Cancer Database Query Results

Scientific Papers found: Click to Expand⟱

HCAs,

Natural Sources, Pharmacokinetics, Biological Activities and Health Benefits of Hydroxycinnamic Acids and Their Metabolites

Review,

Nor,

*Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *BioAv↓, *antiOx↑, *ROS↓, *Inflam↓, *neuroP↑, *cardioP↑, *hepatoP↑,

7506-

HCAs,

A Systematic Review and Comprehensive Evaluation of Human Intervention Studies to Unravel the Bioavailability of Hydroxycinnamic Acids

Review,

Nor,

*other↝, *BioAv↝, *Half-Life↝, *other↝, *Dose↝, *BioAv↝,

7509-

HCAs,

Oral Pharmacokinetics of Hydroxycinnamic Acids: An Updated Review

Review,

Nor,

*BioAv↓, *Dose↝, *BioAv↝, *BioAv↝, *BioAv↑,

2400-

HCAs,

The Mixture of Ferulic Acid and P-Coumaric Acid Suppresses Colorectal Cancer through lncRNA 495810/PKM2 Mediated Aerobic Glycolysis

in-vitro,

CRC,

in-vivo,

CRC,

mice

PKM2↓, Glycolysis↓, TumCG↓,

2407-

HCAs,

2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2

in-vitro,

Pca,

DU145

in-vitro,

Pca,

LNCaP

p‑PKM2↓, TumCG↓,

6869-

HCAs,

FA,

CA,

RosA,

Exploring the potential of cinnamic acid analogues in alzheimer's disease

Review,

AD,

*neuroP↑, *antiOx↓, *Inflam↓, *tau↓, *BioAv↓, *BBB↓, *BioAv↑,

7505-

HCQ,

GEM,

PacT,

A Randomized Phase II Preoperative Study of Autophagy Inhibition with High-Dose Hydroxychloroquine and Gemcitabine/Nab-Paclitaxel in Pancreatic Cancer Patients

Trial,

PC,

Thirty-four patients in the PGH arm and 30 in the PG arm

eff↑, TumAuto↓, Imm↑, CA19-9↓, OS↑,

1912-

HCQ,

TMZ,

Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy

in-vivo,

GBM,

U87MG

mice

LC3B-II↑, CHOP/DDIT3↑, cl‑PARP↑,

1441-

HCQ,

Chemo,

Case report: stage 4 pancreatic cancer to remission using paricalcitol and hydroxychloroquine in addition to traditional chemotherapy

Case Report,

GBM,

 hydroxychloroquine (600 mg BID)

TumAuto↓, Remission↑,

1439-

HCQ,

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine

in-vitro,

Melanoma,

 CQ (25, 50, 100 μM)

in-vitro,

CRC,

HCT116

TumAuto↓, eff↓, other↓,

1438-

HCQ,

Chemo,

Adding Chloroquine to Conventional Treatment for Glioblastoma Multiforme

Trial,

GBM,

Chloroquine tablets 150 mg, were commercially purchased
150 mg/d, starting on day 5 after surgery, and was continued for 12 months

30 patients

OS↑, *toxicity∅,

7169-

HDN-1,

CHA,

Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90

in-vitro,

Lung,

H1975

in-vitro,

Lung,

HCC827

in-vitro,

Lung,

A549

HSP90↓, TumCP↓, EGFR↓, STAT3↓, Akt↓, ERK↓, Raf↓, cycD1/CCND1↓, SUV39H↓,

1160-

HibSad,

Hibiscus sabdariffa anthocyanins are potential modulators of estrogen receptor alpha activity with favourable toxicology: a computational analysis using molecular docking, ADME/Tox prediction, 2D/3D QSAR and molecular dynamics simulation

Analysis,

NA,

ER(estro)↓,

7359-

HibSad,

Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed

Review,

Var,

AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,

7370-

HibSad,

Hibiscus sabdariffa leaf induces apoptosis of human prostate cancer cells in vitro and in vivo

vitro+vivo,

Pca,

LNCaP

n xenograft tumour studies.

in-vitro,

Pca,

PC3

in-vitro,

Pca,

DU145

eff↑, Dose↝, Bcl-2↓, Mcl-1↓, BAX↑, Cyt‑c↑, FasL↑, eff↑, TumW↓, TumVol↓, other↝,

7369-

HibSad,

Components in aqueous Hibiscus rosa-sinensis flower extract inhibit in vitro melanoma cell growth

in-vitro,

Melanoma,

B16-BL6

in-vitro,

Nor,

LA25

TumCG↓, selectivity↑, Dose↝, eff↑,

7367-

HibSad,

CUR,

Moringa,

CAP,

RosA

Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases

Review,

Nor,

*ACE/ACE1↓,

7366-

HibSad,

Does consumption of an aqueous extract of Hibscus sabdariffa affect renal function in subjects with mild to moderate hypertension?

Human,

Nor,

78 newly diagnosed but untreated subjects with mild to moderate hypertension attending the medical outpatients

*creat↓, *RenoP↑,

7365-

HibSad,

Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L

Review,

Var,

chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1/ATG6↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,

7364-

HibSad,

Hibiscus sabdariffa calyx extract induces anti-proliferative and anti-migratory effects in ovarian cancer

in-vitro,

Ovarian,

OVCAR-3

*Inflam↓, *AntiBio↑, *antiOx↑, TumCMig↓, AKT1↓, cycD1/CCND1↓,

7363-

HibSad,

Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation

Apoptosis↑, selectivity↑, p‑p38↑, JNK↑, cJun↑, Cyt‑c↑, Fas↑, FasL↑,

7362-

HibSad,

The effect of a water extract and anthocyanins of hibiscus sabdariffa L on paracetamol-induced hepatoxicity in rats

in-vivo,

Nor,

paracetamol-induced hepatoxicity in rat

*Dose↝, *hepatoP↑,

7361-

HibSad,

Hibiscus sabdariffa L. - a phytochemical and pharmacological review

Review,

Var,

*Bacteria↓, *hepatoP↑, *diuretic↑, *LDL↓, *antiOx↑, *ACE/ACE1↓, *Ca+2↝, *toxicity↓, *ROS↓, *RenoP↑,

7360-

HibSad,

Inhibition of angiotensin convertin enzyme (ACE) activity by the anthocyanins delphinidin- and cyanidin-3-O-sambubiosides from Hibiscus sabdariffa

Study,

Nor,

*diuretic↑, *BP↓, *ACE/ACE1↓,

7358-

HibSad,

Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne

Review,

Var,

chemoPv↑, *ROS↓, *other↝, *hepatoP↑, *lipid-P↓, Apoptosis↑, *LDL↓, RAS↓, Akt↓, NF-kB↓, Rho↝, MMPs↓, *AntiDiabetic↑, *Catalase↑, *GSH↑,

7357-

HibSad,

Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells

in-vitro,

CRC,

LoVo

0, 1, 2, and 3 mg/mL) were administered over 0, 12, 24, and 48 h

Apoptosis↑, AMPK↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑Casp3↑, Dose↝, mtDam↑, MMP↓, Akt↓,

7356-

HibSad,

Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics

in-vitro,

BC,

MCF7

in-vitro,

BC,

MDA-MB-231

AntiCan↑, Apoptosis↑, selectivity↑, ChemoSen↑, ROS↑, MMP↓, eff↑,

7355-

HibSad,

Evaluation of antitumoral effect of Hibiscus sabdariffa extract on human breast cancer cells

in-vitro,

BC,

MCF7

in-vitro,

BC,

MDA-MB-231

tumCV↓, ER-α36↓, BRCA1↓, Cav1↓, Proteasome↓, TumAuto↑, TumCMig↓, TumCI↓,

7354-

HibSad,

Hibiscus sabdariffa Leaf Extract Inhibits Human Prostate Cancer Cell Invasion via Down-Regulation of Akt/NF-kB/MMP-9 Pathway

vitro+vivo,

Pca,

LNCaP

MMP9↓, NF-kB↓, Akt↓, TumVol↓, PI3K↓, *antiOx↑, Dose↝,

7353-

HibSad,

Hibiscus sabdariffa Leaf Polyphenolic Extract Induces Human Melanoma Cell Death, Apoptosis, and Autophagy

in-vitro,

Melanoma,

A375

cl‑Casp↑, Bcl-2↓, Fas↑, FasL↑, ATG5↑, Beclin-1/ATG6↑, LC3B-II↑, TumAuto↑,

7352-

HibSad,

Efficacy and safety of Hibiscus sabdariffa in cardiometabolic health: An overview of reviews and updated dose-response meta-analysis

Review,

Nor,

*BP↓, *toxicity↓,

7351-

HibSad,

Induction of apoptosis by hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression

in-vitro,

AML,

HL-60

tumCV↓, DNAdam↑, RB1↓, Bcl-2↓, BAX↑,

7350-

HibSad,

Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway

in-vitro,

GC,

AGS

TumCD↑, DNAdam↑, P53↑, Bcl-2↓, Mcl-1↓, Cyt‑c↑, FasL↑, Fas↑, p38↑, BAX↑, Dose↝, TumCCA↑,

7349-

HibSad,

Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract

Trial,

Nor,

6 healthy volunteers.

*Dose↝, *Half-Life↓, *Half-Life↝, *BioAv↓, *antiOx↑, *BioAv↓,

7348-

Hne,

Apoptosis‐inducing activity of Helleborus nigerin ALL and AML

in-vitro,

AML,

TumCP↓, Casp3↑,

7347-

Hne,

Study of potent cytotoxic activity of Helleborus cyclophyllus Boiss against a human adenocarcinoma cell line

NA,

Lung,

A549

tumCV↓, selectivity↑, pro‑Casp3↓, cl‑PARP1↑,

7346-

Hne,

Subcutaneous application of Helleborus niger 12x in older patients with dementia-a retrospective cohort study

Trial,

AD,

*cognitive↑,

7345-

Hne,

A root extract of Helleborus niger possess cytotoxic properties in neuroblastoma cells

in-vitro,

neuroblastoma,

NXS2

TumCP↓, Casp8↑, Casp9↑, Ca+2↑,

7344-

Hne,

Cardiac Glycoside Compound Isolated from Helleborus thibetanus Franch Displays Potent Toxicity against HeLa Cervical Carcinoma Cells through ROS-Independent Autophagy

in-vitro,

Cerv,

HeLa

tumCV↓, ROS↑, eff↓, TumAuto↓,

7343-

Hne,

Comparative Evaluation of the Potential Antitumor of Helleborus purpurascens in Skin and Breast Cancer

in-vitro,

Melanoma,

A431

in-vitro,

BC,

MCF7

in-vitro,

BC,

MDA-MB-231

in-vitro,

Nor,

HaCaT

in-vitro,

Nor,

JB6

*Dose↝, *antiOx↑, selectivity↑, Bcl-2↓, BAD↑, BAX↑,

7341-

Hne,

Preclinical evaluation of safety and potential of black hellebore extracts for cancer treatment

Review,

Var,

angioG↓, TumCP↓, *Inflam↓, *Bacteria↓, *glucose↓, *neuroP↓, *hepatoP↓, *Imm↝,

7340-

Hne,

Differential cytotoxic properties of Helleborus niger L. on tumour and immunocompetent cells

in-vitro,

AML,

TumCP↓, Apoptosis↑, selectivity↑,

7339-

Hne,

Apoptosis-inducing activity of Helleborus niger in ALL and AML

in-vitro,

AML,

TumCP↓, DNAdam↓, Casp3↑, MMP↓, eff↑, Apoptosis↑,

7461-

HNK,

Honokiol: a potent chemotherapy candidate for human colorectal carcinoma

vitro+vivo,

CRC,

RKO

mice

Apoptosis↑, Casp↑, Dose↝, OS↑, *Inflam↓, *AntiThr↑, *antiOx↑, *Half-Life↝, TumCG↓,

7453-

HNK,

Determination of Potential Lead Compound from Magnolia officinalis for Alzheimer's Disease through Pharmacokinetic Prediction, Molecular Docking, Dynamic Simulation, and Experimental Validation

Study,

AD,

*BACE/β-secretase↓, *AChE↓, *QPCT/QC↓, *GSK‐3β↓, *toxicity↓,

7454-

HNK,

Updated progression of honokiol in lung cancer treatment

Review,

Lung,

AntiCan↑, eff↑,

7455-

HNK,

Honokiol in cancer: Roles in enhancing combination therapy efficacy and preventing post-transplant malignancies

Review,

Var,

ChemoSen↑, Imm↝, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiCan↑, *Inflam↓, *antiOx↑, Synergy↑, *TNF-α↓, *IL1?, *IL6?,

7456-

HNK,

Honokiol in the treatment of triple-negative breast cancer: a network pharmacology approach and experimental validation

vitro+vivo,

BC,

MDA-MB-231

 zebrafish xenograft model.

in-vitro,

BC,

MDA-MB-468

Apoptosis↑, TumCMig↓, TumCP↓, HSP90↓, AKT1↓, EGFR↓, HSP90↓, MDM2↓, HDAC1↓,

7457-

HNK,

Honokiol enhances the sensitivity of cetuximab in KRASG13D mutant colorectal cancer through destroying SNX3-retromer complex

in-vitro,

CRC,

ChemoSen↑,

7458-

HNK,

Honokiol induces ferroptosis in ovarian cancer cells through the regulation of YAP by OTUB2

in-vitro,

Ovarian,

OVCAR-3

TumCP↓, TumCI↓, Ferroptosis↑, YAP/TEAD↓, OTUB2↓,

Showing Research Papers: 4601 to 4650 of 8579
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8579

Pathway results for Effect on Cancer / Diseased Cells:

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1, Ingr?, 4, Ingr↑, 1, Ingr↝, 5,
Total Targets: 2886

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

NA↓, 1, NA↑, 1, NA↝, 2,

Redox & Oxidative Stress(tgid=1) ⓘ

3-NT↓, 1, 4-HNE↓, 6, antiOx?, 3, antiOx↓, 44, antiOx↑, 788, i-antiOx↑, 1, mt-antiOx↑, 1, ARE↑, 13, ARE↝, 1, Bil↓, 5, Bil↑, 2, Catalase↓, 9, Catalase↑, 254, Catalase↝, 2, Copper↓, 4, CoQ10↑, 1, DPPH↓, 2, DUOX1↓, 1, Fenton↓, 8, GCLC↑, 7, GCLC↝, 1, GCLM↑, 5, GCLM↝, 1, GPx↓, 6, GPx↑, 185, GPx↝, 1, GPx∅, 1, GPx1↑, 11, GPx3↑, 1, GPx4↓, 2, GPx4↑, 22, GPx4∅, 1, GSH↓, 17, GSH↑, 316, GSH⇅, 1, GSH∅, 2, GSH/GSSG↓, 1, GSH/GSSG↑, 3, GSR↓, 3, GSR↑, 38, GSS↑, 2, GSSG↓, 7, GSSG∅, 1, GSTs↓, 5, GSTs↑, 51, H2O2↓, 26, H2O2↑, 2, H2O2∅, 2, HDL↓, 3, HDL↑, 19, HDL∅, 3, HNE↓, 3, HNE↑, 1, HO-1?, 1, HO-1↓, 9, HO-1↑, 228, HO-1⇅, 1, HO-1↝, 1, HO-1∅, 1, HO-2↓, 1, hyperG↓, 2, Iron↓, 14, Iron↑, 2, Iron↝, 2, Iron∅, 1, i-Iron↓, 3, i-Iron↑, 1, Keap1↓, 22, Keap1↑, 2, Keap1↝, 2, ox-Keap1↑, 1, lipid-P?, 3, lipid-P↓, 247, lipid-P↑, 7, mt-lipid-P↓, 1, lipidDe↓, 1, MDA↓, 252, MDA↑, 12, MDA∅, 1, MPO↓, 29, MPO↑, 2, MPOD↑, 3, NADH↓, 1, NADPH/NADP+↑, 1, NFE2L2↓, 1, NOX↓, 6, NOX↑, 1, NOX1↓, 1, NOX2↓, 3, NOX4↓, 13, NQO1↑, 57, NQO1↝, 2, NQO1∅, 1, Nrf1?, 1, Nrf1↓, 1, Nrf1↑, 9, NRF2?, 1, NRF2↓, 18, NRF2↑, 407, NRF2⇅, 1, NRF2↝, 2, NRF2∅, 2, p‑NRF2↑, 2, ONOO↓, 1, PCO↓, 1, Prx↓, 1, Prx↑, 7, Prx4∅, 1, PrxII↑, 1, RNS↓, 11, ROMO1↑, 1, ROS?, 9, ROS↓, 1075, ROS↑, 58, ROS⇅, 13, ROS↝, 3, ROS∅, 26, i-ROS↑, 1, mt-ROS?, 1, mt-ROS↓, 10, mt-ROS↑, 4, RPM↑, 1, RPM↝, 1, SAM-e↓, 3, SAM-e↑, 1, selenoP↑, 20, SOD?, 2, SOD↓, 16, SOD↑, 367, SOD↝, 2, mt-SOD↑, 1, SOD1↓, 2, SOD1↑, 18, SOD2↓, 2, SOD2↑, 22, TAC↑, 48, TAC∅, 1, TBARS↓, 11, TBARS↑, 1, Thiols↓, 1, Thiols↑, 5, TOS↓, 3, TOS↑, 2, Trx↓, 2, Trx↑, 10, Trx1↑, 6, TrxR↓, 2, TrxR↑, 4, TrxR1↑, 4, UCPs↑, 2, UCPs↝, 1, uricA↓, 8, VitC↑, 16, VitE↓, 1, VitE↑, 8, xCT/SLC7A11↓, 2, xCT/SLC7A11↑, 5,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1, Ferritin↑, 2, FPN↑, 1, FTH1↓, 1, FTH1↑, 2, FTL↓, 1, IronCh↓, 1, IronCh↑, 55, IronCh↝, 1, Mets↝, 1, NCOA4↝, 1, TfR1/CD71↓, 5, TfR1/CD71↑, 1, Zn2+↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1, compI↓, 2, compI↑, 2, compII↑, 1, compIII↓, 1, compIII↑, 2, compV↑, 1, DRP1/DNM1L↓, 11, DRP1/DNM1L↑, 3, p‑DRP1/DNM1L↝, 1, EGF↑, 1, ETC↓, 4, ETC↑, 3, ETC↝, 2, FIS1↓, 12, FIS1↑, 3, HSP60/HSPD1↓, 1, Insulin↓, 9, Insulin↑, 9, Insulin↝, 1, MCU↓, 1, MFN1↓, 1, MFN1↑, 3, MFN1↝, 1, MFN2↓, 2, MFN2↑, 8, MFN2↝, 1, mitResp↓, 3, mitResp↑, 10, mtDam↓, 35, mtDam↑, 1, NGB↑, 1, OCR↓, 4, OCR↑, 7, mt-OCR↑, 1, OPA1↓, 2, OPA1↑, 4, OXPHOS↓, 3, OXPHOS↑, 9, PDH↑, 1, PGC-1α↓, 3, PGC-1α↑, 33, PGC-1α↝, 2, PINK1↓, 1, PINK1↑, 4, SIRT3↑, 16, TFAM↑, 2, UCP1↓, 1, VDAC1↓, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12-HETE↓, 1, 12LOX↓, 10, 12LOX↑, 1, 15-LOX/ALOX15↓, 1, 3MST/MPST↑, 1, 5-HETE↓, 1, 5LO↓, 29, 5LO↝, 1, ACADS/SCAD↑, 1, ACC↓, 3, ACC↑, 3, p‑ACC↑, 1, mt-ACC⇅, 1, Acetyl-CoA↓, 2, Acetyl-CoA↑, 5, ACLY↓, 2, ACLY∅, 1, AcOH↑, 2, ACSL4↓, 4, ACSL4∅, 1, adiP↓, 2, adiP↑, 8, e-ADO↑, 1, ALAT?, 1, ALAT↓, 96, ALAT↑, 3, ALAT∅, 4, ALDOA↑, 1, ALDOC↑, 1, AMP↓, 1, AMPK↓, 4, AMPK↑, 75, AMPK⇅, 1, AMPK↝, 1, p‑AMPK↑, 8, ATP↓, 6, ATP↑, 56, ATP↝, 1, ATP∅, 1, mt-ATP↑, 1, BMAL1↑, 1, Buty↑, 4, cAMP↑, 9, CBS↑, 1, Cit/L-Cit↝, 1, cPLA2↓, 1, CPT1A↑, 1, CRM↓, 1, CRM↑, 11, CYP51/14LDM↑, 1, cytoP450↓, 2, DGAT1↓, 1, DHA↑, 3, DHODH↓, 1, ECAR↓, 5, ECAR↑, 2, ECAR∅, 1, Eic↓, 1, FABP4↓, 2, FAM↑, 1, FAO↓, 2, FAO↑, 7, mt-FAO↑, 1, FASN↓, 9, FFA/NEFA↓, 2, FFA/NEFA↝, 1, G6PD↑, 3, GAPDH↑, 1, GDH↓, 1, glucoNG↓, 3, glucose↓, 32, glucose↑, 3, glucose↝, 6, glucose∅, 1, GlucoseCon↓, 4, GlucoseCon↑, 22, GlutMet↑, 1, glyC↓, 1, Glycolysis↓, 9, Glycolysis↑, 10, Glycolysis↝, 4, GPI↑, 1, GSK‐3β↓, 48, GSK‐3β↑, 9, GSK‐3β↝, 1, p‑GSK‐3β↓, 2, p‑GSK‐3β↑, 8, H2S↑, 4, ac‑Histones↑, 1, HK1↑, 1, HK2↓, 8, HK2↑, 6, HMG-CoA↓, 3, KeyT↑, 5, KeyT↝, 2, lactateProd↓, 7, LDHA↓, 4, LDHA↑, 5, LDHB↑, 1, LDL↓, 70, lipidLev↓, 5, lipoGen↓, 2, LTB4↓, 1, LTC4↓, 2, MATs↓, 1, NAD↓, 1, NAD↑, 8, NAD↝, 1, NADH:NAD↑, 1, NADPH↓, 20, NADPH↑, 17, NADPH∅, 1, NH3↓, 3, NH3↑, 1, ODC1↝, 1, PA↑, 2, PDK1 / PDPK1↓, 2, p‑PDK1 / PDPK1↓, 1, PDKs↓, 2, PDKs↑, 1, PFK↓, 3, PFK↑, 1, PFK1↓, 1, PFK2↓, 1, PFKL↑, 3, PFKM↑, 2, PFKP↓, 1, PFKP↑, 1, PGC1A↑, 2, PGM1?, 1, PIP3↑, 1, PKM1↑, 2, PKM2↓, 18, PKM2↑, 8, PLA2↓, 2, polyA↝, 1, PONs↓, 1, PONs↑, 1, PPP↓, 2, SCD1↓, 1, SCFAs↑, 4, SCFAs∅, 1, SIRT1↓, 4, SIRT1↑, 79, SIRT1↝, 1, SIRT1∅, 1, SIRT2↑, 3, SREBF2↓, 1, SREBP1/SREBF1↓, 8, SREBP1/SREBF1↑, 1, SREBP2↓, 1, SREBP2↑, 1, TCA↑, 1, Warburg↓, 1,

Cell Death(tgid=5) ⓘ

AIF↓, 4, AIF↑, 1, APAF1↓, 2, Apoptosis↓, 154, Apoptosis↑, 5, Apoptosis∅, 2, mt-Apoptosis↓, 1, ASC?, 1, ASC↓, 5, ASK1↓, 2, BAD↓, 3, BAX↓, 60, BAX↑, 8, Bax:Bcl2↓, 13, Bax:Bcl2↑, 3, Bax:Bcl2↝, 1, Bcl-2↓, 10, Bcl-2↑, 51, Bcl-2↝, 1, Bcl-2∅, 1, Bcl-xL↓, 1, Bcl-xL↑, 2, BNIP3↓, 1, Casp↓, 4, Casp1?, 1, Casp1↓, 14, cl‑Casp1↓, 2, proCasp1↓, 2, Casp12↓, 7, Casp3?, 1, Casp3↓, 93, Casp3↑, 10, Casp3∅, 2, cl‑Casp3↓, 17, cl‑Casp3↑, 1, proCasp3↓, 2, Casp6↓, 1, Casp7↓, 1, Casp8↓, 3, Casp8↑, 1, cl‑Casp8↑, 3, Casp9↓, 28, Casp9↑, 4, Casp9∅, 1, cl‑Casp9↓, 4, cl‑Casp9↑, 1, cellD↓, 1, Cyt‑c↓, 23, Cyt‑c↑, 5, Cyt‑c∅, 4, Fas↓, 6, Fas↑, 2, FasL↓, 1, Ferroptosis↓, 29, Ferroptosis↑, 4, GranB/GZMB↓, 1, GRP58↓, 1, GSDMD?, 1, GSDMD↓, 3, HEY1↑, 1, IAP1↓, 1, iNOS↓, 130, iNOS↑, 6, MLKL↓, 1, necrosis↓, 4, p38↓, 21, p38↑, 6, p‑p38↓, 12, Pyro?, 1, Pyro↓, 5, RIP1↓, 1, survivin↓, 1, TUNEL↓, 1, YAP/TEAD↑, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1, Akt↓, 28, Akt↑, 68, Akt↝, 3, p‑Akt↓, 10, p‑Akt↑, 18, e-Akt↑, 1, AKT1↓, 2, AKT1↑, 1, p‑AKT1↑, 1, AMPKα↑, 2, CaMKII ↓, 2, CK2↓, 1, CK2↑, 1, CREB↓, 3, CREB↑, 30, CREB∅, 1, p‑CREB↑, 13, DYRK1A↓, 2, EGFR↓, 3, ERK↓, 27, ERK↑, 30, p‑ERK↓, 11, p‑ERK↑, 11, e-ERK↑, 1, HCAR2↑, 1, HER2/EBBR2↓, 1, HGF/c-Met↑, 2, Hippo↑, 1, IGF-1R↓, 1, IGFR↓, 1, IKKα↓, 4, IKKα↑, 1, p‑IKKα↓, 4, IκB?, 1, IκB↓, 2, IκB↑, 3, p‑IκB↓, 1, JAK↓, 4, p‑JAK1↓, 1, JAK2↓, 4, JAK2↑, 4, p‑JAK2↓, 2, JNK↓, 30, JNK↑, 4, p‑JNK↓, 13, p‑JNK↑, 4, p‑LIMK1↑, 1, LPAR1/EDG2↑, 1, MAPK?, 1, MAPK↓, 66, MAPK↑, 13, MAPK↝, 4, p‑MAPK?, 1, p‑MAPK↓, 3, MEK↓, 1, p‑MEK↓, 1, p‑MEK↑, 1, p‑MKK4↑, 1, Mst1↓, 2, mTOR↓, 25, mTOR↑, 17, mTOR↝, 2, p‑mTOR↓, 8, p‑mTOR↑, 3, p‑p70S6↓, 1, P70S6K↓, 3, p‑P70S6K↓, 1, p‑P70S6K↑, 1, PDGFR-BB↓, 2, PDGFR-BB↑, 1, PDGFRB↓, 1, PFKFB2↓, 1, PI3K↓, 25, PI3K↑, 53, PI3K↝, 2, p‑PI3K↓, 3, p‑PI3K↑, 1, PKA↑, 7, PKCδ?, 1, PKCδ↓, 4, PKCδ↑, 8, p‑PKCδ↑, 1, PP2A↑, 9, PROKR1↑, 1, PROKR2↑, 1, PTEN↓, 8, PTEN↑, 6, p‑PTEN↓, 1, p‑PTEN↑, 1, PTP1B↓, 2, Raf↓, 1, RAS↓, 2, RKIP↑, 1, Sp1/3/4↓, 6, Sp1/3/4↑, 1, Src↓, 1, STAT↓, 5, STAT3?, 1, STAT3↓, 18, STAT3↑, 6, STAT3↝, 1, p‑STAT3↓, 4, p‑STAT3↑, 1, STAT4↓, 1, STAT5↓, 1, STAT6↓, 1, STEP↓, 1, STK11/LKB1↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1, AntiThr↑, 22, ATF2↑, 1, ATF4↓, 8, ATF4↑, 1, cJun↓, 5, p‑cJun↓, 5, cMyc↓, 2, cMyc↑, 1, p‑cMyc↑, 1, DNMT1↓, 6, DNMT3A↓, 3, DNMT3A↑, 1, DNMTs↓, 3, FOXO↑, 3, FOXO1↑, 2, FOXO1↝, 1, FOXO3?, 1, FOXO3↑, 7, H3↑, 1, ac‑H3↑, 1, H3K9↓, 1, H4↑, 1, ac‑H4↑, 1, HATs↓, 4, HDAC↓, 15, HDAC↑, 2, HDAC1↓, 2, HDAC2↓, 5, HDAC3↓, 4, HOTAIR↑, 1, KLF4↑, 1, MEF2D↑, 1, miR-107↑, 1, miR-155↓, 1, miR-22↑, 1, miR-23a-3p↓, 1, miR-29b↑, 1, miR-34a↓, 1, miR-34b-5p↓, 1, n-MYC↑, 1, OCT4↓, 1, other?, 24, other↓, 70, other↑, 131, other⇅, 2, other↝, 178, other∅, 6, PhotoS↑, 1, RUNX2↑, 2, RUNX2∅, 1, SOX18↑, 1, SOX2↑, 2, SOX9↑, 2, SUV39H↓, 1, TCF-4↓, 1, tumCV↓, 5, tumCV↑, 1, tumCV∅, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 5, ChemChap↓, 1, ChemChap↑, 2, CHOP/DDIT3↓, 21, CHOP/DDIT3↑, 2, eIF2α↓, 3, p‑eIF2α↓, 3, cl‑eIF2α↑, 1, ER Stress↓, 53, ER Stress↑, 2, GRP78/BiP↓, 28, GRP78/BiP↑, 4, GRP94↑, 1, HSF1↑, 2, HSP27↓, 1, HSP27↑, 1, HSP70/HSPA5↓, 1, HSP70/HSPA5↑, 18, HSP70/HSPA5↝, 1, HSP90↓, 2, HSP90↑, 3, HSPs↓, 1, HSPs↑, 6, HSPs↝, 1, IRE1↓, 7, NQO2↑, 1, PDI↓, 1, PERK↓, 8, p‑PERK↓, 2, p‑PERK↑, 1, UPR↓, 5, UPR↑, 3, XBP-1↓, 4,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1, ATG5↓, 1, ATG5↑, 2, ATG7↓, 1, autophagy↓, 2, autophagy↑, 1, autophagy↝, 1, Beclin-1/ATG6↓, 6, Beclin-1/ATG6↑, 11, CTSZ↓, 1, CTSZ↝, 1, LC3‑Ⅱ/LC3‑Ⅰ↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 3, LC3A↑, 1, LC3B↓, 1, LC3B↑, 3, LC3II↓, 2, LC3II↑, 5, LC3s↓, 1, lysosome↑, 1, MitoP↓, 1, MitoP↑, 7, p62↓, 9, p62↑, 7, PARK2↑, 7, TFEB↑, 1, ULK1/ATG1↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1, ATR↑, 1, DNAdam↓, 61, DNAdam↑, 3, DNAdam∅, 1, DNArepair↑, 6, importin α/β↓, 1, p16↓, 2, P53↓, 12, P53↑, 7, P53↝, 1, PARP↓, 3, PARP↑, 1, PARP∅, 1, p‑PARP↓, 1, cl‑PARP↓, 2, cl‑PARP↑, 2, PARP1↓, 1, cl‑PARP1↓, 1, PCNA↓, 4, PCNA↑, 1, RAD51↓, 1, SIRT6↑, 3, Telomerase↓, 1, TOP2↑, 1, TP53↑, 1, γH2AX↓, 1, p‑γH2AX↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1, CDK2↓, 2, CDK4↓, 1, CDK5↓, 9, cellSen↓, 1, cellSen↑, 1, cycA1/CCNA1↓, 1, CycB/CCNB1↓, 1, cycD1/CCND1↓, 4, cycE/CCNE↓, 1, cycE/CCNE↑, 1, E2Fs↑, 2, GADD34↓, 1, GADD45A↑, 1, Ki-67↓, 4, Ki-67↑, 2, P21↓, 6, P21↑, 6, RB1↓, 1, TumCCA↑, 8,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↑, 1, BMP2↑, 3, BMPs↓, 1, BMPs↑, 2, CD133↑, 1, CD34↑, 1, CEBPA↓, 2, cFos↓, 1, cFos↑, 1, CHIP↑, 1, Choline↑, 3, CLOCK↝, 2, Diff↓, 2, Diff↑, 14, Diff↝, 2, EP2↓, 1, EP2↑, 1, EP300↓, 2, FGF↑, 7, GH↑, 3, Gli1↑, 1, HH↓, 2, HMGCR↓, 2, IGF-1↓, 9, IGF-1↑, 16, IGFBP1↑, 1, IGFBP3↓, 1, IGFBP3↑, 1, Jun↓, 1, Jun↑, 1, Ki-67↓, 4, Ki-67↑, 2, MSCs↑, 1, mTORC1↓, 3, Nestin↑, 1, neuroG↑, 17, NOTCH↓, 1, NOTCH↑, 1, NOTCH1↑, 2, p300↓, 1, Shh↓, 1, Shh↑, 1, STAT1↓, 1, p‑STAT1↓, 1, TumCG↓, 4, TumCG↑, 1, TumCG∅, 1, TumCP↓, 9, TumCP↑, 1, tyrosinase↓, 2, Wnt↓, 3, Wnt↑, 4, Wnt/(β-catenin)↓, 1, Zn2+↓, 1,

Migration(tgid=13) ⓘ

ACTA2↓, 1, AntiAg↓, 3, AntiAg↑, 97, AntiAg∅, 3, AP-1↓, 18, AP-1↑, 1, ARG1/2↑, 2, mt-ATPase↑, 1, BACH1↓, 1, Ca+2?, 3, Ca+2↓, 47, Ca+2↑, 20, Ca+2↝, 14, Ca+2∅, 1, p‑Ca+2↓, 1, i-Ca+2↓, 2, mt-Ca+2↓, 1, cal2↓, 5, Cartilage↑, 11, p‑Cofilin↓, 1, p‑Cofilin↑, 1, COL1↓, 6, COL1↑, 2, COL1∅, 1, COL1A1↓, 1, COL2A1↑, 2, COL3A1↓, 3, E-cadherin↓, 1, E-cadherin↑, 7, EMT↓, 7, EMT↑, 2, F-actin↓, 1, F-actin↑, 1, FAK↑, 2, Fibronectin↓, 2, Fibrosis↓, 1, FLRT2↑, 1, FNDC5↑, 1, GIT1↑, 1, heparanase↑, 1, ITGA5↓, 1, ITGB1↓, 1, ITGB1↑, 1, LAMs↑, 1, LRP1↑, 3, p‑MLC2/MYL9↑, 1, MMP-10↓, 1, MMP-10↝, 1, MMP1↓, 5, MMP11↑, 1, MMP13↓, 8, MMP2↓, 14, MMP2↑, 6, MMP3↓, 5, MMP3↑, 2, MMP7↓, 1, MMP9↓, 32, MMP9↑, 6, MMPs↓, 9, MMPs↑, 3, MUC1↑, 3, MYPT1 / PPP1R12A↑, 1, p‑MYPT1 / PPP1R12A↑, 1, N-cadherin↓, 1, N-cadherin↑, 2, Na+↑, 2, Na+↝, 1, Netrins↑, 1, NFAM1↑, 1, NFAT↓, 1, NFAT↑, 2, OPN↑, 1, PAI-1/SERPINE1↓, 1, PDGF↓, 1, PDGF↑, 1, PROK2↑, 1, proline↝, 1, Rac1↑, 1, p‑Rac1↓, 1, Rho↓, 7, ROCK1↓, 7, ROCK1↑, 1, Sema3A/PlexinA1↑, 1, serineP↓, 1, SLIT2↑, 1, Smad1↑, 1, p‑Smad1↑, 1, SMAD2↓, 1, p‑SMAD2↓, 3, SMAD3↓, 3, p‑SMAD3↓, 1, p‑SMAD3↑, 1, SMAD4↑, 1, SMAD5↑, 1, p‑SMAD5↑, 1, Smad7↑, 2, Snail↓, 1, Snail↑, 1, SPARC↓, 1, STAC2↑, 1, p‑T-cadherin↓, 2, TG2/TGase↓, 4, TGF-β↓, 21, TGF-β↑, 12, TGF-β1↓, 6, TGF-β1↑, 4, TIMP1↓, 5, TIMP1↑, 3, TIMP2↑, 3, TregCell↑, 1, TumCI↓, 2, TumCI∅, 1, TumCMig↓, 3, TumCMig↑, 1, TumCMig∅, 1, TumMeta↓, 2, Twist↑, 1, TXNIP↓, 8, TXNIP↑, 2, Tyro3↓, 1, uPA↓, 1, Vim↓, 9, Vim↑, 1, Zeb1↓, 1, α-SMA↓, 19, α-SMA↑, 1, α-SMA↝, 1, α-tubulin↓, 2, β-catenin/ZEB1↓, 4, β-catenin/ZEB1↑, 8, β-catenin/ZEB1↝, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG?, 1, angioG↓, 14, angioG↑, 26, angioG↝, 1, CD31/PECAM-1↓, 2, CD31/PECAM-1↑, 3, E-sel↓, 6, ECM/TCF↑, 1, EGR4↑, 1, Endoglin↑, 1, eNOS↓, 2, eNOS↑, 7, p‑eNOS↑, 2, HIF-1↓, 1, Hif1a↓, 19, Hif1a↑, 14, Hif1a↝, 1, Hif1a∅, 2, HIF2a↑, 1, Hypoxia↓, 1, LOX1↓, 2, NO?, 1, NO↓, 110, NO↑, 17, NPY↑, 1, P-sel↓, 1, REL↑, 1, TXA2↓, 8, VCAM-1↓, 19, VEGF↓, 22, VEGF↑, 31, VEGFR2/KDR/Flk1↓, 1, VEGFR2/KDR/Flk1↑, 1, p‑VEGFR2/KDR/Flk1↓, 1,

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 3, AQPs↑, 3, pol-AQPs↑, 1, BBB?, 3, BBB↓, 9, BBB↑, 161, BBB↝, 14, BBB∅, 4, CellMemb↑, 6, CLDN1↓, 2, CLDN1↑, 2, CLDN1↝, 1, CLDN3↑, 1, CLDN4↑, 1, CLDN5↓, 1, CLDN5↑, 1, EPR↑, 3, GastroP↑, 15, GLUT1↓, 2, GLUT1↑, 5, GLUT2↑, 2, GLUT3↑, 5, GLUT4↓, 1, GLUT4↑, 10, GlyFlow↑, 3, H+/K+-ATPase↓, 1, IBI↑, 12, LAT↑, 1, MMP↓, 16, MMP↑, 77, MMP⇅, 1, MMP↝, 1, MMP∅, 4, MPT↑, 1, MUC19↓, 1, MUC2↓, 1, MUC5AC↓, 2, Na+↑, 2, Na+↝, 1, NHE3↑, 1, OATPs↓, 3, OCLN↓, 3, OCLN↑, 6, SVCT-2↑, 1, TJ↓, 1, TJ↑, 5, TJ↝, 1, TRPA1↑, 2, TRPC1↓, 1, TRPC1↑, 1, TRPM7↓, 4, TRPM7⇅, 1, TRPM7↝, 1, TRPV1↑, 8, TRPV3↑, 2, VGCC↓, 1, VGCC↑, 2, VGCC⇅, 1, VGCC↝, 1, VGSC↓, 1, VGSC↑, 1, Vm/CMP↑, 2, ZO-1↓, 5, ZO-1↑, 12, ZO-1↝, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 3, AIM2↓, 2, BALF-Infl↓, 3, BALF-Lym↓, 1, CB2 / CNR2↑, 5, CCL11↓, 2, CD14↑, 1, CD19↑, 1, CD25+↓, 1, CD25+↑, 1, CD4+↑, 8, CD69↓, 1, CD8+↑, 4, cGAS–STING↓, 2, COX1↓, 24, COX1↑, 1, COX2/PTGS2?, 1, COX2/PTGS2↓, 206, COX2/PTGS2↑, 2, COX2/PTGS2∅, 1, CTLA-4↓, 1, CXCc↓, 2, CXCc↑, 1, CXCL1↓, 1, CXCL12↑, 1, CXCL15↓, 1, CXCR2↑, 1, CXCR4↓, 2, DCells↑, 1, Dectin1↑, 1, DR4↓, 1, Eos↓, 8, p‑FcεRI↓, 1, FOXP3↑, 2, GM-CSF↓, 1, GM-CSF↑, 1, HCAR2↑, 1, HMGB1↓, 11, ICAM-1↓, 23, IFN-γ↓, 26, IFN-γ↑, 10, IFN-γ∅, 1, IgE↓, 7, IgG1↓, 1, IL1?, 1, IL1↓, 18, IL1↑, 1, IL10?, 1, IL10↓, 21, IL10↑, 44, IL10∅, 1, IL12↓, 10, IL12↑, 1, IL13↓, 7, IL17↓, 20, IL17↑, 2, IL17∅, 1, IL18↓, 11, IL18↑, 1, IL1RL1/ST2↓, 1, IL1α↓, 2, IL1α∅, 1, IL1β↓, 234, IL1β↑, 2, IL1β∅, 1, IL2↓, 17, IL2↑, 6, IL22↓, 3, IL23↓, 4, IL33↓, 3, IL4↓, 23, IL4↑, 10, IL4∅, 1, IL5↓, 11, IL5↑, 1, IL6?, 3, IL6↓, 258, IL6↑, 11, IL8↓, 45, IL8↑, 1, IL8∅, 1, ILC2↓, 1, Imm↓, 2, Imm↑, 73, Imm⇅, 2, Imm↝, 2, INF-γ↓, 3, Inflam?, 7, Inflam↓, 1000, Inflam↑, 15, Inflam∅, 2, IP-10/CXCL-10↓, 1, IP-10/CXCL-10↑, 1, IRF3↓, 4, LIF↑, 1, LPS↓, 3, LTA/TNF-β↓, 1, LTA/TNF-β↑, 1, M1↓, 1, M2 MC↑, 2, pol-M2 MC↑, 2, Macrophages↓, 1, MCP1/CCL2↓, 26, MCP1/CCL2↑, 2, MCP1/CCL2↝, 1, MCP1/CCL2∅, 1, MCT1↓, 1, MIP‑1α/CCL3↓, 5, MIP2↓, 3, mPGES-1↓, 1, MyD88↓, 10, NeuroI↓, 15, Neut↓, 3, Neut↑, 2, NF-kB?, 1, NF-kB↓, 356, NF-kB↑, 9, p‑NF-kB↓, 9, NK cell↑, 10, NLRP3↓, 91, NLRP3↑, 3, NOD1↓, 1, OSM↑, 1, p‑p50↓, 1, p65↓, 9, p‑p65↓, 3, PAF↓, 2, PAF↑, 2, PAR-2↓, 1, PGD2↓, 1, PGE1↓, 1, PGE2↓, 76, PGE2↑, 3, PSA↓, 2, PSA∅, 1, RAGE↓, 8, RANTES↓, 5, SOCS-3↓, 1, T-Cell↑, 1, Th1 response↓, 2, Th1 response↑, 1, Th17↓, 1, Th2↓, 3, Th2↑, 2, TLR1↓, 3, TLR2↓, 10, TLR3↓, 1, TLR4↓, 43, TLR4↑, 1, TLR4∅, 1, TNF-α?, 1, TNF-α↓, 370, TNF-α↑, 12, TRAF1↓, 1, TRAF6↓, 1, Treg lymp↓, 1, Treg lymp↑, 1, Treg lymp↝, 1, TREM-1↓, 1, TRIF↓, 3, VitD↑, 6, β-HEX↓, 2,

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↑, 2, Astr↓, 2, GFAP↓, 6, MGlio↓, 1, pH↓, 1, pH↑, 1, pH↝, 2, Temp↝, 1, TREM2↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 4, 5HT↑, 34, Ach?, 1, Ach↑, 48, AChE↓, 200, AChE↑, 3, AChE↝, 2, AChE∅, 5, ADAM10↑, 16, ADAM10↝, 2, BChE?, 1, BChE↓, 36, BChE∅, 1, BDNF↓, 4, BDNF↑, 216, BDNF⇅, 1, BDNF↝, 1, BDNF∅, 8, BrainVol↑, 3, BrainVol↝, 1, BrainVol∅, 3, ChAT↑, 22, ChE↓, 1, CHRM1↑, 1, DA↑, 1, DHCR7↑, 1, EndoR↑, 1, GABA↓, 4, GABA↑, 15, GABA↝, 1, GAD1/GAD67↑, 1, GDNF↑, 1, MAOA↓, 17, MAOA↑, 1, MAOA↝, 1, MAOB↓, 8, monoA↓, 1, monoA↑, 3, NGF↑, 15, NMDAR↑, 1, p‑NMDAR↑, 1, NTF3/NT-3↑, 1, PSD95?, 1, PSD95↑, 16, RELN↑, 1, SNAP25↑, 2, SYN1↑, 1, SYN3↓, 1, SYP↑, 2, SYT1↑, 1, TPH1↓, 1, TrkB↓, 2, TrkB↑, 25, TrkB↝, 1, β-Endo↑, 2,

Protein Aggregation(tgid=19) ⓘ

AEP↓, 1, AGEs↓, 16, APOE4↓, 1, APP↓, 27, APP∅, 2, cl‑APP↓, 1, cl‑APP↑, 1, Aβ?, 1, Aβ↓, 334, Aβ↑, 3, Aβ∅, 6, Aβ42↓, 11, BACE/β-secretase↓, 78, BACE/β-secretase↑, 3, BACE/β-secretase↝, 1, IDE↑, 3, NEP↑, 1, PSEN1/PS1↓, 2, PSEN1/PS1↑, 1, PSEN2/PS-2↓, 1, QPCT/QC↓, 1, tau?, 1, tau↓, 63, p‑tau↓, 94, XO↓, 6, XO↝, 1, β-Amyloid↓, 5,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 1, ACE/ACE1↓, 6, ACE2↓, 1, AHR↓, 1, AhR↑, 4, AKR1C3/17β-HSD5/PGF Synthase↑, 1, ARNT↑, 1, BNP↓, 1, cortisol↓, 2, cortisol↑, 1, CYP19↓, 2, DHT↓, 1, DHT↑, 1, END↑, 2, ENL↑, 1, ER(estro)↓, 1, ER(estro)↑, 2, ERβ/ESR2↑, 1, FGF21↑, 4, GLP-1R↑, 1, GPER↑, 1, GR↓, 1, GR↑, 5, GR↝, 1, Leptin↓, 1, PPARα↑, 14, PPARα↝, 1, PPARγ↓, 8, PPARγ↑, 30, p‑PPARγ↓, 1, PR↝, 1, RAAS↓, 1, SHBG↓, 1, testos↓, 1, testos↑, 5, testos?, 1, TSHR↓, 1, VDR↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1, AKR1B1/ALR2↑, 1, AKR1B10↝, 1, BioAv?, 4, BioAv↓, 205, BioAv↑, 343, BioAv⇅, 4, BioAv↝, 154, BioAv∅, 2, BioEnh↑, 36, BioEnh↝, 1, CES2↓, 1, ChemoSen↑, 4, CompStab↓, 2, CompStab↑, 2, CYP1A1↓, 3, CYP1A1↑, 1, CYP1A2↑, 1, CYP1B1↓, 1, CYP2A3/CYP2A6↝, 1, CYP2C19↓, 1, CYP2C6↓, 2, CYP2C6↑, 1, CYP2C8↓, 1, CYP2C9↓, 1, CYP2D1↑, 1, CYP2D6↓, 2, CYP2E1↓, 8, CYP3A2↓, 2, CYP3A2↑, 1, CYP3A4↓, 6, CYP3A4↑, 1, DDS↑, 5, Dose?, 19, Dose↓, 15, Dose↑, 38, Dose⇅, 4, Dose↝, 456, Dose∅, 10, eff?, 2, eff↓, 37, eff↑, 263, eff↝, 35, eff∅, 2, GSTA1↓, 2, GSTA1↑, 13, GSTP1/GSTπ↓, 1, Half-Life?, 2, Half-Life↓, 37, Half-Life↑, 27, Half-Life⇅, 1, Half-Life↝, 82, Half-Life∅, 6, MRP↓, 1, MRP1/ABCC1↓, 1, P-gp/ABCB1↓, 12, P-gp/ABCB1↑, 2, P450↓, 7, P450↑, 2, P450↝, 1, RadioS↑, 1, selectivity↑, 11, selectivity⇅, 1, Synergy↑, 73, TET2↑, 1, UGT1A↓, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1, ALAT↓, 96, ALAT↑, 3, ALAT∅, 4, ALB↑, 4, ALB↝, 1, ALP↓, 22, ALP↑, 2, ALP∅, 1, anemia↓, 1, ascitic↓, 1, AST↓, 95, AST↑, 3, AST∅, 4, BG↓, 9, Bil↓, 5, Bil↑, 2, BloodF↓, 1, BloodF↑, 21, BMD↑, 31, BP?, 1, BP↓, 69, BP↝, 1, BP∅, 3, BUN?, 1, BUN↓, 13, BUN↑, 1, Calcium↑, 2, Calcium↝, 2, CCr / CrCl↓, 1, CCr / CrCl∅, 1, CEA↓, 2, colonLen↑, 1, creat↓, 27, creat↑, 2, CRP↓, 29, EGFR↓, 3, Ferritin↓, 1, Ferritin↑, 2, FEV1↑, 2, HbA1c↓, 1, Hcy/homoC↓, 24, Hcy/homoC↝, 2, HemoG↑, 2, HER2/EBBR2↓, 1, HRV↑, 1, hs-CRP↓, 3, IL6?, 3, IL6↓, 258, IL6↑, 11, IRes↓, 3, IRes↑, 2, IRes↝, 1, LDH↓, 42, LDH↑, 3, LDH∅, 1, Mag↑, 2, NLR↓, 2, NOS2↓, 8, NSE↑, 1, OCN↑, 1, OCN∅, 1, PEF↑, 1, PSA↓, 2, PSA∅, 1, PV↓, 4, RAGE↓, 8, RBC↑, 2, rHR↓, 1, SpO2↑, 1, TG/TAG↓, 6, TMAO↓, 4, TMAO↑, 7, TMAO⇅, 1, TMAO∅, 2, TP53↑, 1, UFR↑, 3, UR↓, 2, Urea↓, 5, VitD↑, 6,

Functional Outcomes(tgid=23) ⓘ

Airway↓, 3, AirwayM↓, 4, Analgesic↑, 4, Anger↓, 1, AntiAge↑, 50, AntiAge⇅, 1, antiAll?, 1, antiAll↑, 77, antiAll∅, 1, AntiArt↑, 23, AntiCan?, 1, AntiCan↓, 4, AntiCan↑, 91, antiCG↑, 1, antiCG↝, 1, antiD↓, 1, AntiDiabetic↓, 4, AntiDiabetic↑, 113, antiM↑, 1, AntiMyl↑, 1, antiNeop↑, 1, antiPs↑, 5, antiPy↑, 1, AntiTum↓, 2, AntiTum↑, 31, ANXi↓, 4, Appetite↓, 1, BDI↓, 1, BOLD↑, 2, Bone Healing↑, 1, BowelM↑, 1, cachexia↓, 1, cachexia↑, 1, cardioP?, 2, cardioP↓, 4, cardioP↑, 260, cardioP⇅, 1, cardioP∅, 1, CardioT↓, 4, chemoP↑, 41, chemoPv↑, 32, ChemoSideEff↓, 1, cognitive?, 3, cognitive↓, 16, cognitive↑, 592, cognitive↝, 9, cognitive?, 1, cognitive∅, 27, cough?, 1, CryoP↑, 2, cytoP↑, 2, DCR∅, 1, diuretic↑, 10, fatigue↓, 6, GFR↓, 1, GFR↑, 1, GFR∅, 1, Hear↑, 1, hepatoP↓, 10, hepatoP↑, 245, IPSS↓, 1, Learn?, 2, Learn↑, 27, memory?, 4, memory↓, 4, memory↑, 411, memory∅, 6, Mood↑, 49, Mood⇅, 1, Mood↝, 1, motorD↓, 3, motorD↑, 67, Mucositis↓, 3, MusCon↓, 2, Nausea↓, 1, neuroP?, 4, neuroP↓, 5, neuroP↑, 709, neuroP↝, 1, NMSS↓, 1, NP/CIPN↓, 4, Obesity↓, 52, ORR∅, 1, OS↓, 1, OS↑, 44, Pain↓, 42, PDE4↓, 2, PFS∅, 1, QoL?, 1, QoL↑, 24, QoL∅, 1, radioP↑, 48, RenoP↓, 2, RenoP↑, 92, RenoP↝, 2, Risk↓, 75, Risk↑, 14, Risk↝, 2, Risk∅, 3, RT↓, 2, Sleep↑, 25, Sleep∅, 1, SoreThr?, 1, Strength↓, 1, Strength↑, 15, Stress↓, 10, Stroke↓, 47, Stroke↑, 1, Stroke↝, 1, Tinn↓, 4, toxicity?, 6, toxicity↓, 321, toxicity↑, 37, toxicity⇅, 2, toxicity↝, 75, toxicity∅, 70, UPDRS↓, 1, UPDRSIII∅, 1, Vomit↓, 1, Weight↓, 17, Weight↑, 4, Weight↝, 3, Weight∅, 4, Wound Healing↓, 2, Wound Healing↑, 40,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1, AntiBio↑, 61, AntiFungal↓, 2, AntiFungal↑, 32, AntiP↓, 1, AntiP↑, 15, AntiViral↑, 44, Bacteria?, 1, Bacteria↓, 137, Bacteria↑, 1, Dectin1↑, 1, Diar↓, 9, Dysb↓, 2, GutMicro↓, 1, GutMicro↑, 124, GutMicro↝, 9, GutMicro∅, 2, Inf↓, 4, insect↑, 1, Sepsis↓, 28,

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1, CA↑, 1, Catechins↑, 1, FA↑, 1, Fibre↑, 1, Flav↑, 1, GA↑, 1, Ingr?, 2, Ingr↑, 3, Ingr↝, 17, LT↑, 1, Myr↑, 1, Phen↑, 2, Poly↑, 1, QC↑, 2,
Total Targets: 1608

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Cancer Database Query Results

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

Ingredients & Constituents(tgid=25) ⓘ

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

Ingredients & Constituents(tgid=25) ⓘ

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