PI3K Cancer Research Results

PI3K, Phosphatidylinositide-3-Kinases: Click to Expand ⟱
Source: HalifaxProj(inhibit) CGL-CS
Type:
Phosphatidylinositol 3-kinase (PtdIns3K or PI3K) is a family of enzymes that play a crucial role in cell signaling pathways, particularly in the regulation of cell growth, survival, and metabolism. The PI3K pathway is one of the most frequently altered pathways in human cancer. Inhibition of the PI3K pathway has been explored as a therapeutic strategy for cancer treatment. Several PI3K inhibitors have been developed and are currently being tested in clinical trials. These inhibitors can target specific components of the pathway, such as PI3K, AKT, or mTOR.

Class I phosphoinositide 3-kinase (PI3K)
Class III PtdIns3K
In contrast to the class III PtdIns3K as a positive regulator of autophagy, class I PI3K-AKT signaling has an opposing effect on the initiation of autophagy.

PI3K inhibitors include:
-Idelalisib , Copanlisib, Alpelisib
-LY294002?
-Wortmannin: potent PI3K inhibitor, has some associated toxicity.
-Quercetin:
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
Scientific Papers found: Click to Expand⟱
8565- Matr,    Matrine induces apoptosis in acute myeloid leukemia cells by inhibiting the PI3K/Akt/mTOR signaling pathway
- in-vitro, AML, THP1
tumCV↓, p‑PI3K↓, p‑Akt↓, p‑mTOR↓,
8533- Matr,    Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway
- in-vitro, Lung, A549 - in-vitro, Lung, 95D
TumCP?, Apoptosis?, PI3K↓, Akt↓, mTOR↓, IAP1↓,
8542- Matr,    Matrine Suppresses Lung Cancer Progression via Dual Inhibition of CHEK1-Mediated DNA Damage Repair and PI3K/AKT Survival Signaling
- vitro+vivo, Lung, A549
TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, p‑PI3K↓, CHK1↓, p‑Akt↓, Bcl-2↓, MTA1↓, Vim↓, MMP2↓, MMP9↓, γH2AX↑, E-cadherin↑, BAX↑, cl‑Casp3↑, Ki-67↓, TumCG↓,
8534- Matr,    Matrine induces apoptosis and autophagy in human lung adenocarcinoma cells via upregulation of Cavin3 and suppression of PI3K/AKT pathway
- in-vitro, Lung, A549 - in-vitro, Nor, MRC-5
TumCP↓, selectivity↑, Apoptosis↑, BAX↑, Bcl-2↓, TumAuto?, LC3II↑, Beclin-1/ATG6↑, p62↓, Cavin3↓, p‑PI3K↓, p‑Akt↓,
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
8544- Matr,    Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential
- Review, BC, NA
*hepatoP↑, *Inflam↓, *ROS↓, *ER Stress↓, *lipid-P↓, TumCP↓, TumCI↓, TumCMig↓, TumAuto↑, Apoptosis↑, *AST↓, *ALAT↓, *SOD↑, *MDA↓, *TNF-α↓, *IL6↓, *NRF2↑, *HO-1?, *NF-kB↓, *Inflam↓, AFP?, PCNA↓, cMyc↓, Bcl-2↓, BAX↑, EMT↓, MDM2↓, P53↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, NOTCH↑, ChemoSen↑, eff↑, survivin↓, XIAP↓, Synergy↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8555- Matr,    Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
- Review, Var, NA
*AntiTum↑, *Inflam↓, *Analgesic↑, *AntiViral↑, *Imm↑, *PI3K↑, *Akt↑, *mTOR↑, TumAuto↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, E-cadherin↑, Vim↓, MMP2↓, MMP9↓, Snail↓, Slug↓, PTEN↑, TumCP↓, TumCMig↓, TumCI↓, ChemoSen↑, ROS↑, uPA↓, p‑ERK↓, cachexia↓, antiD↑, GSK‐3β↓, LC3B-II↑, p62↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, FOXO1↑, FOXO3↑, FOXO4↑, PARP↑, BIM↑, Bcl-2↓, survivin↓, miR-21↓, *HOTAIR↑, *p‑Akt↑, *p‑STAT3↑, *STAT3↑, *ROS↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, JAG1↓, HES1↓, BioAv↝, toxicity↝,
8553- Matr,    Research progress on the pharmacological effects of matrine
- Review, Nor, NA
*AntiCan↑, *antiAll↑, *Stroke↓, TumCI↓, TumCMig↓, TumCP↓, TumCCA↑, *AGEs↓, *Inflam↓, *antiOx↑, *neuroP↑, *Apoptosis↓, *IBI↑, *GutMicro↑, EGFR↓, *HSP60/HSPD1↓, *antiOx↑, *GSH↑, *Catalase↑, *AChE↓, *BChE↓, *neuroP↑, *PI3K↑, *Akt↑, *mTOR↑, *cognitive↑, *ROS↓, *toxicity↑,
8547- Matr,    Matrine in cancer therapy: antitumor mechanisms and nano-delivery strategies
- Review, Var, NA
*Ingr↝, *AntiTum↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, TumCMig↓, TumCI↓, JPT1/HN1↓, Erlin1↑, LINC01116↓, miR-592↑, ERK↓, JAK↓, STAT3↓, miR-182-5p↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, Sharpin↓, ROS↓, AMPK↑, mTOR↓, Snail↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, E-cadherin↑, PTEN↑, miR-10b-5p↓, GPx4↓, lipid-P↑, Iron↑, Piezo1↑,
8543- Matr,    Mechanism of matrine inhibiting retinoblastoma cell growth by downregulating NR1D2 to regulate phosphorylation of the PI3K/AKT signaling pathway
- in-vitro, RPE/RB, Y79
TumCMig↓, Apoptosis↑, NR1D2↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑PI3K↓, p‑Akt↓,
7824- MBS,  IVT,  VT,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA - Review, Stroke, NA - Review, Park, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *ROS↓, *Inflam↓, *AChE↓, *BBB↑, *memory↑, *hepatoP↑, *Imm↑, *hyperG↓, *AntiCan↑, *eff↑, *Stroke↓, *BACE/β-secretase↓, *PI3K↓, *Akt↓, *mTOR↓, *Dose↓,
8644- MBZ,    The Novel IGF-1R Inhibitor PB-020 Acts Synergistically with Anti-PD-1 and Mebendazole against Colorectal Cancer
- vitro+vivo, CRC, HT-29 - in-vitro, CRC, HCT116 - in-vitro, CRC, LoVo - in-vitro, CRC, SW-620
Synergy↑, tumCV↓, PI3K?, Akt?,
8711- MET,    https://pubmed.ncbi.nlm.nih.gov/42725610/
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, OCR↑, Hypoxia↓, RadioS↑, ChemoSen↑,
2375- MET,    Metformin inhibits gastric cancer via the inhibition of HIF1α/PKM2 signaling
- in-vitro, GC, SGC-7901
tumCV↓, TumCI↓, TumCMig↓, Apoptosis↑, PARP↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, COX2/PTGS2↓,
3457- MF,    Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
- Review, Var, NA
Apoptosis↑, H2O2↑, ROS↑, RadioS↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,
496- MF,    Low-Frequency Magnetic Fields (LF-MFs) Inhibit Proliferation by Triggering Apoptosis and Altering Cell Cycle Distribution in Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, ZR-75-1 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
ROS↑, PI3K↓, Akt↓, GSK‐3β↑, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, CycB/CCNB1↓, TumCCA↑, p‑Akt↓, TumCP↓, selectivity↑, eff↓,
486- MF,    mTOR Activation by PI3K/Akt and ERK Signaling in Short ELF-EMF Exposed Human Keratinocytes
- in-vitro, Nor, HaCaT
*mTOR↑, *PI3K↑, *Akt↑, *p‑ERK↑, *other↑, *p‑JNK↑, *p‑P70S6K↑,
3488- MFrot,  MF,    Rotating magnetic field improves cognitive and memory impairments in APP/PS1 mice by activating autophagy and inhibiting the PI3K/AKT/mTOR signaling pathway
- in-vivo, AD, NA
*cognitive↑, *memory↑, *neuroP↑, *Aβ↓, *PI3K↓, *Akt↓, *mTOR↓,
8471- Mg,    Magnesium protects cognitive functions and synaptic plasticity in streptozotocin-induced sporadic Alzheimer's model
- in-vivo, AD, NA
*Learn?, *memory?, *p‑tau↓, *GSK‐3β↑, *Akt↑, *PI3K↑, *cognitive↑,
8659- MLT,  Cisplatin,    Melatonin Sensitizes OVCAR-3 Cells to Cisplatin through Suppression of PI3K/Akt Pathway
- in-vitro, Ovarian, OVCAR-3
Dose?, ROS↑, cl‑Casp3↑, p‑Akt↓, ChemoSen↑, Apoptosis↑, PI3K↓, Akt↓,
8661- MLT,    Melatonin effect on breast and ovarian cancers by targeting the PI3K/Akt/mTOR pathway
- in-vitro, BC, NA - in-vitro, Ovarian, NA
PTEN↓, PI3K↓, Akt↓, mTOR↓, mTORC1↓, MDM2↓, BAD↑, Bcl-xL↑, P53↓, TumAuto↑, ULK1/ATG1↑, p‑Beclin-1/ATG6↑,
8690- MLT,    Melatonin inhibits proliferation, migration, and invasion by inducing ROS-mediated apoptosis via suppression of the PI3K/Akt/mTOR signaling pathway in gallbladder cancer cells
- vitro+vivo, Gall, NOZ
TumCG↓, TumCMig↓, TumCI↓, ROS↑, PI3K↓, Akt↓, mTOR↓, eff↓, TumCG↓, tumCV↓,
8687- MLT,    Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3
TumCP↓, TumCCA↑, Hif1a↓, NF-kB↓, Bcl-2↓, ROS↑, Akt↓, PCNA↓, cycD1/CCND1↓, BAX↓, Apoptosis?, ChemoSen↑, Wnt↓, β-catenin/ZEB1↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PI3K↓, Akt↓, P53↑, P21↑, *cardioP?, *NRF2↑, *HO-1↑, *RenoP↑, chemoP↑,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
8683- MLT,    Intra-tumor ROS amplification by melatonin interferes in the apoptosis-autophagy-inflammation-EMT collusion in the breast tumor microenvironment
- in-vivo, BC, NA
ROS↑, SIRT1↑, IL6↓, STAT3↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, TumCP↓, tumCV↓, JNK↑, P53↑, Bax:Bcl2↑, cl‑Casp3↑, Apoptosis↑, eff∅, TumAuto↑, EMT↓, Half-Life↓, CompStab↓, BioAv↓, Dose↝, TumW↓, TumVol↓, Ki-67↓, PTEN↑,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
8915- MO,    Therapeutic Potential of Moringa oleifera in Alzheimer’s Disease: A Review of Neuroprotective Mechanisms
- Review, AD, NA
*Ingr↝, *antiOx↑, *Inflam↓, *NRF2↑, *ARE↑, *AChE↓, *Aβ42↓, *cognitive↑, *BACE/β-secretase↓, *neuroP↑, *PI3K↑, *Akt↑, *mTOR↑, *Learn↑, *memory↑, *ATP↑, *SOD↑, *Catalase↑, *p‑tau↓,
8898- MOR,    Molecular mechanism of anti-cancerous potential of Morin extracted from mulberry in Hela cells
- in-vitro, Cerv, HeLa
TumCP↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, WEE1↑, CDK1↓, CDC25↓, survivin↓, CycB/CCNB1↓, Chk2↓, BAX↑, BAD↑, Cyt‑c↑, APAF1↑, Casp9↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, FasL↑, FADD↑, Casp10↑, PARP↑, PI3K↑, Akt↑, mTOR↑, p70S6↑, Diablo↑, Bcl-2↓, Bcl-xL↓, AMPK↓, IAP1↓, NF-kB↓, ROS↑,
8868- MOR,  PacT,    Synergistic effect of morin and paclitaxel impedes cell proliferation through PI3K/AKT/STAT3 signaling axis inhibition in gastric cancer
- in-vitro, GC, HGC27
ChemoSen↑, ROS↑, MMP↓, Apoptosis↑, cFos↓, KRAS↓, p‑ERK↓, PI3K↓, Akt↓, STAT3↓, TumCP↓,
8879- MOR,  doxoR,    Synergistic Effects of Morin and Doxorubicin Overcome Chemoresistance in Ovarian Cancer: Preclinical Insights From in vitro and in vivo Models
- vitro+vivo, Ovarian, OVCAR-3 - NA, Melanoma, A2780S
Dose↝, ChemoSen↑, cycA1/CCNA1↓, cycD1/CCND1↓, TumVol↓, Apoptosis↑, TumCCA↑, ROS↝, chemoP↑, TumAuto↑, ROS↓, SOD↑, Catalase↑, GSH↑, MDA↓, cardioP↑, mTOR↓, PI3K↓, Akt↓, Bcl-2↓, Casp3↑, Casp9↑, LC3A↑, ATG5↑, Beclin-1/ATG6↑,
8944- MushCha,    Inonotus obliquus-derived polysaccharide inhibits the migration and invasion of human non-small cell lung carcinoma cells via suppression of MMP-2 and MMP-9
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑MAPK↓, p‑PI3K↓, p‑Akt↓, COX2/PTGS2↓, NF-kB↓,
8960- mushLions,    Recent Advances in Erinacine A: Preparation, Biological Activities, and Biosynthetic Pathway
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *NGF↑, *other↝, *antiOx↑, *Inflam↓, *antiCG↑, *Bacteria↓, *hyperG↝, *AntiDiabetic↑, *AntiCan↑, *neuroG↑, *cognitive↑, *Stroke↓, *IL1β↓, *IL6↓, *TNF-α↓, *RNS↓, *iNOS↓, *MAPK↓, *CHOP/DDIT3↓, TumCD↓, ROS↑, TumCP↓, TumCI↓, ROCK1↓, LIMK2↓, Cofilin↓, PI3K↓, mTOR↓, P70S6K↓, TumCMig↓, TumMeta↓, TGF-β↓, MMP9↓, *AntiAge↑, *RIP1↓, *cl‑Casp8↓, *cl‑Casp3↓, *NRF2↑, *HO-1↑, *SOD1↑,
8954- mushLions,    Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis
- in-vitro, GC, SGC-7901
TumCP↓, Tumccf↓, Apoptosis↑, TumCCA↑, Bcl-2↓, PI3K↓, Akt↓, Casp8↑, Casp3↑, P53↑, CDK4↑, BAX↑, BAD↑, ROS↑,
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, Var, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2/PTGS2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,
1128- Myr,    Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer
- vitro+vivo, Ovarian, NA
MAPK↓, ERK↓, PI3K↓, Akt↓, p‑PARP↑, cl‑Casp3↑, Bax:Bcl2↑, TumCMig↓, SMAD3↓,
1799- NarG,    Naringenin as potent anticancer phytocompound in breast carcinoma: from mechanistic approach to nanoformulations based therapeutics
- Review, BC, NA
TumCCA↑, BioAv↑, Half-Life∅, TNF-α↓, Casp8↑, BAX↑, Bak↑, EGF↓, mTOR↓, PI3K↓, ERK↓, Akt↓, NF-kB↓, VEGF↓, angioG↓, antiOx↑, EMT↓, OS↑, MAPK↓, ChemoSen↑, MMP9↓, MMP2↓, ROS↑, ROS↑, GSH↓, Casp3↑, ROS↑,
1801- NarG,    A Narrative Review on Naringin and Naringenin as a Possible Bioenhancer in Various Drug-Delivery Formulations
- Review, Var, NA
AntiCan↓, CYP19↓, PI3K↓, Akt↓, TumAuto↑, Synergy↑, BioEnh↑,
1803- NarG,    Naringin and naringenin as anticancer agents and adjuvants in cancer combination therapy: Efficacy and molecular mechanisms of action, a comprehensive narrative review
- Review, Var, NA
JAK↓, STAT↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, COX2/PTGS2↓, NOTCH↓, TumCCA↑,
1805- NarG,    Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota
- in-vitro, Ovarian, A2780S - in-vivo, NA, NA
TumCP↓, TumCMig↓, PI3K↓, TumVol↓, TumW↓, BioAv↑, GutMicro↑, Dose∅, eff↑, EGFR↓, cycD1/CCND1↓, toxicity∅,
6775- Neem,  Nimb,    Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment
- Review, Nor, NA
*antiOx↑, P53↑, PTEN↑, NF-kB↓, PI3K↓, Akt↓, Bcl-2↓, VEGF↓, *Inflam↓, *COX2/PTGS2↓, *5LO↝, *Wound Healing↑, *Imm↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, *AntiViral↑, *Bacteria↑, *AntiBio↑, *AntiFungal↑, cMyc↓, BAX↓, IAP1↓, IAP2/BIRC3↓, Bcl-xL↓, survivin↓, XIAP↓, angioG↓,
6490- Nimb,    Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer
- in-vitro, Oral, SCC4
PI3K↓, Akt↓, GSK‐3β↑, MMP↓, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, TumAuto↑, Beclin-1/ATG6↓, p62↑, PI3K↓, chemoPv↑,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
4972- Nimb,    Chemopreventive and therapeutic effects of nimbolide in cancer: The underlying mechanisms
- Review, Var, NA
Apoptosis↑, TumCP↓, NF-kB↓, Wnt↓, PI3K↓, MAPK↓, JAK↓, STAT↓,
4977- Nimb,    Nimbolide Inhibits SOD2 to Control Pancreatic Ductal Adenocarcinoma Growth and Metastasis
- vitro+vivo, PC, AsPC-1 - in-vitro, PC, PANC1
SOD2↑, TumCG↓, TumMeta↓, ROS↑, Apoptosis↑, PI3K↓, Akt↓, EMT↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, Bcl-2↓,
3257- PBG,    The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
- Review, Var, NA
CDK4↓, CDK6↓, pRB↓, ROS↓, TumCCA↑, P21↑, PI3K↓, Akt↓, EMT↓, E-cadherin↑, Vim↓, *COX2/PTGS2↓, *MPO↓, *MDA↓, *TNF-α↓, *IL6↓, *Catalase↑, *SOD↑, *AST↓, *ALAT↓, *IL1β↓, *IL10↓, *GPx↓, *TLR4↓, *Sepsis↓, *IFN-γ↑, *GSH↑, *NRF2↑, *α-SMA↓, *TGF-β↓, *IL5↓, *IL6↓, *IL8↓, *PGE2↓, *NF-kB↓, *MMP9↓,
1678- PBG,  5-FU,  sericin,    In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway
- in-vitro, CRC, Caco-2 - in-vivo, NA, NA
PI3K↓, Akt↓, mTOR↓, TumCP↓, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, ROS↓, FOXO1↑, *toxicity∅, eff↑,
1661- PBG,    Propolis: a natural compound with potential as an adjuvant in cancer therapy - a review of signaling pathways
- Review, Var, NA
JNK↓, ERK↓, Akt↓, NF-kB↓, FAK↓, MAPK↓, PI3K↓, Akt↓, P21↑, p27/CDKN1B↑, TRAIL↑, BAX↑, P53↑, ERK↓, ChemoSen↑, RadioS↑, Glycolysis↓, HK2↓, PKM2↓, LDHA↓, PFK↓,
4920- PEITC,  Cisplatin,    PEITC restores chemosensitivity in cisplatin-resistant non-small cell lung cancer by targeting c-Myc/miR-424-5p
- vitro+vivo, NSCLC, A549
TumCG↓, ChemoSen↑, cMyc↓, PI3K↓, Akt↓, mTOR↓, BioAv↝, tumCV↓, ChemoSen↑,

Showing Research Papers: 401 to 450 of 562
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 562

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA⇅, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 11,   antiOx⇅, 1,   Catalase↓, 9,   Catalase↑, 2,   Copper↓, 1,   GPx↓, 2,   GPx↑, 1,   GPx4↓, 8,   GSH↓, 21,   GSH↑, 6,   GSH/GSSG↓, 1,   GSR↓, 2,   GSTs↓, 2,   GSTs↑, 2,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 7,   HO-1↑, 14,   hyperG↓, 1,   Iron↑, 2,   i-Iron↑, 1,   c-Iron↑, 1,   Keap1↓, 1,   Keap1↝, 1,   lipid-P↓, 4,   lipid-P↑, 10,   MDA↓, 3,   MDA↑, 8,   MPO↓, 1,   NQO1↓, 2,   NQO1↑, 1,   NRF2↓, 18,   NRF2↑, 16,   NRF2↝, 3,   OSI↑, 1,   PYCR1↓, 2,   RNS↑, 1,   ROS?, 1,   ROS↓, 23,   ROS↑, 213,   ROS⇅, 10,   ROS↝, 4,   i-ROS↓, 1,   mt-ROS↑, 3,   SOD↓, 12,   SOD↑, 6,   SOD1↓, 1,   SOD2↓, 4,   SOD2↑, 2,   TAC↓, 1,   TBARS↑, 1,   Thiols↓, 1,   TKT↝, 1,   TOS↑, 1,   Trx↓, 2,   Trx1↑, 1,   ox-Trx1↑, 1,   TrxR↓, 7,   TrxR1↓, 3,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,   IronCh∅, 1,   STEAP3↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 7,   CDC25↓, 8,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 9,   ETC↓, 3,   HSP60/HSPD1↓, 2,   Insulin↓, 1,   mitResp↓, 2,   mitResp↑, 1,   MKK7↓, 1,   mtDam↑, 17,   OCR↓, 4,   OCR↑, 3,   OXPHOS↓, 2,   OXPHOS↑, 1,   OXPHOS↝, 1,   PDH↓, 1,   PDH↑, 2,   PDH↝, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SIRT3↓, 2,   SIRT3↑, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 7,   AApath↓, 1,   ACC↓, 2,   ACC↑, 1,   ACLY↓, 3,   ACSL4↑, 1,   adiP↑, 1,   ALAT↓, 4,   ALDOA↓, 1,   AminoA↓, 1,   AMPK?, 1,   AMPK↓, 2,   AMPK↑, 27,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 23,   mt-ATP↓, 1,   ATP:AMP↓, 1,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   ECAR↓, 1,   ENO1↓, 2,   p‑ENO1↓, 1,   FABP4↓, 1,   FABP4↑, 1,   FASN↓, 5,   FASN↑, 1,   FBPase↑, 1,   G6PD↓, 2,   GAPDH↓, 1,   GLS↓, 1,   glucoNG↑, 1,   glucose↓, 3,   glucose↝, 1,   GlucoseCon↓, 12,   GlucoseCon↑, 2,   GlutaM↓, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 40,   Glycolysis↑, 1,   p‑GS3Kβ↓, 1,   GSK‐3β↓, 13,   GSK‐3β↑, 10,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 11,   p‑GSK‐3β↑, 1,   H2S↑, 1,   HK1↓, 1,   HK2↓, 18,   HK2↑, 1,   lactateProd↓, 11,   lactateProd↑, 2,   LDHA↓, 9,   LDHA↑, 1,   LDL↓, 2,   lipoGen↓, 1,   MCT4↓, 1,   NADPH↓, 2,   NADPH↑, 2,   O-Glc↓, 1,   PA↑, 1,   PDK1 / PDPK1↓, 8,   PDK3↑, 1,   PFK↓, 3,   PFK1↓, 5,   PFK2↓, 2,   PKM2↓, 21,   PKM2↑, 1,   PPP↓, 1,   R5P↝, 1,   RARα↓, 1,   RARβ↑, 1,   RARγ↑, 1,   p‑S6↓, 1,   SCD1↓, 2,   SIRT1↓, 6,   SIRT1↑, 11,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 2,   TCA↑, 1,   TS↓, 1,   Warburg↓, 11,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 8,   Apoptosis?, 4,   Apoptosis↓, 7,   Apoptosis↑, 246,   Apoptosis↝, 1,   mt-Apoptosis↑, 6,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 4,   BAD↑, 17,   Bak↑, 7,   BAX↓, 4,   BAX↑, 137,   BAX↝, 1,   Bax:Bcl2↑, 26,   Bcl-2↓, 137,   Bcl-2↑, 3,   Bcl-2↝, 1,   Bcl-2∅, 1,   Bcl-xL↓, 28,   Bcl-xL↑, 1,   Bcl-xL↝, 1,   BID↓, 2,   BID↑, 7,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 7,   BNIP3↑, 3,   BNIP3↝, 1,   BOK↑, 1,   Casp↓, 2,   Casp↑, 30,   cl‑Casp↑, 2,   Casp1↓, 2,   Casp1↑, 1,   cl‑Casp1↑, 1,   Casp10↑, 3,   Casp12↑, 2,   cl‑Casp12↑, 1,   Casp2↑, 2,   Casp3↓, 2,   Casp3↑, 133,   Casp3↝, 1,   Casp3∅, 1,   cl‑Casp3↑, 33,   proCasp3↑, 3,   Casp6↑, 1,   Casp7↑, 13,   cl‑Casp7↑, 4,   Casp8↓, 1,   Casp8↑, 31,   Casp8∅, 1,   cl‑Casp8↑, 5,   proCasp8↑, 3,   pro‑Casp8↑, 1,   Casp9↑, 79,   p‑Casp9↑, 1,   cl‑Casp9↑, 13,   proCasp9↓, 1,   proCasp9↑, 2,   cFLIP↓, 6,   Cyt‑c↓, 1,   Cyt‑c↑, 78,   Cyt‑c↝, 1,   mt-Cyt‑c↓, 1,   Diablo↑, 7,   DR5↓, 1,   DR5↑, 32,   Endon↑, 2,   FADD↑, 4,   Fap1↓, 2,   Fas↓, 1,   Fas↑, 21,   FasL↓, 1,   FasL↑, 7,   Ferroptosis↑, 13,   GRP58↓, 1,   GSDMD↑, 1,   cl‑GSDMD↑, 1,   GSDME↑, 1,   IAP1↓, 10,   IAP2/BIRC3↓, 5,   IAP2/BIRC3↑, 1,   ICD↑, 1,   iNOS↓, 14,   Mcl-1?, 1,   Mcl-1↓, 26,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 11,   MDM2↑, 1,   p‑MDM2↓, 1,   MLKL↑, 1,   MOMP↑, 1,   NAIP↓, 1,   Necroptosis↑, 4,   necrosis↑, 2,   NOXA↑, 2,   oncosis↑, 1,   p38↓, 8,   p38↑, 23,   p‑p38↓, 1,   p‑p38↑, 4,   Paraptosis↑, 1,   PUMA↓, 2,   PUMA↑, 4,   Pyro↑, 4,   RIP1↓, 2,   RIP1↑, 1,   p‑RIP1↑, 1,   RIP3↓, 1,   RIP3↑, 1,   survivin↓, 46,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAILR↑, 2,   TumCD↓, 1,   TumCD↑, 15,   XIAP↓, 27,   XIAP↑, 1,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 2,   Akt↓, 363,   Akt↑, 13,   Akt↝, 4,   p‑Akt↓, 91,   p‑Akt↑, 3,   AKT1↓, 5,   Akt2↓, 2,   AMPKα↑, 2,   Cavin3↓, 1,   CIP2A↓, 2,   CK2↓, 5,   cMET↓, 4,   p‑cMET↑, 1,   cSrc↓, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 48,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 6,   ERK↓, 67,   ERK↑, 9,   ERK↝, 1,   p‑ERK↓, 16,   p‑ERK↑, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FGFR4/CD334↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 14,   HGF/c-Met↓, 3,   Hippo↝, 1,   IGF-1R↓, 9,   IGFR↓, 1,   IKKα↓, 6,   IKKα↑, 2,   p‑IKKα↓, 2,   ILK↓, 1,   IP6K1↓, 1,   IκB↓, 1,   IκB↑, 2,   p‑IκB↓, 2,   JAK↓, 10,   JAK1↓, 1,   JAK1↑, 1,   JAK2↓, 11,   JNK↓, 10,   JNK↑, 25,   JNK↝, 2,   p‑JNK↓, 1,   p‑JNK↑, 4,   LIMK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 61,   MAPK↑, 17,   MAPK↝, 2,   p‑MAPK↓, 2,   p‑MAPK↑, 1,   MARK4↓, 2,   MEK↓, 11,   MEK↑, 1,   MKK4↓, 2,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 175,   mTOR↑, 3,   mTOR↝, 2,   p‑mTOR↓, 20,   mTORC2↓, 3,   mTORC2↑, 2,   p70S6↓, 2,   p70S6↑, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 8,   p‑P70S6K↓, 3,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFRA↓, 1,   PI3K?, 1,   PI3K↓, 422,   PI3K↑, 14,   PI3K↝, 6,   p‑PI3K↓, 46,   p‑PI3K↑, 1,   PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 3,   PKCδ↓, 11,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 5,   PTEN↑, 38,   PTEN↝, 1,   Raf↓, 7,   c-Raf↓, 1,   RAS↓, 14,   RET↓, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 5,   Src↓, 3,   Src↑, 1,   p‑Src↓, 1,   STAT↓, 10,   p‑STAT↓, 1,   STAT3↓, 67,   STAT3↑, 3,   p‑STAT3↓, 13,   p‑STAT3↑, 2,   STAT5↓, 2,   STAT6↓, 3,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TSC2↑, 4,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 7,   CBP↓, 3,   cJun↓, 8,   cJun↑, 3,   p‑cJun↑, 1,   cMyc↓, 36,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 10,   DNMT3A↓, 3,   DNMT3B↓, 1,   DNMTs↓, 5,   EZH2↓, 7,   FOXM1↓, 5,   FOXO↑, 2,   FOXO1↓, 4,   FOXO1↑, 3,   FOXO3↓, 3,   FOXO3↑, 8,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 2,   FOXO4↑, 1,   H3↓, 1,   H3↑, 1,   ac‑H3↑, 1,   H3K4↓, 1,   H4↓, 1,   H4↑, 2,   ac‑H4↑, 1,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 14,   HDAC1↓, 7,   HDAC10↓, 1,   HDAC10↑, 1,   HDAC2↓, 5,   HDAC3↓, 4,   HDAC4↓, 2,   HDAC8↓, 3,   HES1↓, 3,   JPT1/HN1↓, 1,   KLF2↓, 1,   KLF5↓, 1,   LINC01116↓, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-122-5p↑, 1,   miR-124-3p↓, 1,   miR-125b↝, 1,   miR-126↑, 2,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-149↑, 1,   miR-155↓, 4,   miR-182-5p↓, 1,   miR-195↑, 1,   miR-199↑, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-206↑, 1,   miR-21↓, 8,   miR-21↑, 2,   miR-218↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-224↓, 2,   miR-29b↑, 2,   miR-326-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 2,   miR-34a↓, 2,   miR-34a↑, 8,   miR-34b-5p↑, 2,   miR-384↑, 2,   miR-422a↑, 2,   miR-429↑, 1,   miR-592↑, 1,   MTA2↓, 2,   Myc↓, 4,   MYCN↓, 1,   n-MYC↓, 1,   NR1D2↓, 1,   OCT4↓, 12,   other?, 1,   other↓, 4,   other↑, 2,   other↝, 10,   PAX2↓, 1,   PCAF↓, 2,   PhotoS↑, 1,   SOX2↓, 7,   SOX4↓, 5,   SUV39H↓, 1,   TCF-4↓, 1,   TFAP2A↓, 1,   tumCV?, 2,   tumCV↓, 62,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 18,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 3,   eIF2α↑, 5,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 37,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 9,   HSP27↓, 4,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 16,   HSP90↑, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↑, 2,   PERK↑, 6,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↑, 6,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↓, 1,   ATG3↑, 3,   ATG5↑, 9,   ATG7↑, 5,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 22,   p‑Beclin-1/ATG6↑, 1,   CTSB↓, 2,   CTSD↓, 2,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 4,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 2,   LC3B-II↑, 3,   LC3I↓, 1,   LC3II↓, 1,   LC3II↑, 17,   p62↓, 7,   p62↑, 5,   PARK2↑, 1,   RUBCN↓, 1,   SESN2↑, 2,   TumAuto?, 1,   TumAuto↓, 3,   TumAuto↑, 58,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   BRCA1↝, 1,   p‑BRCA1↑, 1,   DFF45↓, 1,   DFF45↑, 2,   DNAdam↑, 49,   DNArepair↓, 2,   DNArepair↑, 1,   ERCC3↑, 1,   FEN1↓, 1,   HR↓, 1,   hTERT/TERT↓, 11,   p16↑, 3,   P53?, 1,   P53↓, 5,   P53↑, 89,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 3,   p73↑, 1,   PARP↓, 4,   PARP↑, 23,   p‑PARP↑, 2,   cl‑PARP↑, 66,   PARP1↑, 2,   cl‑PARP1↑, 1,   PCNA↓, 28,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 3,   Telomerase↓, 10,   TOP1↓, 4,   TOP2↓, 2,   TOP2↑, 1,   TP53↑, 2,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↑, 6,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 17,   CDK1↑, 2,   CDK2↓, 37,   CDK2↑, 4,   CDK4↓, 45,   CDK4↑, 5,   p‑CDK4↓, 1,   CDK4/6↓, 2,   CDK6↓, 18,   CDK6↑, 4,   CDK7↓, 1,   CDK8↓, 1,   CDKN1C/p57↓, 1,   CHK1↓, 2,   p‑CHK1↑, 2,   Chk2↓, 1,   p‑Chk2↑, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 11,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 26,   CycB/CCNB1↑, 5,   cycD1/CCND1↓, 78,   cycD1/CCND1↑, 3,   cycD1/CCND1↝, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 17,   cycE/CCNE↑, 1,   cycE1↓, 1,   E2Fs↓, 4,   Ki-67↓, 34,   MAD↓, 1,   mitA↑, 1,   P21?, 1,   P21↓, 4,   P21↑, 55,   P21↝, 1,   p27/CDKN1B↓, 6,   p27/CDKN1B↑, 29,   pRB↓, 4,   p‑pRB↓, 4,   p‑RB1↓, 1,   Securin↓, 1,   TumCCA↓, 5,   TumCCA↑, 196,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   ALDH↓, 6,   ALDH1A1↓, 3,   AXIN1↑, 2,   Axin2↑, 1,   BMP2↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 2,   CD133↓, 8,   CD133↑, 1,   CD34↓, 2,   cFos↓, 7,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 36,   Diff↓, 2,   Diff↑, 3,   EIF4E↓, 2,   EP2↓, 1,   EP4/PTGER4↓, 1,   FGF↓, 3,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 6,   HH↓, 7,   IGF-1↓, 17,   p‑IGF-1↓, 1,   IGF-2↓, 2,   IGFBP1↑, 1,   IGFBP3↓, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 34,   Let-7↓, 1,   Let-7↑, 4,   mTORC1↓, 11,   p‑mTORC1↓, 1,   Nanog↓, 10,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 21,   NOTCH↑, 1,   NOTCH1↓, 16,   NOTCH1↑, 2,   NOTCH3↓, 3,   OGFr↑, 2,   p300↓, 4,   Piezo1↑, 1,   Shh↓, 7,   Smo↓, 3,   TAZ↓, 1,   TumCG?, 1,   TumCG↓, 82,   TumCG↑, 3,   TumCP?, 2,   TumCP↓, 181,   TumCP↑, 3,   tyrosinase↓, 2,   Wnt?, 1,   Wnt↓, 61,   Wnt↑, 1,   Wnt↝, 1,   Wnt/(β-catenin)↓, 7,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AEG1↑, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 14,   AP-1↝, 1,   ASAP2↓, 1,   ATPase↓, 1,   AXL↓, 3,   BACH1↓, 1,   CA↓, 1,   Ca+2↓, 3,   Ca+2↑, 25,   Ca+2↝, 1,   i-Ca+2?, 1,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Chl↓, 1,   Cofilin↓, 3,   p‑Cofilin↑, 2,   COL1↓, 2,   COL3A1↓, 1,   COL4↓, 1,   DLC1↑, 1,   E-cadherin↓, 12,   E-cadherin↑, 49,   EM↑, 1,   EMT↓, 104,   EMT↝, 1,   EpCAM↓, 2,   F-actin↓, 3,   FAK↓, 20,   FAK↑, 1,   p‑FAK↓, 2,   fascin↓, 1,   Fibronectin↓, 4,   Furin↓, 1,   GIT1↓, 1,   GLI2↓, 4,   GLI3↑, 1,   IQGAP3↓, 1,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   KRAS↓, 2,   LAMs↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MET↓, 3,   p‑MET↓, 1,   MMP-10↓, 3,   MMP1↓, 6,   MMP13↓, 2,   MMP15↓, 1,   MMP16↓, 3,   MMP2↓, 102,   MMP2↝, 1,   MMP3↓, 11,   MMP7↓, 11,   MMP9↓, 112,   MMP9↑, 2,   MMPs↓, 36,   MTA1↓, 1,   MUC4↓, 2,   N-cadherin↓, 38,   NCAM↑, 1,   NEDD9↓, 1,   PAK1↓, 1,   PDGF↓, 6,   Rac1↓, 3,   RECK↑, 1,   Rho↓, 3,   Rho↑, 2,   ROCK1↓, 6,   ROCK1↑, 2,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 15,   Smad1↓, 1,   Smad1↝, 1,   SMAD2↓, 2,   SMAD3↓, 4,   SMAD4↓, 2,   Snail?, 2,   Snail↓, 31,   Snail↑, 1,   STAC2↓, 1,   talin↓, 1,   TET1↓, 1,   TET1↑, 2,   TGF-β↓, 18,   TGF-β↑, 2,   TGF-β↝, 1,   TGF-β1↓, 2,   TIMP1↓, 1,   TIMP1↑, 11,   TIMP2↓, 2,   TIMP2↑, 4,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 3,   TumCA↓, 2,   TumCI↓, 96,   TumCMig↓, 98,   TumCMig↑, 2,   TumMeta↓, 78,   TumMeta↑, 4,   TumPF↓, 1,   Twist↓, 22,   Tyro3↓, 1,   uPA↓, 21,   uPAR↓, 2,   Vim?, 1,   Vim↓, 33,   Vim↑, 2,   vinculin↓, 1,   Zeb1↓, 17,   ZEB2↓, 1,   α-SMA↓, 1,   α-SMA↑, 1,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 62,   β-catenin/ZEB1↑, 3,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 93,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   EGR1↑, 2,   Endoglin↑, 1,   eNOS↓, 3,   HIF-1↓, 8,   Hif1a↓, 69,   Hif1a↑, 2,   Hif1a↝, 1,   Hypoxia↓, 1,   LOX1↓, 1,   NO↓, 4,   NO↑, 1,   NO↝, 1,   VCAM-1↓, 2,   VEGF↓, 110,   VEGF↑, 3,   VEGF↝, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 21,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 4,   CLDN1↓, 3,   CLDN1↑, 1,   CLDN2↓, 1,   EPR↑, 1,   GLUT1↓, 17,   GLUT1↑, 2,   GLUT2↓, 2,   GLUT3↑, 1,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 98,   MMP↑, 1,   MPT↑, 6,   OCLN↑, 1,   TJ↑, 1,   TRPM7↓, 4,   TRPV1↑, 2,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD25+↑, 1,   CD4+↑, 2,   CD44↓, 10,   CD47↓, 1,   CD8+↑, 3,   cDC2↓, 1,   COX1↓, 4,   COX2/PTGS2↓, 76,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCL16↓, 1,   CXCR2↓, 1,   CXCR4↓, 12,   CXCR4↑, 1,   DR4↑, 7,   FOXP3↓, 1,   FOXP3↑, 2,   HMGB1↓, 5,   ICAM-1↓, 6,   IFN-γ↓, 2,   IFN-γ↑, 2,   IL1↓, 5,   IL10↓, 6,   IL10↑, 1,   IL12↓, 3,   IL12↑, 2,   IL17↓, 1,   IL1α↓, 1,   IL1β↓, 12,   IL2↓, 2,   IL2↑, 5,   IL22↓, 1,   IL23↓, 1,   IL4↓, 1,   IL6↓, 36,   IL6↑, 1,   IL6↝, 1,   IL8↓, 7,   Imm↑, 11,   Imm↝, 4,   Inflam↓, 29,   Inflam↑, 1,   IRAK1↓, 2,   LRIG1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 4,   MCT1↓, 1,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB?, 1,   NF-kB↓, 171,   NF-kB↑, 3,   NF-kB↝, 3,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 7,   NLRP3↓, 3,   NLRP3↑, 2,   p50↓, 3,   p65↓, 7,   p‑p65↓, 3,   PD-1↓, 4,   PD-L1↓, 9,   PGE2↓, 20,   PSA↓, 7,   PSA↝, 1,   RAGE↓, 2,   SOCS-3↓, 1,   T-Cell↑, 2,   TCF↓, 2,   Th1 response↑, 2,   TLR2↓, 1,   TLR4↓, 3,   TNF-α↓, 30,   TNF-α↑, 4,   TNF-α↝, 1,   TNF-α∅, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRAF2↑, 1,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,   TAMS↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   ADAM10↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 2,   AhR↓, 1,   AR↓, 14,   AR↑, 1,   AR↝, 1,   CYP19↓, 2,   ERα/ESR1↓, 1,   ERβ/ESR2↑, 1,   Estro↝, 1,   EstroRS/ERS↓, 1,   FGF21↓, 1,   PPARα↑, 2,   PPARγ↓, 1,   PPARγ↑, 6,   PPARγ↝, 1,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 4,   BioAv↓, 31,   BioAv↑, 39,   BioAv↝, 11,   BioEnh?, 1,   BioEnh↑, 6,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 152,   ChemoSen⇅, 1,   ChemoSen↝, 1,   CompStab↓, 4,   CompStab↑, 3,   CompStab↝, 3,   CYP1A1↓, 4,   CYP1A1↑, 2,   CYP1A2↓, 1,   CYP1B1↑, 1,   Dose?, 3,   Dose↓, 1,   Dose↑, 6,   Dose↝, 47,   Dose∅, 5,   eff?, 1,   eff↓, 35,   eff↑, 78,   eff↝, 9,   eff∅, 3,   Half-Life↓, 11,   Half-Life↝, 6,   Half-Life∅, 1,   MDR1↓, 5,   MRP1/ABCC1↓, 4,   P-gp/ABCB1↓, 17,   P450↓, 3,   RadioS↑, 44,   selectivity?, 1,   selectivity↑, 57,   selectivity∅, 1,   Synergy↑, 87,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 4,   ALP↓, 3,   AR↓, 14,   AR↑, 1,   AR↝, 1,   AST↓, 3,   BG↓, 2,   BRCA1↓, 1,   BRCA1↑, 1,   BRCA1↝, 1,   p‑BRCA1↑, 1,   CA125∅, 1,   CEA↓, 1,   CRP↓, 3,   E6↓, 1,   E7↓, 1,   EGFR↓, 48,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 6,   ERα/ESR1↓, 1,   EstroRS/ERS↓, 1,   EZH2↓, 7,   FOXM1↓, 5,   HER2/EBBR2↓, 14,   hTERT/TERT↓, 11,   IL6↓, 36,   IL6↑, 1,   IL6↝, 1,   IRes↓, 1,   KRAS↓, 2,   LDH↓, 6,   LDH↑, 2,   Maspin↑, 1,   Myc↓, 4,   NSE↓, 1,   PD-L1↓, 9,   PSA↓, 7,   PSA↝, 1,   RAGE↓, 2,   TF-Ag↓, 1,   TP53↑, 2,   TRIB3↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 57,   AntiCan⇅, 1,   antiD↑, 1,   AntiDiabetic↑, 1,   antiNeop↑, 5,   AntiTum↓, 2,   AntiTum↑, 15,   Appetite↑, 1,   cachexia↓, 3,   cardioP↑, 8,   chemoP↓, 1,   chemoP↑, 27,   chemoPv↑, 17,   ChemoSideEff↓, 5,   cognitive↑, 1,   fatigue↓, 2,   hepatoP↑, 4,   Mucositis↓, 1,   neuroP↑, 4,   NP/CIPN↓, 2,   OS↑, 13,   Pain↓, 2,   PFS↑, 1,   QoL↑, 8,   QoL∅, 1,   radioP↑, 9,   Remission↑, 1,   RenoP↑, 4,   Risk↓, 10,   Sleep↑, 2,   toxicity↓, 16,   toxicity↑, 1,   toxicity↝, 10,   toxicity∅, 1,   TumVol↓, 25,   TumVol∅, 1,   TumW↓, 13,   TumW∅, 1,   Weight↑, 1,   Weight∅, 2,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   AntiViral↑, 1,   Bacteria↑, 1,   GutMicro↑, 10,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 5,  
Total Targets: 1150

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 2,   antiOx↓, 6,   antiOx↑, 105,   ARE↑, 3,   Catalase↑, 48,   Fenton↓, 1,   GCLC↑, 2,   GCLM↑, 2,   GPx↓, 1,   GPx↑, 33,   GPx1↑, 2,   GPx4↑, 3,   GSH↑, 47,   GSH/GSSG↑, 1,   GSR↑, 6,   GSTs↑, 14,   H2O2↓, 5,   H2O2∅, 1,   HDL↓, 1,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 39,   HO-2↓, 1,   hyperG↓, 1,   hyperG↝, 1,   Iron↓, 1,   Iron∅, 1,   i-Iron↓, 1,   Keap1↓, 4,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 33,   MDA↓, 39,   MDA↑, 2,   MPO↓, 5,   NOX↓, 1,   NOX1↓, 1,   NOX2↓, 1,   NOX4↓, 2,   NQO1↑, 6,   Nrf1↑, 1,   NRF2?, 1,   NRF2↓, 2,   NRF2↑, 75,   RNS↓, 5,   ROS?, 1,   ROS↓, 129,   ROS↑, 1,   ROS∅, 1,   mt-ROS?, 1,   SOD↓, 1,   SOD↑, 57,   SOD1↑, 5,   SOD2↑, 1,   TAC↑, 4,   TBARS↓, 2,   Trx↑, 1,   Trx1↑, 1,   uricA↓, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↓, 1,   IronCh↑, 7,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↑, 1,   MFN2↑, 1,   mtDam↓, 1,   OCR↑, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   SIRT3↑, 1,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 5,   5LO↝, 1,   ALAT↓, 13,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 15,   AMPK⇅, 1,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↑, 6,   Buty↑, 1,   cAMP↑, 1,   cytoP450↓, 1,   DGAT1↓, 1,   FAO↑, 1,   FASN↓, 3,   FFA/NEFA↓, 1,   glucose↓, 6,   glucose↑, 2,   glucose↝, 2,   GlucoseCon↑, 4,   GSK‐3β↓, 7,   GSK‐3β↑, 4,   p‑GSK‐3β↑, 1,   H2S↑, 1,   LDHA↑, 1,   LDL↓, 6,   lipidLev↓, 2,   NAD↑, 1,   NADPH↓, 2,   NADPH∅, 1,   PFK↓, 1,   PKM2↓, 1,   PLA2↓, 1,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 7,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 13,   ASC↓, 1,   BAX↓, 6,   BAX↑, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 2,   Bcl-2↑, 7,   Bcl-xL↑, 1,   Casp↓, 1,   Casp1↓, 2,   Casp12↓, 1,   Casp3↓, 14,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 2,   cl‑Casp8↓, 1,   Casp9↓, 4,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   Fas↓, 1,   FasL↓, 1,   Ferroptosis↓, 3,   GranB/GZMB↓, 1,   iNOS↓, 17,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 3,   p38↑, 2,   RIP1↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 19,   Akt↑, 50,   Akt↝, 2,   p‑Akt↓, 4,   p‑Akt↑, 4,   Akt2↓, 1,   CREB↑, 3,   p‑CREB↑, 1,   EGFR↓, 1,   ERK↓, 4,   ERK↑, 10,   p‑ERK↑, 2,   IKKα↓, 2,   IκB?, 1,   IκB↓, 1,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAPK↓, 20,   MAPK↑, 7,   MAPK↝, 2,   mTOR↓, 6,   mTOR↑, 11,   mTOR↝, 1,   p‑mTOR↓, 2,   p‑P70S6K↑, 1,   PI3K↓, 25,   PI3K↑, 54,   PI3K↝, 2,   p‑PI3K↓, 3,   p‑PI3K↑, 1,   PKA↑, 2,   PKCδ↑, 3,   PP2A↑, 3,   PTEN↓, 4,   PTEN↑, 2,   PTP1B↓, 1,   RAS↓, 1,   STAT↓, 2,   STAT3↓, 2,   STAT3↑, 3,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 6,   ATF2↑, 1,   ATF4↓, 1,   cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   FOXO1↝, 1,   FOXO3↑, 1,   HDAC↓, 1,   HOTAIR↑, 1,   miR-107↑, 1,   other↓, 2,   other↑, 6,   other↝, 8,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   p‑eIF2α↓, 1,   ER Stress↓, 4,   GRP78/BiP↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   HSP90↑, 1,   HSPs↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3II↑, 1,   MitoP↑, 1,   p62↓, 2,   p62↑, 3,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   DNArepair↑, 2,   p16↓, 2,   P53↓, 2,   PARP1↓, 1,   PCNA↓, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   Ki-67↑, 1,   P21↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↑, 1,   Jun↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 3,   NOTCH1↑, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 12,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 3,   Cartilage↑, 2,   COL1↓, 1,   COL1↑, 1,   E-cadherin↑, 1,   Fibrosis↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP3↓, 1,   MMP9↓, 6,   Rho↓, 1,   SLIT2↑, 1,   TGF-β↓, 4,   TGF-β↑, 1,   TGF-β1↓, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   Vim↓, 1,   α-SMA↓, 4,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 3,   CD31/PECAM-1↓, 2,   E-sel↓, 1,   eNOS↑, 3,   Hif1a↓, 5,   Hif1a↑, 2,   NO↓, 7,   VCAM-1↓, 6,   VEGF↓, 6,   VEGF↑, 2,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 14,   BBB↝, 1,   GastroP↑, 1,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 4,   H+/K+-ATPase↓, 1,   IBI↑, 4,   MMP↑, 12,   MMP∅, 1,   MUC5AC↓, 1,   NHE3↑, 1,   OCLN↝, 1,   TJ↑, 2,   TRPC1↓, 1,   TRPM7↓, 1,   VGSC↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD25+↑, 1,   CD4+↑, 2,   COX1↓, 3,   COX2/PTGS2↓, 35,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 4,   IL10↑, 4,   IL12↓, 1,   IL17↓, 4,   IL18↓, 3,   IL1β↓, 28,   IL2↓, 1,   IL23↓, 1,   IL4↓, 4,   IL4↑, 1,   IL5↓, 3,   IL6?, 1,   IL6↓, 41,   IL8↓, 6,   Imm↑, 10,   Imm⇅, 2,   Inflam↓, 121,   Inflam↑, 1,   IRF3↓, 1,   LPS↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 2,   MyD88↓, 2,   NeuroI↓, 1,   NF-kB↓, 62,   NF-kB↑, 1,   NLRP3↓, 10,   NLRP3↑, 1,   p65↓, 1,   PGE1↓, 1,   PGE2↓, 14,   RAGE↓, 2,   SOCS-3↓, 1,   TLR2↓, 2,   TLR4↓, 8,   TNF-α↓, 47,   Treg lymp↝, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 5,   Ach↑, 4,   AChE↓, 22,   AChE↑, 1,   ADAM10↑, 2,   BChE↓, 3,   BDNF↑, 14,   ChAT↑, 1,   GABA↑, 2,   MAOA↓, 7,   MAOB↓, 2,   NGF↑, 5,   TPH1↓, 1,   TrkB↓, 1,   TrkB↑, 6,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 4,   Aβ↓, 22,   Aβ42↓, 3,   BACE/β-secretase↓, 10,   BACE/β-secretase↑, 1,   IDE↑, 1,   PSEN1/PS1↓, 1,   tau↓, 7,   p‑tau↓, 9,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   CYP19↓, 1,   GLP-1R↑, 1,   GR↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 4,   p‑PPARγ↓, 1,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 34,   BioAv↑, 31,   BioAv↝, 30,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 1,   Dose↓, 2,   Dose↑, 3,   Dose⇅, 1,   Dose↝, 18,   eff↓, 1,   eff↑, 11,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 2,   Half-Life↓, 2,   Half-Life↝, 8,   Half-Life∅, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 13,   ALP↓, 2,   AST↓, 16,   BloodF↑, 2,   BMD↑, 3,   BP↓, 4,   BP↝, 1,   creat↓, 2,   CRP↓, 7,   EGFR↓, 1,   Ferritin↑, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 41,   IRes↓, 1,   IRes↑, 1,   IRes↝, 1,   LDH↓, 7,   LDH↑, 1,   RAGE↓, 2,   SpO2↑, 1,   TP53↑, 1,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 3,   AntiAge↑, 5,   antiAll↑, 18,   AntiArt↑, 9,   AntiCan↑, 17,   antiCG↑, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 26,   AntiMyl↑, 1,   antiPs↑, 3,   AntiTum↓, 1,   AntiTum↑, 7,   Bone Healing↑, 1,   cardioP?, 1,   cardioP↑, 40,   CardioT↓, 1,   chemoP↑, 8,   chemoPv↑, 6,   cognitive↑, 31,   cough?, 1,   diuretic↑, 3,   fatigue↓, 2,   hepatoP↑, 41,   Learn?, 1,   Learn↑, 3,   memory?, 1,   memory↑, 32,   motorD↑, 4,   Mucositis↓, 2,   neuroP↑, 95,   Obesity↓, 11,   OS↑, 1,   Pain↓, 4,   radioP↑, 6,   RenoP↓, 1,   RenoP↑, 13,   Risk↓, 2,   SoreThr?, 1,   Strength↑, 2,   Stroke↓, 11,   toxicity?, 1,   toxicity↓, 25,   toxicity↑, 2,   toxicity↝, 9,   toxicity∅, 4,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 8,   AntiFungal↑, 3,   AntiP↑, 4,   AntiViral↑, 10,   Bacteria↓, 16,   Bacteria↑, 1,   GutMicro↑, 16,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 8,  
Total Targets: 501

Scientific Paper Hit Count for: PI3K, Phosphatidylinositide-3-Kinases
21 Fisetin
19 Quercetin
18 Thymoquinone
16 Kaempferol
16 Luteolin
13 Apigenin (mainly Parsley)
13 Curcumin
12 Matrine
11 Inositol
11 Resveratrol
10 Berberine
10 Magnolol
10 Shikonin
9 Baicalein
9 Licorice
8 5-fluorouracil
8 Carvacrol
8 Formononetin
8 Honokiol
8 Sulforaphane (mainly Broccoli)
7 Isovitexin
7 Chrysin
7 Cinnamon
7 Eugenol
7 Isoliquiritigenin
7 Licochalcone A
7 Melatonin
6 Alpha-Lipoic-Acid
6 Cisplatin
6 Dandelion Root
6 Emodin
6 Garcinol
6 Vitexin
6 Lycopene
6 Nimbolide
6 Rosmarinic acid
6 Urolithin
5 Anethole/trans-Anethole
5 Capsaicin
5 Chlorogenic acid
5 Fucoidan
5 Gambogic Acid
5 Ginseng
5 phytic acid, Inositol hexakisphosphate
5 isoorientin
5 Silymarin (Milk Thistle) silibinin
4 Astragalus
4 Beta-Caryophyllene
4 Carnosic acid
4 Propolis -bee glue
4 diet FMD Fasting Mimicking Diet
4 Indole-3-carbinol
4 Ellagic acid
4 Ferulic acid
4 Hyperoside
4 Magnetic Fields
4 Naringin
3 Silver-NanoParticles
3 Allicin (mainly Garlic)
3 Chemotherapy
3 Artemisinin
3 Astaxanthin
3 Bacopa monnieri
3 α-Bisabolol / Chamomile oil
3 Thymol-Thymus vulgaris
3 Centella asiatica / Gotu kola → asiaticoside
3 Radiotherapy/Radiation
3 Diindolylmethane
3 Gallic acid
3 Ginkgolide B
3 Hydrogen Gas
3 HydroxyTyrosol
3 isoquercitrin
3 itraconazole
3 Paclitaxel/Taxol
3 Morin
3 Selenite (Sodium)
3 Vitamin K2
2 Coenzyme Q10
2 Auranofin
2 Ashwagandha(Withaferin A)
2 Trastuzumab
2 Baicalin
2 Biochanin A
2 Betulinic acid
2 Brucea javanica
2 brusatol
2 Boswellia (frankincense)
2 Celecoxib
2 chaetocin
2 Hydroxycinnamic-acid
2 Citric Acid
2 Ursolic acid
2 Deguelin
2 Diclofenac
2 D-limonene
2 EGCG (Epigallocatechin Gallate)
2 Evodiamine
2 Geraniol
2 Ginger/6-Shogaol/Gingerol
2 Hibiscus sabdariffa
2 Inulin Prebiotic
2 Ivermectin
2 low dose naltrexone
2 Linalool
2 Lutein
2 Metformin
2 doxorubicin
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Myricetin
2 Piperine
2 Plumbagin
2 Parthenolide
2 Pterostilbene
2 Aflavin-3,3′-digallate
1 1,8-Cineole
1 HydroxyCitric Acid
1 Acetyl-l-carnitine
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Ascorbyl Palmitate
1 Aloe anthraquinones
1 almonertinib
1 Berbamine
1 Bufalin/Huachansu
1 borneol
1 Caffeic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celastrol
1 Cucurbitacin
1 CUSP9
1 Dichloroacetophenone(2,2-)
1 Sorafenib (brand name Nexavar)
1 flavonoids
1 Bortezomib
1 Flaxseed/Linseed
1 chitosan
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Ginkgetin
1 hydrogen sulfide
1 Isobavachalcone
1 Juglone
1 lambertianic acid
1 Lasiodin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Mung Bean Sprouts
1 mebendazole
1 Magnetic Field Rotating
1 Magnesium
1 Moringa oleifera
1 Mushroom Chaga, Inonotus obliquus
1 Neem
1 sericin
1 Phenethyl isothiocyanate
1 Phenolic Acids
1 Piperlongumine
1 Psoralidin
1 Rhein
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Sanguinarine
1 Selenium NanoParticles
1 acetazolamide
1 Docetaxel
1 Turmerones
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:252  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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