MMP Cancer Research Results

MMP, ΔΨm, mitochondrial membrane potential: Click to Expand ⟱
Source:
Type:
Destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis.
Mitochondria are organelles within eukaryotic cells that produce adenosine triphosphate (ATP), the main energy molecule used by the cell. For this reason, the mitochondrion is sometimes referred to as “the powerhouse of the cell”.
Mitochondria produce ATP through process of cellular respiration—specifically, aerobic respiration, which requires oxygen. The citric acid cycle, or Krebs cycle, takes place in the mitochondria.
The mitochondrial membrane potential is widely used in assessing mitochondrial function as it relates to the mitochondrial capacity of ATP generation by oxidative phosphorylation. The mitochondrial membrane potential is a reliable indicator of mitochondrial health.
In cancer cells, ΔΨm is often decreased, which can lead to changes in cellular metabolism, increased glycolysis, increased reactive oxygen species (ROS) production, and altered cell death pathways.

The membrane of malignant mitochondria is hyperpolarized (−220 mV) in comparison to their healthy counterparts (−160 mV), which facilitates the penetration of positively charged molecules to the cancer cells mitochondria.
The MMP is a critical indicator of mitochondrial function, directly reflecting the organelle's capacity to generate ATP through oxidative phosphorylation.


Scientific Papers found: Click to Expand⟱
7139- GI,    6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer
- vitro+vivo, Lung, A549 - in-vitro, Melanoma, A375 - in-vitro, GBM, U251
HSP60/HSPD1↓, Apoptosis↑, TumCCA↑, mtDam↑, ERK↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, TumCG↓, TumCP↓, TumCG↓, Bcl-2↓, survivin↓, BAX↑, MMP↓, Dose↝,
7283- Gins,    Ginsenoside-Rh2-induced mitochondrial depolarization and apoptosis are associated with reactive oxygen species- and Ca2+-mediated c-Jun NH2-terminal kinase 1 activation in HeLa cells
- in-vitro, Cerv, HeLa - in-vitro, BC, MCF-10AT - in-vitro, BC, MCF7
MMP↓, Casp↑, BAX↑, Ca+2↑, ROS↑, cJun↑,
7282- Gins,    Ginsenoside Rh2 stimulates the production of mitochondrial reactive oxygen species and induces apoptosis of cervical cancer cells by inhibiting mitochondrial electron transfer chain complex
- in-vitro, Cerv, NA
compI↓, compIII↓, ETC↓, ROS↑, Apoptosis↑, tumCV↓, selectivity↑, MMP↓, ATP↓, OXPHOS↓, ECAR↓, Glycolysis↓,
4513- GLA,    Antineoplastic Effects of Gamma Linolenic Acid on Hepatocellular Carcinoma Cell Lines
- in-vitro, Liver, HUH7
TumCP↓, ROS↑, Apoptosis↑, HO-1↑, Trx↑, lipid-P↑, eff↓, MMP↓, DNAdam↑, selectivity↑,
4506- GLA,    A basal level of γ-linolenic acid depletes Ca2+ stores and induces endoplasmic reticulum and oxidative stresses to cause death of breast cancer BT-474 cells
- in-vitro, BC, BT474
Apoptosis↓, Ca+2↑, MMP↓, p‑eIF2α↑, CHOP/DDIT3↑, ER Stress↑, ROS↑,
1901- GoldNP,  Rad,    The role of thioredoxin reductase in gold nanoparticle radiosensitization effects
- in-vitro, Lung, A549
MMP↓, ROS↑, RadioS↑, TrxR↓,
1904- GoldNP,  AgNPs,    Unveiling the Potential of Innovative Gold(I) and Silver(I) Selenourea Complexes as Anticancer Agents Targeting TrxR and Cellular Redox Homeostasis
- in-vitro, Lung, H157 - in-vitro, BC, MCF7 - in-vitro, Colon, HCT15 - in-vitro, Melanoma, A375
TrxR↓, selectivity↑, eff↑, eff↝, ROS↑, MMP↓, Apoptosis↑, eff↑,
7315- Gos,    Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells
- vitro+vivo, CRC, HT29 - in-vitro, CRC, COLO205
TumCD↑, Casp3↑, Casp6↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-xL↓, ROS↑, i-H2O2↑, eff↓, mtDam↑, MMP↓, Cyt‑c↑, AIF↑, TumCG↓,
7311- Gos,    Systematic Review of Gossypol/AT-101 in Cancer Clinical Trials
- Review, CLL, NA
Dose↝, toxicity↓, PFS↓, OS↑, Synergy↑, BioAv↑, Bcl-2↓, ROS↑, MOMP↑, Dose↑, Casp3↑, Casp9↑, MMP↑, VEGF↓, APE1/APEX1↓, ChemoSen↑, RadioS↑, toxicity↑, AST↑, ALAT↑,
7314- Gos,    The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro
- in-vitro, Melanoma, A375
Dose↝, ROS↑, selectivity↑, Half-Life↓, MMP↓, BioAv↑,
7338- Gra,    Pharmacological Activities of Soursop (Annona muricata Lin.)
- Review, Var, NA
AntiCan↑, *AntiDiabetic↑, *Diar↓, *Bacteria↓, *AntiViral↑, *Wound Healing↑, MMP2↓, MMP9↓, MMP↓, ROS↑, TumCCA↑, BAX↑, Bcl-2↓, Casp3↑, *BAX↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *NO↑, *PGE2↑, *HSP70/HSPA5↑,
7335- Gra,    Effect of Annona muricata (Soursop) on Patients with Cancer: A Systematic Review
- Review, Var, NA
TumCG↓, Casp↑, Inflam↓, toxicity↓, other↑, TumCCA↑, Apoptosis↑, TumAuto↑, ATP↓, AIF↑, MMP↓, MOMP↑, Cyt‑c↑, selectivity↑, hepatoP∅,
2438- Gra,    Emerging therapeutic potential of graviola and its constituents in cancers
- Review, Var, NA
Hif1a↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, MUC4↓, TumCCA↑, MMP↓, NF-kB↓, ROS↓, Bax:Bcl2↑, ER(estro)↓, cycD1/CCND1↓, chemoPv↑, hepatoP↑,
845- Gra,    A Review on Annona muricata and Its Anticancer Activity
- Review, Var, NA
GlucoseCon↓, ATP↓, HIF-1↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ERK↓, Akt↓, Apoptosis↑, NF-kB↓, ROS↑, Bax:Bcl2↑, MMP↓, Casp3↑, Casp9↑, p‑JNK↓,
841- Gra,    The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach
- in-vitro, CRC, HT-29 - in-vitro, Nor, CCD841
PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,
835- Gra,    Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB
- in-vitro, Lung, A549
ROS↑, MMP↓, BAX↑, Bcl-2↓, Cyt‑c↑, Casp9↑, Casp3↑, Apoptosis↑, TumCCA↑,
858- Gra,    Annona muricata leaves induce G₁ cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116
TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Casp↑, BAX↑, Bcl-2↓, TumCMig↓, TumCI↓,
850- Gra,    Selective cytotoxic and anti-metastatic activity in DU-145 prostate cancer cells induced by Annona muricata L. bark extract and phytochemical, annonacin
- in-vitro, PC, PC3 - in-vitro, Pca, DU145
ROS∅, MMP∅, Casp3↑, Casp7↑, VEGF↓,
1233- Gra,    THERAPEUTIC ELIGIBILITY OF GRAVIOLA VERSUS 5-FLUOROURACIL: APOPTOTIC EFFICACY ON HEAD AND NECK SQUAMOUS CELL CARCINOMA AND NORMAL EPITHELIUM CELLS
- in-vitro, HNSCC, NA
Apoptosis↑, MMP↓,
1232- Gra,    Graviola: A Systematic Review on Its Anticancer Properties
- Review, Var, NA
EGFR↓, cycD1/CCND1↓, Bcl-2↓, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, BAX↑, Cyt‑c↑, Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ATP↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
7483- H2,  Cisplatin,    Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism
- in-vivo, Nor, HK-2
RenoP↑, BHB↑, HMGCS2↑, chemoP↑, *IL2↓, *IL6↓, *MCP1/CCL2↓, *TNF-α↓, *KeyT↝, *Inflam↓, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *PGC-1α↑, *BUN↓, *creat↓,
1644- HCAs,  PBG,    Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis
- in-vitro, Pca, LNCaP
NF-kB↓, TRAILR↑, Casp8↑, Casp3↑, MMP↓, Dose?,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
7357- HibSad,    Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells
- in-vitro, CRC, LoVo
Apoptosis↑, AMPK↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑Casp3↑, Dose↝, mtDam↑, MMP↓, Akt↓,
7356- HibSad,    Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
AntiCan↑, Apoptosis↑, selectivity↑, ChemoSen↑, ROS↑, MMP↓, eff↑,
7339- Hne,    Apoptosis-inducing activity of Helleborus niger in ALL and AML
- in-vitro, AML, NA
TumCP↓, DNAdam↓, Casp3↑, MMP↓, eff↑, Apoptosis↑,
7468- HNK,    Honokiol and Its Emerging Role in Breast Cancer Therapy
- Review, BC, NA
*ROS↓, *Inflam↓, CSCs↓, ChemoSen↑, BioAv↑, ROS↑, MMP↓, mtDam↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, BAX↑, p‑STAT3↓, AMPK↑, miR-34a↑, EMT↓, HH↓, Shh↓, Gli1↓, PTCH1↓, NF-kB↓, TNF-α↓, IL6↓, Glycolysis↓, GlucoseCon↓, BioAv↓, BioAv↓, Half-Life↝,
2869- HNK,    Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *motorD↑, *Aβ↓, *p‑tau↓, *cognitive↑, *memory↑, *ERK↑, *p‑Akt↑, *PPARγ↑, *PGC-1α↑, *MMP↑, *mt-ROS↓, *SIRT3↑, *IL1β↓, *TNF-α↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *NF-kB↓, *GSK‐3β↓, *β-catenin/ZEB1↑, *Ca+2↓, *AChE↓, *SOD↑, *Catalase↑, *GPx↑,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
2887- HNK,    Honokiol Restores Microglial Phagocytosis by Reversing Metabolic Reprogramming
- in-vitro, AD, BV2
*Glycolysis↑, *ATP↑, *ROS↓, *MMP↑, *OXPHOS↑, *PPARα↑, *PGC-1α↑,
2889- HNK,  doxoR,    Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice
- in-vivo, Nor, NA
*SIRT3↑, chemoP↑, *cardioP↑, mtDam↑, ROS↑, *ROS↓, *MMP↑,
2071- HNK,    Identification of senescence rejuvenation mechanism of Magnolia officinalis extract including honokiol as a core ingredient
- Review, Nor, HaCaT
*ROS↓, *antiOx↑, *AntiAge↑, *MMP↑, *ECAR↓, *Glycolysis↓, *PAR-2↓, *CXCL12↑, *BMAL1↑, *mt-ROS↓, *OXPHOS↓,
2073- HNK,    Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- in-vitro, OS, U2OS - in-vivo, NA, NA
TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,
4238- HNK,    Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint
- Review, AD, NA - NA, Park, NA
*BDNF↑, *hepatoP↑, *ALAT↓, *AST↓, *TNF-α↓, *SIRT3↑, *Aβ↓, *Apoptosis↓, *ROS↓, *MMP↑, *Ca+2↓, *Casp3↓, *Ach↑, *PPARγ↑, *PGC-1α↑, *motorD↑, *TNF-α↓, *IL1β↓,
886- HPT,    Impact of hyper- and hypothermia on cellular and whole-body physiology
- Analysis, Var, NA
MMP↓, OXPHOS↓, ATP↓, ROS↑, Apoptosis↑, Cyt‑c↑,
7535- HT,    Hydroxytyrosol acetate from olive leaves (Olea Europaea L.) induces apoptosis via mitochondrial pathway in BEL7402 cell line
- in-vitro, Liver, Bel-7402
TumCP↓, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, Apoptosis↑,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
4641- HT,    Hydroxytyrosol induced ferroptosis through Nrf2 signaling pathway in colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Ferroptosis↑, Iron↑, lipid-P↑, ROS↑, GSH↓, MMP↓, GPx4↓, TLR1↑, eff↓, NRF2↓, ROS↑,
7557- HYP,    Hyperoside protects the blood-brain barrier from neurotoxicity of amyloid beta 1-42
- in-vitro, AD, NA
*neuroP↑, *Aβ↓, *Casp3↑, *ZO-1↓, *CLDN5↓, *OCLN↓, *MMP2↑, *MMP↓,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7546- HYP,    Hyperoside attenuates hydrogen peroxide-induced L02 cell damage via MAPK-dependent Keap₁-Nrf₂-ARE signaling pathway
- in-vitro, Nor, L02
*TAC↑, *GPx↑, *Catalase↑, *ROS↓, *MMP↓, *LDH↑, *HO-1↑, *NRF2↑,
7554- HYP,    Effect of hyperoside on the apoptosis of A549 human non‑small cell lung cancer cells and the underlying mechanism
- in-vitro, NSCLC, A549
tumCV↓, Apoptosis↑, p‑MAPK↑, JNK↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, AIF↑,
7612- I3C,    Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells
- in-vitro, Nor, MCF10
selectivity↑, Bax:Bcl2↓, Bcl-xL↓, BAX↑, MMP↓, Cyt‑c↑, TumCD↑,
7584- I3C,    Functional effect of indole-3 carbinol in the viability and invasive properties of cultured cancer cells
- in-vitro, Cerv, HeLa - in-vitro, CRC, HCT8 - in-vitro, Liver, HepG2
TumCP↓, Apoptosis↑, TumCI↓, *antiOx↑, AhR↑, MMP↓, Casp3↑, Casp8↑,
7586- I3C,    Bax translocation to mitochondria is an important event in inducing apoptotic cell death by indole-3-carbinol (I3C) treatment of breast cancer cells
- in-vitro, BC, NA
TumCG↓, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, TumCCA↑,
7591- I3C,    Indole-3-carbinol (I3C)-induced apoptosis in nasopharyngeal cancer cells through Fas/FasL and MAPK pathway
- in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, XIAP↓, IAP1↓, survivin↓, Diablo↑, Cyt‑c↑, HTRA2/Omi/PARK13↑, mtDam↑, Fas↑, FasL↑,
7385- IBC,    Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction
- vitro+vivo, Lung, A549 - in-vitro, BC, 4T1
Apoptosis↑, necrosis↑, ROS↑, mtDam↑, Ca+2↑, MPT↑, MMP↓, AntiCan↑, *AntiBio↑, *Inflam↓, *antiOx↓, *neuroP↑, p‑Akt↓, DHODH↓, Diff↑, MAPK↑,
7767- IBC,    Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway
- vitro+vivo, GC, NA
TumCG↓, ROS↑, DHODH↓, MMP↓, cGAS–STING↑, Imm↑, mtDam↑,
7770- IBC,    Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction
- in-vitro, Lung, NA - vitro+vivo, BC, 4T1
necrosis↑, ROS↑, mtDam↑, Ca+2↑, NA↑, MMP↓, TumCG↓,

Showing Research Papers: 401 to 450 of 814
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 814

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 5,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 10,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 18,   Catalase↑, 4,   Ceru↓, 1,   Copper↑, 1,   CoQ10↝, 1,   ENOX2↓, 1,   Fenton↑, 4,   GCLM↓, 1,   GPx↓, 4,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 17,   GSH↓, 76,   GSH↑, 7,   i-GSH∅, 1,   mt-GSH↓, 1,   GSH/GSSG↓, 7,   GSR↓, 2,   GSR↑, 1,   GSSG↑, 1,   ox-GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 2,   GSTs↝, 1,   H2O2?, 1,   H2O2↓, 1,   H2O2↑, 9,   i-H2O2↑, 1,   mt-H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 10,   HO-1⇅, 1,   HO-2↓, 1,   Iron↓, 1,   Iron↑, 10,   i-Iron↑, 1,   c-Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 5,   lipid-P↑, 32,   lipid-P↝, 1,   MDA↓, 2,   MDA↑, 13,   NADH↓, 5,   NOX↑, 1,   NOX4↑, 1,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 20,   NRF2↑, 20,   NRF2⇅, 1,   NRF2↝, 1,   p‑NRF2↓, 1,   p‑NRF2↑, 1,   Prx↓, 1,   RNS↓, 1,   ROS?, 5,   ROS↓, 28,   ROS↑, 527,   ROS⇅, 9,   ROS↝, 2,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 6,   m-ROS↑, 1,   mt-ROS↑, 16,   SOD↓, 22,   SOD↑, 2,   mt-SOD↑, 1,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 5,   SOD2↑, 4,   TAC↓, 3,   TBARS↑, 3,   Thiols↓, 3,   Thiols↝, 1,   TKT↓, 1,   Trx↓, 5,   Trx↑, 2,   Trx1↓, 1,   Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 18,   TrxR↑, 1,   TrxR1↓, 2,   xCT/SLC7A11↓, 7,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 2,   IronCh↑, 2,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 3,   BCR↓, 1,   CDC2↓, 6,   CDC25↓, 15,   CDC25↝, 1,   compI↓, 8,   compI↑, 1,   compII↓, 2,   compII↑, 1,   compIII↓, 5,   compV↓, 1,   EGF↓, 2,   ETC↓, 18,   ETC↝, 2,   FIS1↓, 1,   HSP60/HSPD1↓, 2,   HTRA2/Omi/PARK13↑, 1,   IDH2↓, 1,   MFN2↓, 1,   mitResp↓, 9,   mitResp↑, 5,   MKK7↓, 1,   mRET↑, 1,   mtDam↓, 2,   mtDam↑, 56,   OCR↓, 20,   OCR↑, 1,   OXPHOS↓, 10,   OXPHOS↑, 4,   OXPHOS↝, 2,   OXPHOS∅, 1,   mt-OXPHOS↓, 1,   mt-OXPHOS↑, 1,   PDH↑, 2,   PDH↝, 1,   p‑PDH↓, 2,   PGC-1α↑, 1,   PHB↑, 1,   PINK1↑, 6,   SDH↓, 1,   SIRT3↓, 3,   SIRT3↑, 2,   SSBP1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 1,   ACC↓, 1,   ACC↑, 2,   ACSL4↑, 1,   ALAT↓, 4,   ALAT↑, 1,   ALAT∅, 1,   ALDOA↓, 1,   AMP↑, 2,   AMPK↓, 1,   AMPK↑, 33,   p‑AMPK↑, 4,   p‑AMT/GCST/T-protein↑, 1,   ANXA7↑, 2,   ATP↓, 60,   ATP↑, 3,   ATP↝, 1,   ATP∅, 1,   e-ATP↑, 1,   BHB↑, 1,   CAIX/CA9↓, 1,   DHODH↓, 2,   ECAR↓, 3,   ECAR↝, 1,   FAO↑, 1,   FASN↓, 6,   G6PD↓, 1,   GLS↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 18,   GlucoseCon↑, 1,   GlutMet↓, 1,   Glycolysis↓, 41,   GSK‐3β↓, 7,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 4,   H2S↑, 1,   HK1↓, 1,   HK2↓, 29,   HMG-CoA↓, 2,   HMGCS2↑, 1,   lactateProd↓, 18,   lactateProd↑, 3,   LDHA↓, 11,   LDL↓, 4,   NAD↓, 1,   NADPH↓, 1,   NADPH↑, 3,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 11,   PDKs↓, 6,   PFK↓, 8,   PFKP↓, 1,   PKM2↓, 15,   PKM2↑, 1,   PKM2∅, 1,   PPP↓, 1,   SCD1↓, 2,   SIRT1↓, 13,   SIRT1↑, 4,   SIRT2↓, 1,   SIRT2↑, 1,   SLC25A1↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 1,   TCA↑, 1,   TS↓, 1,   Warburg↓, 9,  

Cell Death(tgid=5) ⓘ

AIF↑, 36,   AIF↝, 1,   APAF1↑, 12,   Apoptosis?, 4,   Apoptosis↓, 8,   Apoptosis↑, 385,   mt-Apoptosis↑, 4,   ASC↑, 1,   ASK1↑, 2,   BAD↓, 3,   BAD↑, 21,   Bak↓, 1,   Bak↑, 15,   BAX↓, 4,   BAX↑, 189,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 57,   Bcl-2↓, 196,   Bcl-2↑, 2,   Bcl-2∅, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 41,   Bcl-xL↑, 1,   BID↓, 1,   BID↑, 15,   p‑BID↓, 1,   cl‑BID↑, 3,   BIM↓, 1,   BIM↑, 10,   BNIP3?, 1,   BNIP3↑, 3,   BNIP3↝, 2,   BOK↑, 1,   Casp↓, 2,   Casp↑, 76,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 2,   Casp10↑, 2,   Casp12↑, 11,   cl‑Casp12↑, 1,   pro‑Casp12↓, 1,   Casp2↑, 1,   Casp3?, 3,   Casp3↓, 6,   Casp3↑, 276,   cl‑Casp3↓, 2,   cl‑Casp3↑, 51,   proCasp3↓, 1,   proCasp3↑, 3,   pro‑Casp3↑, 1,   CASP4↑, 2,   Casp6↑, 2,   Casp7↑, 20,   cl‑Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 65,   Casp8∅, 2,   cl‑Casp8↑, 10,   proCasp8↑, 2,   Casp9↓, 1,   Casp9↑, 178,   cl‑Casp9↓, 1,   cl‑Casp9↑, 23,   proCasp9↓, 2,   proCasp9↑, 3,   cFLIP↓, 7,   Cupro↑, 2,   Cyt‑c↓, 4,   Cyt‑c↑, 243,   Cyt‑c↝, 1,   Diablo↑, 14,   DR5↑, 29,   Endon↑, 5,   FADD↑, 8,   Fap1↓, 2,   Fas?, 1,   Fas↓, 3,   Fas↑, 32,   FasL↓, 1,   FasL↑, 16,   Ferroptosis↑, 17,   GranB/GZMB↝, 1,   GSDMD↑, 1,   GSDME-N↑, 1,   HEY1↓, 1,   IAP1↓, 9,   IAP2/BIRC3↓, 4,   ICAD↓, 1,   ICD↑, 4,   iNOS↓, 15,   iNOS↑, 1,   Mcl-1↓, 20,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 12,   p‑MDM2↓, 1,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 7,   NAIP↓, 1,   Necroptosis↑, 6,   necrosis↑, 9,   NOXA↑, 3,   p38↓, 8,   p38↑, 27,   p‑p38↓, 2,   p‑p38↑, 5,   Paraptosis↑, 4,   Perforin↝, 1,   PUMA↓, 1,   PUMA↑, 5,   Pyro↑, 5,   RIP3↑, 3,   p‑RIP3↑, 2,   survivin↓, 49,   TNFR 1↑, 3,   TRAIL↑, 8,   TRAIL⇅, 1,   TRAILR↑, 5,   TumCD↑, 46,   TUNEL↑, 1,   XIAP↓, 31,   XIAP↑, 1,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 145,   Akt↑, 5,   p‑Akt↓, 37,   p‑Akt↑, 1,   AKT1↓, 2,   Akt2↓, 1,   AMPKα↑, 2,   CIP2A↓, 2,   CK2↓, 3,   cMET↓, 1,   p‑cMET↑, 1,   EF-1α↓, 1,   EGFR↓, 31,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 51,   ERK↑, 9,   p‑ERK↓, 18,   p‑ERK↑, 7,   e-ERK↑, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 11,   HGF/c-Met↓, 1,   Hippo↓, 1,   Hippo↑, 1,   Hippo↝, 1,   HRAS↓, 1,   IGF-1R↓, 2,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 3,   IKKα↑, 3,   p‑IKKα↓, 1,   IκB↑, 2,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 5,   JAK1↓, 2,   JAK1↑, 2,   JAK2↓, 7,   JAK3↓, 1,   JNK↓, 8,   JNK↑, 30,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 8,   MAP2K1/MEK1↓, 1,   MAPK↓, 32,   MAPK↑, 19,   p‑MAPK↓, 1,   p‑MAPK↑, 4,   MARK4↓, 1,   MEK↓, 8,   p‑MEK↑, 1,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 71,   mTOR↑, 1,   p‑mTOR↓, 14,   mTORC2↓, 3,   NRAS↓, 1,   p70S6↓, 3,   p‑p70S6↑, 1,   P70S6K↓, 5,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 99,   PI3K↑, 3,   p‑PI3K↓, 6,   PI3K/Akt↓, 3,   PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 2,   PKCδ↓, 12,   p‑PKCδ↓, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 2,   PTEN↑, 18,   Raf↓, 6,   c-Raf↓, 1,   RAS↓, 11,   RIP1↓, 1,   RIP1↑, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 15,   Src↑, 1,   STAT↓, 3,   STAT3↓, 61,   STAT3↑, 3,   STAT3↝, 1,   p‑STAT3↓, 9,   p‑STAT3↑, 3,   STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 12,   ATFs↑, 1,   ChrMod↑, 1,   ChrMod↝, 1,   cJun↓, 8,   cJun↑, 6,   p‑cJun↑, 2,   cMyc↓, 20,   cMyc↑, 1,   DNMT1↓, 2,   DNMT3B↓, 1,   DNMTs↓, 6,   EZH2↓, 3,   FOXM1↓, 3,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 3,   FOXO3↑, 7,   FOXO3↝, 1,   FOXO4↓, 1,   FOXO4↑, 1,   GATA3↑, 1,   H3↓, 1,   H3↑, 2,   p‑H3↓, 1,   p‑H3↑, 1,   ac‑H3↑, 2,   H4↑, 1,   ac‑H4↑, 2,   HATs↓, 5,   HATs↑, 3,   HDAC↓, 26,   HDAC1↓, 4,   HDAC10↑, 1,   HDAC2↓, 5,   HDAC3↓, 4,   HDAC6↓, 2,   HDAC8↓, 2,   HMTs↓, 1,   miR-106b↓, 1,   miR-124-3p↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-148a↑, 1,   miR-155↓, 1,   miR-203↑, 1,   miR-21↓, 4,   miR-22↑, 2,   miR-34a↑, 4,   MTA2↓, 1,   Myc↓, 5,   n-MYC↓, 1,   OCT4↓, 12,   other↓, 7,   other↑, 9,   other↝, 12,   sonoS↑, 1,   SOX2↓, 11,   SOX4↓, 3,   SOX9↓, 1,   SUV39H↓, 1,   TCF-4↓, 2,   TFE3↑, 2,   tumCV?, 2,   tumCV↓, 106,   tumCV↑, 1,   tumCV∅, 1,   UTF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   cl‑ATF6↑, 2,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 38,   cl‑CHOP/DDIT3↑, 1,   CRT↑, 1,   eIF2α↓, 1,   eIF2α↑, 9,   p‑eIF2α↓, 1,   p‑eIF2α↑, 4,   ER Stress↓, 3,   ER Stress↑, 71,   ER Stress↝, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 24,   GRP78/BiP↝, 1,   GRP94↑, 4,   HSF1↓, 1,   HSP27↓, 8,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP72↓, 1,   HSP90↓, 12,   HSP90↑, 2,   HSPs↓, 1,   HTRA↓, 1,   IRE1↑, 6,   PDI↑, 1,   PERK↑, 13,   Proteasome↓, 1,   UPR↓, 1,   UPR↑, 17,   XBP-1↓, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 3,   ATG5↑, 11,   ATG7↑, 3,   autoF↓, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 16,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3A↑, 2,   LC3B↑, 6,   LC3B-II↑, 3,   LC3II↑, 21,   LC3s↑, 1,   lysoMP↑, 2,   lysosome↝, 1,   MitoP↓, 1,   MitoP↑, 5,   p62↓, 11,   p62↑, 5,   PARK2↑, 5,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 71,   TumAuto⇅, 2,   ULK1/ATG1↑, 1,   p‑ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATM↑, 5,   BRCA1↓, 3,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 1,   DFF45↑, 2,   DNA-PK↑, 2,   DNAdam↓, 5,   DNAdam↑, 121,   mt-DNAdam↑, 1,   DNArepair↓, 2,   hTERT/TERT↓, 9,   MGMT↓, 1,   p16↑, 1,   P53↓, 3,   P53↑, 113,   P53↝, 2,   P53∅, 1,   p‑P53↑, 10,   ac‑P53↑, 1,   p53 Wildtype∅, 1,   PARP↓, 10,   PARP↑, 22,   p‑PARP↑, 2,   cl‑PARP↓, 3,   cl‑PARP↑, 109,   PARP1↑, 2,   cl‑PARP1↑, 3,   PCNA↓, 30,   POLD1↓, 1,   SIRT6↓, 2,   SIRT6↑, 1,   Telomerase↓, 13,   TOP1?, 1,   TOP1↓, 13,   TOP1∅, 1,   TOP2↓, 5,   TP53↓, 3,   TP53↑, 4,   TRF2↓, 1,   γH2AX↑, 12,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 18,   CDK1↑, 2,   CDK1↝, 1,   p‑CDK1↓, 1,   CDK2↓, 38,   CDK2↑, 2,   CDK4↓, 43,   p‑CDK4↓, 1,   CDK6↓, 15,   CDK6↑, 2,   CDK7↓, 1,   CDK8↓, 1,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 2,   CHK1↑, 1,   CHK1↝, 1,   Chk2↓, 2,   Chk2↑, 3,   ChrCon↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 14,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 23,   CycB/CCNB1↑, 5,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 79,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 3,   cycE/CCNE↓, 22,   cycE1↓, 2,   E2Fs↓, 2,   E2Fs↑, 1,   GADD45A↓, 1,   Ki-67↓, 22,   MAD↓, 1,   mitA↓, 1,   mitA↑, 2,   p19↑, 1,   P21?, 2,   P21↓, 5,   P21↑, 71,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 27,   pRB↓, 1,   p‑pRB↓, 1,   RB1↑, 2,   p‑RB1↓, 5,   Securin↓, 1,   TumCCA?, 2,   TumCCA↓, 8,   TumCCA↑, 287,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 1,   ALDH↓, 7,   ALDH1A1↓, 2,   BMI1↓, 1,   CD133↓, 9,   CD24↓, 3,   CEBPA↑, 1,   cFos↓, 7,   CSCs?, 1,   CSCs↓, 51,   Diff↓, 2,   Diff↑, 2,   FGF↓, 2,   Gli↓, 1,   Gli1↓, 6,   HH↓, 3,   HMGCR↓, 1,   IGF-1↓, 5,   p‑IGF-1↓, 1,   IGF-2↓, 1,   IGFBP3↑, 2,   Ki-67↓, 22,   Let-7↑, 3,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 13,   Nestin↓, 3,   NOTCH↓, 13,   NOTCH1↓, 11,   NOTCH1↑, 2,   NOTCH2↑, 1,   NOTCH3↓, 3,   PTCH1↓, 2,   Shh↓, 5,   Smo↓, 4,   TumCG?, 3,   TumCG↓, 139,   TumCG↑, 3,   TumCP↓, 183,   TumCP↑, 4,   tyrosinase↓, 1,   Wnt?, 1,   Wnt↓, 29,   Wnt↑, 1,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

Alix/AIP‑1↓, 1,   AntiAg↓, 1,   AP-1↓, 6,   ASAP2↓, 1,   ATPase↓, 1,   ATPase↑, 1,   AXL↓, 1,   BACH1↓, 1,   CA↓, 1,   Ca+2?, 1,   Ca+2↓, 4,   Ca+2↑, 88,   Ca+2↝, 6,   i-Ca+2?, 1,   i-Ca+2↑, 5,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal1↑, 2,   cal2↑, 3,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Chl↑, 1,   COL1↓, 2,   COL1A1↓, 1,   COL3A1↓, 2,   E-cadherin↓, 4,   E-cadherin↑, 40,   EMT↓, 65,   EMT↑, 2,   EpCAM↓, 2,   F-actin↓, 1,   FAK↓, 12,   p‑FAK↓, 3,   Fibronectin↓, 4,   GIT1↓, 1,   GLI2↓, 2,   ITGB1↓, 1,   ITGB6↓, 1,   KRAS↓, 3,   LAMs↓, 2,   LEF1↓, 2,   LRP1↓, 1,   MALAT1↓, 4,   MET↓, 2,   MMP-10↓, 3,   MMP1↓, 3,   MMP13↓, 3,   MMP15↓, 1,   MMP2↓, 80,   MMP2↑, 1,   proMMP2↓, 1,   MMP3↓, 6,   MMP7↓, 8,   MMP9↓, 84,   MMP9↑, 1,   MMPs↓, 24,   MTA1↓, 1,   MUC4↓, 1,   N-cadherin↓, 23,   PAK1↓, 3,   PAK1↑, 1,   pax↓, 1,   p‑pax↓, 1,   PDGF↓, 3,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 4,   ROCK1↓, 2,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 10,   Smad1↓, 1,   Smad1↑, 1,   SMAD2↓, 1,   SMAD3↓, 3,   SMAD4↓, 2,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 27,   T-cadherin↓, 1,   talin?, 1,   TET1↓, 1,   TET1↑, 2,   TGF-β↓, 14,   TGF-β↑, 2,   TGF-β1↓, 1,   TIMP1↓, 3,   TIMP1↑, 8,   TIMP2↓, 5,   TIMP2↑, 8,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 2,   TumCI?, 1,   TumCI↓, 70,   TumCI↑, 1,   TumCMig↓, 74,   TumCMig↑, 1,   TumMeta↓, 61,   TumMeta↑, 2,   TumPF↓, 1,   Twist↓, 16,   uPA↓, 18,   uPA↝, 1,   uPAR↓, 2,   Vim?, 1,   Vim↓, 34,   Zeb1↓, 12,   Zeb1↑, 1,   ZEB2↓, 1,   α-SMA↓, 2,   α-SMA↑, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 34,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 81,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 6,   EGR1↑, 1,   Endoglin↑, 2,   eNOS↓, 1,   eNOS↑, 1,   HIF-1↓, 5,   Hif1a↓, 57,   Hif1a↑, 2,   LOX1↓, 1,   NO↓, 2,   NO↑, 8,   PHDs↓, 1,   VCAM-1↓, 1,   VEGF↓, 81,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 6,   BBB∅, 2,   CellMemb↓, 1,   CellMemb↑, 6,   CLDN1↓, 4,   CLDN1↑, 1,   CLDN2↓, 2,   EPR↑, 2,   EPR↝, 1,   GLUT1↓, 13,   GLUT2↓, 1,   GLUT3↓, 1,   GLUT4↓, 4,   IBI↑, 1,   memfluid↓, 1,   MMP?, 4,   MMP↓, 695,   MMP↑, 15,   MMP↝, 4,   MMP∅, 4,   MPT↑, 19,   NHE1↓, 2,   OCLN↑, 1,   SMCT1∅, 1,   sonoP↑, 1,   TJ↑, 1,   TRPM7↓, 2,   TRPV1↑, 8,   TRPV1↝, 1,   VGCC↓, 1,   VGSC↓, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD155↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 17,   CD47↓, 2,   CD59↑, 1,   CD8+↑, 6,   cDC2↓, 1,   cGAS–STING↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 61,   COX2/PTGS2↑, 2,   CXCL12↓, 1,   CXCR4↓, 7,   DCells↑, 1,   DR4↑, 9,   DR4∅, 1,   FOXP3↑, 2,   HMGB1↓, 3,   HMGB1↑, 1,   ICAM-1↓, 2,   IFN-γ↓, 4,   IFN-γ↑, 1,   IL1↓, 5,   IL1↑, 1,   IL10↓, 5,   IL12↑, 1,   IL17↓, 1,   IL1β↓, 14,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 2,   IL4↓, 1,   IL4↑, 1,   IL6↓, 37,   IL6↑, 1,   IL8↓, 7,   IL8↑, 1,   Imm↑, 10,   Imm↝, 2,   Inflam↓, 33,   IRAK1↓, 1,   IRAK4↓, 1,   LRIG1↑, 1,   M2 MC↓, 1,   Macrophages↓, 1,   MCP1/CCL2↓, 5,   MCT1↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   Neut↓, 1,   NF-kB↓, 131,   NF-kB↑, 12,   p‑NF-kB↓, 3,   NK cell↑, 4,   NLRP3↓, 3,   p50↓, 1,   p65↓, 10,   p65↑, 1,   p‑p65↓, 1,   p‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 9,   PGE2↓, 17,   PSA↓, 9,   RAGE↓, 1,   RANTES?, 1,   SOCS-3↓, 1,   T-Cell↑, 3,   TCF↓, 3,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 1,   TIGIT↓, 1,   TLR1↑, 1,   TLR4↓, 8,   TNF-α↓, 28,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,   pH↓, 2,   pH↝, 1,   e-pH↑, 1,   i-pH↑, 1,   TAMS↝, 1,   Temp∅, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 2,   AhR↑, 1,   AR↓, 10,   AR↑, 2,   ER-α36↓, 3,   ER-α36↝, 1,   ER(estro)↓, 1,   PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 4,   RANKL↓, 1,   SXR↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 2,   BioAv↓, 35,   BioAv↑, 40,   BioAv↝, 8,   BioEnh↑, 2,   ChemoSen↓, 2,   ChemoSen↑, 157,   ChemoSen⇅, 1,   ChemoSen↝, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 3,   DDS↑, 1,   Dose?, 7,   Dose↓, 3,   Dose↑, 9,   Dose⇅, 2,   Dose↝, 61,   Dose∅, 18,   DrugR↓, 1,   eff↓, 120,   eff↑, 127,   eff↝, 18,   GSTA1↓, 1,   Half-Life↓, 10,   Half-Life↝, 12,   MDR1↓, 7,   MRP1/ABCC1↓, 1,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 20,   P-gp/ABCB1↑, 1,   P-gp/ABCB1∅, 1,   P450↓, 4,   P450↝, 1,   RadioS↑, 49,   RadioS↝, 1,   selectivity?, 1,   selectivity↓, 2,   selectivity↑, 167,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 105,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 4,   ALAT↑, 1,   ALAT∅, 1,   ALP↓, 2,   AR↓, 10,   AR↑, 2,   AST↓, 2,   AST↑, 1,   AST∅, 1,   BMD↑, 1,   BRCA1↓, 3,   p‑BRCA1↑, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 31,   EGFR↑, 1,   p‑EGFR↓, 1,   EZH2↓, 3,   FOXM1↓, 3,   HER2/EBBR2↓, 11,   hTERT/TERT↓, 9,   IL6↓, 37,   IL6↑, 1,   KRAS↓, 3,   LDH↓, 11,   LDH↑, 6,   LDH↝, 1,   e-LDH↑, 1,   i-LDH↓, 1,   Myc↓, 5,   PD-L1↓, 9,   PSA↓, 9,   PSADT↑, 1,   RAGE↓, 1,   TP53↓, 3,   TP53↑, 4,   TRIB3↑, 1,   Tumccf↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 64,   antiNeop↑, 5,   AntiTum↑, 27,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 13,   chemoP↑, 29,   chemoPv↑, 27,   chemoPv⇅, 1,   ChemoSideEff↓, 3,   cognitive↑, 1,   fatigue∅, 1,   hepatoP↑, 11,   hepatoP∅, 1,   K17↓, 1,   neuroP↑, 5,   NP/CIPN↓, 2,   Obesity↓, 2,   OS↑, 14,   OS⇅, 1,   Pain↓, 4,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 1,   QoL↑, 6,   QoL∅, 1,   radioP↑, 5,   Remission↑, 2,   RenoP↑, 8,   Risk↓, 18,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 20,   toxicity↑, 3,   toxicity↝, 6,   toxicity∅, 6,   TumNum↓, 1,   TumVol↓, 23,   TumVol↑, 1,   TumW↓, 9,   Weight↑, 3,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   Bacteria↓, 3,   GutMicro↑, 4,   GutMicro↝, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 4,   Ingr↝, 6,  
Total Targets: 1128

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 7,   antiOx↑, 105,   i-antiOx↑, 1,   ARE↑, 1,   Catalase↓, 1,   Catalase↑, 47,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 25,   GPx1↑, 3,   GPx4↑, 3,   GSH↓, 1,   GSH↑, 41,   GSR↑, 7,   GSTs↓, 1,   GSTs↑, 14,   H2O2↓, 5,   HDL↑, 2,   HO-1↓, 2,   HO-1↑, 25,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 32,   lipid-P↑, 1,   mt-lipid-P↓, 1,   MDA↓, 24,   MDA↑, 2,   MPO↓, 6,   NADH↓, 1,   NQO1↑, 5,   Nrf1↑, 2,   NRF2↑, 51,   p‑NRF2↑, 1,   Prx↑, 2,   RNS↓, 2,   ROS?, 2,   ROS↓, 137,   ROS↑, 12,   ROS⇅, 1,   ROS∅, 8,   mt-ROS?, 1,   mt-ROS↓, 3,   SOD↓, 2,   SOD↑, 53,   SOD1↑, 2,   SOD2↑, 3,   TAC↑, 5,   TBARS↓, 2,   TOS↓, 1,   Trx↑, 2,   Trx1↑, 2,   UCPs↑, 1,   uricA↓, 1,   VitC↑, 2,   VitE↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4,   IronCh↝, 1,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   compIV↑, 2,   DRP1/DNM1L↓, 2,   DRP1/DNM1L↑, 1,   ETC↓, 1,   ETC↑, 1,   ETC↝, 1,   FIS1↓, 1,   Insulin↓, 1,   Insulin↑, 1,   MFN1↓, 1,   MFN2↓, 1,   MFN2↑, 2,   mitResp↓, 1,   mitResp↑, 1,   mtDam↓, 5,   OCR↓, 1,   OCR↑, 3,   OPA1↓, 1,   OXPHOS↓, 2,   OXPHOS↑, 2,   PGC-1α↑, 9,   PGC-1α↝, 1,   PINK1↑, 2,   SIRT3↑, 4,   TFAM↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↑, 1,   ALAT↓, 12,   ALDOA↑, 1,   AMPK↑, 14,   p‑AMPK↑, 2,   ATP↓, 2,   ATP↑, 15,   ATP∅, 1,   BMAL1↑, 1,   cAMP↑, 1,   CRM↑, 1,   cytoP450↓, 1,   DGAT1↓, 1,   ECAR↓, 1,   FASN↓, 1,   glucose↓, 4,   glucose↝, 2,   GlucoseCon↑, 2,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 2,   GPI↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   HK2↑, 2,   KeyT↝, 1,   LDHA↑, 2,   LDL↓, 4,   lipidLev↓, 1,   NADH:NAD↑, 1,   NADPH↓, 2,   PFKL↑, 2,   PFKM↑, 1,   PFKP↑, 1,   PKM1↑, 1,   PKM2↑, 1,   SCFAs↑, 1,   SIRT1↑, 11,   SIRT2↑, 1,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   APAF1↓, 1,   Apoptosis↓, 22,   Apoptosis∅, 1,   mt-Apoptosis↓, 1,   ASC↓, 1,   BAX↓, 12,   BAX↑, 5,   Bax:Bcl2↓, 2,   Bax:Bcl2↑, 2,   Bcl-2↓, 5,   Bcl-2↑, 7,   Bcl-2∅, 1,   Bcl-xL↓, 1,   Casp↓, 1,   Casp1↓, 2,   cl‑Casp1↓, 1,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 18,   Casp3↑, 6,   Casp3∅, 1,   cl‑Casp3↓, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 4,   Casp9↑, 2,   cl‑Casp9↓, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 9,   Cyt‑c↑, 3,   Cyt‑c∅, 3,   Fas↑, 2,   Ferroptosis↓, 3,   GranB/GZMB↓, 1,   GSDMD↓, 1,   iNOS↓, 16,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 3,   p‑p38↓, 1,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 6,   p‑Akt↓, 1,   p‑Akt↑, 2,   CREB↑, 1,   p‑CREB↑, 2,   ERK↑, 4,   p‑ERK↓, 2,   p‑ERK↑, 1,   IκB?, 1,   JNK↓, 1,   JNK↑, 2,   p‑JNK↓, 4,   p‑JNK↑, 1,   MAPK↓, 7,   MAPK↑, 1,   mTOR↓, 3,   mTOR↑, 1,   PI3K↓, 4,   PI3K↑, 4,   p‑PI3K↑, 1,   PTEN↑, 1,   Src↓, 1,   STAT3↓, 1,   STAT3↑, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   ATF2↑, 1,   ATF4↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO↑, 1,   FOXO3↑, 1,   other↓, 2,   other↑, 7,   other↝, 7,   RUNX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 2,   CHOP/DDIT3↓, 3,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 7,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSPs↑, 2,   IRE1↓, 2,   PDI↓, 1,   PERK↓, 1,   p‑PERK↑, 1,   UPR↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B↑, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↓, 3,   p62↑, 4,   PARK2↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   p16↓, 1,   P53↓, 2,   P53↑, 3,   cl‑PARP↓, 1,   cl‑PARP↑, 2,   PARP1↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   P21↓, 3,   P21↑, 3,   RB1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 2,   IGFBP3↑, 1,   neuroG↑, 1,   TumCG↓, 2,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AP-1↓, 2,   Ca+2?, 1,   Ca+2↓, 13,   Ca+2↑, 3,   Ca+2↝, 2,   i-Ca+2↓, 1,   cal2↓, 3,   Cartilage↑, 1,   COL1↑, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 6,   MMP9↑, 1,   MMPs↓, 1,   PAI-1/SERPINE1↓, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 1,   TXNIP↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 4,   E-sel↓, 1,   Hif1a↑, 2,   NO↓, 8,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 14,   BBB↝, 1,   BBB∅, 2,   CellMemb↑, 1,   CLDN5↓, 1,   CLDN5↑, 1,   GastroP↑, 4,   GLUT1↑, 2,   GLUT3↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 1,   MMP↓, 16,   MMP↑, 81,   MMP⇅, 1,   MMP↝, 2,   MMP∅, 4,   MPT↑, 1,   MUC5AC↓, 1,   OCLN↓, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPV1↑, 2,   VGCC↑, 1,   VGCC⇅, 1,   ZO-1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CCL11↓, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 29,   COX2/PTGS2↑, 1,   CXCL12↑, 1,   CXCR4↓, 1,   HMGB1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 3,   IL10↑, 4,   IL12↓, 2,   IL17↓, 3,   IL18↓, 4,   IL1β↓, 21,   IL2↓, 2,   IL22↓, 1,   IL4↓, 3,   IL6↓, 19,   IL6↑, 1,   IL8↓, 1,   Imm↑, 6,   Imm⇅, 1,   Inflam↓, 112,   Inflam↑, 1,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 1,   pol-M2 MC↑, 2,   MCP1/CCL2↓, 3,   MyD88↓, 1,   NeuroI↓, 5,   NF-kB↓, 40,   NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 7,   p65↓, 1,   PAR-2↓, 1,   PGE2↓, 11,   PGE2↑, 1,   TLR1↓, 2,   TLR2↓, 1,   TLR4↓, 3,   TNF-α↓, 29,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   Ach↑, 4,   AChE↓, 20,   AChE↑, 1,   ADAM10↑, 1,   BChE↓, 4,   BDNF↑, 11,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 3,   NGF↑, 2,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 3,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 3,   Aβ↓, 26,   Aβ42↓, 2,   BACE/β-secretase↓, 5,   PSEN1/PS1↓, 1,   tau↓, 4,   p‑tau↓, 6,   XO↓, 1,   XO↝, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   Estro↓, 1,   PPARα↑, 2,   PPARγ↑, 5,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 31,   BioAv↑, 36,   BioAv↝, 15,   CompStab↑, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 2,   Dose⇅, 1,   Dose↝, 21,   Dose∅, 1,   eff↓, 3,   eff↑, 16,   eff↝, 1,   GSTA1↑, 1,   Half-Life↓, 6,   Half-Life↑, 2,   Half-Life↝, 9,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↑, 1,   selectivity↑, 2,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 12,   ALP↓, 3,   AST↓, 14,   BG↓, 2,   BloodF↑, 4,   BMD↑, 3,   BP↓, 4,   BP↝, 1,   BUN↓, 2,   creat↓, 6,   CRP↓, 4,   IL6↓, 19,   IL6↑, 1,   IRes↝, 1,   KeyT↝, 1,   LDH↓, 6,   LDH↑, 1,   NOS2↓, 2,   TC↓, 1,   TG/TAG↓, 1,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 8,   antiAll?, 1,   antiAll↑, 8,   AntiArt↑, 5,   AntiCan↑, 19,   antiD↓, 1,   AntiDiabetic↑, 19,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 5,   ANXi↓, 1,   cardioP↓, 1,   cardioP↑, 35,   chemoP↑, 8,   chemoPv↑, 1,   cognitive↑, 24,   cough?, 1,   hepatoP↑, 31,   Learn↑, 4,   memory↑, 24,   Mood?, 1,   motorD↓, 1,   motorD↑, 9,   Mucositis↓, 1,   neuroP?, 1,   neuroP↓, 2,   neuroP↑, 88,   NP/CIPN↓, 1,   Obesity↓, 10,   OS↑, 2,   Pain↓, 7,   radioP↑, 5,   RenoP↑, 11,   Risk↓, 2,   Sleep↑, 2,   SoreThr?, 1,   Strength↑, 2,   Stress↓, 1,   Stroke↓, 8,   toxicity↓, 40,   toxicity↑, 4,   toxicity↝, 9,   toxicity∅, 7,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 9,   AntiFungal↑, 2,   AntiP↑, 6,   AntiViral↑, 8,   Bacteria↓, 20,   Diar↓, 1,   GutMicro↑, 13,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 2,  
Total Targets: 517

Scientific Paper Hit Count for: MMP, ΔΨm, mitochondrial membrane potential
32 Silver-NanoParticles
26 Quercetin
21 Betulinic acid
21 Capsaicin
18 Baicalein
18 Sulforaphane (mainly Broccoli)
17 Propolis -bee glue
17 Fisetin
16 Curcumin
16 Berberine
16 Magnetic Fields
15 Apigenin (mainly Parsley)
15 Emodin
15 Shikonin
15 Thymoquinone
12 Luteolin
11 Chrysin
11 Resveratrol
10 Ashwagandha(Withaferin A)
10 Phenethyl isothiocyanate
10 Electrical Pulses
10 Gambogic Acid
10 Graviola
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
9 Ivermectin
9 Magnolol
9 Vitamin K2
8 Allicin (mainly Garlic)
8 Cisplatin
8 Dichloroacetate
8 Honokiol
8 Kaempferol
8 Licochalcone A
8 Morin
7 Radiotherapy/Radiation
7 Benzyl isothiocyanate
7 Dandelion Root
7 EGCG (Epigallocatechin Gallate)
7 Juglone
7 Linalool
7 Phenylbutyrate
7 salinomycin
6 chitosan
6 doxorubicin
6 Beta-Caryophyllene
6 Carvacrol
6 Lycopene
6 Magnetic Field Rotating
6 Melatonin
6 Parthenolide
5 Allyl isothiocyanate
5 Alpha-Lipoic-Acid
5 Artemisinin
5 Rosmarinic acid
5 Diindolylmethane
5 Indole-3-carbinol
5 Eugenol
5 Ferulic acid
5 isoorientin
5 Vitexin
5 Selenium NanoParticles
5 Ursolic acid
4 Auranofin
4 Vitamin C (Ascorbic Acid)
4 Metformin
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 chaetocin
4 Selenium
4 Crocetin
4 Copper and Cu NanoParticles
4 Date Fruit Extract
4 Ginkgo biloba-EGb 761
4 Evodiamine
4 Formononetin
4 Gallic acid
4 Garcinol
4 HydroxyTyrosol
4 Hyperoside
4 Isobavachalcone
4 Isorhamnetin
4 Licorice
4 Propyl gallate
4 Taurine
3 SonoDynamic Therapy UltraSound
3 Isovitexin
3 Isothiocyanates
3 Boron
3 Thymol-Thymus vulgaris
3 Carvone
3 Cynaropicrin
3 Diclofenac
3 Ellagic acid
3 Fucoidan
3 Paclitaxel/Taxol
3 Geraniol
3 Gossypol/AT-101
3 Hibiscus sabdariffa
3 isoquercitrin
3 Photodynamic Therapy
3 Matrine
3 Methyl Jasmonate
3 Mangiferin
3 Moringa oleifera
3 Piperlongumine
3 Spermidine
3 Urolithin
2 Astragalus
2 Gemcitabine (Gemzar)
2 5-fluorouracil
2 Anethole/trans-Anethole
2 Baicalin
2 Biochanin A
2 Bufalin/Huachansu
2 Bullatacin
2 Celecoxib
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 Chlorogenic acid
2 Cinnamon
2 Hydroxycinnamic-acid
2 Citric Acid
2 Coenzyme Q10
2 Chlorella (Chlorella vulgaris)
2 Fenbendazole
2 Flaxseed Oil
2 Ginkgo biloba
2 Ginseng
2 γ-linolenic acid (Borage Oil)
2 Gold NanoParticles
2 Hydrogen Gas
2 Hyperthermia
2 Methylene blue
2 Methylsulfonylmethane
2 Mushroom Chaga, Inonotus obliquus
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Nimbolide
2 Patchouli Oil (Pogostemon cablin)
2 Phycocyanin
2 Piperine
2 Plumbagin
2 Psoralidin
2 VitK3,menadione
1 2-DeoxyGlucose
1 Glucose
1 Camptothecin
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Angelica archangelica / Garden Angelica
1 Astaxanthin
1 Atorvastatin
1 Aloe anthraquinones
1 Berbamine
1 D-limonene
1 Cannabidiol
1 Brucea javanica
1 Bromelain
1 Chemotherapy
1 Beetroot
1 Bruteridin(bergamot juice)
1 Black turtle bean
1 buckwheat sprouts
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chocolate
1 Cichoric acid / Chicoric acid
1 Vitamin E
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Dihydrocaffeic Acid
1 Spirulina(Arthrospira/Limnospira)
1 Cyclopamine
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 Mistletoe/Viscum album Extracts
1 Disulfiram
1 Flaxseed/Linseed
1 Shilajit/Fulvic Acid
1 hydroxychloroquine
1 Salvia officinalis
1 Lemon Balm/Melissa officinalis
1 Ginger/6-Shogaol/Gingerol
1 Helleborus niger extracts – Christmas Rose
1 Inositol
1 iodine
1 phytic acid, Inositol hexakisphosphate
1 carboplatin
1 isoflavones
1 itraconazole
1 Geldanamycin
1 Lemongrass Extract/Citral
1 SDG/lignans
1 1,8-Cineole
1 Lutein
1 methylseleninic acid
1 Moringin
1 Methylglyoxal
1 Mushroom Maitake
1 Bicarbonate(Sodium)
1 No Product/Mechanism Only
1 Oleuropein
1 temozolomide
1 Pterostilbene
1 Rauwolfia serpentina/Indian Snakeroot
1 Oxaliplatin
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Sulfasalazine
1 polyethylene glycol
1 Sesamin
1 Lignans
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:197  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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