Akt Cancer Research Results

Akt, PKB-Protein kinase B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes; Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport.

Inhibitors:
-Curcumin: downregulate AKT phosphorylation and signaling.
-Resveratrol
-Quercetin: inhibit the PI3K/AKT pathway.
-Epigallocatechin Gallate (EGCG)
-Luteolin and Apigenin: inhibit AKT phosphorylation


Scientific Papers found: Click to Expand⟱
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
2869- HNK,    Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *motorD↑, *Aβ↓, *p‑tau↓, *cognitive↑, *memory↑, *ERK↑, *p‑Akt↑, *PPARγ↑, *PGC-1α↑, *MMP↑, *mt-ROS↓, *SIRT3↑, *IL1β↓, *TNF-α↓, *GRP78/BiP↓, *CHOP↓, *NF-kB↓, *GSK‐3β↓, *β-catenin/ZEB1↑, *Ca+2↓, *AChE↓, *SOD↑, *Catalase↑, *GPx↑,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2886- HNK,    Liposomal honokiol inhibits non-small cell lung cancer progression and enhances PD-1 blockade via suppressing M2 macrophages polarization
- in-vitro, Lung, A549 - in-vitro, Lung, H460 - in-vivo, NA, NA
eff↑, BioAv↑, eff↑, PI3K↓, Akt↓,
2885- HNK,    Honokiol: a novel natural agent for cancer prevention and therapy
NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp↓,
2897- HNK,    Honokiol Inhibits Proliferation, Invasion and Induces Apoptosis Through Targeting Lyn Kinase in Human Lung Adenocarcinoma Cells
- in-vitro, Lung, PC9 - in-vitro, Lung, A549
TumCP↓, Apoptosis↑, EGFR↓, PI3K↓, Akt↓, STAT3↓, TumCI↓, TNF-α↑, NF-kB↓, VEGF↓, MMP9↓, COX2↓,
2898- HNK,    Honokiol Suppression of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Gastric Cancer Cell Biological Activity and Its Mechanism
- in-vitro, GC, AGS - in-vitro, GC, NCI-N87 - in-vitro, BC, MGC803 - in-vitro, GC, SGC-7901
TumCP↓, Apoptosis↑, TumCI↓, TumCMig↓, HER2/EBBR2↓, TumCCA↑, PI3K↓, Akt↓, MMP9↓, P21↑,
4688- HNK,    Honokiol Suppresses Renal Cancer Cells’ Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling
- vitro+vivo, RCC, A498
CSCs↓, EMT↓, TumCG↓, PI3K↓, Akt↓, mTOR↓, p‑Akt↓, PTEN↑, Wnt↓, β-catenin/ZEB1↓,
4637- HT,    Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells
- in-vitro, Nor, RWPE-1 - in-vitro, Pca, LNCaP - in-vitro, Pca, 22Rv1 - in-vitro, Pca, PC3
selectivity↑, TumCMig↓, p‑Akt↓, ROS↑, CSCs↓, CD44↓, TumCP↓,
4638- HT,    Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation
- in-vitro, CRC, DLD1 - NA, NA, 1-
selectivity↑, ROS↑, Akt↑, FOXO3↓, Apoptosis↑,
4639- HT,    Hydroxytyrosol Induces Apoptosis, Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p27↑, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, p‑Akt↓, p‑STAT3↓, NF-kB↓, AR↓, ROS↑, *BioAv↓, *toxicity∅,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
4642- HT,    Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways
- in-vitro, HCC, HepG2 - NA, NA, Hep3B - NA, NA, SK-HEP-1
TumCP↓, TumCCA↑, Apoptosis↑, Akt↓, NF-kB↓, TumCG↓, angioG↓,
4644- HT,    The Hydroxytyrosol Induces the Death for Apoptosis of Human Melanoma Cells
- in-vitro, Melanoma, NA
tumCV↓, Apoptosis↑, P53↑, γH2AX↑, Akt↓, ROS↑, DNAdam↑,
4212- Hup,    Huperzine A Alleviates Oxidative Glutamate Toxicity in Hippocampal HT22 Cells via Activating BDNF/TrkB-Dependent PI3K/Akt/mTOR Signaling Pathway
- in-vitro, Nor, HT22
*ROS↓, *p‑Akt↓, *p‑mTOR↓, *p‑p70S6↓, *BDNF↑, *Apoptosis↓, *Casp3↓, *Bcl-2↑,
4211- Hup,    Huperzine A ameliorates obesity-related cognitive performance impairments involving neuronal insulin signaling pathway in mice
- in-vitro, NA, NA
*memory↑, *p‑Akt↑, *BACE↓, *cognitive↑,
2180- itraC,    Repurposing Drugs in Oncology (ReDO)—itraconazole as an anti-cancer agent
- Review, Var, NA
Dose↝, toxicity↝, BioAv↑, Half-Life↝, BioAv↑, Dose↝, HH↓, TumAuto↑, Akt↓, mTOR↓, angioG↓, MDR1↓, TumCP↓, eff↑,
1924- JG,    Juglone triggers apoptosis of non-small cell lung cancer through the reactive oxygen species -mediated PI3K/Akt pathway
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Cyt‑c↑, ROS↑, MDA↑, GPx4↓, SOD↓, PI3K↓, Akt↓, eff↓,
5113- JG,    Juglone in Oxidative Stress and Cell Signaling
- Review, Var, NA - Review, AD, NA
ROS↑, Pin1↓, antiOx⇅, *ROS↓, SMAD2↓, GSH↓, lipid-P↑, TumCCA↓, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Ca+2↑, Cyt‑c↑, AntiFungal↑, Bacteria↓, Akt↓,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, eff↑, BAX↑, Fas↑, Pin1↓,
974- JG,    Juglone down-regulates the Akt-HIF-1α and VEGF signaling pathways and inhibits angiogenesis in MIA Paca-2 pancreatic cancer in vitro
- in-vitro, PC, MIA PaCa-2
Hif1a↓, VEGF↓, p‑Akt↓, TumCP↓, TumCI↓,
862- Lae,    Molecular mechanism of amygdalin action in vitro: review of the latest research
- Review, NA, NA
BAX↑, Casp3↑, Bcl-2↓, Akt↓, mTOR↓, p19↑, TumCCA↑, other↓,
2453- LE,    The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors
- Review, Var, NA
HK2↓, PI3K↓, Akt↓, TumCP↓, Glycolysis↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1↓, Hif1a↓, LC3II↑, Beclin-1↑,
2905- LT,    Luteolin blocks the ROS/PI3K/AKT pathway to inhibit mesothelial-mesenchymal transition and reduce abdominal adhesions
- in-vivo, NA, HMrSV5
*ROS↓, *p‑Akt↓, *Vim↓, *E-cadherin↑, *PI3K↓,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑,
3532- Lyco,    Lycopene alleviates oxidative stress via the PI3K/Akt/Nrf2pathway in a cell model of Alzheimer’s disease
- in-vitro, AD, NA
*ROS↓, *PI3K↑, *Akt↑, *NRF2↑, *antiOx↑, *Aβ↓, *Apoptosis↓, *neuroP↑,
3528- Lyco,    The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,
3828- Lyco,    Lycopene alleviates oxidative stress via the PI3K/Akt/Nrf2pathway in a cell model of Alzheimer's disease
- in-vitro, AD, M146L
*ROS↓, *PI3K↑, *Akt↑, *NRF2↓, *antiOx↑, *BACE↓, *MDA↓,
3267- Lyco,    Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways
- in-vitro, Nor, HUVECs
*VEGF↓, *MMP2↓, *uPA↓, *Rac1↑, *TIMP2↑, *p38↓, *Akt↓, *angioG↓,
3274- Lyco,    Lycopene enhances the sensitivity of castration-resistant prostate cancer to enzalutamide through the AKT/EZH2/ androgen receptor signaling pathway
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, C4-2B
Akt↓, EZH2↓,
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2↓, lipid-P↓, GSH↑, NRF2↑,
1126- Lyco,    Lycopene Inhibits Epithelial–Mesenchymal Transition and Promotes Apoptosis in Oral Cancer via PI3K/AKT/m-TOR Signal Pathway
- vitro+vivo, Oral, NA
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EMT↓, PI3K↓, Akt↓, mTOR↓, E-cadherin↓, BAX↑, N-cadherin↓, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Bcl-2↓,
4800- Lyco,    Recent insights on pharmacological potential of lycopene and its nanoformulations: an emerging paradigm towards improvement of human health
- Review, Var, NA
*antiOx↑, Keap1↝, NF-kB↝, NRF2↝, PI3K↝, Akt↝, mTOR↝, *GutMicro↑,
4786- Lyco,    Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines
- in-vitro, BC, MDA-MB-468 - in-vitro, BC, MCF7 - in-vitro, BC, SkBr3
TumCP↓, TumCCA↑, cl‑PARP↑, ERK↑, cycD1/CCND1↓, P21↓, p‑Akt↓, mTOR↓, BAX↑, AntiCan↑, Risk↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, eff↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, eff↑,
4795- Lyco,    Updates on the Anticancer Profile of Lycopene and its Probable Mechanism against Breast and Gynecological Cancer
- Review, BC, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↝, BAX↝, cycD1/CCND1↓, ERK↓, Akt↓, STAT3↓, NRF2↝, NF-kB↓, ITGB1↓, ITGA5↓, FAK↓, MMP9↓, EMT↓,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
4515- MAG,    Magnolol as a Potential Anticancer Agent: A Proposed Mechanistic Insight
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↑, angioG↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, NF-kB↓,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, eff↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
4535- MAG,  5-FU,    Magnolol and 5-fluorouracil synergy inhibition of metastasis of cervical cancer cells by targeting PI3K/AKT/mTOR and EMT pathways
- in-vitro, Cerv, NA
ChemoSen↑, TumCP↓, vinculin↓, TumCA↓, TumCMig↓, TumCI↓, p‑Akt↓, p‑PI3K↓, mTOR↓, E-cadherin↑, β-catenin/ZEB1↑, Snail↓, Slug↓,
4533- MAG,    Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways
- in-vitro, GC, SGC-7901
AntiCan↑, DNAdam↑, Apoptosis↑, TumCCA↑, Bax:Bcl2↑, MMP↓, Casp3↑, PI3K↓, Akt↓,
4519- MAG,    Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiAg↑, *BBB↑, *BioAv↓, BAD↑, Casp3↑, Casp6↑, Casp9↑, JNK↑, Bcl-xL↓, PTEN↑, Akt↓, NF-kB↓, MMP7↓, MMP9↓, uPA↓, Hif1a↓, VEGF↓, FOXO3↓, Ca+2↑, TumCCA↑, ROS↑, Cyt‑c↑,
1089- MAG,    Magnolol potently suppressed lipopolysaccharide-induced iNOS and COX-2 expression via downregulating MAPK and NF-κB signaling pathways
- in-vitro, AML, RAW264.7
p‑IκB↓, NF-kB↓, p‑ERK↓, p‑JNK↓, p‑PI3K↓, p‑Akt↓, iNOS↓, COX2↓,
972- MAG,    Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1α/VEGF signaling pathway in human bladder cancer cells
- vitro+vivo, Bladder, T24/HTB-9
angioG↓, VEGF↓, H2O2↓, Hif1a↓, VEGFR2↓, Akt↓, mTOR↓, P70S6K↓, 4E-BP1↓, TumCG↓, CD31↓, CA↓,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,

Showing Research Papers: 401 to 450 of 663
Prev Page 9 of 14 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 663

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx⇅, 2,   Catalase↓, 3,   CYP1A1↓, 3,   GPx↓, 2,   GPx4↓, 1,   GSH↓, 4,   GSH↑, 1,   GSR↓, 1,   GSTs↓, 1,   H2O2↓, 2,   HO-1↓, 3,   Keap1↝, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 3,   NRF2↑, 2,   NRF2↝, 2,   ROS↓, 2,   ROS↑, 13,   mt-ROS↑, 1,   SOD↓, 5,   SOD2↓, 1,   Trx1↑, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   BOK↑, 1,   CDC2↓, 2,   mitResp↓, 1,   MMP↓, 7,   MPT↑, 1,   mtDam↑, 1,   OCR↓, 1,   OCR↑, 1,   XIAP↓, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   ECAR↓, 1,   FASN↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   LDH↓, 1,   LDL↓, 1,   PPARγ↑, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 32,   Akt↑, 2,   Akt↝, 1,   p‑Akt↓, 10,   APAF1↑, 1,   Apoptosis↑, 19,   BAD↑, 2,   BAX↑, 13,   BAX↝, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 9,   Bcl-xL↓, 2,   BID↑, 1,   Casp↑, 2,   Casp1↓, 1,   cl‑Casp12↑, 1,   Casp3↑, 13,   cl‑Casp3↑, 2,   Casp6↑, 1,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 8,   cl‑Casp9↑, 2,   proCasp9↓, 1,   cFLIP↓, 2,   Cyt‑c↑, 10,   DR5↑, 5,   FADD↑, 1,   Fas↑, 5,   FasL↑, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 3,   iNOS↓, 2,   JNK↑, 3,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 5,   MAPK↑, 1,   Mcl-1↓, 3,   MDM2↓, 2,   p‑MDM2↓, 1,   NAIP↓, 1,   NICD↓, 1,   p27↓, 1,   p27↑, 5,   p‑p38↑, 1,   survivin↓, 2,   Telomerase↓, 2,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,   HER2/EBBR2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   H3↓, 1,   H4↓, 1,   other↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↑, 2,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↑, 1,   PERK↑, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 2,   BNIP3↑, 1,   LC3B-II↑, 1,   LC3II↑, 2,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 6,   P53↑, 7,   P53↝, 1,   PARP↑, 1,   cl‑PARP↑, 4,   PCNA↓, 3,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 11,   CDK4↓, 6,   cycA1/CCNA1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 10,   CycD3↓, 1,   cycE/CCNE↓, 4,   p19↑, 1,   P21↓, 1,   P21↑, 9,   TumCCA↓, 2,   TumCCA↑, 18,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   CD133↓, 1,   CD34↓, 1,   CD44↓, 2,   cFos↑, 1,   p‑cMET↑, 1,   CSCs↓, 3,   EMT↓, 9,   EMT↑, 1,   ERK↓, 5,   ERK↑, 1,   p‑ERK↓, 2,   FOXM1↓, 1,   FOXO3↓, 2,   GSK‐3β↓, 2,   p‑GSK‐3β↓, 1,   HDAC↓, 2,   HH↓, 1,   IGF-1↓, 1,   mTOR↓, 18,   mTOR↝, 1,   p‑mTOR↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 2,   P70S6K↓, 1,   PI3K↓, 19,   PI3K↝, 1,   p‑PI3K↓, 4,   PTEN↓, 2,   PTEN↑, 3,   RAS↓, 4,   RAS↑, 1,   Shh↓, 1,   p‑Src↓, 1,   STAT3↓, 5,   p‑STAT3↓, 4,   p‑STAT6↓, 1,   TAZ↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 7,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   Akt2↓, 1,   AXL↓, 1,   CA↓, 1,   Ca+2↑, 6,   CD31↓, 1,   Cdc42↓, 1,   CEA↓, 1,   CLDN1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 8,   FAK↓, 4,   ITGA5↓, 1,   ITGB1↓, 2,   Ki-67↓, 2,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 1,   MMP2↓, 8,   MMP7↓, 3,   MMP9↓, 11,   MMP9↑, 1,   MMPs↓, 3,   N-cadherin↓, 8,   PDGF↓, 2,   PKCδ↓, 1,   Rac1↓, 1,   Rho↓, 1,   Rho↑, 1,   ROCK1↑, 1,   Slug↓, 1,   SMAD2↓, 1,   Snail↓, 5,   TIMP1↑, 1,   TIMP2↑, 1,   TumCA↓, 1,   TumCI↓, 14,   TumCMig↓, 10,   TumCMig↑, 1,   TumCP↓, 19,   TumMeta↓, 4,   Twist↓, 5,   Tyro3↓, 1,   uPA↓, 1,   Vim↓, 3,   Vim↑, 1,   vinculin↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 4,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 12,   ATF4↑, 1,   EGFR↓, 5,   EGFR↑, 1,   p‑EGFR↓, 1,   Hif1a↓, 8,   NO↝, 1,   VEGF↓, 13,   VEGFR2↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   COX2↓, 5,   CXCR4↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 1,   IKKα↓, 1,   IL1↓, 1,   IL1β↓, 1,   IL2↑, 1,   IL6↓, 3,   Inflam↓, 1,   p‑IκB↓, 1,   JAK1↓, 1,   JAK2↓, 1,   NF-kB↓, 22,   NF-kB↝, 1,   p‑NF-kB↑, 1,   p‑p65↓, 1,   PD-1↓, 1,   PGE2↓, 2,   PSA↓, 1,   TNF-α↓, 3,   TNF-α↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 4,   CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 1,   ChemoSen↓, 1,   ChemoSen↑, 7,   CYP1A2↓, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 7,   Half-Life↝, 3,   MDR1↓, 2,   P450↓, 1,   RadioS↑, 4,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 4,   BMPs↑, 2,   CEA↓, 1,   EGFR↓, 5,   EGFR↑, 1,   p‑EGFR↓, 1,   EZH2↓, 1,   FOXM1↓, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 3,   Ki-67↓, 2,   LDH↓, 1,   NSE↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   AntiTum↑, 1,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 4,   chemoPv↑, 1,   Pin1↓, 2,   Risk↓, 1,   toxicity↓, 1,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 1,  
Total Targets: 310

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 13,   Catalase↑, 5,   GPx↑, 3,   GSH↑, 4,   GSR↑, 3,   GSTA1↑, 1,   GSTs↓, 1,   GSTs↑, 2,   H2O2↓, 1,   HO-1↑, 2,   Keap1↑, 1,   lipid-P↓, 2,   MDA↓, 1,   MPO↓, 1,   NRF2↓, 1,   NRF2↑, 6,   ROS↓, 14,   mt-ROS↓, 1,   SIRT3↑, 2,   SOD↑, 6,   TAC↑, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 2,   PGC-1α↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   LDHA↑, 1,   NADPH↓, 1,   PPARγ↓, 1,   PPARγ↑, 3,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Akt↑, 2,   p‑Akt↓, 2,   p‑Akt↑, 2,   Apoptosis↓, 2,   Bcl-2↑, 1,   Casp3↓, 4,   iNOS↓, 2,   MAPK↓, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑p70S6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↓, 1,   GRP78/BiP↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   ERK↑, 1,   GSK‐3β↓, 1,   p‑mTOR↓, 1,   PI3K↓, 1,   PI3K↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   Ca+2↓, 1,   E-cadherin↑, 1,   MMP2↓, 1,   Rac1↑, 1,   p‑Rac1↓, 1,   Rho↓, 1,   TGF-β1↑, 1,   TIMP2↑, 1,   uPA↓, 1,   Vim↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   NO↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   P-gp↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 4,   IKKα↑, 1,   IL10↓, 1,   IL10↑, 2,   IL1β↓, 3,   IL6↓, 2,   Inflam↓, 7,   Inflam↑, 1,   NF-kB↓, 5,   PGE2↓, 2,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   AChE↑, 1,   BDNF↑, 2,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 4,   BACE↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 2,   BioAv↝, 2,   eff↑, 1,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   GutMicro↑, 1,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 5,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 4,   motorD↑, 1,   neuroP↑, 10,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 2,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 3,  
Total Targets: 110

Scientific Paper Hit Count for: Akt, PKB-Protein kinase B
39 Curcumin
28 Quercetin
24 Thymoquinone
24 Apigenin (mainly Parsley)
21 Baicalein
19 Resveratrol
16 Berberine
16 Chrysin
15 Fisetin
14 Shikonin
13 Alpha-Lipoic-Acid
12 Emodin
11 Magnetic Fields
11 Lycopene
11 Sulforaphane (mainly Broccoli)
10 Ashwagandha(Withaferin A)
10 Eugenol
10 Honokiol
9 Carvacrol
9 EGCG (Epigallocatechin Gallate)
9 Magnolol
8 Silver-NanoParticles
8 Cisplatin
8 Artemisinin
8 Beta-Caryophyllene
8 Rosmarinic acid
8 Capsaicin
8 Deguelin
8 Ellagic acid
8 Piperlongumine
8 Urolithin
7 Propolis -bee glue
7 Cinnamon
7 Citric Acid
7 HydroxyTyrosol
7 Nimbolide
7 Phenethyl isothiocyanate
7 Silymarin (Milk Thistle) silibinin
6 5-fluorouracil
6 Celastrol
6 Dandelion Root
6 Luteolin
5 Allicin (mainly Garlic)
5 Anethole/trans-Anethole
5 Carnosic acid
5 Chlorogenic acid
5 Ursolic acid
5 Naringin
5 Piperine
5 Selenite (Sodium)
4 Coenzyme Q10
4 Astragalus
4 Chemotherapy
4 brusatol
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 Celecoxib
4 Ferulic acid
4 Gambogic Acid
4 Juglone
4 Magnetic Field Rotating
4 Vitamin K2
3 1,8-Cineole
3 doxorubicin
3 Gemcitabine (Gemzar)
3 Paclitaxel
3 Astaxanthin
3 Baicalin
3 Betulinic acid
3 Bufalin/Huachansu
3 Brucea javanica
3 Bacopa monnieri
3 Boron
3 Caffeic acid
3 Thymol-Thymus vulgaris
3 Cucurbitacin
3 Radiotherapy/Radiation
3 diet FMD Fasting Mimicking Diet
3 Eurycomanone
3 Gallic acid
3 Garcinol
3 Pterostilbene
3 Sanguinarine
3 Aflavin-3,3′-digallate
2 3-bromopyruvate
2 Auranofin
2 Berbamine
2 Biochanin A
2 Bromelain
2 Sorafenib (brand name Nexavar)
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Centella asiatica / Gotu kola → asiaticoside
2 Hydroxycinnamic-acid
2 CUSP9
2 Diclofenac
2 diet Methionine-Restricted Diet
2 D-limonene
2 Geraniol
2 Ginseng
2 Hydrogen Gas
2 Huperzine A/Huperzia serrata
2 Melatonin
2 Myricetin
2 Oleuropein
2 Plumbagin
2 Parthenolide
2 α-Santalol/Sandalwood oil
1 Camptothecin
1 chemodynamic therapy
1 Acetyl-l-carnitine
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Aloe anthraquinones
1 almonertinib
1 borneol
1 Caffeine
1 Trastuzumab
1 hydroxychloroquine
1 Carnosine
1 Chocolate
1 Cichoric acid / Chicoric acid
1 immunotherapy
1 Vitamin E
1 Crocetin
1 gefitinib, erlotinib
1 Photodynamic Therapy
1 Dichloroacetophenone(2,2-)
1 Docosahexaenoic Acid
1 Dipyridamole
1 Atorvastatin
1 Disulfiram
1 Copper and Cu NanoParticles
1 Fucoidan
1 Ai-Tong-An-Gao-Ji
1 flavonoids
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Grapeseed extract
1 itraconazole
1 Laetrile B17 Amygdalin
1 Licorice
1 MCToil
1 Metformin
1 Neem
1 nelfinavir/Viracept
1 Docetaxel
1 Oleocanthal
1 Proanthocyanidins
1 sericin
1 Psoralidin
1 salinomycin
1 Selenate
1 Selenium NanoParticles
1 Formononetin
1 acetazolamide
1 statins
1 Tomatine
1 Turmerones
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Wogonin
1 Zinc
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:4  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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