Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
2945- PL,    Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells
- in-vitro, CRC, HCT116
ROS↑, SMAD4↑, ChemoSen↑, P53↑, P21↑, BAX↑, Bcl-2↓, survivin↓, TumCMig↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp↓, MDR1↓, MRP1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2947- PL,    Piperlongumine: the amazing amide alkaloid from Piper in the treatment of breast cancer
- Review, Var, NA
TumCP↓, Apoptosis↑, TumCCA↑, ROS↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
2949- PL,    Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation
- in-vitro, GBM, LN229 - in-vitro, GBM, U87MG
selectivity↑, ROS↑, JNK↑, p38↑, GSH↓, eff↓,
2950- PL,    Overview of piperlongumine analogues and their therapeutic potential
- Review, Var, NA
AntiAg↑, neuroP↑, Inflam↓, NO↓, PGE2↓, MMP3↓, MMP13↓, TumCMig↓, TumCI↓, p38↑, JNK↑, NF-kB↑, ROS↑, FOXM1↓, TrxR1↓, GSH↓, Trx↓, cMyc↓, Casp3↑, Bcl-2↓, Mcl-1↓, STAT3↓, AR↓, DNAdam↑,
2951- PL,  AF,    Synergistic Dual Targeting of Thioredoxin and Glutathione Systems Irrespective of p53 in Glioblastoma Stem Cells
- in-vitro, GBM, U87MG
GSH↓, eff↑, GSTP1/GSTπ↓,
2953- PL,    Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished TH17 but Enhanced Treg Differentiation
- in-vitro, Nor, NA
*ROS↑, *GSTA1↓, eff↝, *toxicity↓, ROS↑, *Hif1a↓,
2952- PL,    Piperlongumine suppresses bladder cancer invasion via inhibiting epithelial mesenchymal transition and F-actin reorganization
- in-vitro, Bladder, T24/HTB-9 - in-vivo, Bladder, NA
TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, ROS↑, Slug↓, β-catenin/ZEB1↓, Zeb1↓, N-cadherin↓, F-actin↓, GSH↓, EMT↓, CLDN1↓, ZO-1↓,
2965- PL,  docx,    Piperlongumine for enhancing oral bioavailability and cytotoxicity of docetaxel in triple negative breast cancer
- Analysis, Var, NA
BioEnh↑, eff↑,
2963- PL,    Piperlongumine activates Sirtuin1 and improves cognitive function in a murine model of Alzheimer’s disease
- in-vitro, AD, HEK293
*SIRT1↑, *cognitive↑, *Aβ↓, *Inflam↓, *neuroP↑, memory↑, Dose↓, NAD↑,
2962- PL,    Synthesis of Piperlongumine Analogues and Discovery of Nuclear Factor Erythroid 2‑Related Factor 2 (Nrf2) Activators as Potential Neuroprotective Agents
- in-vitro, Nor, PC12
*GSH↑, *NQO1↑, *Trx↑, *TrxR↑, *NRF2↑, *NRF2⇅, *eff↑, *BioAv↑, *ROS↓,
2961- PL,    Piperlongumine inhibits esophageal squamous cell carcinoma in vitro and in vivo by triggering NRF2/ROS/TXNIP/NLRP3-dependent pyroptosis
- in-vitro, ESCC, KYSE-30
Pyro↑, TumCP↓, TumCMig↓, TumCI↓, ASC↑, cl‑Casp1↑, NLRP3↑, GSDMD↑, ROS↑, NRF2↓, TXNIP↑,
2960- PL,    Synthesis of Piperlongumine Analogues and Discovery of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators as Potential Neuroprotective Agents
- Analysis, Nor, NA
NRF2↑, neuroP↑,
2959- PL,    Piperlongumine mitigates LPS-induced inflammation and lung injury via targeting MD2/TLR4
- in-vivo, Nor, NA
*Inflam↓,
2958- PL,    Natural product piperlongumine inhibits proliferation of oral squamous carcinoma cells by inducing ferroptosis and inhibiting intracellular antioxidant capacity
- in-vitro, Oral, HSC3
TumCP↓, lipid-P↑, ROS↑, DNMT1↑, FTH1↓, GPx4↓, eff↓, GSH↓, Ferroptosis↑, MDA↓,
2957- PL,    Piperlongumine Induces Cell Cycle Arrest via Reactive Oxygen Species Accumulation and IKKβ Suppression in Human Breast Cancer Cells
- in-vitro, BC, MCF-7
TumCP↓, TumCMig↓, TumCCA↑, ROS↑, H2O2↑, GSH↓, IKKα↓, NF-kB↓, P21↑, eff↓,
2955- PL,    Heme Oxygenase-1 Determines the Differential Response of Breast Cancer and Normal Cells to Piperlongumine
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
ROS?, *ROS∅, other⇅, HO-1↑, *HO-1↑, NRF2↑, Keap1↓, cl‑PARP↑, selectivity↑, GSH↓, GSSG↑,
2954- PL,    The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy
- Review, Var, NA
NRF2↑, ROS↑, ER Stress↑, MAPK↑, CHOP↑, selectivity↑, Keap1↝, HO-1↑, Ferroptosis↑,
2651- PLB,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
ROS↑, TrxR↓, GSR↓, ER Stress↓, TumCCA↑, MMP↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MKP1↓, MKP2↓, ChemoSen↑,
2004- PLB,    Plumbagin Inhibits Proliferative and Inflammatory Responses of T Cells Independent of ROS Generation But by Modulating Intracellular Thiols
- in-vivo, Var, NA
TumCP↓, TumCG↓, NF-kB↓, ROS↑, GSH↓, eff↓, i-Thiols↓, GSH/GSSG↓, *GSH↓, *ROS↑,
2006- PLB,    Plumbagin induces apoptosis in human osteosarcoma through ROS generation, endoplasmic reticulum stress and mitochondrial apoptosis pathway
- in-vitro, OS, MG63 - in-vitro, Nor, hFOB1.19
tumCV↓, selectivity↑, mtDam↑, Ca+2↓, ER Stress↑, ROS↑, Casp3↑, Casp9↑, Apoptosis↑, eff↓,
2005- PLB,    Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)
- in-vivo, Nor, EL4 - in-vitro, AML, Jurkat
JNK↑, Cyt‑c↑, FasL↑, BAX↑, ROS↑, *ROS↑, MKP1↓, MKP2↓, selectivity∅, tumCV↑, Cyt‑c↑, Casp3↑, GSH/GSSG↓, ROS↑, mt-ROS↑, *ROS↑, eff↓,
5160- PLB,  VitK3,    Plumbagin, Vitamin K3 Analogue, Suppresses STAT3 Activation Pathway through Induction of Protein Tyrosine Phosphatase, SHP-1: Potential Role in Chemosensitization
- in-vitro, Melanoma, U266
STAT3↓, cSrc↓, JAK1↓, JAK2↓, SHP1↑, cycD1/CCND1↓, Bcl-xL↓, VEGF↓, Casp3↑, cl‑PARP↑, TumCCA↑, ChemoSen↑,
5164- PLB,    Plumbagin inhibits tumour angiogenesis and tumour growth through the Ras signalling pathway following activation of the VEGF receptor-2
- vitro+vivo, CRC, NA - in-vitro, Pca, NA
TumCP↓, TumCMig↓, angioG↓, VEGFR2↓,
5163- PLB,    Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells
- in-vitro, SCC, SCC25
TumCP↓, NRF2↓, TumCCA↑, EMT↓, CSCs↓, eff↓, ROS↑, CycB/CCNB1↓, CDK1↓, CDK2↓, CDC25↓, Vim↓, OCT4↓, SOX2↓, Nanog↓, BMI1↓, NQO1↓, GSTA1↓, HSP90↓, toxicity↓,
5162- PLB,    Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells
- vitro+vivo, Melanoma, A172
TumCG↓, TumCCA↑, Apoptosis↑, P21↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDC2↓, CDC25↑, Bax:Bcl2↑, Casp9↑, ROS↑, JNK↑, ERK↑, eff↓,
5161- PLB,    Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
- in-vitro, SCC, SCC25
TumCCA↑, Apoptosis↑, TumAuto↑, Bcl-2↓, Bcl-xL↓, BAX↑, PI3K↓, Akt↓, mTOR↓, GSK‐3β↓, MAPK↓, ROS↑, eff↓, CDC2↓, CycB/CCNB1↓, P21↑, p27↑, P53↑, Casp9↑, Casp3↑,
5159- PLB,    Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression
- in-vitro, AML, K562
tumCV↓, Apoptosis↑, ROS↑, eff↓, DR4↑, DR5↑, TRAIL↑,
5158- PLB,    Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells
- in-vitro, Cerv, ME-180
TumCG↓, ROS↑, Apoptosis↑, MMP↓, DNAdam↑, Cyt‑c↑, AIF↑, Casp3↑, Casp9↑, eff↓,
4866- ProBio,    Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis
- in-vivo, AD, NA
*memory↑, *other↝, *GutMicro↝, *GutMicro↝, *GutMicro↝,
1046- ProBio,  immuno,    Combination Therapy of Bifidobacterium longum RAPO With Anti-PD-1 Treatment Enhances Anti-tumor Immune Response in Association With Gut Microbiota Modulation
- in-vivo, NA, NA
TumVol↓, GutMicro↑,
5630- ProBio,  Bif,    EFFICACY OF PROBIOTICS IN PREVENTING CHEMOTHERAPY-INDUCED DIARRHEA IN GASTROINTESTINAL CANCER PATIENTS
- Trial, GC, NA
Dose↝, Diar⇅,
5624- ProBio,  Bif,    A randomized double-blind placebo-controlled trial of probiotics in post-surgical colorectal cancer
- Trial, Testi, NA
Dose↝, TNF-α↓, IL6↓, IL10↓, IL12↓, IL22↓, toxicity↓,
4170- ProBio,  PB,    Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine
- in-vivo, NA, NA
*BDNF↑, *GutMicro↑,
3908- PS,    The effect of phosphatidylserine-containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study
- Human, AD, NA
*cognitive↑, *memory↑,
3917- PS,    Phosphatidylserine, inflammation, and central nervous system diseases
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *neuroP↑, *cognitive↑, *Choline↑, *IL1β↓, *IL6↓, *TNF-α↓, *Ach↑, *eff↑, *eff↑, *BioEnh↑, other↑,
3916- PS,    The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study
- Human, AD, NA
*memory↑, *cognitive↑, *BP↓, *Dose↝, *eff↑,
3915- PS,    Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer's disease and dementia
- Trial, AD, NA
*memory↑, *cognitive↑, *Half-Life↝, *Mood↑,
3914- PS,    Soybean-Derived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints
- Trial, AD, NA
*memory↑, *cognitive↑, *lipid-P↓, *antiOx↑, *Inflam↓,
3907- PS,    Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer's disease. A neuropsychological, EEG, and PET investigation
- Study, AD, NA
*cognitive↝,
3913- PS,    An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline
- Human, AD, NA
*cognitive↑,
3912- PS,    Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration
- Study, AD, NA
cognitive↑,
3911- PS,  VitE,    Cognitive effects of a dietary supplement made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in subjects with mild cognitive impairment: a noncomparative, exploratory clinical study
- Human, AD, NA
*cognitive↑, *other↑,
3910- PS,    Neuroprotective Effect of Bean Phosphatidylserine on TMT-Induced Memory Deficits in a Rat Model
- in-vivo, AD, NA
*memory↑, *neuroP↑, *GlucoseCon↑, *ChAT↑,
3909- PS,    Double-blind study with phosphatidylserine (PS) in parkinsonian patients with senile dementia of Alzheimer's type (SDAT)
- Study, AD, NA
*cognitive↑,
3906- PS,    Effects of phosphatidylserine in Alzheimer's disease
- Study, AD, NA
*cognitive↑,
4965- PSO,  Cisplatin,    The synergistic antitumor effects of psoralidin and cisplatin in gastric cancer by inducing ACSL4-mediated ferroptosis
- vitro+vivo, GC, HGC27 - vitro+vivo, GC, MKN45
TumCP↓, TumCMig↓, TumCI↓, TumCG↓, *toxicity↓, eff↑, Ferroptosis↑, ACSL4↑, GPx4↓, ChemoSen↑, chemoP↑, AntiTum↑, Sepsis↓,
4969- PSO,    The Coumarin Psoralidin Enhances Anticancer Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
- in-vitro, Cerv, HeLa
AntiCan↑, chemoPv↑, TRAIL↑, selectivity↑, toxicity↓, MMP↓, Apoptosis↑,
4968- PSO,    Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer
- in-vitro, Cerv, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiDiabetic↑, *Bacteria↓, AntiTum↑, CSCs↓, ROS↑, TumAuto↑, Apoptosis↑, ChemoSen↑, RadioS↑, BioAv↓, *cardioP↑, *ROS↓, *LDH↓, TumCP↓, TRAIL⇅, TumCMig↓, EMT↓, NF-kB↓, P53↑, Casp3↑, NOTCH↓, CSCs↓, angioG↓, VEGF↓, Ki-67↓, CD31↓, TRAILR↑, MMP↓, BioAv↓, BioAv↑,

Showing Research Papers: 4251 to 4300 of 5901
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5901

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 3,   GPx4↓, 2,   GSH↓, 10,   GSH/GSSG↓, 2,   GSR↓, 1,   GSSG↑, 1,   GSTA1↓, 1,   GSTP1/GSTπ↓, 1,   H2O2↑, 1,   HO-1↑, 4,   Keap1↓, 1,   Keap1↝, 1,   lipid-P↑, 1,   MDA↓, 1,   MDA↑, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 2,   NRF2↑, 5,   Prx4↑, 1,   ROS?, 1,   ROS↑, 22,   mt-ROS↑, 1,   SOD↑, 1,   SOD1↑, 1,   SOD2↑, 1,   i-Thiols↓, 1,   Trx↓, 1,   TrxR↓, 3,   TrxR1↓, 1,  

Metal & Cofactor Biology ⓘ

FTH1↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   CDC2↓, 2,   CDC25↓, 1,   CDC25↑, 1,   MMP↓, 4,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACSL4↑, 1,   cMyc↓, 3,   Glycolysis↓, 2,   HK2↓, 2,   NAD↑, 1,  

Cell Death ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Apoptosis↑, 8,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 4,   Bcl-xL↓, 2,   BIM↑, 1,   cl‑Casp1↑, 1,   Casp3↑, 9,   Casp7↑, 2,   Casp8↑, 1,   Casp9↑, 5,   Cyt‑c↑, 4,   DR4↑, 1,   DR5↑, 1,   FasL↑, 1,   Ferroptosis↑, 3,   GSDMD↑, 1,   JNK↑, 4,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↓, 1,   MDM2↓, 1,   MKP1↓, 2,   MKP2↓, 2,   p27↑, 1,   p38↑, 2,   Pyro↑, 1,   survivin↓, 3,   TRAIL↑, 2,   TRAIL⇅, 1,   TRAILR↑, 1,  

Kinase & Signal Transduction ⓘ

cSrc↓, 1,   p‑HER2/EBBR2↓, 1,   Sp1/3/4↓, 3,  

Transcription & Epigenetics ⓘ

other↑, 1,   other⇅, 1,   tumCV↓, 3,   tumCV↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 3,   HSP90↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 3,   DNMT1↑, 1,   P53↑, 4,   cl‑PARP↑, 3,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 2,   CDK2↓, 2,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 4,   cycD1/CCND1↓, 3,   P21↑, 6,   RB1↓, 1,   p‑RB1↓, 1,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State ⓘ

BMI1↓, 1,   cFos↓, 1,   cMET↓, 1,   CSCs↓, 3,   EMT↓, 4,   ERK↓, 1,   ERK↑, 1,   FOXM1↓, 1,   p‑FOXO3↓, 1,   GSK‐3β↓, 2,   mTOR↓, 4,   Nanog↓, 2,   NOTCH↓, 1,   OCT4↓, 2,   PI3K↓, 2,   PTEN↑, 1,   RAS↓, 1,   SHP1↑, 1,   SOX2↓, 2,   STAT1↓, 1,   STAT3↓, 4,   STAT6↓, 1,   TOP2↓, 1,   TumCG↓, 5,  

Migration ⓘ

AntiAg↑, 1,   AP-1↓, 1,   Ca+2↓, 1,   CD31↓, 1,   CLDN1↓, 1,   E-cadherin↑, 1,   F-actin↓, 1,   Ki-67↓, 2,   MMP13↓, 1,   MMP3↓, 1,   MMP9↓, 2,   N-cadherin↓, 2,   Slug↓, 2,   SMAD4↑, 1,   Snail↓, 1,   SOX4↑, 1,   TumCI↓, 6,   TumCMig↓, 8,   TumCP↓, 11,   TumMeta↓, 2,   Twist↓, 2,   TXNIP↑, 1,   Vim↓, 2,   Zeb1↓, 1,   ZO-1↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   ATF4↑, 1,   ATF4↝, 1,   EGFR↓, 1,   NO↓, 1,   VEGF↓, 3,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↑, 1,   COX2↓, 1,   CXCR4↓, 1,   ICAM-1↓, 1,   IKKα↓, 2,   IL10↓, 1,   IL12↓, 1,   IL22↓, 1,   IL6↓, 3,   IL8↓, 1,   Inflam↓, 2,   JAK1↓, 2,   JAK2↓, 2,   NF-kB↓, 6,   NF-kB↑, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Protein Aggregation ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 2,   BioEnh↑, 2,   ChemoSen↑, 7,   Dose↓, 1,   Dose↝, 2,   eff↓, 11,   eff↑, 5,   eff↝, 1,   Half-Life↝, 1,   MDR1↓, 1,   MRP1↓, 1,   RadioS↑, 3,   selectivity↑, 7,   selectivity∅, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   EGFR↓, 1,   FOXM1↓, 1,   GutMicro↑, 1,   p‑HER2/EBBR2↓, 1,   IL6↓, 3,   Ki-67↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 2,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   memory↑, 1,   neuroP↑, 2,   toxicity↓, 4,   TumVol↓, 1,   TumW↓, 1,  

Infection & Microbiome ⓘ

Diar⇅, 1,   Sepsis↓, 1,  
Total Targets: 217

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   GSH↓, 1,   GSH↑, 2,   GSTA1↓, 1,   HO-1↑, 1,   lipid-P↓, 2,   NQO1↑, 1,   NRF2↑, 1,   NRF2⇅, 1,   ROS↓, 2,   ROS↑, 4,   ROS∅, 1,   Trx↑, 1,   TrxR↑, 1,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↑, 1,   LDH↓, 1,   SIRT1↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↑, 1,   other↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

Choline↑, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   IL6↓, 1,   Inflam↓, 5,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,   ChAT↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioEnh↑, 1,   Dose↝, 1,   eff↑, 4,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,   GutMicro↑, 1,   GutMicro↝, 3,   IL6↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cardioP↑, 1,   cognitive↑, 10,   cognitive↝, 1,   hepatoP↑, 1,   memory↑, 6,   Mood↑, 1,   neuroP↑, 4,   toxicity↓, 2,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 49

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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