Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
1170- MushCha,    Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism
- in-vitro, Oral, HSC4
tumCV↓, TumCP↓, TumCCA↑, STAT3↓, Glycolysis↓, MMP↓, TumAuto↑, p38↑, NF-kB↑,
2484- mushLions,    Neurotrophic and Neuroprotective Effects of Hericium erinaceus
- Review, Stroke, NA - Review, AD, NA - Review, Park, NA
*eff↑, *BBB↑, *Dose↝, *neuroP↑, *cognitive↑, *toxicity∅,
3815- mushLions,    Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*eff↑, *cognitive↑,
3810- mushLions,    Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer’s Disease
- Review, NA, NA
*neuroP↑, *p‑tau↓, *APP↓, *Aβ↓, *ROS↓, *Inflam↓, *NLRP3↓,
3814- mushLions,    Lion's Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model
- in-vitro, AD, NA
*neuroP↑, *cognitive↑, *cognitive∅, *BBB↑, *NGF↑, *BDNF↑, *NO↓, *memory↑, *Aβ↓,
3813- mushLions,    Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice
- in-vitro, AD, NA
*Aβ↓, *cognitive↑, *neuroP↑,
3812- mushLions,    Structural characterization of polysaccharide purified from Hericium erinaceus fermented mycelium and its pharmacological basis for application in Alzheimer's disease: Oxidative stress related calcium homeostasis
- in-vitro, AD, NA
*cognitive↑, *Aβ↓, *p‑tau↓, *ROS↓, *NRF2↓, *Ca+2↝,
3811- mushLions,    Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment
- in-vitro, NA, NA
*memory↑, *BBB↑, *GSH↑, *AChE↓, *MDA↓,
3809- mushLions,    The Monkey Head Mushroom and Memory Enhancement in Alzheimer's Disease
- Review, NA, NA
*cognitive↑, *Apoptosis↓, *Aβ↓, *AChE↓, *BACE↓,
3808- mushLions,    Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging
- in-vitro, NA, NA
*Inflam↓, *ROS↓, *neuroP↑,
3807- mushLions,    Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The “Longevity Vitamin” Improves Locomotor Performances during Aging
*AntiAge↑, *other↑, *NOS2↓, *COX2↓, *P53↑, *neuroP↑,
3806- mushLions,    Dietary Supplementation of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), and Spatial Memory in Wild-Type Mice
- in-vitro, NA, NA
*motorD↑, *memory↑,
1573- MushReishi,    Ganoderma lucidum (Reishi mushroom) for cancer treatment
- Review, NA, NA
ChemoSen↑, CR3↝, eff↑, NK cell↑, T-Cell↑, QoL↑,
930- MushShi,    Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation
- in-vitro, Ovarian, NA
p‑STAT3↓, PTPN6↑, cycD1/CCND1↓, Bcl-2↓, Mcl-1↓, survivin↓, VEGF↓,
2- MushShi,    The Effects of Active Hexose Correlated Compound (AHCC) on Levels of CD4+ and CD8+ in Patients with Epithelial Ovarian Cancer or Peritoneal Cancer Receiving Platinum Based Chemotherapy
- Human, Ovarian, NA
CD8+↑, Pain↑,
3- MushShi,    AHCC Activation and Selection of Human Lymphocytes via Genotypic and Phenotypic Changes to an Adherent Cell Type: A Possible Novel Mechanism of T Cell Activation
*LAT↑, *FLRT2↑, *GIT1↑, *T-Cell↑,
1044- Myr,    Myricetin inhibits interferon-γ-induced PD-L1 and IDO1 expression in lung cancer cells
- in-vitro, Lung, NA
PD-L1↓, IDO1↓,
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, NA, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,
1128- Myr,    Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer
- vitro+vivo, Ovarian, NA
MAPK↓, ERK↓, PI3K↓, Akt↓, p‑PARP↑, cl‑Casp3↑, Bax:Bcl2↑, TumCMig↓, SMAD3↓,
1273- Myr,    Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4
- vitro+vivo, GC, NA
Ferroptosis↑, MDA↑, Iron↑, GSH↓, NOX4↑, NRF2↓, GPx4↓,
1998- Myr,  CUR,    Thioredoxin-dependent system. Application of inhibitors
- Review, Var, NA
TrxR↓, ROS↑,
1997- Myr,  QC,    Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity
- in-vitro, Lung, A549
TrxR↓, eff↑, TumCCA↑, eff↓, ROS↑,
116- Myrrh,    The Role of Myrrh Metabolites in Cancer, Inflammation, and Wound Healing: Prospects for a Multi-Targeted Drug Therapy
- in-vitro, AML, HL-60 - in-vitro, AML, K562 - in-vitro, BC, KAIMRC1
ROS↑, M1↑, M2 MC↑, Apoptosis?, BBB↝,
4167- NAC,    N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action
- Review, NA, NA
*GSH↑, *antiOx↑, *ROS↓,
4160- NAD,    The biochemical pathways of central nervous system neural degeneration in niacin deficiency
- Review, NA, NA
*BDNF↑, *TrkB↑,
4035- NAD,  VitB3,    NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING
- in-vitro, AD, NA
*Inflam↓, *DNAdam↓, *NLRP3↓, *cGAS–STING↓,
4036- NAD,  VitB3,    NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
- in-vivo, AD, NA
*Inflam↓, *p‑tau↓, *DNAdam↓, *memory↑, *motorD↑, *cognitive↑, *BBB↑, IL1β↓, *TNF-α↓, *MCP1↓, *RANTES↓, *ROS↓, *SIRT3↑, *SIRT6↑,
5786- NAD,    Therapeutic potential of NAD-boosting molecules: the in vivo evidence
- Review, Nor, NA
*Dose↝, *eff↑, *cognitive↑, *neuroP↑,
5787- NAD,    Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
- in-vitro, Nor, NA
*CRM↑, *OS↑,
2938- NAD,    NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling
- in-vivo, BC, NA
TumMeta↓, SIRT1↑,
2931- NAD,    NAD+ Repletion Rescues Female Fertility during Reproductive Aging
- in-vivo, Nor, NA
*eff↑, *SIRT2↑, *other↑, *Dose↝,
2932- NAD,    Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment
- in-vitro, Nor, NA
*SIRT1↑, *HO-1↑, *neuroP↑, *Apoptosis↓, *Inflam↓, *ROS↓, *antiOx↑, *toxicity↓,
2933- NAD,    Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns
- Review, Nor, NA - NA, AD, NA - NA, Diabetic, NA - NA, Stroke, NA - NA, LiverDam, NA - NA, Park, NA
*mtDam↓, *BioAv↝, *BioAv↑, *OS↑, *eff↑, *eff↑, *cognitive↑, *DNAdam↓, *SIRT1↑, *cardioP↑, *ROS↓, *Dose↝, *BioAv↑, *hepatoP↑, *eff↑, *BG↓, *creat↓,
2934- NAD,    The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial
- Trial, Nor, NA
*Dose↑, *Strength↑,
2935- NAD,    Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner
- in-vitro, Nor, NA
*GutMicro↑, *OS↑,
2936- NAD,    The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
*ROS↓, *DNAdam↓, *neuroP↑, *Inflam↓, *BioAv↑, *SIRT1↑, BioAv↝,
2939- NAD,  Rad,    NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7
- in-vitro, Nor, NA
*SIRT6↑, *DNAdam↓, *radioP↑, *ROS↓,
2937- NAD,    High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway
- in-vitro, Lung, A549
SIRT1↑, Dose↝, TumCP⇅, Ferroptosis↑, lipid-P↑, AMPK↑, ACC↑,
5611- NaHCO3,    NaHCO3 enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells
- vitro+vivo, HCC, HepG2
tumCV↓, TumCG↓, pH↑, eff↑, Imm↑,
5598- NaHCO3,    Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases
- in-vivo, BC, MDA-MB-231
e-pH↑, TumMeta↓, TumCG⇅, Dose↑,
5620- NaHCO3,    Tumor acidity: From hallmark of cancer to target of treatment
- Review, Var, NA
e-pH↑, TumCG↓, eff↑, OS↑, eff↑, BioAv↑,
5619- NaHCO3,    Safety and efficacy of sodium bicarbonate for treating metabolic acidosis in chronic kidney disease: A systematic review and meta-analysis
- Review, CKD, NA
*eff↑, toxicity↓, GFR↑, toxicity↝,
5618- NaHCO3,    Association between sodium bicarbonate consumption and human health: A systematic review
- Review, Nor, NA
*toxicity↓,
5617- NaHCO3,    Microenvironmental alkalization promotes the therapeutic effects of MSLN-CAR-T cells
- vitro+vivo, NA, NA
Imm↑, eff↑, pH↑,
5616- NaHCO3,  DCA,    Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer
- vitro+vivo, BC, MDA-MB-231
OS↑, e-pH↑, TumMeta↓, eff↝, TumCG↝,
5615- NaHCO3,  immuno,    pH-Responsive Nanoparticles for Cancer Immunotherapy: A Brief Review
- Review, Var, NA
eff↑, eff↑, pH↑,
5614- NaHCO3,    Targeting the Acidic Tumor Microenvironment: Unexpected Pro-Neoplastic Effects of Oral NaHCO3 Therapy in Murine Breast Tissue
- in-vivo, BC, NA
e-pH↑, TumCG↝, TumCP↑,
5613- NaHCO3,    The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Acid-Mediated Invasion
- Study, Var, NA
pH↑, TumCG↓, TumCI↓, selectivity↑,
5612- NaHCO3,  immuno,    Neutralization of tumor acidity improves anti-tumor responses to immunotherapies
- vitro+vivo, Var, B16-F10
Imm↑, eff↑, e-pH↑, TumCG↓, TumMeta↓, eff↑,
5599- NaHCO3,    Acidity generated by the tumor microenvironment drives local invasion
- in-vivo, BC, MDA-MB-231 - in-vitro, CRC, HCT116
e-pH↑, TumCG↓, TumCI↓, Dose↝,

Showing Research Papers: 4101 to 4150 of 6149
Prev Page 83 of 123 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6149

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 2,   GPx4↓, 1,   GSH↓, 1,   Iron↑, 1,   lipid-P↑, 1,   MDA↑, 1,   NOX4↑, 1,   NRF2↓, 1,   ROS↑, 3,   SIRT3↑, 1,   TrxR↓, 2,  

Mitochondria & Bioenergetics ⓘ

MEK↓, 1,   MKK4↓, 1,   MMP↓, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↑, 1,   AMPK↑, 1,   Glycolysis↓, 1,   IDO1↓, 1,   SIRT1↑, 2,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis?, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 1,   BMP2↓, 1,   cl‑Casp3↑, 1,   Ferroptosis↑, 2,   MAPK↓, 1,   Mcl-1↓, 1,   p38↓, 1,   p38↑, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 2,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 2,  

DNA Damage & Repair ⓘ

p‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   PI3K↓, 1,   PTPN6↑, 1,   STAT3↓, 1,   p‑STAT3↓, 1,   TumCG↓, 5,   TumCG⇅, 1,   TumCG↝, 2,  

Migration ⓘ

F-actin↓, 1,   MMP2↓, 1,   MMP9↓, 1,   SMAD3↓, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 1,   TumCP↑, 1,   TumCP⇅, 1,   TumMeta↓, 4,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   VEGF↓, 2,  

Barriers & Transport ⓘ

BBB↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CR3↝, 1,   IL1β↓, 1,   Imm↑, 3,   M1↑, 1,   M2 MC↑, 1,   NF-kB↑, 1,   NK cell↑, 1,   PD-L1↓, 1,   T-Cell↑, 1,  

Cellular Microenvironment ⓘ

pH↑, 4,   e-pH↑, 6,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 1,   Dose↑, 1,   Dose↝, 2,   eff↓, 1,   eff↑, 10,   eff↝, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

GFR↑, 1,   OS↑, 2,   Pain↑, 1,   QoL↑, 1,   toxicity↓, 1,   toxicity↝, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 91

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   GSH↑, 2,   HO-1↑, 1,   MDA↓, 1,   NRF2↓, 1,   ROS↓, 9,   SIRT3↑, 1,  

Mitochondria & Bioenergetics ⓘ

mtDam↓, 1,  

Core Metabolism/Glycolysis ⓘ

CRM↑, 1,   LAT↑, 1,   SIRT1↑, 3,   SIRT2↑, 1,  

Cell Death ⓘ

Akt↑, 1,   Apoptosis↓, 2,  

Transcription & Epigenetics ⓘ

other↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↓, 5,   P53↑, 1,   SIRT6↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↑, 1,  

Migration ⓘ

APP↓, 1,   Ca+2↝, 1,   FLRT2↑, 1,   GIT1↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

BBB↑, 4,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 6,   MCP1↓, 1,   RANTES↓, 1,   T-Cell↑, 1,   TNF-α↓, 1,  

Cellular Microenvironment ⓘ

cGAS–STING↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   BDNF↑, 2,   NGF↑, 1,   p‑tau↓, 3,   TrkB↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 5,   BACE↓, 1,   NLRP3↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 3,   BioAv↝, 1,   Dose↑, 1,   Dose↝, 4,   eff↑, 8,  

Clinical Biomarkers ⓘ

BG↓, 1,   creat↓, 1,   GutMicro↑, 1,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   cardioP↑, 1,   cognitive↑, 9,   cognitive∅, 1,   hepatoP↑, 1,   memory↑, 4,   motorD↑, 2,   neuroP↑, 9,   OS↑, 3,   radioP↑, 1,   Strength↑, 1,   toxicity↓, 2,   toxicity∅, 1,  
Total Targets: 62

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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