toxicity Cancer Research Results

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Type:
Toxicity
Scientific Papers found: Click to Expand⟱
7112- GEO2,    Hazard assessment of germanium supplements
- Review, Var, NA
toxicity↝, RenoP↓, NP/CIPN↑, Dose↝,
7113- GEO2,    Nephrotoxicity and neurotoxicity in humans from organogermanium compounds and germanium dioxide
- Review, Nor, NA
*Dose↓, *Dose↑, *toxicity↑, *creat↑, *Dose↑, *other?,
7116- GEO2,    Analytical product study of germanium-containing medicine by different ICP-MS applications
- Study, Nor, NA
*toxicity↓, *toxicity↑,
7120- GEO2,    Germanium dioxide-induced nephropathy: a new type of renal disease
- Human, Var, NA
toxicity↑,
7121- GEO2,    Subacute nephrotoxicity of germanium dioxide in the experimental animal
- in-vivo, Nor, NA
toxicity↑, *creat↑, *BUN↑, *other↑,
7122- GEO2,    Nephrotoxicity of germanium compounds: report of a case and review of the literature
- Case Report, Var, NA
toxicity↑,
7115- GeS,    A phase II study of spirogermanium as second line therapy in patients with poor prognosis lymphoma. An NCI Canada Clinical Trials Group Study
- Trial, lymphoma, NA
eff↓, toxicity↝,
7114- GeS,    A phase II study of spirogermanium in advanced human malignancy
- Human, Var, NA
*toxicity↝,
7286- GGB,    Ginsenoside Rh2 shifts tumor metabolism from aerobic glycolysis to oxidative phosphorylation through regulating the HIF1-α/PDK4 axis in non-small cell lung cancer
- in-vitro, Lung, A549 - in-vitro, Lung, PC9
Hif1a↓, Glycolysis↓, OXPHOS↑, ROS↑, Apoptosis↑, toxicity↓, PDKs↓, HK2↓, LDHA↓, PFKFB2↓, PKM2↓, Synergy↑,
7145- GI,  Chemo,    Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin-cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study
- Trial, BC, NA
Dose↝, toxicity∅, Nausea∅, Vomit∅,
7155- GI,  BSB,    Effect of Ginger and Chamomile on Nausea and Vomiting Caused by Chemotherapy in Iranian Women with Breast Cancer
- Trial, BC, NA
Dose↝, Dose↝, Vomit↓, Nausea↓, *toxicity↓,
7158- GI,    Ginger-partitioned moxibustion in the prevention of nausea and vomiting induced by chemotherapy in lung cancer：a randomized controlled trial
- Trial, Lung, NA
Vomit↓, Nausea↓, toxicity↓, other↝,
7137- GI,    6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - vitro+vivo, Pca, HMVP2
STAT3↓, TNF-α↓, NF-kB↓, cycD1/CCND1↓, survivin↓, cMyc↓, IL7↓, RANTES↓, BAX↑, Bcl-2↓, P21↑, p27/CDKN1B↑, SOCS1↑, IRF1↑, eff↑, TumVol↓, TumW↓, toxicity↓,
7243- Gink,    Integrating network pharmacology prediction and experimental investigation to verify ginkgetin anti-invasion and metastasis of human lung adenocarcinoma cells via the Akt/GSK-3β/Snail and Wnt/β-catenin pathwa
- vitro+vivo, Lung, A549 - in-vitro, Lung, H1299
TumCI↓, TumMeta↓, Akt↓, GSK‐3β↓, Snail↓, Wnt↓, β-catenin/ZEB1↓, *toxicity↓,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
7260- Gink,    Ginkgetin: A natural biflavone with versatile pharmacological activities
- Review, Var, NA - Review, Stroke, NA - Review, AD, NA
*AntiCan↑, *Inflam↓, *AntiBio↑, *neuroP↑, *TumCCA↑, Apoptosis↑, TumAuto↑, iNOS↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PLA2↓, *neuroP↑, *Stroke↓, *AntiFungal↓, *Bacteria↓, Bcl-xL↓, Bcl-2↓, Casp9↑, Casp3↑, cl‑PARP↑, IL6↓, STAT3↓, JAK1↓, survivin↓, COX2/PTGS2↓, IAP1↓, MMP2↓, MMP9↓, PTEN↑, SHP1↑, Synergy↑, TumVol↓, TumW↓, *toxicity↓, *ROS↓,
7305- GoldNP,  Rad,    The use of gold nanoparticles to enhance radiotherapy in mice
- in-vivo, Var, NA
Dose↝, selectivity↑, toxicity↝, RadioS↑,
7304- GoldNP,    Phase I and Pharmacokinetic Studies of CYT-6091, a Novel PEGylated Colloidal Gold-rhTNF Nanomedicine
- Study, Var, NA
Dose↝, toxicity↝, Dose↑,
7320- Gos,    AT-101 Enhances the Antitumor Activity of Lenalidomide in Patients with Multiple Myeloma
- Trial, Melanoma, NA
Bcl-2↓, Mcl-1↓, Apoptosis↑, Synergy↑, toxicity↝, ORR↑,
7316- Gos,  PacT,  carbop,  Chemo,    A phase I study of AT-101, a BH3 mimetic, in combination with paclitaxel and carboplatin in solid tumors
- Trial, Var, NA
Bcl-2↓, Bcl-xL↓, Mcl-1↓, Dose↝, toxicity↝,
7311- Gos,    Systematic Review of Gossypol/AT-101 in Cancer Clinical Trials
- Review, CLL, NA
Dose↝, toxicity↓, PFS↓, OS↑, Synergy↑, BioAv↑, Bcl-2↓, ROS↑, MOMP↑, Dose↑, Casp3↑, Casp9↑, MMP↑, VEGF↓, APE1/APEX1↓, ChemoSen↑, RadioS↑, toxicity↑, AST↑, ALAT↑,
7335- Gra,    Effect of Annona muricata (Soursop) on Patients with Cancer: A Systematic Review
- Review, Var, NA
TumCG↓, Casp↑, Inflam↓, toxicity↓, other↑, TumCCA↑, Apoptosis↑, TumAuto↑, ATP↓, AIF↑, MMP↓, MOMP↑, Cyt‑c↑, selectivity↑, hepatoP∅,
843- Gra,    Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling
- in-vitro, NMSC, A431 - in-vitro, NMSC, UW-BCC1 - in-vitro, Nor, NHEKn
TumCG↓, TumCCA↑, Cyc↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, Sufu↑, BAX↑, Bcl-2↓, *toxicity↓,
842- Gra,    Phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata (Graviola)
- in-vitro, NA, NA - in-vitro, Nor, NA
other↓, *toxicity↓,
841- Gra,    The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach
- in-vitro, CRC, HT-29 - in-vitro, Nor, CCD841
PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,
837- Gra,    Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of Annona muricata Linn. in normal and immortalized human cell lines
- in-vitro, BC, MDA-MB-435 - in-vitro, Nor, WRL68 - in-vitro, Nor, HaCaT
*toxicity↓,
851- Gra,    Antiproliferation Activity and Apoptotic Mechanism of Soursop (Annona muricata L.) Leaves Extract and Fractions on MCF7 Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, Nor, CV1
Bcl-2↓, Casp9↑, Casp3↑, other↑, *toxicity↓,
849- Gra,    Annona muricata silver nanoparticles exhibit strong anticancer activities against cervical and prostate adenocarcinomas through regulation of CASP9 and the CXCL1/CXCR2 genes axis
- in-vitro, Pca, PC3 - in-vitro, Nor, PNT1A - in-vitro, NA, HeLa
Casp9↑, CXCL1↓, *toxicity↓,
7324- GSE,    A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention
- Trial, Lung, NA
BioAv↑, toxicity↝, Ki-67↓, miR-106b↓, chemoPv↑, Dose↝, miR-19b↓, PTEN↑, IGF-2R↑, p‑Akt↓, PGE2↓, PGI2↓, COX2/PTGS2↓, Apoptosis↑, TumCP↓, Inflam↓, cardioP↑,
6561- GSL,    Geraniol Pharmacokinetics, Bioavailability and Its Multiple Effects on the Liver Antioxidant and Xenobiotic-Metabolizing Enzymes
- in-vivo, Nor, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiCan↑, *BioAv↝, *Dose↝, *toxicity↓, *Catalase↑, *NADPH↑, *GSR↑, *ALAT∅, *AST∅,
7134- GSL,    Phase I study of oral spirogermanium
- Trial, Var, NA
*Dose↝, toxicity↝, Bil∅, toxicity↝, Dose↓,
7481- H2,  Rad,    Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy
- Trial, Var, NA
Dose↝, CRP↓, NLR↓, IL6↓, AntiTum∅, *toxicity↓, Inflam↓, radioP↑, *IBI↑, *ROS↓,
7486- H2,    Effects of hydrogen-rich water on blood uric acid in patients with hyperuricemia: A randomized placebo-controlled trial
- Trial, Nor, NA
*eff↑, *uricA↓, *toxicity↓, *antiOx↑, *Inflam↓, *Dose↝, *Dose↝, *Dose↝, *toxicity↓, *Dose↓, *ROS↓,
7487- H2,    A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives
- Review, Nor, NA
*Inflam↓, *antiOx↓, *Stress↓, *Dose↝, *cardioP↑, *GastroP↑, *BBB↑, *eff↑, *toxicity↓, *Dose↝, *hepatoP↑, *ROS↓, *SOD↑, *TBARS↓, *HDL↑, *LDL↓, *Obesity↓, *GSH↑, *TNF-α↓, *GutMicro↑, *DNAdam↓, *γH2AX↓, *p‑p38↓, *NF-kB↓, *antiAll↑,
7488- H2,    Molecular hydrogen therapy: A "democratic" emerging strategy against aging and age-related diseases
- Review, Nor, NA
*antiOx↑, *Inflam↑, *toxicity↓, *AntiAge↑,
7927- H2,    Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients
- Human, Asthma, NA
*IL8↓, *IL4↓, *IL6↓, *Inflam↓, *Sepsis↓, *Stroke↓, *antiOx↑, *toxicity↓, *antiAll↑,
7925- H2,    Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice
- in-vivo, Asthma, NA
*Dose?, *IL4↓, *IL13↓, *TNF-α↓, *CXCL15↓, *SOD↑, *MDA↓, *MPO↓, *ROS↓, *antiOx↑, *Inflam↓, *Apoptosis↓, *toxicity↓, *Stroke↓, *Airway↓, *Neut↓, *Eos↓, *BALF-Lym↓, *BALF-Infl↓, *AirwayM↓, *antiAll↑,
3768- H2,    Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial
- Trial, AD, NA
*ROS↓, *NO↓, *BACE/β-secretase↓, *BDNF↑, *VEGF↑, *p‑tau↓, *MCP1/CCL2↓, *IL6↓, *cognitive↑, *toxicity∅,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *BP∅, *BBB↑,
2519- H2,    Hydrogen: an advanced and safest gas option for cancer treatment
- Review, Var, NA
antiOx↑, neuroP↓, BBB↑, toxicity∅, TumCP↓, Apoptosis↓, ROS↑, Hif1a↓, NF-kB↓, P53?, OS↑, chemoP↑,
2504- H2,    Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer
- Trial, Lung, NA
CD8+↑, OS↑, eff↝, CoQ10↑, PDT+↓, PGC-1α↑, Dose↝, *toxicity∅,
294- HCA,    In Vitro and In Vivo Toxicity of Garcinia or Hydroxycitric Acid: A Review
- Review, Nor, NA
toxicity↓,
1415- HCA,    Hydroxycitrate delays early mortality in mice and promotes muscle regeneration while inducing a rich hepatic energetic status
- in-vivo, Nor, NA
*OS↑, *toxicity↓, *AST∅, *ALAT∅, *Strength↑, *memory∅, *other↑, *other↑, *other↑,
1413- HCA,    Effects of acute (-)-hydroxycitrate supplementation on substrate metabolism at rest and during exercise in humans
- Human, Nor, NA
*toxicity↓,
1631- HCA,    An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management
- Review, Obesity, NA
*ACLY↓, *toxicity∅, *Dose∅,
1625- HCA,    In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase
- Review, Nor, NA
CRM↑, ACLY↓, TumAuto↑, Inflam↓, TumCG↓, toxicity∅, lipoGen↓, *ROS↓, *OCR↓,
1643- HCAs,    Mechanisms involved in the anticancer effects of sinapic acid
- Review, Var, NA
*BioAv↓, *toxicity↓, Dose∅, ROS⇅, ROS↑, Igs↑, TumCCA↑, TumAuto↑, eff↑, angioG↓, TumCI↓, TumMeta↓, EMT↓, Vim↓, MMP9↓, MMP2↓, Snail↓, E-cadherin↑, p‑Akt↓, GSK‐3β↓, TumCP↓, ChemoSen↑,
1438- HCQ,  Chemo,    Adding Chloroquine to Conventional Treatment for Glioblastoma Multiforme
- Trial, GBM, NA
OS↑, *toxicity∅,
7361- HibSad,    Hibiscus sabdariffa L. - a phytochemical and pharmacological review
- Review, Var, NA
*Bacteria↓, *hepatoP↑, *diuretic↑, *LDL↓, *antiOx↑, *ACE/ACE1↓, *Ca+2↝, *toxicity↓, *ROS↓, *RenoP↑,
7352- HibSad,    Efficacy and safety of Hibiscus sabdariffa in cardiometabolic health: An overview of reviews and updated dose-response meta-analysis
- Review, Nor, NA
*BP↓, *toxicity↓,

Showing Research Papers: 401 to 450 of 817
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 817

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 14,   Bil∅, 1,   Catalase↓, 5,   Catalase↑, 5,   Copper↓, 1,   CoQ10↑, 1,   ENOX2↓, 1,   Fenton↑, 6,   GPx↓, 2,   GPx↑, 2,   GPx4↓, 9,   GSH↓, 35,   GSH↑, 1,   GSH/GSSG↓, 3,   GSR↑, 1,   GSSG↑, 2,   GSTs↑, 2,   H2O2↑, 8,   i-H2O2↓, 1,   mt-H2O2↑, 1,   HNE↑, 1,   HO-1↓, 6,   HO-1↑, 10,   Iron↓, 1,   Iron↑, 4,   i-Iron↑, 2,   Keap1↑, 2,   lipid-P?, 1,   lipid-P↓, 6,   lipid-P↑, 12,   MDA↓, 2,   MDA↑, 11,   MPO↓, 1,   mt-NADH↓, 1,   NADHdeh?, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↓, 3,   NQO1↑, 6,   NRF2↓, 12,   NRF2↑, 13,   NRF2↝, 1,   Prx↓, 1,   Prx3↑, 1,   PrxI∅, 1,   ox-PrxI↑, 1,   PrxII↓, 1,   PrxII↑, 1,   PrxII∅, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 15,   ROS↑, 210,   ROS⇅, 4,   ROS↝, 2,   ROS∅, 2,   i-ROS?, 1,   i-ROS↑, 3,   mt-ROS↑, 9,   selenoP↑, 1,   SOD?, 1,   SOD↓, 8,   SOD↑, 5,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 3,   TAC↓, 1,   Thiols↓, 2,   TOS↑, 1,   Trx↓, 2,   TrxR↓, 7,   TrxR1↓, 1,   TrxR1⇅, 1,   mt-TrxR1↓, 1,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   FTH1↓, 1,   IronCh↑, 2,   IronCh∅, 1,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 4,   CDC25↓, 3,   compI↓, 8,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   ETC↓, 7,   ETC↑, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 2,   MFN2↑, 1,   mitResp↓, 4,   mitResp↑, 1,   MKK7↓, 1,   mtDam?, 1,   mtDam↓, 1,   mtDam↑, 22,   OCR↓, 3,   OCR↑, 3,   OXPHOS↓, 3,   OXPHOS↑, 7,   OXPHOS↝, 1,   mt-OXPHOS↓, 2,   mt-OXPHOS↑, 1,   PDH↓, 1,   p‑PDH↓, 1,   p‑PDH↑, 1,   PGC-1α↑, 2,   PINK1↑, 1,   SDH↓, 1,   SIRT3↑, 3,   mt-TrxR2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↓, 1,   ACLY↓, 1,   ACSL4↑, 3,   Alanine↓, 1,   ALAT↓, 3,   ALAT↑, 1,   AMP↓, 1,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 11,   AMPK↝, 2,   p‑AMPK↑, 3,   ATP↓, 22,   CRM↑, 1,   ECAR↓, 3,   ECAR∅, 1,   FAO↑, 1,   FASN↓, 1,   GAPDH↓, 2,   GLS↓, 1,   glucoNG↓, 1,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↓, 10,   GlucoseCon↑, 1,   GlutaM↓, 1,   GlutMet↓, 1,   Glycine↓, 1,   Glycolysis↓, 37,   Glycolysis↝, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 3,   HK2?, 1,   HK2↓, 12,   HMG-CoA↓, 3,   KeyT↑, 1,   lactateProd↓, 13,   lactateProd↑, 3,   LDHA↓, 5,   LDL↓, 3,   lipoGen↓, 4,   NADH:NAD↓, 1,   NADPH↓, 3,   NADPH↑, 1,   PDK1 / PDPK1↓, 6,   PDKs↓, 8,   p‑PDKs↓, 1,   PFK↓, 1,   PFK1↓, 1,   PFKFB3↓, 1,   PKM1↑, 1,   PKM2↓, 7,   PKM2↑, 1,   PLA2↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 3,   TCA↑, 1,   Warburg↓, 8,  

Cell Death(tgid=5) ⓘ

AIF↑, 6,   APAF1↑, 1,   Apoptosis↓, 3,   Apoptosis↑, 178,   mt-Apoptosis↑, 1,   BAD?, 1,   BAD↓, 1,   BAD↑, 3,   Bak↓, 1,   Bak↑, 5,   BAX↑, 64,   Bax:Bcl2↑, 16,   Bcl-2↓, 69,   Bcl-2↑, 1,   Bcl-xL↓, 12,   Bcl-xL↑, 2,   BID↑, 3,   BIM↑, 4,   Casp↓, 1,   Casp↑, 24,   Casp1↑, 2,   Casp3?, 1,   Casp3↓, 1,   Casp3↑, 82,   cl‑Casp3↓, 1,   cl‑Casp3↑, 26,   cl‑Casp3⇅, 1,   proCasp3↓, 1,   pro‑Casp3↑, 1,   Casp7?, 1,   Casp7↑, 8,   cl‑Casp7↑, 2,   Casp8↑, 28,   Casp8∅, 1,   cl‑Casp8↑, 4,   Casp9?, 1,   Casp9↑, 52,   cl‑Casp9↓, 1,   cl‑Casp9↑, 11,   CellShr↑, 2,   cFLIP↓, 1,   Cupro↑, 2,   Cyt‑c↑, 51,   cl‑Cyt‑c↑, 1,   Diablo↑, 1,   DR5↑, 11,   DR5↝, 1,   FADD↑, 3,   Fas↓, 1,   Fas↑, 8,   FasL↓, 1,   FasL↑, 4,   Ferroptosis↑, 15,   GSDMC↑, 1,   GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 1,   iNOS↓, 10,   Mcl-1↓, 12,   MDM2↓, 2,   MDM2↑, 1,   MOMP↑, 4,   Necroptosis↑, 2,   necrosis↑, 5,   p38↓, 2,   p38↑, 11,   p‑p38↓, 2,   p‑p38↑, 4,   Paraptosis↑, 2,   PUMA↑, 1,   Pyro↑, 4,   survivin↓, 28,   TNFR 1↑, 1,   TRAIL↑, 2,   TumCD↓, 1,   TumCD↑, 28,   XIAP↓, 10,   XIAP↑, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 74,   Akt↑, 2,   p‑Akt↓, 24,   p‑Akt↑, 1,   BRAF↑, 1,   CaMKII ↓, 1,   CIP2A↓, 1,   cMET↓, 3,   CREB↓, 1,   CREB2↓, 1,   cSrc↓, 1,   EGFR↓, 18,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 20,   ERK↑, 5,   p‑ERK↓, 6,   GNAI1↓, 1,   HER2/EBBR2↓, 8,   p‑HER2/EBBR2↓, 1,   Hippo↑, 1,   IGF-1R↓, 3,   p‑IGF-1R↓, 1,   IGF-2R↑, 1,   IKKα↓, 4,   JAK↓, 1,   JAK1↓, 4,   JAK2↓, 9,   p‑JAK2↓, 1,   JNK↓, 1,   JNK↑, 8,   p‑JNK↑, 3,   LIFR/CD118↓, 1,   LIMK1↓, 1,   MAPK↓, 17,   MAPK↑, 10,   MAPK↝, 1,   MARK4↓, 1,   MEK↓, 1,   MKK4↓, 1,   mTOR?, 1,   mTOR↓, 50,   mTOR↑, 1,   mTOR↝, 2,   p‑mTOR↓, 4,   p70S6↓, 1,   p‑p70S6↓, 1,   P70S6K↓, 3,   P90RSK↓, 2,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PFKFB2↓, 1,   PI3K?, 1,   PI3K↓, 58,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 4,   PI3K/Akt↓, 1,   PI3k/Akt/mTOR↓, 1,   PI3k/Akt/mTOR↝, 1,   PKA↓, 2,   PKCδ↓, 2,   p‑PKCδ↓, 1,   PP2A↑, 1,   PTEN↓, 1,   PTEN↑, 15,   Raf↓, 1,   c-Raf↓, 1,   RAS↓, 7,   p‑RSK↑, 1,   SHP1↑, 1,   Sp1/3/4↓, 5,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 4,   STAT3↓, 45,   STAT3↑, 1,   p‑STAT3↓, 3,   p‑STAT3↑, 1,   mt-STAT3↓, 1,   STAT4↑, 1,   STAT5↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↑, 1,   ATF4↑, 6,   CBP↓, 1,   ChrMod↑, 1,   cJun↓, 4,   cJun↑, 2,   p‑cJun↑, 1,   cMyc↓, 11,   p‑cMyc↑, 1,   DNMT1↓, 4,   DNMT3A↓, 3,   DNMT3B↓, 1,   DNMTs↓, 6,   EZH2↓, 3,   FOXO1↑, 3,   FOXO3↑, 3,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↑, 2,   H3↓, 1,   H3↑, 1,   ac‑H3↑, 3,   ac‑H4↑, 2,   HATs↓, 3,   HATs↑, 1,   HDAC↓, 14,   HDAC↑, 1,   HDAC1↓, 3,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC6↓, 1,   HDAC8↓, 3,   HES1↓, 1,   IRF1↑, 1,   miR-106b↓, 2,   miR-107↑, 1,   miR-139-5p↑, 1,   miR-155↓, 2,   miR-19b↓, 2,   miR-200b↑, 1,   miR-200c↑, 1,   miR-203↑, 1,   miR-21↓, 2,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-30a-5p↑, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 2,   miR-375↑, 1,   miR-422a↑, 1,   Myc↓, 3,   MYCN↓, 1,   OCT4↓, 7,   other?, 1,   other↓, 7,   other↑, 18,   other↝, 40,   other∅, 1,   PhotoS↑, 1,   Prot↓, 1,   SD↑, 3,   SD↝, 1,   sonoS↑, 1,   SOX2↓, 3,   SOX4↓, 1,   SOX9↓, 1,   SUMO↓, 1,   SUV39H↓, 2,   tumCV↓, 49,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   CHOP/DDIT3↑, 9,   CHOP/DDIT3↝, 1,   eIF2α↑, 2,   p‑eIF2α↑, 2,   ER Stress↑, 26,   ER Stress↝, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 5,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 2,   HSP90↓, 14,   ac‑HSP90↑, 1,   HSPs↑, 1,   HTRA↓, 1,   IRE1↑, 1,   PERK↑, 7,   PSMB5↓, 1,   UPR↑, 7,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   ATG7↑, 3,   Beclin-1/ATG6↑, 10,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 1,   LC3B-II↑, 2,   LC3II↑, 5,   LC3s↓, 1,   MitoP↑, 1,   p62↓, 6,   p62↑, 4,   PARK2↑, 1,   TumAuto↓, 1,   TumAuto↑, 45,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   BRCA1↓, 1,   DFF45↓, 1,   DNA-PK↑, 2,   DNAdam↑, 48,   DNArepair↓, 4,   DNArepair↑, 2,   hTERT/TERT↓, 4,   p16↑, 1,   P53?, 1,   P53↓, 3,   P53↑, 35,   p‑P53↑, 1,   p53 Wildtype↓, 1,   p73↑, 1,   PARP↓, 1,   PARP↑, 18,   cl‑PARP↑, 35,   PARP1↓, 1,   PARP1↑, 1,   cl‑PARP1↑, 2,   PCNA↓, 15,   RAD51↓, 1,   Telomerase↓, 6,   TOP1↓, 4,   TOP1↝, 1,   TOP2↓, 1,   TOP2↑, 1,   γH2AX↑, 8,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 6,   CDK1↑, 1,   CDK2↓, 19,   CDK4↓, 24,   CDK4/6↓, 1,   CDK6↓, 4,   CDK8↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 1,   Chk2↓, 1,   ChrCon↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 10,   cycD1/CCND1↓, 32,   cycE/CCNE↓, 12,   cycE1↓, 1,   E2Fs↓, 4,   FBXO5/EMI1↓, 1,   Ki-67↓, 24,   mitA↑, 2,   p19↑, 1,   P21↓, 3,   P21↑, 30,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 8,   pRB↓, 2,   p‑pRB↓, 3,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 3,   TubPol↓, 1,   TumCCA?, 1,   TumCCA↓, 1,   TumCCA↑, 133,   β-Tubulin↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   AXIN1↑, 2,   BMI1↓, 1,   BMP7/OP1↓, 2,   CD133↓, 1,   cFos↓, 4,   CSCs?, 1,   CSCs↓, 27,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↑, 8,   EIF4E↓, 1,   FGF↓, 1,   Gli1↓, 3,   HH↓, 7,   HMGCR↓, 2,   IGF-1↓, 7,   IGF-1↑, 1,   IGFBP1↑, 1,   IGFBP3↑, 1,   JAG1↓, 1,   Ki-67↓, 24,   Let-7↑, 1,   LRP6↓, 1,   mTORC1↓, 3,   Nanog↓, 4,   NICD↓, 1,   NOTCH↓, 9,   NOTCH1↓, 8,   OGF↑, 1,   OGFr↑, 3,   p300↓, 1,   Piezo1↑, 1,   PTCH1↓, 1,   SCF↓, 1,   Shh↓, 2,   Smo↓, 3,   STAT1↓, 1,   Sufu↑, 1,   TAZ↓, 1,   TumCG?, 4,   TumCG↓, 126,   TumCG↑, 2,   TumCP↓, 129,   TumCP↑, 1,   TumCP∅, 1,   Wnt↓, 26,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↑, 1,   AP-1↓, 3,   AP-1↑, 1,   ATPase↓, 1,   BACH1↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 15,   Ca+2↝, 3,   i-Ca+2↓, 1,   Cal9↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cofilin↓, 1,   p‑Cofilin↑, 1,   COL1↓, 1,   decorin↑, 1,   DLC1↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 21,   EM↑, 1,   EMT↓, 42,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 3,   FAK↑, 1,   p‑FAK↓, 3,   fascin↓, 1,   Fibronectin↓, 1,   GLI2↓, 2,   GLI3↓, 1,   GLI3↑, 1,   ITGB1↓, 1,   ITGB4↓, 1,   ITGB6↓, 1,   KRAS↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MMP1↓, 2,   MMP15↓, 1,   MMP16↓, 1,   MMP2↓, 42,   MMP3↓, 3,   MMP7↓, 2,   MMP9↓, 50,   MMPs↓, 14,   N-cadherin↓, 11,   N-cadherin↑, 1,   NEDD9↓, 1,   PCBP1↓, 1,   PDGF↓, 2,   RECK↑, 1,   Rho↓, 2,   ROCK1↓, 2,   Slug↓, 8,   Smad1↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 1,   p‑SMAD3↓, 1,   Snail↓, 11,   TGF-β↓, 7,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 3,   pol-TregCell↓, 1,   TRIB3↑, 1,   TSP-1↑, 3,   TumCA↓, 1,   TumCA↑, 1,   TumCI↓, 62,   TumCMig↓, 62,   TumMeta↓, 43,   TumMeta↑, 6,   TumMeta∅, 1,   Twist↓, 11,   TXNIP↓, 1,   uPA↓, 4,   Vim↓, 14,   Zeb1↓, 2,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 26,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 79,   angioG↑, 2,   CD31/PECAM-1↓, 4,   Endoglin↓, 1,   HIF-1↓, 3,   Hif1a↓, 38,   Hif1a↑, 1,   Hypoxia↓, 2,   LOX1↓, 2,   NO↓, 1,   NO↑, 5,   PGI2↓, 1,   VCAM-1↓, 4,   VEGF↓, 53,   VEGF↑, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 10,   VEGFR2/KDR/Flk1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 11,   BBB∅, 1,   CLDN1↓, 2,   CLDN1↑, 1,   EPR↑, 13,   GLUT1↓, 7,   GLUT4↓, 1,   IBI↑, 1,   LAT↓, 1,   MMP?, 1,   MMP↓, 77,   MMP↑, 2,   MPT↑, 5,   NHE1↓, 1,   OCLN↑, 1,   SLC12A5↓, 2,   sonoP↑, 1,   TJ↓, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CD4+↑, 4,   CD44↓, 5,   CD47↓, 1,   CD8+↑, 5,   COX1↓, 1,   COX2/PTGS2↓, 44,   COX2/PTGS2↑, 2,   CXCL1↓, 1,   CXCL9↓, 1,   CXCR4↓, 5,   DCells↑, 2,   DR4↑, 3,   FOXP3↑, 1,   Gal-3?, 1,   ICAM-1↓, 4,   IFN-γ↓, 3,   IFN-γ↑, 5,   Igs↑, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 1,   IL10↑, 3,   IL12↓, 1,   IL12↑, 1,   IL18↑, 1,   IL1α↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↑, 3,   IL22↓, 1,   IL5↓, 1,   IL6↓, 18,   IL6↑, 1,   IL7↓, 1,   IL8↓, 3,   Imm↑, 30,   Imm⇅, 1,   Imm↝, 3,   INF-γ↝, 1,   Inflam↓, 20,   IP-10/CXCL-10↓, 1,   LIF↑, 1,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 5,   MCT1↓, 1,   MIP-1β↓, 1,   MIP-1β↑, 1,   MIP2↓, 1,   mPGES-1↓, 1,   Neut↑, 2,   NF-kB↓, 70,   NF-kB↑, 5,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 1,   NK cell↑, 12,   NLRP3↑, 1,   NOD1↓, 1,   PD-1↓, 2,   PD-L1↓, 6,   PD-L1↑, 1,   PDT+↓, 1,   PGE2↓, 15,   PGE2↑, 1,   PSA↓, 14,   RANTES↓, 1,   SOCS1↑, 1,   T-Cell↑, 3,   Th1 response↑, 1,   Th17↑, 1,   TLR4↓, 1,   TNF-α↓, 17,   TNF-α↑, 4,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,   Treg lymp↓, 1,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,   pH↓, 1,   pH↝, 2,   pH∅, 1,   e-pH↓, 1,   e-pH↑, 1,   i-pH↓, 1,   TAMS↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 1,   2/16-OHE1↝, 1,   AR↓, 12,   AR↝, 2,   COMT↑, 1,   CYP17A1↓, 1,   CYP19↓, 1,   DHT↓, 1,   ER-α36↓, 2,   ER-α36↝, 1,   ERα/ESR1↓, 1,   Estro↝, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARγ↑, 1,   testos↓, 1,   testos∅, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 31,   BioAv↑, 58,   BioAv↝, 24,   BioEnh?, 1,   BioEnh↑, 3,   chemoR↓, 1,   ChemoSen?, 1,   ChemoSen↓, 2,   ChemoSen↑, 145,   ChemoSen∅, 2,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP1B1↓, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   DDS↑, 6,   Dose?, 9,   Dose↓, 6,   Dose↑, 23,   Dose↝, 129,   Dose∅, 17,   eff?, 1,   eff↓, 51,   eff↑, 153,   eff↝, 25,   eff∅, 3,   GSTA1↓, 1,   GSTP1/GSTπ↓, 1,   GSTZ1↓, 1,   GSTZ1↝, 1,   Half-Life↓, 8,   Half-Life↑, 6,   Half-Life↝, 17,   MDR1↓, 4,   MRP1/ABCC1↓, 3,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 11,   P450↓, 2,   RadioS↑, 58,   selectivity?, 1,   selectivity↓, 2,   selectivity↑, 133,   selectivity↝, 1,   selectivity∅, 1,   Synergy?, 1,   Synergy↑, 110,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALAT↑, 1,   ALP↓, 1,   anemia↓, 1,   AR↓, 12,   AR↝, 2,   ascitic↓, 1,   AST↓, 2,   AST↑, 1,   B2M↓, 1,   BG↓, 5,   Bil∅, 1,   BloodF↑, 2,   BMD↑, 1,   BP↓, 1,   BRAF↑, 1,   BRCA1↓, 1,   BUN↓, 1,   CA125↓, 1,   CA125∅, 1,   CEA↓, 1,   creat↓, 1,   CRP↓, 2,   CTC↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 18,   EGFR↑, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 3,   Ferritin↓, 2,   Hcy/homoC↓, 1,   HER2/EBBR2↓, 8,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 18,   IL6↑, 1,   KeyT↑, 1,   KRAS↓, 1,   LDH↓, 4,   LDH↑, 2,   Maspin↑, 1,   Myc↓, 3,   NLR↓, 1,   PC↑, 1,   PD-L1↓, 6,   PD-L1↑, 1,   PSA↓, 14,   PSADT↓, 1,   PSADT↑, 2,   RBC↑, 1,   TG/TAG↓, 1,   TRIB3↑, 1,   Tumccf↓, 2,   VitD↑, 1,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiArt↑, 1,   AntiCan↓, 2,   AntiCan↑, 62,   AntiCan↝, 1,   antiCG↓, 1,   antiD↑, 1,   AntiDiabetic↑, 1,   antiNeop↑, 5,   AntiTum↓, 1,   AntiTum↑, 35,   AntiTum∅, 1,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 2,   cardioP↑, 10,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 41,   chemoP∅, 1,   chemoPv↑, 17,   ChemoSideEff↓, 6,   cognitive↑, 2,   CR↑, 4,   DCR↑, 2,   EFS↑, 1,   fatigue↓, 2,   FTO↑, 1,   GFR↑, 1,   hepatoP↓, 3,   hepatoP↑, 11,   hepatoP↝, 1,   hepatoP∅, 1,   LC↑, 3,   Mucositis↓, 2,   Nausea↓, 2,   Nausea∅, 1,   neuroP↓, 1,   neuroP↑, 10,   NP/CIPN↓, 2,   NP/CIPN↑, 2,   NP/CIPN↝, 1,   ORR↑, 2,   OS?, 2,   OS↑, 51,   OS⇅, 1,   OS↝, 1,   OS∅, 3,   Pain↓, 5,   PDE4↓, 1,   PFS↓, 1,   PFS↑, 5,   PFS∅, 1,   QoL↑, 13,   QoL↝, 1,   QoL∅, 3,   radioP↑, 10,   Remission↑, 9,   RenoP↓, 1,   RenoP↑, 6,   Risk↓, 27,   Risk↑, 2,   Risk∅, 2,   Sleep↑, 2,   Strength↑, 2,   toxicity?, 1,   toxicity↓, 189,   toxicity↑, 28,   toxicity⇅, 4,   toxicity↝, 92,   toxicity∅, 18,   TR↑, 1,   TumNum?, 1,   TumVol↓, 42,   TumVol∅, 1,   TumW↓, 23,   TumW∅, 1,   Vomit↓, 2,   Vomit∅, 1,   Weight↑, 3,   Weight∅, 3,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 5,   GutMicro↑, 4,   GutMicro↝, 1,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 8,  
Total Targets: 1000

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6,   antiOx↑, 117,   ARE↑, 3,   Bil↓, 3,   Bil↑, 1,   Catalase↓, 1,   Catalase↑, 38,   Copper↓, 1,   DPPH↓, 1,   Fenton↓, 3,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 24,   GPx1↑, 4,   GPx4↓, 1,   GPx4↑, 3,   GSH↓, 1,   GSH↑, 35,   GSR↓, 1,   GSR↑, 5,   GSSG∅, 1,   GSTs↓, 1,   GSTs↑, 7,   H2O2↓, 2,   H2O2∅, 1,   HDL↓, 2,   HDL↑, 4,   HNE↓, 1,   HO-1↓, 2,   HO-1↑, 18,   Iron↓, 2,   Iron↝, 1,   Iron∅, 1,   i-Iron↓, 1,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 39,   lipid-P↑, 1,   MDA↓, 30,   MDA↑, 1,   MPO↓, 3,   NADPH/NADP+↑, 1,   NOX4↓, 1,   NQO1↑, 6,   NQO1↝, 1,   NQO1∅, 1,   Nrf1↑, 1,   NRF2?, 1,   NRF2↓, 2,   NRF2↑, 38,   Prx↑, 1,   RNS↓, 2,   ROS↓, 134,   ROS↑, 10,   ROS⇅, 3,   ROS∅, 7,   mt-ROS?, 1,   selenoP↑, 7,   SOD↓, 3,   SOD↑, 48,   SOD1↑, 7,   SOD2↑, 6,   TAC↑, 8,   TBARS↓, 2,   TrxR1↑, 1,   uricA↓, 2,   VitC↑, 1,   xCT/SLC7A11↓, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 6,   IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

HSP60/HSPD1↓, 1,   Insulin↓, 2,   Insulin↑, 1,   mitResp↑, 3,   mtDam↓, 2,   OCR↓, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 5,   ACC↓, 1,   Acetyl-CoA↑, 1,   ACLY↓, 1,   ALAT↓, 18,   ALAT↑, 2,   ALAT∅, 3,   AMPK↓, 1,   AMPK↑, 9,   ATP↓, 3,   ATP↑, 9,   CRM↑, 2,   CYP51/14LDM↑, 1,   FASN↓, 1,   glucoNG↓, 1,   glucose↓, 7,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   GSK‐3β↝, 1,   p‑GSK‐3β↑, 1,   H2S↑, 1,   KeyT↑, 1,   LDL↓, 14,   lipidLev↓, 1,   NAD↓, 1,   NADPH↓, 2,   NADPH↑, 4,   NH3↓, 1,   NH3↑, 1,   PLA2↓, 1,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 7,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 10,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 6,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-2↑, 2,   Casp1↓, 2,   Casp3?, 1,   Casp3↓, 13,   Casp3↑, 1,   Casp9↓, 4,   Casp9↑, 1,   Cyt‑c↓, 2,   Fas↓, 1,   FasL↓, 1,   Ferroptosis↓, 2,   Ferroptosis↑, 1,   iNOS↓, 12,   p38↓, 2,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 5,   p‑Akt↓, 1,   p‑Akt↑, 2,   Akt2↓, 1,   CREB↑, 1,   ERK↓, 1,   IKKα↓, 1,   IκB?, 1,   JAK2↑, 1,   JNK↓, 4,   JNK↑, 2,   MAPK↓, 6,   MAPK↑, 2,   MAPK↝, 1,   p‑MAPK↓, 1,   mTOR↓, 4,   mTOR↑, 4,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 2,   PI3K↑, 4,   PKCδ?, 1,   PKCδ↑, 1,   PTEN↑, 1,   STAT↓, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 6,   ATF4↓, 2,   FOXO3↑, 1,   HDAC?, 1,   HDAC↓, 2,   HDAC3↓, 1,   HOTAIR↑, 1,   other?, 2,   other↓, 4,   other↑, 14,   other↝, 30,   PhotoS↑, 1,   SOX9↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 5,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 2,   NQO2↑, 1,   PERK↓, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 2,   CTSZ↓, 1,   LC3II↓, 1,   LC3II↑, 1,   MitoP↑, 2,   p62↑, 1,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 8,   DNAdam↑, 1,   DNArepair↑, 1,   P53↓, 3,   P53↑, 1,   PARP↓, 1,   PARP1↓, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   Ki-67↓, 1,   P21↓, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CHIP↑, 1,   Diff↑, 2,   GH↑, 2,   Ki-67↓, 1,   MSCs↑, 1,   neuroG↑, 2,   TumCG↓, 1,   TumCP↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 14,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 5,   Ca+2↑, 2,   Ca+2↝, 3,   Cartilage↑, 2,   COL2A1↑, 1,   EMT↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 4,   MMPs↓, 2,   ROCK1↓, 1,   Snail↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 1,   TGF-β↑, 2,   TIMP1↓, 2,   TumCI∅, 1,   TumCMig∅, 1,   Twist↑, 1,   Vim↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   angioG↝, 1,   E-sel↓, 1,   Hif1a↓, 3,   NO↓, 18,   NO↑, 1,   TXA2↓, 1,   VCAM-1↓, 5,   VEGF↓, 4,   VEGF↑, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 23,   BBB↝, 3,   EPR↑, 2,   GastroP↑, 4,   IBI↑, 4,   MMP↓, 1,   MMP↑, 4,   MMP∅, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 1,   TRPA1↑, 1,   TRPV3↑, 2,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

BALF-Infl↓, 1,   BALF-Lym↓, 1,   CD4+↑, 1,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 4,   COX1↑, 1,   COX2/PTGS2↓, 30,   COX2/PTGS2↑, 1,   CXCL15↓, 1,   Eos↓, 1,   HMGB1↓, 1,   ICAM-1↓, 4,   IFN-γ↓, 1,   IFN-γ↑, 2,   IL1↓, 2,   IL10↓, 6,   IL10↑, 3,   IL13↓, 1,   IL17↓, 3,   IL17↑, 1,   IL18↓, 1,   IL1α↓, 1,   IL1α∅, 1,   IL1β↓, 24,   IL1β↑, 1,   IL1β∅, 1,   IL2↓, 2,   IL22↓, 1,   IL4↓, 4,   IL4↑, 1,   IL5↓, 1,   IL5↑, 1,   IL6↓, 29,   IL6↑, 3,   IL8↓, 7,   IL8∅, 1,   Imm↓, 1,   Imm↑, 18,   Imm⇅, 1,   Inflam↓, 138,   Inflam↑, 4,   IP-10/CXCL-10↓, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 7,   MCP1/CCL2∅, 1,   MIP‑1α/CCL3?, 1,   MIP‑1α/CCL3↓, 1,   MyD88↓, 1,   NeuroI↓, 2,   Neut↓, 1,   Neut↑, 2,   NF-kB↓, 39,   NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 8,   NLRP3↑, 2,   PAF↓, 1,   PGE2↓, 17,   RANTES↓, 1,   TLR2↓, 2,   TLR4↓, 5,   TNF-α↓, 45,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

Astr↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5-AR↓, 2,   5HT↓, 1,   5HT↑, 5,   Ach↑, 2,   AChE↓, 22,   BChE↓, 6,   BDNF↓, 1,   BDNF↑, 14,   proBDNF↑, 1,   ChAT↑, 4,   DA↑, 1,   DHCR7↑, 1,   GABA↑, 2,   GABA↝, 1,   MAOA↓, 2,   MAOA↑, 1,   MAOB↓, 1,   NGF↑, 4,   TrkB↑, 2,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 1,   APP∅, 1,   Aβ↓, 29,   Aβ∅, 1,   Aβ42↓, 1,   BACE/β-secretase↓, 9,   QPCT/QC↓, 1,   tau↓, 7,   p‑tau↓, 5,   XO↓, 1,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AR↓, 1,   cortisol↓, 1,   CYP19↓, 1,   ER(estro)↓, 1,   PPARα↑, 2,   PPARγ↓, 3,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv?, 1,   BioAv↓, 42,   BioAv↑, 76,   BioAv⇅, 2,   BioAv↝, 29,   BioAv∅, 1,   BioEnh↑, 2,   CompStab↑, 2,   CYP2D6↓, 1,   CYP3A4↓, 1,   Dose?, 6,   Dose↓, 4,   Dose↑, 12,   Dose⇅, 1,   Dose↝, 91,   Dose∅, 2,   eff↓, 6,   eff↑, 43,   eff↝, 6,   GSTA1↓, 1,   Half-Life↓, 6,   Half-Life↑, 9,   Half-Life↝, 20,   Half-Life∅, 3,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 2,   P450↓, 2,   P450↑, 1,   selectivity↑, 1,   Synergy↑, 14,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 18,   ALAT↑, 2,   ALAT∅, 3,   ALB↑, 1,   ALP↓, 4,   AR↓, 1,   AST↓, 16,   AST↑, 2,   AST∅, 3,   Bil↓, 3,   Bil↑, 1,   BloodF↑, 8,   BMD↑, 3,   BP↓, 11,   BP↝, 1,   BP∅, 2,   BUN↑, 1,   creat↓, 3,   creat↑, 3,   CRP↓, 6,   HRV↑, 1,   hs-CRP↓, 1,   IL6↓, 29,   IL6↑, 3,   KeyT↑, 1,   LDH↓, 4,   NOS2↓, 1,   PV↓, 1,   rHR↓, 1,   TC↓, 4,   TG/TAG↓, 4,   UFR?, 1,   Urea↓, 1,   Urea↑, 1,   Verbal↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 1,   AirwayM↓, 1,   Analgesic↑, 4,   AntiAge↑, 8,   antiAll↑, 17,   AntiArt↑, 5,   AntiCan↑, 22,   antiCG↑, 1,   antiD↑, 2,   AntiDiabetic↑, 33,   AntiMyl↑, 1,   antiPs↑, 1,   AntiTum↑, 6,   ANXi↓, 2,   cardioP↑, 41,   CardioT↓, 1,   chemoP↑, 8,   chemoPv↑, 1,   cognitive↑, 46,   cognitive∅, 1,   cough?, 1,   DCR∅, 1,   diuretic↑, 4,   fatigue↓, 2,   hepatoP↓, 2,   hepatoP↑, 49,   IPSS↓, 1,   IPSS↝, 1,   Learn↑, 1,   memory↑, 30,   memory∅, 1,   Mood↑, 1,   motorD↑, 6,   Mucositis↓, 2,   neuroP↑, 84,   Obesity↓, 18,   ORR∅, 1,   OS↑, 5,   Pain↓, 15,   PDE4↓, 1,   PFS∅, 1,   QoL↑, 6,   radioP↑, 5,   RenoP↓, 1,   RenoP↑, 17,   Risk↓, 5,   RT↓, 2,   Sleep↑, 10,   SoreThr?, 1,   Strength↑, 5,   Stress↓, 5,   Stroke↓, 13,   Tinn↓, 2,   toxicity?, 6,   toxicity↓, 357,   toxicity↑, 38,   toxicity⇅, 2,   toxicity↝, 87,   toxicity∅, 71,   Weight↓, 3,   Weight↑, 1,   Weight↝, 1,   Weight∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 5,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 19,   AntiFungal↓, 1,   AntiFungal↑, 8,   AntiP↑, 3,   AntiViral↑, 15,   Bacteria↓, 45,   Diar↓, 2,   GutMicro↑, 24,   Inf↓, 2,   insect↑, 1,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 10,  
Total Targets: 527

Scientific Paper Hit Count for: toxicity, toxicity
31 Silver-NanoParticles
22 Selenium NanoParticles
18 chitosan
16 Magnetic Fields
14 Sulforaphane (mainly Broccoli)
13 Chemotherapy
13 Radiotherapy/Radiation
13 Dichloroacetate
12 5-Hydroxytryptophan
12 Selenite (Sodium)
10 3-bromopyruvate
10 Curcumin
10 EGCG (Epigallocatechin Gallate)
10 Hydrogen Gas
10 MCT, metronomic chemo
10 Phenylbutyrate
9 Cisplatin
9 Honokiol
9 Matrine
9 Magnetic Field Rotating
8 Copper and Cu NanoParticles
8 Metformin
8 Ginkgo biloba-EGb 761
8 Fenbendazole
8 itraconazole
8 Magnolol
7 Ashwagandha(Withaferin A)
7 Baicalein
7 Berberine
7 Carvacrol
7 Dandelion Root
7 Graviola
6 HydroxyCitric Acid
6 Apigenin (mainly Parsley)
6 borneol
6 Boron
6 D-limonene
6 Emodin
6 Eugenol
6 Germanium inorganic
6 phytic acid, Inositol hexakisphosphate
6 Resveratrol
6 mebendazole
6 Melatonin
6 Piperlongumine
6 Pterostilbene
6 Selenium
5 Auranofin
5 Allicin (mainly Garlic)
5 Artemisinin
5 Phenethyl isothiocyanate
5 Capsaicin
5 Diindolylmethane
5 Ellagic acid
5 Hyperthermia
5 Inositol
5 Lactoferrin/Talactoferrin
5 Luteolin
5 Phycocyanin
5 Shikonin
5 Urolithin
5 Vitamin K2
4 Gold NanoParticles
4 Alpha-Lipoic-Acid
4 doxorubicin
4 beta-glucans
4 Betulinic acid
4 α-Bisabolol / Chamomile oil
4 Celastrol
4 Chlorogenic acid
4 chaetocin
4 Chrysin
4 Cucurbitacin
4 salinomycin
4 Deguelin
4 Disulfiram
4 Folic Acid, Vit B9
4 Fucoidan
4 Gambogic Acid
4 Garcinol
4 Ginkgolic acids
4 Ginkgo biloba
4 Germanium Organic/Ge-132 / propagermanium (organogermanium)
4 Ginger/6-Shogaol/Gingerol
4 isoorientin
4 Kaempferol
4 L-Theanine
4 Licorice
4 Methylsulfonylmethane
4 Propolis -bee glue
4 Silymarin (Milk Thistle) silibinin
4 Thymoquinone
3 Vitamin C (Ascorbic Acid)
3 SonoDynamic Therapy UltraSound
3 Allyl isothiocyanate
3 Anti-oxidants
3 Atorvastatin
3 Baicalin
3 Beta-Caryophyllene
3 Bullatacin
3 Carnosine
3 Centella asiatica / Gotu kola → asiaticoside
3 Chlorophyllin
3 Cinnamon
3 Spirulina(Arthrospira/Limnospira)
3 Diclofenac
3 Docosahexaenoic Acid
3 diet FMD Fasting Mimicking Diet
3 Oxygen, Hyperbaric
3 Ivermectin
3 Flaxseed/Linseed
3 Gallic acid
3 Geldanamycin
3 Genistein (soy isoflavone)
3 Ginkgetin
3 Gossypol/AT-101
3 HydroxyTyrosol
3 Indole-3-carbinol
3 Isoliquiritigenin
3 Licochalcone A
3 low dose naltrexone
3 Linalool
3 Modified Citrus Pectin
3 Mangiferin
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Bicarbonate(Sodium)
3 Niclosamide (Niclocide)
3 Marjoram (Origanum majorana)
3 Quercetin
3 Rosmarinic acid
3 Sulfasalazine
2 Açaí, Euterpe oleracea
2 Astragalus
2 Zinc
2 Paclitaxel/Taxol
2 Arsenic trioxide
2 Aloe anthraquinones
2 Berbamine
2 Benzyl isothiocyanate
2 brusatol
2 Bacopa monnieri
2 Boswellia (frankincense)
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Thymol-Thymus vulgaris
2 carboplatin
2 Hydroxycinnamic-acid
2 Coenzyme Q10
2 Vitamin E
2 CUSP9
2 Docetaxel
2 Lemongrass Extract/Citral
2 immunotherapy
2 Echinacea
2 Estragole
2 Fennel Oil/Foeniculum vulgare
2 Evodiamine
2 Ferulic acid
2 Flickering Light Stimulation
2 Formononetin
2 SDG/lignans
2 Flaxseed Oil
2 Vitamin D3
2 Shilajit/Fulvic Acid
2 Gamma-aminobutyric acid
2 Germanium-Spirogermanium
2 Germacranolide sesquiterpene lactone
2 Hibiscus sabdariffa
2 Hyperoside
2 isoflavones
2 isoquercitrin
2 Isothiocyanates
2 Laetrile B17 Amygdalin
2 Lapatinib
2 Lycopene
2 MCT oil
2 Moringa oleifera
2 Morin
2 Mushroom Chaga, Inonotus obliquus
2 Mushroom Maitake
2 Patchouli Oil (Pogostemon cablin)
2 Propyl gallate
2 Piperine
2 Psoralidin
2 Ramucirumab (CYRAMZA)
2 EMF
2 Terpinen-4-ol / Tea Tree Oil
2 tetrathiomolybdate
2 Whole Body Vibration
1 1,8-Cineole
1 Resiquimod
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 5-Aminolevulinic acid
1 Aspirin
1 Ascorbyl Palmitate
1 Astaxanthin
1 Dipyridamole
1 Biochanin A
1 Bufalin/Huachansu
1 Brucea javanica
1 Bromelain
1 Beetroot
1 Bruteridin(bergamot juice)
1 Butyrate
1 Carnosic acid
1 Catechins
1 Cat’s Claw
1 Camu camu
1 Celecoxib
1 Chocolate
1 Cichoric acid / Chicoric acid
1 Citric Acid
1 Carica papaya leaf extract
1 Camptothecin
1 irinotecan
1 Cranberry
1 Crocetin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Black phosphorus
1 chemodynamic therapy
1 Chlorella (Chlorella vulgaris)
1 Cynaropicrin
1 Cysteamine
1 diet Fermented Foods
1 diet Ketogenic
1 diet Methionine-Restricted Diet
1 Ormeloxifene (Centchroman)
1 Protocatechuic acid
1 ferumoxytol
1 Fisetin
1 Auditory Gamma Stimulation / 40 Hz Auditory Stimulation
1 Ginkgolide B
1 Grapeseed extract
1 hydroxychloroquine
1 Isobavachalcone
1 imatinib
1 Inulin Prebiotic
1 Isovitexin
1 Juglone
1 L-ornithine
1 Trastuzumab
1 Lapachol
1 Lasiodin
1 capecitabine
1 Methyl Jasmonate
1 Methyl salicylate / Sweet Birch oil
1 Magnesium
1 magnetic nanoparticles
1 Mucuna pruriens/Velvet Bean
1 Mistletoe/Viscum album Extracts
1 nicotinamide adenine dinucleotide
1 Naringin
1 Nasturtium, Indian Cress
1 Oleuropein
1 Peppermint
1 5-fluorouracil
1 sericin
1 Purple Corn / Purple Maize
1 Photodynamic Therapy
1 Sanguinarine
1 Plumbagin
1 probiotics
1 Bifidobacterium
1 Pumpkin Seed Oil / Cucurbita pepo
1 Tamsulosin
1 benzo(a)pyrene
1 Rauwolfia serpentina/Indian Snakeroot
1 Rutin
1 buckwheat sprouts
1 α-Santalol/Sandalwood oil
1 Date Fruit Extract
1 Taurine
1 Aflavin-3,3′-digallate
1 Turmerones
1 Vitamin B1/Thiamine
1 Vitexin
1 Wogonin
1 Xylitol
1 Zerumbone
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1025  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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