selectivity Cancer Research Results

selectivity, selectivity: Click to Expand ⟱
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The selectivity of cancer products (such as chemotherapeutic agents, targeted therapies, immunotherapies, and novel cancer drugs) refers to their ability to affect cancer cells preferentially over normal, healthy cells. High selectivity is important because it can lead to better patient outcomes by reducing side effects and minimizing damage to normal tissues.

Achieving high selectivity in cancer treatment is crucial for improving patient outcomes. It relies on pinpointing molecular differences between cancerous and normal cells, designing drugs or delivery systems that exploit these differences, and overcoming intrinsic challenges like tumor heterogeneity and resistance

Factors that affect selectivity:
1. Ability of Cancer cells to preferentially absorb a product/drug
-EPR-enhanced permeability and retention of cancer cells
-nanoparticle formations/carriers may target cancer cells over normal cells
-Liposomal formations. Also negatively/positively charged affects absorbtion

2. Product/drug effect may be different for normal vs cancer cells
- hypoxia
- transition metal content levels (iron/copper) change probability of fenton reaction.
- pH levels
- antiOxidant levels and defense levels

3. Bio-availability
Scientific Papers found: Click to Expand⟱
8114- LA,    Normal and tumour cervical cells respond differently to vaginal lactobacilli, independent of pH and lactate
- in-vitro, Cerv, HeLa
AntiTum↑, TumCD↑, selectivity↓,
8150- lamb,    Reactive oxygen species dependent phosphorylation of the liver kinase B1/AMP activated protein kinase/ acetyl-CoA carboxylase signaling is critically involved in apoptotic effect of lambertianic acid in hepatocellular carcinoma cells
- in-vitro, HCC, HepG2 - in-vitro, HCC, SK-HEP-1
lipidLev↓, TumCCA↑, cl‑Casp3↑, cl‑PARP↑, AMPK↑, Akt↓, mTOR↓, Bcl-2↓, Bcl-xL↓, COX2/PTGS2↓, ROS↑, eff↓, p‑STK11/LKB1↑, p‑ACC↑, *Obesity↓, *Stress↓, *antiAll↑, tumCV↓, selectivity↑, TumCP↓, *antiAll↑,
8249- LCA,    Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells
- in-vitro, NSCLC, NA
tumCV↓, LDH↑, Apoptosis↑, selectivity↑, LC3II↑, TumAuto↑, ER Stress↑, CHOP/DDIT3↑, chemoP↑, RenoP↑, cl‑PARP↑, cl‑Casp7↑, cl‑Casp3↑,
8248- LCA,    Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2/M Cell Cycle Arrest and ER Stress
- in-vitro, NSCLC, A549 - in-vitro, Lung, H460
tumCV↓, TumCG↓, TumCCA↑, MDM2↓, CycB/CCNB1↓, cDC2↓, CDC25↓, Casp3↑, PARP↑, ER Stress↑, p‑eIF2α↑, ATF4↑, TumCP↓, selectivity↑, Bcl-xL↓, Bcl-2↓,
8238- LCA,    Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6
- in-vitro, BC, MCF7 - in-vivo, NA, MCF10
PRMT6↓, EstroRS/ERS↓, selectivity?, P53↑, TumCCA↑, Apoptosis↑,
8206- LCA,    Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways
- in-vivo, GC, BGC-823
ROS?, Casp3↑, cl‑PARP↑, eff↓, ERK↑, JNK↑, MAPK↑, AntiP↑, AntiTum↑, TumCP↓, selectivity↑, GSH/GSSG↓, MDA↑, lipid-P↑, PI3K↓, Akt↓,
8233- LCA,    Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer
- in-vitro, Lung, NA
TumCP↓, selectivity↑, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, BAX↑, PARP1↑, Casp3↑, Bcl-2↓, MAPK↓, FBXO5/EMI1↓, TumVol↓, TumW↓, toxicity↓,
8404- LDN,  Rad,    Chemotherapeutic effects of luteolin on radio-sensitivity enhancement and interleukin-6/signal transducer and activator of transcription 3 signaling repression of oral cancer stem cells
- in-vitro, Oral, NA
TumCP?, ALDH1A1↓, CD44↓, selectivity↑, RadioS↑,
8287- LE,    New insights into the antioxidant and apoptotic potential of Glycyrrhiza glabra L. during hydrogen peroxide mediated oxidative stress: An in vitro and in silico evaluation
- in-vitro, Nor, NA
*antiOx↑, *MDA↓, *lipid-P↓, *SOD?, *Catalase↑, *GSTs↑, *GPx↑, *GR↑, selectivity↑, tumCV↓, Casp8↑, Casp3↑, Bcl-2↓,
8279- LE,    18β-Glycyrrhetinic Acid Has Anti-Cancer Effects via Inducing Apoptosis and G2/M Cell Cycle Arrest, and Inhibiting Migration of A549 Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H23 - in-vitro, Lung, H460
tumCV↓, selectivity↑, Apoptosis↑, ROS↑, TumCCA↑, TumCMig↓, TumCP↓, MMP↓, BAD↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, p‑STAT3↓, NF-kB↓,
8130- LF,    Lactoferrin targeting INTL1 receptor inhibits hepatocellular carcinoma progression via apoptosis and cell cycle signaling pathways
- in-vitro, HCC, HepG2 - in-vitro, HCC, HepG3 - in-vitro, HCC, SK-HEP-1
Iron↓, TumCP↓, selectivity↑, TumCCA↑, p‑MAPK↑, JNK↑, Apoptosis↑,
8131- LF,    Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma
- in-vitro, OS, HSC2 - in-vitro, OS, HSC3 - in-vitro, OS, HSC4 - in-vitro, Nor, RT7
P53↑, Akt↓, SOCS-3↑, mTOR↓, JAK↓, STAT3↓, selectivity↑, TumCP↓, Iron↓, TumCCA↑,
8132- LF,    Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase
- in-vitro, BC, HS587T - in-vitro, BC, MDA-MB-231 - in-vitro, BC, T47D - in-vitro, BC, MCF10
Iron↓, AntiCan↑, Apoptosis↑, selectivity↑, ECAR↓, i-pH↑, ATPase↓,
8134- LF,    Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways
- in-vitro, CRC, HT-29
Iron↓, Apoptosis↑, selectivity↑, Casp8↑, P53↑, P21↑,
8193- LGE,    Targets and pathways involved in the antitumor activity of citral and its stereo-isomers
- Review, Var, NA
TumCP↓, Apoptosis↑, ROS↑, DNAdam↑, MARK4↓, ALDH1A3↓, CSCs↓, chemoR↓, BioAv↓, selectivity↝,
8191- LGE,    Lemongrass (Cymbopogon citratus (D.C.) Stapf) Presents Antitumoral Effect and Improves Chemotherapy Activity in Prostate Cancer Cells
- in-vitro, Pca, DU145
AntiTum↑, tumCV↓, TumCP↓, ROS?, TumCCA?, selectivity↑,
8189- LGE,    Lemongrass Extract Possesses Potent Anticancer Activity Against Human Colon Cancers, Inhibits Tumorigenesis, Enhances Efficacy of FOLFOX, and Reduces Its Adverse Effects
- vitro+vivo, CRC, NA
Apoptosis↑, Dose↝, selectivity↑, eff↑,
8184- LGE,    Cytotoxicity of citral against melanoma cells: The involvement of oxidative stress generation and cell growth protein reduction
- in-vitro, Melanoma, B16-BL6 - in-vitro, Nor, HaCaT
TumCP↓, ROS↑, DNAdam↑, P53↝, NO↓, NF-kB↓, ERK↓, Akt↓, selectivity↑,
8183- LGE,    Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
TumCG↓, selectivity↑, MMP↓, ROS↑, GSH↓, eff↓, p‑P53↑, BAX↑, Bcl-2↓, Bcl-xL↓, cl‑Casp3↑,
8333- LIN,    Linalool preferentially induces robust apoptosis of a variety of leukemia cells via upregulating p53 and cyclin-dependent kinase inhibitors
- in-vitro, AML, NA
TumCG↓, Apoptosis↑, selectivity↑, P53↑, CC(CDKs/cyclins)↑,
8331- LIN,    Antitumorigenic potential of linalool is accompanied by modulation of oxidative stress: an in vivo study in sarcoma-180 solid tumor model
- in-vivo, sarcoma, S180
ROS↑, *ROS↓, selectivity↑,
8328- LIN,    Linalool inhibits the growth of human T cell acute lymphoblastic leukemia cells with involvement of the MAPK signaling pathway
- in-vitro, AML, NA
TumCG↓, selectivity?, p‑ERK↓, p‑JNK↑,
8319- LIN,    Linalool monoterpene exerts potent antitumor effects in OECM 1 human oral cancer cells by inducing sub-G1 cell cycle arrest, loss of mitochondrial membrane potential and inhibition of PI3K/AKT biochemical pathway
- in-vitro, Oral, OECM-1 - in-vitro, Nor, FR-2
tumCV?, selectivity↑, Apoptosis↑, TumCCA↑, p‑PI3K↓, p‑Akt↓, MMP↓,
6464- LIN,  1,8-Cin,    Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells
- in-vitro, NSCLC, A549 - in-vitro, Nor, WI38
TumCP↓, TumCCA↑, selectivity↑, ROS↑, MMP↓, eff↓, TumCMig↓, Synergy↑,
6479- LIN,    Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer
- in-vivo, Colon, HCT116
Apoptosis↑, ROS↑, lipid-P↑, selectivity↑, TumCP↓, *toxicity↓,
8392- LT,    Revisiting Luteolin Against the Mediators of Human Metastatic Colorectal Carcinoma: A Biomolecular Approach
- in-vitro, CRC, HCT15 - in-vitro, CRC, HCT116 - in-vitro, CRC, DLD1 - in-vitro, CRC, HT-29 - in-vitro, Nor, RWPE-1
selectivity↑, β-catenin/ZEB1↓, GSK‐3β↑, AKT1↓, PI3K↓, p50↓,
8403- LT,    Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells
- in-vitro, CRC, HT-29
tumCV↓, selectivity↑, Apoptosis↑, Casp↑, MMP↓, Ca+2↑, BAX↑, Bcl-2↓, Cyt‑c↑, Casp9↑, Casp3↑, ROS↓, SOD↑, Catalase↑, GSH↑, antiOx↑, MAPK↑,
2925- LT,    Luteolin Induces Carcinoma Cell Apoptosis through Binding Hsp90 to Suppress Constitutive Activation of STAT3
- in-vitro, Cerv, HeLa - in-vitro, Nor, HEK293 - in-vitro, BC, MCF7
HSP90↓, p‑STAT3↓, Apoptosis↑, selectivity↑,
2904- LT,    Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons
- in-vitro, Park, SK-N-SH - in-vitro, AD, NA
*ROS↓, *neuroP↑, *MMP↑, *Catalase↑, *GSH↑, selectivity↑, *eff↑, *Cyt‑c↓,
8345- Lut,    Lutein inhibits breast cancer cell growth by suppressing antioxidant and cell survival signals and induces apoptosis
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, SOD2↓, HO-1↓, NRF2↓, p‑Akt↓, p‑ERK↓, NF-kB↓, Apoptosis↑, Casp3↑, Bcl-2↓, PARP↓, ROS↓, XBP-1↓, Dose↝, Risk↓, MMP↓, selectivity↑, p‑Akt↓,
8347- Lut,    Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms
- in-vitro, BC, NA
TumCG↓, TumCCA↑, selectivity↑, ROS↑, eff↓, P53↑, HSP60/HSPD1↑, cycF↑, CDC25↑, CDK6↑, ANAPC2↑, AURKB↑, GADD45A↑, BAX↑, Casp3↑, CASP4↑, Casp8↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR6↑, ChemoSen↑,
8349- Lut,    Lutein Inhibits Cell Growth and Activates Apoptosis via the PI3K/AKT/mTOR Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, HCC827 - in-vitro, Nor, BEAS-2B
*antiOx↑, PI3K↓, Akt↓, Apoptosis↑, selectivity↑,
8342- Lut,  Cisplatin,    Lutein Influences Cisplatin Sensitivity Through Differential Regulation of DNA Damage Response Genes in Breast Cancer Cells
- in-vitro, Nor, HUVECs - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
tumCV↓, DNAdam↑, selectivity↑, ROS↑, Casp3↑, BRCA1↓, Ku70/XRCC6↓, XRCC1↓, ChemoSen↑, NA↓,
1715- Lyco,    Pro-oxidant Actions of Carotenoids in Triggering Apoptosis of Cancer Cells: A Review of Emerging Evidence
- Review, Var, NA
antiOx↑, ROS↑, ChemoSen↑, selectivity↑, eff↓, Casp3↑, Casp7↑, Casp9↑, P53↑, BAX↑, DNAdam↑, mtDam↑, Synergy↑,
4783- Lyco,    Lycopene suppresses gastric cancer cell growth without affecting normal gastric epithelial cells
- in-vitro, GC, AGS - in-vitro, GC, SGC-7901 - in-vitro, Nor, GES-1
TumCG↓, TumCCA↑, Apoptosis↑, MMP↓, selectivity↑, cycE1↓, TP53↑, *antiOx↑,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
4796- Lyco,    The Anti-proliferation Effects of Lycopene on Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
TumCG↓, selectivity↑, *BioAv↑, *antiOx↑, *ROS↓, Risk↓, *cardioP↑,
2540- M-Blu,    Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
- Review, Var, NA - Review, AD, NA
*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,
8735- M-Blu,  PDT,    Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
*Dose↝, *TumCD↑, *selectivity↑,
8524- MAG,    Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, CRC, HCT116
Apoptosis↑, Akt?, BAD↑, Cyt‑c↑, cl‑Casp8↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, NA⇅, selectivity↑, p‑EGFR↓, p‑PI3K↓, p‑Akt↓,
8521- MAG,    Magnolol induces apoptosis via caspase-independent pathways in non-small cell lung cancer cells
- in-vitro, Lung, A549 - in-vitro, Lung, H520 - in-vitro, Lung, NCI-H441
TumCP↓, DNAdam↑, MMP↓, selectivity↑, BID↑, BAX↑, Cyt‑c↑, AIF↑, Endon↑, cl‑PARP↑, PI3K↓, Akt↓, ERK↓, p38↑, JNK↑,
8498- MAG,    Induction of apoptosis by magnolol via the mitochondrial pathway and cell cycle arrest in renal carcinoma cells
- in-vitro, Kidney, 786-O - in-vitro, RCC, OS-RC-2 - in-vitro, Nor, HK-2
Apoptosis↑, TumCCA↑, selectivity↑, TumCMig↓, TumCI↓, MPT↑, ROS↓, MMP↓, mtDam↑,
8506- MAG,    Magnolia officinalis Lignans induce apoptosis and epigenetic reprogramming via the miR-148a-3p/DNMT-1/UTF-1 axis in pancreatic cancer cells
- in-vitro, PC, Panc02 - in-vitro, PC, MIA PaCa-2
*Inflam↓, *antiOx↑, Ingr↝, tumCV↓, Apoptosis↑, ROS↑, MMP↓, Casp↑, selectivity↑, DNMT1↓, JAK2↓, STAT3↓, miR-148a↑, UTF1↑, IL6↓, survivin↓,
4534- MAG,    Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells
- in-vitro, Liver, HepG2 - in-vitro, CRC, COLO205
AntiCan↑, Apoptosis↑, selectivity↑, Ca+2↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,
4516- MAG,    Magnolol Induces Apoptosis and Suppresses Immune Evasion in Non-small Cell Lung Cancer Xenograft Models
- in-vivo, NSCLC, NA
selectivity↑, Apoptosis↑, TumCCA↑, Casp3↑, cycD1/CCND1↓, CDK4↓, VEGF↓, FOXP3↓, IDO1↓,
4536- MAG,    Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis
- in-vitro, Liver, HepG2 - in-vivo, CRC, COLO205
AntiCan↑, selectivity↑, TumCCA↑, P21↑, Apoptosis↑,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
8534- Matr,    Matrine induces apoptosis and autophagy in human lung adenocarcinoma cells via upregulation of Cavin3 and suppression of PI3K/AKT pathway
- in-vitro, Lung, A549 - in-vitro, Nor, MRC-5
TumCP↓, selectivity↑, Apoptosis↑, BAX↑, Bcl-2↓, TumAuto?, LC3II↑, Beclin-1/ATG6↑, p62↓, Cavin3↓, p‑PI3K↓, p‑Akt↓,
8933- MBS,  Rad,    The evaluation of radio-sensitivity of mung bean proteins aqueous extract on MCF-7, hela and fibroblast cell line
- in-vitro, BC, MCF7 - in-vitro, Cerv, HeLa
TumCP↓, selectivity?, RadioS↑, radioP↑,
8627- MBZ,    Treatment of breast and colon cancer cell lines with anti-helmintic benzimidazoles mebendazole or albendazole results in selective apoptotic cell death
- in-vitro, CRC, HT-29 - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCD↑, selectivity↑, Apoptosis↑, Casp3↑, DNAdam↑, MOMP↑, ROS↑, TumCCA↑, eff↓, RadioS↑,

Showing Research Papers: 401 to 450 of 677
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 677

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 3,   NA⇅, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 16,   antiOx⇅, 1,   Catalase↓, 8,   Catalase↑, 3,   ENOX2↓, 2,   Fenton↑, 8,   frataxin↑, 1,   GCLC↑, 1,   GPx↓, 2,   GPx↑, 2,   GPx4↓, 6,   GSH?, 1,   GSH↓, 45,   GSH↑, 5,   i-GSH∅, 1,   GSH/GSSG↓, 8,   GSSG↑, 3,   GSTs↝, 1,   H2O2↓, 2,   H2O2↑, 14,   mt-H2O2↑, 1,   HO-1↓, 3,   HO-1↑, 10,   HO-2↓, 1,   Iron↓, 4,   Iron↑, 4,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 2,   Keap1↝, 1,   lipid-P↓, 2,   lipid-P↑, 20,   lipidDe↓, 1,   MDA↓, 3,   MDA↑, 7,   i-MDA↑, 1,   NADH↓, 3,   NADH↑, 1,   mt-NADH↓, 1,   NADHdeh?, 1,   NOX↓, 2,   NOX↑, 1,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 11,   NRF2↑, 13,   NRF2∅, 1,   p‑NRF2↑, 1,   Prx↓, 1,   Prx3↑, 1,   Prx4↓, 1,   Prx4↑, 1,   PrxI↓, 1,   RNS↑, 3,   ROS?, 4,   ROS↓, 22,   ROS↑, 311,   ROS⇅, 10,   ROS↝, 3,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 4,   mt-ROS↑, 22,   RPM↑, 1,   SOD↓, 5,   SOD↑, 5,   SOD2↓, 3,   SOD2↑, 1,   Thiols↓, 3,   Trx↓, 4,   Trx↑, 1,   TrxR↓, 9,   TrxR1↓, 2,   mt-TrxR1↓, 1,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   IronCh∅, 1,   STEAP3↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   p‑CDC2↓, 1,   CDC25↓, 5,   CDC25↑, 1,   compI↓, 7,   compII↓, 1,   compIII↓, 2,   compIII↑, 1,   compIV↓, 1,   compV↓, 1,   EGF↓, 2,   ETC↓, 10,   ETC↝, 1,   HSP60/HSPD1↑, 1,   Insulin↓, 3,   mitResp↓, 8,   mitResp↑, 1,   mtDam↑, 38,   OCR↓, 9,   OCR↑, 5,   OXPHOS↓, 9,   OXPHOS↑, 5,   mt-OXPHOS↓, 2,   mt-OXPHOS↑, 2,   PDH↑, 1,   p‑PDH↓, 2,   p‑PDH↑, 1,   PGC-1α↑, 2,   PINK1↑, 1,   SDH↓, 1,   SIRT3↓, 1,   SIRT3↑, 4,   mt-TrxR2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   p‑ACC↑, 1,   ACLY↓, 1,   ALAT↓, 2,   AminoA↓, 1,   AMP↑, 1,   AMPK↑, 12,   p‑AMPK↑, 3,   ANXA7↑, 2,   ATP↓, 27,   ATP∅, 1,   ATP:AMP↓, 1,   cAMP↓, 1,   ECAR↓, 7,   ECAR↝, 1,   ECAR∅, 1,   FABP4↓, 1,   FAO↓, 1,   FAO↑, 1,   FASN↓, 1,   GAPDH↓, 2,   glucose↝, 1,   GlucoseCon↓, 16,   GlucoseCon∅, 1,   Glycolysis↓, 34,   Glycolysis∅, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 1,   H2S↑, 1,   Histones↝, 1,   HK2?, 1,   HK2↓, 11,   HK2∅, 1,   HMG-CoA↓, 5,   IDO1↓, 2,   KeyT↑, 1,   lactateProd↓, 21,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 5,   LDHA∅, 1,   LDL↓, 2,   lipidLev↓, 1,   lipoGen↓, 2,   MCT4↓, 1,   NAD↓, 2,   NADPH↓, 4,   NADPH↑, 2,   OAA↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 8,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 6,   PDKs↑, 1,   PFK↓, 2,   PFK1↓, 2,   PFKP↓, 1,   PKM1↑, 1,   PKM2↓, 9,   polyA↓, 1,   PPP↑, 1,   Pyruv↓, 1,   SCD1↓, 4,   SIRT1↓, 4,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,   TCA?, 1,   TCA↓, 1,   TS↓, 2,   Warburg↓, 9,  

Cell Death(tgid=5) ⓘ

AIF↑, 17,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 11,   Apoptosis↑, 256,   Apoptosis∅, 1,   mt-Apoptosis↑, 4,   aSmase↑, 1,   BAD↓, 2,   BAD↑, 9,   Bak↑, 6,   BAX?, 1,   BAX↓, 2,   BAX↑, 87,   BAX⇅, 2,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 25,   Bcl-2?, 1,   Bcl-2↓, 95,   Bcl-2↑, 1,   Bcl-xL↓, 20,   BID↑, 4,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↑, 2,   BNIP3?, 1,   Casp↓, 2,   Casp↑, 37,   Casp↝, 1,   Casp1↑, 2,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp3?, 1,   Casp3↓, 4,   Casp3↑, 120,   cl‑Casp3↑, 25,   proCasp3↓, 1,   pro‑Casp3↓, 1,   pro‑Casp3↑, 1,   CASP4↑, 1,   Casp6↓, 1,   Casp6↑, 2,   Casp7↑, 21,   cl‑Casp7↑, 2,   Casp8↓, 2,   Casp8↑, 38,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 76,   cl‑Casp9↑, 5,   pro‑Casp9↑, 1,   cFLIP↓, 2,   Cupro↑, 2,   Cyt‑c↓, 2,   Cyt‑c↑, 84,   Cyt‑c↝, 1,   Diablo↑, 4,   DR5↑, 13,   Endon↑, 2,   FADD↑, 2,   Fap1↓, 1,   Fas↓, 1,   Fas↑, 14,   FasL↑, 8,   Ferroptosis↑, 13,   GSDMC↑, 1,   GSDMD↑, 1,   IAP1↓, 2,   IAP1↑, 1,   IAP2/BIRC3↓, 2,   IAP2/BIRC3↑, 1,   ICAD↑, 1,   iNOS↓, 4,   Mcl-1↓, 10,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 6,   MDM2↑, 2,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↓, 2,   MOMP↑, 3,   Necroptosis↑, 3,   necrosis↑, 5,   NOXA↑, 2,   p38↓, 2,   p38↑, 8,   p‑p38↓, 1,   p‑p38↑, 6,   Paraptosis↑, 5,   PUMA↑, 5,   Pyro↑, 5,   RIP1↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   SK↓, 1,   survivin↓, 26,   TNFR 1↑, 1,   TRAIL↑, 5,   TumCD↓, 2,   TumCD↑, 50,   TUNEL↑, 1,   XIAP↓, 13,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 75,   Akt↑, 4,   p‑Akt↓, 28,   p‑Akt↑, 1,   AKT1↓, 3,   AMPKα↑, 1,   CaMKII ↓, 1,   Cavin3↓, 1,   CIP2A↓, 1,   cSrc↓, 1,   EF-1α↓, 1,   EGFR↓, 14,   p‑EGFR↓, 1,   ERK↓, 25,   ERK↑, 4,   p‑ERK↓, 10,   p‑ERK↑, 3,   HER2/EBBR2↓, 2,   Hippo↑, 1,   IGF-1R↓, 1,   p‑IGF-1R↓, 1,   IKKα↓, 3,   IKKα↑, 1,   IκB↓, 1,   IκB↑, 1,   JAK↓, 3,   JAK1↓, 2,   JAK1↑, 1,   JAK2↓, 7,   JNK↓, 6,   JNK↑, 16,   p‑JNK↑, 7,   MAPK↓, 17,   MAPK↑, 8,   p‑MAPK↑, 2,   MARK4↓, 2,   MEK↓, 4,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 36,   mTOR↑, 1,   mTOR⇅, 1,   p‑mTOR↓, 7,   mTORC2↑, 1,   p70S6↓, 1,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PI3K↓, 47,   PI3K↑, 2,   p‑PI3K↓, 7,   PI3K/Akt↓, 1,   PIAS-3↑, 1,   PKA↓, 2,   PKCδ↓, 4,   PKCδ↑, 2,   PTEN↑, 12,   Raf↓, 3,   c-Raf↓, 1,   RAS↓, 4,   p‑S6K↓, 2,   SHP1↑, 1,   Sp1/3/4↓, 8,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 34,   STAT3↑, 1,   p‑STAT3↓, 6,   p‑STAT3↑, 2,   mt-STAT3↓, 1,   STAT4↓, 1,   STAT6↓, 2,   p‑STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 1,   ATF4↑, 6,   ATF4↝, 1,   BRD4↓, 1,   ChrMod↑, 2,   cJun↑, 3,   cMyc↓, 17,   cMyc↑, 1,   DNMT1↓, 6,   DNMT1↑, 1,   DNMTs↓, 5,   EZH2↓, 4,   FOXO↑, 2,   FOXO3↓, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↑, 2,   GATA3↓, 1,   H3↑, 2,   ac‑H3↑, 4,   ac‑H3↝, 1,   H4↑, 1,   ac‑H4↓, 1,   ac‑H4↑, 4,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 22,   HDAC1↓, 4,   HDAC2↓, 2,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC8↓, 1,   miR-124-3p↓, 1,   miR-148a↑, 1,   miR-203↑, 1,   miR-21↓, 2,   miR-34a↑, 1,   miR-375↑, 1,   Myc↓, 1,   n-MYC↓, 1,   OCT4↓, 3,   other?, 1,   other↓, 2,   other↑, 15,   other⇅, 1,   other↝, 22,   other∅, 1,   PhotoS↑, 1,   PRMT6↓, 1,   SETBP1↓, 1,   SOX2↓, 2,   SOX4↓, 1,   SOX4↑, 1,   SUV39H↓, 1,   SUZ12↓, 1,   tumCV?, 1,   tumCV↓, 111,   tumCV↑, 4,   UTF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 21,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 2,   p‑eIF2α↓, 1,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 40,   ERStress↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 9,   HSP27↑, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 3,   HSP90↓, 7,   IRE1↑, 3,   PERK↓, 1,   PERK↑, 7,   p‑PERK↑, 1,   Proteasome?, 1,   Proteasome↓, 1,   UPR↑, 8,   XBP-1↓, 1,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 6,   ATG7↑, 3,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 6,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 2,   LC3B-II↓, 1,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↑, 9,   LC3s↓, 1,   lysoMP↑, 1,   MitoP↑, 1,   p62↓, 5,   p62↑, 6,   p‑p62↑, 1,   PARK2↑, 1,   SESN2↑, 1,   TumAuto?, 1,   TumAuto↓, 1,   TumAuto↑, 30,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↓, 1,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DNA-PK↑, 2,   DNAdam↓, 1,   DNAdam↑, 85,   DNArepair↓, 2,   DNArepair↑, 1,   FEN1↓, 1,   G9a↓, 1,   hTERT/TERT↓, 5,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   p16↑, 1,   P53↓, 2,   P53↑, 70,   P53↝, 3,   p‑P53↑, 3,   p53 Wildtype↓, 1,   p53 Wildtype↑, 1,   PARP↓, 9,   PARP↑, 13,   PARP↝, 1,   p‑PARP↑, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 58,   PARP1↑, 2,   cl‑PARP1↑, 2,   PCNA↓, 15,   PCNA↑, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 8,   TOP1↓, 4,   TOP1↝, 1,   TOP2↓, 2,   TOP2↑, 2,   TP53↑, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↑, 9,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   BRD4↓, 1,   CC(CDKs/cyclins)↓, 1,   CC(CDKs/cyclins)↑, 1,   CDK1↓, 7,   CDK1↑, 1,   CDK2↓, 29,   CDK2↑, 1,   CDK4↓, 33,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK6↓, 9,   CDK6↑, 3,   CDK8↓, 1,   CDKN1C/p57↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 5,   CycB/CCNB1↓, 15,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 48,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 16,   cycE1↓, 2,   cycF↑, 1,   E2Fs↓, 2,   FBXO5/EMI1↓, 1,   GADD34↑, 1,   GADD45A↑, 2,   Ki-67↓, 14,   P21?, 1,   P21↓, 5,   P21↑, 48,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 21,   PLK1↓, 1,   pRB↓, 1,   pRB↑, 1,   p‑pRB↓, 2,   p‑RB1↓, 4,   TubPol↓, 1,   TumCCA?, 3,   TumCCA↓, 4,   TumCCA↑, 178,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 3,   ALDH1A1↓, 2,   ALDH1A3↓, 1,   BMI1↓, 1,   CD133↓, 3,   CD24↓, 4,   cFos↓, 1,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 36,   CSCs↑, 1,   Diff↓, 3,   Diff↑, 7,   EP4/PTGER4↓, 1,   HH↓, 2,   HH↝, 1,   HMGCR↓, 1,   HMGCR↑, 1,   IGF-1↓, 3,   IGFBP3↑, 1,   Ki-67↓, 14,   mTORC1↓, 1,   p‑mTORC1↓, 1,   Nanog↓, 2,   Nestin↓, 2,   NOTCH↓, 6,   NOTCH↝, 1,   NOTCH1↓, 5,   NOTCH3↓, 2,   p300↓, 1,   SCF↓, 1,   Shh↓, 2,   STAT1↓, 1,   TOPflash↓, 1,   TumCG?, 1,   TumCG↓, 121,   TumCG↑, 4,   TumCG∅, 2,   TumCP?, 1,   TumCP↓, 140,   TumCP↑, 2,   Wnt↓, 21,   Wnt↝, 1,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 7,   ATPase↓, 1,   CA↓, 1,   Ca+2↓, 7,   Ca+2↑, 34,   Ca+2↝, 4,   i-Ca+2?, 1,   i-Ca+2↑, 2,   cal2↑, 1,   Cav1↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   i-Chl↑, 1,   Cofilin↓, 1,   p‑Cofilin↑, 1,   CTNNB1↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 20,   EMT↓, 37,   EpCAM↓, 1,   F-actin↓, 2,   FAK↓, 5,   FAK↑, 1,   FAK↝, 1,   p‑FAK↓, 2,   fascin↓, 1,   Fibronectin↓, 2,   FOSB↑, 1,   ITGB1↓, 2,   ITGB3↓, 1,   ITGB6↓, 1,   KRAS↓, 1,   MALAT1↓, 2,   MMP1↓, 1,   MMP2↓, 45,   MMP2↑, 1,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 45,   MMPs↓, 11,   MUC4↓, 1,   N-cadherin?, 1,   N-cadherin↓, 10,   N-cadherin↑, 1,   PAK1↓, 2,   PDGF↓, 4,   Rac1↓, 2,   RECK↑, 2,   Rho↓, 3,   ROCK1↓, 1,   Slug↓, 4,   Smad1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   Snail↓, 9,   TET1↑, 1,   TG2/TGase↓, 1,   TGF-β↓, 6,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↑, 6,   TIMP3↑, 1,   TSC1↑, 1,   TumCA↑, 1,   TumCI↓, 58,   TumCMig↓, 67,   TumMeta↓, 43,   TumMeta↑, 1,   Twist↓, 12,   uPA↓, 7,   Vim↓, 10,   Zeb1↓, 7,   ZEB2↓, 1,   α-tubulin↓, 2,   β-catenin/ZEB1↓, 23,   β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 55,   angioG↑, 3,   CD31/PECAM-1↓, 1,   CD31/PECAM-1↑, 1,   EGR1↑, 1,   Endoglin↑, 2,   HIF-1↓, 5,   Hif1a↓, 31,   Hif1a↑, 2,   HIF2a↓, 1,   Hypoxia↓, 1,   LOX1↓, 1,   NO↓, 2,   NO↑, 7,   PHDs↓, 1,   VCAM-1↓, 1,   VEGF↓, 43,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 9,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 2,   CellMemb↑, 2,   CLDN1↓, 1,   CTR1↑, 1,   EPR↑, 9,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT2↓, 2,   GLUT4↓, 1,   MMP?, 2,   MMP↓, 152,   MMP↝, 1,   MPT↓, 1,   MPT↑, 9,   NHE1↓, 2,   sonoP↑, 1,   SVCT-2↓, 1,   TRPC1↑, 1,   TRPM7↓, 1,   TRPV1↓, 1,   TRPV1↑, 4,   TRPV2↑, 1,   VGCC↑, 1,   VGSC↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CCR7↓, 1,   CD4+↑, 1,   CD44↓, 10,   CD47↓, 1,   CD8+↑, 4,   cDC2↓, 1,   p‑cDC2↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 32,   COX2/PTGS2↑, 4,   CXCc↓, 1,   CXCR4↓, 3,   DCells↑, 2,   DR4↑, 3,   DR6↑, 1,   FOXP3↓, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   Igs↑, 1,   IL1↓, 2,   IL1↑, 1,   IL10↓, 1,   IL10↑, 1,   IL1β↓, 7,   IL1β↑, 3,   IL2↑, 1,   IL6↓, 15,   IL8↓, 4,   IL8↑, 1,   Imm↑, 9,   Imm↝, 1,   INF-γ↑, 1,   Inflam↓, 28,   LIF↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MCT1↓, 1,   NF-kB↓, 71,   NF-kB↑, 9,   p‑NF-kB↑, 2,   NK cell↑, 8,   NLRP3↓, 1,   NLRP3↑, 3,   p50↓, 1,   p65↓, 3,   p‑p65↓, 1,   PD-L1↓, 3,   PGE2↓, 8,   PSA↓, 5,   RAGE↓, 1,   SOCS-3↓, 1,   SOCS-3↑, 1,   T-Cell↑, 2,   Th1 response↑, 1,   Th2↑, 1,   TLR4↓, 3,   TNF-α↓, 17,   TNF-α↑, 6,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   pH↝, 2,   e-pH↑, 1,   i-pH↓, 1,   i-pH↑, 2,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AhR↑, 1,   AR↓, 9,   CYP24A1↓, 1,   ER-α36↓, 2,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↓, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 6,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 31,   BioAv↑, 33,   BioAv↝, 5,   BioEnh↑, 1,   chemoR↓, 2,   ChemoSen↓, 1,   ChemoSen↑, 153,   ChemoSen∅, 3,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 8,   Dose↓, 10,   Dose↑, 15,   Dose⇅, 1,   Dose↝, 81,   Dose∅, 18,   eff?, 1,   eff↓, 87,   eff↑, 140,   eff↝, 22,   GSTP1/GSTπ↓, 1,   GSTZ1↓, 1,   Half-Life?, 1,   Half-Life↓, 6,   Half-Life↑, 4,   Half-Life↝, 11,   Half-Life∅, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 10,   P-gp/ABCB1∅, 1,   P450↓, 1,   P450↑, 1,   P450↝, 1,   RadioS↓, 1,   RadioS↑, 64,   selectivity?, 9,   selectivity↓, 10,   selectivity↑, 676,   selectivity↝, 2,   selectivity∅, 4,   Synergy↑, 91,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 9,   AST↓, 1,   B2M↓, 1,   BG↓, 4,   BloodF↑, 1,   BMD↑, 1,   BRCA1↓, 1,   p‑BRCA1↑, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 14,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↓, 1,   EZH2↓, 4,   Ferritin↓, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 5,   IL6↓, 15,   KeyT↑, 1,   KRAS↓, 1,   LDH?, 1,   LDH↓, 5,   LDH↑, 6,   Maspin↑, 1,   Myc↓, 1,   NOS2↓, 2,   NOS2↑, 1,   PD-L1↓, 3,   PSA↓, 5,   RAGE↓, 1,   SUZ12↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 55,   AntiCan∅, 1,   antiCG↓, 1,   AntiDiabetic↑, 1,   antiNeop↑, 1,   antiNeop∅, 1,   AntiTum↓, 1,   AntiTum↑, 24,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 6,   CardioT↓, 1,   chemoP↑, 29,   chemoPv↑, 21,   ChemoSideEff↓, 3,   fatigue↓, 1,   hepatoP↑, 10,   hepatoP∅, 1,   neuroP↑, 8,   NP/CIPN↓, 1,   OS↑, 30,   OS⇅, 1,   OS∅, 1,   Pain↓, 4,   PDE4↓, 1,   PFS↑, 1,   QoL↑, 9,   radioP↑, 16,   Remission↑, 2,   RenoP↑, 4,   Risk↓, 13,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 28,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 13,   toxicity∅, 5,   TumVol↓, 36,   TumW↓, 17,   Weight↑, 4,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 4,   Bacteria↓, 5,   GutMicro↑, 3,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 5,  
Total Targets: 956

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 2,   antiOx↑, 68,   mt-antiOx↑, 1,   ARE↑, 1,   Catalase↑, 21,   Copper↓, 1,   Fenton↓, 2,   GPx↑, 18,   GPx1↑, 1,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 18,   GSH/GSSG↑, 1,   GSR↑, 2,   GSSG↓, 1,   GSSG∅, 1,   GSTs↑, 7,   H2O2↓, 1,   H2O2↑, 1,   HDL↓, 1,   HDL↑, 3,   HO-1↑, 13,   hyperG↓, 1,   Iron↓, 2,   Iron↑, 1,   Iron∅, 1,   lipid-P↓, 15,   MDA↓, 12,   MPO↓, 2,   NOX↓, 1,   NOX4↓, 1,   Nrf1↑, 1,   NRF2↑, 21,   Prx↑, 1,   Prx4∅, 1,   RNS↓, 3,   ROS?, 2,   ROS↓, 64,   ROS↑, 4,   ROS∅, 18,   SAM-e↑, 1,   selenoP↑, 2,   SOD?, 1,   SOD↓, 1,   SOD↑, 23,   SOD1↑, 3,   SOD2↑, 2,   TAC↑, 1,   TBARS↓, 2,   VitC↑, 2,   VitE↓, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   EGF↓, 1,   mitResp↑, 1,   OCR↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACLY∅, 1,   ALAT↓, 4,   AMPK↑, 1,   ATP↑, 4,   ATP↝, 1,   ECAR↓, 1,   GlucoseCon↑, 2,   Glycolysis↓, 2,   Glycolysis↑, 1,   GSK‐3β↓, 2,   HK2↓, 1,   HMG-CoA↓, 1,   lactateProd↓, 1,   LDL↓, 4,   lipidLev↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 1,   NADPH∅, 1,   PFK↓, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 3,   Casp3∅, 1,   cl‑Casp8↑, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   Ferroptosis↓, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 5,   p38↓, 1,   survivin↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↓, 1,   ERK↓, 1,   ERK↑, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   JAK2↑, 1,   JNK↓, 1,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 1,   mTOR↓, 4,   PI3K↑, 2,   PKCδ?, 1,   PTEN↑, 1,   STAT↓, 1,   STAT3↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   other↓, 2,   other↑, 2,   other↝, 7,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   p‑PERK↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 10,   DNAdam↑, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cellSen↑, 1,   GADD45A↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   Diff↑, 1,   EP2↓, 1,   FGF↑, 1,   neuroG↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 4,   Ca+2↑, 1,   Ca+2↝, 2,   Ca+2∅, 1,   i-Ca+2↓, 1,   MMP13↓, 1,   MMP9↓, 1,   MMPs↑, 1,   PDGF↑, 1,   serineP↓, 1,   TGF-β↑, 2,   TIMP1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   α-tubulin↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   HIF-1↓, 1,   Hif1a↓, 1,   Hif1a↑, 2,   NO↓, 4,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 6,   GastroP↑, 1,   GLUT1↓, 1,   IBI↑, 1,   MMP↑, 2,   MMP∅, 2,   SVCT-2↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   COX2/PTGS2↓, 10,   FOXP3↑, 1,   HMGB1↓, 1,   IFN-γ↓, 3,   IL1↑, 1,   IL10↓, 1,   IL10↑, 2,   IL17↓, 2,   IL1β↓, 9,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 8,   IL8↓, 1,   Imm↑, 7,   Inflam↓, 61,   LPS↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 3,   NF-kB↓, 14,   NLRP3↓, 2,   NLRP3↑, 1,   PGE2↓, 2,   PSA∅, 1,   TLR4↓, 1,   TNF-α↓, 11,   TNF-α↑, 1,   Treg lymp↝, 1,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 3,   AChE↑, 1,   BDNF↑, 5,   MAOA↓, 2,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 7,   BACE/β-secretase↓, 1,   tau↓, 2,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 3,   PPARγ↑, 1,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 19,   BioAv↑, 21,   BioAv↝, 5,   BioEnh↑, 1,   CompStab↑, 2,   CompStab↝, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 13,   eff↑, 9,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 3,   Half-Life∅, 2,   P450↓, 1,   selectivity↑, 13,   selectivity⇅, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALP↓, 2,   AST↓, 4,   BG↓, 1,   BMD↑, 2,   BP↓, 4,   Calcium↑, 1,   creat↓, 2,   CRP↓, 3,   HbA1c↓, 1,   HOMA↓, 1,   hs-CRP↓, 2,   IL6↓, 8,   LDH↓, 1,   Mag↑, 1,   PSA∅, 1,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 2,   Urea↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 5,   antiAll↑, 7,   AntiArt↑, 2,   AntiCan↓, 1,   AntiCan↑, 9,   AntiDiabetic↑, 10,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 1,   cardioP↑, 16,   CardioT↓, 1,   chemoP↑, 12,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↑, 5,   diuretic↑, 1,   hepatoP↑, 11,   memory↑, 8,   neuroP↑, 28,   Obesity↓, 4,   OS↑, 3,   Pain↓, 3,   radioP↑, 5,   RenoP↑, 3,   Risk↓, 2,   Stress↓, 1,   Stroke↓, 2,   toxicity?, 2,   toxicity↓, 53,   toxicity↝, 11,   toxicity∅, 19,   Weight↑, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiViral↑, 3,   Bacteria↓, 15,   GutMicro↑, 5,   Inf↓, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 2,  
Total Targets: 313

Scientific Paper Hit Count for: selectivity, selectivity
35 Silver-NanoParticles
30 Magnetic Fields
20 Radiotherapy/Radiation
17 Piperlongumine
14 Selenium NanoParticles
13 Thymoquinone
12 Chemotherapy
12 Betulinic acid
12 Dandelion Root
10 Vitamin C (Ascorbic Acid)
10 doxorubicin
10 chitosan
10 Sulforaphane (mainly Broccoli)
10 Dichloroacetate
10 salinomycin
10 Fisetin
10 Phenethyl isothiocyanate
10 Shikonin
9 Capsaicin
9 Propolis -bee glue
9 Cisplatin
9 Magnetic Field Rotating
8 Carvacrol
8 Copper and Cu NanoParticles
8 Hydrogen Gas
8 Honokiol
8 Ivermectin
8 Magnolol
8 Quercetin
8 Selenite (Sodium)
7 Artemisinin
7 Berberine
7 Curcumin
7 Kaempferol
6 3-bromopyruvate
6 Fenbendazole
6 Apigenin (mainly Parsley)
6 Ashwagandha(Withaferin A)
6 Melatonin
6 Baicalein
6 Chrysin
6 Lemongrass Extract/Citral
6 EGCG (Epigallocatechin Gallate)
6 Gallic acid
6 HydroxyTyrosol
6 Linalool
5 Rosmarinic acid
5 Metformin
5 Boron
5 Selenium
5 Ellagic acid
5 Hibiscus sabdariffa
5 Indole-3-carbinol
5 Licochalcone A
4 Alpha-Lipoic-Acid
4 Phenylbutyrate
4 Gold NanoParticles
4 α-Bisabolol / Chamomile oil
4 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
4 chaetocin
4 diet FMD Fasting Mimicking Diet
4 diet Methionine-Restricted Diet
4 Eurycomanone
4 Eugenol
4 Graviola
4 phytic acid, Inositol hexakisphosphate
4 Lactoferrin/Talactoferrin
4 Luteolin
4 Lutein
4 Lycopene
4 mebendazole
4 Methyl Jasmonate
4 Morin
4 Parthenolide
4 α-Santalol/Sandalwood oil
4 Terpinen-4-ol / Tea Tree Oil
4 VitK3,menadione
3 1,8-Cineole
3 chemodynamic therapy
3 Allicin (mainly Garlic)
3 Astaxanthin
3 Atorvastatin
3 Caffeic acid
3 Centella asiatica / Gotu kola → asiaticoside
3 Citric Acid
3 Coenzyme Q10
3 Cynaropicrin
3 Date Fruit Extract
3 Shilajit/Fulvic Acid
3 γ-linolenic acid (Borage Oil)
3 Helleborus niger extracts – Christmas Rose
3 Isobavachalcone
3 Isoliquiritigenin
3 isoorientin
3 isoquercitrin
3 Recombinant Methioninase
3 Nimbolide
3 Urolithin
2 Dipyridamole
2 Berbamine
2 Bifidobacterium
2 immunotherapy
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Crocetin
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Hydroxycinnamic-acid
2 Dihydrocaffeic Acid
2 Docosahexaenoic Acid
2 Oxygen, Hyperbaric
2 D-limonene
2 Disulfiram
2 Electrical Pulses
2 Evodiamine
2 Fucoidan
2 Gambogic Acid
2 Ginkgo biloba
2 Geldanamycin
2 Gossypol/AT-101
2 Hyperthermia
2 Hyperoside
2 Inositol
2 iodine
2 Juglone
2 Licorice
2 Methylene blue
2 methylseleninic acid
2 Methylglyoxal
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Marjoram (Origanum majorana)
2 SonoDynamic Therapy UltraSound
2 Plumbagin
2 Sulfasalazine
2 polyethylene glycol
2 Silymarin (Milk Thistle) silibinin
2 Aflavin-3,3′-digallate
2 Vitexin
2 Zerumbone
1 Auranofin
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Glucose
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Sorafenib (brand name Nexavar)
1 5-Aminolevulinic acid
1 Baicalin
1 Bufalin/Huachansu
1 probiotics
1 Brucea javanica
1 Brutieridin–Melitidin Mixture
1 Boswellia (frankincense)
1 Bullatacin
1 Butyrate
1 Carnosic acid
1 urea
1 Thymol-Thymus vulgaris
1 Cat’s Claw
1 Cannabidiol
1 Chocolate
1 Calorie Restriction Mimetics
1 Carvone
1 Polyphenols
1 Cucurbitacin
1 Cysteamine
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 Diclofenac
1 diet Ketogenic
1 Docetaxel
1 Dimethyl Sulfoxide
1 Mistletoe/Viscum album Extracts
1 Echinacea
1 Ginkgo biloba-EGb 761
1 5-fluorouracil
1 PXD, phenoxodiol
1 Emodin
1 Fennel Oil/Foeniculum vulgare
1 ferumoxytol
1 Formononetin
1 Flaxseed/Linseed
1 Flaxseed Oil
1 olaparib/LYNPARZA
1 Garcinol
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginkgetin
1 Ginseng
1 Grapeseed extract
1 High-Ozonide Oil
1 Paclitaxel/Taxol
1 Gemcitabine (Gemzar)
1 isoflavones
1 Isovitexin
1 Lactobacillus
1 lambertianic acid
1 low dose naltrexone
1 Photodynamic Therapy
1 Matrine
1 Mung Bean Sprouts
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Mushroom Chaga, Inonotus obliquus
1 Bicarbonate(Sodium)
1 Oleuropein
1 Propyl gallate
1 temozolomide
1 borneol
1 Psoralidin
1 Pterostilbene
1 Resveratrol
1 irinotecan
1 triptolide
1 Ursolic acid
1 Vitamin B1/Thiamine
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1110  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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