tumCV Cancer Research Results

tumCV, Cell Viability: Click to Expand ⟱
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Cell Viability
Scientific Papers found: Click to Expand⟱
8097- KAE,    The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells
- in-vitro, CRC, LS174T
ChemoSen↑, tumCV↓, Apoptosis↑, TumCCA↑, ROS↓, Casp3↑, Casp9↑, cl‑PARP↑, p‑STAT3↓, Akt↓, FOXO3↓, NF-kB↓, VEGF↓, TS↓, TK1↓,
8100- KAE,    Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways
- in-vitro, Cerv, HeLa
*antiOx↑, *AntiTum↑, Apoptosis↑, TumCD↑, tumCV↓, PI3K↓, Akt↓, hTERT/TERT↓,
8103- KAE,    The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions
- in-vitro, HCC, HUH7
Dose↝, HIF-1↓, tumCV↓,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8107- KAE,    Kaempferol Induces Cell Death in A2780 Ovarian Cancer Cells and Increases Their Sensitivity to Cisplatin by Activation of Cytotoxic Endoplasmic Reticulum-Mediated Autophagy and Inhibition of Protein Kinase B
- in-vitro, Ovarian, A2780S
Apoptosis↑, tumCV↓, TumCP↓, TumAuto↑, GRP78/BiP↑, PERK↑, ATF6↑, IRE1↑, LC3II↑, Beclin-1/ATG6↑, Ca+2↑, ChemoSen↑, ER Stress↑,
8059- KAE,    Kaempferol Inhibits Cervical Cancer Cells by Inducing Apoptosis and Autophagy via Inactivation of the PI3K/AKT/mTOR Signaling Pathway
- in-vitro, Cerv, KB
*antiOx↑, *Inflam↓, tumCV↓, TumCMig↓, TumAuto↑, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Apoptosis↑, PI3K↓, Akt↓, mTOR↓,
8064- KAE,    Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1 - in-vitro, PC, SNU-213
AntiCan↑, tumCV↓, Apoptosis↑, TumCMig↓, *toxicity↓, Dose?,
8065- KAE,    Kaempferol, a new nutrition-derived pan-inhibitor of human histone deacetylases
- in-vitro, Liver, HepG2 - in-vitro, CRC, HCT116
HDAC↓, tumCV↓, TumCP↓, selectivity↑, ac‑H3↝,
8075- KAE,  QC,    Systematic review on anticancer potential of Kaempferol and quercetin against lung, breast, and colorectal cancers with emphasis on in vitro and in vivo studies
- Review, Var, NA
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, P53↑, Bcl-2↓, PARP↑, ERK↓, IQGAP3↓, γH2AX↑, cl‑Casp3↑, cl‑Casp9↑, Rho↓, Rac1↓, MMP2↓, MMP9↓, CTSB↓, CTSD↓, O-Glc↓, SERPINH1/HSP47↓, EMT↓, angioG↓, EGF↓, VEGFR2/KDR/Flk1↓, RadioS↑,
9002- L-THE,    Effects of theanine on growth of human lung cancer and leukemia cells as well as migration and invasion of human lung cancer cells
- in-vitro, Lung, A549 - in-vitro, AML, K562
tumCV↓, Synergy↑, TumCMig↓, TumCI↓, Dose↝,
8121- LA,    Exploring Anticancer Potential of Lactobacillus Strains: Insights into Cytotoxicity and Apoptotic Mechanisms on HCT 115 Cancer Cells
- in-vitro, CRC, NA
tumCV↓, BAX↑, Bcl-2↓,
8150- lamb,    Reactive oxygen species dependent phosphorylation of the liver kinase B1/AMP activated protein kinase/ acetyl-CoA carboxylase signaling is critically involved in apoptotic effect of lambertianic acid in hepatocellular carcinoma cells
- in-vitro, HCC, HepG2 - in-vitro, HCC, SK-HEP-1
lipidLev↓, TumCCA↑, cl‑Casp3↑, cl‑PARP↑, AMPK↑, Akt↓, mTOR↓, Bcl-2↓, Bcl-xL↓, COX2/PTGS2↓, ROS↑, eff↓, p‑STK11/LKB1↑, p‑ACC↑, *Obesity↓, *Stress↓, *antiAll↑, tumCV↓, selectivity↑, TumCP↓, *antiAll↑,
8165- LapC,    Lapachol interferes with the cell cycle and inhibits proliferation and migration of bladder tumor cells with effects on ncRNA expression
- in-vitro, Bladder, RT4
tumCV↓, TumCMig↓, TumCCA↑, SBF2-AS1↓, JHDM1D-AS1↓,
8175- Las,    Lasiodin Inhibits Proliferation of Human Nasopharyngeal Carcinoma Cells by Simultaneous Modulation of the Apaf-1/Caspase, AKT/MAPK and COX-2/NF-κB Signaling Pathways
- in-vitro, NPC, NA
tumCV↓, TumCMig↓, APAF1↑, Cyt‑c↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, Apoptosis↑, p‑Akt↓, p‑ERK↓, p‑p38↓, p‑JNK↓, COX2/PTGS2↓, NF-kB↓, chemoPv↑,
8177- Las,    Lasiokaurin Regulates PLK1 to Induce Breast Cancer Cell G2/M Phase Block and Apoptosis
- vitro+vivo, BC, MDA-MB-231
Dose↝, tumCV↓, Apoptosis↑, TumCCA↑, PLK1↓, CDC25↓, Akt↓,
8249- LCA,    Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells
- in-vitro, NSCLC, NA
tumCV↓, LDH↑, Apoptosis↑, selectivity↑, LC3II↑, TumAuto↑, ER Stress↑, CHOP/DDIT3↑, chemoP↑, RenoP↑, cl‑PARP↑, cl‑Casp7↑, cl‑Casp3↑,
8248- LCA,    Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2/M Cell Cycle Arrest and ER Stress
- in-vitro, NSCLC, A549 - in-vitro, Lung, H460
tumCV↓, TumCG↓, TumCCA↑, MDM2↓, CycB/CCNB1↓, cDC2↓, CDC25↓, Casp3↑, PARP↑, ER Stress↑, p‑eIF2α↑, ATF4↑, TumCP↓, selectivity↑, Bcl-xL↓, Bcl-2↓,
8241- LCA,    Licochalcone A induces apoptotic cell death via JNK/p38 activation in human nasopharyngeal carcinoma cells
- in-vitro, NPC, NA
tumCV↓, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, ERK↑, p38↑, JNK↑, *antiAll↑, *Bacteria↓, *Inflam↓, *antiOx↑, *AntiCan↑,
8253- LCA,    Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma
- in-vitro, SCC, HSC4
*AntiTum↑, *angioG↓, *AntiP↑, *antiOx↑, *Bacteria↓, *Inflam↓, tumCV↓, Sp1/3/4↓, p27/CDKN1B↑, P21↑, cycD1/CCND1↓, Mcl-1↓, survivin↓, Apoptosis↑,
8260- LCA,    Licochalcone A Induces Ferroptosis in Hepatocellular Carcinoma via Reactive Oxygen Species Activated by the SLC7A11/GPX4 Pathway
- vitro+vivo, Liver, HepG2 - in-vitro, Liver, HUH7
tumCV↑, xCT/SLC7A11↓, Ferroptosis↑, GPx4↑, ROS↑, TumCP↓, TumCD↑, Iron↑,
8209- LCA,    Licochalcone A Exerts Anti-Cancer Activity by Inhibiting STAT3 in SKOV3 Human Ovarian Cancer Cells
- in-vitro, Ovarian, SKOV3
tumCV↓, TumCCA↑, ROS↑, MMP↓, Apoptosis↑, cl‑Casp↑, Cyt‑c↑, STAT3↓, TumCP↓, Dose↝, p‑STAT3↓,
8208- LCA,    Licochalcone A inhibits PI3K/Akt/mTOR signaling pathway activation and promotes autophagy in breast cancer cells
- in-vitro, BC, MCF7
*Inflam↓, *AntiCan↑, *AntiP↑, LC3II↑, PI3K↓, Akt↓, mTOR↓, Casp3↑, Bcl-2↓, TumAuto↑, Apoptosis↑, tumCV?,
8213- LCA,    Licochalcone A inhibits hypoxia-inducible factor-1α accumulation by suppressing mitochondrial respiration in hypoxic cancer cells
- in-vitro, CRC, HCT116 - in-vitro, Lung, H1299 - in-vitro, Lung, H322
Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, ROS↑, mitResp↓, ATP↓, tumCV?,
8210- LCA,    Licochalcone A-Induced Human Bladder Cancer T24 Cells Apoptosis Triggered by Mitochondria Dysfunction and Endoplasmic Reticulum Stress
- in-vitro, Bladder, T24/HTB-9
chemoPv↑, TumCP↓, ROS↑, Apoptosis↑, mtDam↑, Casp3↑, cl‑PARP↑, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, Casp12↑, mt-ROS↑, tumCV↓, GSH/GSSG↓, NA↓,
8211- LCA,    Licochalcone A induces endoplasmic reticulum stress-mediated apoptosis of endometrial cancer cells via upregulation of GRP78 expression
- in-vitro, EC, NA
AntiCan↑, tumCV↓, Apoptosis↑, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑,
8287- LE,    New insights into the antioxidant and apoptotic potential of Glycyrrhiza glabra L. during hydrogen peroxide mediated oxidative stress: An in vitro and in silico evaluation
- in-vitro, Nor, NA
*antiOx↑, *MDA↓, *lipid-P↓, *SOD?, *Catalase↑, *GSTs↑, *GPx↑, *GR↑, selectivity↑, tumCV↓, Casp8↑, Casp3↑, Bcl-2↓,
8265- LE,    Glycyrrhizin ameliorates colorectal cancer progression by regulating NHEJ pathway through inhibiting HMGB1-induced DNA damage response
- vitro+vivo, CRC, NA
TumCG↓, Inflam↓, tumCV↓, DNAdam↑, Apoptosis↑, Casp3↑, TumCCA↑, cycD1/CCND1↓, HMGB1↓, NHEJ↓, TumCP↓,
8276- LE,  Cisplatin,    Glycyrrhizin enhances the antitumor activity of cisplatin in non‑small cell lung cancer cells by influencing DNA damage and apoptosis
- in-vitro, NSCLC, NA
tumCV↓, ChemoSen↑, Apoptosis↑, TumCCA↑, Bcl-xL↑, cl‑Casp↑, γH2AX↑, P53↑,
8278- LE,    Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology
- Review, Var, NA
*Ingr↝, *AntiCan↑, *AntiDiabetic↑, *AntiBio↑, *Inflam↓, *antiAll↑, *hepatoP↑, *cough?, *SoreThr?, *toxicity↝, *cardioP↑, *BioAv↝, *PGE2↓, *COX2/PTGS2↓, *AntiAg↑, *ROS↓, *NLRP3↓, *NF-kB↓, *AP-1↓, TumCCA↑, Apoptosis↑, TumMeta↑, *Dose↝, *Dose↝, Ingr↝, TumAuto↑, LC3II↑, PI3K↓, Akt↓, mTOR↓, *cognitive↑, *BloodF↑, ChemoSen↑, ROS↓, *chemoP↑, ROS↑, tumCV↓, MMP↓, *AntiBio↑, *toxicity↝,
8279- LE,    18β-Glycyrrhetinic Acid Has Anti-Cancer Effects via Inducing Apoptosis and G2/M Cell Cycle Arrest, and Inhibiting Migration of A549 Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H23 - in-vitro, Lung, H460
tumCV↓, selectivity↑, Apoptosis↑, ROS↑, TumCCA↑, TumCMig↓, TumCP↓, MMP↓, BAD↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, p‑STAT3↓, NF-kB↓,
8191- LGE,    Lemongrass (Cymbopogon citratus (D.C.) Stapf) Presents Antitumoral Effect and Improves Chemotherapy Activity in Prostate Cancer Cells
- in-vitro, Pca, DU145
AntiTum↑, tumCV↓, TumCP↓, ROS?, TumCCA?, selectivity↑,
8294- lign,    Secoisolariciresinol diglucoside induces pyroptosis by activating caspase-1 to cleave GSDMD in colorectal cancer cells
- vitro+vivo, CRC, LoVo - in-vitro, CRC, SW-620 - in-vitro, NA, SW480 - in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116
tumCV↓, Pyro↑, cl‑GSDMD↑, cl‑Casp1↑, ROS↑, p‑PI3K↓, TumCG↓, BAX↑, Cyt‑c↑, PI3K↓, Akt↓,
8302- lign,    The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth
- vitro+vivo, BC, E0771 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
Dose↝, TumVol↓, p‑p65↓, NF-kB↓, tumCV↓, Inflam↓,
8330- LIN,    SIRT3-SOD2-ROS pathway is involved in linalool-induced glioma cell apoptotic death
- in-vitro, GBM, U87MG
tumCV↓, OCR↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, Casp3↑, Casp9↑, Apoptosis↑, SOD↓, SIRT3↓, mt-ROS↑,
8326- LIN,    Linalool in cancer pharmacology: pharmacokinetic limitations and preclinical cytotoxic evidence for translational development
- Review, Var, NA
Dose↝, *BioAv↓, BioAv↝, tumCV↓, compI↓, compII↓, ROS↑, ATP↓, GSH↓, mtDam↑, Casp↑, NF-kB↓, MMP↓, TumCCA↑, PI3K↓, Akt↓, angioG↓, CD31/PECAM-1↓, Ki-67↓,
8325- LIN,    Validating linalool as a potential drug for breast cancer treatment based on machine learning and molecular docking
- in-vitro, BC, NA
tumCV↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, TumCCA↑, PPARγ↑, PGK1↓,
8321- LIN,  doxoR,    Linalool, a plant-derived monoterpene alcohol, reverses doxorubicin resistance in human breast adenocarcinoma cells
- in-vitro, BC, MCF7
ChemoSen↑, EPR↑, Bcl-xL↓, P-gp/ABCB1↓, TumCCA⇅, tumCV↓, Apoptosis↑,
8319- LIN,    Linalool monoterpene exerts potent antitumor effects in OECM 1 human oral cancer cells by inducing sub-G1 cell cycle arrest, loss of mitochondrial membrane potential and inhibition of PI3K/AKT biochemical pathway
- in-vitro, Oral, OECM-1 - in-vitro, Nor, FR-2
tumCV?, selectivity↑, Apoptosis↑, TumCCA↑, p‑PI3K↓, p‑Akt↓, MMP↓,
8386- LT,    Luteolin induces apoptosis in Philadelphia chromosome-positive acute lymphoblastic leukemia cell by regulating the PI3K/AKT signaling pathway
- in-vitro, ALL, SUP-B15
tumCV↓, ROS↑, MMP↓, ATP↓, p‑PI3K↓, p‑Akt↓, p‑STAT3↓, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, TumCP↓, eff↓, ChemoSen↑, FAK↓, Synergy↑, BioAv↓, BioAv↑,
8403- LT,    Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells
- in-vitro, CRC, HT-29
tumCV↓, selectivity↑, Apoptosis↑, Casp↑, MMP↓, Ca+2↑, BAX↑, Bcl-2↓, Cyt‑c↑, Casp9↑, Casp3↑, ROS↓, SOD↑, Catalase↑, GSH↑, antiOx↑, MAPK↑,
8402- LT,    Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin pathway
- vitro+vivo, CRC, T24/HTB-9
tumCV↓, TumCCA↑, p‑S6↓, P21↑, Trx1↑, ROS↓, Ki-67↓, mTOR↓, TumCP↓,
8397- LT,    Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules
- Review, Var, NA
tumCV↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, mTOR↓, PI3K↓, Akt↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Apoptosis↑, hTERT/TERT↓, AP-1↓, NF-kB↓, MAPK↓, HSP90↓, AR↓, IGF-1R↓, Akt↓, NOTCH↓, IL6↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, TumVol∅, TumW∅, miR-34a↑, miR-107↑, miR-139-5p↑, miR-422a↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, *toxicity↓,
8369- LT,    Luteolin inhibits proliferation of lung cancer A549 cells by increasing ROS production and inhibiting the AKT/mTOR signaling pathway and HO-1 expression
- in-vitro, Lung, A549
tumCV↓, TumCP↓, ROS↑, BAX↑, cl‑Casp9↑, Beclin-1/ATG6↑, LC3B-II↑, Bcl-2↓, p62↓, TumAuto↑, p‑Akt↓, p‑mTOR↓, HO-1↓,
2910- LT,  FA,    Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment
- in-vitro, BC, 4T1 - in-vivo, NA, NA
BioAv↓, BioAv↑, eff↑, tumCV↓, e-H2O2↓, i-H2O2∅,
2915- LT,    Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells
- in-vitro, Colon, HT29 - in-vitro, CRC, SNU-407 - in-vitro, Nor, FHC
DNMTs↓, TET1↑, NRF2↑, HDAC↓, tumCV↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, ROS↓, GSS↑, Catalase↑, HO-1↑, DNMT1↓, DNMT3A↓, TET1↑, TET3↑, TET2↓, P53↑, P21↑,
8345- Lut,    Lutein inhibits breast cancer cell growth by suppressing antioxidant and cell survival signals and induces apoptosis
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, SOD2↓, HO-1↓, NRF2↓, p‑Akt↓, p‑ERK↓, NF-kB↓, Apoptosis↑, Casp3↑, Bcl-2↓, PARP↓, ROS↓, XBP-1↓, Dose↝, Risk↓, MMP↓, selectivity↑, p‑Akt↓,
8342- Lut,  Cisplatin,    Lutein Influences Cisplatin Sensitivity Through Differential Regulation of DNA Damage Response Genes in Breast Cancer Cells
- in-vitro, Nor, HUVECs - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
tumCV↓, DNAdam↑, selectivity↑, ROS↑, Casp3↑, BRCA1↓, Ku70/XRCC6↓, XRCC1↓, ChemoSen↑, NA↓,
8414- Lyco,    Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits
- Review, Var, NA - Review, AD, NA
*ROS↓, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiArt↑, *Obesity↓, *Wound Healing↑, *BioAv↑, *GSTs↑, *Trx1↑, *SOD↑, *Catalase↑, *ALAT↓, *LDH↓, *AST↓, *MDA↓, *cognitive↑, *memory↑, *NeuroI↓, *Aβ↓, *LRP1↑, *RAGE↓, *NRF2↑, *HO-1↑, tumCV?, Bax:Bcl2↑, DNAdam↑, Apoptosis↑, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, ROS↓, TumCCA↑, Akt↓, *Synergy↑, *MDA↓, *NF-kB↓, *TGF-β↓, *Casp3↓, *Catalase↑, *GSH↑, *Bcl-2↑, *IL10↑, *MUC1↑, *IBI↑, *RenoP↑, *ChemoSen↑, *Synergy↑, *Synergy↑, *BMD↑,
4777- Lyco,    Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells
- in-vitro, GC, AGS
*antiOx↑, tumCV↓, DNAdam↑, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, ROS↓, NF-kB↓, COX2/PTGS2↓, EGFR↓, p38↓,
4779- Lyco,    Lycopene Inhibits Reactive Oxygen Species-Mediated NF-κB Signaling and Induces Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, PANC1
ROS↓, NF-kB↓, tumCV↓, Casp3↑, Apoptosis↑, OCR↓, MMP↓, CIP2A↓, survivin↓, Casp3↑, Bax:Bcl2↑,

Showing Research Papers: 351 to 400 of 622
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 622

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 2,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 2,   antiOx↑, 10,   ARE/EpRE↑, 1,   Catalase↓, 7,   Catalase↑, 5,   Fenton↑, 2,   GPx↓, 2,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 9,   GPx4↑, 1,   GPx4∅, 1,   GSH↓, 22,   GSH↑, 4,   GSH⇅, 1,   GSH∅, 1,   GSH/GSSG↓, 2,   GSR↓, 2,   GSS↑, 1,   GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 2,   e-H2O2↓, 1,   i-H2O2∅, 1,   HO-1↓, 6,   HO-1↑, 7,   HO-2↓, 1,   HO-2↑, 1,   Iron↑, 5,   Iron↝, 1,   i-Iron↓, 1,   i-Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 7,   lipid-P↑, 10,   MDA?, 1,   MDA↑, 8,   NOX↓, 1,   NQO1?, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 12,   NRF2↑, 9,   p‑NRF2↑, 2,   p66Shc↓, 1,   p66Shc↑, 1,   Prx↓, 1,   ROS?, 3,   ROS↓, 31,   ROS↑, 232,   ROS⇅, 1,   ROS↝, 1,   ROS∅, 3,   i-ROS↑, 1,   mt-ROS↑, 13,   SOD↓, 8,   SOD↑, 4,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 4,   TAC↓, 1,   TAC↑, 2,   TBARS↑, 2,   Thiols↓, 2,   Thiols↝, 1,   TKT↓, 1,   Trx↓, 2,   Trx1↑, 1,   TrxR↓, 2,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   STEAP3↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 7,   compI↓, 3,   compII↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 2,   ETC↓, 2,   KIF2C↓, 1,   MFN2↓, 1,   mitResp↓, 3,   mitResp↑, 1,   mtDam↑, 28,   OCR↓, 4,   OXPHOS↓, 3,   OXPHOS↑, 3,   PDH↓, 1,   PDH↑, 1,   PINK1↑, 3,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↓, 2,   p‑ACC↑, 1,   ACLY↓, 1,   ALAT↓, 3,   AMP↑, 1,   AMPK↑, 18,   p‑AMPK↑, 4,   ATP↓, 17,   citrate↓, 1,   ECAR↓, 2,   ECAR↝, 1,   FAO↓, 1,   FASN↓, 3,   FASN↑, 1,   i-FASN↓, 1,   FBPase↑, 1,   G6PD↓, 1,   GAPDH↓, 1,   GLO-I↓, 1,   GLS↑, 1,   glucoNG↑, 1,   glucose↓, 2,   GlucoseCon↓, 9,   GlucoseCon∅, 1,   GlutMet↓, 1,   GlutMet↑, 1,   Glycolysis↓, 25,   GSK‐3β↓, 2,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 4,   Histones↑, 1,   HK2↓, 7,   HMG-CoA↓, 1,   IDH1↑, 1,   lactateProd↓, 12,   lactateProd∅, 1,   LDHA↓, 4,   LDL↓, 1,   lipidLev↓, 1,   lipoGen↓, 2,   NADPH↓, 1,   O-Glc↓, 1,   PDHB↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 4,   PDKs↓, 1,   PFK↓, 2,   PGK1↓, 1,   PKM2↓, 11,   p‑S6↓, 1,   SIRT1↓, 1,   SIRT1↑, 3,   SIRT2↓, 1,   TCA↓, 1,   TS↓, 1,   Warburg↓, 1,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 13,   AIF↝, 1,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 8,   Apoptosis↑, 288,   Apoptosis∅, 1,   mt-Apoptosis↑, 2,   ASK1↑, 1,   BAD↓, 1,   BAD↑, 7,   Bak↑, 3,   BAX↓, 2,   BAX↑, 107,   Bax:Bcl2↑, 26,   Bcl-2↓, 112,   Bcl-2↑, 2,   Bcl-xL↓, 20,   Bcl-xL↑, 2,   BID↑, 3,   BIM↑, 2,   BNIP3↑, 1,   BOK↑, 1,   Casp↑, 27,   cl‑Casp↑, 2,   proCasp↑, 1,   cl‑Casp1↑, 1,   Casp12↑, 6,   Casp3↓, 1,   Casp3↑, 155,   cl‑Casp3↓, 1,   cl‑Casp3↑, 40,   proCasp3↓, 1,   proCasp3↑, 1,   pro‑Casp3↓, 1,   CASP4↑, 1,   Casp6↓, 1,   Casp6↑, 2,   Casp7↑, 22,   cl‑Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 30,   Casp8∅, 1,   cl‑Casp8↑, 4,   Casp9↓, 2,   Casp9↑, 82,   cl‑Casp9↑, 17,   cFLIP↓, 3,   Cyt‑c↓, 1,   Cyt‑c↑, 70,   Diablo↑, 1,   DR5↑, 3,   Endon↑, 2,   FADD↑, 2,   Fas↑, 7,   FasL↑, 9,   Ferroptosis↓, 1,   Ferroptosis↑, 16,   cl‑GSDMD↑, 1,   GSDME↑, 1,   GSDME-N↑, 1,   IAP1↓, 1,   iNOS↓, 4,   Mcl-1↓, 14,   MDM2↓, 8,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 2,   NAIP↓, 1,   Necroptosis↑, 3,   necrosis↑, 4,   NOXA↑, 2,   p38↓, 4,   p38↑, 6,   p‑p38↓, 3,   p‑p38↑, 6,   PDCD4↑, 1,   proApCas↑, 1,   PUMA↑, 4,   Pyro↑, 4,   RIP3↑, 1,   p‑RIP3↑, 2,   survivin↓, 40,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 19,   TumCD∅, 1,   TUNEL↑, 1,   XIAP↓, 12,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 82,   Akt↑, 4,   p‑Akt↓, 37,   AKT1↓, 2,   Brk/PTK6↓, 1,   CaMKII ↓, 1,   CaMKII ↑, 1,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 1,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 19,   p‑EGFR↓, 2,   ERK↓, 23,   ERK↑, 6,   ERK↝, 1,   p‑ERK↓, 12,   p‑ERK↑, 3,   GRB2↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   HRAS↓, 1,   IGF-1R↓, 5,   IKKα↓, 3,   IKKα↑, 1,   p‑IκB↓, 1,   JAK↓, 1,   JAK1↓, 4,   JAK2↓, 9,   p‑JAK2↓, 1,   JNK↓, 4,   JNK↑, 12,   p‑JNK↓, 1,   p‑JNK↑, 6,   LIFR/CD118↓, 1,   MAPK↓, 10,   MAPK↑, 10,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 2,   MEK↓, 5,   p‑MEK↑, 1,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 47,   mTOR↑, 2,   p‑mTOR↓, 12,   mTORC2↓, 1,   mTORC2↑, 1,   p‑p70S6↓, 1,   P70S6K↓, 1,   p‑P70S6K↓, 2,   PI3K?, 1,   PI3K↓, 54,   PI3K↑, 1,   p‑PI3K↓, 13,   PI3k/Akt/mTOR↓, 2,   PKA↓, 2,   PKCδ↓, 3,   PKCδ↑, 1,   PRKCQ/PKCθ↓, 1,   PTEN↑, 8,   PTK2B / PYK2↓, 1,   e-Raf↓, 1,   RAS↓, 4,   RAS↑, 1,   RCC1↓, 1,   RIP1↓, 1,   Sp1/3/4↓, 6,   Src↓, 1,   STAT↓, 3,   STAT3↓, 40,   STAT3↑, 1,   p‑STAT3↓, 15,   STAT4↓, 1,   STAT4↑, 1,   STAT5↓, 4,   p‑STK11/LKB1↑, 2,   TK1↓, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 4,   ChrMod↝, 1,   cJun↓, 1,   p‑cJun↑, 1,   cMyc↓, 16,   cMyc↑, 2,   DNMT1↓, 6,   DNMT3A↓, 4,   DNMT3B↓, 2,   DNMTs↓, 2,   FOXM1↓, 1,   FOXO1↓, 1,   FOXO3↓, 2,   p‑FOXO3↓, 1,   FOXO4↓, 1,   GATA3↑, 1,   ac‑H3↑, 3,   ac‑H3↝, 1,   ac‑H4↑, 3,   HATs↓, 1,   HDAC↓, 8,   HDAC1↓, 4,   HDAC2↓, 4,   HDAC3↓, 2,   HDAC6↓, 1,   HMTs↓, 2,   JHDM1D-AS1↓, 1,   miR-107↑, 1,   miR-139-5p↑, 1,   miR-148a↑, 1,   miR-149↑, 1,   miR-155↓, 2,   miR-21↓, 2,   miR-22↑, 1,   miR-224↓, 1,   miR-27a-3p↓, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-422a↑, 1,   miR-542↓, 1,   Myc↓, 2,   OCT4↓, 6,   other↓, 1,   other↑, 3,   other↝, 9,   SALL4↓, 1,   SBF2-AS1↓, 1,   sonoS↑, 1,   SOX2↓, 6,   SOX4↓, 1,   SUV39H↓, 2,   TBX15↑, 1,   TET3↑, 1,   TLE1↓, 1,   tumCV?, 6,   tumCV↓, 593,   tumCV↑, 11,   tumCV∅, 7,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 4,   c-ATF6↑, 1,   CHOP/DDIT3↑, 20,   eIF2α↑, 3,   p‑eIF2α↑, 5,   ER Stress↓, 1,   ER Stress↑, 32,   ERStress↑, 1,   GRP78/BiP↑, 16,   GRP94↑, 4,   HSF1↓, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP70/HSPA5⇅, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 4,   IRE1↑, 2,   PERK↑, 3,   p‑PERK↑, 4,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↑, 3,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 4,   ATG7↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 11,   CTSB↓, 2,   CTSD↓, 2,   LC3A↑, 1,   LC3B↑, 5,   LC3B-II↑, 2,   LC3I↑, 2,   LC3II↑, 11,   LC3s↑, 1,   MitoP↑, 3,   p62↓, 6,   p62↑, 4,   PARK2↑, 3,   SESN2↑, 1,   TumAuto↓, 4,   TumAuto↑, 41,   p‑ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   p‑ATM↑, 1,   ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   DFF45↑, 1,   DNA-PK↑, 1,   DNAdam↓, 1,   DNAdam↑, 65,   DNArepair↓, 1,   hTERT/TERT↓, 3,   Ku70/XRCC6↓, 1,   NHEJ↓, 1,   P53?, 1,   P53↓, 2,   P53↑, 57,   P53⇅, 1,   P53↝, 1,   p‑P53↑, 3,   p53 Wildtype↓, 1,   PARP↓, 5,   PARP↑, 15,   p‑PARP↑, 1,   cl‑PARP↓, 3,   cl‑PARP↑, 54,   PARP1↑, 2,   cl‑PARP1↑, 3,   PCNA↓, 14,   POLD1↓, 1,   SIRT6↑, 1,   Telomerase↓, 5,   TOP1↓, 1,   TOP2↓, 3,   TP53↑, 1,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↑, 7,   p‑γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 10,   CDK1↑, 1,   p‑CDK1↑, 1,   CDK2↓, 11,   CDK2↑, 1,   CDK4↓, 16,   CDK4↑, 1,   CDK6↓, 9,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   ChrCon↑, 2,   cycA1/CCNA1↓, 6,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 11,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 48,   CycD3↓, 3,   CycD3↑, 1,   cycE/CCNE↓, 14,   cycE1↓, 2,   E2Fs↓, 2,   Ki-67↓, 19,   mitA↑, 2,   MKI67↑, 1,   P21?, 1,   P21↓, 4,   P21↑, 35,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 13,   PLK1↓, 1,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 2,   RB1↑, 1,   p‑RB1↓, 2,   Securin↓, 1,   TumCCA?, 3,   TumCCA↓, 2,   TumCCA↑, 157,   TumCCA⇅, 1,   TumCCA∅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 2,   ALDH↓, 3,   ALDH1A1↓, 1,   Axin2↓, 1,   BMI1↓, 1,   BMPs↑, 1,   CD133↓, 5,   CD24↓, 2,   CEBPA↑, 1,   cFos↓, 2,   CSCs↓, 17,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 1,   HH↓, 3,   HMGCR↓, 1,   IGF-1?, 1,   IGF-1↓, 6,   Ki-67↓, 19,   LRP6↓, 1,   mTORC1↓, 4,   Nanog↓, 4,   Nestin↓, 2,   NOTCH↓, 3,   NOTCH1↓, 3,   NOTCH3↓, 1,   Piezo1↑, 1,   Shh↓, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG?, 2,   TumCG↓, 81,   TumCG↑, 2,   TumCG∅, 1,   TumCP↓, 116,   TumCP↑, 2,   Wnt↓, 14,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AKR1C2↓, 1,   Alix/AIP‑1↓, 1,   annexin II↓, 1,   AntiAg↑, 1,   AP-1↓, 1,   APC↑, 1,   Ca+2↓, 2,   Ca+2↑, 20,   Ca+2↝, 5,   i-Ca+2↓, 1,   i-Ca+2↑, 4,   Cal1↑, 2,   cal2↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 1,   Cofilin↓, 1,   p‑Cofilin↑, 2,   COL1↓, 1,   COL4↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 14,   EMT?, 1,   EMT↓, 31,   F-actin↓, 1,   F-actin↑, 1,   FAK↓, 3,   p‑FAK↓, 1,   Fibronectin↓, 2,   IQGAP3↓, 1,   KRAS↓, 4,   LEF1↓, 1,   MET↑, 1,   MMP1↓, 4,   MMP16↓, 1,   MMP2↓, 37,   MMP3↓, 3,   MMP7↓, 4,   MMP7∅, 1,   MMP9↓, 32,   MMP9:TIMP1↓, 1,   MMPs↓, 12,   N-cadherin↓, 8,   N-cadherin↑, 2,   PAK1↓, 2,   proline↓, 1,   Rac1↓, 2,   Rho↓, 1,   Rho↑, 1,   Slug?, 1,   Slug↓, 7,   SMAD2↓, 1,   SMAD3↓, 3,   Snail?, 1,   Snail↓, 9,   Snail↑, 1,   TET1↑, 3,   TGF-β↓, 3,   TIMP1↑, 3,   TIMP2↓, 1,   TIMP2↑, 2,   TRIB3↑, 1,   TumCA↓, 1,   TumCI↓, 78,   TumCMig↓, 98,   TumCMig↑, 1,   TumCMig⇅, 1,   TumMeta↓, 28,   TumMeta↑, 3,   Twist↓, 7,   TXNIP↑, 1,   uPA↓, 2,   Vim?, 1,   Vim↓, 12,   Vim↑, 2,   Zeb1↓, 2,   α-SMA↓, 1,   α-SMA↑, 2,   β-catenin/ZEB1↓, 24,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 27,   angioG↑, 1,   CD31/PECAM-1↓, 1,   Endoglin↑, 2,   eNOS↓, 1,   HIF-1↓, 4,   Hif1a↓, 17,   Hif1a↑, 1,   LOX1↓, 1,   NO↓, 1,   VCAM-1↓, 1,   VEGF↓, 34,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 2,   BBB↑, 1,   BBB∅, 1,   CellMemb↓, 1,   EPR↑, 4,   GLUT1↓, 5,   MMP?, 1,   MMP↓, 105,   MMP↑, 2,   MMP∅, 1,   MPT↑, 5,   NHE1↓, 1,   SLC6A3?, 1,   sonoP↑, 2,   TRPM7↓, 3,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CCR7↓, 1,   CD4+↑, 6,   CD44↓, 4,   CD8+↑, 7,   cDC2↓, 2,   COX1↓, 2,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCR3↓, 1,   CXCR4↓, 2,   DR4↑, 3,   FOXP3↑, 1,   Gal-3↓, 1,   HMGB1↓, 2,   IFN-γ↓, 2,   IL1↓, 1,   IL1↑, 1,   IL10↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 8,   IL1β↑, 1,   IL4↓, 1,   IL6↓, 21,   IL8↓, 4,   Imm↑, 10,   Inflam↓, 22,   MCP1/CCL2↓, 1,   MIP2↓, 1,   MyD88↑, 1,   NF-kB↓, 66,   NF-kB↑, 3,   NF-kB↝, 1,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 2,   NLRP3↑, 2,   p50↓, 1,   p65↓, 4,   p‑p65↓, 3,   PD-1↓, 1,   PD-L1↓, 5,   PD-L1↑, 1,   PGE2↓, 5,   PSA↓, 2,   T-Cell↑, 1,   TCF↓, 2,   Th1 response↑, 1,   TLR4↓, 3,   TLR4↑, 1,   TNF-α↓, 16,   TNF-α↑, 5,   TRAF2↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   GGT/CD224↑, 1,   pH↓, 1,   pH↑, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 3,   CYP11A1↓, 1,   DHT↓, 1,   ER-α36↓, 2,   ER-α36↝, 1,   ERβ/ESR2↑, 1,   Estro↝, 1,   EstroRS/ERS↓, 1,   HSD3B↓, 1,   PPARγ↑, 6,   RANKL↓, 1,   SRD5A1↑, 1,   StAR↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 13,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↑, 85,   CompStab↓, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1B1↓, 1,   Dose?, 2,   Dose↓, 3,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 60,   Dose∅, 6,   eff?, 2,   eff↓, 75,   eff↑, 52,   eff⇅, 1,   eff↝, 5,   eff∅, 2,   Half-Life↓, 4,   Half-Life↝, 1,   MDR1↓, 2,   MDR1↑, 1,   MRP1/ABCC1↓, 1,   MRP5↓, 1,   P-gp/ABCB1↓, 8,   RadioS↑, 19,   selectivity?, 4,   selectivity↓, 2,   selectivity↑, 120,   selectivity∅, 1,   Synergy↑, 46,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AR↓, 3,   AST↓, 2,   BRCA1↓, 2,   BRCA1↑, 1,   CRP↓, 1,   EGFR↓, 19,   p‑EGFR↓, 2,   EstroRS/ERS↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 21,   KRAS↓, 4,   LDH↓, 5,   LDH↑, 6,   Myc↓, 2,   PD-L1↓, 5,   PD-L1↑, 1,   PSA↓, 2,   TG/TAG↓, 1,   TP53↑, 1,   TRIB3↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 37,   AntiCan⇅, 1,   AntiDiabetic↑, 1,   antiNeop↑, 3,   AntiTum↑, 14,   AntiTum⇅, 1,   cardioP↑, 5,   chemoP↓, 1,   chemoP↑, 10,   chemoPv↑, 13,   ChemoSideEff↓, 2,   fatigue↓, 1,   FTO↓, 1,   hepatoP↑, 2,   Mucositis↓, 1,   neuroP↑, 5,   OS↑, 9,   Pain↓, 1,   QoL↑, 1,   radioP↑, 3,   RenoP↑, 1,   Risk↓, 3,   Sleep↑, 1,   TGFβR1↓, 1,   toxicity↓, 16,   toxicity↝, 3,   toxicity∅, 1,   TumNum↓, 1,   TumVol↓, 34,   TumVol↑, 1,   TumVol∅, 1,   TumW↓, 17,   TumW∅, 1,   Weight↑, 1,   Weight∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 8,  
Total Targets: 843

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 46,   Bil↓, 1,   Catalase↑, 14,   Fenton↓, 1,   GPx↑, 10,   GPx1↑, 1,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 15,   GSR↑, 1,   GSTs↑, 6,   HO-1↓, 1,   HO-1↑, 7,   Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 11,   MDA↓, 9,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   Nrf1↑, 1,   NRF2↑, 13,   RNS↓, 2,   ROS↓, 32,   ROS↑, 5,   ROS⇅, 1,   ROS∅, 1,   SOD?, 1,   SOD↑, 13,   SOD1↑, 1,   TAC↑, 1,   TBARS↓, 1,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 2,   VitE↓, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↓, 1,   OXPHOS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ALAT↓, 7,   AMPK↓, 1,   ATP↓, 1,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 1,   HK2↑, 1,   NAD↓, 1,   NADPH↓, 2,   PFKL↑, 1,   PFKM↑, 1,   PKM2↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   Apoptosis↑, 1,   BAX↓, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp3↓, 7,   Casp3↑, 1,   proCasp3↓, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 3,   Casp9↑, 1,   Cyt‑c↓, 2,   Fas↑, 1,   Ferroptosis↑, 1,   iNOS↓, 3,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   e-Akt↑, 1,   AMPKα↑, 1,   p‑CREB↑, 1,   ERK↑, 1,   e-ERK↑, 1,   IKKα↑, 1,   JAK2↑, 1,   PI3K↑, 1,   STAT↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   other↝, 3,   RUNX2↑, 1,   tumCV↓, 5,   tumCV↑, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 1,   P53↓, 1,   P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   cycE/CCNE↑, 1,   GADD34↓, 1,   P21↓, 1,   P21↑, 3,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   TumCG↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 1,   Ca+2↓, 1,   Cartilage↑, 1,   COL1↑, 1,   LRP1↑, 1,   MUC1↑, 1,   p‑Rac1↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCMig↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CellMemb↑, 1,   GastroP↑, 1,   GLUT1↑, 1,   IBI↑, 1,   MMP↓, 1,   MMP↑, 1,   VGSC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 7,   FOXP3↑, 1,   HMGB1↓, 1,   IFN-γ↓, 1,   IL1↓, 1,   IL10↓, 3,   IL10↑, 2,   IL17↓, 2,   IL1β↓, 6,   IL4↑, 1,   IL6↓, 8,   Imm↓, 1,   Imm↑, 2,   Inflam↓, 39,   Inflam↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   NeuroI↓, 1,   NF-kB?, 1,   NF-kB↓, 8,   NK cell↑, 1,   NLRP3↓, 3,   PGE2↓, 5,   PSA∅, 1,   RAGE↓, 1,   TNF-α↓, 12,   Treg lymp↝, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↓, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,   tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 2,   testos↑, 1,   VDR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 5,   BioAv↝, 3,   ChemoSen↑, 1,   CompStab↝, 1,   CYP2E1↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 6,   eff↓, 1,   eff↑, 6,   Half-Life↑, 1,   Half-Life↝, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALP↓, 3,   AST↓, 6,   Bil↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 2,   CEA↓, 1,   creat↓, 1,   IL6↓, 8,   LDH↓, 1,   PSA∅, 1,   RAGE↓, 1,   SpO2↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 7,   AntiArt↑, 3,   AntiCan↑, 5,   AntiDiabetic↑, 11,   antiNeop↑, 1,   AntiTum↑, 3,   Bone Healing↑, 1,   cardioP↑, 11,   chemoP↑, 5,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 2,   cough?, 1,   diuretic↑, 1,   hepatoP↑, 13,   memory↑, 3,   neuroP↑, 17,   Obesity↓, 3,   OS↑, 1,   Pain↓, 3,   RenoP↑, 2,   SoreThr?, 1,   Stress↓, 1,   toxicity↓, 21,   toxicity↑, 1,   toxicity↝, 6,   toxicity∅, 5,   Weight↑, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↑, 1,   AntiP↑, 3,   AntiViral↑, 3,   Bacteria↓, 8,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 241

Scientific Paper Hit Count for: tumCV, Cell Viability
22 Silver-NanoParticles
17 Quercetin
14 Cisplatin
14 Sulforaphane (mainly Broccoli)
14 Thymoquinone
12 Curcumin
11 Honokiol
10 doxorubicin
10 Licochalcone A
9 Dandelion Root
9 Fisetin
9 Kaempferol
9 Magnetic Fields
9 Methylsulfonylmethane
9 Phenethyl isothiocyanate
8 Betulinic acid
8 Marjoram (Origanum majorana)
7 SonoDynamic Therapy UltraSound
7 Berberine
7 Capsaicin
7 Carvacrol
7 Eugenol
7 Cynaropicrin
7 Gallic acid
7 Luteolin
7 Shikonin
6 Cynara scolymus/Globe Artichoke/Artichoke Extract
6 Allicin (mainly Garlic)
6 Radiotherapy/Radiation
6 Chrysin
6 Resveratrol
6 Emodin
6 Hyperoside
6 Ivermectin
6 Morin
5 Allyl isothiocyanate
5 Melatonin
5 5-fluorouracil
5 chaetocin
5 Crocetin
5 Formononetin
5 Ginkgetin
5 isoquercitrin
5 Licorice
5 Linalool
5 Matrine
5 Magnetic Field Rotating
5 Phycocyanin
5 Rosmarinic acid
4 Apigenin (mainly Parsley)
4 Metformin
4 Artemisinin
4 Baicalein
4 Berbamine
4 Biochanin A
4 Gemcitabine (Gemzar)
4 Benzyl isothiocyanate
4 Caffeic Acid Phenethyl Ester (CAPE)
4 Chlorogenic acid
4 Carvone
4 Eurycomanone
4 Shilajit/Fulvic Acid
4 Graviola
4 Magnolol
4 iodine
4 Juglone
4 Lycopene
4 Terpinen-4-ol / Tea Tree Oil
4 Propolis -bee glue
4 α-Santalol/Sandalwood oil
4 Silymarin (Milk Thistle) silibinin
4 Vitamin C (Ascorbic Acid)
4 Vitexin
3 Ashwagandha(Withaferin A)
3 Astaxanthin
3 Beta-Caryophyllene
3 Carnosic acid
3 chitosan
3 Selenium
3 Citric Acid
3 CUSP9
3 Chlorella (Chlorella vulgaris)
3 Dichloroacetate
3 tamoxifen
3 Echinacea
3 eicosapentaenoic acid
3 Evodiamine
3 Fucoidan
3 Gambogic Acid
3 Hibiscus sabdariffa
3 Hyperthermia
3 HydroxyTyrosol
3 Methylene blue
3 mebendazole
3 Mushroom Chaga, Inonotus obliquus
3 Nimbolide
3 Piperlongumine
3 Plumbagin
3 Parthenolide
3 Selenite (Sodium)
3 Urolithin
2 3-bromopyruvate
2 Alpha-Lipoic-Acid
2 Anethole/trans-Anethole
2 Aloe anthraquinones
2 Bacopa monnieri
2 Boswellia (frankincense)
2 Beetroot
2 brusatol
2 Caffeic acid
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Coenzyme Q10
2 Polyphenols
2 Copper and Cu NanoParticles
2 Hydroxycinnamic-acid
2 Indole-3-carbinol
2 D-limonene
2 EGCG (Epigallocatechin Gallate)
2 Garcinol
2 Ginkgolic acids
2 Ginkgo biloba
2 Geraniol
2 Helleborus niger extracts – Christmas Rose
2 Rutin
2 Isoliquiritigenin
2 Isorhamnetin
2 isoorientin
2 Lasiodin
2 SDG/lignans
2 Lutein
2 Gold NanoParticles
2 Iron
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Mushroom Maitake
2 Naringin
2 Purple Corn / Purple Maize
2 Piperine
2 salinomycin
2 polyethylene glycol
2 Selenium NanoParticles
2 Chemotherapy
2 Photodynamic Therapy
2 Aflavin-3,3′-digallate
2 Ursolic acid
2 VitK3,menadione
2 Zerumbone
1 1,8-Cineole
1 Resiquimod
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 Bevacizumab (brand Avastin)
1 borneol
1 Boron
1 α-Bisabolol / Chamomile oil
1 Bullatacin
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 hydroxychloroquine
1 Catechins
1 Cannabidiol
1 Selenate
1 Vitamin E
1 Cranberry
1 Docosahexaenoic Acid
1 Diindolylmethane
1 Disulfiram
1 Ellagic acid
1 Cannabichromene
1 Ginkgo biloba-EGb 761
1 Electrical Pulses
1 Estrogen
1 Ferulic acid
1 Fenbendazole
1 Fennel Oil/Foeniculum vulgare
1 olaparib/LYNPARZA
1 Genistein (soy isoflavone)
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Hydrogen Gas
1 HydroxyCitric Acid
1 Paclitaxel/Taxol
1 Isobavachalcone
1 Inositol
1 MCT, metronomic chemo
1 capecitabine
1 Isothiocyanates
1 itraconazole
1 L-Theanine
1 Lactobacillus
1 lambertianic acid
1 Lapachol
1 Lemongrass Extract/Citral
1 Folic Acid, Vit B9
1 MBE, Maqui berry
1 gefitinib, erlotinib
1 Modified Citrus Pectin
1 irinotecan
1 Methyl Jasmonate
1 methylseleninic acid
1 Methyl salicylate / Sweet Birch oil
1 Aspirin
1 immunotherapy
1 Magnesium
1 Mangiferin
1 magnetic nanoparticles
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Bicarbonate(Sodium)
1 Niclosamide (Niclocide)
1 Oleuropein
1 Patchouli Oil (Pogostemon cablin)
1 Phenylbutyrate
1 Propyl gallate
1 Pterostilbene
1 Perilla
1 Scoulerine
1 Sesamin
1 acetazolamide
1 triptolide
1 Triphala
1 Turmerones
1 Vitamin D3
1 Vitamin K2
1 Whole Body Vibration
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:897  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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