Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
5217- PG,    Role of redox signaling regulation in propyl gallate-induced apoptosis of human leukemia cells
- in-vitro, AML, THP1 - in-vitro, AML, Jurkat - in-vitro, AML, HL-60
tumCV↓, Casp3↑, Casp8↑, Casp9↑, P53↑, BAX↑, Fas↑, FasL↑, MAPK↑, NRF2↓, GSH↓,
5218- PG,    Propyl gallate inhibits hepatocellular carcinoma cell growth through the induction of ROS and the activation of autophagy
- in-vitro, HCC, Hep3B
TumCP↓, Apoptosis↑, ROS↑, TumAuto↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, BAD↑, Bcl-2↓, toxicity↓, hepatoP↑, GSH↓,
5219- PG,    Propyl gallate inhibits the growth of HeLa cells via caspase-dependent apoptosis as well as a G1 phase arrest of the cell cycle
- in-vitro, Cerv, HeLa
TumCG↓, TumCCA↑, p27↑, Apoptosis↑, MMP↓, Casp3↑, Casp8↑, cl‑PARP↑,
1766- PG,    Propyl gallate induces human pulmonary fibroblast cell death through the regulation of Bax and caspase-3
- in-vitro, Nor, NA
TumCCA↑, MMP↓,
1767- PG,    Propyl gallate induces cell death in human pulmonary fibroblast through increasing reactive oxygen species levels and depleting glutathione
- in-vitro, Nor, NA
*ROS↑, *GSH↓, *SOD↓, *Catalase↓, eff↓,
1768- PG,    Propyl gallate reduces the growth of lung cancer cells through caspase‑dependent apoptosis and G1 phase arrest of the cell cycle
- in-vitro, Lung, Calu-6 - in-vitro, Lung, A549
TumCG↓, TumCCA↑, Dose∅, Bcl-2↓, cl‑PARP↑, MMP↓, Casp3↑, Casp8↑,
1769- PG,    The Anti-Apoptotic Effects of Caspase Inhibitors in Propyl Gallate-Treated Lung Cancer Cells Are Related to Changes in Reactive Oxygen Species and Glutathione Levels
- in-vitro, Lung, Calu-6 - in-vitro, Lung, A549
TumCP↓, eff↑, ROS↑, GSH↓,
1770- PG,    Propyl gallate sensitizes human lung cancer cells to cisplatin-induced apoptosis by targeting heme oxygenase-1 for TRC8-mediated degradation
- in-vitro, Lung, NA
antiOx↑, Inflam↓, HO-1↓, eff↑, ChemoSen↑,
1772- PG,    Propyl gallate decreases the proliferation of Calu-6 and A549 lung cancer cells via affecting reactive oxygen species and glutathione levels
- in-vitro, Lung, Calu-6 - in-vitro, Lung, A549
ROS⇅, TumCP↓, GSH↓,
1774- PG,    Geno- and cytotoxicity of propyl gallate food additive
- in-vitro, Lung, A549
TumCG↓, Dose∅, DNAdam↑,
1771- PG,    Pharmacokinetic and toxicological overview of propyl gallate food additive
- Human, Nor, NA
*toxicity∅,
1764- PG,  Cu,    DNA strand break induction and enhanced cytotoxicity of propyl gallate in the presence of copper(II)
- in-vitro, Nor, GM05757
*DNAdam↑, *ROS↑, *Dose∅, *DNAdam∅,
1763- PG,    Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment
- Review, NA, NA
*antiOx↑, *ROS↓, *ROS↑,
1765- PG,    Enhanced cell death effects of MAP kinase inhibitors in propyl gallate-treated lung cancer cells are related to increased ROS levels and GSH depletion
- in-vitro, Lung, A549 - in-vitro, Lung, Calu-6
TumCD↑, MMP↓, ROS↑, GSH↓, Dose∅, eff↑,
1164- PI,    Inhibition of T cell activation by the phytochemical piperine
- in-vitro, Nor, NA
*other↓, *CD25+↓, *IFN-γ↓, *IL2↓, *IL4↓, *IL17↓, *CD69↓, *CTLA-4↓, *p‑ERK↓, *IKKα↓,
1162- PI,    Piperine Inhibits the Activities of Platelet Cytosolic Phospholipase A2 and Thromboxane A2 Synthase without Affecting Cyclooxygenase-1 Activity: Different Mechanisms of Action Are Involved in the Inhibition of Platelet Aggregation and Macrophage Inflammatory Response
- in-vitro, NA, NA
*cPLA2↓, TXA2↓, COX2↓, PGE2↓, PGD2↓,
1165- PI,    Piperine inhibits IL-1β-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells
- in-vitro, GC, TMK-1
p38↓, IL6↓, STAT3↓,
1163- PI,    The Effect of Piperine on MMP-9, VEGF, and E-cadherin Expression in Breast Cancer MCF-7 Cell Line
- in-vitro, BC, MC38
tumCV↓, VEGF↓, MMP9↓, E-cadherin↓,
1258- PI,    Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer
- in-vivo, CRC, NA
COX2↓, IL6↓, EMT↓, β-catenin/ZEB1↓, Snail↓, Symptoms∅,
1257- PI,    Piperlongumine attenuates bile duct ligation-induced liver fibrosis in mice via inhibition of TGF-β1/Smad and EMT pathways
- ex-vivo, LiverDam, NA
*Fibronectin↓, *α-SMA↓, *COL1↓, *COL3A1↓, *TGF-β↓, *EMT↓, *MMP2↓, *α-SMA↓, *Smad7↑, *E-cadherin↑, *Vim↓, *hepatoP↑, *antiOx↑, *GSH↑, *ROS↓,
1256- PI,    Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
- in-vitro, adrenal, PHEO - in-vivo, NA, NA
Apoptosis↑, ROS↑, TumCMig↓, TumCI↓, EMT↓, angioG↓, Necroptosis↑, MAPK↑, ERK↑,
1255- PI,  ALA,    Antileukemic effects of piperlongumine and alpha lipoic acid combination on Jurkat, MEC1 and NB4 cells in vitro
- in-vitro, CLL, NA
COX2↓, Casp3↑,
1254- PI,  VitC,    Piperlongumine combined with vitamin C as a new adjuvant therapy against gastric cancer regulates the ROS–STAT3 pathway
- in-vivo, GC, NA
STAT3⇅, eff↑, ROS↑, Apoptosis↑,
5210- PI,    Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells
- in-vitro, Melanoma, B16-BL6
IL1β↓, TNF-α↓, MMPs↓, p65↓, p50↓, NF-kB↓, ATF2↓, cFos↓, CREB↓,
5209- PI,    Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP-9 signaling pathway in DU145 cells
- in-vitro, Pca, DU145
TumCP↓, TumCMig↓, Apoptosis↑, p‑Akt↓, MMP9↓, p‑mTOR↓, TumMeta↓, *antiOx↓, *Inflam↓, *hepatoP↑, *Imm↑, *AntiCan↑,
5208- PI,    Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway
- in-vitro, GC, SNU16 - in-vitro, Nor, GES-1
TumCP↓, Apoptosis↑, BAX↑, BAD↑, Cyt‑c↑, cl‑PARP↑, cl‑Casp3↑, Bcl-2↓, Bcl-xL↓, p‑PI3K↓, p‑Akt↓, Ki-67↓, toxicity↓, RadioS↑,
5216- PI,  doxoR,    Piperine enhances doxorubicin sensitivity in triple-negative breast cancer by targeting the PI3K/Akt/mTOR pathway and cancer stem cells
- vitro+vivo, BC, MDA-MB-231
ChemoSen↑, necrosis↑, PTEN↓, PI3K↓, p‑Akt↓, mTOR↓, ALDH↓, TumVol↓, OS↑, cardioP↑, cl‑PARP↑,
5215- PI,    Piperine impairs cell cycle progression and causes reactive oxygen species-dependent apoptosis in rectal cancer cells
- in-vitro, CRC, NA
TumCCA↑, Apoptosis↑, ROS↑, eff↓, BioEnh↑,
5214- PI,    Piperine induces autophagy of colon cancer cells: Dual modulation of AKT/mTOR signaling pathway and ROS production
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW48 - in-vitro, CRC, SW-620
TumCP↓, TumAuto↑, Akt↓, mTOR↓, ROS↑,
5213- PI,    Induction of apoptosis by piperine in human cervical adenocarcinoma via ROS mediated mitochondrial pathway and caspase-3 activation
- in-vitro, Cerv, HeLa
Apoptosis↑, TumCG↓, ROS↑, MMP↓, DNAdam↑, Casp3↑, TumCCA↑, *Inflam↓, *antiOx↓, *hepatoP↑, ChemoSen↑, CSCs↓,
5211- PI,    Piperine inhibits colorectal cancer migration and invasion by regulating STAT3/Snail-mediated epithelial-mesenchymal transition
- in-vitro, CRC, NA
TumCMig↓, TumCI↓, EMT↓, Snail↓, STAT3↓,
925- PI,    Bioenhancers from mother nature and their applicability in modern medicine
- Review, Nor, NA
*BioEnh↑,
1016- PI,    Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, DLD1
β-catenin/ZEB1↓, Wnt↓, TumCP↓, TumCMig↓, *antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *Bacteria↓, *memory↑, AntiCan↑, NF-kB↓, cFos↓, ATF2↓, CREB↓,
1131- PI,    Piperlongumine‑loaded nanoparticles inhibit the growth, migration and invasion and epithelial‑to‑mesenchymal transition of triple‑negative breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
TumCG↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, Slug↓, N-cadherin↓, β-catenin/ZEB1↓, SMAD3↓, E-cadherin↑, EMT↓,
1059- PI,    Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-Related Events in Human Lung Adenocarcinoma Cells
- in-vitro, Lung, A549 - in-vitro, BC, MDA-MB-231 - in-vitro, Liver, HepG2
EMT↓, p‑ERK↓, p‑SMAD2↓,
4220- PI,    Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination
- in-vivo, AD, NA - in-vivo, MS, NA
*memory↑, *iNOS↓, *NRF2↑, *HO-1↑, *TAC↑, *TNF-α↓, *IL1β↓, *NF-kB↓, *IL10↑, *FOXP3↑, *BDNF↑, other↑,
4221- PI,    Piperine-like alkamides from Piper nigrum induce BDNF promoter and promote neurite outgrowth in Neuro-2a cells
- in-vitro, NA, NA
*Mood↑, *BDNF↑,
4222- PI,    Potential of piperine for neuroprotection in sepsis-associated encephalopathy
- in-vivo, Sepsis, NA
*MMP9↓, *BDNF↑, *memory↑, *neuroP↑,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *eff↑, *BioAv↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑,
3589- PI,    Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models
- in-vivo, Arthritis, NA
*IL6↓, *MMP13↓, *PGE2↓, *AP-1↓, *Inflam↓, *5LO↓, *COX1↓, *COX2↓, *ERK↓, *BioEnh↑,
3595- PI,    Black pepper and health claims: a comprehensive treatise
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *chemoP↑, TumCG↓, *cognitive↑, *MMPs↓, *PGE2↓, *AP-1↓, *5LO↓, *COX1↓, *other↑, *other↑, *other↑, *SOD↑, *Catalase↑, *GSTs↑, *GSR↑, *other↑, *Weight↓, *BioEnh↑, *BioAv↑, *eff↑, *CYP3A2↓, *neuroP↑, *BP↓, *other↑,
3596- PI,    Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
- in-vivo, Nor, NA
*TBARS↑, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *GSH↑, *ROS↓,
3597- PI,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, AD, NA - Review, Park, NA - Review, Var, NA
*NF-kB↓, *MAPK↓, *AP-1↓, *COX2↓, *NOS2↓, *IL1β↓, *TNF-α↓, *PGE2↓, *STAT3↓, *IL10↑, *IL4↓, *IL5↓, P53↑, MMP9↓, MMP2↓, cMyc↓, VEGF↓, STAT3↓, survivin↓, p65↓,
3598- PI,    Piperine attenuates cognitive impairment in an experimental mouse model of sporadic Alzheimer's disease
- in-vivo, AD, NA
*ROS↓, *Inflam↓, *cognitive↑, *Aβ↓, *tau↓,
3599- PI,    Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *neuroP↑, *lipid-P↓, *AChE↓,
3600- PI,    Intranasal piperine-loaded chitosan nanoparticles as brain-targeted therapy in Alzheimer's disease: optimization, biological efficacy, and potential toxicity
- in-vivo, AD, NA
*neuroP↑,
1940- PL,    Piperlongumine Inhibits Migration of Glioblastoma Cells via Activation of ROS-Dependent p38 and JNK Signaling Pathways
- in-vitro, GBM, LN229 - in-vitro, GBM, U87MG
ROS↑, GSH↓, p38↑, JNK↑, IKKα↑, NF-kB↓, eff↓,
1946- PL,  PI,    Piperlonguminine and Piperine Analogues as TrxR Inhibitors that Promote ROS and Autophagy and Regulate p38 and Akt/mTOR Signaling
- in-vitro, Liver, NA
eff↑, toxicity↓, TrxR↓, ROS↑, MMP↓, p38↑, Akt↓, mTOR↓,
1947- PL,    Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer
- in-vitro, GC, SGC-7901 - in-vitro, GC, NA
TrxR1↓, ROS↑, ER Stress↑, mtDam↑, selectivity↑, NO↑, TumCCA↑, mt-ROS↑, Casp9↑, Bcl-2↓, Bcl-xL↓, cl‑PARP↑, eff↓, lipid-P↑,
1948- PL,  BNL,    Natural borneol serves as an adjuvant agent to promote the cellular uptake of piperlongumine for improving its antiglioma efficacy
- in-vitro, GBM, NA
selectivity↑, ROS↑, BioAv↓, BioAv↑, Apoptosis↑, TumCCA↑, eff↑,

Showing Research Papers: 4351 to 4400 of 6108
Prev Page 88 of 123 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6108

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↓, 6,   HO-1↓, 1,   lipid-P↑, 1,   NRF2↓, 1,   ROS↑, 12,   ROS⇅, 1,   mt-ROS↑, 1,   TrxR↓, 1,   TrxR1↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 6,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 2,   CREB↓, 2,  

Cell Death ⓘ

Akt↓, 2,   p‑Akt↓, 3,   Apoptosis↑, 9,   ATF2↓, 2,   BAD↑, 2,   BAX↑, 4,   Bcl-2↓, 4,   Bcl-xL↓, 2,   Casp3↑, 5,   cl‑Casp3↑, 2,   Casp8↑, 3,   Casp9↑, 2,   Cyt‑c↑, 1,   Fas↑, 1,   FasL↑, 1,   JNK↑, 1,   MAPK↑, 2,   Necroptosis↑, 1,   necrosis↑, 1,   p27↑, 1,   p38↓, 1,   p38↑, 2,   survivin↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 3,   cl‑PARP↑, 6,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   cFos↓, 2,   CSCs↓, 1,   EMT↓, 5,   ERK↑, 1,   p‑ERK↓, 1,   mTOR↓, 3,   p‑mTOR↓, 1,   PI3K↓, 1,   p‑PI3K↓, 1,   PTEN↓, 1,   STAT3↓, 3,   STAT3⇅, 1,   TumCG↓, 7,   Wnt↓, 1,  

Migration ⓘ

E-cadherin↓, 2,   E-cadherin↑, 1,   Ki-67↓, 1,   MMP2↓, 3,   MMP9↓, 4,   MMPs↓, 1,   N-cadherin↓, 1,   Slug↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 2,   TumCI↓, 3,   TumCMig↓, 5,   TumCP↓, 7,   TumMeta↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   NO↑, 1,   TXA2↓, 1,   VEGF↓, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   IKKα↑, 1,   IL1β↓, 1,   IL6↓, 2,   Inflam↓, 1,   NF-kB↓, 3,   p50↓, 1,   p65↓, 2,   PGD2↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

ER(estro)↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioEnh↑, 1,   ChemoSen↑, 3,   Dose∅, 3,   eff↓, 4,   eff↑, 6,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

IL6↓, 2,   Ki-67↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 1,   hepatoP↑, 1,   OS↑, 2,   Symptoms∅, 1,   toxicity↓, 3,   TumVol↓, 1,  
Total Targets: 111

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 2,   antiOx↑, 5,   Catalase↓, 1,   Catalase↑, 2,   GPx↑, 1,   GSH↓, 1,   GSH↑, 3,   GSR↑, 1,   GSTs↑, 2,   HO-1↑, 1,   lipid-P↓, 2,   NRF2↑, 1,   ROS↓, 6,   ROS↑, 3,   SOD↓, 1,   SOD↑, 2,   TAC↑, 1,   TBARS↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↑, 1,   cPLA2↓, 1,   CYP3A2↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 1,   MAPK↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 5,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   DNAdam∅, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   GSK‐3β↓, 1,   STAT3↓, 1,  

Migration ⓘ

5LO↓, 2,   AP-1↓, 3,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↑, 1,   Fibronectin↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   Smad7↑, 1,   TGF-β↓, 1,   Vim↓, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,  

Immune & Inflammatory Signaling ⓘ

CD25+↓, 1,   CD69↓, 1,   COX1↓, 2,   COX2↓, 2,   CTLA-4↓, 1,   FOXP3↑, 1,   IFN-γ↓, 1,   IKKα↓, 1,   IL10↑, 2,   IL17↓, 1,   IL1β↓, 2,   IL2↓, 1,   IL4↓, 2,   IL5↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 6,   NF-kB↓, 2,   PGE2↓, 3,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 2,   BDNF↑, 3,   tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 3,   BioEnh↑, 3,   Dose∅, 1,   eff↑, 3,   P450↓, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   BP↓, 1,   IL6↓, 1,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 2,   chemoP↑, 1,   cognitive↑, 3,   hepatoP↑, 5,   memory↑, 5,   Mood↑, 1,   motorD↑, 1,   neuroP↑, 6,   toxicity∅, 1,   Weight↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 101

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page