Bcl-2 Cancer Research Results

Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱
Source: HalifaxProj (inhibit) CGL-Driver Genes
Type: Antiapoptotic Oncogene
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.
Scientific Papers found: Click to Expand⟱
7065- GamB,    Gambogic acid: A review of its pharmacological mechanisms against cancer
- Review, Var, NA
AntiTum↑, Apoptosis↑, TumCCA↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, P-gp/ABCB1↓, Shh↓, Pyro↑, Casp3↑, GSDME↑, ChemoSen↑, RadioS↑, BioAv↓, Bcl-2↓, Mcl-1↓, BAX↑, Half-Life↓, ROS↑, miR-21↓, MMP2↓, MMP9↓,
7060- GamB,    New targets for the antitumor activity of gambogic acid in hematologic malignancies
- Review, Melanoma, RPMI-8226
AntiCan↑, TumCP↓, Apoptosis↑, SRC3↓, DIDO1/DIO-1↑, KCNH2/hERG↓, ROS↑, Bcl-2↓, P53↑, cMyc↓, VEGF↓, Casp3↑, cl‑PARP1↑, eff↓,
7059- GamB,    Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells
- in-vitro, CRC, HCT15
TumCP↓, Apoptosis↑, JNK↑, TumCCA↑, cycD1/CCND1↓, P53↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, MMP↓, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓,
7067- GamB,    Gambogic Acid and Its Role in Chronic Diseases
- Review, Var, NA
*NF-kB↓, PI3K↓, Akt↓, STAT3↓, STAT5↓, IL6↓, COX2/PTGS2↓, iNOS↓, MMPs↓, Src↓, PKA↓, CXCR4↑, VEGF↓, Bcl-2↓, Bcl-xL↓, IAP1↓, Mcl-1↓, survivin↓, cycD1/CCND1↓, HSP90↓, HSP70/HSPA5↓, MAPK↓, HATs↓, HDAC↓, FAK↓, ROS↑, MMP7↓, MMP9↓, α-tubulin↑, cl‑PARP↑, TNF-α↓, BID↑, BAD↑, Cyt‑c↑, Casp3↑, Casp9↑, *AntiArt↑, *antiPs↑,
7086- GAR,    Garcinol: An emerging epigenetic modifier with versatile anticancer properties
- Review, Var, NA
AntiCan↑, TumCG↓, TumMeta↓, toxicity↓, Apoptosis↑, angioG↓, *BioAv↝, HATs↓, p300↓, CBP↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, mTOR↓, DFF45↓, survivin↓, N-cadherin↓, Twist↓, MMP2↓, MMP3↓, MMP9↓, Mcl-1↓, EZH2↓, NOTCH↓, CXCR4↓, PGE2↓, VEGF↓, mPGES-1↓, CycB/CCNB1↓, CDK2↓, CDK4/6↓, iNOS↓, COX2/PTGS2↓, IL1↓, TNF-α↓, PARP↑, Bcl-2↓, CompStab↝,
805- GAR,  Cisplatin,  PacT,    Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells
- Review, Var, NA
ERK↓, PI3K/Akt↓, Wnt/(β-catenin)↓, STAT3↓, NF-kB↓, ChemoSen↑, COX2/PTGS2↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, VEGF↓, TGF-β↓, HATs↓, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↓, Let-7↑, MMP9↓, TumCCA↑, ROS↑, MMP↓, IL6↓, NOTCH1↓, antiNeop↑,
802- GAR,    Garcinol acts as an antineoplastic agent in human gastric cancer by inhibiting the PI3K/AKT signaling pathway
- in-vitro, GC, HGC27
TumCP↓, TumCI↓, Apoptosis↑, PI3K/Akt↓, Akt↓, p‑mTOR↓, cycD1/CCND1↓, MMP2↓, MMP9↓, BAX↑, Bcl-2↓,
801- GAR,  Cisplatin,    Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
- in-vivo, HNSCC, NA
Apoptosis↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, VEGF↓, TumCG↓, Ki-67↓, CD31/PECAM-1↓,
798- GAR,    Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17β-estradiol
- in-vitro, BC, MCF7
TumCP↓, TumCCA↑, Apoptosis↑, ac‑H3↑, ac‑H4∅, NF-kB↓, ac‑p65↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓,
820- GAR,    Garcinol in gastrointestinal cancer prevention: recent advances and future prospects
- Review, GC, NA
Fas↑, TRAIL↑, PARP↑, BAX↑, Bcl-2↓, ROS↑, STAT3↓, Apoptosis↑, MMP2↓, MMP9↓,
823- GAR,    Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10 - in-vitro, CRC, HCT116
Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,
831- GAR,  CUR,    Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells
- in-vitro, AML, HL-60
Apoptosis↑, Casp3↑, MMP↓, Cyt‑c↑, proCasp9↑, Bcl-2↓, BAX↑, PARP↓, DNAdam↑, DFF45↓,
826- GAR,    Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
- vitro+vivo, HCC, HepG2 - vitro+vivo, Liver, HUH7
STAT3↓, TumCP↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCCA↑, TumVol↓,
795- GAR,    Garcinol—A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug
- Review, Var, NA
HATs↓, BAX↑, PARP↑, Bcl-2↓, Casp3↑, Casp9↑, DR5↑, cFLIP↓, MMP2↓, MMP9↓, STAT3↓, p‑Akt↓,
7213- GAs,    Anti-Cancer Properties of Ginkgolic Acids in Human Nasopharyngeal Carcinoma CNE-2Z Cells via Inhibition of Heat Shock Protein 90
- vitro+vivo, NPC, CNE2 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Lung, H1975
ATPase↓, HSP90↓, TumCP↓, *toxicity↝, MMP2↓, MMP9↓, HER2/EBBR2↓, c-Raf↓, Akt↓, Bcl-2↓, other↝,
7233- GAs,    Antitumor effects of ginkgolic acid in human cancer cell occur via cell cycle arrest and decrease the Bcl-2/Bax ratio to induce apoptosis
- in-vitro, Laryn, HEp2
TumCG↓, selectivity↑, Casp3↓, Bcl-2↓, BAX↑, Bax:Bcl2↑, TumCP↓,
7214- GAs,    Ginkgolic Acid Suppresses Nasopharyngeal Carcinoma Growth by Inducing Apoptosis and Inhibiting AKT/NF-κB Signaling
- vitro+vivo, NPC, CNE2
tumCV↓, TumCI↓, Apoptosis↑, Bcl-2↓, BAX↑, PARP↑, Casp3↑, Casp9↑, TumCCA↑, CDK6↓, CycD3↓, ChemoSen↑,
3723- GBE,    Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies
- Review, AD, NA
*memory↑, *antiOx↑, *Casp3↓, *APP↓, *AChE↓, *Aβ↓, *5HT↑, *SOD↓, *MDA↓, *NO↓, *GSH↑, *Bcl-2↑, *BAX↑, *TNF-α↓, *IL1β↑, *iNOS↓, *IL10↓, *p‑tau↓, *ROS↓, *MAOB↓, *cognitive↑, *neuroP↑, *Apoptosis↓,
6565- Ger,    Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrest
- in-vitro, CRC, COLO205
AntiCan↑, mt-Apoptosis↑, BAX↑, Bcl-2↓, DNAdam↑, TumCCA↑,
6567- Ger,    Geraniin inhibits proliferation and induces apoptosis through inhibition of phosphatidylinositol 3-kinase/Akt pathway in human colorectal cancer in vitro and in vivo
- vitro+vivo, CRC, SW480 - in-vitro, CRC, HT29
AntiTum↑, *Inflam↓, *antiOx↓, TumCP↓, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑PI3K↓, p‑Akt↓, Dose↝, TumCG↓,
6570- Ger,    Apoptosis-Mediated Anticancer Activity of Geraniol Inhibits NF-κB, MAPK, and JAK-STAT-3 Signaling Pathways in Human Thyroid Cancer Cells
- in-vitro, Thyroid, TPC-1
*Inflam↓, AntiCan↑, *neuroP↑, tumCV↓, TumCP↓, ROS↑, Apoptosis?, MMP↓, Bcl-2↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, TNF-α↓, NF-kB↓, IL6↓, survivin↓, BAX↑, Casp3↑, JAK2↓, STAT3↓, ERK↓,
6573- Ger,    Systematic elucidation of the mechanism of geraniol via network pharmacology
- Study, Nor, NA - Study, Var, NA
HO-1↝, HRAS↓, *IL8↓, *AChE↓, NF-kB↓, PCNA↓, BAX↑, Bcl-2↓, P53↑, Casp3↑, Casp8↑, Casp9↑,
7201- GGB,    Ginkgolide B Inhibits EMT and Promotes Pyroptosis in Gastric Cancer via AKT/mTOR Pathway
- vitro+vivo, GC, AGS - in-vitro, GC, HGC27
TumCI↓, TumCMig↓, Apoptosis↑, Pyro↑, BAX↑, GSDMD↑, Bcl-2↓, TumCG↓, EMT↓, PCNA↓, N-cadherin↓, E-cadherin↑, PI3K↓, Akt↓, mTOR↓, Dose↝,
7275- GGB,    Protective Effect of Ginkgolide B against Cognitive Impairment in Mice via Regulation of Gut Microbiota
- in-vivo, AD, NA
*cognitive↑, *neuroP↑, *RAGE↓, *BAX↓, *Bcl-2↑, *GutMicro↑,
7277- GGB,    Ginkgolide B inhibits hydrogen peroxide-induced apoptosis and attenuates cytotoxicity via activating the PI3K/Akt/mTOR signaling pathway in H9c2 cells
- in-vitro, Nor, H9c2
*cardioP↑, *Bcl-2↑, *cl‑Casp3↓, *BAX↓, *PI3K↑, *Akt↑, *mTOR↑,
7279- GGB,  Rad,    Radioprotective effect of Ginkgolide B on brain: the mediating role of DCC/MST1 signaling
- in-vivo, Nor, NA
*cognitive↑, *radioP↑, *ROS↓, *p‑Akt↑, *Bcl-2↑, *Mst1↓, *p‑p38↓, *JNK↓, *cl‑Casp3↓, *BAX↓,
7139- GI,    6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer
- vitro+vivo, Lung, A549 - in-vitro, Melanoma, A375 - in-vitro, GBM, U251
HSP60/HSPD1↓, Apoptosis↑, TumCCA↑, mtDam↑, ERK↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, TumCG↓, TumCP↓, TumCG↓, Bcl-2↓, survivin↓, BAX↑, MMP↓, Dose↝,
7138- GI,    6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Pca, DU145 - in-vitro, Liver, HepG2 - in-vitro, Lung, A549
TumCP↓, TumMeta↓, p‑STAT3↓, JAK2↓, cSrc↓, JNK↑, p38↑, ERK↑, eff↓, ROS↑, cl‑PARP↑, TumCCA↑, Casp8↑, Casp9↑, Casp3↑, eff↑, Bcl-2↑, Bcl-xL↓, survivin↓, MMP9↓, COX2/PTGS2↓, IAP1↓, Dose?,
7137- GI,    6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - vitro+vivo, Pca, HMVP2
STAT3↓, TNF-α↓, NF-kB↓, cycD1/CCND1↓, survivin↓, cMyc↓, IL7↓, RANTES↓, BAX↑, Bcl-2↓, P21↑, p27/CDKN1B↑, SOCS1↑, IRF1↑, eff↑, TumVol↓, TumW↓, toxicity↓,
7245- Gink,    Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity
- vitro+vivo, Pca, DU145 - in-vitro, CRC, HCT116 - in-vitro, Nor, MCF10
STAT3↓, cycD1/CCND1↓, survivin↓, Bcl-2↓, Bcl-xL↓, TumCG↓, Dose↝, TumCCA↑, Apoptosis↑, TumVol↓, TumW↓,
7247- Gink,    Ginkgetin inhibits growth of breast carcinoma via regulating MAPKs pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT474 - vitro+vivo, BC, MCF7
TumCP↓, Apoptosis↑, TumCG↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, survivin↓, p‑ERK↑, cl‑JNK↑,
7256- Gink,    Neuroprotective effect of ginkgetin in experimental cerebral ischemia/reperfusion via apoptosis inhibition and PI3K/Akt/mTOR signaling pathway activation
- in-vivo, Stroke, NA
*Stroke↓, *Apoptosis↓, *Casp3↓, *BAX↓, *Bcl-2↑, *p‑Akt↑, *p‑mTOR↑,
7259- Gink,    Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells
- in-vitro, Pca, PC3
tumCV↓, TumCCA↑, Casp3↑, Bcl-2↓, Bcl-xL↓, survivin↓, cycD1/CCND1↓, cl‑PARP↑,
7260- Gink,    Ginkgetin: A natural biflavone with versatile pharmacological activities
- Review, Var, NA - Review, Stroke, NA - Review, AD, NA
*AntiCan↑, *Inflam↓, *AntiBio↑, *neuroP↑, *TumCCA↑, Apoptosis↑, TumAuto↑, iNOS↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PLA2↓, *neuroP↑, *Stroke↓, *AntiFungal↓, *Bacteria↓, Bcl-xL↓, Bcl-2↓, Casp9↑, Casp3↑, cl‑PARP↑, IL6↓, STAT3↓, JAK1↓, survivin↓, COX2/PTGS2↓, IAP1↓, MMP2↓, MMP9↓, PTEN↑, SHP1↑, Synergy↑, TumVol↓, TumW↓, *toxicity↓, *ROS↓,
7266- Gink,    Ginkgo biloba derivative ginkgetin inhibits breast cancer growth by regulating the miRNA-122-5p/GALNT10 axis
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-453 - in-vitro, BC, MCF7
Casp3↑, BAX↑, Cyt‑c↑, Bcl-2↓, TumCP↓, TumCMig↓, Apoptosis↑, miR-122-5p↑, GALNT10↓, TumCG↓,
4505- GLA,    Gamma linolenic acid suppresses hypoxia-induced proliferation and invasion of non-small cell lung cancer cells by inhibition of HIF1α
- in-vitro, NSCLC, Calu-1
TumCP↓, PCNA↓, Ki-67↓, MCM2↓, Bcl-2↓, BAX↑, cl‑Casp3↑, TumCMig↓, TumCI↓, Hif1a↓, VEGF↓,
401- GoldNP,  MF,    In vitro evaluation of electroporated gold nanoparticles and extremely-low frequency electromagnetic field anticancer activity against Hep-2 laryngeal cancer cells
- in-vitro, Laryn, HEp2
Casp3↑, P53↑, BAX↑, Bcl-2↓,
7319- Gos,    BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides
- in-vitro, PC, NA
eff↑, Ca+2↑, BAX↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, RadioS↑,
7321- Gos,    The potential roles of gossypol as anticancer agent: advances and future directions
- Review, Var, NA
other↝, BioAv↑, Bcl-2↓, Casp3↑, Casp9↑, MOMP↑, ROS↑, ATP↓, mtDam↑, Apoptosis↑, hTERT/TERT↓, Akt↓, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, NRF2↓, ARE↓, ICAM-1↓, CX43/GJA1↓, NF-kB↓, TLR4↓, IL6↓, Inflam↓, CUL5↝, CUL1↝, NOXA↑, TumCI↓, TumCMig↓, TumCA↓, FAK↓, MDM2↓, VEGF↓, angioG↓, HLA-I/II↑, Imm↑, Dose↝, Glycolysis↓, OXPHOS↓,
7320- Gos,    AT-101 Enhances the Antitumor Activity of Lenalidomide in Patients with Multiple Myeloma
- Trial, Melanoma, NA
Bcl-2↓, Mcl-1↓, Apoptosis↑, Synergy↑, toxicity↝, ORR↑,
7318- Gos,    -(-)Gossypol promotes the apoptosis of bladder cancer cells in vitro
- in-vitro, Bladder, NA
ChemoSen↑, Bcl-2↓, Mcl-1↓, BIM↑, PUMA↑,
7317- Gos,    A phase II study of AT-101 (gossypol) in chemotherapy-sensitive recurrent extensive stage small cell lung cancer (ES-SCLC)
- Trial, Lung, NA
Bcl-2↓, Bcl-xL↓, Mcl-1↓, NOXA↑, PUMA↑, Dose↝, eff↓,
7316- Gos,  PacT,  carbop,  Chemo,    A phase I study of AT-101, a BH3 mimetic, in combination with paclitaxel and carboplatin in solid tumors
- Trial, Var, NA
Bcl-2↓, Bcl-xL↓, Mcl-1↓, Dose↝, toxicity↝,
7312- Gos,    A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum
- vitro+vivo, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
eff↑, TumAuto↑, TumCG↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, Apoptosis↑, eff↑,
7311- Gos,    Systematic Review of Gossypol/AT-101 in Cancer Clinical Trials
- Review, CLL, NA
Dose↝, toxicity↓, PFS↓, OS↑, Synergy↑, BioAv↑, Bcl-2↓, ROS↑, MOMP↑, Dose↑, Casp3↑, Casp9↑, MMP↑, VEGF↓, APE1/APEX1↓, ChemoSen↑, RadioS↑, toxicity↑, AST↑, ALAT↑,
7309- Gos,    Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa
- vitro+vivo, Pca, PC3
Bcl-2↓, Bcl-xL↓, Mcl-1↓, TumCG↓, Apoptosis↓, ChemoSen↑,
7338- Gra,    Pharmacological Activities of Soursop (Annona muricata Lin.)
- Review, Var, NA
AntiCan↑, *AntiDiabetic↑, *Diar↓, *Bacteria↓, *AntiViral↑, *Wound Healing↑, MMP2↓, MMP9↓, MMP↓, ROS↑, TumCCA↑, BAX↑, Bcl-2↓, Casp3↑, *BAX↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *NO↑, *PGE2↑, *HSP70/HSPA5↑,
843- Gra,    Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling
- in-vitro, NMSC, A431 - in-vitro, NMSC, UW-BCC1 - in-vitro, Nor, NHEKn
TumCG↓, TumCCA↑, Cyc↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, Sufu↑, BAX↑, Bcl-2↓, *toxicity↓,
841- Gra,    The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach
- in-vitro, CRC, HT-29 - in-vitro, Nor, CCD841
PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,
838- Gra,    Antiproliferative activity of aqueous leaf extract of Annona muricata L. on the prostate, BPH-1 cells, and some target genes
- in-vitro, Pca, BPH1
BAX↑, Bcl-2↓, TumVol↓,

Showing Research Papers: 401 to 450 of 856
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 856

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 4,   antiOx↑, 9,   antiOx⇅, 2,   ARE↓, 1,   ARE↑, 1,   Catalase↓, 15,   Catalase↑, 12,   Copper↑, 1,   ENOX2↓, 1,   Fenton↑, 2,   frataxin↑, 1,   GPx↓, 4,   GPx↑, 8,   GPx1↓, 1,   GPx4↓, 8,   GPx4↑, 1,   GSH↓, 51,   GSH↑, 9,   GSH/GSSG↓, 1,   GSR↓, 1,   GSR↑, 4,   GSS↑, 1,   GSTs↓, 2,   GSTs↑, 3,   H2O2↓, 1,   H2O2↑, 7,   HO-1↓, 8,   HO-1↑, 14,   HO-1↝, 1,   Iron↑, 3,   i-Iron↑, 1,   c-Iron↑, 1,   lipid-P↓, 9,   lipid-P↑, 19,   lipid-P↝, 1,   MDA↓, 6,   MDA↑, 14,   MPO↓, 1,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1↓, 3,   NQO1↑, 7,   NRF2↓, 20,   NRF2↑, 21,   NRF2⇅, 1,   NRF2↝, 1,   p‑NRF2↓, 1,   PAO↑, 1,   Prx6↑, 1,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 4,   ROS↓, 28,   ROS↑, 346,   ROS⇅, 9,   ROS↝, 2,   ROS∅, 1,   i-ROS↑, 4,   mt-ROS↑, 8,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 18,   SOD↑, 14,   SOD1↓, 2,   SOD1↑, 2,   SOD2↓, 6,   SOD2↑, 4,   TAC?, 1,   TAC↓, 1,   TBARS↓, 1,   Thiols↓, 3,   Trx↓, 2,   Trx1↑, 1,   ox-Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 6,   TrxR1↓, 7,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 2,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   Bfl-1↓, 1,   CDC2↓, 11,   CDC2↑, 1,   CDC25↓, 17,   compI↓, 2,   compIII↓, 2,   compV↓, 1,   EGF↓, 5,   ETC↓, 4,   HSP60/HSPD1↓, 1,   MCU↓, 1,   mitResp↓, 3,   mitResp↑, 1,   MKK7↓, 1,   mtDam↑, 27,   OCR↓, 6,   OXPHOS↓, 8,   mt-OXPHOS↓, 2,   PDH↓, 2,   PDH↑, 2,   PDH↝, 1,   PHB↓, 1,   PHB↑, 1,   PINK1↑, 3,   SIRT3↓, 3,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1,   12LOX↓, 3,   5LO↓, 3,   ACC↑, 4,   p‑ACC↑, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 4,   ACSL4↑, 1,   ALAT↓, 2,   ALAT↑, 1,   ALAT∅, 1,   ALDOA↓, 1,   AMP↑, 1,   AMPK?, 1,   AMPK↓, 3,   AMPK↑, 26,   p‑AMPK↑, 3,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 23,   e-ATP↑, 1,   CAIX/CA9↓, 4,   CAIX/CA9↑, 1,   i-Cer↑, 1,   ENO1↓, 4,   FAO↑, 1,   FASN↓, 10,   FBI-1↓, 1,   FFA/NEFA↓, 1,   GALNT10↓, 1,   GAPDH↓, 3,   GLO-I↓, 1,   GLS↓, 1,   glucose↓, 3,   GlucoseCon↓, 7,   GlutaM↓, 1,   GlutMet↓, 2,   Glycolysis↓, 29,   GSK‐3β↓, 12,   GSK‐3β↑, 8,   p‑GSK‐3β↓, 6,   p‑GSK‐3β↑, 1,   H2S↑, 1,   HK1↓, 1,   HK2↓, 14,   HMG-CoA↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 10,   lactateProd↑, 1,   LDHA↓, 8,   LDL↓, 3,   lipidLev↓, 1,   MCT4↓, 1,   NAD↝, 1,   NADPH↓, 3,   NADPH↑, 1,   O-Glc↓, 1,   PCK1↓, 1,   PDK1 / PDPK1↓, 11,   PDKs↓, 1,   PFK↓, 2,   PFKFB4?, 1,   PFKP↓, 1,   PKM2↓, 12,   PLA2↓, 1,   Pyruv↓, 1,   Pyruv↑, 1,   p‑S6↓, 1,   SIRT1↓, 7,   SIRT1↑, 7,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   SSAT↑, 1,   TCA?, 1,   TCA↓, 3,   TCA↑, 1,   TS↓, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

AIF↑, 22,   AIF↝, 1,   APAF1↑, 15,   Apoptosis?, 4,   Apoptosis↓, 16,   Apoptosis↑, 426,   Apoptosis↝, 1,   mt-Apoptosis↑, 6,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 2,   p‑ASK1↑, 1,   BAD?, 1,   BAD↓, 5,   BAD↑, 25,   p‑BAD↓, 1,   Bak↓, 1,   Bak↑, 22,   BAX↓, 11,   BAX↑, 505,   BAX⇅, 1,   BAX↝, 3,   BAX∅, 1,   Bax:Bcl2↑, 26,   Bcl-2?, 1,   Bcl-2↓, 764,   Bcl-2↑, 18,   Bcl-2↝, 3,   Bcl-2∅, 2,   cl‑Bcl-2↓, 1,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 116,   Bcl-xL↑, 3,   Bcl-xL↝, 1,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 17,   BIM↓, 1,   BIM↑, 17,   BNIP3?, 2,   BNIP3↑, 5,   BOK↑, 2,   Casp↓, 1,   Casp↑, 56,   cl‑Casp↑, 2,   Casp1↓, 2,   Casp1↑, 4,   Casp10↑, 2,   Casp12?, 1,   Casp12↑, 6,   Casp12↝, 1,   cl‑Casp12↑, 2,   Casp2↑, 3,   Casp3?, 3,   Casp3↓, 6,   Casp3↑, 331,   Casp3↝, 2,   Casp3∅, 1,   cl‑Casp3↓, 1,   cl‑Casp3↑, 93,   proCasp3↓, 3,   proCasp3↑, 3,   Casp6↑, 2,   Casp7?, 1,   Casp7↑, 32,   cl‑Casp7↑, 8,   Casp8↓, 1,   Casp8↑, 67,   cl‑Casp8↑, 14,   proCasp8↑, 2,   pro‑Casp8↑, 1,   Casp9?, 1,   Casp9↓, 1,   Casp9↑, 194,   Casp9∅, 1,   p‑Casp9↑, 2,   cl‑Casp9↑, 37,   proCasp9↓, 1,   proCasp9↑, 3,   CellShr↑, 1,   cFLIP↓, 10,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 180,   Cyt‑c↝, 4,   Cyt‑c?, 1,   cl‑Cyt‑c↑, 1,   Diablo↑, 8,   DIDO1/DIO-1↑, 1,   DR5↑, 34,   FADD↑, 12,   Fas↓, 2,   Fas↑, 35,   FasL↓, 1,   FasL↑, 18,   Ferroptosis↑, 9,   GranB/GZMB↝, 1,   GSDMD↑, 1,   GSDME↑, 1,   cl‑GSDME↑, 1,   GSDME-N↑, 1,   HEY1↓, 2,   IAP1↓, 21,   IAP2/BIRC3↓, 7,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 2,   iNOS↓, 17,   iNOS↑, 2,   Mcl-1↓, 64,   MDM2↓, 16,   MDM2↑, 1,   p‑MDM2↓, 2,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↓, 2,   MOMP↑, 8,   NAIP↓, 2,   Necroptosis↑, 3,   necrosis↑, 4,   NOXA↑, 8,   p38↓, 7,   p38↑, 32,   p‑p38↓, 7,   p‑p38↑, 13,   Paraptosis↑, 2,   Perforin↝, 1,   pS2/TFF1↓, 1,   PUMA↑, 10,   Pyro↑, 7,   RIP3↑, 2,   p‑RIP3↑, 1,   survivin↓, 118,   survivin↑, 1,   survivin↝, 1,   TNFR 1↑, 4,   TRAIL↑, 9,   TRAILR↑, 2,   TumCD↓, 2,   TumCD↑, 29,   TUNEL↑, 1,   XIAP?, 1,   XIAP↓, 56,   XIAP↑, 1,   YAP/TEAD↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 182,   Akt↑, 6,   Akt↝, 1,   p‑Akt↓, 70,   p‑Akt↑, 1,   AKT1↓, 6,   Akt2↓, 1,   AMPKα↑, 1,   BRAF↝, 1,   CaMKII ↓, 2,   Cavin3↓, 1,   CIP2A↓, 1,   CK2↓, 4,   cMET↓, 2,   p‑cMET↑, 2,   cSrc↓, 4,   EGFR↓, 31,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 60,   ERK↑, 17,   p‑ERK↓, 27,   p‑ERK↑, 6,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 15,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 3,   Hippo↓, 1,   HRAS↓, 1,   IGF-1R↓, 3,   IGFR↓, 1,   IKKα↓, 10,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB↓, 1,   IκB↑, 2,   p‑IκB↓, 2,   JAK↓, 5,   JAK1↓, 8,   JAK1↑, 1,   JAK2↓, 23,   p‑JAK2↓, 2,   JNK↓, 5,   JNK↑, 33,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 10,   cl‑JNK↑, 1,   LATS1↓, 1,   LIFR/CD118↓, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 40,   MAPK↑, 20,   MAPK↝, 1,   p‑MAPK↓, 3,   p‑MAPK↑, 4,   MARK4↓, 2,   MEK↓, 6,   p‑MEK↓, 2,   p‑MEK↑, 1,   MKK4↓, 1,   Mst1↑, 1,   mTOR↓, 91,   mTOR↑, 3,   mTOR↝, 1,   p‑mTOR↓, 22,   mTORC2↓, 4,   p‑p42↓, 1,   p70S6↓, 1,   p70S6↑, 1,   P70S6K↓, 6,   p‑P70S6K↓, 2,   p‑P90RSK↑, 1,   PDE3B↓, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 3,   PI3K↓, 130,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 16,   p‑PI3K↑, 1,   PI3K/Akt↓, 9,   PI3K/Akt↑, 1,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 1,   PI3k/Akt/mTOR↝, 1,   PIAS-3↑, 2,   PIK3CA↓, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 8,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 3,   PTEN↑, 33,   PTEN↝, 2,   PTPN6↑, 1,   Raf↓, 8,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 10,   RAS↑, 1,   Rictor↓, 1,   RIP1↓, 1,   RIP1↑, 1,   RTK-RAS↓, 1,   p‑S6K↓, 2,   SHP1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 13,   Src↓, 5,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 6,   STAT3↓, 88,   STAT3↑, 4,   p‑STAT3↓, 22,   p‑STAT3↑, 1,   STAT4↑, 1,   STAT5↓, 2,   STAT6↓, 2,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TSC2↑, 4,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   AntiThr↑, 1,   ATF3↑, 3,   ATF4↓, 1,   ATF4↑, 16,   ATFs↑, 1,   CBP↓, 1,   ChrMod↑, 1,   cJun↓, 7,   cJun↑, 5,   p‑cJun↑, 1,   cMyc↓, 56,   cMyc↑, 2,   DNMT1↓, 8,   DNMT3A↓, 3,   DNMTs↓, 7,   EZH2↓, 5,   FOXM1↓, 7,   FOXO↑, 2,   FOXO1↓, 1,   FOXO1↑, 4,   FOXO3↓, 1,   FOXO3↑, 4,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 3,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 1,   H3K27ac↓, 1,   H4↓, 1,   ac‑H4↑, 1,   ac‑H4∅, 1,   HATs↓, 4,   HATs↑, 1,   HDAC↓, 26,   HDAC1↓, 9,   HDAC10↑, 1,   HDAC2↓, 6,   HDAC3↓, 6,   HDAC4↓, 1,   HDAC6↓, 2,   HES1↓, 1,   HOXB-AS1↓, 1,   IRF1↑, 1,   KCNQ1OT1↓, 1,   miR-106b↓, 2,   miR-107↑, 1,   miR-122-5p↑, 1,   miR-125b↓, 1,   miR-133a-3p↑, 1,   miR-134↑, 1,   miR-139-5p↑, 2,   miR-155↓, 3,   miR-17↓, 1,   miR-195↑, 1,   miR-21↓, 7,   miR-21↑, 1,   miR-221↓, 1,   miR-224↓, 1,   miR-25-5p↑, 1,   miR-27a-3p↓, 3,   miR-27a-3p↑, 1,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 10,   miR-375↓, 1,   miR-375↝, 1,   miR-384↑, 1,   miR-409-3p↑, 1,   miR-422a↑, 1,   miR-497↑, 1,   miR-548ah-5p↑, 1,   miR-590-3p↑, 1,   Myc↓, 7,   n-MYC↓, 2,   NR1D2↓, 1,   OCT4↓, 15,   OCT4↑, 1,   other?, 1,   other↓, 4,   other↑, 4,   other↝, 9,   PhotoS↑, 3,   Set9↑, 1,   sonoS↑, 2,   SOX2↓, 9,   SOX4↑, 1,   SOX9?, 1,   SUV39H↓, 1,   TCF-4↓, 2,   TET3↑, 1,   TFE3↑, 1,   tumCV?, 3,   tumCV↓, 112,   tumCV∅, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 36,   CRT↑, 1,   CUL1↝, 1,   CUL5↝, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 10,   p‑eIF2α↓, 1,   p‑eIF2α↑, 6,   ER Stress↓, 1,   ER Stress↑, 48,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 13,   GRP94↑, 1,   HSF1↓, 1,   HSP27↓, 5,   HSP27↑, 2,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 3,   HSP90↓, 11,   HSP90↑, 3,   HSPs↓, 1,   IRE1↑, 4,   PERK↑, 10,   p‑PERK↑, 2,   SERPINH1/HSP47↓, 1,   UPR↑, 5,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↓, 1,   ATG3↑, 3,   ATG5↑, 10,   ATG7↑, 4,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 29,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 5,   LC3A↑, 2,   LC3B↑, 2,   LC3B-II↑, 5,   LC3I↓, 1,   LC3I↑, 1,   LC3II↓, 3,   LC3II↑, 19,   LC3s↑, 1,   MitoP↑, 1,   p62↓, 11,   p62↑, 5,   PARK2↑, 3,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto?, 1,   TumAuto↑, 55,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATM↑, 4,   ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 3,   DFF45↑, 1,   DNA-PK↑, 1,   DNAdam↓, 2,   DNAdam↑, 76,   mt-DNAdam↑, 1,   DNArepair↓, 4,   DNArepair↑, 1,   ERCC1↓, 2,   ERCC3↑, 1,   hTERT/TERT↓, 10,   MGMT↓, 1,   p16↑, 3,   P53↓, 9,   P53↑, 177,   P53↝, 1,   p‑P53↓, 2,   p‑P53↑, 10,   ac‑P53↑, 1,   p53 Wildtype↓, 1,   PARP↓, 10,   PARP↑, 35,   PARP↝, 1,   p‑PARP↑, 2,   cl‑PARP↓, 3,   cl‑PARP↑, 134,   cl‑PARP∅, 1,   PARP1↓, 2,   PARP1↑, 2,   cl‑PARP1↑, 5,   PCNA↓, 51,   PCNA↑, 1,   POLD1↓, 1,   RAD51↓, 1,   RAD51↑, 1,   SIRT6↓, 1,   Telomerase↓, 11,   TOP1↓, 4,   TOP1↝, 1,   TOP2↓, 5,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 12,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 29,   CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 44,   CDK2↑, 5,   CDK4↓, 51,   CDK4↑, 2,   CDK4/6↓, 3,   CDK6↓, 21,   CDK6↑, 1,   CHK1↓, 4,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 3,   Chk2↑, 1,   ChrCon↑, 3,   Cyc↓, 5,   Cyc↝, 1,   cycA1/CCNA1↓, 14,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 43,   CycB/CCNB1↑, 5,   cycD1/CCND1↓, 143,   cycD1/CCND1↑, 3,   cycD1/CCND1↝, 2,   CycD3↓, 5,   cycE/CCNE↓, 24,   cycE/CCNE↑, 2,   cycE1↓, 3,   cycF↓, 1,   E2F4↑, 1,   E2Fs↓, 3,   FBXO5/EMI1↓, 1,   GADD45A↓, 1,   GADD45A↑, 2,   Ki-67↓, 44,   MAD↓, 1,   mitA↓, 1,   p19↑, 1,   P21?, 1,   P21↓, 8,   P21↑, 92,   P21↝, 2,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 40,   PLK1↓, 1,   pRB↓, 2,   pRB↑, 1,   p‑pRB↓, 3,   RB1↓, 2,   RB1↑, 3,   p‑RB1↓, 2,   cl‑RB1↓, 1,   Securin↓, 1,   TubPol↓, 1,   TumCCA↓, 8,   TumCCA↑, 289,   WEE1↑, 3,   β-Tubulin↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 2,   ALDH↓, 3,   ALDH1A1↓, 3,   BMI1↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 9,   CD133↑, 1,   CD24↓, 1,   CD34↓, 1,   CEBPA↑, 1,   cFos↓, 8,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 37,   Diff↓, 2,   Diff↑, 2,   EIF4E↓, 1,   EP4/PTGER4↑, 1,   FGF↓, 4,   Gli↓, 2,   Gli1↓, 20,   HH↓, 17,   HMGCR↓, 1,   IGF-1↓, 9,   IGF-2↓, 1,   IGFBP3↑, 5,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 44,   Let-7↑, 2,   MCM2↓, 1,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 14,   Nanog↑, 1,   Nestin↓, 3,   NOTCH↓, 13,   NOTCH↑, 1,   NOTCH⇅, 1,   NOTCH1↓, 15,   NOTCH2↓, 1,   NOTCH3↓, 3,   OGFr↑, 2,   p300↓, 1,   PCLAF↓, 1,   PTCH1↓, 9,   PTCH2↓, 1,   SAL↑, 1,   Shh↓, 13,   Smo↓, 9,   p‑STAT1↓, 1,   Sufu↑, 1,   TumCG?, 3,   TumCG↓, 147,   TumCG↑, 4,   TumCP?, 1,   TumCP↓, 229,   TumCP↑, 4,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt?, 1,   Wnt↓, 34,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   AntiAg↑, 3,   AP-1↓, 9,   AP-1↑, 1,   AP-1↝, 2,   ATPase↓, 2,   AXL↓, 4,   Ca+2↓, 4,   Ca+2↑, 40,   Ca+2↝, 3,   i-Ca+2↑, 1,   mt-Ca+2↑, 1,   CAFs/TAFs↓, 2,   cal2↑, 4,   CCN2/CTGF↓, 2,   Cdc42↓, 2,   COL1↓, 2,   COL3A1↓, 1,   CTNNB1↓, 1,   DLC1↑, 3,   E-cadherin↓, 8,   E-cadherin↑, 57,   EMT↓, 72,   EMT↑, 1,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 18,   p‑FAK↓, 3,   Fibronectin↓, 6,   GIT1↓, 1,   GLI2↓, 9,   hnRNPA1↓, 1,   IQGAP3↓, 1,   ITGA5↓, 1,   ITGB1↓, 3,   ITGB3↓, 1,   ITGB4↓, 1,   LAMs↓, 2,   LEF1↓, 3,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 4,   MET↑, 2,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP13↓, 5,   MMP16↓, 1,   MMP2↓, 99,   MMP2↝, 1,   MMP3↓, 9,   MMP7↓, 10,   MMP9↓, 117,   MMPs↓, 32,   MRGPRF↓, 1,   MTA1↓, 2,   MUC4↓, 3,   N-cadherin↓, 37,   NFAT↑, 1,   p44↓, 1,   p‑p44↓, 2,   PAI-1/SERPINE1↑, 1,   PAK1↓, 1,   PAK1↑, 1,   pax↓, 1,   p‑pax↓, 1,   PDGF↓, 4,   Rac1↓, 4,   RECK↑, 2,   Rho↓, 5,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 19,   SMAD2↓, 2,   p‑SMAD2↓, 2,   SMAD3↓, 1,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↑, 1,   Snail?, 1,   Snail↓, 31,   TET1↑, 2,   TGF-β↓, 16,   TGF-β↑, 3,   TIMP1↓, 3,   TIMP1↑, 10,   TIMP2↓, 2,   TIMP2↑, 13,   TIMP3↑, 1,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 2,   TumCA↓, 3,   TumCA↑, 1,   TumCI?, 2,   TumCI↓, 102,   TumCI↑, 1,   TumCMig?, 1,   TumCMig↓, 105,   TumCMig↑, 1,   TumMeta↓, 68,   TumMeta↑, 5,   TumPF↓, 1,   Twist↓, 21,   TXNIP↑, 1,   Tyro3↓, 2,   uPA↓, 21,   uPAR↓, 2,   Vim?, 1,   Vim↓, 41,   Vim↑, 1,   Zeb1↓, 15,   ZEB2↓, 3,   α-SMA↓, 1,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 47,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 83,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 9,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 57,   LOX1↓, 2,   NO↓, 4,   NO↑, 5,   VCAM-1↓, 5,   VEGF↓, 125,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 17,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB∅, 1,   CellMemb↓, 1,   CLDN1↓, 1,   CX43/GJA1↓, 1,   EPR↑, 3,   GLUT1↓, 12,   GLUT1↑, 1,   GLUT3↓, 2,   GLUT3↑, 1,   GLUT4↓, 2,   KCNH2/hERG↓, 1,   MMP↓, 198,   MMP↑, 1,   MPT↑, 5,   NHE1↓, 1,   SLC12A5↝, 1,   TRPM7↓, 1,   TRPV1↑, 2,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   CB2 / CNR2↑, 3,   CCR7↓, 2,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 12,   CD8+↑, 4,   cDC2↓, 5,   COX2/PTGS2↓, 80,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 2,   CXCR2↓, 2,   CXCR4↓, 17,   CXCR4↑, 1,   DR4↑, 12,   FOXP3↓, 2,   FOXP3↑, 1,   HCAR2↑, 1,   HLA↑, 1,   HLA-I/II↑, 1,   HMGB1↓, 1,   HMGB1↑, 1,   ICAM-1↓, 13,   IFN-γ↓, 4,   IFN-γ↑, 5,   IL1↓, 7,   IL1↑, 1,   IL10↓, 4,   IL10↑, 1,   IL12↓, 2,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 16,   IL1β↑, 3,   IL2↓, 2,   IL2↑, 7,   IL33↑, 1,   IL4↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 50,   IL6↑, 2,   IL6↝, 1,   IL7↓, 1,   IL8↓, 13,   Imm↑, 12,   Imm↝, 1,   Inflam↓, 38,   Inflam↝, 1,   LTA/TNF-β↓, 1,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 4,   MCT1↓, 1,   MDSCs↓, 1,   mPGES-1↓, 1,   NAF1↓, 1,   NF-kB?, 1,   NF-kB↓, 175,   NF-kB↑, 11,   NF-kB↝, 1,   p‑NF-kB↓, 3,   p‑NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 2,   NLRP3↑, 2,   p65↓, 10,   p‑p65↓, 5,   ac‑p65↓, 1,   ac‑p65↑, 2,   PD-1↓, 3,   PD-L1↓, 8,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 13,   PSA↓, 9,   PSA↝, 1,   RAGE↓, 2,   RANTES↓, 1,   SOCS-3↑, 1,   SOCS1↑, 2,   T-Cell↑, 3,   TCF↓, 2,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 3,   Th17↑, 1,   TLR4↓, 6,   TLR4↝, 1,   TNF-α↓, 42,   TNF-α↑, 11,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRADD↑, 2,   TRAF1↓, 1,   Treg lymp↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,   BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 1,   AhR↑, 1,   AR↓, 16,   AR↝, 1,   ER-α36↓, 2,   ERα/ESR1↓, 2,   ERβ/ESR2↑, 1,   GR↝, 1,   PPARα↓, 1,   PPARγ↓, 5,   PPARγ↑, 9,   RANKL↓, 1,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 30,   BioAv↑, 33,   BioAv↝, 8,   BioEnh↑, 1,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 144,   ChemoSen↝, 1,   CompStab↑, 3,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1B1↑, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 4,   Dose↓, 3,   Dose↑, 8,   Dose↝, 65,   Dose∅, 8,   eff↓, 88,   eff↑, 89,   eff↝, 8,   GSTA1↑, 1,   GSTM1↑, 1,   GSTP1/GSTπ↓, 1,   Half-Life↓, 7,   Half-Life↝, 8,   Half-Life∅, 1,   MDR1↓, 6,   MDR1↑, 1,   MRP↓, 1,   MRP1/ABCC1↓, 3,   P-gp/ABCB1↓, 18,   P450↓, 2,   RadioS↑, 43,   selectivity↓, 1,   selectivity↑, 108,   Synergy?, 1,   Synergy↑, 99,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 3,   ALAT↓, 2,   ALAT↑, 1,   ALAT∅, 1,   ALP↓, 2,   AR↓, 16,   AR↝, 1,   ascitic↓, 1,   AST↓, 2,   AST↑, 1,   AST∅, 1,   BRAF↝, 1,   BRCA1↓, 2,   BRCA1↑, 1,   CA19-9↓, 1,   CEA↓, 3,   CRP↓, 4,   E6↓, 3,   E7↓, 3,   EGFR↓, 31,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 2,   EZH2↓, 5,   FOXM1↓, 7,   HER2/EBBR2↓, 15,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 10,   IL6↓, 50,   IL6↑, 2,   IL6↝, 1,   LDH?, 1,   LDH↓, 13,   LDH↑, 6,   LDH↝, 2,   i-LDH↓, 1,   Maspin↑, 1,   Myc↓, 7,   NSE↓, 1,   PD-L1↓, 8,   PD-L1↑, 1,   PSA↓, 9,   PSA↝, 1,   PSADT↑, 1,   RAGE↓, 2,   TG/TAG↓, 1,   TP53↑, 3,   TRIB3↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan?, 1,   AntiCan↓, 3,   AntiCan↑, 61,   AntiCan?, 1,   AntiCan∅, 1,   antiCG↓, 1,   antiD↑, 1,   antiNeop↑, 4,   AntiTum↓, 2,   AntiTum↑, 34,   cachexia↓, 2,   cardioP↑, 11,   CardioT↓, 1,   chemoP?, 1,   chemoP↑, 33,   chemoPv↑, 19,   ChemoSideEff↓, 7,   ChemoSideEff∅, 1,   hepatoP↑, 15,   K17↓, 1,   neuroP↑, 8,   NKG2D↑, 1,   Obesity↓, 1,   ORR↑, 1,   OS↑, 9,   Pain↓, 2,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 3,   QoL∅, 1,   radioP↑, 9,   Remission↑, 1,   RenoP↑, 12,   Risk↓, 13,   Symptoms↓, 1,   toxicity?, 1,   toxicity↓, 23,   toxicity↑, 1,   toxicity↝, 12,   toxicity∅, 1,   TumNum↓, 1,   TumVol↓, 43,   TumVol↑, 2,   TumW↓, 22,   Weight↑, 2,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiFungal↑, 1,   Bacteria↓, 5,   GutMicro↑, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 4,   Ingr↝, 11,  
Total Targets: 1240

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 4,   antiOx↑, 90,   ARE↑, 1,   Bil↓, 1,   Catalase↓, 1,   Catalase↑, 52,   Fenton↓, 1,   GPx↓, 1,   GPx↑, 38,   GPx4↑, 2,   GSH↓, 1,   GSH↑, 49,   GSH/GSSG↑, 1,   GSR↑, 5,   GSTs↓, 1,   GSTs↑, 13,   H2O2↓, 5,   HDL↑, 2,   HO-1?, 2,   HO-1↓, 1,   HO-1↑, 26,   HO-2↓, 1,   Iron↓, 2,   Keap1↓, 5,   Keap1↑, 1,   lipid-P↓, 38,   MDA?, 1,   MDA↓, 39,   MDA↑, 1,   MPO↓, 6,   NADH↓, 1,   NOX↓, 1,   NOX4↓, 2,   NQO1↑, 6,   Nrf1↑, 3,   NRF2?, 1,   NRF2↑, 50,   Prx↑, 1,   RNS↓, 5,   ROS?, 1,   ROS↓, 118,   ROS↑, 3,   ROS∅, 3,   SOD?, 1,   SOD↓, 2,   SOD↑, 69,   SOD1↑, 2,   SOD2↑, 4,   TAC↑, 6,   TBARS↓, 4,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   FIS1↓, 1,   Insulin↑, 1,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 5,   OCR↑, 1,   PGC-1α↓, 2,   PGC-1α↑, 2,   PINK1↑, 2,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↝, 1,   ACSL4↓, 1,   ALAT↓, 15,   AMPK↓, 2,   AMPK↑, 9,   p‑AMPK↑, 1,   ATP↓, 2,   ATP↑, 4,   mt-ATP↑, 1,   GAPDH↑, 1,   glucose↓, 5,   glucose↑, 1,   glucose↝, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 3,   H2S↑, 2,   HMG-CoA↓, 1,   LDHA↑, 1,   LDL↓, 3,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 3,   NH3↓, 1,   PFK↓, 1,   PLA2↓, 1,   SIRT1↑, 7,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   APAF1↓, 2,   Apoptosis↓, 31,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 48,   BAX↑, 6,   Bax:Bcl2↓, 2,   Bcl-2↓, 12,   Bcl-2↑, 58,   Bcl-2↝, 1,   Bcl-2∅, 1,   Bcl-xL↑, 1,   Casp1↓, 3,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 35,   Casp3↑, 2,   cl‑Casp3↓, 9,   Casp8↓, 1,   Casp9↓, 10,   cl‑Casp9↓, 4,   Cyt‑c↓, 8,   Cyt‑c↑, 2,   Fas↓, 3,   FasL↓, 1,   Ferroptosis↓, 4,   GSDMD↓, 1,   iNOS↓, 20,   MLKL↓, 1,   p38↓, 2,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 9,   p‑Akt↓, 1,   p‑Akt↑, 7,   Akt2↓, 1,   CaMKII ↓, 1,   CREB↑, 1,   p‑CREB↑, 4,   EGFR↓, 1,   ERK↓, 3,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IKKα↑, 1,   IκB?, 1,   JAK↓, 2,   JAK2↑, 3,   JNK↓, 6,   JNK↑, 1,   MAPK↓, 7,   MAPK↑, 1,   Mst1↓, 2,   mTOR↓, 1,   mTOR↑, 5,   p‑mTOR↓, 1,   p‑mTOR↑, 1,   p‑p70S6↓, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 3,   PI3K↑, 9,   PKA↑, 1,   PKCδ↓, 1,   PKCδ↑, 1,   PP2A↑, 2,   p‑PTEN↓, 1,   RAS↓, 1,   RIP1↓, 1,   STAT3↓, 2,   STAT3↑, 6,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF4↓, 2,   cJun↓, 1,   p‑cJun↓, 1,   FOXO3↑, 1,   HDAC↓, 2,   HDAC2↓, 1,   HOTAIR↑, 1,   other?, 1,   other↓, 2,   other↑, 4,   other↝, 3,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 5,   CHOP/DDIT3↑, 1,   ER Stress↓, 7,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 2,   IRE1↓, 2,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 1,   LC3A↑, 1,   LC3II↓, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↓, 3,   p62↑, 2,   PARK2↑, 3,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 6,   p16↓, 1,   P53↓, 4,   P53↑, 2,   PARP↓, 1,   cl‑PARP↓, 1,   PCNA↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↑, 1,   P21↓, 2,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 2,   NOTCH1↑, 1,   TumCG↓, 1,   TumCP↓, 2,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 6,   AP-1↓, 2,   BACH1↓, 1,   Ca+2↓, 5,   cal2↓, 2,   Cartilage↑, 1,   E-cadherin↓, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 1,   MMP9↓, 2,   MUC1↑, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 2,   TregCell↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,   TXNIP↓, 1,   Zeb1↓, 1,   α-SMA↓, 2,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   CD31/PECAM-1↓, 1,   E-sel↓, 2,   eNOS↑, 1,   Hif1a↓, 1,   NO?, 1,   NO↓, 15,   NO↑, 3,   VCAM-1↓, 3,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 9,   BBB↝, 2,   BBB∅, 2,   CLDN4↑, 1,   GastroP↑, 5,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 2,   MMP↓, 2,   MMP↑, 12,   MMP∅, 1,   MPT↑, 1,   MUC5AC↓, 1,   OCLN↑, 2,   OCLN↝, 1,   TJ↑, 3,   TRPV1↑, 1,   ZO-1↓, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 26,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 7,   IL10↑, 5,   IL13↑, 1,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 31,   IL1β↑, 1,   IL2↓, 1,   IL22↓, 1,   IL4↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 38,   IL6↑, 1,   IL8↓, 8,   Imm↓, 1,   Imm↑, 6,   Inflam↓, 108,   Inflam↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   MIP‑1α/CCL3↓, 1,   MyD88↓, 1,   NeuroI↓, 6,   NF-kB↓, 39,   NF-kB↑, 3,   NK cell↑, 1,   NLRP3↓, 7,   PGE2↓, 9,   PGE2↑, 1,   PSA∅, 1,   RAGE↓, 4,   RANTES↓, 1,   TLR4↓, 6,   TNF-α↓, 55,   TNF-α↑, 1,   TRAF1↓, 1,   Treg lymp↝, 1,   TRIF↓, 1,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 4,   AChE↓, 21,   ADAM10↑, 1,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 16,   BDNF⇅, 1,   ChAT↑, 3,   MAOA↓, 2,   MAOB↓, 2,   NGF↑, 4,   PSD95↑, 3,   RELN↑, 1,   SNAP25↑, 2,   SYP↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 3,   Aβ↓, 18,   Aβ42↓, 3,   BACE/β-secretase↓, 7,   IDE↑, 1,   PSEN1/PS1↓, 1,   tau↓, 3,   p‑tau↓, 6,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   Estro↓, 1,   GR↑, 1,   PPARα↑, 1,   PPARγ↑, 3,   p‑PPARγ↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 27,   BioAv↑, 34,   BioAv↝, 20,   BioAv∅, 1,   BioEnh↑, 1,   ChemoSen↑, 1,   CompStab↑, 1,   CYP2D6↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 13,   Dose∅, 1,   eff↓, 4,   eff↑, 9,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 14,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   selectivity↑, 2,   Synergy↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 15,   ALP↓, 4,   AST↓, 17,   Bil↓, 1,   BMD↑, 2,   BP↓, 4,   BUN?, 1,   BUN↓, 1,   colonLen↑, 1,   creat↓, 4,   CRP↓, 4,   EGFR↓, 1,   Ferritin↑, 1,   hs-CRP↓, 1,   IL6↓, 38,   IL6↑, 1,   LDH↓, 8,   NOS2↓, 1,   PSA∅, 1,   RAGE↓, 4,   SpO2↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 3,   AntiAge↑, 1,   antiAll↑, 12,   AntiArt↑, 8,   AntiCan↑, 18,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 20,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 6,   ANXi↓, 1,   cardioP?, 2,   cardioP↑, 39,   CardioT↓, 1,   chemoP↑, 4,   chemoPv↑, 5,   cognitive↑, 22,   diuretic↑, 3,   hepatoP↓, 2,   hepatoP↑, 33,   Learn↑, 4,   memory↑, 22,   motorD↑, 5,   Mucositis↓, 2,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 70,   Obesity↓, 8,   OS↑, 1,   Pain↓, 3,   radioP↑, 5,   RenoP↓, 1,   RenoP↑, 11,   Risk↓, 2,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 10,   toxicity?, 1,   toxicity↓, 21,   toxicity↑, 3,   toxicity↝, 6,   toxicity∅, 9,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 13,   AntiFungal↓, 1,   AntiFungal↑, 5,   AntiP↓, 1,   AntiP↑, 4,   AntiViral↑, 12,   Bacteria↓, 20,   Bacteria↑, 1,   Diar↓, 3,   GutMicro↑, 12,   Inf↓, 1,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 6,  
Total Targets: 489

Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2
36 Curcumin
32 Silver-NanoParticles
29 Thymoquinone
25 Quercetin
18 Luteolin
17 Apigenin (mainly Parsley)
15 Baicalein
15 EGCG (Epigallocatechin Gallate)
13 Allicin (mainly Garlic)
13 Sulforaphane (mainly Broccoli)
13 Betulinic acid
12 Fisetin
12 Shikonin
11 Berberine
11 Emodin
11 Honokiol
11 Silymarin (Milk Thistle) silibinin
10 Cisplatin
10 Melatonin
10 Resveratrol
10 Gambogic Acid
10 Garcinol
10 Licochalcone A
10 Matrine
9 Eugenol
9 Gossypol/AT-101
9 Lycopene
8 Capsaicin
8 Graviola
8 Magnolol
8 Morin
7 Magnetic Fields
7 Ashwagandha(Withaferin A)
7 D-limonene
7 Radiotherapy/Radiation
7 Beta-Caryophyllene
7 Carvacrol
7 Isoliquiritigenin
7 Juglone
7 Nimbolide
7 Piperlongumine
6 5-fluorouracil
6 Paclitaxel/Taxol
6 Phenethyl isothiocyanate
6 Boron
6 Cinnamon
6 Ursolic acid
6 Dandelion Root
6 Ferulic acid
6 Formononetin
6 Ginkgetin
6 Hibiscus sabdariffa
6 Hyperoside
6 isoorientin
6 Kaempferol
6 lambertianic acid
6 Licorice
5 Astragalus
5 Artemisinin
5 Astaxanthin
5 doxorubicin
5 Benzyl isothiocyanate
5 Boswellia (frankincense)
5 Carnosic acid
5 Cynaropicrin
5 Isobavachalcone
5 Mushroom Lion’s Mane, Hericium erinaceus
5 Rosmarinic acid
5 Urolithin
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Photodynamic Therapy
4 Alpha-Lipoic-Acid
4 Isovitexin
4 Metformin
4 Aloe anthraquinones
4 Biochanin A
4 Chemotherapy
4 Bufalin/Huachansu
4 α-Bisabolol / Chamomile oil
4 Crocetin
4 Ellagic acid
4 Eurycomanone
4 Geraniol
4 Ginkgolide B
4 HydroxyTyrosol
4 Indole-3-carbinol
4 Isorhamnetin
4 isoquercitrin
4 Ivermectin
4 Moringa oleifera
4 Propolis -bee glue
3 3-bromopyruvate
3 Açaí, Euterpe oleracea
3 Gemcitabine (Gemzar)
3 Allyl isothiocyanate
3 immunotherapy
3 Berbamine
3 Caffeic acid
3 Chlorogenic acid
3 chaetocin
3 chitosan
3 Chlorophyllin
3 Chrysin
3 Docetaxel
3 Evodiamine
3 Gallic acid
3 Ginkgolic acids
3 Ginger/6-Shogaol/Gingerol
3 Vitexin
3 L-Theanine
3 Laetrile B17 Amygdalin
3 Oleuropein
3 Patchouli Oil (Pogostemon cablin)
3 Phenylbutyrate
3 Selenite (Sodium)
3 VitK3,menadione
2 tamoxifen
2 Ajoene (compound of Garlic)
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 DTS(dibenzyl trisulphide) from Anamu
2 Andrographis
2 beta-glucans
2 Baicalin
2 Brucea javanica
2 brusatol
2 Bromelain
2 borneol
2 Genistein (soy isoflavone)
2 Butyrate
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Citric Acid
2 Carvone
2 Polyphenols
2 Cucurbitacin
2 Electrical Pulses
2 Chlorella (Chlorella vulgaris)
2 Flaxseed/Linseed
2 carboplatin
2 Hydrogen Gas
2 iodine
2 itraconazole
2 Lactobacillus
2 low dose naltrexone
2 Lemongrass Extract/Citral
2 SDG/lignans
2 Linalool
2 Lutein
2 Mangiferin
2 Methylglyoxal
2 Marjoram (Origanum majorana)
2 Propyl gallate
2 Phycocyanin
2 Rauwolfia serpentina/Indian Snakeroot
2 salinomycin
2 Selenium
2 Taurine
2 Vitamin K2
1 Coenzyme Q10
1 Acoschimperoside P, 2’-acetate
1 SonoDynamic Therapy UltraSound
1 Camptothecin
1 alpha Linolenic acid
1 Anethole/trans-Anethole
1 Angelica archangelica / Garden Angelica
1 Aspirin
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 epirubicin
1 Isothiocyanates
1 selenomethionine
1 Black turtle bean
1 Zinc
1 Celastrol
1 Prebiotic
1 Cichoric acid / Chicoric acid
1 methotrexate
1 Hydroxycinnamic-acid
1 Citicoline, CDP-Choline
1 Copper and Cu NanoParticles
1 Oxaliplatin
1 CUSP9
1 Dichloroacetophenone(2,2-)
1 Dichloroacetate
1 Deguelin
1 Date Fruit Extract
1 Diindolylmethane
1 Fenbendazole
1 olaparib/LYNPARZA
1 Galloflavin
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Grapeseed extract
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 Hyperthermia
1 Huperzine A/Huperzia serrata
1 Rutin
1 Butein
1 Scopoletin
1 Vitamin C (Ascorbic Acid)
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lactoferrin/Talactoferrin
1 Methylene blue
1 mebendazole
1 MCT, metronomic chemo
1 methylseleninic acid
1 Magnetic Field Rotating
1 Moringin
1 Zeolite
1 Methylsulfonylmethane
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Shiitake, AHCC
1 Naringin
1 Neem
1 Oleocanthal
1 Orlistat
1 sericin
1 Physalin F & B
1 Piperine
1 Plumbagin
1 Psoralidin
1 Parthenolide
1 Pterostilbene
1 isoflavones
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 polyethylene glycol
1 Selenium NanoParticles
1 Sesamin
1 Auranofin
1 Salvia miltiorrhiza
1 Spirulina(Arthrospira/Limnospira)
1 Spermidine
1 Terpinen-4-ol / Tea Tree Oil
1 Terpenoids
1 Aflavin-3,3′-digallate
1 Tomatine
1 Vitamin D3
1 Zerumbone
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:27  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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