Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
5618- NaHCO3,    Association between sodium bicarbonate consumption and human health: A systematic review
- Review, Nor, NA
*toxicity↓,
5617- NaHCO3,    Microenvironmental alkalization promotes the therapeutic effects of MSLN-CAR-T cells
- vitro+vivo, NA, NA
Imm↑, eff↑, pH↑,
5616- NaHCO3,  DCA,    Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer
- vitro+vivo, BC, MDA-MB-231
OS↑, e-pH↑, TumMeta↓, eff↝, TumCG↝,
5615- NaHCO3,  immuno,    pH-Responsive Nanoparticles for Cancer Immunotherapy: A Brief Review
- Review, Var, NA
eff↑, eff↑, pH↑,
5614- NaHCO3,    Targeting the Acidic Tumor Microenvironment: Unexpected Pro-Neoplastic Effects of Oral NaHCO3 Therapy in Murine Breast Tissue
- in-vivo, BC, NA
e-pH↑, TumCG↝, TumCP↑,
5613- NaHCO3,    The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Acid-Mediated Invasion
- Study, Var, NA
pH↑, TumCG↓, TumCI↓, selectivity↑,
5612- NaHCO3,  immuno,    Neutralization of tumor acidity improves anti-tumor responses to immunotherapies
- vitro+vivo, Var, B16-F10
Imm↑, eff↑, e-pH↑, TumCG↓, TumMeta↓, eff↑,
5599- NaHCO3,    Acidity generated by the tumor microenvironment drives local invasion
- in-vivo, BC, MDA-MB-231 - in-vitro, CRC, HCT116
e-pH↑, TumCG↓, TumCI↓, Dose↝,
5610- NaHCO3,  doxoR,    Sodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin
- vitro+vivo, BC, 4T1
pH↑, Imm↑, eff↑, ChemoSen↑, TumVol↓, eff↑,
5609- NaHCO3,    Alkalization of cellular pH leads to cancer cell death by disrupting autophagy and mitochondrial function
- in-vitro, Var, NA
eff↑, e-pH↑, MMP↓, OXPHOS↝, AMP↑, TumAuto↑, MPT↑, mtDam↑,
5608- NaHCO3,    Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism
- Study, Var, NA
TumCG↓, TumMeta↓, e-pH↑, Pyro↑, Imm↑, Na+↑,
5607- NaHCO3,    Does Baking Soda Function as a Magic Bullet for Patients With Cancer? A Mini Review
- Review, Var, NA
AntiCan↑, e-pH↑, TumMeta↓, TumCI↓, TumCG↓, CD8+↑, NK cell↑, Remission↑, eff↑, ChemoSen↑, ChemoSen↓,
5606- NaHCO3,    Effects of Alkalization Therapy on Chemotherapy Outcomes in Metastatic or Recurrent Pancreatic Cancer
- Trial, PC, NA
Dose↝, OS↑, eff↑,
5605- NaHCO3,    A nonrandomized cohort and a randomized study of local control of large hepatocarcinoma by targeting intratumoral lactic acidosis
- Trial, HCC, NA
eff↑, Dose↝, other↓, OS↑, toxicity↓, AntiCan↓,
5604- NaHCO3,    Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity
- vitro+vivo, Melanoma, B16-BL6 - in-vitro, BC, 4T1
eff↑, eff↑, TumMeta↓, pH↑, CaMKII ↑, CREB↑, PGC-1α↑, AntiTum↑, Imm↑, CD8+↑, TAMS↑,
5603- NaHCO3,  immuno,    Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors
- in-vitro, BC, MCF-7 - in-vitro, PC, MIA PaCa-2 - in-vitro, GBM, U87MG
eff↑, e-pH↑, PD-L1↓,
5602- NaHCO3,  immuno,    Immunotherapy Enhancement by Targeting Extracellular Tumor pH in Triple-Negative Breast Cancer Mouse Model
- in-vivo, BC, 4T1
eff↑, TumCG↓, OS↑, e-pH↑, IFN-γ↑, IL2↑, IL12↑, Dose↝, PD-L1↓,
5601- NaHCO3,    Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents
- vitro+vivo, Var, NA
e-pH↑, ChemoSen↑,
5600- NaHCO3,    Acidosis and Cancer: from Mechanism to Neutralization
- Review, Var, NA
e-pH↑, TumCG↝, eff↑,
3759- NarG,  RT,  CGA,  RosA,    Polyphenols as acetylcholinesterase inhibitors: Structural specificity and impact on human disease
- Review, AD, NA
*AChE↓, *other↓, *other↓,
1311- NarG,  Rad,    Naringenin sensitizes lung cancer NCI-H23 cells to radiation by downregulation of akt expression and metastasis while promoting apoptosis
- in-vitro, Lung, H23
tumCV↓, ROS↑, Casp3↑, p‑Akt↓, Akt↓, MMP2↓, P21↓,
1798- NarG,    Naringenin: A potential flavonoid phytochemical for cancer therapy
- Review, NA, NA
*Inflam↓, *antiOx↓, neuroP↑, hepatoP↑, AntiCan↑, Apoptosis↑, TumCCA↑, angioG↓, ROS↝, SOD↑, TGF-β↓, Treg lymp↓, IL1β↓, *BioAv↝, ChemoSen↑, cardioP↑,
1797- NarG,    Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway
- in-vitro, BC, MDA-MB-231
TumCG↓, β-catenin/ZEB1↓, AntiTum↑, Apoptosis↑, TumCCA↑, P21↑, survivin↓,
1808- NarG,    Intake of flavonoids and lung cancer
- Analysis, NA, NA
AntiCan↑, CYP1A1↓,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, NA, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
1806- NarG,    Naringin: Nanotechnological Strategies for Potential Pharmaceutical Applications
- Review, NA, NA
Inflam↓, antiOx↓, AntiCan↑, BioAv↓, BioAv↓, BioAv↑, INF-γ↓, IL6↓, TNF-α↓, IL10↑, CRP↓,
1805- NarG,    Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota
- in-vitro, Ovarian, A2780S - in-vivo, NA, NA
TumCP↓, TumCMig↓, PI3K↓, TumVol↓, TumW↓, BioAv↑, GutMicro↑, Dose∅, eff↑, EGFR↓, cycD1/CCND1↓, toxicity∅,
1804- NarG,    Beneficial effects of citrus flavanones naringin and naringenin and their food sources on lipid metabolism: An update on bioavailability, pharmacokinetics, and mechanisms
- Review, NA, NA
GutMicro↝, BioAv↝,
1803- NarG,    Naringin and naringenin as anticancer agents and adjuvants in cancer combination therapy: Efficacy and molecular mechanisms of action, a comprehensive narrative review
- Review, Var, NA
JAK↓, STAT↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, COX2↓, NOTCH↓, TumCCA↑,
1802- NarG,  ATV,    Bioenhancing effects of naringin on atorvastatin
- in-vivo, Nor, NA
BioEnh↑, LDL↓, P450↓, P-gp↓,
1801- NarG,    A Narrative Review on Naringin and Naringenin as a Possible Bioenhancer in Various Drug-Delivery Formulations
- Review, Var, NA
AntiCan↓, CYP19↓, PI3K↓, Akt↓, TumAuto↑, eff↑, BioEnh↑,
1800- NarG,    Naringenin
- Human, Nor, NA
CYP19↓,
1799- NarG,    Naringenin as potent anticancer phytocompound in breast carcinoma: from mechanistic approach to nanoformulations based therapeutics
- Review, NA, NA
TumCCA↑, BioAv↑, Half-Life∅, TNF-α↓, Casp8↑, BAX↑, Bak↑, EGF↓, mTOR↓, PI3K↓, ERK↓, Akt↓, NF-kB↓, VEGF↓, angioG↓, antiOx↑, EMT↓, OS↑, MAPK↓, ChemoSen↑, MMP9↓, MMP2↓, ROS↑, ROS↑, GSH↓, Casp3↑, ROS↑,
1015- NarG,    Naringin induces endoplasmic reticulum stress-mediated apoptosis, inhibits β-catenin pathway and arrests cell cycle in cervical cancer cells
- in-vitro, Cerv, SiHa - in-vitro, Cerv, HeLa - in-vitro, Cerv, C33A
ER Stress↑, p‑eIF2α↑, CHOP↑, PARP1↑, Casp3↑, β-catenin/ZEB1↓, GSK‐3β↓, p‑β-catenin/ZEB1↓, p‑GSK‐3β↓, TumCCA↑, P21↑, p27↑,
1129- NarG,    Naringenin Attenuated Prostate Cancer Invasion via Reversal of Epithelial-to-Mesenchymal Transition and Inhibited uPA Activity
- in-vitro, Pca, PC3
E-cadherin↓, Vim↓, Snail↓, Twist↓, EMT↓, uPA↓,
928- NarG,  PacT,    Bioenhancers from mother nature and their applicability in modern medicine
- Review, Nor, NA
*BioEnh↑,
981- NarG,  QC,    Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer
- in-vivo, NA, NA
TumVol↓, CYP19↓,
4223- NarG,    Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia–Reperfusion Model of Rats
- in-vivo, Stroke, NA
*neuroG↑, *BDNF↑, *motorD↑,
4224- NarG,    The Effect of Naringin on Cognitive-Behavioral Functions, CREB/BDNF Signaling, Cholinergic Activity, and Neuronal Density in the Hippocampus of an MSG-Induced Obesity Rat Model
- in-vivo, Obesity, NA - NA, AD, NA
*memory↑, *Mood↑, *CREB↑, *BDNF↑, *AChE↓, *cognitive↑, *neuroP↑,
4225- NarG,    Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury
- in-vivo, NA, NA
*motorD↑, *BDNF↑, *VEGF↑, *Bax:Bcl2↓, *Casp3↓, *Apoptosis↓, *eff↑,
1268- NCL,  carbop,    Inhibition of Wnt/β-catenin pathway by niclosamide: a therapeutic target for ovarian cancer
- in-vitro, Ovarian, NA
Wnt/(β-catenin)↓, ALDH1A1↓, LRP6↓,
1269- NCL,    Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway
- in-vitro, Pca, DU145
STAT3↓, TumCG↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cMyc↓, Bcl-xL↓,
1270- NCL,  Rad,    Niclosamide enhances the antitumor effects of radiation by inhibiting the hypoxia-inducible factor-1α/vascular endothelial growth factor signaling pathway in human lung cancer cells
- in-vivo, Lung, NA
Hif1a↓, VEGF↓,
1271- NCL,    Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics
- vitro+vivo, Ovarian, SKOV3
Wnt/(β-catenin)↓, mTOR↓, STAT3↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, MEK↓, ERK↓, mitResp↓, Glycolysis↓, ROS↑, JNK↑,
1267- NCL,    Niclosamide suppresses migration of hepatocellular carcinoma cells and downregulates matrix metalloproteinase-9 expression
- in-vitro, HCC, NA
TumCP↓, cycD1/CCND1↓, MMP9↓, TumCMig↓,
5253- NCL,    Niclosamide: Beyond an antihelminthic drug
- Review, Var, NA
TumCP↓, Apoptosis↑, EMT↓, β-catenin/ZEB1↓, TumCG↓, toxicity↓, Wnt↓, LRP6↓, eff↑, DR5↑, mTORC1↓, pH↓, CSCs↓, IL6↓, JAK1↓, STAT3↓, ChemoSen↑, TumCG↓, tumCV↓, NOTCH↓, NF-kB↓, EGFR↓, ROS↑, RadioS↑, cFos↓, cJun↓, E2Fs↓, cMyc↓, Half-Life↓, BioAv↝,
5254- NCL,    The magic bullet: Niclosamide
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, RAS↓, STAT3↓, NOTCH↓, E2Fs↓, mTOR↓, eff↑, PD-1↓, PD-L1↓, BioAv↝, toxicity↓, BioAv↑, ETC↑, NADH:NAD↓, TCA↑, Warburg↓, Diff↑, AMPK↑, P53↑, PP2A↑, HIF-1↓, KRAS↓, Myc↓, RadioS↑, ChemoSen↑, Dose↝, Dose↑,
5255- NCL,    Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, double-blind, placebo-controlled trial
- Trial, Nor, NA
BioAv↝, Dose↝, toxicity↓, BioAv↑, BioAv↝,
4973- Nimb,    Nimbolide Exhibits Potent Anticancer Activity Through ROS-Mediated ER Stress and DNA Damage in Human Non-small Cell Lung Cancer Cells
- in-vitro, NSCLC, A549
tumCV↓, ROS↑, ER Stress↑, DNAdam↑, Apoptosis↑, eff↓,
4970- Nimb,    Insights into Nimbolide molecular crosstalk and its anticancer properties
- Review, Var, NA
chemoPv↑, Apoptosis↑, TumCP↓, TumCD↑, TumMeta↓, angioG↓,

Showing Research Papers: 4101 to 4150 of 6107
Prev Page 83 of 123 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6107

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   GSH↓, 1,   lipid-P↓, 1,   OXPHOS↝, 1,   ROS↑, 9,   ROS↝, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

EGF↓, 1,   ETC↑, 1,   MEK↓, 1,   mitResp↓, 1,   MMP↓, 1,   MPT↑, 1,   mtDam↑, 1,   PGC-1α↑, 1,   e-Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMP↑, 1,   AMPK↑, 1,   cMyc↓, 2,   CREB↑, 1,   GLO-I↓, 1,   Glycolysis↓, 1,   LDL↓, 1,   NADH:NAD↓, 1,   TCA↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 4,   p‑Akt↓, 2,   Apoptosis↑, 7,   Bak↑, 1,   BAX↑, 2,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp↑, 1,   Casp3↑, 3,   Casp8↑, 1,   DR5↑, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↓, 1,   Myc↓, 1,   p27↑, 1,   p38↓, 1,   Pyro↑, 1,   survivin↓, 2,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

CaMKII ↑, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   other↓, 1,   tumCV↓, 4,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 2,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 2,   PARP1↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 3,   E2Fs↓, 2,   P21↓, 1,   P21↑, 2,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   cFos↓, 1,   CSCs↓, 1,   Diff↑, 1,   EMT↓, 3,   ERK↓, 2,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 1,   LRP6↓, 2,   mTOR↓, 4,   p‑mTOR↓, 1,   mTORC1↓, 1,   NOTCH↓, 4,   PI3K↓, 4,   RAS↓, 2,   STAT↓, 1,   STAT3↓, 5,   TumCG↓, 11,   TumCG↝, 3,   Wnt↓, 3,   Wnt/(β-catenin)↓, 2,  

Migration ⓘ

AntiAg↑, 1,   E-cadherin↓, 1,   KRAS↓, 1,   MMP2↓, 3,   MMP9↓, 3,   Na+↑, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   Treg lymp↓, 1,   TumCI↓, 3,   TumCMig↓, 2,   TumCP↓, 5,   TumCP↑, 1,   TumMeta↓, 6,   Twist↓, 1,   uPA↓, 1,   VCAM-1↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 4,   β-catenin/ZEB1↑, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   EGFR↓, 2,   HIF-1↓, 1,   Hif1a↓, 1,   TAMS↑, 1,   VEGF↓, 3,  

Barriers & Transport ⓘ

Na+↑, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CRP↓, 1,   IFN-γ↑, 1,   IL10↑, 1,   IL12↑, 1,   IL1β↓, 1,   IL2↑, 1,   IL6↓, 2,   Imm↑, 5,   INF-γ↓, 1,   Inflam↓, 1,   JAK↓, 1,   JAK1↓, 1,   NF-kB↓, 4,   NK cell↑, 1,   PD-1↓, 1,   PD-L1↓, 3,   TNF-α↓, 2,  

Cellular Microenvironment ⓘ

pH↓, 1,   pH↑, 5,   e-pH↑, 11,  

Protein Aggregation ⓘ

PP2A↑, 1,  

Hormonal & Nuclear Receptors ⓘ

CYP19↓, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 5,   BioAv↝, 5,   BioEnh↑, 2,   ChemoSen↓, 1,   ChemoSen↑, 7,   Dose↑, 1,   Dose↝, 6,   Dose∅, 1,   eff↓, 1,   eff↑, 20,   eff↝, 1,   Half-Life↓, 1,   Half-Life∅, 1,   P450↓, 1,   RadioS↑, 2,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

CRP↓, 1,   EGFR↓, 2,   GutMicro↑, 1,   GutMicro↝, 1,   IL6↓, 2,   KRAS↓, 1,   Myc↓, 1,   PD-L1↓, 3,  

Functional Outcomes ⓘ

AntiCan↓, 2,   AntiCan↑, 4,   AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 5,   Remission↑, 1,   toxicity↓, 4,   toxicity∅, 1,   TumVol↓, 3,   TumW↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 2,  
Total Targets: 181

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Bax:Bcl2↓, 1,   Casp3↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

neuroG↑, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   BDNF↑, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   BioEnh↑, 1,   eff↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   memory↑, 1,   Mood↑, 1,   motorD↑, 2,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 20

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page