDA↓, 2,   NQO1↑, 2,   NRF2↓, 1,   NRF2↑, 7,   NRF2⇅, 1,   ROS↓, 13,   ROS⇅, 1,   SOD↑, 6,   SOD1↑, 1,   SOD2↑, 1,   Trx↑, 1,   TrxR↑, 1,  

Mitochondria & Bioenergetics ⓘ

mtDam↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↑, 1,   CREB↑, 1,   p‑CREB↑, 1,   CYP3A2↓, 1,   FAO↑, 1,   LDH↓, 1,   LDL↓, 1,   lipoGen↓, 1,   NADPH↓, 1,   PPARα↑, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 1,   MAPK↝, 1,  

Transcription & Epigenetics ⓘ

other↑, 5,   other↝, 2,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

DNA Damage & Repair ⓘ

PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   IGF-1↑, 1,  

Migration ⓘ

5LO↓, 1,   AP-1↓, 1,   E-sel↓, 1,   MMPs↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   NO↓, 2,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 2,   IL1β↓, 2,   IL4↓, 1,   IL8↓, 1,   Inflam↓, 9,   MCP1↓, 1,   NF-kB↓, 2,   p65↓, 1,   PGE2↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 1,   GABA↑, 1,   PSD95↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 7,   BioAv↑, 21,   BioEnh↑, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 4,   Half-Life↓, 1,   Half-Life↑, 5,   Half-Life↝, 1,   P450↓, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   BP↓, 2,   GutMicro↑, 1,   GutMicro↝, 1,   LDH↓, 1,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cardioP↑, 4,   chemoP↑, 2,   cognitive↑, 3,   hepatoP↑, 3,   memory↑, 3,   motorD↑, 1,   neuroP↑, 6,   Risk↑, 1,   toxicity↓, 3,   toxicity↝, 2,   Weight↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 109

Scientific Paper Hit Count for: BioAv, bioavailability
29 Curcumin
20 chitosan
18 Baicalein
17 Chlorogenic acid
16 Quercetin
16 Selenium NanoParticles
16 Sulforaphane (mainly Broccoli)
15 Apigenin (mainly Parsley)
15 Resveratrol
14 Berberine
14 EGCG (Epigallocatechin Gallate)
14 Pterostilbene
13 Thymoquinone
11 Silymarin (Milk Thistle) silibinin
11 Lycopene
10 Alpha-Lipoic-Acid
10 Carvacrol
9 Astaxanthin
9 borneol
9 Honokiol
9 Rosmarinic acid
8 Capsaicin
8 Chrysin
8 Piperlongumine
8 Urolithin
7 Allicin (mainly Garlic)
7 Artemisinin
7 Betulinic acid
7 Luteolin
7 Phenethyl isothiocyanate
6 Silver-NanoParticles
6 Ashwagandha(Withaferin A)
6 Biochanin A
6 Thymol-Thymus vulgaris
6 Propolis -bee glue
5 beta-glucans
5 Baicalin
5 Boswellia (frankincense)
5 Piperine
5 Ellagic acid
5 Fisetin
5 Magnolol
5 Naringin
5 Selenite (Sodium)
4 5-Hydroxytryptophan
4 Celastrol
4 Phenylbutyrate
4 Vitamin C (Ascorbic Acid)
4 Shikonin
4 Aflavin-3,3′-digallate
3 Ascorbyl Palmitate
3 Gold NanoParticles
3 Berbamine
3 Boron
3 Caffeic acid
3 Folic Acid, Vit B9
3 Chocolate
3 Copper and Cu NanoParticles
3 Disulfiram
3 Ferulic acid
3 HydroxyTyrosol
3 Lecithin
3 Magnetic Fields
3 Niclosamide (Niclocide)
3 Silicic Acid
3 Spermidine
2 3-bromopyruvate
2 Auranofin
2 Astragalus
2 Citric Acid
2 Chemotherapy
2 Aspirin -acetylsalicylic acid
2 Paclitaxel
2 Atorvastatin
2 immunotherapy
2 Butyrate
2 Melatonin
2 Chlorophyllin
2 Choline
2 Coenzyme Q10
2 Camptothecin
2 Emodin
2 Shilajit/Fulvic Acid
2 Gallic acid
2 Hydroxycinnamic-acid
2 magnetic nanoparticles
2 nicotinamide adenine dinucleotide
2 Oleuropein
2 Rutin
2 Selenium
2 Ursolic acid
1 Aluminum
1 Aromatherapy
1 Gemcitabine (Gemzar)
1 Aloe anthraquinones
1 doxorubicin
1 Docetaxel
1 Radiotherapy/Radiation
1 beta-carotene(VitA)
1 Bicalutamide
1 Bacopa monnieri
1 Carnosic acid
1 urea
1 capecitabine
1 Catechins
1 Cat’s Claw
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Cannabidiol
1 irinotecan
1 Crocetin
1 Electrical Pulses
1 Fenbendazole
1 flavonoids
1 Kaempferol
1 MCToil
1 Gambogic Acid
1 Genistein (soy isoflavone)
1 Hydrogen Gas
1 HydroxyCitric Acid
1 itraconazole
1 Methylene blue
1 Metformin
1 Magnesium
1 Bicarbonate(Sodium)
1 Oleocanthal
1 Oxygen, Hyperbaric
1 Cisplatin
1 Psoralidin
1 Parthenolide
1 enzalutamide
1 salinomycin
1 Date Fruit Extract
1 Tomatine
1 Vitamin B3,Niacin
1 Vitamin D3
1 Vitamin E
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:792  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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