DNAdam Cancer Research Results

DNAdam, DNA damage: Click to Expand ⟱
Source: HalifaxProj(prevent)
Type:
DNA damage plays a crucial role in the development of cancer. The integrity of DNA is essential for the proper functioning of cells, and when DNA is damaged, it can lead to mutations that may contribute to cancer progression.
Scientific Papers found: Click to Expand⟱
3138- VitC,    The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity
- in-vitro, RCC, RCC4 - in-vitro, CRC, HCT116 - in-vitro, BC, MDA-MB-435 - in-vitro, Ovarian, SKOV3 - in-vitro, Colon, SW48 - in-vitro, GBM, U251
eff↑, Warburg↓, BioAv↑, ROS↑, DNAdam↑, ATP↓, eff↑, necrosis↑, PARP↑,
3109- VitC,    Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway
- in-vitro, Lung, H1299
TumMeta↓, NRF2↑, HO-1↑, cl‑Casp3↑, cl‑Casp9↑, DNAdam↑, Apoptosis↑, other↑, selectivity↑,
3104- VitC,    Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations
*antiOx↑, *ROS↓, *DNAdam↓, ROS↑, TET1↑, CSCs↓, HIF-1↓, BioAv↑, selectivity↑,
3128- VitC,    Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages
- in-vitro, Nor, NA
*ROS↓, *DNAdam↓, *TNF-α↓, *IL6↓, *p38↓,
4468- VitC,  SSE,    Selenium modulates cancer cell response to pharmacologic ascorbate
- in-vivo, GBM, U87MG - in-vitro, CRC, HCT116
eff↓, TumCD↑, ChemoSen↑, ROS⇅, DNAdam↑, PARP↑, NAD↓, Glycolysis↓, Fenton↑, lipid-P↑, eff↓, H2O2↑, other↝,
2284- VitK2,    Menadione-induced DNA damage in a human tumor cell line
- in-vitro, BC, MCF7
DNAdam↑, ROS↑,
2276- VitK2,    Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat
- in-vivo, Nor, NA
*Albumin↑, *AST↓, *ALAT↓, *Keap1↓, *NRF2↑, *HO-1↑, *COX2↓, *iNOS↓, *TNF-α↓, *TIMP1↓, *TGF-β↓, *ROS↓, *DNAdam↓, *Inflam↓,
1824- VitK2,    Vitamin K and its analogs: Potential avenues for prostate cancer management
- Review, Pca, NA
AntiCan↑, toxicity∅, Risk↓, Apoptosis↑, ROS↑, TumCCA↑, eff↑, DNAdam↑, MMP↓, Cyt‑c↑, pro‑Casp3↑, FasL↑, Fas↑, TumAuto↑, ChemoSen↑, RadioS↑,
1832- VitK3,  VitC,    Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism
- in-vitro, AML, K562
ROS↑, H2O2↑, NF-kB↑, P53↑, cJun↑, Casp3↑, MMP↓, DNAdam↑, Dose?,
604- ZO,    Plant-Mediated Zinc Oxide Nanoparticles: Advances in the New Millennium towards Understanding Their Therapeutic Role in Biomedical Applications
- Review, NA, NA
ROS↑, Apoptosis↑, DNAdam↑,

Showing Research Papers: 351 to 360 of 360
Prev Page 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 360

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Fenton↑, 1,   H2O2↑, 2,   HO-1↑, 1,   lipid-P↑, 1,   NRF2↑, 1,   ROS↑, 6,   ROS⇅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MMP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,   NAD↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 3,   Casp3↑, 1,   cl‑Casp3↑, 1,   pro‑Casp3↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   Fas↑, 1,   FasL↑, 1,   necrosis↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,   other↑, 1,   other↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 7,   P53↑, 1,   PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,  

Migration(tgid=13) ⓘ

TET1↑, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

HIF-1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   ChemoSen↑, 2,   Dose?, 1,   eff↓, 2,   eff↑, 3,   RadioS↑, 1,   selectivity↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   Risk↓, 1,   toxicity∅, 1,  
Total Targets: 45

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   HO-1↑, 1,   Keap1↓, 1,   NRF2↑, 1,   ROS↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,   p38↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,  

Migration(tgid=13) ⓘ

TGF-β↓, 1,   TIMP1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   Albumin↑, 1,   AST↓, 1,   IL6↓, 1,  
Total Targets: 19

Scientific Paper Hit Count for: DNAdam, DNA damage
31 Silver-NanoParticles
16 Radiotherapy/Radiation
16 Vitamin C (Ascorbic Acid)
12 Magnetic Fields
12 Curcumin
9 Fisetin
7 Cisplatin
7 Ashwagandha(Withaferin A)
7 Chrysin
7 Quercetin
7 Lycopene
7 salinomycin
7 Selenium NanoParticles
6 Artemisinin
6 Chemotherapy
6 Apigenin (mainly Parsley)
6 Berberine
6 Carvacrol
6 Emodin
6 Piperlongumine
6 Sulforaphane (mainly Broccoli)
5 Copper and Cu NanoParticles
5 Allicin (mainly Garlic)
5 Baicalein
5 Betulinic acid
5 Ellagic acid
5 diet FMD Fasting Mimicking Diet
5 Dandelion Root
5 nicotinamide adenine dinucleotide
5 Selenite (Sodium)
5 Thymoquinone
4 Auranofin
4 doxorubicin
4 Beta-Caryophyllene
4 Capsaicin
4 Thymol-Thymus vulgaris
4 Echinacea
4 Electrical Pulses
4 Vitamin B3,Niacin
4 Propolis -bee glue
4 Resveratrol
4 Shikonin
3 Anethole/trans-Anethole
3 borneol
3 Boron
3 Boswellia (frankincense)
3 Rosmarinic acid
3 Cat’s Claw
3 Disulfiram
3 EGCG (Epigallocatechin Gallate)
3 Eurycomanone
3 Eugenol
3 Magnolol
3 Magnetic Field Rotating
3 Nimbolide
3 Phenethyl isothiocyanate
3 α-Santalol/Sandalwood oil
3 Selenium
3 Silymarin (Milk Thistle) silibinin
3 Vitamin K2
2 1,8-Cineole
2 chitosan
2 Moringa oleifera
2 Metformin
2 Melatonin
2 Astaxanthin
2 Aloe anthraquinones
2 brusatol
2 Bruteridin(bergamot juice)
2 Caffeic acid
2 Carnosic acid
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Crocetin
2 diet Short Term Fasting
2 Gallic acid
2 Garcinol
2 Geraniol
2 γ-linolenic acid (Borage Oil)
2 Hydroxycinnamic-acid
2 Juglone
2 Propyl gallate
2 Ursolic acid
2 VitK3,menadione
1 3-bromopyruvate
1 5-Hydroxytryptophan
1 Astragalus
1 Gold NanoParticles
1 Photodynamic Therapy
1 entinostat
1 tamoxifen
1 Alpha-Lipoic-Acid
1 Fennel Oil/Foeniculum vulgare
1 Ascorbyl Palmitate
1 Baicalin
1 Biochanin A
1 Gemcitabine (Gemzar)
1 Bromelain
1 Black phosphorus
1 α-Bisabolol / Chamomile oil
1 Zinc
1 carboplatin
1 Catechins
1 Chlorophyllin
1 Cinnamon
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Carvone
1 chemodynamic therapy
1 Dichloroacetate
1 Deguelin
1 Diclofenac
1 Date Fruit Extract
1 D-limonene
1 immunotherapy
1 Butyrate
1 Ferulic acid
1 Galloflavin
1 Gambogic Acid
1 Honokiol
1 HydroxyTyrosol
1 Licorice
1 Luteolin
1 Methyl salicylate / Sweet Birch oil
1 Piperine
1 Plumbagin
1 Sulfasalazine
1 Aflavin-3,3′-digallate
1 temozolomide
1 Urolithin
1 Iron
1 Magnesium
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:82  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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