TumCI Cancer Research Results

TumCI, Tumor Cell invasion: Click to Expand ⟱
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Tumor cell invasion is a critical process in cancer progression and metastasis, where cancer cells spread from the primary tumor to surrounding tissues and distant organs. This process involves several key steps and mechanisms:

1.Epithelial-Mesenchymal Transition (EMT): Many tumors originate from epithelial cells, which are typically organized in layers. During EMT, these cells lose their epithelial characteristics (such as cell-cell adhesion) and gain mesenchymal traits (such as increased motility). This transition is crucial for invasion.

2.Degradation of Extracellular Matrix (ECM): Tumor cells secrete enzymes, such as matrix metalloproteinases (MMPs), that degrade the ECM, allowing cancer cells to invade surrounding tissues. This degradation facilitates the movement of cancer cells through the tissue.

3.Cell Migration: Once the ECM is degraded, cancer cells can migrate. They often use various mechanisms, including amoeboid movement and mesenchymal migration, to move through the tissue. This migration is influenced by various signaling pathways and the tumor microenvironment.

4.Angiogenesis: As tumors grow, they require a blood supply to provide nutrients and oxygen. Tumor cells can stimulate the formation of new blood vessels (angiogenesis) through the release of growth factors like vascular endothelial growth factor (VEGF). This not only supports tumor growth but also provides a route for cancer cells to enter the bloodstream.

5.Invasion into Blood Vessels (Intravasation): Cancer cells can invade nearby blood vessels, allowing them to enter the circulatory system. This step is crucial for metastasis, as it enables cancer cells to travel to distant sites in the body.

6.Survival in Circulation: Once in the bloodstream, cancer cells must survive the immune response and the shear stress of blood flow. They can form clusters with platelets or other cells to evade detection.

7.Extravasation and Colonization: After traveling through the bloodstream, cancer cells can exit the circulation (extravasation) and invade new tissues. They may then establish secondary tumors (metastases) in distant organs.

8.Tumor Microenvironment: The surrounding microenvironment plays a significant role in tumor invasion. Factors such as immune cells, fibroblasts, and signaling molecules can either promote or inhibit invasion and metastasis.
Scientific Papers found: Click to Expand⟱
516- MFrot,  immuno,  MF,    Anti-tumor effect of innovative tumor treatment device OM-100 through enhancing anti-PD-1 immunotherapy in glioblastoma growth
- vitro+vivo, GBM, U87MG
TumCP↓, Apoptosis↑, TumCMig↓, ROS↑, PD-L1↑, TumVol↓, eff↑, *toxicity∅, eff↑, *toxicity∅, Dose↝, tumCV↓, TumCI↓,
8461- Mg,    Effects of Salivary Mg on Head and Neck Carcinoma via TRPM7
- vitro+vivo, SCC, CAL27 - in-vitro, Laryn, FaDu
TumCP↑, TumCMig↑, TumCI↑, TumCG↑, TRPM7↑, Akt↑, mTOR↑, Risk↑, other↝,
8669- MLT,    Melatonin in lung cancer: integrating molecular mechanisms, tumor microenvironment regulation, apoptotic signaling, and therapeutic opportunities
- Review, Lung, NA
Apoptosis↑, ROS↑, Cyt‑c↑, Bcl-2↓, Casp↑, TumCP↓, TumCI↓, angioG↓, Inflam↓, ChemoSen↑, RadioS↑,
8671- MLT,    Targeting mitochondrial metabolism in renal cell carcinoma with melatonin: Preclinical evidence and clinical perspectives
- Review, RCC, NA
OXPHOS↑, Warburg↓, ROS↑, Akt↓, mTOR↓, NF-kB↓, HIF-1↓, VEGF↓, MAPK↓, TumCG↓, angioG↓, TumCI↓, Apoptosis↑, TumAuto↑, Synergy↑, *toxicity↓,
8670- MLT,    Antitumor Effects of Melatonin in Luminal and Triple-Negative Breast Cancer Cells: Metabolic Reprogramming, Redox Regulation, and Cellular Dynamics
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, TumCMig↓, TumCI↓, GAPDH↓, Hif1a↓, citrate↓, ROS↑, lipid-P↑, LDH↓, G6PD↓, MDA?, Catalase↓, GPx↑, GSH↑, *ROS↓,
8690- MLT,    Melatonin inhibits proliferation, migration, and invasion by inducing ROS-mediated apoptosis via suppression of the PI3K/Akt/mTOR signaling pathway in gallbladder cancer cells
- vitro+vivo, Gall, NOZ
TumCG↓, TumCMig↓, TumCI↓, ROS↑, PI3K↓, Akt↓, mTOR↓, eff↓, TumCG↓, tumCV↓,
8686- MLT,  CAP,    Non-thermal plasma-treated melatonin inhibits the biological activity of HCC cells by increasing intracellular ROS levels and reducing RRM2 expression
- in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
Synergy↑, TumCI↓, TumCMig↓, Apoptosis↑, TumCP↓, TumMeta↓, radioP↑, ROS↑, RRM2↓,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
8675- MLT,    Melatonin combined with antineoplastic drugs or natural products for cancer treatment: An update
- Review, Var, NA
ChemoSen↑, TumCP↓, TumCMig↓, CSCs↓, MDR1↓, chemoP?, IL1β↓, IL6↓, IL8↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, Bcl-2↓, Mcl-1↓, IAP1↓, survivin↓, PCNA↓, Ki-67↓, CC(CDKs/cyclins)↓, TumCMig↓, TumCI↓, Fibronectin↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, Synergy↑, Synergy↑, OCT4↓, Nanog↓, ERCC1↓, P-gp/ABCB1↓, EMT↓, Synergy↑, ChemoSen↑,
8906- MOR,    Morin, a avonoid from Moraceae, suppresses growth and invasion of the highly metastatic breast cancer cell line MDA-MB-231 partly through suppression of the Akt pathway
- vitro+vivo, BC, MDA-MB-231
EMT↓, TumCI↓, MMP9↓, ACADS/SCAD↓, p‑Akt↓, AntiTum↓, Dose↝,
8899- MOR,    Morin Inhibits Proliferation, Migration, and Invasion of Bladder Cancer EJ Cells via Modulation of Signaling Pathways, Cell Cycle Regulators, and Transcription Factor-Mediated MMP-9 Expression
- in-vivo, Bladder, NA
TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p‑ERK↑, p‑JNK↓, p‑Akt↓, TumCMig↓, TumCI↓, MMP9↓, AP-1↓, Sp1/3/4↓, NF-kB↓,
8864- MOR,    Morin, a flavonoid from Moraceae, suppresses growth and invasion of the highly metastatic breast cancer cell line MDA-MB‑231 partly through suppression of the Akt pathway
- vitro+vivo, BC, MDA-MB-231
*antiOx↑, *Inflam↓, *AntiCan↑, TumCA↓, TumCI↓, MMP9↓, N-cadherin↓, EMT↓, p‑Akt↓, Akt↓,
8885- MOR,    Anti-Inflammatory and Anti-Migratory Effects of Morin on Non-Small-Cell Lung Cancer Metastasis via Inhibition of NLRP3/MAPK Signaling Pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
IL1β↓, IL18↓, IL6↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, uPAR↓, uPA↓, EMT↓, Fibronectin↓, N-cadherin↓, Vim↓, NLRP3↓, MAPK↓,
8880- MOR,    Morin, a Natural Flavonoid, Activates the PINK1/Parkin Pathway to Induce Mitophagy, Promote Apoptosis, and Suppress Cancer Stemness in Pancreatic Cancer
- in-vitro, PC, NA
tumCV↓, TumCMig↓, TumCI↓, CSCs↓, N-cadherin↓, Snail↓, Zeb1↓, SOX2↓, Nanog↓, OCT4↓, E-cadherin↑, ALDH↓, mtDam↑, MMP↓, compV↓, mt-ROS↑, PINK1↑, PARK2↑, AMPK↑, LC3A↑, LC3B↑, MFN2↓, MitoP↑, Apoptosis↑, Casp3↑, Casp9↑, Cyt‑c↑,
8773- MSM,    Methylsulfonylmethane (organic sulfur) induces apoptosis and decreases invasiveness of prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, DU145
tumCV↓, TumCI↓, Apoptosis↑, TumCCA↑, TumCMig↓, TumCI↓, *toxicity↓,
8944- MushCha,    Inonotus obliquus-derived polysaccharide inhibits the migration and invasion of human non-small cell lung carcinoma cells via suppression of MMP-2 and MMP-9
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑MAPK↓, p‑PI3K↓, p‑Akt↓, COX2/PTGS2↓, NF-kB↓,
8937- MushCha,    Effects of Inonotus obliquus Polysaccharides on Proliferation, Invasion, Migration, and Apoptosis of Osteosarcoma Cells
- in-vitro, OS, MG63 - in-vitro, OS, U2OS
Dose↝, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Akt↓, mTOR↓, NF-kB↓, MMP2↓, MMP9↓,
8961- mushLions,    A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation
- in-vivo, CRC, NA
Apoptosis↑, TRAIL↑, TNFR 1↑, DR5↑, p‑Akt↓, p‑ERK↓, Hif1a↓, PCNA↓, NF-kB↓, TumCI↓, TumCMig↓, TumCP↓,
8960- mushLions,    Recent Advances in Erinacine A: Preparation, Biological Activities, and Biosynthetic Pathway
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *NGF↑, *other↝, *antiOx↑, *Inflam↓, *antiCG↑, *Bacteria↓, *hyperG↝, *AntiDiabetic↑, *AntiCan↑, *neuroG↑, *cognitive↑, *Stroke↓, *IL1β↓, *IL6↓, *TNF-α↓, *RNS↓, *iNOS↓, *MAPK↓, *CHOP/DDIT3↓, TumCD↓, ROS↑, TumCP↓, TumCI↓, ROCK1↓, LIMK2↓, Cofilin↓, PI3K↓, mTOR↓, P70S6K↓, TumCMig↓, TumMeta↓, TGF-β↓, MMP9↓, *AntiAge↑, *RIP1↓, *cl‑Casp8↓, *cl‑Casp3↓, *NRF2↑, *HO-1↑, *SOD1↑,
8957- mushLions,    Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
- Review, Nor, NA
*neuroP↑, *AntiTum↑, *antiOx↑, TumCP↓, *Inflam↓, TumCI↓, Casp↑, *GutMicro↑, *proBDNF↑, *BDNF↑, *Mood↑, *antiD↑, *ANXi↓, *Sleep↑, *cognitive↑, *Imm↑, *NGF↑, *AChE↓, *toxicity↓,
5613- NaHCO3,    The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Acid-Mediated Invasion
- Study, Var, NA
pH↑, TumCG↓, TumCI↓, selectivity↑,
5599- NaHCO3,    Acidity generated by the tumor microenvironment drives local invasion
- in-vivo, BC, MDA-MB-231 - in-vitro, CRC, HCT116
e-pH↑, TumCG↓, TumCI↓, Dose↝,
5607- NaHCO3,    Does Baking Soda Function as a Magic Bullet for Patients With Cancer? A Mini Review
- Review, Var, NA
AntiCan↑, e-pH↑, TumMeta↓, TumCI↓, TumCG↓, CD8+↑, NK cell↑, Remission↑, Synergy↑, ChemoSen↑, ChemoSen↓,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2/PTGS2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
6489- Nimb,    Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model
- in-vivo, Pca, DU145 - in-vivo, Pca, LNCaP
tumCV↓, Apoptosis↑, TumCI↓, TumCMig↓, STAT3↓, ROS↑, TumCG↓, TumMeta↓, TumCCA↑, DNAdam↑, Casp3↑, Casp7↑, cl‑PARP↑, p‑STAT3↓, IL6↓, GSR↓,
4971- Nimb,    Nimbolide, a Neem Limonoid, Is a Promising Candidate for the Anticancer Drug Arsenal
- Review, Var, NA
TumCP↓, Apoptosis↓, TumCI↓, angioG↓, TumMeta↓, Inflam↓,
4976- Nimb,    Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition
- vitro+vivo, PC, NA
ROS↑, Apoptosis↑, TumAuto↑, TumCP↓, TumCMig↓, TumCI↓, EMT↓, Dose↓, selectivity↑, Akt↓, eff↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓,
1911- Nos,    Noscapine inhibits tumor growth in TMZ-resistant gliomas
- in-vitro, GBM, NA - in-vivo, GBM, NA
TumCG↓, TumCI↓, OS↑,
1130- OA,    Oroxylin A Suppresses the Cell Proliferation, Migration, and EMT via NF-κB Signaling Pathway in Human Breast Cancer Cells
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCI↓, TumCMig↓, E-cadherin↑, N-cadherin↓, Vim↓, NF-kB↓,
4628- OLE,    Effects of oleuropein on tumor cell growth and bone remodelling: Potential clinical implications for the prevention and treatment of malignant bone diseases
- in-vitro, Var, NA
chemoPv↑, TumCP↓, angioG↓, TumCI↓, TumMeta↓,
1225- OLST,    Orlistat Induces Ferroptosis in Pancreatic Neuroendocrine Tumors by Inactivating the MAPK Pathway
- vitro+vivo, PC, NA
TumCMig↓, TumCI↓, Ferroptosis↑, MAPK↓,
8429- OM,    Origanum majorana essential oil decreases lung tumor growth and metastasis in vitro and in vivo
- vitro+vivo, NSCLC, A549 - in-vitro, Lung, LNM35
tumCV↓, Casp3↑, Casp7↑, survivin↓, TumCG↓, TumCMig↓, TumCI↓, *toxicity↓,
8449- OM,    Ethanolic extract of Origanum syriacum L. leaves exhibits potent anti-breast cancer potential and robust antioxidant properties
- in-vitro, BC, MDA-MB-231
antiOx↑, ROS↑, TumCP↓, TumCCA↑, p‑p38↑, P21↑, Ki-67↓, eff↓, Apoptosis↑, Casp3↑, STAT3↑, P53↑, TumCMig↓, TumCI↓, FAK↓, iNOS↓, angioG↓,
2381- PBG,    Chinese Poplar Propolis Inhibits MDA-MB-231 Cell Proliferation in an Inflammatory Microenvironment by Targeting Enzymes of the Glycolytic Pathway
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCMig↓, TumCI↓, angioG↓, TNF-α↓, IL1β↓, IL6↓, NLRP3↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, ROS↑, MMP↓,
1231- PBG,    Caffeic acid phenethyl ester inhibits MDA-MB-231 cell proliferation in inflammatory microenvironment by suppressing glycolysis and lipid metabolism
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCMig↓, TumCI↓, MMP↓, TLR4↓, TNF-α↓, NF-kB↓, IL1β↓, IL6↓, IRAK4↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDHA↓, ACC↓, FASN↓, eff↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
4926- PEITC,    PEITC inhibits the invasion and migration of colorectal cancer cells by blocking TGF-β-induced EMT
- in-vitro, CRC, SW48
TumCI↓, TumCMig↓, EMT↓, Smad1↓, AntiCan↑, Snail↓, Slug↓, Zeb1↓, ZEB2↓, TGF-β1↓, Synergy↑, E-cadherin↑, N-cadherin↓, Vim↓,
4931- PEITC,    Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Risk↓, miR-194↑, TumCI↓, MMP2↓, MMP9↓, BMP2↓, *chemoPv↑,
4933- PEITC,    Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification
- vitro+vivo, Lung, H1299 - vitro+vivo, SCC, H226
AntiCan↓, TumCP↓, TumMeta↓, ChemoSen↑, tumCV↓, TumCI↓, TumCMig↓, FTO↓, TLE1↓, Akt↓, NF-kB↓,
1256- PI,    Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
- in-vitro, adrenal, PHEO - in-vivo, NA, NA
Apoptosis↑, ROS↑, TumCMig↓, TumCI↓, EMT↓, angioG↓, Necroptosis↑, MAPK↑, ERK↑,
1131- PI,    Piperlongumine‑loaded nanoparticles inhibit the growth, migration and invasion and epithelial‑to‑mesenchymal transition of triple‑negative breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
TumCG↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, Slug↓, N-cadherin↓, β-catenin/ZEB1↓, SMAD3↓, E-cadherin↑, EMT↓,
5211- PI,    Piperine inhibits colorectal cancer migration and invasion by regulating STAT3/Snail-mediated epithelial-mesenchymal transition
- in-vitro, CRC, NA
TumCMig↓, TumCI↓, EMT↓, Snail↓, STAT3↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
2950- PL,    Overview of piperlongumine analogues and their therapeutic potential
- Review, Var, NA
AntiAg↑, neuroP↑, Inflam↓, NO↓, PGE2↓, MMP3↓, MMP13↓, TumCMig↓, TumCI↓, p38↑, JNK↑, NF-kB↑, ROS↑, FOXM1↓, TrxR1↓, GSH↓, Trx↓, cMyc↓, Casp3↑, Bcl-2↓, Mcl-1↓, STAT3↓, AR↓, DNAdam↑,
2952- PL,    Piperlongumine suppresses bladder cancer invasion via inhibiting epithelial mesenchymal transition and F-actin reorganization
- in-vitro, Bladder, T24/HTB-9 - in-vivo, Bladder, NA
TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, ROS↑, Slug↓, β-catenin/ZEB1↓, Zeb1↓, N-cadherin↓, F-actin↓, GSH↓, EMT↓, CLDN1↓, ZO-1↓,
2961- PL,    Piperlongumine inhibits esophageal squamous cell carcinoma in vitro and in vivo by triggering NRF2/ROS/TXNIP/NLRP3-dependent pyroptosis
- in-vitro, ESCC, KYSE-30
Pyro↑, TumCP↓, TumCMig↓, TumCI↓, ASC↑, cl‑Casp1↑, NLRP3↑, GSDMD↑, ROS↑, NRF2↓, TXNIP↑,
1939- PL,    Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7 - in-vivo, NA, NA
TumCMig↓, TumCI↓, ER Stress↑, selectivity↑, tumCV↓, ROS↑, GSH↓, eff↓, Ca+2↑, MAPK↑, CHOP/DDIT3↑, Dose↝,
4965- PSO,  Cisplatin,    The synergistic antitumor effects of psoralidin and cisplatin in gastric cancer by inducing ACSL4-mediated ferroptosis
- vitro+vivo, GC, HGC27 - vitro+vivo, GC, MKN45
TumCP↓, TumCMig↓, TumCI↓, TumCG↓, *toxicity↓, Synergy↑, Ferroptosis↑, ACSL4↑, GPx4↓, ChemoSen↑, chemoP↑, AntiTum↑, Sepsis↓,
1237- PTS,    Pterostilbene induces cell apoptosis and inhibits lipogenesis in SKOV3 ovarian cancer cells by activation of AMPK-induced inhibition of Akt/mTOR signaling cascade
- in-vitro, Ovarian, SKOV3
TumCMig↓, TumCI↓, MDA↑, ROS↑, BAX↑, Casp3↑, Bcl-2↓, SREBP1/SREBF1↓, FASN↓, AMPK↓, p‑AMPK↑, p‑P53↑, p‑TSC2↑, p‑Akt↓, p‑mTOR↓, p‑S6K↓, p‑4E-BP1↓,

Showing Research Papers: 401 to 450 of 548
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 548

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 2,   antiOx↑, 6,   ARE↓, 1,   Catalase↓, 3,   Copper↑, 1,   ENOX2↓, 1,   Fenton↑, 2,   GPx↓, 1,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 13,   GSH↓, 27,   GSH↑, 2,   GSR↓, 1,   GSTs↑, 1,   H2O2↓, 2,   H2O2↑, 2,   HO-1↓, 5,   HO-1↑, 9,   Iron↑, 4,   i-Iron↑, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 8,   MDA?, 1,   MDA↑, 7,   i-MDA↑, 1,   NADH↓, 2,   NQO1?, 1,   NQO1↑, 1,   NRF2↓, 16,   NRF2↑, 15,   Prx↓, 1,   Prx4↑, 1,   PrxII↓, 1,   PYCR1↓, 1,   ROS↓, 19,   ROS↑, 147,   ROS⇅, 2,   ROS↝, 2,   ROS∅, 1,   i-ROS↓, 1,   i-ROS↑, 1,   mt-ROS↑, 5,   SOD↓, 5,   SOD↑, 2,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 1,   TAC↓, 1,   TAC↑, 1,   TKT↝, 1,   Trx↓, 2,   ox-Trx1↑, 1,   TrxR↓, 5,   TrxR1↓, 3,   xCT/SLC7A11↓, 5,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh∅, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 4,   CDC25↓, 6,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 3,   MFN2↓, 1,   mitResp↑, 1,   Mortalin↓, 1,   mtDam↑, 14,   OCR↓, 6,   OCR↑, 1,   OXPHOS↓, 2,   OXPHOS↑, 5,   mt-OXPHOS↓, 1,   PDH↑, 2,   PDH↝, 1,   PDH∅, 1,   PGC-1α↑, 1,   PINK1↑, 3,   SIRT3↑, 2,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 3,   ACADS/SCAD↓, 1,   ACC↓, 2,   ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 2,   AMPK↓, 1,   AMPK↑, 25,   AMPK↝, 1,   p‑AMPK↑, 5,   ATP↓, 19,   CAIX/CA9↓, 1,   citrate↓, 1,   ECAR↓, 3,   ENO1↓, 1,   FABP4↑, 1,   FABP5/E-FABP↓, 1,   FAM↓, 1,   FASN↓, 6,   FDG↓, 1,   G6PD↓, 5,   GAPDH↓, 2,   GLS↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 11,   GlutMet↓, 1,   Glycolysis↓, 34,   GSK‐3β↓, 10,   GSK‐3β↑, 1,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 1,   Histones↑, 1,   ac‑Histones↑, 1,   HK1↓, 1,   HK2↓, 17,   HMG-CoA↓, 1,   IDH1↑, 1,   lactateProd↓, 11,   lactateProd↑, 1,   LDHA↓, 11,   LDHA∅, 1,   LDL↓, 3,   lipidLev↓, 2,   lipoGen↓, 2,   NADPH↓, 1,   PDHB↓, 1,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 1,   PFK↓, 4,   PFK1↓, 1,   PGK1↓, 2,   PGM1↓, 1,   PIP3↑, 1,   PKM2↓, 19,   PKM2∅, 1,   Pyruv↓, 1,   R5P↝, 1,   RARα↓, 1,   RARβ↑, 1,   RARγ↑, 1,   p‑S6↓, 1,   SCD1↓, 2,   SIRT1↓, 5,   SIRT1↑, 4,   SIRT2↑, 1,   SREBP1/SREBF1↓, 3,   SREBP2↓, 2,   TCA↓, 1,   Warburg↓, 8,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 6,   Apoptosis?, 3,   Apoptosis↓, 7,   Apoptosis↑, 234,   mt-Apoptosis↑, 1,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 1,   BAD↑, 3,   Bak↑, 2,   BAX↓, 1,   BAX↑, 84,   Bax:Bcl2↑, 14,   Bcl-2↓, 99,   Bcl-xL↓, 15,   BIM↑, 2,   BNIP3↑, 1,   Casp↑, 24,   Casp1↓, 1,   Casp1↑, 1,   cl‑Casp1↑, 1,   proCasp1↓, 1,   Casp10↓, 1,   Casp10∅, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 2,   Casp3↑, 94,   cl‑Casp3↑, 24,   Casp7↑, 13,   cl‑Casp7↑, 1,   Casp8↓, 1,   Casp8↑, 23,   Casp8∅, 1,   cl‑Casp8↑, 3,   proCasp8↑, 1,   Casp9↓, 1,   Casp9↑, 58,   p‑Casp9↑, 1,   cl‑Casp9↑, 8,   cFLIP↓, 2,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 47,   Cyt‑c↝, 1,   DR5↑, 11,   DR5∅, 1,   Endon↑, 1,   FADD↑, 3,   FADD∅, 1,   Fas↓, 2,   Fas↑, 11,   FasL↓, 1,   FasL↑, 4,   Ferroptosis↑, 22,   GSDMD↑, 2,   IAP1↓, 5,   IAP2/BIRC3↓, 2,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 7,   Mcl-1↓, 10,   Mcl-1↑, 1,   MDM2↓, 7,   MDM2↑, 1,   MOMP↓, 1,   MOMP↑, 3,   Necroptosis↑, 2,   necrosis↑, 2,   NOXA↑, 2,   P2X7↓, 1,   p38↓, 6,   p38↑, 9,   p‑p38↓, 4,   p‑p38↑, 3,   p‑p38↝, 1,   Paraptosis↑, 1,   PDCD4↑, 1,   PUMA↑, 2,   Pyro↑, 3,   RIP1↓, 1,   survivin↓, 38,   TNFR 1↓, 1,   TNFR 1↑, 1,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↓, 2,   TumCD↑, 9,   TUNEL↑, 1,   XIAP↓, 19,   YAP/TEAD↓, 6,   YAP/TEAD↑, 1,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 122,   Akt↑, 5,   Akt↝, 1,   p‑Akt↓, 44,   p‑Akt↑, 1,   AKT1↓, 4,   AKT3↓, 1,   p‑CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 4,   cMET↓, 1,   p‑cMET↑, 2,   cSrc↓, 1,   EF-1α↓, 1,   EGFR↓, 34,   p‑EGFR↓, 1,   ERK↓, 31,   ERK↑, 7,   ERK↝, 2,   p‑ERK↓, 18,   p‑ERK↑, 1,   p‑ERK↝, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   IGF-1R↓, 2,   IGFR↓, 1,   p‑IGFR↓, 1,   IKKα↓, 10,   IKKα↝, 1,   p‑IKKα↓, 1,   IR↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 6,   JAK↝, 1,   p‑JAK↓, 1,   JAK1↓, 2,   JAK2↓, 11,   p‑JAK2↓, 2,   p‑JAK3↓, 1,   JNK↓, 3,   JNK↑, 10,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 1,   p‑JNK↝, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 27,   MAPK↑, 9,   MAPK↝, 1,   p‑MAPK↓, 2,   p‑MAPK↑, 1,   MEK↓, 4,   p‑MEK↓, 2,   mTOR↓, 67,   mTOR↑, 4,   mTOR↝, 1,   p‑mTOR↓, 12,   mTORC2↓, 2,   mTORC2↑, 1,   NRAS↓, 1,   p42↑, 1,   P70S6K↓, 5,   p‑P70S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PFKFB2↓, 1,   PI3K↓, 83,   PI3K↝, 1,   p‑PI3K↓, 13,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 8,   p‑PKCδ↓, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↑, 22,   PTK2B / PYK2↓, 1,   Raf↓, 3,   c-Raf↓, 1,   RAS↓, 10,   RAS↑, 1,   p‑S6K↓, 1,   SGK1↓, 1,   Sp1/3/4↓, 19,   Src↓, 4,   p‑Src↓, 1,   STAT↓, 6,   p‑STAT↓, 1,   p‑STAT2↓, 1,   STAT3↓, 57,   STAT3↑, 3,   p‑STAT3↓, 10,   p‑STAT3↑, 2,   STAT5↓, 1,   STAT6↓, 3,   THEM4/CTMP↑, 1,   TSC2↑, 2,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2,   ATF4↑, 6,   ATF4↝, 1,   CBP↓, 2,   cJun↓, 6,   cJun↑, 2,   p‑cJun↓, 1,   cMyc↓, 26,   DNMT1↓, 4,   DNMT1↑, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXM1↓, 2,   FOXO↑, 2,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↑, 4,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↑, 1,   ac‑H3↑, 2,   H4↑, 2,   ac‑H4↑, 1,   HATs↓, 5,   HATs↑, 1,   HDAC↓, 11,   HDAC1↓, 4,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC6↓, 2,   HDAC8↓, 1,   HES1↓, 2,   HMTs↓, 1,   HOXB-AS1↓, 1,   JPT1/HN1↓, 1,   KISS1↑, 1,   LINC01116↓, 1,   Matr↓, 1,   METTL7A↑, 1,   miR-107↑, 2,   miR-10b-5p↓, 1,   miR-124-3p↓, 1,   miR-130a↓, 2,   miR-133a-3p↑, 1,   miR-139-5p↑, 3,   miR-145↑, 1,   miR-149↑, 1,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-192-5p↑, 1,   miR-194↑, 1,   miR-200b↑, 1,   miR-205↑, 2,   miR-206↑, 1,   miR-21↓, 8,   miR-223-3p↓, 1,   miR-224↓, 2,   miR-25-5p↓, 1,   miR-29b↑, 1,   miR-301a-3p↓, 1,   miR-30a-5p↑, 1,   miR-340↓, 2,   miR-34a↓, 1,   miR-34a↑, 5,   miR-375↑, 2,   miR-384↑, 1,   miR-422a↑, 2,   miR-542↓, 1,   miR-590-3p↑, 1,   miR-592↑, 1,   miR-7641↓, 1,   miR-99↑, 1,   Myc↓, 1,   Myc↑, 1,   NDRG1↑, 1,   OCT4↓, 12,   other?, 1,   other↓, 2,   other↑, 3,   other↝, 11,   PCAF↓, 1,   PhotoS↑, 2,   RASSF1A↑, 1,   sonoS↑, 1,   SOX2↓, 10,   SOX4↓, 1,   SOX4↑, 1,   SUV39H↓, 1,   TCF-4↓, 1,   TLE1↓, 1,   tumCV↓, 71,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 18,   cl‑CHOP/DDIT3↑, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 4,   p‑eIF2α↑, 2,   ER Stress↑, 27,   Erlin1↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 8,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↑, 1,   e-HSP70/HSPA5↓, 1,   HSP90↓, 13,   HSPs↓, 1,   IRE1↑, 3,   OTUB2↓, 1,   PDI↑, 1,   PERK↑, 9,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↓, 1,   UPR↑, 2,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↓, 1,   ATG5↑, 2,   ATG7↑, 2,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 5,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3A↑, 2,   LC3B↑, 1,   LC3B-II↓, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 7,   LC3s↑, 1,   MitoP↑, 1,   p62↓, 4,   p62↑, 3,   p‑p62↑, 1,   PARK2↑, 3,   RUBCN↓, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 42,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA2↑, 1,   DNAdam↓, 1,   DNAdam↑, 33,   DNArepair↓, 5,   ERCC1↓, 2,   ERCC3↑, 1,   ERCC4/XPF↓, 1,   m-FAM72A↓, 1,   hTERT/TERT↓, 3,   Ku70/XRCC6↓, 1,   p16↑, 2,   P53?, 1,   P53↓, 1,   P53↑, 50,   p‑P53↑, 3,   p73↑, 1,   PARP↓, 3,   PARP↑, 9,   cl‑PARP↑, 42,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 22,   PCNA↑, 1,   POLD1↓, 1,   Telomerase↓, 5,   TOP1↓, 3,   TOP2↓, 2,   TOP2↑, 1,   TP53↑, 2,   XRCC1↓, 1,   γH2AX↑, 5,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 2,   CDK1↓, 9,   CDK1↑, 1,   CDK2↓, 20,   CDK2↑, 3,   CDK4↓, 25,   CDK4↑, 2,   CDK4∅, 1,   CDK4/6↓, 1,   CDK6↓, 10,   CDK6↑, 2,   CDK6∅, 1,   CDK7↓, 1,   cellSen↑, 1,   CHK1↓, 1,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 7,   CycB/CCNB1↓, 15,   cycD1/CCND1↓, 53,   cycD1/CCND1↑, 2,   cycD1/CCND1∅, 1,   CycD3↓, 3,   cycE/CCNE↓, 14,   E2Fs↓, 2,   Ki-67↓, 31,   MAD↓, 1,   P21?, 1,   P21↓, 3,   P21↑, 40,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 10,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 3,   RRM2↓, 1,   Securin↓, 1,   TumCCA↓, 6,   TumCCA↑, 149,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 2,   ALDH↓, 8,   ALDH1A1↓, 1,   Axin2↑, 1,   BMI1↓, 1,   BMP2↓, 1,   BMPs↑, 2,   CD133↓, 11,   CD133↑, 1,   CD24↓, 4,   CD34↓, 1,   cFos↓, 7,   p‑cFos↓, 1,   cMYB↓, 1,   CSCs↓, 38,   Diff↑, 5,   FGF↓, 2,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 13,   HH?, 1,   HH↓, 12,   IGF-1↓, 4,   IGFBP3↓, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Jun↓, 2,   Ki-67↓, 31,   Let-7↑, 1,   LRP6↓, 2,   p‑LRP6↓, 2,   MCM2↓, 1,   mTORC1↓, 5,   Nanog↓, 10,   Nestin↓, 3,   NOTCH↓, 10,   NOTCH↑, 1,   NOTCH1↓, 5,   NOTCH1↝, 1,   NOTCH3↓, 3,   OGFr↑, 2,   p300↓, 3,   PCLAF↓, 1,   Piezo1↑, 2,   PTCH1↓, 3,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 6,   STAT1↓, 1,   p‑STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TOPflash↓, 2,   TumCG?, 2,   TumCG↓, 108,   TumCG↑, 3,   TumCG∅, 1,   TumCP?, 1,   TumCP↓, 242,   TumCP↑, 5,   tyrosinase↓, 1,   URGCP/URG4↓, 1,   WDR72↓, 1,   Wnt↓, 30,   Wnt/(β-catenin)↓, 7,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AGRN↓, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↑, 3,   AP-1↓, 10,   AP-1↝, 1,   ASAP2↓, 1,   Ca+2↑, 20,   CAFs/TAFs↓, 1,   CAFs/TAFs↝, 1,   cal2↑, 2,   Cav1↓, 1,   Cofilin↓, 1,   p‑Cofilin↑, 2,   COL11A1↓, 1,   E-cadherin↓, 6,   E-cadherin↑, 70,   EMT?, 1,   EMT↓, 124,   EMT↑, 4,   EpCAM↓, 3,   F-actin↓, 3,   FAK↓, 14,   FAK↑, 1,   p‑FAK↓, 3,   Fibronectin↓, 7,   GLI2↓, 2,   ITGA2↓, 1,   ITGA5↓, 1,   ITGA6↓, 1,   ITGB1↓, 4,   ITGB3↓, 1,   ITGB4↓, 3,   ITGB6↓, 1,   LAMs↓, 1,   LEF1↓, 2,   LIMK2↓, 1,   LRP1↓, 1,   MALAT1↓, 3,   MET↓, 2,   MET↑, 1,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 5,   MMP13↓, 5,   MMP14↓, 2,   MMP16↓, 2,   MMP17↓, 1,   MMP2?, 1,   MMP2↓, 117,   MMP2↝, 1,   MMP3↓, 8,   MMP7↓, 11,   MMP9?, 1,   MMP9↓, 134,   MMP9↑, 1,   MMP9↝, 1,   MMPs↓, 32,   MTA1↓, 2,   MUC1↓, 1,   MUC4↓, 1,   N-cadherin?, 1,   N-cadherin↓, 53,   NEDD9↓, 3,   p44↑, 1,   PAK1↓, 1,   pax↓, 1,   PDGF↓, 4,   RECK↑, 2,   RHBDD1↓, 1,   Rho↓, 5,   ROCK1↓, 8,   Sharpin↓, 1,   Slug↓, 27,   Smad1↓, 2,   Smad1↑, 1,   Smad1↝, 1,   SMAD2↓, 4,   p‑SMAD2↓, 9,   SMAD3↓, 8,   p‑SMAD3↓, 7,   SMAD4↓, 1,   p‑SMAD4↓, 1,   Snail↓, 44,   Snail↑, 1,   T-cadherin↑, 1,   talin?, 1,   talin↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 18,   TGF-β↑, 3,   TGF-β↝, 1,   TGF-β1↓, 3,   THBS1↓, 1,   TIMP1↓, 1,   TIMP1↑, 7,   TIMP2↓, 2,   TIMP2↑, 9,   TIMP3↑, 2,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 1,   TumCA↓, 10,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 543,   TumCI↑, 7,   TumCMig?, 1,   TumCMig↓, 346,   TumCMig↑, 5,   TumMeta↓, 119,   TumMeta↑, 5,   Twist↓, 16,   Twist↑, 1,   TXNIP↑, 1,   uPA↓, 14,   uPAR↓, 2,   UroPA↓, 1,   Vim?, 1,   Vim↓, 58,   Vim↑, 1,   vinculin↓, 1,   Zeb1↓, 17,   Zeb1↑, 1,   ZEB2↓, 3,   ZEB2↑, 1,   α-SMA↓, 3,   α-SMA↑, 1,   α-tubulin↑, 2,   β-catenin/ZEB1↓, 53,   β-catenin/ZEB1↑, 2,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 96,   angioG↑, 2,   EGR1↓, 1,   EGR4↓, 1,   eNOS↓, 1,   HIF-1↓, 6,   Hif1a↓, 53,   Hif1a↑, 1,   Hif1a↝, 1,   NO↓, 1,   PHDs↑, 1,   TXA2↓, 1,   VEGF↓, 69,   VEGF↑, 1,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 2,   CLDN1↓, 1,   CLDN1↑, 1,   CX43/GJA1↓, 1,   EPR↑, 2,   GLUT1↓, 12,   GLUT1∅, 1,   GLUT3↓, 1,   GLUT3∅, 1,   MMP↓, 65,   MMP↑, 1,   MPT↑, 4,   OATPs↓, 1,   TRPM7↓, 2,   TRPM7↑, 1,   TRPV1↑, 1,   ZO-1↓, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 2,   CD44↓, 13,   CD47↓, 1,   CD8+↑, 5,   p‑cDC2↓, 1,   COX1↓, 3,   COX2/PTGS2↓, 37,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCL12↓, 2,   CXCR2↓, 1,   CXCR4↓, 11,   DR4↑, 7,   DR4∅, 1,   FOXP3↑, 1,   Gal-3↓, 2,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 4,   IFN-γ↑, 1,   Igs↑, 1,   IL1↓, 3,   IL10↓, 1,   IL12↓, 1,   IL12↑, 1,   IL18↓, 2,   IL1α↓, 2,   IL1β↓, 11,   IL2↓, 2,   IL6↓, 26,   IL6↑, 1,   IL8↓, 8,   Imm↑, 11,   Imm↝, 2,   Inflam↓, 34,   Inflam↝, 2,   IRAK4↓, 1,   LIF↑, 1,   LRIG1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 5,   MCT1↓, 1,   MIP2↓, 1,   NF-kB↓, 115,   NF-kB↑, 6,   NF-kB↝, 2,   p‑NF-kB↓, 4,   p‑NF-kB↑, 1,   NFKBIZ/IκBζ↓, 1,   NK cell↑, 3,   NLRP3↓, 5,   NLRP3↑, 2,   p65↓, 5,   p‑p65↓, 2,   PD-1↓, 3,   PD-L1↓, 8,   PD-L1↑, 2,   PGE2↓, 12,   PSA↓, 2,   T-Cell↑, 1,   TCF↓, 2,   Th1 response↑, 1,   TLR2↓, 1,   TLR4↓, 8,   TNF-α↓, 20,   TNF-α↑, 3,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   WFDC10A↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,   pH↑, 1,   e-pH↑, 3,   i-pH↓, 1,   TAMS↓, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↑, 2,   AhR↓, 1,   AR↓, 10,   ER-α36↓, 2,   ERα/ESR1↓, 1,   Estro↝, 1,   EstroRS/ERS↑, 1,   FGF21↓, 1,   NR3C2/MR↑, 2,   PPARα↓, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↑, 5,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   AKR1B10↓, 1,   BioAv↓, 22,   BioAv↑, 23,   BioAv↝, 11,   BioEnh?, 1,   BioEnh↑, 2,   ChemoSen↓, 2,   ChemoSen↑, 107,   CompStab↓, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   DDS↑, 1,   Dose↓, 5,   Dose↑, 3,   Dose↝, 42,   Dose∅, 4,   eff↓, 20,   eff↑, 55,   eff↝, 3,   eff∅, 1,   GSTZ1↓, 1,   Half-Life↓, 7,   Half-Life↑, 2,   Half-Life↝, 7,   MDR1↓, 2,   MRP1/ABCC1↓, 2,   NAT↓, 1,   P-gp/ABCB1↓, 14,   P450↓, 1,   RadioS?, 1,   RadioS↑, 31,   selectivity↑, 62,   Synergy↑, 75,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 2,   ALB↑, 1,   ALP↓, 2,   AR↓, 10,   ascitic↓, 1,   AST?, 1,   AST↓, 1,   BMD↑, 2,   BP↓, 1,   BRCA1↓, 2,   BRCA1↑, 2,   CRP↓, 1,   DBIL↓, 1,   EGFR↓, 34,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↑, 1,   EZH2↓, 1,   Ferritin↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IBIL↓, 1,   IL6↓, 26,   IL6↑, 1,   LDH↓, 7,   LDH↑, 2,   Myc↓, 1,   Myc↑, 1,   NOS2↓, 1,   PD-L1↓, 8,   PD-L1↑, 2,   PSA↓, 2,   TBIL↓, 1,   TG/TAG↓, 1,   TP53↑, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 32,   AntiCan⇅, 1,   AntiCan∅, 1,   antiD↑, 1,   AntiDiabetic↑, 2,   antiNeop↑, 3,   AntiTum↓, 3,   AntiTum↑, 23,   cachexia↓, 1,   cardioP↑, 6,   CardioT↑, 1,   chemoP?, 1,   chemoP↑, 18,   chemoPv↑, 15,   ChemoSideEff↓, 3,   fatigue↓, 2,   FTO↓, 1,   FTO↑, 1,   hepatoP↓, 1,   hepatoP↑, 4,   Mucositis↓, 1,   neuroP↑, 4,   NP/CIPN↓, 1,   OS↑, 11,   Pain↓, 1,   PFS↑, 1,   Pin1↓, 1,   QoL↑, 5,   radioP↑, 6,   Remission↑, 1,   RenoP↑, 2,   Risk↓, 8,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 1,   Symptoms↓, 1,   toxicity?, 1,   toxicity↓, 19,   toxicity↑, 4,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 25,   TumVol∅, 1,   TumW↓, 14,   TumW∅, 1,   Weight∅, 1,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   GutMicro↑, 3,   Sepsis↓, 2,  
Total Targets: 1052

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 51,   Catalase↑, 18,   Fenton↓, 1,   GPx↑, 13,   GPx1↑, 1,   GSH↑, 13,   GSR↑, 1,   GSTs↑, 2,   H2O2↓, 1,   HDL↑, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 11,   hyperG↝, 1,   Iron∅, 1,   Keap1↓, 2,   lipid-P↓, 17,   MDA↓, 12,   MPO↓, 2,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2↑, 23,   RNS↓, 4,   ROS↓, 44,   ROS↑, 1,   SOD↑, 16,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 3,   TBARS↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   HSP60/HSPD1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 6,   AMPK↓, 1,   AMPK↑, 2,   ATP↓, 1,   ATP↑, 1,   cytoP450↓, 1,   glucose↓, 2,   glucose↑, 1,   glucose↝, 2,   GlucoseCon↑, 2,   HMG-CoA↓, 2,   LDL↓, 3,   NAD↓, 1,   NADPH↓, 2,   NADPH↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 3,   Bcl-2↓, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp12↓, 1,   Casp3↓, 5,   cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   Casp9↓, 3,   Cyt‑c↓, 1,   Fas↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 9,   iNOS↑, 1,   p38↓, 1,   RIP1↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 4,   p‑Akt↑, 1,   ERK↓, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IKKα↑, 1,   JAK2↑, 1,   JNK↑, 2,   p‑JNK↓, 1,   MAPK↓, 5,   MAPK↑, 2,   mTOR↓, 2,   mTOR↑, 2,   PI3K↑, 4,   PKCδ↓, 1,   PKCδ↑, 1,   STAT3↑, 2,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   cMyc↓, 1,   HDAC↓, 1,   HOTAIR↑, 1,   other↓, 2,   other↑, 1,   other↝, 5,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   GADD34↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1,   neuroG↑, 1,   TumCP↓, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↝, 1,   EMT↑, 1,   MMP9↓, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TumCI↓, 2,   TumCI∅, 1,   TumCMig↓, 1,   TumCMig∅, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   E-sel↓, 1,   Hif1a↓, 1,   NO↓, 5,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GastroP↑, 2,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 3,   MMP↑, 2,   MUC5AC↓, 1,   VGSC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD25+↑, 1,   CD4+↑, 2,   COX2/PTGS2↓, 12,   FOXP3↑, 1,   HMGB1↓, 1,   IFN-γ↓, 2,   IL1↓, 2,   IL10↓, 3,   IL10↑, 3,   IL12↓, 2,   IL17↓, 1,   IL1β↓, 8,   IL4↓, 1,   IL4↑, 1,   IL6↓, 15,   Imm↓, 1,   Imm↑, 4,   Inflam?, 1,   Inflam↓, 57,   Inflam↑, 2,   IRF3↓, 1,   LPS↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 1,   MyD88↓, 1,   NF-kB↓, 13,   NLRP3↓, 3,   PGE2↓, 5,   TLR2↓, 2,   TLR4↓, 4,   TNF-α↓, 15,   Treg lymp↝, 1,   TRIF↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   Ach↑, 1,   AChE↓, 5,   AChE↑, 1,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 2,   proBDNF↑, 1,   ChAT↑, 1,   MAOA↓, 1,   NGF↑, 2,   TPH1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 1,   Aβ↓, 4,   BACE/β-secretase↓, 1,   tau↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 13,   BioAv↑, 20,   BioAv⇅, 1,   BioAv↝, 9,   BioEnh↑, 1,   CompStab↑, 1,   CompStab↝, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 7,   eff↑, 5,   Half-Life↓, 3,   Half-Life↝, 2,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   ALP↓, 2,   AST↓, 6,   BMD↑, 2,   BP↓, 1,   BUN↓, 1,   creat↓, 1,   CRP↓, 3,   IL6↓, 15,   LDH↓, 2,   SpO2↑, 1,   TG/TAG↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 2,   antiAll↑, 7,   AntiArt↑, 3,   AntiCan↑, 7,   antiCG↑, 1,   antiD↓, 1,   antiD↑, 1,   AntiDiabetic↑, 9,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 3,   ANXi↓, 1,   cardioP↑, 19,   chemoP↑, 1,   chemoPv↑, 2,   cognitive↑, 6,   diuretic↑, 1,   hepatoP↑, 17,   memory↑, 3,   Mood↑, 1,   neuroP?, 1,   neuroP↑, 34,   Obesity↓, 3,   OS↑, 1,   Pain↓, 2,   radioP↑, 3,   RenoP↑, 6,   Risk↓, 1,   Sleep↑, 1,   Stroke↓, 4,   toxicity↓, 23,   toxicity↑, 2,   toxicity↝, 6,   toxicity∅, 7,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↑, 1,   AntiP↑, 2,   AntiViral↑, 6,   Bacteria↓, 11,   GutMicro↑, 10,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 271

Scientific Paper Hit Count for: TumCI, Tumor Cell invasion
21 Curcumin
15 Resveratrol
14 Quercetin
13 Matrine
12 Honokiol
12 Magnolol
12 Shikonin
11 Berberine
11 Fisetin
10 Apigenin (mainly Parsley)
10 EGCG (Epigallocatechin Gallate)
10 Sulforaphane (mainly Broccoli)
9 Thymoquinone
8 Melatonin
8 Eugenol
8 Garcinol
8 Luteolin
7 Ashwagandha(Withaferin A)
7 Betulinic acid
7 Chlorogenic acid
7 Chrysin
7 Licochalcone A
7 Magnetic Fields
6 Metformin
6 Cinnamon
6 Dandelion Root
6 Emodin
6 Formononetin
6 Ginkgetin
6 Piperlongumine
5 Astragalus
5 Gemcitabine (Gemzar)
5 Ferulic acid
5 Hyperoside
5 Lycopene
5 Morin
5 Pterostilbene
4 Artemisinin
4 Baicalein
4 Carvacrol
4 Celastrol
4 Cyclopamine
4 Radiotherapy/Radiation
4 Gambogic Acid
4 Isoliquiritigenin
4 Juglone
4 Nimbolide
4 Phenethyl isothiocyanate
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
4 Urolithin
3 Silver-NanoParticles
3 Alpha-Lipoic-Acid
3 Berbamine
3 Brucea javanica
3 brusatol
3 Capsaicin
3 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
3 Centella asiatica / Gotu kola → asiaticoside
3 chaetocin
3 Zinc
3 Propolis -bee glue
3 Crocetin
3 Copper and Cu NanoParticles
3 Diindolylmethane
3 Evodiamine
3 Gallic acid
3 Paclitaxel/Taxol
3 Genistein (soy isoflavone)
3 Hydrogen Gas
3 Indole-3-carbinol
3 iodine
3 Magnetic Field Rotating
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Bicarbonate(Sodium)
3 Piperine
3 Whole Body Vibration
2 alpha Linolenic acid
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Aspirin
2 Astaxanthin
2 Beta-Caryophyllene
2 Boron
2 Boswellia (frankincense)
2 α-Bisabolol / Chamomile oil
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Celecoxib
2 Hydroxycinnamic-acid
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Dasatinib/Phyrago
2 Deguelin
2 Disulfiram
2 Ellagic acid
2 Ginkgolic acids
2 Ginkgolide B
2 5-fluorouracil
2 Graviola
2 Grapeseed extract
2 Hibiscus sabdariffa
2 HydroxyTyrosol
2 isoflavones
2 isoorientin
2 isoquercitrin
2 itraconazole
2 Kaempferol
2 low dose naltrexone
2 Licorice
2 Linalool
2 Lutein
2 Modified Citrus Pectin
2 Mushroom Chaga, Inonotus obliquus
2 Marjoram (Origanum majorana)
2 Cisplatin
2 salinomycin
2 Sulfasalazine
2 Selenite (Sodium)
2 Aflavin-3,3′-digallate
2 Vitamin C (Ascorbic Acid)
1 1,8-Cineole
1 3-bromopyruvate
1 Ajoene (compound of Garlic)
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Ascorbyl Palmitate
1 Aloe anthraquinones
1 Biochanin A
1 Atorvastatin
1 bempedoic acid
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Butyrate
1 Carnosic acid
1 chitosan
1 Selenium NanoParticles
1 Chlorophyllin
1 Carvone
1 CUSP9
1 Cynaropicrin
1 Cysteamine
1 Dichloroacetate
1 Date Fruit Extract
1 Mistletoe/Viscum album Extracts
1 Ginkgo biloba-EGb 761
1 eicosapentaenoic acid
1 Sorafenib (brand name Nexavar)
1 Fucoidan
1 Galloflavin
1 Ginkgo biloba
1 Geraniol
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Proanthocyanidins
1 Hops (Humulus lupulus)
1 Isobavachalcone
1 phytic acid, Inositol hexakisphosphate
1 Ivermectin
1 Isovitexin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 mebendazole
1 Methyl Jasmonate
1 methylseleninic acid
1 Methyl salicylate / Sweet Birch oil
1 doxorubicin
1 immunotherapy
1 Magnesium
1 Methylsulfonylmethane
1 Noscapine
1 Oroxylin A
1 Oleuropein
1 Orlistat
1 Psoralidin
1 Docetaxel
1 Germacranolide sesquiterpene lactone
1 Rauwolfia serpentina/Indian Snakeroot
1 Salvia miltiorrhiza
1 Terpinen-4-ol / Tea Tree Oil
1 Thymol-Thymus vulgaris
1 Ursolic acid
1 Usnic acid
1 Arsenic trioxide
1 Vitamin K2
1 VitK3,menadione
1 Vitexin
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:324  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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