angioG Cancer Research Results

angioG, angiogenesis: Click to Expand ⟱
Source:
Type:
Process through which new blood vessels.
Angiogenesis, the process of new blood vessel formation from pre-existing vessels, plays a crucial role in cancer progression and metastasis. Tumors require a blood supply to grow beyond a certain size and to spread to other parts of the body.
Vascular Endothelial Growth Factor (VEGF): VEGF is one of the most important pro-angiogenic factors. It stimulates endothelial cell proliferation and migration, leading to the formation of new blood vessels. Many tumors overexpress VEGF, which correlates with poor prognosis.
Hypoxia-Inducible Factor (HIF): In response to low oxygen levels (hypoxia), tumors can activate HIF, which in turn promotes the expression of VEGF and other angiogenic factors. This mechanism allows tumors to adapt to their microenvironment and sustain growth.
-Tumour development and progression beyond a size of few millimetres‐cubed crucially depends on the onset of angiogenesis, that is, the ‘angiogenic switch’
Scientific Papers found: Click to Expand⟱
883- RES,    Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy
- Review, Var, NA
HDAC↓, TumCCA↑, Apoptosis↑, angioG↓, ROS↑,
7150- RES,    Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
- Review, Var, NA
AntiTum↑, PI3K↓, Akt↓, *AntiAge↑, *SIRT1↑, *lipid-P↓, *ROS↓, *BioAv↓, *NRF2↑, *HO-1↑, SOD↑, HDAC1↓, PTEN↑, P53↑, TumCCA↑, TumCI↓, TumMeta↓, EMT↓, MMPs↓, MMP9↓, angioG↓, VEGF↓, EGFR↓, FGF21↓, HIF-1↓, *neuroP↑, *cardioP↑, BMPs↑, ROS↑, Vim↓, N-cadherin↓, MMP3↓, MMP13↓, E-cadherin↑, Ki-67↓,
3618- RosA,    Antioxidant and Antimicrobial Properties of Rosemary (Rosmarinus officinalis, L.): A Review
- Review, AD, NA
*hepatoP↑, *antiOx↑, *angioG↓, *other↓, *Inflam↓, *ROS↓, *IronCh↑, *lipid-P↓, *antiOx↑,
3007- RosA,    Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action
- Review, Nor, NA
*ROS↓, *lipid-P↓, *Inflam↓, *neuroP↑, *angioG↓, *Synergy↑, *AST↓, *ALAT↓, *GSSG↓, *eNOS↓, *iNOS↓, *NO↓, *NF-kB↓, *MMP2↓, *MDA↓, *TNF-α↓, *GSH↑, *SOD↑, *IL6↓, *PGE2↓, *COX2/PTGS2↓, *mTOR↑,
3006- RosA,    Rosmarinic acid attenuates glioblastoma cells and spheroids’ growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229
TumCG↓, EMT↓, SIRT1↓, FOXO1↓, NF-kB↓, angioG↓, ROS↓, PTEN↓, PI3K↓, Akt↓, *Inflam↓, *cardioP↑, *hepatoP↑, *neuroP↑, Warburg↓,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
3639- Sage,    Pharmacological properties of Salvia officinalis and its components
- Review, AD, NA - Review, Var, NA
AntiCan↑, *Inflam↓, *antiOx↑, *cognitive↑, *memory↑, *LDL↓, TumCG↓, MAPK↓, ROS↓, NF-kB↓, COX2/PTGS2↓, angioG↓, *AST↓, *ALAT?,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27/CDKN1B↑, CHOP/DDIT3↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
6441- SAO,    Sandalwood Album Oil as a Botanical Therapeutic in Dermatology
- Review, PSA, NA
*Inflam↓, *eff↑, *5LO↓, *DPPH↓, *hepatoP↑, *ROS↓, *PGE2↓, *IL1β↓, *IL17↓, *PDE4↓, *tyrosinase↓, *AntiFungal↑, angioG↓, TumCG↓, DNAdam↑, *Snail↑, *Twist↑, *Vim↑, *EMT↓, *toxicity↓,
6442- SAO,    Medicinal properties of alpha-santalol, a naturally occurring constituent of sandalwood oil: review
- Review, RCC, NA
AntiTum↑, Apoptosis↑, TumCCA↑, *Inflam↓, selectivity↑, tumCV↓, Casp8↓, Casp9↓, Casp6↓, Casp3↓, cl‑PARP↑, angioG↓, VEGFR2/KDR/Flk1↓, Akt↑, mTOR↓, TumCG↓, *GSTs↑, *antiOx↑, *ROS↓,
6220- Se,  CUR,  Rad,    Selenium-Curcumin-PEG Nanoparticles Radiosensitization for Intensity-Modulated Radiation Therapy of Lung Tumor Cells: In Vitro Synergistic Combination Therapy
- in-vitro, Lung, A549
RadioS↑, TumCD↑, ROS↑, Imm↑, angioG↓, BioAv↑, TumCP↓, Apoptosis↓, TumMeta↓, CompStab↑,
4603- SeNPs,    Therapeutic applications of selenium nanoparticles
- Review, Var, NA
AntiCan↑, Imm↑, *AntiDiabetic↑, *antiOx↑, *Inflam↓, ROS↑, ER Stress↑, DNAdam↑, *toxicity↓, *eff↑, *BioAv↑, selectivity↑, TumCCA↑, Risk↓, *lipid-P↓, *TNF-α↓, *CRP↓, TumMeta↓, angioG↓, selectivity↑, Synergy↑, *Synergy↑,
4469- SeNPs,    Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential
- Review, Var, NA
antiOx↑, selectivity↑, eff↑, AntiCan↑, Apoptosis↑, ROS↑, MMP↓, Casp3↑, Casp9↑, AntiTum↑, TumCG↓, TumMeta↓, angioG↓, Cyt‑c↑, DNAdam↑, RadioS↑, BBB↑, *toxicity↓, ChemoSen↑,
3182- SFN,    Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells
- in-vitro, AML, NA
Prx↓, AQPs↓, NOX↓, tumCV↓, AntiCan↑, cardioP↑, neuroP↑, Inflam↓, chemoPv↑, angioG↓, TumMeta↓, selectivity↑, ROS↓,
963- SFN,    Sulforaphane inhibits hypoxia-induced HIF-1α and VEGF expression and migration of human colon cancer cells
- in-vitro, CRC, HCT116 - in-vitro, GC, AGS
Hif1a↓, VEGF↓, angioG↓, Akt∅, ERK∅,
2556- SFN,    The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review
- Review, Var, NA
chemoPv↑, HDAC↓, Hif1a↓, angioG↓, CYP1A1↓, ChemoSen↑, BioAv↑,
1469- SFN,    Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vivo, Pca, NA
Synergy↑, ROS↑, MMP↓, Casp3↑, Casp9↑, DR4↑, DR5↑, BAX↑, Bak↑, BIM↑, NOXA↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, eff↓, TumCG↓, TumCP↓, eff↑, NF-kB↓, PI3K↓, Akt↓, MEK↓, ERK↓, angioG↓, FOXO3↑,
1458- SFN,    Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
- Review, Bladder, NA
HDAC↓, eff↓, TumW↓, TumW↓, angioG↓, *toxicity↓, GutMicro↝, AntiCan↑, ROS↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8∅, cl‑PARP↑, TRAIL↑, DR5↑, eff↓, NRF2↑, ER Stress↑, COX2/PTGS2↓, EGFR↓, HER2/EBBR2↓, ChemoSen↑, NF-kB↓, TumCCA?, p‑Akt↓, p‑mTOR↓, p70S6↓, p19↑, P21↑, CD44↓, CSCs↓,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, Synergy↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
1484- SFN,    Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action
- Review, Var, NA - Review, AD, NA
neuroP↑, AntiCan↑, NRF2↑, HDAC↓, eff↑, *ROS↓, neuroP↑, HDAC↓, *toxicity∅, BioAv↑, eff↓, cycD1/CCND1↓, CDK4↓, p‑RB1↓, Glycolysis↓, miR-30a-5p↑, TumCCA↑, TumCG↓, TumMeta↓, eff↑, ChemoSen↑, RadioS↑, CardioT↓, angioG↓, Hif1a↓, VEGF↓, *BioAv?, *Half-Life∅,
1732- SFN,    Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells
- in-vitro, BC, MCF7 - in-vitro, BC, SUM159 - in-vivo, NA, NA
TumCD↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, *BioAv↑, angioG↓, VEGF↓, Hif1a↓, MMP2↓, MMP9↓, Casp3↑, *Half-Life∅,
1729- SFN,    Discovery and development of sulforaphane as a cancer chemopreventive phytochemical
- Review, Nor, NA
eff↑, angioG↓, VEGF↓, MMP9↓, MMP2↓,
3306- SIL,  Rad,    Radioprotective and radiosensitizing properties of silymarin/silibinin in response to ionizing radiation
- Review, Var, NA
radioP↑, RadioS↑, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, DNAdam↓, ROS↑, *ROS↓, *Inflam↓,
3314- SIL,    Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *Half-Life↑, *ROS↓, *GSH↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *IFN-γ↓, *IL2↓, *IL4↓, *NF-kB↓, *iNOS↓, *OATPs↓, *OCT4↓, *Inflam↓, *PGE2↓, MMPs↓, VEGF↓, angioG↓, STAT3↓, *ALAT↓, *AST↓, Dose↝,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, Synergy↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
3323- SIL,    Anticancer therapeutic potential of silibinin: current trends, scope and relevance
- Review, Var, NA
Inflam↓, angioG↓, antiOx↑, TumMeta↓, TumCP↓, TumCCA↑, TumCD↑, α-SMA↓, p‑Akt↓, p‑STAT3↓, COX2/PTGS2↓, IL6↓, MMP2↓, HIF-1↓, Snail↓, Slug↓, Zeb1↓, NF-kB↓, p‑EGFR↓, JAK2↓, PI3K↓, PD-L1↓, VEGF↓, CDK4↓, CDK2↓, cycD1/CCND1↓, E2Fs↓,
3326- SIL,    Silymarin suppresses proliferation of human hepatocellular carcinoma cells under hypoxia through downregulation of the HIF-1α/VEGF pathway
- in-vitro, Liver, HepG2 - in-vitro, Liver, Hep3B
*hepatoP↑, chemoPv↑, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, Hif1a↓, VEGF↓, angioG↓,
964- SIL,    Silibinin inhibits hypoxia-induced HIF-1α-mediated signaling, angiogenesis and lipogenesis in prostate cancer cells: In vitro evidence and in vivo functional imaging and metabolomics
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, 22Rv1
TumCP↓, Hif1a↓, NADPH↓, angioG↓, FASN↓, ACC↓,
2188- SK,    Molecular mechanism of shikonin inhibiting tumor growth and potential application in cancer treatment
- Review, Var, NA
ROS↑, EGFR↓, PI3K↓, Akt↓, angioG↓, Apoptosis↑, Necroptosis↑, GSH↓, Ca+2↓, MMP↓, ERK↓, p38↑, proCasp3↑, eff↓, VEGF↓, FOXO3↑, EGR1↑, SIRT1↑, RIP1↑, RIP3↑, BioAv↓, NF-kB↓, Half-Life↓,
1688- SSE,    Potential Role of Selenium in the Treatment of Cancer and Viral Infections
- Review, Var, NA
IL2↑, INF-γ↑, Th1 response↑, Th2↑, Dose↑, AntiCan∅, Risk↑, chemoP↑, Hif1a↓, VEGF↓, selectivity↑, *GADD45A↑, NRF2↓, *NRF2↑, ChemoSen↑, angioG↓, PrxI↓, ChemoSideEff↓, Synergy↑,
5074- SSE,    Application of Sodium Selenite in the Prevention and Treatment of Cancers
- Review, Var, NA
Imm↑, angioG↑, DNArepair↑, NK cell↑, ROS↑, AntiCan↑, selectivity↑, ER Stress↑, TumAuto↑, necrosis↑, toxicity↝, Dose↑,
5082- SSE,    Rationale for the treatment of cancer with sodium selenite
- Review, Var, NA
Risk↑, antiOx↑, ROS↑, Imm↑, NK cell↑, angioG↓, toxicity↓,
5089- SSE,  Se,    Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line
- in-vitro, Pca, LNCaP
ROS↑, mtDam↑, TumCD↑, Apoptosis↑, TumCCA↑, Trx↓, angioG↓, GSH⇅, NADPH↓, GPx↑,
4739- SSE,  Chemo,  Rad,    Therapeutic Benefits of Selenium in Hematological Malignancies
- Review, Var, NA
ChemoSen↑, radioP↑, QoL↑, Risk↓, *selenoP↑, TumCP↓, Inflam↓, ChemoSen↑, TumCCA↑, Apoptosis↑, angioG↓, Dose⇅, ROS↑, eff↑, Risk↓, eff∅, CSCs↓, ROS↑,
1202- Tb,    The influence of theobromine on angiogenic activity and proangiogenic cytokines production of human ovarian cancer cells
- in-vitro, Ovarian, NA
angioG↓, VEGF↓,
5337- TFdiG,    Theaflavin 3,3'-digallate suppresses metastasis and reduces insulin-like growth factor-1-induced cancer stemness and invasiveness in human melanoma cells
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, A2058
TumCMig↓, TumCI↓, MMPs↓, ALDH↓, CSCs↓, ABCG2↓, CD44↓, CXCR4↓, TumCG↓, angioG↓, TumMeta↓,
6175- TM,    Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1
- vitro+vivo, Var, NA
SOD1↓, TumCP↓, angioG↓,
6174- TM,    Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse
- Trial, BC, NA
OS↑, toxicity↓, AntiTum↑, Copper↓, angioG↓,
6172- TM,    Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer
- Trial, Pca, NA
Copper↓, angioG∅, eff∅,
1933- TQ,    Thymoquinone: potential cure for inflammatory disorders and cancer
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCCA↑, ROS↑, angioG↓, Apoptosis↑, Casp↑, ChemoSen↑, eff↝,
1935- TQ,    Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
- Review, OS, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, ROS↑, P53↑, Twist↓, E-cadherin↑, N-cadherin↓, NF-kB↓, IL8↓, XIAP↓, Bcl-2↓, STAT3↓, MAPK↓, PI3K↓, Akt↓, ERK↓, MMP2↓, MMP9↓, *ROS↓, HO-1↑, selectivity↑, TumCG↓,
2138- TQ,    Thymoquinone has a synergistic effect with PHD inhibitors to ameliorate ischemic brain damage in mice
- in-vivo, Nor, NA
*Hif1a↑, *VEGF↑, *TrkB↑, *PI3K↑, *angioG↑, *neuroG↑, *motorD↑,
2094- TQ,    Cytotoxicity of Nigella sativa Extracts Against Cancer Cells: A Review of In Vitro and In Vivo Studies
- Review, Var, NA
ROS↑, angioG↓, TumMeta↓, VEGF↓, MMPs↓, P53↑, BAX↑, Casp↑, Bcl-2↓, survivin↓, *ROS↓, ChemoSen↑, chemoP↑, MDR1↓, BioAv↓, BioAv↑,
2102- TQ,    A review on therapeutic potential of Nigella sativa: A miracle herb
- Review, Var, NA
angioG↓, NF-kB↓, PPARγ↓, Bcl-2↓, Bcl-xL↓, MUC4↓, cJun↑, p38↑, P21↑, HDAC↓, *radioP↑, hepatoP↑,
3408- TQ,    Thymoquinone: A small molecule from nature with high therapeutic potential
- Review, AD, NA - Review, Park, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *Inflam↓, *antiOx↑, ChemoSen↑, Synergy↑, Synergy↑, TumCP↓, TumCCA↑, angioG↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3425- TQ,    Advances in research on the relationship between thymoquinone and pancreatic cancer
- in-vitro, PC, NA
Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2/PTGS2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1/CCL2↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,

Showing Research Papers: 401 to 450 of 463
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 463

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,   NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 14,   antiOx⇅, 1,   ARE↓, 1,   Catalase↓, 2,   Catalase↑, 3,   Copper↓, 2,   Fenton↑, 4,   frataxin↑, 1,   GPx↑, 4,   GPx4↓, 4,   GSH↓, 28,   GSH↑, 3,   GSH⇅, 1,   GSH/GSSG↓, 1,   GSR↓, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   H2O2↓, 1,   H2O2↑, 4,   HO-1↓, 6,   HO-1↑, 10,   HO-2↓, 1,   Iron↑, 2,   Iron∅, 1,   Keap1↓, 2,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 15,   MDA↓, 3,   MDA↑, 2,   NOX↓, 1,   NQO1↑, 1,   NRF2↓, 17,   NRF2↑, 17,   Prx↓, 2,   Prx4↑, 1,   PrxI↓, 1,   PrxII↓, 1,   PYCR1↓, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 18,   ROS↑, 176,   ROS⇅, 3,   ROS↝, 5,   i-ROS↑, 1,   mt-ROS↑, 5,   SOD↓, 5,   SOD↑, 7,   SOD1↓, 2,   SOD1↑, 1,   SOD2↑, 2,   TBARS↑, 1,   Thiols↓, 3,   Trx↓, 2,   ox-Trx1↑, 1,   TrxR↓, 6,   TrxR1↓, 2,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

ATOX1↝, 1,   Ferritin↓, 2,   IronCh↑, 2,   NCOA4↑, 1,   Tf↓, 2,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR-ABL↓, 1,   CDC2↓, 3,   CDC25↓, 6,   compI↓, 3,   compII↓, 2,   EGF↓, 5,   ETC↓, 5,   HSP60/HSPD1↓, 2,   mitResp↓, 2,   Mortalin↓, 1,   mtDam↓, 1,   mtDam↑, 17,   OCR↓, 5,   OCR↑, 2,   OXPHOS↓, 2,   OXPHOS↑, 3,   PDH↓, 1,   PINK1↑, 1,   SDH↓, 1,   SIRT3↓, 1,   VDAC1↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 3,   AApath↓, 1,   ACC↓, 1,   ACC↑, 1,   ALAT↓, 3,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 17,   p‑AMPK↑, 1,   p‑AMT/GCST/T-protein↑, 1,   ARG↓, 1,   ATP↓, 15,   mt-ATP↓, 2,   CAIX/CA9↓, 1,   CBS↑, 1,   citrate↓, 1,   CPT1A↓, 1,   CYP4A/CYP4A11/CYP4A22↓, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 1,   FABP5/E-FABP↓, 1,   FASN↓, 5,   FASN↑, 1,   GAPDH↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 31,   GSK‐3β↓, 11,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 4,   Histones↑, 1,   HK2↓, 11,   HMG-CoA↓, 2,   lactateProd↓, 5,   LDHA↓, 4,   LDL↓, 3,   LDL↑, 1,   lipoGen↓, 1,   NADPH↓, 4,   NADPH↑, 2,   NPC1L1↓, 2,   O-Glc↓, 1,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 8,   p‑PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PDKs↓, 1,   PFK↓, 2,   PFK1↓, 1,   PFK2?, 1,   PKM2↓, 9,   PKM2↑, 1,   PKM2:PKM1↓, 1,   SIRT1↓, 8,   SIRT1↑, 9,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 2,   Warburg↓, 6,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 6,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 6,   Apoptosis↑, 180,   mt-Apoptosis↑, 3,   ASK1↑, 1,   BAD↓, 2,   BAD↑, 4,   Bak↑, 12,   BAX↓, 3,   BAX↑, 72,   BAX⇅, 1,   Bax:Bcl2↑, 22,   Bcl-2↓, 78,   Bcl-2↑, 2,   Bcl-xL↓, 27,   BID↓, 1,   BID↑, 3,   BIM↓, 1,   BIM↑, 5,   BNIP3↝, 1,   BOK↑, 1,   Casp↓, 2,   Casp↑, 34,   Casp↝, 1,   cl‑Casp↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3?, 1,   Casp3↓, 4,   Casp3↑, 95,   cl‑Casp3↑, 12,   proCasp3↑, 2,   Casp6↓, 1,   Casp6↑, 1,   Casp7↑, 15,   Casp8↓, 1,   Casp8↑, 23,   Casp8∅, 1,   cl‑Casp8↑, 3,   proCasp8↑, 1,   pro‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 62,   cl‑Casp9↑, 7,   cFLIP↓, 2,   Cupro↑, 2,   Cyt‑c↑, 66,   Cyt‑c↝, 2,   Diablo↑, 8,   DR5↑, 22,   FADD↑, 7,   Fas↓, 2,   Fas↑, 18,   FasL↑, 7,   Ferroptosis↑, 12,   GSDME↑, 1,   IAP1↓, 8,   IAP2/BIRC3↓, 5,   ICAD↓, 1,   ICD↑, 1,   iNOS↓, 11,   Mcl-1?, 1,   Mcl-1↓, 29,   MDM2↓, 10,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↓, 1,   MOMP↑, 5,   NAIP↓, 1,   Necroptosis↑, 4,   necrosis↑, 3,   NOXA↑, 4,   p38↓, 1,   p38↑, 13,   p‑p38↓, 3,   p‑p38↑, 2,   Paraptosis↑, 2,   PUMA↑, 6,   Pyro↑, 3,   RIP1↑, 1,   RIP3↑, 1,   survivin↓, 54,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAIL⇅, 1,   TRAILR↑, 2,   TumCD↑, 16,   XIAP↓, 28,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 123,   Akt↑, 8,   Akt↝, 1,   Akt∅, 1,   p‑Akt↓, 27,   AKT1↓, 2,   Akt2↓, 1,   BRAF↓, 1,   CK2↓, 3,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 1,   CREB2↓, 1,   cSrc↓, 1,   DDIT4↑, 1,   DYRK1B↓, 1,   EGFR↓, 28,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 36,   ERK↑, 8,   ERK↝, 2,   ERK∅, 1,   p‑ERK↓, 9,   p‑ERK↑, 1,   FGFR1↓, 2,   FOXD3↑, 2,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   Hippo↓, 1,   Hippo↝, 1,   IGF-1R↓, 3,   IGFR↓, 1,   IKKα↓, 6,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 5,   JAK1↓, 3,   JAK1↑, 1,   JAK2↓, 10,   JNK↓, 3,   JNK↑, 13,   JNK↝, 1,   p‑JNK↓, 2,   LIMK1↓, 1,   MAPK↓, 33,   MAPK↑, 11,   MAPK↝, 1,   MEK↓, 5,   mTOR↓, 74,   mTOR↑, 1,   p‑mTOR↓, 3,   mTORC2↓, 2,   mTORC2↑, 1,   p70S6↓, 1,   p‑p70S6↓, 1,   P70S6K↓, 5,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 89,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 2,   PI3K/Akt↓, 1,   p‑PI3k/Akt/mTOR↓, 1,   PKCδ↓, 10,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 2,   PTEN↑, 24,   p‑PTEN↓, 1,   Raf↓, 3,   RAS↓, 10,   SHP1↑, 1,   Sp1/3/4↓, 16,   STAT↓, 3,   STAT3↓, 59,   STAT3↑, 2,   STAT3↝, 1,   p‑STAT3↓, 9,   p‑STAT3↑, 2,   STAT5↓, 1,   STAT6↓, 3,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 3,   ATF4↝, 1,   CBP↓, 2,   cJun↓, 3,   cJun↑, 2,   cMyc↓, 34,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 6,   DNMT3A↓, 2,   DNMT3B↓, 2,   DNMTs↓, 6,   EZH2↓, 1,   FOXM1↓, 4,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 5,   FOXO3↑, 6,   FOXO3↝, 1,   p‑FOXO3↓, 2,   H3↓, 2,   p‑H3↓, 1,   ac‑H3↑, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 23,   HDAC1↓, 7,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC4↓, 2,   HDAC8↓, 2,   HES1↓, 2,   miR-106b↓, 1,   miR-107↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-194↑, 1,   miR-200b↑, 1,   miR-203↑, 1,   miR-205↑, 1,   miR-21↓, 5,   miR-21↑, 1,   miR-218↑, 1,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 1,   miR-34a↑, 2,   miR-34b-5p↑, 1,   miR-375↑, 1,   miR-384↑, 1,   miR-422a↑, 1,   Myc↓, 5,   MYCN↓, 1,   NDRG1↑, 1,   NEAT1↓, 1,   OCT4↓, 8,   other?, 1,   other↓, 4,   other↑, 4,   other↝, 14,   SOX2↓, 3,   SOX4↓, 1,   SOX4↑, 1,   SOX9↓, 1,   SUV39H↓, 2,   TFE3↑, 1,   tumCV↓, 29,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 17,   COX17↝, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↑, 3,   ER Stress↓, 2,   ER Stress↑, 35,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 9,   HSP27↓, 2,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 16,   HSP90↑, 1,   HTRA↓, 2,   PERK↑, 6,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↑, 4,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 2,   ATG5↑, 4,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 9,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↓, 1,   LC3B-II↑, 3,   LC3II↑, 10,   LC3s↑, 1,   p62↓, 4,   p62↑, 3,   p‑p62↑, 1,   PARK2↑, 1,   RUBCN↓, 1,   SESN2↑, 2,   TumAuto↓, 1,   TumAuto↑, 44,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   BRCA1↓, 3,   BRCA1↑, 2,   BRCA1↝, 1,   BRCA2↓, 1,   DFF45↓, 1,   DFF45↑, 2,   DNAdam↓, 3,   DNAdam↑, 48,   DNArepair↓, 5,   DNArepair↑, 1,   m-FAM72A↓, 1,   G9a↓, 1,   hTERT/TERT↓, 11,   MGMT↓, 1,   p16↑, 2,   P53?, 1,   P53↑, 64,   P53↝, 3,   p‑P53↑, 2,   PARP↓, 1,   PARP↑, 15,   cl‑PARP↓, 2,   cl‑PARP↑, 52,   PARP1↑, 1,   PCNA↓, 20,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 15,   TOP1↓, 8,   TOP2↓, 6,   TOP2↑, 1,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 9,   CDK1↑, 2,   p‑CDK1↓, 2,   CDK2↓, 31,   CDK2↑, 2,   CDK4↓, 34,   CDK4↑, 2,   CDK4/6↓, 1,   CDK6↓, 17,   CDK6↑, 2,   CDK7↓, 1,   CDK8↓, 1,   CHK1↓, 1,   CHK1↑, 2,   Chk2↓, 1,   Chk2↑, 2,   Cyc↓, 3,   cycA1/CCNA1↓, 7,   CycB/CCNB1↓, 17,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 55,   CycD3↓, 3,   cycE/CCNE↓, 19,   cycE1↓, 1,   E2Fs↓, 5,   E2Fs↑, 1,   GADD45A↓, 1,   Ki-67↓, 21,   mitA↓, 1,   mitA↑, 1,   p19↑, 1,   P21?, 1,   P21↓, 2,   P21↑, 42,   p27/CDKN1B↑, 19,   pRB↑, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 5,   Securin↓, 1,   TubPol↓, 1,   TumCCA?, 1,   TumCCA↓, 7,   TumCCA↑, 156,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 3,   p‑4E-BP1↓, 1,   ALDH↓, 8,   Axin2↑, 1,   BMPs↑, 2,   CD133↓, 4,   CD133↑, 1,   CD24↓, 1,   CD34↓, 1,   cFos↓, 6,   cMYB↓, 2,   CSCs?, 1,   CSCs↓, 45,   CSCs↑, 2,   Diff↑, 4,   FGF↓, 2,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 5,   HH↓, 10,   HH∅, 1,   HMGCR↓, 1,   IGF-1↓, 10,   IGF-2↓, 1,   IGFBP3↑, 4,   Jun↓, 1,   Ki-67↓, 21,   Let-7↑, 2,   mTORC1↓, 5,   Nanog↓, 6,   Nestin↓, 1,   NICD↓, 1,   NOTCH↓, 11,   NOTCH1↓, 8,   NOTCH1↑, 3,   OGF↑, 1,   OGFr↑, 1,   p300↓, 2,   PTCH1↓, 1,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 3,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 87,   TumCG↑, 1,   TumCP↓, 145,   TumCP↑, 6,   tyrosinase↓, 1,   Wnt↓, 35,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   annexin II↓, 1,   AntiAg?, 1,   AP-1↓, 8,   ARG1/2↑, 1,   ASAP2↓, 1,   AXL↓, 1,   CA↓, 3,   Ca+2↓, 3,   Ca+2↑, 24,   Ca+2↝, 5,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↓, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   Chl↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   COL4A3↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 29,   EM↑, 1,   EMT↓, 64,   EMT↑, 2,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 18,   p‑FAK↓, 4,   p‑FAK↑, 1,   Fibronectin↓, 2,   GLI2↓, 1,   GLI3↓, 1,   IQGAP3↓, 1,   ITGB1↓, 2,   ITGB3↓, 3,   ITGB6↓, 1,   KRAS↓, 1,   LEF1↓, 1,   MALAT1↓, 2,   MET↓, 1,   MMP-10↓, 2,   MMP1↓, 9,   MMP13↓, 3,   MMP14↓, 1,   MMP16↓, 2,   MMP2?, 1,   MMP2↓, 73,   MMP3↓, 9,   MMP7↓, 9,   MMP9?, 1,   MMP9↓, 91,   MMP9↑, 2,   MMPs↓, 39,   MUC4↓, 2,   N-cadherin↓, 17,   NEDD9↓, 1,   p‑p44↓, 1,   PAK1↓, 1,   PAK1↑, 1,   pax↓, 1,   PDGF↓, 10,   Rac1↓, 3,   RECK↑, 3,   Rho↓, 5,   Rho↑, 1,   ROCK1↓, 4,   ROCK1↑, 1,   Slug↓, 9,   Smad1↓, 2,   Smad1↝, 1,   p‑SMAD2↓, 1,   SMAD3↓, 2,   p‑SMAD3↓, 1,   Snail?, 1,   Snail↓, 16,   STAC2↓, 1,   TET1↑, 2,   TGF-β↓, 17,   TGF-β↑, 1,   TGF-β↝, 1,   TGF-β1↓, 2,   TIMP1↑, 10,   TIMP2↓, 1,   TIMP2↑, 13,   TIMP3↑, 1,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 9,   TumCA↓, 1,   TumCI↓, 97,   TumCI↑, 1,   TumCMig↓, 76,   TumCMig↑, 3,   TumMeta?, 1,   TumMeta↓, 119,   TumMeta↑, 7,   Twist↓, 16,   TXNIP↑, 1,   uPA↓, 18,   uPAR↓, 2,   Vim↓, 24,   Zeb1↓, 7,   ZEB2↓, 2,   α-SMA↓, 2,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 39,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 420,   angioG↑, 10,   angioG∅, 1,   angioS↑, 1,   CD31/PECAM-1↓, 11,   EGR1↑, 1,   Endoglin↓, 1,   Endoglin↑, 1,   eNOS↓, 3,   HIF-1↓, 10,   Hif1a↓, 83,   Hif1a↑, 1,   Hif1a↝, 1,   LymphAG↓, 1,   NO↓, 3,   NO↑, 1,   TYMP/ECGF1↓, 1,   VCAM-1↓, 2,   VEGF↓, 173,   VEGF↑, 2,   VEGFR1↓, 4,   VEGFR2/KDR/Flk1↓, 31,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 8,   CLDN1↓, 2,   CLDN1↑, 1,   CLDN2↓, 1,   CTR1↝, 1,   CX43/GJA1↓, 1,   EPR↑, 10,   GLUT1↓, 12,   GLUT2↓, 1,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 78,   MMP↑, 2,   MMP↝, 1,   MPT↑, 5,   NHE1↓, 2,   OCLN↑, 1,   TJ↑, 1,   TRPV1↑, 2,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↓, 1,   CD44↓, 13,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 65,   COX2/PTGS2↑, 2,   CXCL16↓, 1,   CXCL6/GCP-2↓, 1,   CXCR2↓, 2,   CXCR4↓, 14,   DCells↑, 1,   DR4↑, 9,   Gal-3↓, 2,   GM-CSF↓, 3,   HLA-I/II↑, 1,   ICAM-1↓, 7,   IFN-γ↓, 2,   IFN-γ↑, 3,   Igs↑, 1,   IL1↓, 6,   IL10↓, 4,   IL10↑, 2,   IL12↓, 1,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 15,   IL2↓, 2,   IL2↑, 5,   IL4↓, 2,   IL4↑, 1,   IL6↓, 32,   IL8↓, 9,   Imm↑, 21,   Imm↝, 6,   INF-γ↑, 1,   Inflam↓, 44,   Inflam↝, 1,   LIF↑, 1,   LRIG1↑, 1,   M2 MC↓, 2,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 6,   MCT1↓, 1,   MDSCs↓, 2,   MIP2↓, 1,   mPGES-1↓, 2,   MyD88↓, 1,   MyD88↑, 1,   NAF1↓, 1,   NF-kB↓, 137,   NF-kB↑, 3,   NF-kB↝, 2,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 7,   NLRP3↓, 4,   NLRP3↑, 1,   p50↓, 1,   p65↓, 1,   PD-L1↓, 7,   PGE2↓, 16,   PSA↓, 6,   PSA∅, 1,   RAGE↓, 2,   SOCS-3↓, 1,   T-Cell↑, 1,   T-Cell↝, 1,   TCF↓, 3,   TCF↝, 1,   Th1 response↑, 1,   Th2↑, 1,   TLR4↓, 6,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 34,   TNF-α↑, 3,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRAF1↓, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,   pH↝, 1,   e-pH↑, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AR↓, 12,   CYP17A1↓, 1,   CYP19↓, 2,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   Estro↝, 1,   FGF21↓, 2,   GR↑, 1,   PPARα↓, 2,   cl‑PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   BioAv↓, 50,   BioAv↑, 58,   BioAv↝, 8,   BioEnh↑, 5,   CBR1↓, 1,   chemoR↓, 1,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 159,   ChemoSen⇅, 1,   ChemoSen∅, 1,   CompStab?, 1,   CompStab↓, 3,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 3,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 3,   DDS↑, 5,   Dose?, 4,   Dose↓, 4,   Dose↑, 3,   Dose⇅, 1,   Dose↝, 53,   Dose∅, 8,   DrugR↓, 2,   eff?, 1,   eff↓, 30,   eff↑, 98,   eff↝, 10,   eff∅, 3,   GSTZ1↓, 1,   Half-Life↓, 16,   Half-Life↑, 5,   Half-Life↝, 9,   Half-Life∅, 2,   MDR1↓, 11,   MRP1/ABCC1↓, 3,   NAT↓, 1,   P-gp/ABCB1↓, 20,   P-gp/ABCB1↝, 1,   P450↓, 4,   RadioS?, 2,   RadioS↑, 49,   selectivity?, 1,   selectivity↑, 65,   Synergy↑, 100,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   AFP↑, 1,   ALAT↓, 3,   ALP↓, 3,   AR↓, 12,   ascitic↓, 2,   AST↓, 2,   BRAF↓, 1,   BRCA1↓, 3,   BRCA1↑, 2,   BRCA1↝, 1,   CEC↝, 1,   CIT↓, 1,   CRP↓, 2,   CTC↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 28,   EGFR↝, 1,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 1,   Ferritin↓, 2,   FOXM1↓, 4,   HemoG↓, 1,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 11,   IL6↓, 32,   KRAS↓, 1,   LDH↓, 6,   LDH↑, 2,   Maspin↑, 1,   Myc↓, 5,   NOS2↓, 1,   PD-L1↓, 7,   PSA↓, 6,   PSA∅, 1,   RAGE↓, 2,   TP53↑, 3,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 60,   AntiCan∅, 1,   antiNeop↑, 3,   AntiTum↑, 23,   cardioP↑, 10,   CardioT↓, 1,   CardioT↑, 2,   chemoP↑, 29,   chemoPv↑, 25,   ChemoSideEff↓, 5,   fatigue↓, 3,   fatigue∅, 1,   hepatoP↓, 1,   hepatoP↑, 9,   Mucositis↓, 1,   neuroP↑, 8,   OS↑, 19,   OS∅, 1,   Pain↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 8,   QoL∅, 1,   radioP↑, 10,   Remission↑, 3,   RenoP↑, 7,   Risk↓, 19,   Risk↑, 2,   Sleep↑, 1,   toxicity↓, 27,   toxicity↑, 4,   toxicity↝, 11,   toxicity∅, 1,   TumNum?, 1,   TumVol↓, 26,   TumVol∅, 1,   TumW↓, 15,   TumW∅, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 1,   GutMicro↑, 6,   GutMicro↝, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 996

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 6,   antiOx↑, 75,   Catalase↑, 25,   DPPH↓, 1,   GPx↑, 20,   GPx1↑, 3,   GPx4↑, 2,   GSH↑, 20,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 9,   H2O2↓, 2,   HDL↑, 1,   HNE↓, 1,   HO-1↑, 11,   i-Iron↓, 1,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↓, 23,   MDA↓, 13,   MPO↓, 1,   NADH↓, 1,   NOX4↓, 1,   Nrf1↑, 2,   NRF2↑, 24,   RNS↓, 1,   ROS↓, 79,   ROS↑, 2,   ROS∅, 1,   SAM-e↑, 1,   selenoP↑, 1,   SOD↑, 27,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 3,   TBARS↓, 1,   TOS↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   OXPHOS↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 4,   5LO↝, 1,   ALAT?, 1,   ALAT↓, 5,   AMPK↓, 1,   AMPK↑, 3,   ATP↑, 1,   ATP↝, 1,   BHB↑, 1,   cytoP450↓, 1,   glucose↓, 5,   GlucoseCon↑, 1,   Glycolysis↑, 1,   GSK‐3β↓, 2,   HK2↑, 1,   LDHA↑, 1,   LDL↓, 5,   lipidLev↓, 1,   NAD↝, 1,   NADPH↑, 1,   PFKL↑, 1,   PFKM↑, 1,   PFKP↑, 1,   PKM2↑, 1,   SIRT1↑, 7,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   ASC?, 1,   BAX↓, 2,   Bcl-2↑, 1,   Casp1↓, 1,   Casp3↓, 5,   Casp9↓, 3,   Cyt‑c↓, 2,   Ferroptosis↓, 1,   iNOS↓, 10,   iNOS↑, 1,   p38↓, 3,   Pyro?, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 1,   AKT1↑, 1,   p‑CREB↑, 1,   ERK↓, 1,   ERK↑, 2,   JAK2↓, 1,   JNK↓, 1,   JNK↑, 1,   p‑JNK↓, 2,   p‑LIMK1↑, 1,   MAPK↓, 4,   MAPK↑, 2,   p‑MEK↑, 1,   mTOR↓, 1,   mTOR↑, 1,   PDGFR-BB↑, 1,   PI3K↓, 1,   PI3K↑, 2,   PKCδ↑, 1,   Sp1/3/4↓, 1,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF4↓, 1,   cMyc↓, 2,   HDAC↓, 1,   OCT4↓, 1,   other↓, 4,   other↑, 5,   other↝, 6,   SOX18↑, 1,   SOX9↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 1,   ER Stress↓, 3,   GRP78/BiP↓, 1,   HSP70/HSPA5↑, 2,   HSPs↑, 1,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   GADD45A↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CD133↑, 1,   Diff↑, 1,   FGF↑, 2,   IGF-1↑, 1,   MSCs↑, 1,   neuroG↑, 2,   TumCP↓, 4,   tyrosinase↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   Ca+2↓, 2,   Ca+2↑, 1,   Ca+2↝, 2,   p‑Cofilin↑, 1,   COL1↑, 1,   COL2A1↑, 1,   EMT↓, 1,   FAK↑, 1,   ITGB1↑, 1,   p‑MLC2/MYL9↑, 1,   MMP13↓, 1,   MMP2↓, 2,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 2,   MMP9↑, 2,   MYPT1 / PPP1R12A↑, 1,   p‑MYPT1 / PPP1R12A↑, 1,   N-cadherin↑, 1,   Rac1↑, 1,   Rho↓, 1,   ROCK1↑, 1,   serineP↓, 1,   Snail↑, 1,   TGF-β↓, 1,   TGF-β↑, 3,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP2↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   Twist↑, 1,   uPA↓, 1,   Vim↑, 1,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 14,   angioG↑, 28,   angioG↝, 1,   CD31/PECAM-1↑, 1,   E-sel↓, 1,   eNOS↓, 2,   eNOS↑, 2,   Hif1a↓, 2,   Hif1a↑, 4,   NO↓, 8,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 8,   VEGF↑, 12,   VEGFR2/KDR/Flk1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 6,   CLDN5↑, 1,   GastroP↑, 1,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   ketosis↑, 1,   MMP↑, 4,   MMP↝, 1,   MMP∅, 1,   OATPs↓, 1,   VGCC↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 23,   CXCR4↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 2,   IL1↓, 1,   IL10↓, 2,   IL10↑, 3,   IL12↓, 1,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 12,   IL2↓, 1,   IL4↓, 1,   IL6↓, 16,   IL6↑, 1,   IL8↓, 1,   Imm↑, 6,   Imm⇅, 1,   Imm↝, 1,   Inflam↓, 87,   Inflam↑, 3,   IRF3↓, 2,   MCP1/CCL2↓, 1,   MyD88↓, 2,   NF-kB↓, 22,   NK cell↑, 1,   NLRP3↓, 3,   p65↓, 1,   PGE2↓, 9,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 3,   TLR4↓, 3,   TLR4∅, 1,   TNF-α↓, 20,   TNF-α↑, 1,   TRIF↓, 1,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 7,   BChE↓, 1,   BDNF↑, 1,   GABA↑, 2,   GABA↝, 1,   MAOA↓, 1,   MAOB↓, 2,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 9,   BACE/β-secretase↓, 1,   tau↓, 3,   p‑tau↓, 3,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↓, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 27,   BioAv↑, 29,   BioAv⇅, 1,   BioAv↝, 14,   BioAv∅, 1,   BioEnh↑, 2,   CompStab↑, 2,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 8,   Dose∅, 1,   eff↑, 8,   eff↝, 2,   GSTA1↑, 2,   Half-Life↑, 2,   Half-Life↝, 5,   Half-Life∅, 3,   P450↓, 1,   selectivity↑, 1,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 5,   ALP↓, 2,   ascitic↓, 1,   AST↓, 7,   BloodF↑, 1,   BMD↑, 3,   BP↓, 2,   Calcium↑, 1,   CRP↓, 4,   hs-CRP↓, 1,   IL6↓, 16,   IL6↑, 1,   LDH↓, 4,   Mag↑, 1,   NOS2↓, 1,   TC↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 6,   AntiArt↑, 3,   AntiCan↓, 2,   AntiCan↑, 10,   AntiDiabetic↓, 1,   AntiDiabetic↑, 17,   AntiTum↓, 1,   AntiTum↑, 2,   Bone Healing↑, 1,   cardioP↑, 30,   cardioP⇅, 1,   chemoP↑, 3,   chemoPv↑, 3,   ChemoSideEff↓, 2,   cognitive↓, 1,   cognitive↑, 8,   diuretic↑, 1,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 25,   memory↑, 11,   Mood↑, 1,   motorD↑, 2,   neuroP?, 1,   neuroP↓, 2,   neuroP↑, 43,   Obesity↓, 5,   OS↑, 1,   Pain↓, 3,   PDE4↓, 1,   radioP↑, 3,   RenoP↑, 5,   Risk↓, 2,   Sleep↑, 1,   Stress↓, 1,   Stroke↓, 3,   Stroke↝, 1,   toxicity↓, 31,   toxicity↑, 3,   toxicity↝, 7,   toxicity∅, 8,   Weight↓, 1,   Wound Healing↑, 5,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 8,   AntiFungal↑, 4,   AntiP↑, 4,   AntiViral↑, 8,   Bacteria↓, 17,   Bacteria↑, 1,   GutMicro↑, 11,   GutMicro↝, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,  
Total Targets: 360

Scientific Paper Hit Count for: angioG, angiogenesis
14 Magnetic Fields
14 Thymoquinone
12 itraconazole
11 Curcumin
11 Chrysin
9 Fisetin
9 Fucoidan
9 MCT, metronomic chemo
9 Resveratrol
9 Sulforaphane (mainly Broccoli)
9 Silymarin (Milk Thistle) silibinin
8 Artemisinin
8 Propolis -bee glue
8 Copper and Cu NanoParticles
8 Kaempferol
8 Quercetin
8 Luteolin
7 Ashwagandha(Withaferin A)
7 Betulinic acid
7 Cinnamon
7 Radiotherapy/Radiation
7 Eugenol
7 Nimbolide
6 Capsaicin
5 Silver-NanoParticles
5 Apigenin (mainly Parsley)
5 Berberine
5 chitosan
5 Ellagic acid
5 EGCG (Epigallocatechin Gallate)
5 Formononetin
5 Gambogic Acid
5 Magnolol
5 Melatonin
5 Selenite (Sodium)
4 immunotherapy
4 Beta-Caryophyllene
4 Boswellia (frankincense)
4 Rosmarinic acid
4 Celastrol
4 D-limonene
4 Disulfiram
4 Isoliquiritigenin
4 Lycopene
4 Phenethyl isothiocyanate
3 Carvacrol
3 Chlorogenic acid
3 Hydroxycinnamic-acid
3 Coenzyme Q10
3 Crocetin
3 Dichloroacetate
3 Emodin
3 Ferulic acid
3 Gallic acid
3 phytic acid, Inositol hexakisphosphate
3 Ivermectin
3 Juglone
3 mebendazole
3 methylseleninic acid
3 Piperlongumine
3 tetrathiomolybdate
2 3-bromopyruvate
2 chemodynamic therapy
2 Allicin (mainly Garlic)
2 Alpha-Lipoic-Acid
2 Chemotherapy
2 beta-glucans
2 Baicalein
2 Boron
2 Caffeic acid
2 Carnosic acid
2 chaetocin
2 Carica papaya leaf extract
2 Cucurbitacin
2 Deguelin
2 Diclofenac
2 Dipyridamole
2 Dandelion Root
2 Ginkgo biloba-EGb 761
2 Flaxseed/Linseed
2 Garcinol
2 Ginkgolide B
2 Helleborus niger extracts – Christmas Rose
2 Honokiol
2 HydroxyTyrosol
2 isoflavones
2 Isovitexin
2 Licochalcone A
2 SDG/lignans
2 Linalool
2 Modified Citrus Pectin
2 Mistletoe/Viscum album Extracts
2 Naringin
2 Piperine
2 Pterostilbene
2 α-Santalol/Sandalwood oil
2 Selenium
2 Selenium NanoParticles
2 Ursolic acid
1 Annona atemoya Seed Extract
1 Auranofin
1 Astragalus
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Aspirin
1 Ascorbyl Palmitate
1 Atorvastatin
1 Aloe anthraquinones
1 Biochanin A
1 Bufalin/Huachansu
1 borneol
1 urea
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Sorafenib (brand name Nexavar)
1 Carnosine
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chocolate
1 Metformin
1 Citric Acid
1 Vitamin E
1 diet FMD Fasting Mimicking Diet
1 diet Ketogenic
1 Diindolylmethane
1 Zinc
1 Echinacea
1 Electrical Pulses
1 flavonoids
1 olaparib/LYNPARZA
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 Gossypol/AT-101
1 Hydrogen Gas
1 hydrogen sulfide
1 Hibiscus sabdariffa
1 Hops (Humulus lupulus)
1 isoorientin
1 Vitexin
1 low dose naltrexone
1 Docetaxel
1 Matrine
1 Sulindac
1 Paclitaxel/Taxol
1 Methyl Jasmonate
1 vp16, etoposide
1 Magnetic Field Rotating
1 Lemon Balm/Melissa officinalis
1 Neem
1 Oroxylin-A
1 Oleuropein
1 Oleocanthal
1 Marjoram (Origanum majorana)
1 Oregano
1 Phenylbutyrate
1 Plumbagin
1 Psoralidin
1 Ramucirumab (CYRAMZA)
1 Rutin
1 buckwheat sprouts
1 Salvia officinalis
1 salinomycin
1 Shikonin
1 Theobromine
1 Aflavin-3,3′-digallate
1 Thymol-Thymus vulgaris
1 Urolithin
1 Usnic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:447  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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