neuroP Cancer Research Results

neuroP, neuroprotective: Click to Expand ⟱
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Neuroprotective refers to the ability of a substance, intervention, or strategy to preserve the structure and function of nerve cells (neurons) against injury or degeneration.
-While cancer and neurodegenerative processes might seem distinct, there is significant overlap in terms of treatment-related neurotoxicity, shared molecular mechanisms, and the potential for therapies that provide neuroprotection during cancer treatment.
Scientific Papers found: Click to Expand⟱
3600- PI,    Intranasal piperine-loaded chitosan nanoparticles as brain-targeted therapy in Alzheimer's disease: optimization, biological efficacy, and potential toxicity
- in-vivo, AD, NA
*neuroP↑,
2999- PL,    Piperlongumine alleviates corneal allograft rejection via suppressing angiogenesis and inflammation
- in-vivo, Nor, HUVECs
*Inflam↓, *angioG↓, *Hif1a↓, *VEGF↓, *ICAM-1↓, *VCAM-1↓, *neuroP↑,
2944- PL,    Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells
- in-vitro, Thyroid, IHH4 - in-vitro, Thyroid, 8505C - in-vivo, NA, NA
ROS↑, selectivity↑, tumCV↓, TumCCA↑, Apoptosis↑, ERK↑, Akt↓, mTOR↓, neuroP↑, Bcl-2↓, Casp3↑, PARP↑, JNK↑, *toxicity↓, eff↓, TumW↓,
2950- PL,    Overview of piperlongumine analogues and their therapeutic potential
- Review, Var, NA
AntiAg↑, neuroP↑, Inflam↓, NO↓, PGE2↓, MMP3↓, MMP13↓, TumCMig↓, TumCI↓, p38↑, JNK↑, NF-kB↑, ROS↑, FOXM1↓, TrxR1↓, GSH↓, Trx↓, cMyc↓, Casp3↑, Bcl-2↓, Mcl-1↓, STAT3↓, AR↓, DNAdam↑,
2963- PL,    Piperlongumine activates Sirtuin1 and improves cognitive function in a murine model of Alzheimer’s disease
- in-vitro, AD, HEK293
*SIRT1↑, *cognitive↑, *Aβ↓, *Inflam↓, *neuroP↑, memory↑, Dose↓, NAD↑,
2960- PL,    Synthesis of Piperlongumine Analogues and Discovery of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators as Potential Neuroprotective Agents
- Analysis, Nor, NA
NRF2↑, neuroP↑,
3917- PS,    Phosphatidylserine, inflammation, and central nervous system diseases
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *neuroP↑, *cognitive↑, *Choline↑, *IL1β↓, *IL6↓, *TNF-α↓, *Ach↑, *eff↑, *eff↑, *BioEnh↑, other↑,
3910- PS,    Neuroprotective Effect of Bean Phosphatidylserine on TMT-Induced Memory Deficits in a Rat Model
- in-vivo, AD, NA
*memory↑, *neuroP↑, *GlucoseCon↑, *ChAT↑,
4968- PSO,    Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer
- in-vitro, Cerv, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiDiabetic↑, *Bacteria↓, AntiTum↑, CSCs↓, ROS↑, TumAuto↑, Apoptosis↑, ChemoSen↑, RadioS↑, BioAv↓, *cardioP↑, *ROS↓, *LDH↓, TumCP↓, TRAIL⇅, TumCMig↓, EMT↓, NF-kB↓, P53↑, Casp3↑, NOTCH↓, CSCs↓, angioG↓, VEGF↓, Ki-67↓, CD31↓, TRAILR↑, MMP↓, BioAv↓, BioAv↑,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
3929- PTS,    New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects
- Review, Var, NA - Review, Arthritis, NA
*NRF2↑, *BioAv↑, *ROS↓, *Inflam↓, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *hepatoP↑, *neuroP↑, *iNOS↓, *COX2↓, TumMeta↓, SOD2↓, ROS↑, TumCI↓, TumCG↓, HDAC1↓, PTEN↑, BP↓, *GutMicro↑,
3924- PTS,    Effect of resveratrol and pterostilbene on aging and longevity
- Review, AD, NA - Review, Stroke, NA
*antiOx↓, *ROS↑, *SOD↑, *GSH↑, *NRF2↑, *MDA↓, *HNE↓, *Inflam↓, *MAPK↓, *IL6↓, *TNF-α↓, *HO-1↑, *cardioP↑, *neuroP↑, *CRM↑, *NLRP3↓,
3922- PTS,    Pterostilbene attenuates amyloid-β induced neurotoxicity with regulating PDE4A-CREB-BDNF pathway
- in-vivo, AD, NA
*BioAv↑, *BBB↑, *memory↑, *p‑CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
4162- QC,    Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway
- in-vivo, Stroke, NA
*neuroP↑, *BDNF↑, *TrkB↑, *p‑Akt↑,
3607- QC,    Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
- Review, AD, NA - Review, Park, NA
*neuroP↑, *NRF2↑, *PONs↑, *antiOx↑, *Inflam↓, *SIRT1↑, *eff↑, *ROS↓, *cognitive↑, *eff↑, *lipid-P↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑,
3601- QC,    Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid
- Review, Var, NA - Review, AD, NA
*Inflam↓, *cardioP↑, AntiCan↑, AntiTum↑, *neuroP↑, *cognitive↑, *ROS↓, *BP↓, *LDL↓,
3602- QC,    The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice
- in-vivo, AD, NA
*BACE↓, *cognitive↑, *ROS↓, *lipid-P↓, *iNOS↓, *COX2↓, *BBB↑, *neuroP↑, *other↓, *memory↑,
3603- QC,    Mechanism of quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus
- Review, AD, NA - Review, Diabetic, NA
*MAPK↓, *neuroP↑, *ROS↓, *Akt↓, *PI3K↓, *IL6↓, *TNF-α↓, *VEGF↓, *EGFR↓, *Casp3↓, *Bcl-2↓, *IL1β↓,
3604- QC,    Quercetin enrich diet during the early-middle not middle-late stage of alzheimer’s disease ameliorates cognitive dysfunction
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *neuroP↑, *BACE↓, *p‑SMAD2↓, *p‑STAT3↓, *SPARC↓,
3380- QC,    Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases
- Review, Var, NA - Review, Park, NA - Review, AD, NA
JAK↓, STAT↓, Inflam↓, NO↓, COX2↓, CRP↓, selectivity↑, *neuroP↑, STAT3↓, cycD1/CCND1↓, MMP2↓, STAT4↓, JAK2↓, TumCP↓, Diff↓, *eff↑, *IL6↓, *TNF-α↓, *IL1β↓, *Aβ↓,
3353- QC,    Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
- in-vitro, Oral, KON - in-vitro, Nor, MRC-5
tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,
3351- QC,    Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and Aβ Aggregates in Hippocampal Neurons: the Role of Mitochondria
- Review, AD, NA
*ROS↓, *neuroP↑,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *eff↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *lipid-P↓, *antiOx↑, *Aβ↓, *Inflam↓, *BBB↝, *NF-kB↓, *iNOS↓, *memory↑, *cognitive↑, *AChE↓, *MMP↑, *ROS↓, *ATP↑, *AMPK↑, *NADPH↓, *p‑tau↓,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *GSH↑, *ROS↓, *Dose↑, *NADPH↓, *AMP↓, *NF-kB↓, *p38↑, *MAPK↑, *SOD↑, *MDA↓, *iNOS↓, *Catalase↑, *PI3K↑, *Akt↑, *lipid-P↓, *memory↑, *radioP↑, *neuroP↑, *MDA↓,
3374- QC,    Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis
- Review, Oral, NA - Review, AD, NA
α-SMA↓, α-SMA↑, TumCP↓, tumCV↓, TumVol↓, TumCI↓, TumMeta↓, TumCMig↓, ROS↑, Apoptosis↑, BioAv↓, *neuroP↑, *antiOx↑, *Inflam↓, *Aβ↓, *cardioP↑, MMP↓, Cyt‑c↑, MMP2↓, MMP9↓, EMT↓, MMPs↓, Twist↓, Slug↓, Ca+2↑, AIF↑, Endon↑, P-gp↓, LDH↑, HK2↓, PKA↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, GRP78/BiP↑, Casp12↑, CHOP↑,
3367- QC,    Targeting Nrf2 signaling pathway by quercetin in the prevention and treatment of neurological disorders: An overview and update on new developments
- Review, Stroke, NA - Review, AD, NA
*NRF2↑, *neuroP↑, *motorD↑, *Inflam↓, *cognitive↑,
4297- QC,    Quercetin attenuates tau hyperphosphorylation and improves cognitive disorder via suppression of ER stress in a manner dependent on AMPK pathway
- in-vitro, AD, SH-SY5Y
*AMPK↑, *IRE1↓, *p‑PERK↓, *p‑tau↓, *cognitive↑, *antiOx↑, *ER Stress↓, *Inflam↓, *neuroP↑, *TXNIP↓, *NLRP3↓,
6417- RES,  CUR,    Curcumin and Resveratrol Synergy: A Multi-Target Strategy Against Neurodegenerative Disease Pathology
- Review, AD, NA
*neuroP↑, *NRF2↝, *ARE↝, *NF-kB↓, *Aβ↓, *ROS↓, *Inflam↓, *BioAv↓,
6423- RES,    Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity
- vitro+vivo, Park, NA
*neuroP↑, *FIS1↓, *OPA1↓, *MFN2↓, *PGC-1α↑, *ROS↓, *ATP↑, *motorD↑,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, eff↑, HK2↓, ROS↑, MMP↓,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
2567- RES,    Neuroprotective Effects of Resveratrol in Ischemic Brain Injury
- Review, Stroke, NA
*eff↑, *neuroP↑, *antiOx↑, *Inflam↓, *cardioP↑, *AntiAg↑,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, eff↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3099- RES,    Resveratrol and cognitive decline: a clinician perspective
- Review, Nor, NA - NA, AD, NA
*antiOx↑, *ROS↓, *cognitive↑, *neuroP↑, *SIRT1↑, *AMPK↑, *GPx↑, *HO-1↑, *GSK‐3β↑, *COX2↓, *PGE2↓, *NF-kB↓, *NO↓, *Casp3↓, *MMP3↓, *MMP9↓, *MMP↑, *GSH↑, *other↑, *BioAv↑, *memory↑, *GlutMet↑, *BioAv↓, *Half-Life↓, *toxicity∅,
3100- RES,    Neuroprotective effects of resveratrol in Alzheimer disease pathology
- Review, AD, NA
*neuroP↑, *BioAv↓, *Half-Life↓, *BioAv↑, *BBB↑, *NRF2↑, *BioAv↓, *BioAv↑, *SIRT1↑, *cognitive↑, *lipid-P↓, *HO-1↑, *SOD↑, *GSH↑, *GPx↑, *G6PD↑, *PPARγ↑, *AMPK↑, *Aβ↓,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
4153- RES,    Effect of oral resveratrol on the BDNF gene expression in the hippocampus of the rat brain
- in-vivo, AD, NA
*neuroP↑, *BDNF↑,
4154- RES,    Resveratrol improves postnatal hippocampal neurogenesis and brain derived neurotrophic factor in prenatally stressed rats
- in-vivo, AD, NA
*neuroP↑, *BDNF↑,
3612- RES,    Resveratrol in Alzheimer's disease: a review of pathophysiology and therapeutic potential
- Review, AD, NA
*other↑, *Aβ↓, *Inflam↓, *NF-kB↓, *neuroP↑, *HO-1↑, *lipid-P↓, *COX2↓, *AMPK↑, *Catalase↑, *SOD↑, *GSR↑, *ROS↓, *MMP9↓, *cognitive↑, *SIRT1↑, *IL1β↓, *IL6↓,
3614- RES,    Resveratrol--a boon for treating Alzheimer's disease?
- Review, AD, NA
*SIRT1↑, *neuroP↑,
3858- RES,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
*neuroP↑, *antiOx↑, *LDL↓, *ADAM10↑,
4289- RES,    Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells
- in-vitro, AD, NA
*antiOx↑, *p‑tau↓, *GSK‐3β↓, *CaMKII ↓, *PP2A↑, *neuroP↑,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE↓,
4284- RES,    Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
- in-vitro, AD, HEK293 - NA, Stroke, NA - in-vivo, AD, NA
*p‑tau↓, *PP2A↑, *neuroP↑, *antiOx↑, COX2↓, *AntiAg↑, *SIRT1↑, *AMPK↑, *Acetyl-CoA↓, *FAO↑, *ADAM10↑, *BACE↓, *Aβ↓, *memory↑, *Inflam↓, *ROS↓,
3731- RF,    Electromagnetic field treatment protects against and reverses cognitive impairment in Alzheimer's disease mice
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *neuroP↑, *memory↑,
3615- RosA,    Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer's Disease, Parkinson's Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome
- Review, AD, NA - Review, Park, NA
*NLRP3↓, *Inflam↓, *neuroP↑, *NRF2↑, *TNF-α↓, *NF-kB↓, *HO-1↑, *ROS↓,

Showing Research Papers: 401 to 450 of 583
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 583

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GPx↑, 1,   GSH↓, 1,   GSH↑, 1,   H2O2↑, 1,   HO-1↑, 2,   lipid-P↓, 1,   NRF2↑, 2,   ROS↓, 1,   ROS↑, 9,   ROS↝, 1,   mt-ROS↑, 1,   SOD↑, 1,   SOD2↓, 1,   SOD2↑, 1,   Trx↓, 1,   TrxR1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 1,   MMP↓, 7,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cMyc↓, 4,   GlucoseCon↓, 2,   GlutMet↓, 1,   Glycolysis↓, 2,   HK2↓, 3,   lactateProd↓, 2,   LDH↑, 1,   NAD↑, 1,   NADPH↓, 1,   PFK↓, 1,   POLD1↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,   SIRT2↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 6,   p‑Akt↓, 1,   Apoptosis↑, 7,   BAX↓, 1,   BAX↑, 3,   Bcl-2↓, 4,   Casp12↑, 1,   Casp3↑, 5,   Casp9↑, 1,   CK2↓, 1,   Cyt‑c↑, 4,   Diablo↑, 1,   Endon↑, 1,   HGF/c-Met↓, 1,   JNK↑, 2,   MAPK↓, 1,   Mcl-1↓, 1,   MDM2↓, 1,   p38↓, 1,   p38↑, 1,   survivin↓, 1,   TRAIL⇅, 1,   TRAILR↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↑, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   p62↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↑, 2,   PARP↑, 1,   cl‑PARP↑, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   P21↓, 1,   P21↑, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CD24↓, 1,   CD44↓, 2,   CSCs↓, 4,   Diff↓, 1,   EMT↓, 4,   ERK↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   FOXM1↓, 1,   FOXO4↓, 1,   HDAC1↓, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   mTOR↓, 2,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   PI3K↓, 3,   PTEN↑, 4,   RAS↓, 1,   Shh↓, 1,   STAT↓, 1,   STAT3↓, 3,   STAT4↓, 1,   TCF↓, 1,   TOP2↓, 2,   TumCG↓, 2,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↑, 2,   CD31↓, 1,   E-cadherin↑, 2,   Fibronectin↓, 1,   Ki-67↓, 3,   KRAS↓, 1,   MALAT1↓, 1,   MMP13↓, 1,   MMP2↓, 5,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 4,   MMPs↓, 3,   PKA↓, 1,   PKCδ↓, 1,   Slug↓, 3,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↑, 2,   TIMP2↑, 1,   TumCI↓, 6,   TumCMig↓, 5,   TumCP↓, 7,   TumMeta↓, 6,   Twist↓, 2,   Vim?, 1,   Vim↓, 1,   Zeb1↓, 1,   α-SMA↓, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   EGFR↓, 1,   Hif1a↓, 3,   NO↓, 2,   VEGF↓, 5,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 3,   CRP↓, 2,   CXCR4↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 2,   JAK↓, 1,   JAK2↓, 1,   NF-kB↓, 4,   NF-kB↑, 1,   PD-1↓, 1,   PGE2↓, 1,   Th1 response↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 1,   BioEnh?, 1,   ChemoSen↑, 5,   ChemoSen⇅, 1,   Dose↓, 1,   eff↓, 1,   eff↑, 11,   MDR1↓, 2,   P450↓, 1,   RadioS↑, 3,   selectivity↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   BP↓, 1,   CRP↓, 2,   EGFR↓, 1,   FOXM1↓, 1,   IL6↓, 1,   Ki-67↓, 3,   KRAS↓, 1,   LDH↑, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 2,   cardioP↑, 1,   memory↑, 1,   neuroP↑, 3,   TumVol↓, 1,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 195

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 19,   ARE↝, 1,   Catalase↑, 6,   GPx↑, 7,   GSH↑, 10,   GSR↑, 2,   H2O2↓, 3,   HNE↓, 1,   HO-1↑, 12,   HO-1⇅, 1,   Keap1↓, 2,   lipid-P↓, 10,   mt-lipid-P↓, 1,   MDA↓, 6,   Mets↝, 1,   MFN2↓, 1,   MPO↓, 1,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 13,   NRF2↝, 1,   OPA1↓, 1,   ROS↓, 24,   ROS↑, 2,   SOD↑, 10,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 3,   FIS1↓, 1,   MMP↑, 3,   PGC-1α↓, 1,   PGC-1α↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Acetyl-CoA↓, 1,   AMP↓, 1,   AMPK↑, 8,   CREB↑, 1,   p‑CREB↑, 2,   CRM↑, 1,   FAO↑, 1,   G6PD↑, 1,   GlucoseCon↑, 1,   GlutMet↑, 1,   LDH↓, 1,   LDL↓, 2,   NADH:NAD↑, 1,   NADPH↓, 2,   PONs↑, 1,   PPARγ↑, 2,   SIRT1↑, 11,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↑, 1,   Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp3↓, 2,   Cyt‑c∅, 1,   iNOS↓, 6,   MAPK↓, 3,   MAPK↑, 1,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other↓, 1,   other↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSP70/HSPA5↝, 1,   IRE1↓, 1,   p‑PERK↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Choline↑, 1,   ERK↑, 1,   FOXO↑, 1,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   IGF-1↑, 1,   PI3K↓, 1,   PI3K↑, 2,   p‑STAT3↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 1,   Ca+2↓, 1,   MMP3↓, 1,   MMP9↓, 4,   PKA↑, 1,   PKCδ↓, 1,   p‑SMAD2↓, 1,   SPARC↓, 1,   TXNIP↓, 1,   VCAM-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   EGFR↓, 1,   Hif1a↓, 1,   NO↓, 1,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 3,   BBB↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 8,   CRP↓, 1,   ICAM-1↓, 2,   IFN-γ↑, 1,   IKKα↓, 1,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 8,   IL6↓, 7,   Inflam↓, 25,   MCP1↓, 1,   NF-kB↓, 10,   p65↓, 1,   PGE2↓, 1,   TLR4↓, 1,   TLR4↑, 1,   TNF-α↓, 9,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   ADAM10↑, 2,   BChE↓, 1,   BDNF↑, 5,   ChAT↑, 1,   GABA↑, 1,   PSD95↑, 1,   tau↓, 1,   p‑tau↓, 5,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 13,   BACE↓, 4,   NLRP3↓, 5,   PP2A↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 12,   BioAv↝, 1,   BioEnh↑, 1,   Dose↑, 1,   Dose↝, 1,   eff↑, 10,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 4,   CRP↓, 1,   EGFR↓, 1,   GutMicro↑, 1,   IL6↓, 7,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 12,   cognitive↑, 14,   hepatoP↑, 4,   memory↑, 13,   motorD↑, 3,   neuroP↑, 47,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 2,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 166

Scientific Paper Hit Count for: neuroP, neuroprotective
22 Resveratrol
21 Thymoquinone
20 Alpha-Lipoic-Acid
18 Magnetic Fields
18 Quercetin
16 Silymarin (Milk Thistle) silibinin
15 Urolithin
14 Curcumin
14 Chlorogenic acid
14 Hydrogen Gas
12 Rosmarinic acid
11 Baicalein
11 Lycopene
10 Ashwagandha(Withaferin A)
10 Carvacrol
10 Crocetin
9 Berberine
9 Bacopa monnieri
9 Chrysin
9 Ferulic acid
9 Honokiol
8 Moringa oleifera
8 Sulforaphane (mainly Broccoli)
7 Allicin (mainly Garlic)
7 Centella asiatica / Gotu kola → asiaticoside
7 Piperine
7 EGCG (Epigallocatechin Gallate)
7 Huperzine A/Huperzia serrata
7 Taurine
6 Apigenin (mainly Parsley)
6 Selenium NanoParticles
6 Cysteamine
6 Eugenol
6 Fisetin
6 Ginseng
6 Mushroom Lion’s Mane
6 Phenylbutyrate
6 Silicic Acid
5 Astaxanthin
5 Beta-Caryophyllene
5 Vitamin C (Ascorbic Acid)
5 α-Bisabolol / Chamomile oil
5 Capsaicin
5 Luteolin
5 Piperlongumine
5 Shankhpushpi
5 Shikonin
5 Vitamin E
5 Vitamin B5,Pantothenic Acid
4 Boron
4 Boswellia (frankincense)
4 Carnosic acid
4 Carnosine
4 Propolis -bee glue
4 Folic Acid, Vit B9
4 Shilajit/Fulvic Acid
4 Melatonin
4 Magnetic Field Rotating
4 Pterostilbene
4 Vitamin B12
3 Anthocyanins
3 Artemisinin
3 Biochanin A
3 Betulinic acid
3 Vitamin B6,pyridoxine
3 Caffeic acid
3 Exercise
3 Celastrol
3 Cichoric acid / Chicoric acid
3 Cinnamon
3 Coenzyme Q10
3 diet Short Term Fasting
3 Methylene blue
3 Magnolol
3 nicotinamide adenine dinucleotide
3 Rutin
3 Selenite (Sodium)
3 Ursolic acid
2 1,8-Cineole
2 Anethole/trans-Anethole
2 Baicalin
2 beta-carotene(VitA)
2 borneol
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Chlorophyllin
2 Choline
2 Hydroxycinnamic-acid
2 Calorie Restriction Mimetics
2 Spermidine
2 Cucurbitacin
2 Metformin
2 D-limonene
2 Dandelion Root
2 Ellagic acid
2 Emodin
2 Ginkgo biloba
2 Geraniol
2 EMF
2 Naringin
2 Phosphatidylserine
2 Chemotherapy
2 Vitamin D3
2 Vitamin K2
1 Astragalus
1 alpha Linolenic acid
1 Aluminum
1 Fennel Oil/Foeniculum vulgare
1 doxorubicin
1 xanthohumol
1 Butyrate
1 Paclitaxel
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chitosan
1 Selenium
1 Carica papaya leaf extract
1 Aspirin
1 Carvone
1 Silver-NanoParticles
1 Dichloroacetate
1 Bortezomib
1 Diclofenac
1 Date Fruit Extract
1 diet Methionine-Restricted Diet
1 diet FMD Fasting Mimicking Diet
1 Eurycomanone
1 Germacranolide
1 MCToil
1 Methylsulfonylmethane
1 Nimbolide
1 Psoralidin
1 Salvia officinalis
1 Aromatherapy
1 Sesame seeds and Oil
1 Anti-oxidants
1 Aflavin-3,3′-digallate
1 Turmerones
1 Vitamin A, Retinoic Acid
1 Vitamin B1/Thiamine
1 Vitamin B3,Niacin
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1105  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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