EMT Cancer Research Results

EMT, Epithelial-Mesenchymal Transition: Click to Expand ⟱

Source:

Type:

Biological process in which epithelial cells lose their cell polarity and cell-cell adhesion properties and gain mesenchymal traits, such as increased motility and invasiveness. This process is pivotal during embryogenesis and wound healing. Hh signaling pathway is able to regulate the EMT. Snail, E-cadherin and N-cadherin, key components of EMT; EMT-related factors, E-cadherin, N-cadherin, vimentin; The hallmark of EMT is the upregulation of N-cadherin followed by the downregulation of E-cadherin.
EMT is regulated by various signaling pathways, including TGF-β, Wnt, Notch, and Hedgehog pathways. Transcription factors such as Snail, Slug, Twist, and ZEB play critical roles in repressing epithelial markers (like E-cadherin) and promoting mesenchymal markers (like N-cadherin and vimentin).
EMT is associated with increased tumor aggressiveness, enhanced migratory and invasive capabilities, and resistance to apoptosis.

Scientific Papers found: Click to Expand⟱

3431-

TQ,

PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer

-

in-vitro,

CRC,

HCT116

21.71 µM

-

in-vitro,

CRC,

SW48

20.53 µM

Glycolysis↓, Warburg↓, HK2↓, ATP↓, NADPH↓, PI3K↓, Akt↓, TumCP↓, E-cadherin↑, N-cadherin↓, Hif1a↓, PKM2↓, GlucoseCon↓, lactateProd↓, EMT↓,

3571-

TQ,

The Role of Thymoquinone in Inflammatory Response in Chronic Diseases

-

Review,

Var,

NA

-

Review,

Stroke,

NA

*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, Synergy↑, DNAdam↑, *iNOS↓,

5911-

TV,

Thymol Isolated from Thymus vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway

-

vitro+vivo,

CRC,

NA

TumCP↓, Apoptosis↑, TumVol↓, Bax:Bcl2↑, EMT↓, TumCI↓, TumMeta↓, Wnt/(β-catenin)↓,

1139-

UA,

Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells

-

in-vitro,

Lung,

A549

TumMeta↓, AEG1↓, E-cadherin↑, N-cadherin↓, Vim↓, EMT↓,

4856-

Uro,

Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro

-

in-vitro,

NPC,

CNE1

20–60 μM UroA

34.72 μM and 44.91 μM

-

in-vitro,

NPC,

CNE2

Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,

4838-

Uro,

The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention

-

Review,

Var,

NA

BioAv↑, Inflam↓, IL6↓, IL1β↓, NOS2↓, p53 Wildtype↑, MDM2↑, Snail↓, E-cadherin↑, N-cadherin↓, Vim↓, NF-kB↓, mTOR↓, p‑Akt↓, selectivity↑, EMT↓,

4844-

Uro,

Urolithin A Inhibits Epithelial–Mesenchymal Transition in Lung Cancer Cells via P53-Mdm2-Snail Pathway

-

in-vitro,

Lung,

A549

-

in-vitro,

Lung,

H460

TumCMig↓, TumCI↓, EMT↓, Snail↓, MDM2↑, P53↑, E-cadherin↑, N-cadherin↓, Vim↓,

633-

VitC,

Diverse antitumor effects of ascorbic acid on cancer cells and the tumor microenvironment

-

Analysis,

Var,

NA

Fenton↑, ROS↑, EMT↓, DNAdam↑, PARP↑, NAD↓, ATP↓, Apoptosis↑,

1217-

VitC,

High-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition

-

in-vitro,

BC,

Bcap37

low-dose, 0.01 mM; medium-dose, 0.1 mM; high-dose, 2 mM

-

in-vitro,

BC,

MDA-MB-231

-

in-vivo,

NA,

NA

mice

TumCMig↓, E-cadherin↑, Vim↓, EMT↓,

4618-

VitD3,

Vitamin D sensitizes cervical cancer to radiation-induced apoptosis by inhibiting autophagy through degradation of Ambra1

-

in-vivo,

Cerv,

NA

Risk↓, RadioS↑, Apoptosis↑, EMT↝,

2366-

VitD3,

Vitamin D3 decreases glycolysis and invasiveness, and increases cellular stiffness in breast cancer cells

-

in-vitro,

BC,

MCF7

Glycolysis↓, tumCV↓, Apoptosis↑, mTOR↓, AMPK↑, EMT↓, E-cadherin↑, F-actin↑, Vim↓,

1816-

VitK2,

Role of Vitamin K in Selected Malignant Neoplasms in Women

-

Review,

Var,

NA

TumCP↓, TumMeta↓, TumAuto↑, Apoptosis↑, Apoptosis↑, Casp3↑, Casp7↑, ROS↑, AR↓, EMT↓, Wnt↓, MMP↓, Cyt‑c↑, NF-kB↓, cycD1/CCND1↓, TumCCA↓,

1820-

VitK3,

Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells

-

in-vitro,

CRC,

SW480

-

in-vitro,

CRC,

SW-620

selectivity↑, TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Vim↓, Zeb1↓, MMP2↓, MMP9↓, TOPflash↓, β-catenin/ZEB1↓, p300↓, cycD1/CCND1↓, TumCCA↑,

1821-

VitK3,

Menadione (Vitamin K3) induces apoptosis of human oral cancer cells and reduces their metastatic potential by modulating the expression of epithelial to mesenchymal transition markers and inhibiting migration

-

in-vitro,

Oral,

NA

-

in-vitro,

Nor,

HEK293

-

in-vitro,

Nor,

HaCaT

selectivity↑, TumCD↓, BAX↑, P53↑, Bcl-2↓, p65↓, E-cadherin↑, EMT↓, Vim↓, Fibronectin↓, TumCG↓, TumCMig↓,

7909-

VT,

Vitexin Inhibits Gastric Cancer Growth and Metastasis through HMGB1-mediated Inactivation of the PI3K/AKT/mTOR/HIF-1α Signaling Pathway

-

vitro+vivo,

GC,

NA

mice

tumCV↓, TumCMig↓, TumCI↓, EMT↓, PI3K↓, Akt↓, Hif1a↓, HMGB1↓, TumCG?,

1222-

Z,

Zinc regulates primary ovarian tumor growth and metastasis through the epithelial to mesenchymal transition

-

in-vitro,

Ovarian,

NA

EMT↑, TumCMig↑, TumCI↑, ERK↑, Akt↑,

Showing Research Papers: 351 to 366 of 366
Prev Page 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 366

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

NA↑, 1, NA?, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2, antiOx↑, 7, Catalase↓, 7, ENOX2↓, 1, Fenton↑, 1, frataxin↑, 1, GPx↓, 3, GPx1↓, 1, GPx4↓, 8, GPx4↝, 1, GSH↓, 21, GSH↑, 4, GSH/GSSG↓, 1, GSR↓, 2, GSR↑, 1, ox-GSSG↑, 1, GSTs↓, 2, GSTs↑, 1, H2O2↑, 1, HO-1↓, 8, HO-1↑, 13, Iron↑, 3, c-Iron↑, 1, Keap1↑, 1, lipid-P↓, 2, lipid-P↑, 8, MDA↓, 1, MDA↑, 4, NQO1?, 1, NQO1↓, 3, NQO1↑, 4, NRF2↓, 20, NRF2↑, 14, NRF2↝, 1, PYCR1↓, 1, RNS↑, 1, ROS?, 1, ROS↓, 20, ROS↑, 140, ROS⇅, 4, ROS↝, 2, i-ROS↓, 1, mt-ROS↑, 2, selenoP↑, 1, SOD↓, 11, SOD↑, 3, SOD1↓, 3, SOD1↑, 1, SOD2↓, 4, SOD2↑, 2, Trx↓, 1, Trx1↑, 1, TrxR↓, 2, TrxR1↓, 1, VitC↓, 1, VitE↓, 1, xCT/SLC7A11↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2, IronCh↑, 1, STEAP3↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1, CDC2↓, 6, CDC25↓, 6, compI↓, 1, compIII↓, 1, compV↓, 1, EGF↓, 6, ETC↓, 3, Insulin↓, 1, mitResp↓, 4, mitResp↑, 1, Mortalin↓, 1, mtDam↑, 13, OCR↓, 4, OXPHOS↓, 1, OXPHOS↑, 2, mt-OXPHOS↓, 1, PDH↝, 1, SIRT3↓, 1, SIRT3↑, 4,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, 5LO↓, 2, AApath↓, 1, ACADS/SCAD↓, 1, ACC↑, 1, ACLY↓, 1, p‑ACLY↓, 1, ACSL4↑, 1, ALAT↓, 4, AMPK↓, 1, AMPK↑, 22, AMPK↝, 1, p‑AMPK↑, 1, ATP↓, 15, mt-ATP↓, 1, CAIX/CA9↓, 1, ECAR↓, 1, ENO1↓, 1, FABP4↑, 1, FASN↓, 2, GAPDH↓, 1, glucoNG↓, 1, glucose↓, 1, glucose↝, 1, GlucoseCon↓, 9, GlutMet↓, 1, Glycolysis↓, 27, GSK‐3β↓, 9, GSK‐3β↑, 2, GSK‐3β↝, 1, p‑GSK‐3β↓, 8, HK1↓, 1, HK2↓, 11, HMG-CoA↓, 4, IDH1↑, 1, lactateProd↓, 9, LDHA↓, 4, LDL↓, 1, lipoGen↓, 1, NAD↓, 1, NADPH↓, 4, NADPH↑, 1, O-Glc↓, 1, PDK1 / PDPK1↓, 5, p‑PDK1 / PDPK1↓, 2, PDK3↑, 1, PDKs↓, 1, PFK↓, 1, PFK1↓, 1, PIP3↑, 1, PKM2↓, 15, PKM2↑, 1, RARα↓, 1, RARβ↑, 1, RARγ↑, 1, SIRT1↓, 10, SIRT1↑, 4, SIRT2↓, 1, SREBP1/SREBF1↓, 2, TCA↓, 1, Warburg↓, 5,

Cell Death(tgid=5) ⓘ

AIF↑, 5, APAF1↑, 3, Apoptosis↓, 6, Apoptosis↑, 124, mt-Apoptosis↑, 1, ASC↓, 1, ASC↑, 1, BAD↓, 1, BAD↑, 3, Bak↑, 7, BAX↓, 1, BAX↑, 59, BAX↝, 1, Bax:Bcl2↑, 16, Bcl-2↓, 69, Bcl-2↑, 1, Bcl-xL↓, 18, Bcl-xL↑, 1, BID↑, 4, p‑BID↓, 1, BIM↓, 1, BIM↑, 6, BNIP3↑, 2, BOK↑, 1, Casp↑, 17, Casp1↓, 3, Casp10↑, 1, Casp12↑, 1, cl‑Casp12↑, 2, cl‑Casp12↝, 1, Casp3↓, 3, Casp3↑, 71, cl‑Casp3↑, 16, Casp6↑, 1, Casp7↑, 15, Casp8↑, 14, cl‑Casp8↑, 2, Casp9↓, 1, Casp9↑, 45, cl‑Casp9↑, 5, proCasp9↓, 1, cFLIP↓, 2, Cyt‑c↓, 2, Cyt‑c↑, 42, mt-Cyt‑c↓, 1, Diablo↑, 4, DR5↑, 19, Endon↑, 1, FADD↑, 4, Fas↓, 1, Fas↑, 15, FasL↓, 1, FasL↑, 4, Ferroptosis↑, 13, GSDMD↑, 1, HEY1↓, 1, IAP1↓, 5, IAP2/BIRC3↓, 1, IAP2/BIRC3↑, 1, iNOS↓, 5, Mcl-1?, 1, Mcl-1↓, 15, Mcl-1↑, 1, p‑Mcl-1↓, 1, MDM2↓, 7, MDM2↑, 2, p‑MDM2↓, 1, NAIP↓, 1, Necroptosis↑, 1, NOXA↑, 1, p38↓, 5, p38↑, 9, p‑p38↓, 2, p‑p38↑, 1, PUMA↓, 1, PUMA↑, 2, Pyro↑, 2, RIP1↑, 1, RIP3↑, 1, survivin↓, 32, TNFR 1↑, 1, TRAIL↑, 1, TRAIL⇅, 1, TRAILR↑, 3, TumCD↓, 1, TumCD↑, 5, TUNEL↑, 1, XIAP↓, 19, YAP/TEAD↓, 4, YAP/TEAD↝, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 109, Akt↑, 4, Akt↝, 1, p‑Akt↓, 30, AKT1↓, 2, Akt2↓, 1, CIP2A↓, 1, CK2↓, 3, cMET↓, 3, cSrc↓, 1, DDIT4↑, 1, EF-1α↓, 1, EGFR↓, 31, EGFR↑, 1, p‑EGFR↓, 1, ERK↓, 28, ERK↑, 7, ERK↝, 1, p‑ERK↓, 10, ERK5↑, 1, FGFR1↓, 4, FGFR2↓, 1, FOXD3↑, 1, HER2/EBBR2↓, 7, p‑HER2/EBBR2↓, 1, HGF/c-Met↓, 1, Hippo↑, 1, Hippo↝, 1, IGF-1R↓, 1, IKKα↓, 7, IKKα↑, 1, p‑IKKα↓, 1, IκB↓, 1, p‑IκB↓, 1, JAK↓, 3, p‑JAK↓, 1, JAK1↓, 2, JAK1↑, 1, JAK2↓, 6, p‑JAK2↓, 3, p‑JAK3↓, 1, JNK↓, 5, JNK↑, 12, JNK↝, 1, p‑JNK↓, 1, p‑JNK↑, 1, LIMK1↓, 1, p‑MAP2K1/MEK1↓, 1, MAPK↓, 28, MAPK↑, 9, MAPK↝, 1, p‑MAPK↓, 1, MARK4↓, 1, MEK↓, 4, MKK4↓, 1, mTOR↓, 63, mTOR↝, 1, p‑mTOR↓, 6, mTORC2↓, 2, p70S6↓, 1, P70S6K↓, 2, P90RSK↓, 2, PDGFR-BB↓, 1, PDGFRA↓, 1, PI3K↓, 94, PI3K↝, 1, p‑PI3K↓, 7, PI3K/Akt↓, 4, PI3k/Akt/mTOR↓, 1, PKA↓, 1, PKCδ↓, 5, PTEN↓, 2, PTEN↑, 19, Raf↓, 4, c-Raf↓, 1, RAS↓, 4, RET↓, 1, p‑S6K↓, 1, SHP1↑, 1, Sp1/3/4↓, 12, Src↓, 3, p‑Src↓, 1, STAT↓, 2, p‑STAT2↓, 1, STAT3↓, 54, STAT3↑, 1, STAT3↝, 1, p‑STAT3↓, 12, p‑STAT3↑, 2, STAT6↓, 1, p‑STAT6↓, 1, TSC2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1, ATF4↓, 1, ATF4↑, 10, p‑ATF4↝, 1, CBP↓, 1, cJun↓, 7, cJun↑, 1, cMyc↓, 29, p‑cMyc↑, 1, DNMT1↓, 8, DNMT3A↓, 5, DNMTs↓, 2, EZH2↓, 6, FOXM1↓, 3, FOXO1↓, 3, FOXO3↓, 2, FOXO3↑, 4, p‑FOXO3↓, 1, FOXO4↓, 2, H3↓, 2, H3↑, 2, ac‑H3↑, 2, H3K27ac↓, 1, H4↓, 1, H4↑, 1, ac‑H4↑, 1, HATs↓, 2, HATs↑, 3, HDAC↓, 14, HDAC1↓, 3, HDAC10↓, 1, HDAC2↓, 2, HDAC3↓, 2, HDAC4↓, 2, HES1↓, 3, HOTAIR↓, 1, miR-107↑, 1, miR-10a-5p↝, 1, miR-133a-3p↑, 1, miR-139-5p↑, 1, miR-141↑, 1, miR-145↑, 1, miR-155↓, 1, miR-155↝, 1, miR-19b↓, 1, miR-200b↑, 1, miR-200c↑, 1, miR-203↑, 1, miR-205↑, 1, miR-21↓, 4, miR-21↑, 1, miR-218↑, 1, miR-224↓, 1, miR-25-5p↓, 1, miR-27a-3p↓, 1, miR-29b↑, 1, miR-301a-3p↓, 1, miR-339-5p↝, 1, miR-340↓, 1, miR-34a↓, 3, miR-34a↑, 4, miR-34a↝, 1, miR-34b-5p↑, 1, miR-384↑, 2, miR-422a↑, 1, MTA2↓, 1, Myc↓, 2, n-MYC↓, 1, NDRG1↑, 1, OCT4↓, 18, other↓, 3, other↑, 4, other↝, 6, PAX2↓, 1, PhotoS↑, 1, SOX2↓, 9, SOX4↓, 4, SOX9?, 1, SOX9↓, 1, TCF-4↓, 2, TFE3↑, 1, tumCV↓, 31, ZBTB10↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 16, p‑CHOP/DDIT3↝, 1, cl‑CHOP/DDIT3↑, 1, eIF2α↓, 1, eIF2α↑, 3, p‑eIF2α↑, 4, p‑eIF2α↝, 1, ER Stress↑, 32, GRP78/BiP↓, 2, GRP78/BiP↑, 12, HSF1↓, 1, HSP27↓, 6, HSP70/HSPA5↓, 5, HSP70/HSPA5↑, 1, HSP90↓, 11, IRE1↑, 5, PDI↑, 1, PERK↑, 7, p‑PERK↝, 1, Proteasome↓, 1, SERPINH1/HSP47↓, 1, UPR↓, 1, UPR↑, 3, XBP-1↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2, ATG7↑, 1, Beclin-1/ATG6↓, 2, Beclin-1/ATG6↑, 9, CTSB↓, 2, CTSD↓, 2, LC3‑Ⅱ/LC3‑Ⅰ↓, 1, LC3B-II↑, 2, LC3II↓, 2, LC3II↑, 10, LC3s↓, 1, lysoMP↑, 1, p62↓, 3, p62↑, 2, SESN2↑, 1, TumAuto↑, 28,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2, BRCA1↑, 1, BRCA1↝, 1, p‑BRCA1↑, 1, DFF45↓, 1, DFF45↑, 2, DNAdam↑, 33, DNArepair↓, 1, ERCC1↓, 1, ERCC3↑, 1, m-FAM72A↓, 1, hTERT/TERT↓, 9, MGMT↓, 1, p16↑, 2, P53?, 1, P53↓, 1, P53↑, 55, P53↝, 1, p‑P53↑, 1, ac‑P53↑, 1, p53 Wildtype↑, 1, p53 Wildtype∅, 1, PARP↓, 1, PARP↑, 15, cl‑PARP↑, 25, PARP1↑, 2, PCNA↓, 21, PCNA↑, 1, POLD1↓, 1, SIRT6↓, 1, Telomerase↓, 9, TOP1?, 1, TOP1↓, 6, TOP2↓, 4, TP53↑, 2, TRF2↓, 1, XRCC1↓, 1, γH2AX↑, 7,

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1, CDK1↓, 9, CDK1↑, 1, CDK2↓, 25, CDK2↑, 2, CDK4↓, 29, CDK4↑, 1, p‑CDK4↓, 1, CDK6↓, 10, CDK6↑, 1, CDK8↓, 1, CDKN1C/p57↑, 1, CHK1↓, 1, p‑CHK1↑, 1, Chk2↓, 1, p‑Chk2↑, 1, cycA1/CCNA1↓, 3, cycA1/CCNA1↑, 2, CycB/CCNB1↓, 14, CycB/CCNB1↑, 2, cycD1/CCND1↓, 48, cycD1/CCND1↑, 1, p‑cycD1/CCND1↓, 1, cycE/CCNE↓, 9, E2Fs↓, 1, Ki-67↓, 22, MAD↓, 1, P21?, 1, P21↓, 3, P21↑, 33, p27/CDKN1B↓, 1, p27/CDKN1B↑, 14, pRB↓, 1, p‑pRB↓, 2, RB1↓, 1, RB1↑, 2, p‑RB1↓, 3, TumCCA↓, 4, TumCCA↑, 105,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 7, ALDH1A1↓, 6, AXIN1↓, 1, AXIN1↑, 1, BMI1↓, 1, BMP2↓, 1, BMPs↑, 1, CD133↓, 15, CD133↑, 1, CD24↓, 1, CD34↓, 1, CDX2↓, 1, CEBPB↓, 1, cFos↓, 7, cFos↑, 1, cMYB↓, 1, CSCs↓, 69, CSCsMark↓, 2, Diff↓, 2, Diff↑, 1, EIF4E↓, 1, FGF↓, 2, FGF↑, 1, Gli↓, 1, Gli1↓, 13, GREM1↓, 1, HH↓, 15, HH↝, 1, IGF-1↓, 1, IGF-2↓, 1, IGFBP3↓, 1, IGFBP3↑, 2, Ki-67↓, 22, Let-7↓, 1, Let-7↑, 2, LRP6↓, 3, p‑LRP6↓, 1, MSCmark↓, 1, mTORC1↓, 4, p‑mTORC1↓, 1, Nanog↓, 17, Nestin↓, 3, NICD↓, 1, NKD2↑, 1, NOTCH↓, 18, NOTCH↑, 1, NOTCH1↓, 18, NOTCH1↑, 3, NOTCH1↝, 1, NOTCH3↓, 3, p300↓, 2, Pirin↓, 1, PTCH1↓, 4, PTCH2↓, 1, SFRP5↑, 1, Shh↓, 13, Smo↓, 6, p‑STAT1↓, 1, Sufu↓, 1, TAZ↓, 1, TOPflash↓, 1, TumCG?, 2, TumCG↓, 62, TumCG↑, 2, TumCP?, 1, TumCP↓, 112, TumCP↑, 3, tyrosinase↓, 1, WDR72↓, 1, Wnt↓, 44, Wnt/(β-catenin)↓, 7,

Migration(tgid=13) ⓘ

ACTA2↓, 1, AEG1↓, 2, AEG1↑, 1, annexin II↓, 1, AntiAg↓, 1, AntiAg↑, 1, AP-1↓, 7, AP-1↝, 1, AXL↓, 2, CA↓, 1, Ca+2↓, 1, Ca+2↑, 21, Ca+2↝, 2, i-Ca+2↑, 1, CAFs/TAFs↓, 2, cal2↑, 1, Cdc42↓, 1, Chl↑, 1, Cofilin↓, 1, COL1↓, 1, COL1A1↓, 1, COL3A1↓, 1, CTNNB1↓, 1, E-cadherin↓, 19, E-cadherin↑, 123, EM↑, 2, EMT?, 1, EMT↓, 349, EMT↑, 7, EMT↝, 2, EpCAM↓, 1, F-actin↓, 2, F-actin↑, 1, FAK↓, 16, FAK↑, 1, p‑FAK↓, 3, fascin↓, 1, Fibronectin↓, 11, Galectin-9↓, 1, GIT1↓, 1, GLI2↓, 3, IQGAP3↓, 1, ITGA5↓, 2, ITGA5↑, 1, ITGB1↓, 7, ITGB1↑, 1, ITGB3↓, 1, ITGB6↓, 1, LAMA5↑, 1, LAMs↓, 2, LEF1↓, 4, MALAT1↓, 4, MET↓, 2, MET↑, 1, p‑MET↓, 2, MMP-10↓, 2, MMP1↓, 4, MMP13↓, 3, MMP16↓, 2, MMP2↓, 97, MMP2↝, 1, MMP3↓, 6, MMP7↓, 7, MMP9↓, 99, MMP9↑, 2, MMP9↝, 1, MMPs↓, 28, MUC1↑, 1, MUC4↓, 1, N-cadherin↓, 87, PAK1↓, 1, p‑pax↓, 1, PDGF↓, 5, PIR↓, 1, Rac1↓, 3, RHBDD1↓, 1, Rho↓, 6, ROCK1↓, 9, Slug?, 1, Slug↓, 41, Smad1↓, 4, Smad1↝, 1, SMAD2↓, 5, p‑SMAD2↓, 10, SMAD3↓, 7, p‑SMAD3↓, 8, SMAD4↓, 2, Snail?, 2, Snail↓, 75, Snail↑, 2, STAC2↓, 1, TET1↓, 1, TET1↑, 3, TGF-β↓, 31, TGF-β↑, 1, TGF-β↝, 1, TGF-β1↓, 3, TIMP1↑, 6, TIMP2↓, 2, TIMP2↑, 2, TRIB3↑, 2, TSP-1↑, 4, TumCA↓, 2, TumCI↓, 128, TumCI↑, 3, TumCMig↓, 129, TumCMig↑, 3, TumMeta↓, 77, TumMeta↑, 5, Twist↓, 30, Twist↑, 2, Tyro3↓, 1, uPA↓, 22, uPAR↓, 2, Vim?, 1, Vim↓, 103, Vim↑, 3, Zeb1↓, 32, Zeb1↑, 2, ZEB2↓, 2, ZEB2↑, 2, α-SMA↓, 3, α-SMA↑, 1, α-tubulin↓, 1, β-catenin/ZEB1↓, 65, β-catenin/ZEB1↑, 2, p‑β-catenin/ZEB1↓, 1, cl‑β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 64, angioG↑, 2, CD31/PECAM-1↓, 3, eNOS↓, 3, HIF-1↓, 5, Hif1a↓, 49, Hif1a↑, 1, Hif1a↝, 1, NO↓, 1, NO↑, 1, NO↝, 1, TXA2↓, 1, VEGF↓, 76, VEGFR1↓, 1, VEGFR2/KDR/Flk1↓, 14,

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1, BBB↑, 4, CLDN1↓, 6, CLDN1↑, 1, CLDN2↓, 1, CLDN7↑, 1, EPR↑, 1, GLUT1↓, 6, GLUT2↓, 1, MMP↓, 62, MMP↑, 1, MPT↑, 4, NHE1↓, 1, TRPV2↑, 1, ZO-1↓, 1, ZO-1↑, 6,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1, CD25+↓, 1, CD4+↓, 2, CD4+↑, 1, CD44↓, 18, CD8+↑, 4, COX1↓, 2, COX2/PTGS2↓, 47, COX2/PTGS2↑, 1, COX2/PTGS2↝, 1, CXCL12↓, 4, CXCL16↓, 1, CXCR4↓, 10, DR4↑, 3, FOXP3↑, 1, FoxP3+↓, 1, HMGB1↓, 6, ICAM-1↓, 2, IFN-γ↓, 2, IFN-γ↑, 2, Igs↑, 1, IL1↓, 4, IL10↓, 4, IL12↓, 1, IL12↑, 1, IL18↓, 2, IL1β↓, 13, IL2↓, 2, IL2↑, 4, IL4↓, 2, IL6↓, 32, IL6↑, 1, IL8↓, 7, Imm↑, 9, Imm↝, 3, Inflam↓, 22, IRAK1↓, 1, M2 MC↓, 2, MCP1/CCL2↓, 4, MCT1↓, 1, MDSCs↓, 1, NF-kB↓, 101, NF-kB↑, 4, NF-kB↝, 1, p‑NF-kB↓, 2, p‑NF-kB↑, 2, NK cell↑, 3, NLRP3↓, 3, p50↓, 1, p65↓, 6, p65↑, 1, p‑p65↓, 5, PD-1↓, 4, PD-L1↓, 9, PD-L2↓, 1, PGE2↓, 19, PSA↓, 4, RAGE↓, 1, SOCS-3↓, 1, T-Cell↑, 1, TCF↓, 5, TCF7/TCF1↓, 2, Th1 response↑, 1, TILs↑, 1, TIM-3↓, 1, TLR4↓, 3, TNF-α↓, 23, TNF-α↑, 1, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1, IM↓, 1, pH↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

MAOA↓, 1, PTN↓, 1,

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1, XO↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1, AhR↓, 2, AR↓, 12, ER-α36↓, 1, ER-α36↝, 1, FGF21↓, 1, PPARα↓, 1, PPARα↑, 2, PPARα↝, 1, PPARγ↓, 3, PPARγ↑, 2,

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B10↓, 1, BioAv↓, 26, BioAv↑, 26, BioAv↝, 7, ChemoSen↓, 1, ChemoSen↑, 111, ChemoSen⇅, 1, CompStab↓, 2, CompStab↑, 2, CompStab↝, 1, CYP1A1↓, 2, CYP1A1↑, 2, CYP1A2↑, 1, CYP2A3/CYP2A6↓, 1, CYP2E1↑, 1, CYP3A4↓, 1, Dose?, 1, Dose↓, 3, Dose↑, 4, Dose↝, 19, Dose∅, 6, DrugR↓, 1, eff↓, 15, eff↑, 38, eff↝, 6, eff∅, 2, GSTA1↓, 1, GSTA1↑, 1, Half-Life↓, 8, Half-Life↑, 1, Half-Life↝, 7, Half-Life∅, 1, MDR1↓, 7, MRP1/ABCC1↓, 2, MRP1/ABCC1↝, 1, P-gp/ABCB1↓, 15, P450↓, 4, RadioS↑, 37, selectivity?, 1, selectivity↑, 38, Synergy↑, 83,

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1, ALAT↓, 4, ALB↑, 1, ALP↓, 3, AR↓, 12, AST?, 1, AST↓, 2, BRCA1↑, 1, BRCA1↝, 1, p‑BRCA1↑, 1, CA125↓, 1, CEA↓, 1, CRP↓, 2, DBIL↓, 1, E6↓, 3, E7↓, 3, EGFR↓, 31, EGFR↑, 1, p‑EGFR↓, 1, EZH2↓, 6, Ferritin↓, 2, FOXM1↓, 3, HER2/EBBR2↓, 7, p‑HER2/EBBR2↓, 1, hTERT/TERT↓, 9, IBIL↓, 1, IL6↓, 32, IL6↑, 1, IRes↓, 1, LDH↓, 5, LDH↑, 3, Maspin↑, 1, Myc↓, 2, NOS2↓, 1, NSE↓, 1, PD-L1↓, 9, PSA↓, 4, RAGE↓, 1, TBIL↓, 1, TG/TAG↓, 1, TP53↑, 2, TRIB3↑, 2,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 24, antiNeop↑, 1, AntiTum↓, 2, AntiTum↑, 15, cachexia↓, 2, cardioP↑, 6, chemoP?, 1, chemoP↑, 11, chemoPv↑, 10, ChemoSideEff↓, 4, fatigue↓, 1, hepatoP↑, 6, neuroP↑, 5, OS↑, 12, Pain↓, 1, PFS↑, 1, Pin1↓, 2, QoL↑, 3, radioP↑, 2, RenoP↑, 4, Risk↓, 6, Symptoms∅, 1, toxicity?, 1, toxicity↓, 8, toxicity↑, 4, toxicity↝, 7, toxicity∅, 2, TumVol↓, 15, TumW↓, 6,

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1, GutMicro↑, 2, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,
Total Targets: 958

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2, antiOx↑, 43, Catalase↑, 18, DPPH↓, 1, GPx↓, 1, GPx↑, 13, GPx1↑, 1, GPx4↑, 1, GSH↑, 16, GSR↑, 2, GSTs↑, 7, HDL↓, 1, HDL↑, 1, HO-1?, 1, HO-1↑, 8, i-Iron↓, 1, Keap1↓, 1, lipid-P↓, 11, MDA↓, 13, MDA↑, 1, MPO↓, 2, NQO1↑, 1, NRF2↓, 1, NRF2↑, 20, Prx↑, 1, RNS↓, 1, ROS?, 1, ROS↓, 56, SOD↓, 1, SOD↑, 18, SOD1↑, 2, SOD2↑, 2, TAC↑, 1, TrxR↑, 1, uricA↓, 1, xCT/SLC7A11↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1, ALAT↓, 6, AMPK↓, 1, AMPK↑, 3, ATP↓, 1, DGAT1↓, 1, FASN↓, 1, glucose↓, 2, GlucoseCon↑, 1, GSK‐3β↓, 1, LDHA↑, 1, LDL↓, 2, lipidLev↓, 1, NAD↓, 1, NAD↑, 1, PKM2↓, 1, PLA2↓, 1, SIRT1↑, 4,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1, BAX↓, 2, Bcl-2↓, 1, Casp↓, 1, Casp3?, 1, Casp3↓, 4, Casp9↓, 2, Cyt‑c↓, 2, Ferroptosis↓, 1, iNOS↓, 4, TUNEL↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2, Akt↑, 4, Akt↝, 1, p‑Akt↓, 1, ERK↑, 1, p‑ERK↓, 1, JNK↓, 1, JNK↑, 1, MAPK↓, 1, mTOR↓, 1, mTOR↑, 2, p‑mTOR↓, 1, p‑P70S6K↓, 1, PI3K↓, 1, PI3K↑, 4, PTEN↑, 1, STAT3↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2, ATF4↓, 1, p‑cMyc↑, 1, HDAC↓, 1, HDAC3↓, 1, other↝, 2, RUNX2↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, ER Stress↓, 1, HSP70/HSPA5↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 4, LC3II↓, 1, p62↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2, P53↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1, Ki-67↓, 1, P21↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1, Ki-67↓, 1, tyrosinase↓, 1,

Migration(tgid=13) ⓘ

Ca+2↓, 1, COL1↓, 3, COL1↑, 1, COL3A1↓, 1, E-cadherin↑, 4, EMT↓, 7, EMT↑, 2, Fibronectin↓, 1, MMP13↓, 2, MMP2↓, 1, MMP9↓, 2, Smad7↑, 2, Snail↑, 1, TGF-β↓, 3, TGF-β1↓, 1, TIMP1↓, 1, TregCell↑, 1, Twist↑, 1, Vim↓, 4, Vim↑, 1, α-SMA↓, 6, β-catenin/ZEB1↓, 1, β-catenin/ZEB1↝, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1, Hif1a↓, 2, NO↓, 4, NO↑, 1, VEGF↓, 1, VEGF↑, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3, GLUT2↑, 1, GLUT3↑, 1, GLUT4↑, 1, MMP↑, 3, TRPC1↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 10, HMGB1↓, 1, ICAM-1↓, 1, IFN-γ↓, 3, IFN-γ↑, 1, IL10↓, 3, IL10↑, 1, IL17↓, 3, IL18↓, 1, IL1β↓, 12, IL2↓, 1, IL2↑, 1, IL23↓, 1, IL4↓, 1, IL4↑, 1, IL5↓, 2, IL6↓, 14, IL8↓, 3, Imm↓, 1, Imm↑, 3, Inflam?, 2, Inflam↓, 43, IRF3↓, 1, LPS↓, 1, MCP1/CCL2↓, 1, MyD88↓, 1, NF-kB↓, 17, NLRP3↓, 2, PGE2↓, 8, RAGE↓, 1, SOCS-3↓, 1, TLR2↓, 1, TLR4↓, 5, TNF-α↓, 17,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 4, BDNF↓, 1, BDNF↑, 1, GABA↑, 1, MAOA↓, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, Aβ↓, 9, BACE/β-secretase↓, 2, p‑tau↓, 2,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1, BNP↓, 1, PPARα↝, 1, p‑PPARγ↓, 1, TSHR↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 24, BioAv↑, 8, BioAv↝, 3, CYP2E1↓, 1, Dose↑, 1, Dose↝, 3, eff↑, 3, GSTA1↑, 1, Half-Life↝, 6, Half-Life∅, 1, P450↓, 1, Synergy↑, 3,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6, AST↓, 7, BMD↑, 1, BP↓, 1, BUN↓, 1, creat↓, 1, CRP↓, 2, IL6↓, 14, LDH↓, 2, RAGE↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1, antiAll↑, 5, AntiArt↑, 2, AntiCan↑, 5, AntiDiabetic↑, 10, AntiTum↓, 1, AntiTum↑, 1, cardioP↑, 19, chemoP↑, 2, chemoPv↑, 5, cognitive↑, 4, diuretic↑, 1, hepatoP↑, 19, Learn↑, 1, memory↑, 6, motorD↑, 1, Mucositis↓, 2, neuroP↑, 34, Obesity↓, 2, PDE4↓, 1, radioP↑, 2, RenoP↑, 5, Stroke↓, 2, toxicity↓, 15, toxicity↑, 1, toxicity↝, 4, toxicity∅, 2, Wound Healing↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2, AntiFungal↑, 1, AntiViral↑, 2, Bacteria↓, 4, GutMicro↑, 5, GutMicro↝, 1, Sepsis↓, 2,
Total Targets: 244

Scientific Paper Hit Count for: EMT, Epithelial-Mesenchymal Transition

19 Curcumin
17 Resveratrol
16 Quercetin
13 Honokiol
13 Luteolin
10 Sulforaphane (mainly Broccoli)
9 Ashwagandha(Withaferin A)
9 EGCG (Epigallocatechin Gallate)
9 Fisetin
9 Thymoquinone
7 Kaempferol
6 Astragalus
6 Berberine
6 Matrine
6 Metformin
6 Piperine
6 Rosmarinic acid
5 Apigenin (mainly Parsley)
5 Betulinic acid
5 Chrysin
5 Emodin
5 Eugenol
5 Silymarin (Milk Thistle) silibinin
4 Alpha-Lipoic-Acid
4 Baicalein
4 Propolis -bee glue
4 Chlorogenic acid
4 Diindolylmethane
4 Inositol
4 Morin
4 Pterostilbene
4 Shikonin
3 Artemisinin
3 Atorvastatin
3 5-fluorouracil
3 Cyclopamine
3 salinomycin
3 Genistein (soy isoflavone)
3 Ferulic acid
3 Fucoidan
3 Garcinol
3 HydroxyTyrosol
3 Lycopene
3 Magnolol
3 Melatonin
3 Nimbolide
3 Piperlongumine
3 Urolithin
2 Anethole/trans-Anethole
2 Cisplatin
2 Astaxanthin
2 Beta-Caryophyllene
2 brusatol
2 Capsaicin
2 Cannabidiol
2 Celecoxib
2 Centella asiatica / Gotu kola → asiaticoside
2 Crocetin
2 Radiotherapy/Radiation
2 Deguelin
2 Dandelion Root
2 Disulfiram
2 Ellagic acid
2 Sorafenib (brand name Nexavar)
2 Paclitaxel/Taxol
2 Ginkgetin
2 Grapeseed extract
2 phytic acid, Inositol hexakisphosphate
2 Isoliquiritigenin
2 isoflavones
2 isoorientin
2 isoquercitrin
2 Ivermectin
2 Juglone
2 Licorice
2 Lactoferrin/Talactoferrin
2 Naringin
2 Phenethyl isothiocyanate
2 Vitamin C (Ascorbic Acid)
2 Vitamin D3
2 VitK3,menadione
1 1,8-Cineole
1 Anthocyanins
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Aspirin
1 Baicalin
1 Berbamine
1 Biochanin A
1 Brucea javanica
1 Boron
1 Carnosic acid
1 Caffeic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cucurbitacin
1 Oxaliplatin
1 Dichloroacetate
1 Docosahexaenoic Acid
1 immunotherapy
1 Copper and Cu NanoParticles
1 Ginkgo biloba-EGb 761
1 Eurycomanone
1 Cinnamon
1 Evodiamine
1 Shilajit/Fulvic Acid
1 Gallic acid
1 Ginkgolide B
1 Proanthocyanidins
1 Hydrogen Gas
1 Chemotherapy
1 Hydroxycinnamic-acid
1 Hyperoside
1 Isovitexin
1 methotrexate
1 Lutein
1 mebendazole
1 MCT, metronomic chemo
1 Magnetic Fields
1 Lemon Balm/Melissa officinalis
1 Myricetin
1 Niclosamide (Niclocide)
1 Oleocanthal
1 Plumbagin
1 Psoralidin
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Selenium
1 Selenate
1 Gemcitabine (Gemzar)
1 Selenite (Sodium)
1 statins
1 Citric Acid
1 Terpinen-4-ol / Tea Tree Oil
1 Thymol-Thymus vulgaris
1 Ursolic acid
1 Vitamin K2
1 Vitexin
1 Zinc

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:96  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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