toxicity Cancer Research Results

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Toxicity
Scientific Papers found: Click to Expand⟱
841- Gra,    The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach
- in-vitro, CRC, HT-29 - in-vitro, Nor, CCD841
PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,
837- Gra,    Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of Annona muricata Linn. in normal and immortalized human cell lines
- in-vitro, BC, MDA-MB-435 - in-vitro, Nor, WRL68 - in-vitro, Nor, HaCaT
*toxicity↓,
851- Gra,    Antiproliferation Activity and Apoptotic Mechanism of Soursop (Annona muricata L.) Leaves Extract and Fractions on MCF7 Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, Nor, CV1
Bcl-2↓, Casp9↑, Casp3↑, other↑, *toxicity↓,
849- Gra,    Annona muricata silver nanoparticles exhibit strong anticancer activities against cervical and prostate adenocarcinomas through regulation of CASP9 and the CXCL1/CXCR2 genes axis
- in-vitro, Pca, PC3 - in-vitro, Nor, PNT1A - in-vitro, NA, HeLa
Casp9↑, CXCL1↓, *toxicity↓,
7335- Gra,    Effect of Annona muricata (Soursop) on Patients with Cancer: A Systematic Review
- Review, Var, NA
TumCG↓, Casp↑, Inflam↓, toxicity↓, other↑, TumCCA↑, Apoptosis↑, TumAuto↑, ATP↓, AIF↑, MMP↓, MOMP↑, Cyt‑c↑, selectivity↑, hepatoP∅,
7324- GSE,    A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention
- Trial, Lung, NA
BioAv↑, toxicity↝, Ki-67↓, miR-106b↓, chemoPv↑, Dose↝, miR-19b↓, PTEN↑, IGF-2R↑, p‑Akt↓, PGE2↓, PGI2↓, COX2/PTGS2↓, Apoptosis↑, TumCP↓, Inflam↓, cardioP↑,
6561- GSL,    Geraniol Pharmacokinetics, Bioavailability and Its Multiple Effects on the Liver Antioxidant and Xenobiotic-Metabolizing Enzymes
- in-vivo, Nor, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiCan↑, *BioAv↝, *Dose↝, *toxicity↓, *Catalase↑, *NADPH↑, *GSR↑, *ALAT∅, *AST∅,
7134- GSL,    Phase I study of oral spirogermanium
- Trial, NA, NA
*Dose↝, toxicity↝, Bil∅, toxicity↝, Dose↓,
7481- H2,  Rad,    Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy
- Trial, Var, NA
Dose↝, CRP↓, NLR↓, IL6↓, AntiTum∅, *toxicity↓, Inflam↓, radioP↑, *IBI↑, *ROS↓,
7487- H2,    A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives
- Review, Nor, NA
*Inflam↓, *antiOx↓, *Stress↓, *Dose↝, *cardioP↑, *GastroP↑, *BBB↑, *eff↑, *toxicity↓, *Dose↝, *hepatoP↑, *ROS↓, *SOD↑, *TBARS↓, *HDL↑, *LDL↓, *Obesity↓, *GSH↑, *TNF-α↓, *GutMicro↑, *DNAdam↓, *γH2AX↓, *p‑p38↓, *NF-kB↓,
7486- H2,    Effects of hydrogen-rich water on blood uric acid in patients with hyperuricemia: A randomized placebo-controlled trial
- Trial, Nor, NA
*eff↑, *uricA↓, *toxicity↓, *antiOx↑, *Inflam↓, *Dose↝, *Dose↝, *Dose↝, *toxicity↓, *Dose↓, *ROS↓,
7488- H2,    Molecular hydrogen therapy: A "democratic" emerging strategy against aging and age-related diseases
- Review, Nor, NA
*antiOx↑, *Inflam↑, *toxicity↓, *AntiAge↑,
7925- H2,    Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice
- in-vivo, Asthma, NA
*Dose?, *IL4↓, *IL13↓, *TNF-α↓, *CXCL15↓, *SOD↑, *MDA↓, *MPO↓, *ROS↓, *antiOx↑, *Inflam↓, *Apoptosis↓, *toxicity↓, *Stroke↓, *Airway↓, *Neut↓, *Eos↓, *BALF-Lym↓, *BALF-Infl↓, *AirwayM↓,
7927- H2,    Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients
- Human, Asthma, NA
*IL8↓, *IL4↓, *IL6↓, *Inflam↓, *Sepsis↓, *Stroke↓, *antiOx↑, *toxicity↓,
2519- H2,    Hydrogen: an advanced and safest gas option for cancer treatment
- Review, Var, NA
antiOx↑, neuroP↓, BBB↑, toxicity∅, TumCP↓, Apoptosis↓, ROS↑, Hif1a↓, NF-kB↓, P53?, OS↑, chemoP↑,
2504- H2,    Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer
- Trial, Lung, NA
CD8+↑, OS↑, eff↝, CoQ10↑, PDT+↓, PGC-1α↑, Dose↝, *toxicity∅,
3768- H2,    Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial
- Trial, AD, NA
*ROS↓, *NO↓, *BACE/β-secretase↓, *BDNF↑, *VEGF↑, *p‑tau↓, *MCP1/CCL2↓, *IL6↓, *cognitive↑, *toxicity∅,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *BP∅, *BBB↑,
1415- HCA,    Hydroxycitrate delays early mortality in mice and promotes muscle regeneration while inducing a rich hepatic energetic status
- in-vivo, Nor, NA
*OS↑, *toxicity↓, *AST∅, *ALAT∅, *Strength↑, *memory∅, *other↑, *other↑, *other↑,
1413- HCA,    Effects of acute (-)-hydroxycitrate supplementation on substrate metabolism at rest and during exercise in humans
- Human, Nor, NA
*toxicity↓,
1625- HCA,    In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase
- Review, Nor, NA
CRM↑, ACLY↓, TumAuto↑, Inflam↓, TumCG↓, toxicity∅, lipoGen↓, *ROS↓, *OCR↓,
1631- HCA,    An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management
- Review, Obesity, NA
*ACLY↓, *toxicity∅, *Dose∅,
1643- HCAs,    Mechanisms involved in the anticancer effects of sinapic acid
- Review, Var, NA
*BioAv↓, *toxicity↓, Dose∅, ROS⇅, ROS↑, Igs↑, TumCCA↑, TumAuto↑, eff↑, angioG↓, TumCI↓, TumMeta↓, EMT↓, Vim↓, MMP9↓, MMP2↓, Snail↓, E-cadherin↑, p‑Akt↓, GSK‐3β↓, TumCP↓, ChemoSen↑,
1438- HCQ,  Chemo,    Adding Chloroquine to Conventional Treatment for Glioblastoma Multiforme
- Trial, GBM, NA
OS↑, *toxicity∅,
7361- HibSad,    Hibiscus sabdariffa L. - a phytochemical and pharmacological review
- Review, Var, NA
*Bacteria↓, *hepatoP↑, *diuretic↑, *LDL↓, *antiOx↑, *ACE/ACE1↓, *Ca+2↝, *toxicity↓, *ROS↓, *RenoP↑,
7352- HibSad,    Efficacy and safety of Hibiscus sabdariffa in cardiometabolic health: An overview of reviews and updated dose-response meta-analysis
- Review, Nor, NA
*BP↓, *toxicity↓,
7453- HNK,    Determination of Potential Lead Compound from Magnolia officinalis for Alzheimer's Disease through Pharmacokinetic Prediction, Molecular Docking, Dynamic Simulation, and Experimental Validation
- Study, AD, NA
*BACE/β-secretase↓, *AChE↓, *QPCT/QC↓, *GSK‐3β↓, *toxicity↓,
2871- HNK,    Antihyperalgesic Properties of Honokiol in Inflammatory Pain Models by Targeting of NF-κB and Nrf2 Signaling
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *VEGF↓, *NRF2↑, *SOD2↑, *HO-1↑, *Inflam↓, *Pain↓, *NO↓, toxicity↓,
2865- HNK,    Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma
- in-vitro, MB, DAOY - vitro+vivo, NA, NA
BioAv↓, BioAv↓, TumCP↓, selectivity↑, P53↑, P21↑, CDK4↓, cycD1/CCND1↓, mtDam↑, ROS↑, eff↓, Casp3↑, BAX↑, LC3II↑, Beclin-1↑, ATG7↑, p62↑, eff↑, ChemoSen↑, *toxicity↓,
2885- HNK,    Honokiol: a novel natural agent for cancer prevention and therapy
NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2/PTGS2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2/PTGS2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,
2895- HNK,    Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity
- in-vitro, Lung, PC9
eff↑, TumCP↓, mt-ROS↑, Prx3↑, mt-STAT3↓, *toxicity∅, selectivity↑, ChemoSen↑,
2079- HNK,    Honokiol Microemulsion Causes Stage-Dependent Toxicity Via Dual Roles in Oxidation-Reduction and Apoptosis through FoxO Signaling Pathway
- in-vitro, Nor, PC12
*toxicity↝, *ROS↓, *ROS↑, *Dose⇅, *BioAv↑, *BioAv↓, *ROS⇅, *SOD↓, *toxicity↑,
7599- HPT,  Rad,    Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome
- Review, Var, NA
NA↑, RadioS↑, DNArepair↓, Hypoxia↓, EPR↑, LC↑, OS↑, *toxicity↓, Dose↝, BloodF↑, pH↝, Imm↑, HSP70/HSPA5↑,
7598- HPT,  Rad,  Chemo,    The role of capacitive hyperthermia as an adjunct treatment in oncology: a systematic review of randomized phase III trials
- Review, Var, NA
OS↑, TR↑, LC↑, *toxicity?,
7622- HPT,    A Review of the Current Clinical Evidence for Loco-Regional Moderate Hyperthermia in the Adjunct Management of Cancers
- Review, Var, NA
LC↑, OS↑, QoL↑, toxicity↓, Dose↝, Dose↝, ROS↑, DNArepair↓, EPR↑, DNAdam↑, HSP70/HSPA5↑, BloodF↑, Hypoxia↓,
7624- HPT,  Chemo,    A multicentre randomised clinical trial of chemoradiotherapy plus hyperthermia versus chemoradiotherapy alone in patients with locally advanced cervical cancer
- Trial, Cerv, NA
OS↑, CR↑, *toxicity↓,
7627- HPT,  Rad,    Local control rate after the combination of re-irradiation and hyperthermia for irresectable recurrent breast cancer: Results in 248 patients
CR↑, OS↑, *toxicity↝, RadioS↑,
7524- HT,    The Pharmaceutical Formulation Plays a Pivotal Role in Hydroxytyrosol Pharmacokinetics
- Trial, Nor, NA
*Dose↝, *BioAv↝, *Half-Life↝, *toxicity↓, *BioAv↝, *BioAv↝,
7542- HT,    Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B - in-vitro, Nor, RWPE-1
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK2↓, CDK4↓, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, tumCV↓, Akt↓, STAT3↓, NF-kB↓, AR↓, ROS↑, mtDam↑, BioAv↓, toxicity↓, eff↑,
4639- HT,    Hydroxytyrosol Induces Apoptosis, Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, p‑Akt↓, p‑STAT3↓, NF-kB↓, AR↓, ROS↑, *BioAv↓, *toxicity∅,
7565- HYP,    Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review
- Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *lipid-P↓, *ROS↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *MDA↓, *BAX↓, *Casp3↓, *Catalase↑, *SOD↑, *GSH↑, *BDNF↑, *TrkB↑, *NGF↑, *BDNF↑, *NF-kB↓, *AChE↓, *H2S↑, Casp3↑, Apoptosis↑, NF-kB↓, AMPK↑, HO-1↑, MAPK↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, SOD?, Catalase↓, NRF2↓, NQO1↓, HO-1↓, Bcl-2↓, TumCCA↑, FOXO1↑, TumAuto↑, Akt↓, mTOR↓, P70S6K↓, BMP7/OP1↓, *cardioP↑, *hepatoP↑, *antiCG↑, *AntiThr↑, *Diar↓, *AntiFungal↑, *CYP2D6↓, *PDGFR-BB↓, *PDGFRB↓, *toxicity↓, *Half-Life↑,
7560- HYP,    Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
- Review, Nor, NA - Review, AD, NA
*RenoP↓, Casp3↑, Casp8↑, MDA↑, GSH↓, SOD↓, Catalase↓, VEGF↓, Bcl-2↓, TumCG↓, p‑Akt↓, PI3K↓, TumCCA↑, TumCP↓, BMP7/OP1↓, *ZO-1↑, *BBB↝, *p‑Akt↑, *GSK‐3β↑, *SOD↑, *Catalase↑, *GSH↑, *SIRT1↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *ROS↓, *MDA↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BDNF↑, *TrkB↑, *NGF↑, *Apoptosis↓, *cardioP↑, *AST↓, *hepatoP↑, *AST↓, *ALAT↓, *MDA↓, *BACH1↓, *neuroP↑, *Stroke↓, *ICAM-1↓, *VCAM-1↓, *TLR4↓, *COX2/PTGS2↓, *RenoP↑, *NLRP3↓, *Casp1↓, *ASC↓, *BioAv↓, *BioAv↑, *toxicity↓,
7602- I3C,    Dose-ranging study of indole-3-carbinol for breast cancer prevention
- Trial, BC, NA
toxicity↓, Dose↝, 2/16-OHE1↑, chemoPv↑,
7583- I3C,    Indole-3-carbinol prevented tumor progression and potentiated PD1ab therapy by upregulating PTEN in colorectal cancer
- vitro+vivo, CRC, NA
TumCP↓, TumCMig↓, toxicity↓, PTEN↑, CD8+↑,
7589- I3C,    Indole-3-carbinol inhibits cell proliferation and induces apoptosis in Hep-2 laryngeal cancer cells
- vitro+vivo, Laryn, HEp2
TumCP↓, Apoptosis↑, PI3K↓, Akt↓, GSK‐3β↓, TumVol↓, *toxicity↓,
7801- IBC,    Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter
- in-vitro, CRC, HT-29
PSEN2/PS-2↓, AntiCan↑, Apoptosis↑, Akt↓, ERK↓, *antiOx↑, *Inflam↓, *neuroP↑, *toxicity↓, selectivity↑,
7578- IMA,    Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia
- Trial, CML, NA
OS↑, toxicity↓, BCR-ABL↓,
7616- Ins,    A phase I study of myo-inositol for lung cancer chemoprevention
- Trial, Nor, NA
*Dose↝, *toxicity↝, *BP↓,
7637- Ins,    Investigating the mechanism of inositol against paclitaxel chemoresistance on triple-negative breast cancer by using 7T multiparametric MRI and mitochondrial changes
- vitro+vivo, BC, 4T1
TumVol↓, Dose↝, *toxicity↓, AMPK↓, Ki-67↓,

Showing Research Papers: 401 to 450 of 698
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 698

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

2/16-OHE1↑, 1,   BMP7/OP1↓, 2,   CR↑, 2,   IGF-2R↑, 1,   LC↑, 3,   miR-106b↓, 1,   NA↑, 1,   NLR↓, 1,   PGI2↓, 1,   PSEN2/PS-2↓, 1,   TR↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Bil∅, 1,   Catalase↓, 2,   CoQ10↑, 1,   GSH↓, 1,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 1,   Prx3↑, 1,   ROS↑, 7,   ROS⇅, 1,   mt-ROS↑, 1,   SIRT3↑, 1,   SOD?, 1,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 1,   BCR-ABL↓, 1,   MMP↓, 2,   mtDam↑, 2,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   AMPK↓, 1,   AMPK↑, 1,   ATG7↑, 1,   CRM↑, 1,   LDH↓, 1,   lipoGen↓, 1,   NADPH↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   p‑Akt↓, 4,   Apoptosis↓, 1,   Apoptosis↑, 7,   BAX↑, 3,   Bax:Bcl2↑, 2,   Bcl-2↓, 4,   Casp↑, 3,   Casp3↑, 6,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 4,   cl‑Casp9↑, 1,   Cyt‑c↑, 3,   MAPK↑, 1,   MOMP↑, 1,   p27/CDKN1B↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   other↑, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3II↑, 1,   p62↑, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   DNArepair↓, 2,   P53?, 1,   P53↑, 1,   cl‑PARP↑, 3,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 3,   CDK4↓, 4,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 2,   P21↑, 2,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 2,   ERK↓, 2,   FOXO1↑, 1,   GSK‐3β↓, 2,   mTOR↓, 2,   p‑mTOR↓, 1,   P70S6K↓, 1,   PI3K↓, 2,   PTEN↑, 3,   RAS↓, 1,   STAT3↓, 2,   p‑STAT3↓, 1,   mt-STAT3↓, 1,   TumCG↓, 4,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   E-cadherin↑, 2,   Ki-67↓, 2,   miR-19b↓, 1,   MMP2↓, 2,   MMP9↓, 2,   N-cadherin↓, 1,   Snail↓, 2,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 11,   TumMeta↓, 3,   Vim↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   EGFR↓, 2,   EPR↑, 2,   Hif1a↓, 1,   Hypoxia↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   CRP↓, 1,   CXCL1↓, 1,   Igs↑, 1,   IL1β↓, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 6,   JAK1↓, 1,   JAK2↓, 1,   NF-kB↓, 6,   PDT+↓, 1,   PGE2↓, 2,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 4,   Dose↓, 1,   Dose↝, 8,   Dose∅, 1,   eff↓, 1,   eff↑, 4,   eff↝, 1,   Half-Life↝, 2,   RadioS↑, 3,   selectivity↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   Bil∅, 1,   BloodF↑, 2,   CRP↓, 1,   EGFR↓, 2,   EZH2↓, 1,   IL6↓, 2,   Ki-67↓, 2,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum∅, 1,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 2,   hepatoP∅, 1,   neuroP↓, 1,   OS↑, 9,   QoL↑, 1,   radioP↑, 1,   toxicity↓, 8,   toxicity↝, 3,   toxicity∅, 2,   TumVol↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 2,  
Total Targets: 170

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

ACE/ACE1↓, 1,   Airway↓, 1,   AirwayM↓, 1,   antiCG↑, 1,   BALF-Infl↓, 1,   BALF-Lym↓, 1,   CXCL15↓, 1,   CYP2D6↓, 1,   diuretic↑, 1,   Eos↓, 1,   IL13↓, 1,   QPCT/QC↓, 1,   Stress↓, 1,   Stroke↓, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 9,   Catalase↑, 4,   GSH↑, 3,   GSR↑, 1,   HDL↑, 1,   HO-1↑, 1,   lipid-P↓, 2,   MDA↓, 6,   MPO↓, 1,   NRF2↑, 2,   ROS↓, 13,   ROS↑, 1,   ROS⇅, 1,   SOD↓, 1,   SOD↑, 4,   SOD1↑, 1,   SOD2↑, 1,   TBARS↓, 1,   uricA↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   mtDam↓, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   ALAT↓, 1,   ALAT∅, 2,   AMPK↑, 1,   H2S↑, 1,   LDL↓, 2,   NADPH↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↑, 1,   Apoptosis↓, 2,   BAX↓, 2,   Bcl-2↑, 1,   Casp1↓, 1,   Casp3↓, 2,   p‑p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   γH2AX↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXO3↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   PDGFRB↓, 1,  

Migration(tgid=13) ⓘ

APP↓, 1,   BACH1↓, 1,   Ca+2↝, 1,   VCAM-1↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 3,   PDGFR-BB↓, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB↝, 1,   GastroP↑, 1,   IBI↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   COX2/PTGS2↓, 1,   ICAM-1↓, 1,   IL1β↓, 4,   IL4↓, 2,   IL6↓, 5,   IL8↓, 3,   Inflam↓, 9,   Inflam↑, 1,   MCP1/CCL2↓, 1,   Neut↓, 1,   NF-kB↓, 3,   TLR4↓, 1,   TNF-α↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BDNF↑, 5,   NGF↑, 2,   p‑tau↓, 1,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 3,   NLRP3↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 2,   BioAv↝, 4,   Dose?, 1,   Dose↓, 1,   Dose⇅, 1,   Dose↝, 9,   Dose∅, 1,   eff↑, 2,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALAT∅, 2,   AST↓, 2,   AST∅, 2,   BP↓, 2,   BP∅, 1,   GutMicro↑, 1,   IL6↓, 5,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   cardioP↑, 3,   cognitive↑, 2,   hepatoP↑, 4,   memory↑, 1,   memory∅, 1,   neuroP↑, 5,   Obesity↓, 1,   OS↑, 1,   Pain↓, 1,   RenoP↓, 1,   RenoP↑, 2,   Strength↑, 1,   toxicity?, 1,   toxicity↓, 29,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 1,   Diar↓, 1,   Sepsis↓, 1,  
Total Targets: 138

Scientific Paper Hit Count for: toxicity, toxicity
31 Silver-NanoParticles
21 Selenium NanoParticles
17 chitosan
16 Magnetic Fields
13 Chemotherapy
13 Dichloroacetate
12 Selenite (Sodium)
12 Sulforaphane (mainly Broccoli)
11 5-Hydroxytryptophan
11 Radiotherapy/Radiation
10 3-bromopyruvate
10 Curcumin
10 EGCG (Epigallocatechin Gallate)
10 Hydrogen Gas
9 Honokiol
9 Phenylbutyrate
8 Cisplatin
8 Copper and Cu NanoParticles
8 Ginkgo biloba-EGb 761
8 Fenbendazole
8 itraconazole
7 Ashwagandha(Withaferin A)
7 Baicalein
7 Berberine
7 Carvacrol
7 Dandelion Root
7 Graviola
6 Apigenin (mainly Parsley)
6 borneol
6 Boron
6 Metformin
6 D-limonene
6 Emodin
6 Eugenol
6 Germanium inorganic
6 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
6 Resveratrol
6 Magnetic Field Rotating
6 Piperlongumine
6 Pterostilbene
6 Selenium
5 Auranofin
5 Allicin (mainly Garlic)
5 HydroxyCitric Acid
5 Artemisinin
5 Capsaicin
5 Ellagic acid
5 Hyperthermia
5 Inositol
5 Lactoferrin/Talactoferrin
5 Shikonin
5 Urolithin
5 Vitamin K2
4 Gold NanoParticles
4 Alpha-Lipoic-Acid
4 beta-glucans
4 Betulinic acid
4 α-Bisabolol / Chamomile oil
4 Celastrol
4 Chlorogenic acid
4 chaetocin
4 Chrysin
4 Cucurbitacin
4 salinomycin
4 Deguelin
4 Disulfiram
4 Folic Acid, Vit B9
4 Fucoidan
4 Gambogic Acid
4 Garcinol
4 Ginkgolic acids
4 Ginkgo biloba
4 Germanium Organic/Ge-132 / propagermanium (organogermanium)
4 Ginger/6-Shogaol/Gingerol
4 isoorientin
4 Kaempferol
4 Propolis -bee glue
4 Phenethyl isothiocyanate
4 Silymarin (Milk Thistle) silibinin
4 Thymoquinone
3 Vitamin C (Ascorbic Acid)
3 SonoDynamic Therapy UltraSound
3 Anti-oxidants
3 doxorubicin
3 Atorvastatin
3 Baicalin
3 Beta-Caryophyllene
3 Bullatacin
3 Carnosine
3 Centella asiatica / Gotu kola → asiaticoside
3 Chlorophyllin
3 Cinnamon
3 Diclofenac
3 Docosahexaenoic Acid
3 diet FMD Fasting Mimicking Diet
3 Oxygen, Hyperbaric
3 Ivermectin
3 Gallic acid
3 Geldanamycin
3 Genistein (soy isoflavone)
3 Ginkgetin
3 Gossypol/AT-101
3 HydroxyTyrosol
3 Indole-3-carbinol
3 Isoliquiritigenin
3 Licochalcone A
3 Magnolol
3 Melatonin
3 Bicarbonate(Sodium)
3 Niclosamide (Niclocide)
3 Quercetin
3 Rosmarinic acid
3 Sulfasalazine
2 Astragalus
2 Zinc
2 Ascorbyl Palmitate
2 Paclitaxel/Taxol
2 Arsenic trioxide
2 Aloe anthraquinones
2 Berbamine
2 brusatol
2 Bacopa monnieri
2 Boswellia (frankincense)
2 Thymol-Thymus vulgaris
2 carboplatin
2 Hydroxycinnamic-acid
2 Coenzyme Q10
2 Vitamin E
2 CUSP9
2 Docetaxel
2 Lemongrass Extract/Citral
2 immunotherapy
2 Echinacea
2 Estragole
2 Fennel Oil/Foeniculum vulgare
2 Evodiamine
2 Ferulic acid
2 Flickering Light Stimulation
2 Formononetin
2 Shilajit/Fulvic Acid
2 Gamma-aminobutyric acid
2 Germanium-Spirogermanium
2 Germacranolide sesquiterpene lactone
2 Hibiscus sabdariffa
2 Hyperoside
2 isoflavones
2 isoquercitrin
2 Laetrile B17 Amygdalin
2 Lapatinib
2 Luteolin
2 Lycopene
2 metronomic chemo
2 Propyl gallate
2 Piperine
2 Psoralidin
2 Ramucirumab (CYRAMZA)
2 EMF
2 Terpinen-4-ol / Tea Tree Oil
2 tetrathiomolybdate
2 Whole Body Vibration
1 1,8-Cineole
1 Resiquimod
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 5-Aminolevulinic acid
1 Aspirin
1 Astaxanthin
1 Dipyridamole
1 Biochanin A
1 Bufalin/Huachansu
1 Brucea javanica
1 Bromelain
1 Bruteridin(bergamot juice)
1 Butyrate
1 Carnosic acid
1 Catechins
1 Cat’s Claw
1 Celecoxib
1 Chocolate
1 Cichoric acid / Chicoric acid
1 Citric Acid
1 Carica papaya leaf extract
1 Camptothecin
1 irinotecan
1 Crocetin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Black phosphorus
1 chemodynamic therapy
1 Cynaropicrin
1 Cysteamine
1 diet Fermented Foods
1 diet Ketogenic
1 diet Methionine-Restricted Diet
1 Protocatechuic acid
1 ferumoxytol
1 Fisetin
1 Auditory Gamma Stimulation / 40 Hz Auditory Stimulation
1 Vitamin D3
1 Ginkgolide B
1 Grapeseed extract
1 hydroxychloroquine
1 Isobavachalcone
1 imatinib
1 Inulin Prebiotic
1 Isovitexin
1 Juglone
1 L-ornithine
1 Trastuzumab
1 Lapachol
1 Lasiodin
1 Linalool
1 MCToil
1 Methyl Jasmonate
1 Methyl salicylate / Sweet Birch oil
1 magnetic nanoparticles
1 Moringa oleifera
1 Mushroom Lion’s Mane
1 nicotinamide adenine dinucleotide
1 Naringin
1 Oleuropein
1 Peppermint
1 5-fluorouracil
1 sericin
1 Sanguinarine
1 Plumbagin
1 probiotics
1 Bifidobacterium
1 benzo(a)pyrene
1 Rauwolfia serpentina/Indian Snakeroot
1 Rutin
1 buckwheat sprouts
1 α-Santalol/Sandalwood oil
1 Date Fruit Extract
1 Taurine
1 Aflavin-3,3′-digallate
1 Turmerones
1 Vitamin B1/Thiamine
1 Vitexin
1 Wogonin
1 Xylitol
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1025  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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